ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.66086983
2	viral transcription (GO:0019083)	6.37053009
3	ribosomal small subunit biogenesis (GO:0042274)	6.24638621
4	translational termination (GO:0006415)	6.11416377
5	maturation of SSU-rRNA (GO:0030490)	5.78993908
6	DNA deamination (GO:0045006)	5.73488286
7	ATP synthesis coupled proton transport (GO:0015986)	5.60757912
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.60757912
9	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.43540526
10	translational elongation (GO:0006414)	5.38169176
11	cotranslational protein targeting to membrane (GO:0006613)	5.35655882
12	protein targeting to ER (GO:0045047)	5.29314587
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.13235650
14	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.04930344
15	protein localization to endoplasmic reticulum (GO:0070972)	5.01474407
16	chaperone-mediated protein transport (GO:0072321)	4.74912085
17	viral life cycle (GO:0019058)	4.60661009
18	cellular protein complex disassembly (GO:0043624)	4.54839614
19	ribosomal large subunit biogenesis (GO:0042273)	4.54779681
20	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.44478758
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.40715462
22	translational initiation (GO:0006413)	4.25982139
23	protein neddylation (GO:0045116)	4.21475802
24	behavioral response to nicotine (GO:0035095)	4.20160573
25	respiratory electron transport chain (GO:0022904)	4.08311163
26	electron transport chain (GO:0022900)	4.05496033
27	translation (GO:0006412)	4.00544315
28	protein complex biogenesis (GO:0070271)	3.97372534
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.93161220
30	NADH dehydrogenase complex assembly (GO:0010257)	3.93161220
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.93161220
32	water-soluble vitamin biosynthetic process (GO:0042364)	3.76417331
33	protein complex disassembly (GO:0043241)	3.73824375
34	ribonucleoprotein complex biogenesis (GO:0022613)	3.72866343
35	cellular component biogenesis (GO:0044085)	3.72468770
36	pseudouridine synthesis (GO:0001522)	3.71898619
37	protein-cofactor linkage (GO:0018065)	3.63737695
38	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.60742973
39	mitochondrial respiratory chain complex assembly (GO:0033108)	3.60558631
40	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.57391592
41	macromolecular complex disassembly (GO:0032984)	3.55545834
42	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.55295836
43	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.54697635
44	protein targeting to membrane (GO:0006612)	3.50542401
45	GTP biosynthetic process (GO:0006183)	3.42068148
46	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.42046524
47	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.41104792
48	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.41104792
49	positive regulation of prostaglandin secretion (GO:0032308)	3.40750416
50	respiratory chain complex IV assembly (GO:0008535)	3.30677479
51	male meiosis I (GO:0007141)	3.24654781
52	mRNA catabolic process (GO:0006402)	3.24131504
53	rRNA processing (GO:0006364)	3.23683111
54	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.21556622
55	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.20435150
56	rRNA metabolic process (GO:0016072)	3.19705267
57	piRNA metabolic process (GO:0034587)	3.18669379
58	ATP biosynthetic process (GO:0006754)	3.15079297
59	negative regulation of telomere maintenance (GO:0032205)	3.11763894
60	preassembly of GPI anchor in ER membrane (GO:0016254)	3.07220574
61	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.05434501
62	termination of RNA polymerase III transcription (GO:0006386)	3.05434501
63	cytidine metabolic process (GO:0046087)	3.04200870
64	cytidine catabolic process (GO:0006216)	3.04200870
65	cytidine deamination (GO:0009972)	3.04200870
66	hydrogen ion transmembrane transport (GO:1902600)	3.03768147
67	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.00187534
68	platelet dense granule organization (GO:0060155)	2.99988860
69	cytochrome complex assembly (GO:0017004)	2.95835889
70	rRNA modification (GO:0000154)	2.94344744
71	regulation of cilium movement (GO:0003352)	2.93971533
72	RNA catabolic process (GO:0006401)	2.92022165
73	resolution of meiotic recombination intermediates (GO:0000712)	2.90028839
