RPS18P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.22706107
2cytidine deamination (GO:0009972)7.19726076
3cytidine metabolic process (GO:0046087)7.19726076
4cytidine catabolic process (GO:0006216)7.19726076
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.14095431
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.33440055
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.77225746
8ribosomal small subunit assembly (GO:0000028)4.67267625
9sequestering of actin monomers (GO:0042989)4.64181308
10Arp2/3 complex-mediated actin nucleation (GO:0034314)4.61132313
11positive thymic T cell selection (GO:0045059)4.58075139
12positive T cell selection (GO:0043368)4.54858589
13actin nucleation (GO:0045010)4.35600194
14regulation of activation of Janus kinase activity (GO:0010533)4.28381589
15T cell migration (GO:0072678)4.28030038
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.21466208
17negative regulation of T cell apoptotic process (GO:0070233)4.15512757
18negative T cell selection (GO:0043383)4.12393356
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.05100307
20positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.99342732
21regulation of B cell receptor signaling pathway (GO:0050855)3.97950180
22positive regulation of natural killer cell mediated immunity (GO:0002717)3.94630128
23positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.89888684
24ATP synthesis coupled proton transport (GO:0015986)3.85713051
25energy coupled proton transport, down electrochemical gradient (GO:0015985)3.85713051
26cytolysis (GO:0019835)3.84954416
27positive regulation of B cell differentiation (GO:0045579)3.81751322
28regulation of regulatory T cell differentiation (GO:0045589)3.78091952
29positive regulation of tolerance induction (GO:0002645)3.70754809
30positive regulation of calcium-mediated signaling (GO:0050850)3.68908868
31negative regulation of viral genome replication (GO:0045071)3.59976471
32regulation of leukocyte mediated cytotoxicity (GO:0001910)3.56332742
33regulation of natural killer cell mediated immunity (GO:0002715)3.55453451
34regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.55453451
35positive regulation of cell killing (GO:0031343)3.53667259
36positive regulation of T cell mediated cytotoxicity (GO:0001916)3.53197809
37regulation of T cell tolerance induction (GO:0002664)3.46824215
38mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.44307828
39pyrimidine nucleoside catabolic process (GO:0046135)3.42866238
40thymic T cell selection (GO:0045061)3.42719132
41negative regulation of stress fiber assembly (GO:0051497)3.35920102
42positive regulation of alpha-beta T cell proliferation (GO:0046641)3.34847643
43respiratory electron transport chain (GO:0022904)3.32738832
44negative thymic T cell selection (GO:0045060)3.32243900
45response to interferon-beta (GO:0035456)3.29920019
46positive regulation of uterine smooth muscle contraction (GO:0070474)3.28776355
47electron transport chain (GO:0022900)3.28527947
48positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.26518028
49regulation of cell killing (GO:0031341)3.25155165
50T cell receptor signaling pathway (GO:0050852)3.24929192
51regulation of T cell mediated cytotoxicity (GO:0001914)3.23231812
52negative regulation by host of viral transcription (GO:0043922)3.16552950
53response to pheromone (GO:0019236)3.16506184
54maturation of SSU-rRNA (GO:0030490)3.15327012
55iron-sulfur cluster assembly (GO:0016226)3.14161958
56metallo-sulfur cluster assembly (GO:0031163)3.14161958
57positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.11940262
58positive regulation of interleukin-17 production (GO:0032740)3.11903931
59positive regulation of gamma-delta T cell activation (GO:0046645)3.11897254
60cellular response to interleukin-15 (GO:0071350)3.10066133
61regulation of B cell differentiation (GO:0045577)3.08960803
62regulation of cellular amino acid metabolic process (GO:0006521)3.08137318
63T cell selection (GO:0045058)3.06177362
64positive regulation of defense response to virus by host (GO:0002230)3.05185623
65negative regulation of lymphocyte apoptotic process (GO:0070229)3.02738487
66regulation of alpha-beta T cell proliferation (GO:0046640)3.02151603
