ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of female receptivity (GO:0045924)	7.59958874
2	female mating behavior (GO:0060180)	6.88025865
3	viral transcription (GO:0019083)	5.92657779
4	ribosomal small subunit assembly (GO:0000028)	5.78121272
5	translational termination (GO:0006415)	5.67411456
6	maturation of SSU-rRNA (GO:0030490)	5.50032130
7	ribosomal small subunit biogenesis (GO:0042274)	5.42101843
8	ATP synthesis coupled proton transport (GO:0015986)	5.10101158
9	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.10101158
10	translational elongation (GO:0006414)	4.90163114
11	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.84917043
12	protein targeting to ER (GO:0045047)	4.76268801
13	cotranslational protein targeting to membrane (GO:0006613)	4.75543853
14	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.65436747
15	DNA deamination (GO:0045006)	4.64103020
16	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.54561714
17	protein localization to endoplasmic reticulum (GO:0070972)	4.46740215
18	viral life cycle (GO:0019058)	4.28507127
19	cellular protein complex disassembly (GO:0043624)	4.19323292
20	chaperone-mediated protein transport (GO:0072321)	4.12068952
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.09886123
22	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.03306766
23	ribosomal large subunit biogenesis (GO:0042273)	3.95547901
24	electron transport chain (GO:0022900)	3.92484028
25	respiratory electron transport chain (GO:0022904)	3.90104384
26	negative regulation of T cell receptor signaling pathway (GO:0050860)	3.88825901
27	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.80936598
28	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.80936598
29	translational initiation (GO:0006413)	3.68176199
30	kynurenine metabolic process (GO:0070189)	3.67993899
31	water-soluble vitamin biosynthetic process (GO:0042364)	3.62511112
32	protein neddylation (GO:0045116)	3.58280316
33	GTP biosynthetic process (GO:0006183)	3.54325610
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.48352001
35	NADH dehydrogenase complex assembly (GO:0010257)	3.48352001
36	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.48352001
37	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.46201871
38	translation (GO:0006412)	3.45524407
39	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.44059796
40	protein complex disassembly (GO:0043241)	3.43502542
41	protein complex biogenesis (GO:0070271)	3.43404530
42	indole-containing compound catabolic process (GO:0042436)	3.43387150
43	indolalkylamine catabolic process (GO:0046218)	3.43387150
44	tryptophan catabolic process (GO:0006569)	3.43387150
45	indolalkylamine metabolic process (GO:0006586)	3.41720641
46	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.33331322
47	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.31495505
48	deoxyribonucleotide catabolic process (GO:0009264)	3.30048038
49	macromolecular complex disassembly (GO:0032984)	3.26327794
50	base-excision repair, AP site formation (GO:0006285)	3.22161418
51	tryptophan metabolic process (GO:0006568)	3.19438586
52	multicellular organismal reproductive behavior (GO:0033057)	3.13654364
53	mitochondrial respiratory chain complex assembly (GO:0033108)	3.12952131
54	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.12767909
55	S-adenosylmethionine metabolic process (GO:0046500)	3.12116367
56	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.11437317
57	deoxyribose phosphate catabolic process (GO:0046386)	3.11007854
58	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	3.09266873
59	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.08195404
60	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.08077696
61	relaxation of smooth muscle (GO:0044557)	3.05547452
62	UTP biosynthetic process (GO:0006228)	3.04794609
63	protein-chromophore linkage (GO:0018298)	3.04304301
64	cytidine metabolic process (GO:0046087)	3.04093534
65	cytidine catabolic process (GO:0006216)	3.04093534
66	cytidine deamination (GO:0009972)	3.04093534
67	ribonucleoprotein complex biogenesis (GO:0022613)	3.02820298
68	cellular component biogenesis (GO:0044085)	3.02636496
69	protein targeting to membrane (GO:0006612)	3.02436833
70	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.02351655
71	rRNA catabolic process (GO:0016075)	2.99910058