74	UTP biosynthetic process (GO:0006228)	2.87772901
75	proton transport (GO:0015992)	2.85588176
76	proteasome assembly (GO:0043248)	2.85465651
77	tRNA processing (GO:0008033)	2.85218957
78	positive regulation of fatty acid transport (GO:2000193)	2.82369571
79	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.81544660
80	peptidyl-histidine modification (GO:0018202)	2.81010362
81	hydrogen transport (GO:0006818)	2.78729299
82	mannosylation (GO:0097502)	2.78267595
83	protein targeting to mitochondrion (GO:0006626)	2.74198703
84	kynurenine metabolic process (GO:0070189)	2.73377078
85	intracellular protein transmembrane import (GO:0044743)	2.70899888
86	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.70824811
87	ubiquinone biosynthetic process (GO:0006744)	2.69779485
88	regulation of mitochondrial translation (GO:0070129)	2.69139809
89	protein polyglutamylation (GO:0018095)	2.67947284
90	establishment of protein localization to mitochondrion (GO:0072655)	2.67074475
91	replication fork processing (GO:0031297)	2.65859401
92	positive regulation of icosanoid secretion (GO:0032305)	2.64796338
93	UTP metabolic process (GO:0046051)	2.63193552
94	chromatin remodeling at centromere (GO:0031055)	2.60414774
95	ncRNA 3-end processing (GO:0043628)	2.60384929
96	tryptophan catabolic process (GO:0006569)	2.60046764
97	indole-containing compound catabolic process (GO:0042436)	2.60046764
98	indolalkylamine catabolic process (GO:0046218)	2.60046764
99	male meiosis (GO:0007140)	2.59264683
100	regulation of prostaglandin secretion (GO:0032306)	2.58275911

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.58675051
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.22435550
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.61238786
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.55447541
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.37517721
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.26492635
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.06757176
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.86105054
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.68236978
10	VDR_22108803_ChIP-Seq_LS180_Human	2.64492634
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.55117258
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.51520261
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.50690231
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.50677058
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.29967544
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.25535498
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.23265656
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.21123358
19	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.11951068
20	ELK1_19687146_ChIP-ChIP_HELA_Human	2.11821388
21	FOXP3_21729870_ChIP-Seq_TREG_Human	2.11635225
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.98736911
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.97343103
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.89909771
25	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.89690338
26	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.89121195
27	TTF2_22483619_ChIP-Seq_HELA_Human	1.67824605
28	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.65767313
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.63328010
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.61853029
31	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.59523550
32	GABP_19822575_ChIP-Seq_HepG2_Human	1.55590414
33	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53875126
34	EWS_26573619_Chip-Seq_HEK293_Human	1.47403273
35	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.43655296
36	FUS_26573619_Chip-Seq_HEK293_Human	1.42799070
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39099942
38	XRN2_22483619_ChIP-Seq_HELA_Human	1.37204120
39	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.36693279
40	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.36542441
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.35845046
42	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.29488748
43	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.29175660
44	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.28309808
45	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.27687713