67positive regulation of interleukin-4 production (GO:0032753)2.99386450
68mast cell activation (GO:0045576)2.99357797
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.99145805
70regulation of isotype switching to IgG isotypes (GO:0048302)2.95499888
71negative regulation of oxidoreductase activity (GO:0051354)2.92272174
72positive regulation of interleukin-8 secretion (GO:2000484)2.91956987
73regulation of tolerance induction (GO:0002643)2.90948592
74regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.90825975
75regulation of chronic inflammatory response (GO:0002676)2.90411177
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.89212671
77regulation of T cell receptor signaling pathway (GO:0050856)2.83380188
78antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.82179620
79regulation of T cell apoptotic process (GO:0070232)2.80166796
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.77333839
81signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.77333839
82negative regulation of actin filament bundle assembly (GO:0032232)2.75276587
83signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.74959933
84signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.74959933
85signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.74959933
86T cell costimulation (GO:0031295)2.73133101
87RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.72517765
88tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.72517765
89natural killer cell activation (GO:0030101)2.71572153
90viral transcription (GO:0019083)2.71558884
91lymphocyte costimulation (GO:0031294)2.70166410
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.69100554
93regulation of T cell chemotaxis (GO:0010819)2.68921815
94positive regulation of T cell chemotaxis (GO:0010820)2.68921815
95regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.66612723
96eosinophil chemotaxis (GO:0048245)2.66324402
97translational elongation (GO:0006414)2.65911990
98antigen receptor-mediated signaling pathway (GO:0050851)2.65338062
99protein neddylation (GO:0045116)2.64718911
100negative regulation of mast cell activation (GO:0033004)2.62817757

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.08605638
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.98330406
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.87225238
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.76460489
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.56814335
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.40999215
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.23583232
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.22085063
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.05037852
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.02377112
11VDR_22108803_ChIP-Seq_LS180_Human2.69747050
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.51748484
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45953091
14EZH2_22144423_ChIP-Seq_EOC_Human2.23901805
15MYB_26560356_Chip-Seq_TH2_Human2.23828047
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.13295657
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.11992526
18VDR_23849224_ChIP-Seq_CD4+_Human2.02806025
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99577636
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.93041584
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.90795192
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89918365
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89725690
24ZNF274_21170338_ChIP-Seq_K562_Hela1.87745025
25RUNX_20019798_ChIP-Seq_JUKART_Human1.82209382
26IGF1R_20145208_ChIP-Seq_DFB_Human1.73805589
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68844206
28GATA3_27048872_Chip-Seq_THYMUS_Human1.68029512
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.67004824
30GATA3_26560356_Chip-Seq_TH2_Human1.57332034
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.54947086
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.54765381
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53397999
34RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.51904771
35HTT_18923047_ChIP-ChIP_STHdh_Human1.48344852
