ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.75205303
2	viral transcription (GO:0019083)	6.28875508
3	translational termination (GO:0006415)	6.02328976
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.94628993
5	ATP synthesis coupled proton transport (GO:0015986)	5.94628993
6	DNA deamination (GO:0045006)	5.76687589
7	ribosomal small subunit biogenesis (GO:0042274)	5.67252529
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.60606033
9	translational elongation (GO:0006414)	5.29848098
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.29242793
11	cotranslational protein targeting to membrane (GO:0006613)	5.21392919
12	protein targeting to ER (GO:0045047)	5.18956208
13	maturation of SSU-rRNA (GO:0030490)	5.17672256
14	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.97517011
15	protein localization to endoplasmic reticulum (GO:0070972)	4.89501520
16	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.77627577
17	viral life cycle (GO:0019058)	4.61103102
18	cellular protein complex disassembly (GO:0043624)	4.49584357
19	behavioral response to nicotine (GO:0035095)	4.47345249
20	respiratory electron transport chain (GO:0022904)	4.34309229
21	electron transport chain (GO:0022900)	4.32802518
22	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.24364223
23	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.21572496
24	chaperone-mediated protein transport (GO:0072321)	4.17339937
25	protein complex biogenesis (GO:0070271)	4.16181135
26	protein neddylation (GO:0045116)	4.06596627
27	translational initiation (GO:0006413)	4.04957420
28	NADH dehydrogenase complex assembly (GO:0010257)	3.97162843
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.97162843
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.97162843
31	cytidine metabolic process (GO:0046087)	3.96805850
32	cytidine catabolic process (GO:0006216)	3.96805850
33	cytidine deamination (GO:0009972)	3.96805850
34	ribosomal large subunit biogenesis (GO:0042273)	3.95960130
35	translation (GO:0006412)	3.79205595
36	mitochondrial respiratory chain complex assembly (GO:0033108)	3.76066251
37	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.75931567
38	protein complex disassembly (GO:0043241)	3.68385114
39	ATP biosynthetic process (GO:0006754)	3.54777847
40	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.53081204
41	macromolecular complex disassembly (GO:0032984)	3.52242997
42	water-soluble vitamin biosynthetic process (GO:0042364)	3.51917066
43	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.48995484
44	GTP biosynthetic process (GO:0006183)	3.47708503
45	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.47316514
46	protein targeting to membrane (GO:0006612)	3.44456315
47	cellular component biogenesis (GO:0044085)	3.41686762
48	respiratory chain complex IV assembly (GO:0008535)	3.40025469
49	ribonucleoprotein complex biogenesis (GO:0022613)	3.32001089
50	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.29586910
51	hydrogen ion transmembrane transport (GO:1902600)	3.26762367
52	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.19675331
53	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.17248513
54	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.17046289
55	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.12667230
56	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.12667230
57	protein-cofactor linkage (GO:0018065)	3.08208380
58	cytochrome complex assembly (GO:0017004)	3.07933787
59	proton transport (GO:0015992)	3.06753572
60	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.06021153
61	termination of RNA polymerase III transcription (GO:0006386)	3.06021153
62	preassembly of GPI anchor in ER membrane (GO:0016254)	3.02081272
63	hydrogen transport (GO:0006818)	3.01798408
64	mRNA catabolic process (GO:0006402)	2.98686928
65	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.97911718
66	UTP biosynthetic process (GO:0006228)	2.82739892
67	kynurenine metabolic process (GO:0070189)	2.80668133
68	GPI anchor metabolic process (GO:0006505)	2.78201951
69	ubiquinone biosynthetic process (GO:0006744)	2.75296338
70	sequestering of actin monomers (GO:0042989)	2.73315621
71	platelet dense granule organization (GO:0060155)	2.72779125
72	pyrimidine nucleotide catabolic process (GO:0006244)	2.71100066
73	mannosylation (GO:0097502)	2.70033035