46	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.26777273
47	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.24671330
48	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.24654551
49	IGF1R_20145208_ChIP-Seq_DFB_Human	1.21156596
50	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.20884377
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20355218
52	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.20228606
53	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.18090486
54	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.16869723
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16002248
56	DCP1A_22483619_ChIP-Seq_HELA_Human	1.14671647
57	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12761503
58	AR_20517297_ChIP-Seq_VCAP_Human	1.12360423
59	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12255153
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12255153
61	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.11675619
62	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.11127598
63	NCOR_22424771_ChIP-Seq_293T_Human	1.10755080
64	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.10717586
65	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10626914
66	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.10428410
67	NANOG_20526341_ChIP-Seq_ESCs_Human	1.10138353
68	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.06445656
69	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.06377891
70	TAF2_19829295_ChIP-Seq_ESCs_Human	1.05666302
71	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.05264571
72	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.03809403
73	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.03725166
74	ERA_21632823_ChIP-Seq_H3396_Human	1.03236649
75	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.03012800
76	ER_23166858_ChIP-Seq_MCF-7_Human	1.02238757
77	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99859460
78	RNF2_27304074_Chip-Seq_NSC_Mouse	0.99518326
79	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.99316855
80	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.99151818
81	MYC_19829295_ChIP-Seq_ESCs_Human	0.98578533
82	P53_21459846_ChIP-Seq_SAOS-2_Human	0.97942663
83	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.97786736
84	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.97388477
85	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.96456915
86	HOXB7_26014856_ChIP-Seq_BT474_Human	0.95251448
87	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.94600373
88	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.94595132
89	SOX2_19829295_ChIP-Seq_ESCs_Human	0.94486804
90	NANOG_19829295_ChIP-Seq_ESCs_Human	0.94486804
91	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.92542004
92	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.90795760
93	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.89801088
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.89164831
95	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.89077643
96	STAT1_20625510_ChIP-Seq_HELA_Human	0.86776008
97	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.86458448
98	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.83789112
99	P300_19829295_ChIP-Seq_ESCs_Human	0.83050335
100	GATA3_26560356_Chip-Seq_TH2_Human	0.82640961

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.77637335
2	MP0006292_abnormal_olfactory_placode	4.46056058
3	MP0008877_abnormal_DNA_methylation	3.37612619
4	MP0002102_abnormal_ear_morphology	2.48136689
5	MP0008789_abnormal_olfactory_epithelium	2.43071977
6	MP0004147_increased_porphyrin_level	2.18027791
7	MP0002163_abnormal_gland_morphology	2.17571089
8	MP0005646_abnormal_pituitary_gland	2.12117780
9	MP0005671_abnormal_response_to	2.07953790
10	MP0008058_abnormal_DNA_repair	2.07023908
11	MP0004885_abnormal_endolymph	2.06436145
12	MP0002138_abnormal_hepatobiliary_system	2.05742054
13	MP0008875_abnormal_xenobiotic_pharmacok	2.04300083
14	MP0003787_abnormal_imprinting	2.01442134
15	MP0003786_premature_aging	1.90666677
16	MP0008995_early_reproductive_senescence	1.85347661
17	MP0006072_abnormal_retinal_apoptosis	1.76314829
18	MP0003878_abnormal_ear_physiology	1.75986307
19	MP0005377_hearing/vestibular/ear_phenot	1.75986307
20	MP0000372_irregular_coat_pigmentation	1.75194093