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41543851
37EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.40130850
38PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.38465240
39UTX_26944678_Chip-Seq_JUKART_Human1.35041734
40AR_20517297_ChIP-Seq_VCAP_Human1.33647765
41FOXP3_21729870_ChIP-Seq_TREG_Human1.31886563
42NANOG_20526341_ChIP-Seq_ESCs_Human1.31620640
43MYB_26560356_Chip-Seq_TH1_Human1.31582276
44TP53_22573176_ChIP-Seq_HFKS_Human1.29892563
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29231904
46TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.28525214
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.28217994
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.25056907
49BCL6_27268052_Chip-Seq_Bcells_Human1.23538747
50ELK1_19687146_ChIP-ChIP_HELA_Human1.23148747
51PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.22657052
52ER_23166858_ChIP-Seq_MCF-7_Human1.22376910
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21526648
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.19831035
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19493051
56MYC_18940864_ChIP-ChIP_HL60_Human1.19317266
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18518273
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14867264
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13845472
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13485246
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.13485246
62TAF2_19829295_ChIP-Seq_ESCs_Human1.12214704
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09330754
64NCOR_22424771_ChIP-Seq_293T_Human1.08186553
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.06980860
66STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06618196
67CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04633821
68ERG_20517297_ChIP-Seq_VCAP_Human1.04304547
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02158557
70MYC_19829295_ChIP-Seq_ESCs_Human1.01823028
71CTCF_20526341_ChIP-Seq_ESCs_Human0.98212473
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98045446
73FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97260247
74ERA_21632823_ChIP-Seq_H3396_Human0.95065295
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93265142
76EWS_26573619_Chip-Seq_HEK293_Human0.93071998
77EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92568220
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92197366
79CBP_20019798_ChIP-Seq_JUKART_Human0.92197366
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92087516
81PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91384064
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91134010
83P300_27268052_Chip-Seq_Bcells_Human0.90796234
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90642826
85GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90566079
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89978031
87MAF_26560356_Chip-Seq_TH2_Human0.89610172
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.89037971
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89031023
90NANOG_19829295_ChIP-Seq_ESCs_Human0.89020787
91SOX2_19829295_ChIP-Seq_ESCs_Human0.89020787
92P53_21459846_ChIP-Seq_SAOS-2_Human0.86980155
93MAF_26560356_Chip-Seq_TH1_Human0.86843053
94BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86521731
95GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.86475226
96GATA6_21074721_ChIP-Seq_CACO-2_Human0.86446716
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86069127
98YY1_22570637_ChIP-Seq_MALME-3M_Human0.86057555
99FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.85480319
100OCT4_20526341_ChIP-Seq_ESCs_Human0.84957002

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.06758813
2MP0009785_altered_susceptibility_to3.51417050
3MP0001835_abnormal_antigen_presentation3.29973892
4MP0003763_abnormal_thymus_physiology2.84642747
5MP0009333_abnormal_splenocyte_physiolog2.51717848
6MP0003646_muscle_fatigue2.45661298
7MP0005000_abnormal_immune_tolerance2.39738723
8MP0001873_stomach_inflammation2.27453584
9MP0005025_abnormal_response_to2.20545704
10MP0001800_abnormal_humoral_immune2.20252103
11MP0005645_abnormal_hypothalamus_physiol2.16327730
12MP0002420_abnormal_adaptive_immunity2.09012399
13MP0000372_irregular_coat_pigmentation2.07665051
14MP0002102_abnormal_ear_morphology2.07190902
15MP0002723_abnormal_immune_serum2.02305205
16MP0002166_altered_tumor_susceptibility2.01721529
17MP0002148_abnormal_hypersensitivity_rea2.01389514
18MP0001819_abnormal_immune_cell2.00695494
19MP0005387_immune_system_phenotype1.87722404
20MP0001790_abnormal_immune_system1.87722404
21MP0003878_abnormal_ear_physiology1.86772971
22MP0005377_hearing/vestibular/ear_phenot1.86772971
23MP0003866_abnormal_defecation1.79957718
24MP0004147_increased_porphyrin_level1.77875293
25MP0000685_abnormal_immune_system1.77550491
26MP0009379_abnormal_foot_pigmentation1.68332743
27MP0008872_abnormal_physiological_respon1.66931056
28MP0002452_abnormal_antigen_presenting1.65387918
29MP0002837_dystrophic_cardiac_calcinosis1.64766613
30MP0008875_abnormal_xenobiotic_pharmacok1.62485722
31MP0010155_abnormal_intestine_physiology1.60573742
32MP0000716_abnormal_immune_system1.58474462
33MP0002006_tumorigenesis1.57799248
34MP0005551_abnormal_eye_electrophysiolog1.50731402
35MP0002398_abnormal_bone_marrow1.50003036
36MP0002405_respiratory_system_inflammati1.46787611
37MP0002277_abnormal_respiratory_mucosa1.45977916
38MP0004145_abnormal_muscle_electrophysio1.45716177
39MP0005389_reproductive_system_phenotype1.43794688
40MP0005646_abnormal_pituitary_gland1.43738374
41MP0006072_abnormal_retinal_apoptosis1.41584629
42MP0001905_abnormal_dopamine_level1.38690506
43MP0001919_abnormal_reproductive_system1.36967888
44MP0001845_abnormal_inflammatory_respons1.34162740
45MP0006082_CNS_inflammation1.32328796
46MP0002933_joint_inflammation1.32003689
47MP0002736_abnormal_nociception_after1.26746530
48MP0002419_abnormal_innate_immunity1.24950828
49MP0000703_abnormal_thymus_morphology1.23968538
50MP0001968_abnormal_touch/_nociception1.23569215
51MP0002722_abnormal_immune_system1.23446079
52MP0005410_abnormal_fertilization1.23103797
53MP0002160_abnormal_reproductive_system1.21754353
54MP0003011_delayed_dark_adaptation1.19641233
55MP0003786_premature_aging1.18195638
56MP0000689_abnormal_spleen_morphology1.17732459
57MP0002429_abnormal_blood_cell1.16343706
58MP0008995_early_reproductive_senescence1.15922393
59MP0001485_abnormal_pinna_reflex1.15752187
60MP0008877_abnormal_DNA_methylation1.09746588
61MP0003195_calcinosis1.09459885
62MP0008469_abnormal_protein_level1.09371385
63MP0003448_altered_tumor_morphology1.09200738
64MP0002138_abnormal_hepatobiliary_system1.06467524
65MP0002638_abnormal_pupillary_reflex1.06351426
66MP0003436_decreased_susceptibility_to1.05604312
67MP0005253_abnormal_eye_physiology1.03167790
68MP0003137_abnormal_impulse_conducting1.00493518
69MP0003045_fibrosis0.97492220
70MP0003724_increased_susceptibility_to0.95784074
71MP0003880_abnormal_central_pattern0.94551128
72MP0006276_abnormal_autonomic_nervous0.93923537
73MP0002876_abnormal_thyroid_physiology0.93475026
74MP0005075_abnormal_melanosome_morpholog0.93332879
75MP0001986_abnormal_taste_sensitivity0.92410776
76MP0005636_abnormal_mineral_homeostasis0.92167440
77MP0004885_abnormal_endolymph0.91738744
78MP0002693_abnormal_pancreas_physiology0.89203615
79MP0005166_decreased_susceptibility_to0.88804649
80MP0001765_abnormal_ion_homeostasis0.88247900
81MP0005464_abnormal_platelet_physiology0.87423374
82MP0009764_decreased_sensitivity_to0.86927609
83MP0000465_gastrointestinal_hemorrhage0.86600056
84MP0009763_increased_sensitivity_to0.86099406
85MP0001764_abnormal_homeostasis0.84311464
86MP0002733_abnormal_thermal_nociception0.82514969
87MP0001853_heart_inflammation0.82487775
88MP0002163_abnormal_gland_morphology0.78192890
89MP0005360_urolithiasis0.77961152
90MP0009643_abnormal_urine_homeostasis0.77774835
91MP0002822_catalepsy0.75024152
92MP0001501_abnormal_sleep_pattern0.74597712
93MP0001970_abnormal_pain_threshold0.72537170
94MP0010386_abnormal_urinary_bladder0.72057965
95MP0006292_abnormal_olfactory_placode0.71814555
96MP0004142_abnormal_muscle_tone0.71579199
97MP0002019_abnormal_tumor_incidence0.69086796
98MP0001119_abnormal_female_reproductive0.68856247
99MP0005085_abnormal_gallbladder_physiolo0.67736390
100MP0004947_skin_inflammation0.67572423

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)6.19796279
2IgG deficiency (HP:0004315)4.71919561
3T lymphocytopenia (HP:0005403)4.59879507
4Abnormality of T cell number (HP:0011839)4.41974085
5Hypoproteinemia (HP:0003075)4.40531636
6Congenital stationary night blindness (HP:0007642)4.37332983
7Elevated erythrocyte sedimentation rate (HP:0003565)4.21353786
8Absent rod-and cone-mediated responses on ERG (HP:0007688)4.06088546
9Severe combined immunodeficiency (HP:0004430)3.75270275
10Mitochondrial inheritance (HP:0001427)3.65886705
11Autoimmune hemolytic anemia (HP:0001890)3.65777954
12Increased IgM level (HP:0003496)3.55184914
13Acute necrotizing encephalopathy (HP:0006965)3.39867134
14Abnormal mitochondria in muscle tissue (HP:0008316)3.25866868
15Increased intramyocellular lipid droplets (HP:0012240)3.25185886
16Abnormality of T cells (HP:0002843)3.24435260
173-Methylglutaconic aciduria (HP:0003535)3.21859247
18Abnormal rod and cone electroretinograms (HP:0008323)3.21731176
19Hepatocellular necrosis (HP:0001404)3.06654377
20Increased hepatocellular lipid droplets (HP:0006565)3.04835407
21Abnormality of B cell number (HP:0010975)3.03589169
22Thyroiditis (HP:0100646)2.98561442
23Increased CSF lactate (HP:0002490)2.97620843
24Stomatitis (HP:0010280)2.97130831
25Combined immunodeficiency (HP:0005387)2.85393031
26Renal Fanconi syndrome (HP:0001994)2.76444055
27Progressive macrocephaly (HP:0004481)2.75352562
28Attenuation of retinal blood vessels (HP:0007843)2.75201336
29Pancreatic cysts (HP:0001737)2.72231965
30Hepatic necrosis (HP:0002605)2.70997463
31Decreased central vision (HP:0007663)2.67842072
32Encephalitis (HP:0002383)2.59725853
33Acute encephalopathy (HP:0006846)2.57631075
34Increased muscle lipid content (HP:0009058)2.57057988
35Lipid accumulation in hepatocytes (HP:0006561)2.56863071
36Chronic diarrhea (HP:0002028)2.49523720
37Abnormality of eosinophils (HP:0001879)2.47352715
38Abolished electroretinogram (ERG) (HP:0000550)2.47301269
39Pancytopenia (HP:0001876)2.45978965
40Reduced antithrombin III activity (HP:0001976)2.44181915
41Abnormality of the prostate (HP:0008775)2.43496091
42B lymphocytopenia (HP:0010976)2.42044149
43True hermaphroditism (HP:0010459)2.40383112
44Hypoalbuminemia (HP:0003073)2.38009519
45Abnormal albumin level (HP:0012116)2.38009519
46Cerebral edema (HP:0002181)2.37037377
47Constricted visual fields (HP:0001133)2.35225395
48Oral leukoplakia (HP:0002745)2.34167807
49Generalized aminoaciduria (HP:0002909)2.33042056
50Decreased electroretinogram (ERG) amplitude (HP:0000654)2.26870770
51Pancreatic fibrosis (HP:0100732)2.24605419
52Lymphopenia (HP:0001888)2.21904079
53Exertional dyspnea (HP:0002875)2.20805066
54Molar tooth sign on MRI (HP:0002419)2.17048879
55Abnormality of midbrain morphology (HP:0002418)2.17048879
56Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.15829004
57Decreased activity of mitochondrial respiratory chain (HP:0008972)2.15829004
58Optic disc pallor (HP:0000543)2.13711296
59Methylmalonic acidemia (HP:0002912)2.13298060
60Autoimmune thrombocytopenia (HP:0001973)2.12684453
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.12054726
62Abnormality of cells of the lymphoid lineage (HP:0012140)2.08958615
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05536390
64Cerebral palsy (HP:0100021)2.05007378
65Pendular nystagmus (HP:0012043)2.04020007
66Leukocytosis (HP:0001974)2.03386822
67Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.00335130
68Recurrent cutaneous fungal infections (HP:0011370)1.98854196
69Chronic mucocutaneous candidiasis (HP:0002728)1.98854196
70Severe visual impairment (HP:0001141)1.98368922
71Eosinophilia (HP:0001880)1.97303455
72Abnormality of T cell physiology (HP:0011840)1.97302998
73Increased serum lactate (HP:0002151)1.96899177
74Methylmalonic aciduria (HP:0012120)1.96824903
75Abnormality of the renal cortex (HP:0011035)1.93944303
76Renal cortical cysts (HP:0000803)1.93253359
77Radial bowing (HP:0002986)1.89792211
78Abnormal number of erythroid precursors (HP:0012131)1.89502873
79Lactic acidosis (HP:0003128)1.89021250
80Recurrent bronchitis (HP:0002837)1.88625082
81Keratoconus (HP:0000563)1.88595596
82Increased corneal curvature (HP:0100692)1.88595596
83Type I transferrin isoform profile (HP:0003642)1.86536684
84Alkalosis (HP:0001948)1.85212037
85IgM deficiency (HP:0002850)1.84276716
86Abnormality of macrophages (HP:0004311)1.83180349
87Agammaglobulinemia (HP:0004432)1.82887101
88Abnormality of cells of the erythroid lineage (HP:0012130)1.81980120
89Lymphoma (HP:0002665)1.80815755
90Parakeratosis (HP:0001036)1.80501628
91Hypoplasia of the thymus (HP:0000778)1.79916758
92Type 2 muscle fiber atrophy (HP:0003554)1.79181817
93Reticulocytopenia (HP:0001896)1.79154780
94Hyperphosphaturia (HP:0003109)1.77784851
95Absent thumb (HP:0009777)1.77501775
96Symphalangism affecting the phalanges of the hand (HP:0009773)1.75611634
97Respiratory failure (HP:0002878)1.75496236
98Myositis (HP:0100614)1.74761050
99Hypergammaglobulinemia (HP:0010702)1.72611499
100Abnormal glycosylation (HP:0012345)1.72577792

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.73059309
2TESK25.29270871
3TXK4.82283301
4BCKDK2.93391980
5MAP4K12.57124170
6VRK22.44170311
7MAP4K22.32836964
8ZAK2.28899411
9TESK12.27022144
10ADRBK22.21029340
11GRK12.11158459
12ITK2.09545840
13SCYL22.09144828
14CDK191.99042340
15TLK11.88725393
16LIMK11.74166263
17GRK61.71419070
18PASK1.68401636
19TEC1.66422036
20VRK11.60296797
21TAOK31.54226405
22TNK21.53335134
23SYK1.51831249
24FES1.50148912
25BTK1.40039602
26NME11.38134212
27MUSK1.35720021
28PINK11.32873045
29FRK1.32687706
30MAP3K111.26914431
31ZAP701.24030963
32TIE11.17940212
33CSK1.17641930
34NUAK11.15951561
35LCK1.11670648
36CAMKK21.09268750
37PRKCQ1.04286823
38GRK71.02672919
39MAP3K120.94378370
40DAPK20.94350060
41LYN0.89748182
42IKBKE0.89228688
43PIK3CG0.86361248
44INSRR0.84620677
45CAMKK10.84402114
46DAPK10.81673738
47MST40.80067903
48MYLK0.77815893
49RPS6KA50.73722561
50KIT0.70792953
51BUB10.70490254
52PIM10.67432967
53EIF2AK30.67179290
54OBSCN0.65103715
55RPS6KA40.63983421
56ERBB30.63544285
57WNK30.59957097
58IKBKB0.57633709
59JAK30.53949036
60ROCK10.53830584
61DAPK30.53449364
62CSF1R0.53124320
63WNK40.52454801
64ADRBK10.50844959
65RIPK40.50619548
66IGF1R0.50300935
67HCK0.48789775
68FYN0.47775867
69AURKA0.46189684
70MAP2K70.43880891
71STK160.43757295
72TRPM70.43387672
73PRKCA0.43363440
74BMPR20.43058828
75PRKACA0.41941660
76PIM20.41644186
77OXSR10.41412105
78INSR0.40121598
79CSNK1G30.38143114
80GRK50.37151542
81MAP2K60.36602926
82MATK0.34692397
83LRRK20.34139720
84CSNK2A10.34040099
85MAPKAPK50.33597643
86MAP3K50.31373419
87MAPK130.30452798
88MAP3K40.30077253
89CAMK2A0.29305306
90CSNK2A20.27899346
91CAMK10.27003218
92BMPR1B0.26516448
93PIK3CA0.25309689
94MARK30.24408311
95MAPK150.23799872
96TBK10.23714691
97PAK10.23663731
98PRKCB0.23313042
99ABL10.21987863
100MAPK110.21807661

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.58877243
2Proteasome_Homo sapiens_hsa030504.29195993
3Oxidative phosphorylation_Homo sapiens_hsa001903.42225338
4Ribosome_Homo sapiens_hsa030103.06158836
5Parkinsons disease_Homo sapiens_hsa050122.78037610
6Antigen processing and presentation_Homo sapiens_hsa046122.69189445
7Graft-versus-host disease_Homo sapiens_hsa053322.65065373
8Autoimmune thyroid disease_Homo sapiens_hsa053202.54455026
9Hematopoietic cell lineage_Homo sapiens_hsa046402.50524237
10Allograft rejection_Homo sapiens_hsa053302.49644058
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.04341272
12Type I diabetes mellitus_Homo sapiens_hsa049402.01395649
13T cell receptor signaling pathway_Homo sapiens_hsa046601.99328872
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98074746
15RNA polymerase_Homo sapiens_hsa030201.91743409
16Phototransduction_Homo sapiens_hsa047441.84233659
17Alzheimers disease_Homo sapiens_hsa050101.79698144
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.67817974
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63627491
20Cardiac muscle contraction_Homo sapiens_hsa042601.61323326
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.61204816
22Huntingtons disease_Homo sapiens_hsa050161.60441234
23Rheumatoid arthritis_Homo sapiens_hsa053231.38319695
24Protein export_Homo sapiens_hsa030601.37548200
25Nitrogen metabolism_Homo sapiens_hsa009101.36680340
26Asthma_Homo sapiens_hsa053101.34374297
27Linoleic acid metabolism_Homo sapiens_hsa005911.20548918
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19735217
29Caffeine metabolism_Homo sapiens_hsa002321.18072286
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17531962
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.16598609
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16397468
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15061882
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12192868
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08714997
36Malaria_Homo sapiens_hsa051441.07412794
37Measles_Homo sapiens_hsa051621.06629568
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.05023623
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00357382
40Retinol metabolism_Homo sapiens_hsa008300.99857369
41Viral myocarditis_Homo sapiens_hsa054160.97595381
42Chemical carcinogenesis_Homo sapiens_hsa052040.96861098
43Peroxisome_Homo sapiens_hsa041460.94620289
44Olfactory transduction_Homo sapiens_hsa047400.93792843
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90394355
46Homologous recombination_Homo sapiens_hsa034400.89922312
47Butanoate metabolism_Homo sapiens_hsa006500.86886648
48Pyrimidine metabolism_Homo sapiens_hsa002400.86335053
49RNA degradation_Homo sapiens_hsa030180.82311047
50Systemic lupus erythematosus_Homo sapiens_hsa053220.81665690
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78200224
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74775313
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.74200557
54One carbon pool by folate_Homo sapiens_hsa006700.73364308
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67256607
56Purine metabolism_Homo sapiens_hsa002300.65432395
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61274505
58Taste transduction_Homo sapiens_hsa047420.59817232
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55136109
60Propanoate metabolism_Homo sapiens_hsa006400.54389317
61Shigellosis_Homo sapiens_hsa051310.53938564
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.53688284
63Salmonella infection_Homo sapiens_hsa051320.52250591
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50725561
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50557248
66Sulfur metabolism_Homo sapiens_hsa009200.49063624
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48527597
68Nicotine addiction_Homo sapiens_hsa050330.47861043
69ABC transporters_Homo sapiens_hsa020100.46097694
70Collecting duct acid secretion_Homo sapiens_hsa049660.46074662
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45710402
72Basal transcription factors_Homo sapiens_hsa030220.45592581
73Metabolic pathways_Homo sapiens_hsa011000.44770395
74Spliceosome_Homo sapiens_hsa030400.44539482
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43765397
76Fanconi anemia pathway_Homo sapiens_hsa034600.40794610
77Arachidonic acid metabolism_Homo sapiens_hsa005900.40620427
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40410722
79Tryptophan metabolism_Homo sapiens_hsa003800.40246174
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.39310892
81Regulation of autophagy_Homo sapiens_hsa041400.39235502
82Staphylococcus aureus infection_Homo sapiens_hsa051500.38686938
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37871955
84Nucleotide excision repair_Homo sapiens_hsa034200.37071868
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.35754737
86Herpes simplex infection_Homo sapiens_hsa051680.35511175
87Ether lipid metabolism_Homo sapiens_hsa005650.34657609
88Morphine addiction_Homo sapiens_hsa050320.33763095
89Ovarian steroidogenesis_Homo sapiens_hsa049130.32869518
90RNA transport_Homo sapiens_hsa030130.26424217
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25123378
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22501418
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20835915
94Salivary secretion_Homo sapiens_hsa049700.18731606
95Fat digestion and absorption_Homo sapiens_hsa049750.17232420
96Tyrosine metabolism_Homo sapiens_hsa003500.16434032
97African trypanosomiasis_Homo sapiens_hsa051430.15278916
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.15026074
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.14528629
100Base excision repair_Homo sapiens_hsa034100.14035326

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