74	GPI anchor biosynthetic process (GO:0006506)	2.69460018
75	RNA catabolic process (GO:0006401)	2.69184286
76	pseudouridine synthesis (GO:0001522)	2.68227155
77	rRNA processing (GO:0006364)	2.66225097
78	metallo-sulfur cluster assembly (GO:0031163)	2.64562836
79	iron-sulfur cluster assembly (GO:0016226)	2.64562836
80	indole-containing compound catabolic process (GO:0042436)	2.63677387
81	indolalkylamine catabolic process (GO:0046218)	2.63677387
82	tryptophan catabolic process (GO:0006569)	2.63677387
83	rRNA metabolic process (GO:0016072)	2.63304856
84	base-excision repair, AP site formation (GO:0006285)	2.63296303
85	UTP metabolic process (GO:0046051)	2.62002427
86	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.57782573
87	nucleoside triphosphate biosynthetic process (GO:0009142)	2.57240779
88	indolalkylamine metabolic process (GO:0006586)	2.51583989
89	regulation of cellular amino acid metabolic process (GO:0006521)	2.49509543
90	positive regulation of T cell apoptotic process (GO:0070234)	2.46797264
91	protein polyglutamylation (GO:0018095)	2.45354344
92	rRNA modification (GO:0000154)	2.44947744
93	protein targeting to mitochondrion (GO:0006626)	2.43212032
94	positive regulation of respiratory burst (GO:0060267)	2.41769554
95	regulation of isotype switching to IgG isotypes (GO:0048302)	2.41490746
96	piRNA metabolic process (GO:0034587)	2.40940474
97	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.40232227
98	establishment of protein localization to mitochondrion (GO:0072655)	2.39508909
99	tRNA processing (GO:0008033)	2.38672349
100	ubiquinone metabolic process (GO:0006743)	2.38533240

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.61753236
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.94077760
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.51333437
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.28088174
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.26560289
6	EZH2_22144423_ChIP-Seq_EOC_Human	3.10902169
7	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.95265255
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.90182552
9	VDR_22108803_ChIP-Seq_LS180_Human	2.85910062
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.75283947
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.58202591
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.49460135
13	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.47862632
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.31869271
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.20909511
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.93313462
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.90180179
18	FOXP3_21729870_ChIP-Seq_TREG_Human	1.79858547
19	MYC_18940864_ChIP-ChIP_HL60_Human	1.76050889
20	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.70086823
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.68322786
22	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.66591370
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66085304
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.65424229
25	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.63671052
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.62039652
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.59015647
28	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.54655704
29	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.49410042
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.47970796
31	IGF1R_20145208_ChIP-Seq_DFB_Human	1.47945737
32	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.45418334
33	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.43201412
34	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.39736756
35	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.38632053
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38130128
37	TAF2_19829295_ChIP-Seq_ESCs_Human	1.35196268
38	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.34797603
39	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.33159742
40	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.33128744
41	EWS_26573619_Chip-Seq_HEK293_Human	1.31973070
42	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.31232986
43	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30122132
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29981119
45	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.29503606
46	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.28146798
47	TTF2_22483619_ChIP-Seq_HELA_Human	1.27029166
48	AR_20517297_ChIP-Seq_VCAP_Human	1.26882925
49	NANOG_20526341_ChIP-Seq_ESCs_Human	1.26514222
50	NCOR_22424771_ChIP-Seq_293T_Human	1.24910083
51	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.23761312
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22054465
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22054465
54	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.20839705
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.19217304
56	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.17573226
57	ERA_21632823_ChIP-Seq_H3396_Human	1.16318604
58	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.15452397
59	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.14442148
60	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13089993
61	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.12293011
62	BCL6_27268052_Chip-Seq_Bcells_Human	1.10544064
63	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.10484178
64	GABP_19822575_ChIP-Seq_HepG2_Human	1.10397585
65	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.10281549
66	GATA3_26560356_Chip-Seq_TH2_Human	1.08894216
67	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.08853136
68	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.08789222
69	XRN2_22483619_ChIP-Seq_HELA_Human	1.08168674
70	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.07979690
71	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.07596768
72	MYC_19829295_ChIP-Seq_ESCs_Human	1.06674296
73	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.04174230
74	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02099759
75	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.01988982
76	FUS_26573619_Chip-Seq_HEK293_Human	1.01503199
77	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99347749
78	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99347749
79	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98858753
80	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.96635706
81	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.95968918
82	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.95562080
83	P53_21459846_ChIP-Seq_SAOS-2_Human	0.95031458
84	CTCF_20526341_ChIP-Seq_ESCs_Human	0.94786669
85	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.92481411
86	ER_23166858_ChIP-Seq_MCF-7_Human	0.92435463
87	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.92415704
88	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.92152247
89	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.91007585
90	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.90930461
91	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.90858756
92	CBP_20019798_ChIP-Seq_JUKART_Human	0.90858756
93	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.89791874
94	P300_27268052_Chip-Seq_Bcells_Human	0.89702629
95	REST_21632747_ChIP-Seq_MESCs_Mouse	0.89392237
96	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.89360053
97	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.89331891
98	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.88349864
99	ERG_20517297_ChIP-Seq_VCAP_Human	0.88045887
100	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.88041903

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.98786902
2	MP0006292_abnormal_olfactory_placode	3.35614513
3	MP0005671_abnormal_response_to	2.96584896
4	MP0008877_abnormal_DNA_methylation	2.42197793
5	MP0002163_abnormal_gland_morphology	2.34563190
6	MP0003787_abnormal_imprinting	2.17637638
7	MP0002102_abnormal_ear_morphology	2.15931343
8	MP0002837_dystrophic_cardiac_calcinosis	2.07477781
9	MP0002653_abnormal_ependyma_morphology	2.04474524
10	MP0001835_abnormal_antigen_presentation	2.02231896
11	MP0004142_abnormal_muscle_tone	1.98855303
12	MP0008872_abnormal_physiological_respon	1.98212262
13	MP0004145_abnormal_muscle_electrophysio	1.96319743
14	MP0005646_abnormal_pituitary_gland	1.95636773
15	MP0003646_muscle_fatigue	1.90302031
16	MP0001986_abnormal_taste_sensitivity	1.89555592
17	MP0005645_abnormal_hypothalamus_physiol	1.83306565
18	MP0006276_abnormal_autonomic_nervous	1.76573847
19	MP0008875_abnormal_xenobiotic_pharmacok	1.75782438
20	MP0001968_abnormal_touch/_nociception	1.75321367