21	MP0003646_muscle_fatigue	1.73584497
22	MP0002938_white_spotting	1.71398550
23	MP0005551_abnormal_eye_electrophysiolog	1.70682245
24	MP0002277_abnormal_respiratory_mucosa	1.70110775
25	MP0005645_abnormal_hypothalamus_physiol	1.69549947
26	MP0004142_abnormal_muscle_tone	1.65849577
27	MP0005499_abnormal_olfactory_system	1.62639245
28	MP0005394_taste/olfaction_phenotype	1.62639245
29	MP0001293_anophthalmia	1.59335473
30	MP0002160_abnormal_reproductive_system	1.58965839
31	MP0005389_reproductive_system_phenotype	1.56184175
32	MP0008872_abnormal_physiological_respon	1.52830086
33	MP0001986_abnormal_taste_sensitivity	1.51325093
34	MP0002095_abnormal_skin_pigmentation	1.50033904
35	MP0002876_abnormal_thyroid_physiology	1.48901107
36	MP0001485_abnormal_pinna_reflex	1.47897299
37	MP0002736_abnormal_nociception_after	1.43643706
38	MP0002837_dystrophic_cardiac_calcinosis	1.43368791
39	MP0005084_abnormal_gallbladder_morpholo	1.41860728
40	MP0003195_calcinosis	1.40344506
41	MP0004145_abnormal_muscle_electrophysio	1.38302473
42	MP0001529_abnormal_vocalization	1.31946224
43	MP0002638_abnormal_pupillary_reflex	1.31545000
44	MP0002234_abnormal_pharynx_morphology	1.31287529
45	MP0002210_abnormal_sex_determination	1.30190221
46	MP0001968_abnormal_touch/_nociception	1.29112841
47	MP0001905_abnormal_dopamine_level	1.28413532
48	MP0000631_abnormal_neuroendocrine_gland	1.26697742
49	MP0002653_abnormal_ependyma_morphology	1.25875201
50	MP0003806_abnormal_nucleotide_metabolis	1.22366443
51	MP0003186_abnormal_redox_activity	1.21691730
52	MP0005379_endocrine/exocrine_gland_phen	1.20457226
53	MP0001919_abnormal_reproductive_system	1.20231470
54	MP0006276_abnormal_autonomic_nervous	1.19876676
55	MP0006036_abnormal_mitochondrial_physio	1.19418789
56	MP0000049_abnormal_middle_ear	1.17372618
57	MP0001984_abnormal_olfaction	1.17011442
58	MP0003693_abnormal_embryo_hatching	1.16342069
59	MP0001764_abnormal_homeostasis	1.14469357
60	MP0003718_maternal_effect	1.13377534
61	MP0004742_abnormal_vestibular_system	1.10131016
62	MP0003123_paternal_imprinting	1.09207752
63	MP0002272_abnormal_nervous_system	1.07662659
64	MP0005410_abnormal_fertilization	1.07575334
65	MP0005174_abnormal_tail_pigmentation	1.07383912
66	MP0003011_delayed_dark_adaptation	1.03700809
67	MP0009333_abnormal_splenocyte_physiolog	1.02567255
68	MP0003121_genomic_imprinting	1.00787861
69	MP0005075_abnormal_melanosome_morpholog	0.99887888
70	MP0000026_abnormal_inner_ear	0.98755664
71	MP0001929_abnormal_gametogenesis	0.98506038
72	MP0000653_abnormal_sex_gland	0.98222943
73	MP0001145_abnormal_male_reproductive	0.97152179
74	MP0001119_abnormal_female_reproductive	0.94955564
75	MP0005253_abnormal_eye_physiology	0.93196206
76	MP0009046_muscle_twitch	0.92639777
77	MP0000427_abnormal_hair_cycle	0.92076232
78	MP0001963_abnormal_hearing_physiology	0.91492194
79	MP0003938_abnormal_ear_development	0.89853233
80	MP0000685_abnormal_immune_system	0.86303848
81	MP0005195_abnormal_posterior_eye	0.84622734
82	MP0003936_abnormal_reproductive_system	0.83562941
83	MP0001835_abnormal_antigen_presentation	0.81053778
84	MP0003698_abnormal_male_reproductive	0.79481982
85	MP0009745_abnormal_behavioral_response	0.76166158
86	MP0002148_abnormal_hypersensitivity_rea	0.74886352
87	MP0003136_yellow_coat_color	0.73546323
88	MP0002752_abnormal_somatic_nervous	0.72947735
89	MP0003567_abnormal_fetal_cardiomyocyte	0.72738203
90	MP0006035_abnormal_mitochondrial_morpho	0.72702985
91	MP0001188_hyperpigmentation	0.71423442
92	MP0001502_abnormal_circadian_rhythm	0.70876815
93	MP0003880_abnormal_central_pattern	0.70739400
94	MP0003122_maternal_imprinting	0.70406189
95	MP0005636_abnormal_mineral_homeostasis	0.69825727
96	MP0001486_abnormal_startle_reflex	0.69585577
97	MP0010094_abnormal_chromosome_stability	0.69320680
98	MP0002184_abnormal_innervation	0.67360588
99	MP0002693_abnormal_pancreas_physiology	0.67272465
100	MP0002233_abnormal_nose_morphology	0.65640687

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.68325037
2	Acute necrotizing encephalopathy (HP:0006965)	4.67514624
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.59911843
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.14433281
5	Abnormal number of erythroid precursors (HP:0012131)	4.14202078
6	Mitochondrial inheritance (HP:0001427)	4.02822626
7	Acute encephalopathy (HP:0006846)	4.00689969