72	meiotic chromosome segregation (GO:0045132)	2.98460925
73	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.94933415
74	behavioral response to nicotine (GO:0035095)	2.94499287
75	ATP biosynthetic process (GO:0006754)	2.93627971
76	UTP metabolic process (GO:0046051)	2.90754095
77	tRNA processing (GO:0008033)	2.82095575
78	transmission of nerve impulse (GO:0019226)	2.82006890
79	mRNA catabolic process (GO:0006402)	2.81492052
80	cellular biogenic amine catabolic process (GO:0042402)	2.80542787
81	amine catabolic process (GO:0009310)	2.80542787
82	hydrogen ion transmembrane transport (GO:1902600)	2.79847604
83	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.77103073
84	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.74279808
85	proton transport (GO:0015992)	2.73250888
86	respiratory chain complex IV assembly (GO:0008535)	2.73195116
87	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.72277852
88	rRNA processing (GO:0006364)	2.72027320
89	L-methionine salvage (GO:0071267)	2.69821113
90	L-methionine biosynthetic process (GO:0071265)	2.69821113
91	amino acid salvage (GO:0043102)	2.69821113
92	regulation of T cell receptor signaling pathway (GO:0050856)	2.69266644
93	hydrogen transport (GO:0006818)	2.69048792
94	rRNA metabolic process (GO:0016072)	2.68681080
95	positive regulation of respiratory burst (GO:0060267)	2.68463323
96	rRNA modification (GO:0000154)	2.60882782
97	termination of RNA polymerase III transcription (GO:0006386)	2.60309835
98	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.60309835
99	regulation of isotype switching to IgG isotypes (GO:0048302)	2.59504173
100	CTP metabolic process (GO:0046036)	2.57604368

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.04189072
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.96496026
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.76865286
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.69679845
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.60541127
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.51788824
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.21643171
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.06590795
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.90135065
10	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.79214330
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.78668205
12	VDR_22108803_ChIP-Seq_LS180_Human	2.75565223
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.61931330
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.24198464
15	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.05435395
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.05410973
17	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.01226909
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.91060568
19	FOXP3_21729870_ChIP-Seq_TREG_Human	1.86291468
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.82419236
21	TP53_22573176_ChIP-Seq_HFKS_Human	1.68042630
22	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.67227234
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.60643426
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.60353549
25	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.58466303
26	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.56904236
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.55550803
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.54201950
29	TTF2_22483619_ChIP-Seq_HELA_Human	1.45647524
30	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.45580186
31	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.45164628
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44883112
33	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.43717563
34	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.43421173
35	TAF2_19829295_ChIP-Seq_ESCs_Human	1.39690593
36	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.38111219
37	AR_20517297_ChIP-Seq_VCAP_Human	1.37867260
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.31766466
39	P53_21459846_ChIP-Seq_SAOS-2_Human	1.31707893
40	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.31345358
41	NANOG_20526341_ChIP-Seq_ESCs_Human	1.31301585
42	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.30591175
43	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.30441434