21	MP0004147_increased_porphyrin_level	1.75196152
22	MP0000372_irregular_coat_pigmentation	1.73937686
23	MP0002736_abnormal_nociception_after	1.69360663
24	MP0005551_abnormal_eye_electrophysiolog	1.65339055
25	MP0006072_abnormal_retinal_apoptosis	1.58462909
26	MP0002876_abnormal_thyroid_physiology	1.55800959
27	MP0002638_abnormal_pupillary_reflex	1.54085579
28	MP0008789_abnormal_olfactory_epithelium	1.47454587
29	MP0003878_abnormal_ear_physiology	1.46645788
30	MP0005377_hearing/vestibular/ear_phenot	1.46645788
31	MP0004885_abnormal_endolymph	1.45696133
32	MP0001905_abnormal_dopamine_level	1.45143815
33	MP0005379_endocrine/exocrine_gland_phen	1.43853968
34	MP0003880_abnormal_central_pattern	1.37806699
35	MP0001873_stomach_inflammation	1.36502345
36	MP0005389_reproductive_system_phenotype	1.36192162
37	MP0001800_abnormal_humoral_immune	1.35709259
38	MP0002277_abnormal_respiratory_mucosa	1.34205842
39	MP0002234_abnormal_pharynx_morphology	1.33725537
40	MP0001919_abnormal_reproductive_system	1.32597057
41	MP0009333_abnormal_splenocyte_physiolog	1.32592654
42	MP0001529_abnormal_vocalization	1.31573353
43	MP0002272_abnormal_nervous_system	1.31560386
44	MP0003011_delayed_dark_adaptation	1.30877837
45	MP0002148_abnormal_hypersensitivity_rea	1.29263823
46	MP0009785_altered_susceptibility_to	1.27789968
47	MP0005423_abnormal_somatic_nervous	1.23959559
48	MP0002160_abnormal_reproductive_system	1.23345671
49	MP0005084_abnormal_gallbladder_morpholo	1.22307285
50	MP0008995_early_reproductive_senescence	1.20617612
51	MP0002095_abnormal_skin_pigmentation	1.19479100
52	MP0000685_abnormal_immune_system	1.16362435
53	MP0003186_abnormal_redox_activity	1.16086798
54	MP0002138_abnormal_hepatobiliary_system	1.14372682
55	MP0003786_premature_aging	1.13415318
56	MP0009745_abnormal_behavioral_response	1.12212920
57	MP0004742_abnormal_vestibular_system	1.11949726
58	MP0003806_abnormal_nucleotide_metabolis	1.10861144
59	MP0001485_abnormal_pinna_reflex	1.09714327
60	MP0009764_decreased_sensitivity_to	1.08895276
61	MP0006036_abnormal_mitochondrial_physio	1.08061583
62	MP0002723_abnormal_immune_serum	1.05071902
63	MP0001970_abnormal_pain_threshold	1.03197190
64	MP0005075_abnormal_melanosome_morpholog	1.03162421
65	MP0002733_abnormal_thermal_nociception	1.01147281
66	MP0005000_abnormal_immune_tolerance	0.98335865
67	MP0009046_muscle_twitch	0.98226670
68	MP0001440_abnormal_grooming_behavior	0.96357751
69	MP0001293_anophthalmia	0.95904402
70	MP0005387_immune_system_phenotype	0.94624676
71	MP0001790_abnormal_immune_system	0.94624676
72	MP0008058_abnormal_DNA_repair	0.94292547
73	MP0003866_abnormal_defecation	0.93713887
74	MP0005253_abnormal_eye_physiology	0.91751282
75	MP0005394_taste/olfaction_phenotype	0.91445034
76	MP0005499_abnormal_olfactory_system	0.91445034
77	MP0002420_abnormal_adaptive_immunity	0.87860264
78	MP0000631_abnormal_neuroendocrine_gland	0.87832626
79	MP0001764_abnormal_homeostasis	0.85967989
80	MP0001819_abnormal_immune_cell	0.85737097
81	MP0002938_white_spotting	0.84164409
82	MP0008775_abnormal_heart_ventricle	0.82794538
83	MP0005195_abnormal_posterior_eye	0.82748553
84	MP0002452_abnormal_antigen_presenting	0.82429702
85	MP0002822_catalepsy	0.81318508
86	MP0000049_abnormal_middle_ear	0.80525300
87	MP0003121_genomic_imprinting	0.78662688
88	MP0001663_abnormal_digestive_system	0.77867290
89	MP0001984_abnormal_olfaction	0.75962874
90	MP0005174_abnormal_tail_pigmentation	0.75501238
91	MP0005636_abnormal_mineral_homeostasis	0.75476577
92	MP0005410_abnormal_fertilization	0.75179006
93	MP0002735_abnormal_chemical_nociception	0.74736186
94	MP0002557_abnormal_social/conspecific_i	0.74606853
95	MP0000230_abnormal_systemic_arterial	0.74298148
96	MP0006035_abnormal_mitochondrial_morpho	0.74091692
97	MP0001486_abnormal_startle_reflex	0.73817110
98	MP0002572_abnormal_emotion/affect_behav	0.72450726
99	MP0005025_abnormal_response_to	0.72088642
100	MP0002184_abnormal_innervation	0.71832098

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.08325722
2	Mitochondrial inheritance (HP:0001427)	4.60499015
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.58421939
4	Acute encephalopathy (HP:0006846)	4.30811777
5	Progressive macrocephaly (HP:0004481)	4.20751937
6	Increased CSF lactate (HP:0002490)	4.10244563
7	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.95418618
8	Reticulocytopenia (HP:0001896)	3.89553610