8	Progressive macrocephaly (HP:0004481)	3.82230994
9	Increased CSF lactate (HP:0002490)	3.64912743
10	3-Methylglutaconic aciduria (HP:0003535)	3.53457189
11	Congenital stationary night blindness (HP:0007642)	3.49470543
12	Pancreatic fibrosis (HP:0100732)	3.35493546
13	Macrocytic anemia (HP:0001972)	3.33676754
14	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.30011068
15	Abnormal rod and cone electroretinograms (HP:0008323)	3.28073010
16	Pancreatic cysts (HP:0001737)	3.23266501
17	Cerebral edema (HP:0002181)	3.22821161
18	Molar tooth sign on MRI (HP:0002419)	3.15475878
19	Abnormality of midbrain morphology (HP:0002418)	3.15475878
20	Increased hepatocellular lipid droplets (HP:0006565)	3.12208407
21	True hermaphroditism (HP:0010459)	3.07435560
22	Lipid accumulation in hepatocytes (HP:0006561)	2.97185830
23	Hepatocellular necrosis (HP:0001404)	2.89505394
24	Renal Fanconi syndrome (HP:0001994)	2.86536572
25	Pallor (HP:0000980)	2.83973081
26	Colon cancer (HP:0003003)	2.83646655
27	Hepatic necrosis (HP:0002605)	2.81879305
28	Nephronophthisis (HP:0000090)	2.78287460
29	Septo-optic dysplasia (HP:0100842)	2.75611075
30	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.65179774
31	Absent thumb (HP:0009777)	2.55927499
32	Increased serum lactate (HP:0002151)	2.55836091
33	Optic disc pallor (HP:0000543)	2.54587054
34	Lactic acidosis (HP:0003128)	2.46210399
35	Pendular nystagmus (HP:0012043)	2.41892899
36	Abnormality of the renal cortex (HP:0011035)	2.39755607
37	Decreased central vision (HP:0007663)	2.39303934
38	Abnormality of the renal medulla (HP:0100957)	2.39130242
39	Sclerocornea (HP:0000647)	2.36882272
40	Abnormality of DNA repair (HP:0003254)	2.35813197
41	Increased intramyocellular lipid droplets (HP:0012240)	2.35479339
42	Methylmalonic aciduria (HP:0012120)	2.31936797
43	Methylmalonic acidemia (HP:0002912)	2.29473872
44	Attenuation of retinal blood vessels (HP:0007843)	2.27113225
45	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.25744040
46	Microvesicular hepatic steatosis (HP:0001414)	2.23723762
47	Medial flaring of the eyebrow (HP:0010747)	2.23404693
48	Abolished electroretinogram (ERG) (HP:0000550)	2.23148849
49	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.22384308
50	Tubular atrophy (HP:0000092)	2.18029679
51	Asplenia (HP:0001746)	2.17001551
52	Rib fusion (HP:0000902)	2.16670534
53	Exertional dyspnea (HP:0002875)	2.09081580
54	Type II lissencephaly (HP:0007260)	2.08698344
55	Polydipsia (HP:0001959)	2.08644970
56	Abnormal drinking behavior (HP:0030082)	2.08644970
57	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.05437136
58	Exercise intolerance (HP:0003546)	2.04703253
59	Respiratory failure (HP:0002878)	2.02991358
60	Type 2 muscle fiber atrophy (HP:0003554)	2.02444734
61	Cystic liver disease (HP:0006706)	1.98669674
62	Lethargy (HP:0001254)	1.97333463
63	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.95749143
64	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.95749143
65	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.95607065
66	Optic nerve hypoplasia (HP:0000609)	1.95487416
67	Aplastic anemia (HP:0001915)	1.95008182
68	Increased muscle lipid content (HP:0009058)	1.94640299
69	Polyuria (HP:0000103)	1.93720827
70	Absent/shortened dynein arms (HP:0200106)	1.92876932
71	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.92876932
72	Absent septum pellucidum (HP:0001331)	1.92733776
73	Ketosis (HP:0001946)	1.89432278
74	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.88009407
75	Postaxial foot polydactyly (HP:0001830)	1.85604639
76	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.83589335
77	Congenital, generalized hypertrichosis (HP:0004540)	1.83115880
78	Abnormality of urine glucose concentration (HP:0011016)	1.82992965
79	Glycosuria (HP:0003076)	1.82992965
80	Triphalangeal thumb (HP:0001199)	1.81412504
81	Male pseudohermaphroditism (HP:0000037)	1.81175213
82	IgG deficiency (HP:0004315)	1.80271965
83	Dicarboxylic aciduria (HP:0003215)	1.80147251
84	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.80147251
85	Anencephaly (HP:0002323)	1.79834954
86	Testicular atrophy (HP:0000029)	1.79544937
87	Abnormality of renal resorption (HP:0011038)	1.79136700
88	Constricted visual fields (HP:0001133)	1.78772129
89	Stomatitis (HP:0010280)	1.74713086