44	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.29490930
45	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.28698756
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28435937
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28435937
48	ERA_21632823_ChIP-Seq_H3396_Human	1.27626897
49	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.25809106
50	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.25238986
51	FUS_26573619_Chip-Seq_HEK293_Human	1.24491232
52	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.24066973
53	STAT1_20625510_ChIP-Seq_HELA_Human	1.23559433
54	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.23421274
55	BCL6_27268052_Chip-Seq_Bcells_Human	1.23308000
56	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.22055615
57	NCOR_22424771_ChIP-Seq_293T_Human	1.21774733
58	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.21159100
59	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.20579387
60	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.20134409
61	HOXB7_26014856_ChIP-Seq_BT474_Human	1.19066106
62	EWS_26573619_Chip-Seq_HEK293_Human	1.18954833
63	E2F1_20622854_ChIP-Seq_HELA_Human	1.16772364
64	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.16339822
65	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.14361845
66	GATA3_26560356_Chip-Seq_TH2_Human	1.13675715
67	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.10187083
68	ERG_20517297_ChIP-Seq_VCAP_Human	1.09809730
69	XRN2_22483619_ChIP-Seq_HELA_Human	1.08894560
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08250262
71	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.07884184
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07002646
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07002646
74	GATA3_21867929_ChIP-Seq_TH1_Mouse	1.06170717
75	MYC_19829295_ChIP-Seq_ESCs_Human	1.04279527
76	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.01406944
77	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99673171
78	P300_27268052_Chip-Seq_Bcells_Human	0.99642108
79	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.99614635
80	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.99317431
81	CTCF_20526341_ChIP-Seq_ESCs_Human	0.99167270
82	GABP_19822575_ChIP-Seq_HepG2_Human	0.98545817
83	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.96147768
84	SA1_27219007_Chip-Seq_Bcells_Human	0.95358440
85	DCP1A_22483619_ChIP-Seq_HELA_Human	0.94761395
86	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94471069
87	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.94232131
88	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.93450174
89	SOX2_21211035_ChIP-Seq_LN229_Human	0.92718886
90	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.92670306
91	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.92266629
92	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.91606596
93	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.91322762
94	RBPJ_21746931_ChIP-Seq_IB4_Human	0.91088819
95	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.90959918
96	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.90177355
97	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.88306121
98	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.87757629
99	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.87740625
100	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.86617718

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	4.44287703
2	MP0009379_abnormal_foot_pigmentation	4.39661673
3	MP0002163_abnormal_gland_morphology	3.77840023
4	MP0000372_irregular_coat_pigmentation	3.18165635
5	MP0009780_abnormal_chondrocyte_physiolo	3.15979023
6	MP0006292_abnormal_olfactory_placode	2.91496569
7	MP0004885_abnormal_endolymph	2.70948107
8	MP0008875_abnormal_xenobiotic_pharmacok	2.69547019
9	MP0005360_urolithiasis	2.37362888
10	MP0008872_abnormal_physiological_respon	2.28826015
11	MP0003879_abnormal_hair_cell	2.26838782
12	MP0005379_endocrine/exocrine_gland_phen	2.25713104
13	MP0003806_abnormal_nucleotide_metabolis	2.24237962
14	MP0005646_abnormal_pituitary_gland	2.07511509
15	MP0002132_abnormal_respiratory_system	2.04720259
16	MP0005671_abnormal_response_to	1.93603139
17	MP0001835_abnormal_antigen_presentation	1.84604306
18	MP0006276_abnormal_autonomic_nervous	1.84588683
19	MP0002138_abnormal_hepatobiliary_system	1.81400446