9	Abnormality of cells of the erythroid lineage (HP:0012130)	3.79712570
10	Hepatocellular necrosis (HP:0001404)	3.77135457
11	Increased hepatocellular lipid droplets (HP:0006565)	3.66387312
12	Pancreatic cysts (HP:0001737)	3.49640831
13	Lipid accumulation in hepatocytes (HP:0006561)	3.42664921
14	Hepatic necrosis (HP:0002605)	3.33214397
15	Abnormal number of erythroid precursors (HP:0012131)	3.32721582
16	Renal Fanconi syndrome (HP:0001994)	3.32400713
17	Congenital stationary night blindness (HP:0007642)	3.29381572
18	Cerebral edema (HP:0002181)	3.27060907
19	Pancreatic fibrosis (HP:0100732)	3.26683130
20	Abnormal rod and cone electroretinograms (HP:0008323)	3.25714205
21	Molar tooth sign on MRI (HP:0002419)	3.19767071
22	Abnormality of midbrain morphology (HP:0002418)	3.19767071
23	3-Methylglutaconic aciduria (HP:0003535)	3.12875501
24	Pendular nystagmus (HP:0012043)	3.08809547
25	Increased intramyocellular lipid droplets (HP:0012240)	3.08361378
26	Optic disc pallor (HP:0000543)	2.96860734
27	Macrocytic anemia (HP:0001972)	2.91913086
28	True hermaphroditism (HP:0010459)	2.91659578
29	IgG deficiency (HP:0004315)	2.86220463
30	Elevated erythrocyte sedimentation rate (HP:0003565)	2.86218977
31	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.75742865
32	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.75742865
33	Decreased central vision (HP:0007663)	2.72793410
34	Increased serum lactate (HP:0002151)	2.67399039
35	Increased muscle lipid content (HP:0009058)	2.61423096
36	Abolished electroretinogram (ERG) (HP:0000550)	2.56134260
37	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.55278696
38	Absent/shortened dynein arms (HP:0200106)	2.55278696
39	Lactic acidosis (HP:0003128)	2.54649426
40	Type II lissencephaly (HP:0007260)	2.51002013
41	Exertional dyspnea (HP:0002875)	2.50828656
42	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.46753030
43	Pallor (HP:0000980)	2.44880326
44	Absent thumb (HP:0009777)	2.41036956
45	Stomatitis (HP:0010280)	2.38835210
46	Attenuation of retinal blood vessels (HP:0007843)	2.38403202
47	Nephronophthisis (HP:0000090)	2.36741617
48	Keratoconus (HP:0000563)	2.35839595
49	Increased corneal curvature (HP:0100692)	2.35839595
50	Abnormality of renal resorption (HP:0011038)	2.35289263
51	Sclerocornea (HP:0000647)	2.31559331
52	Respiratory failure (HP:0002878)	2.25445419
53	Increased IgM level (HP:0003496)	2.24561131
54	Medial flaring of the eyebrow (HP:0010747)	2.24518976
55	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.24417106
56	Leukodystrophy (HP:0002415)	2.18517502
57	Lethargy (HP:0001254)	2.18061375
58	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.15411915
59	Congenital, generalized hypertrichosis (HP:0004540)	2.13525182
60	Aplastic anemia (HP:0001915)	2.13485503
61	Chronic hepatic failure (HP:0100626)	2.12963688
62	Cystic liver disease (HP:0006706)	2.12895655
63	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.10241019
64	Abnormality of alanine metabolism (HP:0010916)	2.10241019
65	Hyperalaninemia (HP:0003348)	2.10241019
66	Abnormality of B cell number (HP:0010975)	2.09287234
67	Abnormality of urine glucose concentration (HP:0011016)	2.08461926
68	Glycosuria (HP:0003076)	2.08461926
69	Anencephaly (HP:0002323)	2.06047122
70	Exercise intolerance (HP:0003546)	2.06014188
71	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.01244310
72	Type 2 muscle fiber atrophy (HP:0003554)	1.98000270
73	Abnormal respiratory epithelium morphology (HP:0012253)	1.97424379
74	Abnormal respiratory motile cilium morphology (HP:0005938)	1.97424379
75	Abnormality of the renal medulla (HP:0100957)	1.95478768
76	Hyperphosphaturia (HP:0003109)	1.94029410
77	Abnormality of the renal cortex (HP:0011035)	1.93945993
78	Asplenia (HP:0001746)	1.92144651
79	Constricted visual fields (HP:0001133)	1.90285767
80	Stenosis of the external auditory canal (HP:0000402)	1.85774271
81	Hypoproteinemia (HP:0003075)	1.84230264
82	Polydipsia (HP:0001959)	1.83732220
83	Abnormal drinking behavior (HP:0030082)	1.83732220
84	Colon cancer (HP:0003003)	1.80871171
85	Hyperglycinemia (HP:0002154)	1.80799389
86	Respiratory difficulties (HP:0002880)	1.79677940
87	Abnormality of DNA repair (HP:0003254)	1.77439866
88	Abnormal ciliary motility (HP:0012262)	1.77063392
89	Severe combined immunodeficiency (HP:0004430)	1.75912957
90	Concave nail (HP:0001598)	1.73088262
91	Muscle fiber atrophy (HP:0100295)	1.71045788
92	Postaxial foot polydactyly (HP:0001830)	1.67604727
93	Septo-optic dysplasia (HP:0100842)	1.66289247
94	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.65996145
95	Abnormality of the prostate (HP:0008775)	1.65209854
96	Agitation (HP:0000713)	1.65109232
97	Aplasia/hypoplasia of the uterus (HP:0008684)	1.63441356
98	X-linked dominant inheritance (HP:0001423)	1.62871293
99	Male pseudohermaphroditism (HP:0000037)	1.61320206
100	Myokymia (HP:0002411)	1.60479726

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.42402309
2	TLK1	2.86965151
3	STK16	2.83961090
4	VRK2	2.83733099
5	WNK4	2.82967596
6	NUAK1	2.78574348
7	TAOK3	2.71760374
8	ADRBK2	2.67956694
9	ZAK	2.65451440
10	BCKDK	2.52142499
11	KDR	2.35436109
12	MAP4K2	2.32002093
13	GRK1	2.12062808
14	PASK	2.05923304
15	PINK1	1.92926025
16	MAP4K1	1.80006407
17	CDK19	1.74907420
18	TIE1	1.73638057
19	DYRK2	1.60161815
20	FRK	1.59769891
21	CAMKK2	1.50968167
22	BMPR1B	1.49192233
23	VRK1	1.45006235
24	STK39	1.42908878
25	WNK3	1.39186378
26	TEC	1.31434861
27	MAP3K12	1.31212379
28	ITK	1.27383149
29	TNIK	1.26169305
30	CAMKK1	1.24653625
31	PRKCQ	1.19765699
32	OXSR1	1.18027610
33	NME2	1.17556010
34	TESK2	1.16416439
35	IKBKB	1.08787701
36	SYK	0.95149065
37	GRK6	0.95115080
38	MAPK13	0.90910098
39	INSRR	0.90757641
40	MAP3K11	0.88198192
41	RPS6KA5	0.86513160
42	BTK	0.86090527
43	NME1	0.81884686
44	CDK8	0.79528964
45	KIT	0.79102281
46	LRRK2	0.78941800
47	PIK3CA	0.78209448
48	ADRBK1	0.76718908
49	LCK	0.75191784
50	MUSK	0.73926618
51	DAPK1	0.73131711
52	MAP2K7	0.71454732
53	MAP3K4	0.69389359
54	BMPR2	0.69290709
55	FES	0.69107950
56	PHKG1	0.69032509
57	PHKG2	0.69032509
58	PRKCG	0.68834634
59	MYLK	0.66598835
60	LIMK1	0.66311429
61	CSNK1G3	0.64417701
62	IKBKE	0.63403908
63	DAPK3	0.60611240
64	LYN	0.60011204
65	CSNK1G2	0.59737658
66	CAMK1	0.59361999
67	PLK4	0.57982946
68	PRKACA	0.54719812
69	CSNK2A2	0.51836124
70	GRK7	0.49845702
71	MAPKAPK3	0.49119768
72	OBSCN	0.48904548
73	PRKCA	0.46948369
74	ABL2	0.46666846
75	NTRK2	0.45675592
76	PIM2	0.45230362
77	DAPK2	0.44340693
78	CSNK2A1	0.43017599
79	PDK2	0.42783760
80	GRK5	0.42265086
81	TNK2	0.42219752
82	MAPKAPK5	0.41470451
83	WNK1	0.40608661
84	BUB1	0.40184969
85	AURKA	0.40083068
86	PRKCD	0.38816682
87	CSNK1A1	0.38622275
88	PRKCI	0.38525844
89	RIPK4	0.38305319
90	PIM1	0.38244794
91	CSNK1G1	0.37892467
92	RPS6KA6	0.37596871
93	CSF1R	0.37023865
94	AURKB	0.36835321
95	PAK3	0.35752416
96	IGF1R	0.34756089
97	PRKCE	0.34679637
98	ACVR1B	0.33572369
99	CSNK1A1L	0.33552686
100	PLK2	0.33276364

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.16229092
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.10346116
3	Parkinsons disease_Homo sapiens_hsa05012	3.43095311
4	Proteasome_Homo sapiens_hsa03050	3.12974171
5	Asthma_Homo sapiens_hsa05310	2.99421828
6	Allograft rejection_Homo sapiens_hsa05330	2.47131111
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.39763285
8	RNA polymerase_Homo sapiens_hsa03020	2.39075086
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.35965448
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.35334361
11	Alzheimers disease_Homo sapiens_hsa05010	2.26100533
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.25837696
13	Graft-versus-host disease_Homo sapiens_hsa05332	2.22410046
14	Huntingtons disease_Homo sapiens_hsa05016	2.20878208
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.12583291
16	Protein export_Homo sapiens_hsa03060	1.96473231
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.95855038
18	Type I diabetes mellitus_Homo sapiens_hsa04940	1.89839285
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.89700235
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.70848801
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.60491976
22	Homologous recombination_Homo sapiens_hsa03440	1.45548868
23	Phototransduction_Homo sapiens_hsa04744	1.39375712
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.37274283
25	Antigen processing and presentation_Homo sapiens_hsa04612	1.32902500
26	RNA degradation_Homo sapiens_hsa03018	1.32109509
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.26180273
28	One carbon pool by folate_Homo sapiens_hsa00670	1.22564976
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.16375253
30	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.13427598
31	Rheumatoid arthritis_Homo sapiens_hsa05323	1.13374420
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.13009380
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.11418713
34	Caffeine metabolism_Homo sapiens_hsa00232	1.11359995
35	Basal transcription factors_Homo sapiens_hsa03022	1.07105046
36	Sulfur relay system_Homo sapiens_hsa04122	0.99951274
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.96543330
38	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.93655501
39	Fanconi anemia pathway_Homo sapiens_hsa03460	0.92705966
40	Nucleotide excision repair_Homo sapiens_hsa03420	0.91404771
41	Purine metabolism_Homo sapiens_hsa00230	0.89270777
42	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.86129762
43	Peroxisome_Homo sapiens_hsa04146	0.83014963
44	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.80983118
45	Tryptophan metabolism_Homo sapiens_hsa00380	0.80770030
46	Nicotine addiction_Homo sapiens_hsa05033	0.78287507
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.76589428
48	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.76111918
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.75895020
50	DNA replication_Homo sapiens_hsa03030	0.72842285
51	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.71897008
52	Mismatch repair_Homo sapiens_hsa03430	0.71309554
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.70948032
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.70024898
55	Butanoate metabolism_Homo sapiens_hsa00650	0.69589949
56	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.68207681
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67690078
58	Base excision repair_Homo sapiens_hsa03410	0.67285475
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.67258510
60	Propanoate metabolism_Homo sapiens_hsa00640	0.65758057
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.65627909
62	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.65317406
63	Retinol metabolism_Homo sapiens_hsa00830	0.64648338
64	Olfactory transduction_Homo sapiens_hsa04740	0.64290022
65	Metabolic pathways_Homo sapiens_hsa01100	0.63113572
66	Viral myocarditis_Homo sapiens_hsa05416	0.61898675
67	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.60026553
68	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.57981805
69	Regulation of autophagy_Homo sapiens_hsa04140	0.57836964
70	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.57515801
71	Ether lipid metabolism_Homo sapiens_hsa00565	0.57378441
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56893704
73	Sulfur metabolism_Homo sapiens_hsa00920	0.55927364
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.55534195
75	Spliceosome_Homo sapiens_hsa03040	0.54330143
76	Collecting duct acid secretion_Homo sapiens_hsa04966	0.54067125
77	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.53071071
78	RNA transport_Homo sapiens_hsa03013	0.51137837
79	Morphine addiction_Homo sapiens_hsa05032	0.48895576
80	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.47959221
81	Selenocompound metabolism_Homo sapiens_hsa00450	0.46734385
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.45414467
83	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.44788566
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44218433
85	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.41518629
86	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.41224136
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.39204925
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38314910
89	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.38051844
90	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.36961658
91	Taste transduction_Homo sapiens_hsa04742	0.35381702
92	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.29082716
93	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.26255874
94	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.22420775
95	Serotonergic synapse_Homo sapiens_hsa04726	0.20719072
96	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.19989470
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.18837417
98	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.18261687
99	Tyrosine metabolism_Homo sapiens_hsa00350	0.15693478
100	Folate biosynthesis_Homo sapiens_hsa00790	0.15125574

RPS18P12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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