90	Pancytopenia (HP:0001876)	1.73929586
91	Hyperthyroidism (HP:0000836)	1.72836821
92	Hyperglycinemia (HP:0002154)	1.72787932
93	Depressed nasal ridge (HP:0000457)	1.71657179
94	Adrenal hypoplasia (HP:0000835)	1.69308428
95	Increased IgM level (HP:0003496)	1.68990978
96	Abnormal biliary tract physiology (HP:0012439)	1.68826952
97	Bile duct proliferation (HP:0001408)	1.68826952
98	Type I transferrin isoform profile (HP:0003642)	1.68776800
99	Leukodystrophy (HP:0002415)	1.67163556
100	Maternal diabetes (HP:0009800)	1.66217483

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	2.99875362
2	VRK2	2.98093013
3	BCKDK	2.81393615
4	STK16	2.76005250
5	TXK	2.60569383
6	TLK1	2.57126566
7	ADRBK2	2.47489863
8	WNK4	2.33709998
9	NUAK1	2.21567280
10	PINK1	2.18658241
11	GRK1	2.12163809
12	BUB1	2.10661643
13	PASK	1.98112629
14	WNK3	1.87341541
15	FRK	1.80766680
16	PLK4	1.74203677
17	TAOK3	1.72788982
18	NME2	1.69703496
19	TIE1	1.69237495
20	VRK1	1.62457991
21	STK39	1.58467221
22	BMPR1B	1.58384636
23	CDK19	1.57081268
24	MAP4K2	1.50377192
25	KDR	1.50332597
26	NEK1	1.43195289
27	DYRK2	1.42832678
28	CAMKK2	1.38443820
29	PDK2	1.29808847
30	TEC	1.25411632
31	CDC7	1.18207855
32	NME1	1.14340969
33	OXSR1	1.09956781
34	BRSK2	1.05004613
35	MST4	1.03482980
36	IKBKB	1.02119818
37	PIK3CA	1.01003924
38	MUSK	0.98122667
39	MAP3K12	0.95625444
40	ITK	0.93379577
41	PRKCQ	0.84482104
42	AKT3	0.84278112
43	LIMK1	0.83779137
44	PLK1	0.82839684
45	ADRBK1	0.77922655
46	PLK2	0.77455591
47	PTK2B	0.77039296
48	BRSK1	0.76388384
49	PLK3	0.75703371
50	PRKCG	0.75144352
51	RPS6KA5	0.72986142
52	CAMK1	0.71923030
53	EPHA4	0.71659785
54	EIF2AK1	0.70717869
55	AURKB	0.68498634
56	LRRK2	0.67837952
57	ATR	0.67744203
58	BRAF	0.66484125
59	CSNK1G3	0.64665864
60	TNK2	0.63897678
61	TAF1	0.63756452
62	MAP3K11	0.62518571
63	MAP4K1	0.61717836
64	BTK	0.61631715
65	INSRR	0.61620093
66	MAPK13	0.61196466
67	CSNK2A2	0.60016765
68	GRK7	0.58132415
69	MKNK1	0.57895926
70	WEE1	0.55756386
71	DAPK3	0.55734873
72	AURKA	0.55626473
73	MAPKAPK5	0.53137390
74	MYLK	0.52902845
75	CSNK1G2	0.51551426
76	NEK2	0.51432553
77	PRKCI	0.51232805
78	CSNK1G1	0.51119359
79	PHKG1	0.50237746
80	PHKG2	0.50237746
81	TNIK	0.49911293
82	CSNK2A1	0.49682245
83	PAK3	0.49570329
84	PRKACA	0.48839075
85	GRK6	0.47871322
86	ABL2	0.46221019
87	OBSCN	0.44799383
88	TESK2	0.44394390
89	CDK8	0.43786581
90	TSSK6	0.41772393
91	WNK1	0.41246508
92	CAMKK1	0.40471820
93	DAPK1	0.39939644
94	PRKCA	0.39642216
95	SYK	0.39018085
96	STK11	0.36605548
97	MAP2K2	0.36475725
98	CSNK1E	0.36414822
99	IGF1R	0.35911690
100	TRIM28	0.34208159

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.57350184
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.01712258
3	Parkinsons disease_Homo sapiens_hsa05012	3.37654516
4	Proteasome_Homo sapiens_hsa03050	3.00405360
5	RNA polymerase_Homo sapiens_hsa03020	2.75983304
6	Protein export_Homo sapiens_hsa03060	2.38017651
7	Huntingtons disease_Homo sapiens_hsa05016	2.32644342
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.29901271
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.12931286
10	Alzheimers disease_Homo sapiens_hsa05010	2.12768641
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.06263430
12	Homologous recombination_Homo sapiens_hsa03440	2.04869117
13	Cardiac muscle contraction_Homo sapiens_hsa04260	1.99700517
14	RNA degradation_Homo sapiens_hsa03018	1.75066318
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.72771800
16	One carbon pool by folate_Homo sapiens_hsa00670	1.70388615
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.68251592
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.67637839
19	Mismatch repair_Homo sapiens_hsa03430	1.67412694
20	Basal transcription factors_Homo sapiens_hsa03022	1.66793366
21	Primary immunodeficiency_Homo sapiens_hsa05340	1.62155125
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.60630872
23	Phototransduction_Homo sapiens_hsa04744	1.58583186
24	Pyrimidine metabolism_Homo sapiens_hsa00240	1.53471903
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.50117014
26	Asthma_Homo sapiens_hsa05310	1.50103349
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.45083380
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.37108765
29	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.36026241
30	Sulfur relay system_Homo sapiens_hsa04122	1.33425845