20	MP0003646_muscle_fatigue	1.70308632
21	MP0001873_stomach_inflammation	1.68240530
22	MP0002102_abnormal_ear_morphology	1.64340416
23	MP0002653_abnormal_ependyma_morphology	1.60054014
24	MP0008789_abnormal_olfactory_epithelium	1.58631159
25	MP0006072_abnormal_retinal_apoptosis	1.56844337
26	MP0002876_abnormal_thyroid_physiology	1.56543150
27	MP0005551_abnormal_eye_electrophysiolog	1.56175126
28	MP0005645_abnormal_hypothalamus_physiol	1.54162599
29	MP0000685_abnormal_immune_system	1.53973790
30	MP0001485_abnormal_pinna_reflex	1.51453740
31	MP0001968_abnormal_touch/_nociception	1.50357303
32	MP0004147_increased_porphyrin_level	1.50274039
33	MP0004142_abnormal_muscle_tone	1.44619346
34	MP0005377_hearing/vestibular/ear_phenot	1.41642866
35	MP0003878_abnormal_ear_physiology	1.41642866
36	MP0003718_maternal_effect	1.41155648
37	MP0004381_abnormal_hair_follicle	1.38927875
38	MP0006036_abnormal_mitochondrial_physio	1.38339245
39	MP0003787_abnormal_imprinting	1.36933967
40	MP0002736_abnormal_nociception_after	1.36108269
41	MP0008775_abnormal_heart_ventricle	1.34544686
42	MP0002148_abnormal_hypersensitivity_rea	1.34447161
43	MP0004742_abnormal_vestibular_system	1.29625402
44	MP0008877_abnormal_DNA_methylation	1.29528190
45	MP0002277_abnormal_respiratory_mucosa	1.27872041
46	MP0005410_abnormal_fertilization	1.26922086
47	MP0003866_abnormal_defecation	1.22792356
48	MP0001348_abnormal_lacrimal_gland	1.21901290
49	MP0009333_abnormal_splenocyte_physiolog	1.20156169
50	MP0003638_abnormal_response/metabolism_	1.16509075
51	MP0010155_abnormal_intestine_physiology	1.16091987
52	MP0003938_abnormal_ear_development	1.15077001
53	MP0001986_abnormal_taste_sensitivity	1.14918858
54	MP0003186_abnormal_redox_activity	1.09819102
55	MP0009764_decreased_sensitivity_to	1.09548894
56	MP0001800_abnormal_humoral_immune	1.09318533
57	MP0001293_anophthalmia	1.03749112
58	MP0001501_abnormal_sleep_pattern	1.03235570
59	MP0000049_abnormal_middle_ear	1.03128273
60	MP0001905_abnormal_dopamine_level	1.02404372
61	MP0000230_abnormal_systemic_arterial	1.02190261
62	MP0005085_abnormal_gallbladder_physiolo	1.00074100
63	MP0005387_immune_system_phenotype	0.97928412
64	MP0001790_abnormal_immune_system	0.97928412
65	MP0005636_abnormal_mineral_homeostasis	0.97088429
66	MP0003011_delayed_dark_adaptation	0.96983656
67	MP0001663_abnormal_digestive_system	0.96897183
68	MP0002909_abnormal_adrenal_gland	0.91438805
69	MP0002938_white_spotting	0.91427685
70	MP0003195_calcinosis	0.90956344
71	MP0009785_altered_susceptibility_to	0.89277398
72	MP0003252_abnormal_bile_duct	0.89241902
73	MP0005389_reproductive_system_phenotype	0.86897141
74	MP0010030_abnormal_orbit_morphology	0.86336476
75	MP0000631_abnormal_neuroendocrine_gland	0.84071213
76	MP0002272_abnormal_nervous_system	0.82335094
77	MP0004019_abnormal_vitamin_homeostasis	0.80174146
78	MP0006035_abnormal_mitochondrial_morpho	0.79998685
79	MP0001919_abnormal_reproductive_system	0.79558748
80	MP0005084_abnormal_gallbladder_morpholo	0.78331357
81	MP0002160_abnormal_reproductive_system	0.77553173
82	MP0004145_abnormal_muscle_electrophysio	0.76367973
83	MP0005394_taste/olfaction_phenotype	0.76070776
84	MP0005499_abnormal_olfactory_system	0.76070776
85	MP0009745_abnormal_behavioral_response	0.76007158
86	MP0000647_abnormal_sebaceous_gland	0.75253356
87	MP0001529_abnormal_vocalization	0.75113979
88	MP0000681_abnormal_thyroid_gland	0.74028826
89	MP0001764_abnormal_homeostasis	0.73007127
90	MP0001963_abnormal_hearing_physiology	0.70456733
91	MP0005000_abnormal_immune_tolerance	0.69626089
92	MP0005332_abnormal_amino_acid	0.69440305
93	MP0005195_abnormal_posterior_eye	0.68305819
94	MP0000026_abnormal_inner_ear	0.67932500
95	MP0005253_abnormal_eye_physiology	0.67764260
96	MP0002452_abnormal_antigen_presenting	0.67607718
97	MP0002095_abnormal_skin_pigmentation	0.66448509
98	MP0009765_abnormal_xenobiotic_induced	0.65966475
99	MP0002234_abnormal_pharynx_morphology	0.65907525
100	MP0005187_abnormal_penis_morphology	0.65279504

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.84094658
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.31787027
3	Acute encephalopathy (HP:0006846)	4.23631219
4	Congenital stationary night blindness (HP:0007642)	4.22230823
5	Reticulocytopenia (HP:0001896)	4.20013557
6	Abnormality of cells of the erythroid lineage (HP:0012130)	4.10728024
7	Mitochondrial inheritance (HP:0001427)	4.03801841
8	Abnormal rod and cone electroretinograms (HP:0008323)	3.99588422
9	Progressive macrocephaly (HP:0004481)	3.94201860
10	Increased CSF lactate (HP:0002490)	3.69080187
11	Concave nail (HP:0001598)	3.56543957
12	Macrocytic anemia (HP:0001972)	3.47016532
13	Abnormal number of erythroid precursors (HP:0012131)	3.45972029
14	Hepatocellular necrosis (HP:0001404)	3.41257201
15	True hermaphroditism (HP:0010459)	3.34031240
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.16609594
17	Hepatic necrosis (HP:0002605)	3.13886008
18	Pancreatic cysts (HP:0001737)	3.11798824
19	Pancreatic fibrosis (HP:0100732)	3.09541650
20	Optic disc pallor (HP:0000543)	3.00929928
21	Cerebral edema (HP:0002181)	2.99163439
22	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.93213432
23	3-Methylglutaconic aciduria (HP:0003535)	2.90108397
24	11 pairs of ribs (HP:0000878)	2.83186365
25	Lipid accumulation in hepatocytes (HP:0006561)	2.77194754
26	Increased hepatocellular lipid droplets (HP:0006565)	2.74699384
27	Molar tooth sign on MRI (HP:0002419)	2.71282850
28	Abnormality of midbrain morphology (HP:0002418)	2.71282850
29	Conical tooth (HP:0000698)	2.70980094
30	Severe visual impairment (HP:0001141)	2.70427469
31	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.66897831
32	Attenuation of retinal blood vessels (HP:0007843)	2.65579490
33	Increased serum lactate (HP:0002151)	2.61068409
34	Type II lissencephaly (HP:0007260)	2.60915627
35	Asplenia (HP:0001746)	2.57453825
36	Pallor (HP:0000980)	2.54895133
37	Lactic acidosis (HP:0003128)	2.53729713
38	Respiratory difficulties (HP:0002880)	2.48251102
39	Abnormal biliary tract physiology (HP:0012439)	2.45285695
40	Bile duct proliferation (HP:0001408)	2.45285695
41	Increased intramyocellular lipid droplets (HP:0012240)	2.38709732
42	Decreased central vision (HP:0007663)	2.37323695
43	Elevated erythrocyte sedimentation rate (HP:0003565)	2.35807813
44	Abolished electroretinogram (ERG) (HP:0000550)	2.34070041
45	Respiratory failure (HP:0002878)	2.31354760
46	Lethargy (HP:0001254)	2.28316838
47	Hypoproteinemia (HP:0003075)	2.25332527
48	Abnormal hemoglobin (HP:0011902)	2.23051060
49	Renal Fanconi syndrome (HP:0001994)	2.21815195
50	Nephronophthisis (HP:0000090)	2.19830904
51	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.19745462
52	Leukodystrophy (HP:0002415)	2.18956488
53	Stomatitis (HP:0010280)	2.17923227
54	Tubular atrophy (HP:0000092)	2.17765347
55	IgG deficiency (HP:0004315)	2.17576572
56	Abnormality of the renal cortex (HP:0011035)	2.13951420
57	Increased muscle lipid content (HP:0009058)	2.12493651
58	Abnormality of the renal medulla (HP:0100957)	2.09641780
59	Abnormality of urine glucose concentration (HP:0011016)	2.07712895
60	Glycosuria (HP:0003076)	2.07712895
61	Cystic liver disease (HP:0006706)	2.07562538
62	Pigmentary retinal degeneration (HP:0001146)	2.03172684
63	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.02796787
64	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.02796787
65	X-linked dominant inheritance (HP:0001423)	2.01087345
66	Congenital, generalized hypertrichosis (HP:0004540)	1.99622013
67	Colon cancer (HP:0003003)	1.99496851
68	Keratoconjunctivitis (HP:0001096)	1.99145978
69	Abnormality of alanine metabolism (HP:0010916)	1.98593821
70	Hyperalaninemia (HP:0003348)	1.98593821
71	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.98593821
72	Sclerocornea (HP:0000647)	1.97569967
73	Pendular nystagmus (HP:0012043)	1.97502785
74	Absent thumb (HP:0009777)	1.96746784
75	Medial flaring of the eyebrow (HP:0010747)	1.92985913
76	Anencephaly (HP:0002323)	1.91769804
77	Exertional dyspnea (HP:0002875)	1.91574572
78	Chronic diarrhea (HP:0002028)	1.91002925
79	Cerebellar dysplasia (HP:0007033)	1.89606607
80	Keratoconjunctivitis sicca (HP:0001097)	1.87793486
81	Hyperthyroidism (HP:0000836)	1.86771304
82	Hyperglycinemia (HP:0002154)	1.81758518
83	Methylmalonic aciduria (HP:0012120)	1.81044274
84	Anhidrosis (HP:0000970)	1.79363075
85	Exercise intolerance (HP:0003546)	1.79286835
86	Abnormal drinking behavior (HP:0030082)	1.78738068
87	Polydipsia (HP:0001959)	1.78738068
88	Male pseudohermaphroditism (HP:0000037)	1.78604543
89	Abnormality of magnesium homeostasis (HP:0004921)	1.76198593
90	Increased IgM level (HP:0003496)	1.76015113
91	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.75211395
92	Depressed nasal ridge (HP:0000457)	1.73383866
93	Brittle hair (HP:0002299)	1.72250671
94	Abnormality of B cell number (HP:0010975)	1.71155758
95	Constricted visual fields (HP:0001133)	1.68974241
96	Bony spicule pigmentary retinopathy (HP:0007737)	1.68569259
97	CNS demyelination (HP:0007305)	1.66762325
98	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.65406589
99	Hypoplasia of the fovea (HP:0007750)	1.65406589
100	Pancytopenia (HP:0001876)	1.62559375

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	3.41907493
2	ADRBK2	3.22544935
3	FRK	3.08165373
4	VRK2	2.96771966
5	NUAK1	2.94498887
6	PINK1	2.86410005
7	TLK1	2.65622853
8	WNK4	2.60188948
9	TXK	2.43008010
10	GRK1	2.39757461
11	CDK19	2.38923757
12	MAP3K12	2.38528446
13	ZAK	2.08380666
14	KIT	2.01804941
15	STK16	2.00698608
16	BUB1	2.00550907
17	MST4	2.00143016
18	NME2	1.91235116
19	BCKDK	1.89362726
20	DYRK2	1.71447354
21	WNK3	1.52180901
22	OXSR1	1.41950504
23	DAPK2	1.33985173
24	STK39	1.31538911
25	LRRK2	1.31511244
26	MAP4K2	1.26576468
27	VRK1	1.26184774
28	CAMKK2	1.21014361
29	NME1	1.18026065
30	IKBKB	1.17872281
31	MYLK	1.08664193
32	TEC	1.07867227
33	MAP4K1	1.02980573
34	ADRBK1	1.02667838
35	DAPK3	1.02145839
36	ITK	1.01372825
37	KDR	0.96519442
38	TIE1	0.94965028
39	PRKCQ	0.93745625
40	BMPR1B	0.93200032
41	DAPK1	0.92263359
42	MAP3K11	0.89347840
43	TAF1	0.88521762
44	ACVR1B	0.87991028
45	PASK	0.86212402
46	PLK4	0.83282928
47	FES	0.82143906
48	ABL2	0.78587843
49	INSRR	0.78094083
50	PRKCG	0.76313942
51	CSNK2A2	0.74279417
52	PIK3CA	0.73990024
53	SYK	0.70734168
54	PDK2	0.68602125
55	CAMKK1	0.68290037
56	PLK2	0.67602076
57	CDC7	0.65776811
58	RPS6KA5	0.64860002
59	EIF2AK1	0.64353600
60	BTK	0.64272754
61	TSSK6	0.63192359
62	CSNK2A1	0.63163143
63	CSNK1G3	0.60322880
64	LYN	0.60200773
65	PHKG1	0.58359462
66	PHKG2	0.58359462
67	PRKCI	0.57535841
68	PAK3	0.57079620
69	AURKB	0.55519307
70	CSF1R	0.54181544
71	PRKACA	0.54116430
72	CSNK1A1	0.53721209
73	PRKCA	0.53668929
74	LCK	0.52785992
75	GRK6	0.52608039
76	JAK3	0.50179442
77	MAPKAPK3	0.49834448
78	PRKACG	0.47614450
79	ERBB2	0.47087604
80	CAMK1	0.46984007
81	MAP2K7	0.45912246
82	PLK1	0.45597054
83	CSNK1G2	0.45500287
84	OBSCN	0.44927624
85	MAP2K6	0.43963429
86	ILK	0.43641255
87	MAPKAPK5	0.43218401
88	IGF1R	0.42313610
89	PRKCD	0.41183498
90	EIF2AK2	0.40431527
91	CSNK1G1	0.40154093
92	EIF2AK3	0.40127325
93	IKBKE	0.38341768
94	NEK2	0.38281148
95	NEK1	0.37876270
96	BMPR2	0.37724656
97	PLK3	0.36644239
98	PRKCE	0.36392415
99	CHUK	0.36382244
100	CAMK2D	0.36106285

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.73350750
2	Asthma_Homo sapiens_hsa05310	3.61604399
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.51273899
4	Parkinsons disease_Homo sapiens_hsa05012	2.92564634
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.84197891
6	Allograft rejection_Homo sapiens_hsa05330	2.82871367
7	Proteasome_Homo sapiens_hsa03050	2.76130523
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.61313798
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.09972578
10	RNA polymerase_Homo sapiens_hsa03020	2.01650820
11	One carbon pool by folate_Homo sapiens_hsa00670	2.01476504
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.99217231
13	Alzheimers disease_Homo sapiens_hsa05010	1.98714443
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.97160607
15	Type I diabetes mellitus_Homo sapiens_hsa04940	1.95105076
16	Cardiac muscle contraction_Homo sapiens_hsa04260	1.92132946
17	Huntingtons disease_Homo sapiens_hsa05016	1.89867017
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.85993375
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.76929670
20	Caffeine metabolism_Homo sapiens_hsa00232	1.60816584
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.58798518
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.57809574
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.46938211
24	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.41775980
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.40430354
26	Phototransduction_Homo sapiens_hsa04744	1.37041484
27	Homologous recombination_Homo sapiens_hsa03440	1.33821385
28	RNA degradation_Homo sapiens_hsa03018	1.31474443
29	Primary immunodeficiency_Homo sapiens_hsa05340	1.26242910
30	Fat digestion and absorption_Homo sapiens_hsa04975	1.25768248
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.25702975
32	Pyrimidine metabolism_Homo sapiens_hsa00240	1.24564156
33	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.24296867
34	Protein export_Homo sapiens_hsa03060	1.22907706
35	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.14607842
36	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.04522443
37	Antigen processing and presentation_Homo sapiens_hsa04612	1.03982179
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03805371
39	Rheumatoid arthritis_Homo sapiens_hsa05323	0.99055112
40	Purine metabolism_Homo sapiens_hsa00230	0.93689469
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.88115309
42	Ether lipid metabolism_Homo sapiens_hsa00565	0.86858220
43	Retinol metabolism_Homo sapiens_hsa00830	0.86267680
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.86239989
45	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.85086960
46	Sulfur relay system_Homo sapiens_hsa04122	0.84993256
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.84236630
48	Basal transcription factors_Homo sapiens_hsa03022	0.82509984
49	Nitrogen metabolism_Homo sapiens_hsa00910	0.82468205
50	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.80471464
51	DNA replication_Homo sapiens_hsa03030	0.79489658
52	Base excision repair_Homo sapiens_hsa03410	0.79412204
53	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.79018917
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77521265
55	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.76915725
56	Fanconi anemia pathway_Homo sapiens_hsa03460	0.72832224
57	Butanoate metabolism_Homo sapiens_hsa00650	0.71451165
58	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.70411166
59	Metabolic pathways_Homo sapiens_hsa01100	0.70069363
60	Peroxisome_Homo sapiens_hsa04146	0.67930421
61	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67924375
62	Arginine and proline metabolism_Homo sapiens_hsa00330	0.67882271
63	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.66615797
64	Nucleotide excision repair_Homo sapiens_hsa03420	0.64090721
65	Nicotine addiction_Homo sapiens_hsa05033	0.64071727
66	Salivary secretion_Homo sapiens_hsa04970	0.63498336
67	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.62576135
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.60866008
69	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.60351257
70	Spliceosome_Homo sapiens_hsa03040	0.60147778
71	Mineral absorption_Homo sapiens_hsa04978	0.59794754
72	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.58793892
73	Viral myocarditis_Homo sapiens_hsa05416	0.58499972
74	Olfactory transduction_Homo sapiens_hsa04740	0.57202146
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56304064
76	Fatty acid degradation_Homo sapiens_hsa00071	0.55699335
77	Mismatch repair_Homo sapiens_hsa03430	0.55318828
78	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.53988285
79	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.50661787
80	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.49393395
81	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.48242779
82	RNA transport_Homo sapiens_hsa03013	0.47280608
83	Sulfur metabolism_Homo sapiens_hsa00920	0.45742915
84	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.45201528
85	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.45119349
86	Propanoate metabolism_Homo sapiens_hsa00640	0.44484998
87	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.44458226
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.40778937
89	Leishmaniasis_Homo sapiens_hsa05140	0.36352405
90	Tyrosine metabolism_Homo sapiens_hsa00350	0.35863513
91	Folate biosynthesis_Homo sapiens_hsa00790	0.34383674
92	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.32678923
93	Glutathione metabolism_Homo sapiens_hsa00480	0.30151653
94	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.28933037
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.28822138
96	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.28641207
97	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.27405896
98	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.23834801
99	Collecting duct acid secretion_Homo sapiens_hsa04966	0.23730093
100	Arginine biosynthesis_Homo sapiens_hsa00220	0.20788193

RPS18P13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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