31	DNA replication_Homo sapiens_hsa03030	1.33106779
32	Allograft rejection_Homo sapiens_hsa05330	1.32894517
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.23371852
34	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.20455122
35	Spliceosome_Homo sapiens_hsa03040	1.17102740
36	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.16349437
37	Purine metabolism_Homo sapiens_hsa00230	1.16322078
38	Peroxisome_Homo sapiens_hsa04146	1.15748934
39	RNA transport_Homo sapiens_hsa03013	1.12809352
40	Propanoate metabolism_Homo sapiens_hsa00640	1.10688390
41	Butanoate metabolism_Homo sapiens_hsa00650	1.07764494
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.07625314
43	Base excision repair_Homo sapiens_hsa03410	1.06550773
44	Type I diabetes mellitus_Homo sapiens_hsa04940	1.06156723
45	Graft-versus-host disease_Homo sapiens_hsa05332	1.05929415
46	Sulfur metabolism_Homo sapiens_hsa00920	1.05068006
47	Caffeine metabolism_Homo sapiens_hsa00232	0.93411911
48	Tryptophan metabolism_Homo sapiens_hsa00380	0.92134528
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.91155152
50	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.90414743
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.88109501
52	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.87792244
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.85254482
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.83008358
55	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.82872510
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78454683
57	Metabolic pathways_Homo sapiens_hsa01100	0.75226897
58	Selenocompound metabolism_Homo sapiens_hsa00450	0.73359777
59	Antigen processing and presentation_Homo sapiens_hsa04612	0.72499562
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.71883067
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70470021
62	Regulation of autophagy_Homo sapiens_hsa04140	0.63045841
63	Retinol metabolism_Homo sapiens_hsa00830	0.61333677
64	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.59991103
65	Steroid biosynthesis_Homo sapiens_hsa00100	0.59810351
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59006579
67	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.58772849
68	Olfactory transduction_Homo sapiens_hsa04740	0.57752648
69	Glutathione metabolism_Homo sapiens_hsa00480	0.57593279
70	Rheumatoid arthritis_Homo sapiens_hsa05323	0.57492181
71	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.56269585
72	Ether lipid metabolism_Homo sapiens_hsa00565	0.55660656
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55581454
74	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.52442477
75	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.50085209
76	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.49292706
77	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.47780250
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.47054092
79	Folate biosynthesis_Homo sapiens_hsa00790	0.43488258
80	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.42877790
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.41890517
82	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.41111270
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.41089670
84	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.38958037
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.38377585
86	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.37961390
87	Fatty acid degradation_Homo sapiens_hsa00071	0.35706144
88	p53 signaling pathway_Homo sapiens_hsa04115	0.34325348
89	Tyrosine metabolism_Homo sapiens_hsa00350	0.33039690
90	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.32944182
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31430795
92	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.29474995
93	Pyruvate metabolism_Homo sapiens_hsa00620	0.27948680
94	beta-Alanine metabolism_Homo sapiens_hsa00410	0.25121075
95	Non-homologous end-joining_Homo sapiens_hsa03450	0.24936654
96	Nicotine addiction_Homo sapiens_hsa05033	0.22861082
97	Fatty acid elongation_Homo sapiens_hsa00062	0.22752568
98	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.22529698
99	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.21529537
100	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.21490514

RPS18P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »