RPS19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* ribosomal small subunit assembly (GO:0000028)9.07519842
2* viral transcription (GO:0019083)8.87684041
3* translational termination (GO:0006415)8.50700385
4* ribosomal small subunit biogenesis (GO:0042274)7.60007477
5* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.32211230
6* translational elongation (GO:0006414)7.28428619
7* cotranslational protein targeting to membrane (GO:0006613)7.17761605
8* protein targeting to ER (GO:0045047)7.15042076
9* establishment of protein localization to endoplasmic reticulum (GO:0072599)6.80711009
10* protein localization to endoplasmic reticulum (GO:0070972)6.71902861
11* viral life cycle (GO:0019058)6.60680158
12* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.59209231
13* cellular protein complex disassembly (GO:0043624)6.57919506
14* translational initiation (GO:0006413)6.19607058
15* maturation of SSU-rRNA (GO:0030490)6.01416011
16ribosomal large subunit biogenesis (GO:0042273)5.89020715
17chaperone-mediated protein transport (GO:0072321)5.81861027
18* protein complex disassembly (GO:0043241)5.74896324
19* macromolecular complex disassembly (GO:0032984)5.38856508
20establishment of protein localization to mitochondrial membrane (GO:0090151)5.30052901
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.94133541
22respiratory electron transport chain (GO:0022904)4.93007239
23DNA deamination (GO:0045006)4.89137303
24* nuclear-transcribed mRNA catabolic process (GO:0000956)4.84379947
25electron transport chain (GO:0022900)4.82858960
26* protein targeting to membrane (GO:0006612)4.68479098
27* translation (GO:0006412)4.65527415
28* mRNA catabolic process (GO:0006402)4.61319983
29regulation of mitochondrial translation (GO:0070129)4.50150319
30protein complex biogenesis (GO:0070271)4.49210413
31* ribonucleoprotein complex biogenesis (GO:0022613)4.47323001
32* RNA catabolic process (GO:0006401)4.29404538
33mitochondrial respiratory chain complex assembly (GO:0033108)4.26688960
34mitochondrial respiratory chain complex I assembly (GO:0032981)4.25059683
35NADH dehydrogenase complex assembly (GO:0010257)4.25059683
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.25059683
37formation of translation preinitiation complex (GO:0001731)3.87188432
38telomere maintenance via semi-conservative replication (GO:0032201)3.86249276
39protein neddylation (GO:0045116)3.78835984
40pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.72722768
41inner mitochondrial membrane organization (GO:0007007)3.71282751
42DNA strand elongation involved in DNA replication (GO:0006271)3.70579825
43* rRNA processing (GO:0006364)3.65793832
44DNA strand elongation (GO:0022616)3.55931795
45* rRNA metabolic process (GO:0016072)3.52124589
46* cellular component biogenesis (GO:0044085)3.50150462
47ATP biosynthetic process (GO:0006754)3.42511560
48telomere maintenance via recombination (GO:0000722)3.37993962
49purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.35175074
50purine nucleoside triphosphate biosynthetic process (GO:0009145)3.33475166
51deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.32218129
52protein targeting to mitochondrion (GO:0006626)3.28103469
53proteasome assembly (GO:0043248)3.26610792
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.19775206
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.19775206
56establishment of protein localization to mitochondrion (GO:0072655)3.18330854
57* establishment of protein localization to membrane (GO:0090150)3.13332072
58* protein localization to membrane (GO:0072657)3.13004448
59ribonucleoside triphosphate biosynthetic process (GO:0009201)3.10648361
60pyrimidine nucleotide catabolic process (GO:0006244)3.10472662
61pseudouridine synthesis (GO:0001522)3.10141467
62hydrogen ion transmembrane transport (GO:1902600)3.09716555
63exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09294701
64mitotic recombination (GO:0006312)3.08573017
65termination of RNA polymerase III transcription (GO:0006386)3.06446530
66transcription elongation from RNA polymerase III promoter (GO:0006385)3.06446530
67sequestering of actin monomers (GO:0042989)3.05567921
68DNA replication initiation (GO:0006270)3.03396034
69telomere maintenance via telomere lengthening (GO:0010833)3.02142152
70nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98988908
71oxidative phosphorylation (GO:0006119)2.97857820
72protein localization to mitochondrion (GO:0070585)2.97384249
73nucleotide-excision repair, DNA gap filling (GO:0006297)2.95992405
74base-excision repair, AP site formation (GO:0006285)2.95715939
75UTP biosynthetic process (GO:0006228)2.95011482
76cytochrome complex assembly (GO:0017004)2.94929754
77* protein targeting (GO:0006605)2.93278501
78spliceosomal snRNP assembly (GO:0000387)2.92388696
79negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.89907485
80* establishment of protein localization to organelle (GO:0072594)2.89523100
81CENP-A containing nucleosome assembly (GO:0034080)2.88339619
82ribosome biogenesis (GO:0042254)2.85681170
83transcription-coupled nucleotide-excision repair (GO:0006283)2.81841923
84chromatin remodeling at centromere (GO:0031055)2.80852657
85pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.79758147
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.77415818
87intracellular protein transmembrane import (GO:0044743)2.76743954
88establishment of integrated proviral latency (GO:0075713)2.76512589
89deoxyribonucleotide catabolic process (GO:0009264)2.74741000
90DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.74371078
91DNA unwinding involved in DNA replication (GO:0006268)2.74110236
92viral mRNA export from host cell nucleus (GO:0046784)2.73548185
93nucleoside triphosphate biosynthetic process (GO:0009142)2.73394602
94signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.69764134
95intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.69764134
96spliceosomal complex assembly (GO:0000245)2.69320386
97mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.69242836
98respiratory chain complex IV assembly (GO:0008535)2.68790534
99deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.68737689
100pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.68118896
101* protein localization to organelle (GO:0033365)2.67942240
102pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.67375110
103signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.67282575
104signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.67282575
105signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.67282575
106ncRNA 3-end processing (GO:0043628)2.66773539
107histone mRNA metabolic process (GO:0008334)2.66142162
108negative regulation of ligase activity (GO:0051352)2.65446000
109negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.65446000
110rRNA modification (GO:0000154)2.64780587
111regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.64573332
112positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.64495367
113antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.64142116
114response to interferon-beta (GO:0035456)2.64015444
115* ncRNA processing (GO:0034470)2.63824306
116signal transduction involved in DNA damage checkpoint (GO:0072422)2.59976291
117signal transduction involved in DNA integrity checkpoint (GO:0072401)2.59976291
118regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.57858967
119DNA replication checkpoint (GO:0000076)2.57384237
120anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.56468254
121signal transduction involved in cell cycle checkpoint (GO:0072395)2.56283535
122energy coupled proton transport, down electrochemical gradient (GO:0015985)2.54830414
123ATP synthesis coupled proton transport (GO:0015986)2.54830414
124kinetochore organization (GO:0051383)2.53229407
125termination of RNA polymerase I transcription (GO:0006363)2.52836660
126platelet dense granule organization (GO:0060155)2.48420847
127nucleobase biosynthetic process (GO:0046112)2.46529980
1287-methylguanosine mRNA capping (GO:0006370)2.46229281
129DNA replication-independent nucleosome assembly (GO:0006336)2.45873679
130DNA replication-independent nucleosome organization (GO:0034724)2.45873679
131RNA capping (GO:0036260)2.44325738
1327-methylguanosine RNA capping (GO:0009452)2.44325738
133kinetochore assembly (GO:0051382)2.44154156
134transcription elongation from RNA polymerase I promoter (GO:0006362)2.43153109
135GTP biosynthetic process (GO:0006183)2.42383642
136negative regulation of RNA splicing (GO:0033119)2.42372071
137* ncRNA metabolic process (GO:0034660)2.42290662
138* gene expression (GO:0010467)2.39670830
139transcription from RNA polymerase I promoter (GO:0006360)2.39487161
140regulation of cellular amino acid metabolic process (GO:0006521)2.38624224

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.25164530
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.45956583
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.94759575
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83098896
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.37432368
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.33542209
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.15288734
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14881194
9* ETS1_20019798_ChIP-Seq_JURKAT_Human2.97113546
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86947596
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85841811
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.73231555
13* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.68515315
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.66699256
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.66591444
16* XRN2_22483619_ChIP-Seq_HELA_Human2.54749049
17* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53673702
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.52697392
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44972752
20* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.42998244
21* VDR_23849224_ChIP-Seq_CD4+_Human2.42416971
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42354140
23* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.23870312
24* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14669482
25TTF2_22483619_ChIP-Seq_HELA_Human2.14447297
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.13455825
27* FOXP3_21729870_ChIP-Seq_TREG_Human2.13208970
28DCP1A_22483619_ChIP-Seq_HELA_Human2.06264543
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03577660
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00633891
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00124543
32* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98988599
33* ELK1_19687146_ChIP-ChIP_HELA_Human1.92008214
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89553415
35* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.89171433
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.80829375
37* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79743866
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.77491048
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.73096522
40* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69307482
41ERG_20887958_ChIP-Seq_HPC-7_Mouse1.68034954
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.67855014
43* GABP_19822575_ChIP-Seq_HepG2_Human1.66324518
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66208365
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63147148
46IRF8_22096565_ChIP-ChIP_GC-B_Human1.60359488
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.57542829
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.56197565
49CIITA_25753668_ChIP-Seq_RAJI_Human1.52493924
50* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51905898
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50074418
52* SPI1_23547873_ChIP-Seq_NB4_Human1.48041530
53MYC_22102868_ChIP-Seq_BL_Human1.43668564
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40919579
55VDR_21846776_ChIP-Seq_THP-1_Human1.38956174
56SCL_19346495_ChIP-Seq_HPC-7_Human1.38366616
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37441139
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.34916295
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34451940
60* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.31678042
61MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.31306373
62* ELK1_22589737_ChIP-Seq_MCF10A_Human1.30974822
63STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28874615
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28501245
65* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25451053
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24335793
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24246458
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22704168
69* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20839971
70MYC_18940864_ChIP-ChIP_HL60_Human1.20318892
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19525944
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19089146
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16978245
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15890409
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15189610
76SOX2_16153702_ChIP-ChIP_HESCs_Human1.14071171
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13038557
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11869625
79FOXP1_21924763_ChIP-Seq_HESCs_Human1.11695445
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08697432
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08424100
82* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07539922
83EGR1_19374776_ChIP-ChIP_THP-1_Human1.05498620
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.04495768
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.04128081
86KDM5A_27292631_Chip-Seq_BREAST_Human1.01629906
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01492243
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01464139
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01167045
90IRF8_21731497_ChIP-ChIP_J774_Mouse1.01022988
91TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00863791
92* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99814532
93PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99503470
94AR_21909140_ChIP-Seq_LNCAP_Human0.99398434
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99103892
96STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98396195
97POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95515700
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95328118
99* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94821531
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94728400
101* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94031679
102* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92267861
103GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91516320
104MYB_21317192_ChIP-Seq_ERMYB_Mouse0.89755550
105RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89655739
106MAF_26560356_Chip-Seq_TH2_Human0.88944527
107MYB_26560356_Chip-Seq_TH2_Human0.88701417
108RUNX1_22412390_ChIP-Seq_EML_Mouse0.88057509
109* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87866059
110GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87400544
111EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87186042
112MAF_26560356_Chip-Seq_TH1_Human0.86898954
113TET1_21451524_ChIP-Seq_MESCs_Mouse0.86403896
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86274533
115* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85174678
116E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85156726
117ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85064719
118TFEB_21752829_ChIP-Seq_HELA_Human0.84779358
119NANOG_16153702_ChIP-ChIP_HESCs_Human0.84369796
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84094755
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83945653
122YY1_22570637_ChIP-Seq_MALME-3M_Human0.82783321
123IRF1_19129219_ChIP-ChIP_H3396_Human0.82622461
124RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.82009872
125* CTCF_26484167_Chip-Seq_Bcells_Mouse0.80849118
126CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.77933926
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76309456

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.91013923
2MP0010030_abnormal_orbit_morphology3.74330575
3MP0004957_abnormal_blastocyst_morpholog3.07688951
4MP0002396_abnormal_hematopoietic_system3.01241558
5MP0010094_abnormal_chromosome_stability2.89070559
6MP0001293_anophthalmia2.83096553
7MP0001835_abnormal_antigen_presentation2.78091828
8MP0008057_abnormal_DNA_replication2.74320674
9MP0003077_abnormal_cell_cycle2.73039773
10MP0003763_abnormal_thymus_physiology2.53009259
11MP0008789_abnormal_olfactory_epithelium2.51591803
12MP0003111_abnormal_nucleus_morphology2.50759827
13MP0002653_abnormal_ependyma_morphology2.45995694
14MP0008058_abnormal_DNA_repair2.43511735
15MP0008007_abnormal_cellular_replicative2.19931126
16MP0000490_abnormal_crypts_of2.18742091
17MP0000566_synostosis2.18728870
18MP0000685_abnormal_immune_system2.14569564
19MP0005671_abnormal_response_to2.11927524
20MP0009785_altered_susceptibility_to2.08285411
21MP0009333_abnormal_splenocyte_physiolog1.99551123
22MP0005499_abnormal_olfactory_system1.98063603
23MP0005394_taste/olfaction_phenotype1.98063603
24MP0002148_abnormal_hypersensitivity_rea1.95754039
25MP0004808_abnormal_hematopoietic_stem1.94648860
26MP0002132_abnormal_respiratory_system1.92506174
27MP0003786_premature_aging1.86868940
28MP0002398_abnormal_bone_marrow1.85453976
29MP0002166_altered_tumor_susceptibility1.82664486
30MP0001800_abnormal_humoral_immune1.82521924
31MP0000049_abnormal_middle_ear1.82341755
32MP0002234_abnormal_pharynx_morphology1.81947035
33MP0005397_hematopoietic_system_phenotyp1.75256434
34MP0001545_abnormal_hematopoietic_system1.75256434
35MP0005025_abnormal_response_to1.71706522
36MP0005075_abnormal_melanosome_morpholog1.71172551
37MP0002420_abnormal_adaptive_immunity1.71148383
38MP0001853_heart_inflammation1.71059226
39MP0001819_abnormal_immune_cell1.68720423
40MP0002452_abnormal_antigen_presenting1.67528532
41MP0005000_abnormal_immune_tolerance1.66712758
42MP0002722_abnormal_immune_system1.65114623
43MP0003938_abnormal_ear_development1.64421559
44MP0002723_abnormal_immune_serum1.62166326
45MP0002006_tumorigenesis1.61786660
46MP0008932_abnormal_embryonic_tissue1.60954537
47MP0003724_increased_susceptibility_to1.58759398
48MP0000689_abnormal_spleen_morphology1.56978003
49MP0003436_decreased_susceptibility_to1.56564428
50MP0000716_abnormal_immune_system1.55656652
51MP0005377_hearing/vestibular/ear_phenot1.52460945
52MP0003878_abnormal_ear_physiology1.52460945
53MP0000703_abnormal_thymus_morphology1.49870071
54MP0002429_abnormal_blood_cell1.49825524
55MP0001286_abnormal_eye_development1.48458869
56MP0002405_respiratory_system_inflammati1.47909547
57MP0010155_abnormal_intestine_physiology1.47644208
58MP0004142_abnormal_muscle_tone1.46018689
59MP0002697_abnormal_eye_size1.45794210
60MP0003941_abnormal_skin_development1.45423861
61* MP0009379_abnormal_foot_pigmentation1.44245397
62MP0001790_abnormal_immune_system1.41356551
63MP0005387_immune_system_phenotype1.41356551
64MP0000631_abnormal_neuroendocrine_gland1.40311709
65MP0003806_abnormal_nucleotide_metabolis1.39849419
66MP0000465_gastrointestinal_hemorrhage1.39697942
67MP0001346_abnormal_lacrimal_gland1.38304599
68MP0008877_abnormal_DNA_methylation1.38154659
69MP0003123_paternal_imprinting1.37130908
70MP0001529_abnormal_vocalization1.35767451
71MP0002019_abnormal_tumor_incidence1.34898012
72MP0001485_abnormal_pinna_reflex1.34889667
73MP0006054_spinal_hemorrhage1.34641921
74MP0000858_altered_metastatic_potential1.33371084
75MP0001873_stomach_inflammation1.33281956
76MP0003011_delayed_dark_adaptation1.31541355
77MP0002233_abnormal_nose_morphology1.30124882
78MP0004381_abnormal_hair_follicle1.29745892
79MP0006072_abnormal_retinal_apoptosis1.29682858
80MP0003186_abnormal_redox_activity1.24866156
81MP0005464_abnormal_platelet_physiology1.22325545
82MP0009053_abnormal_anal_canal1.21462028
83MP0000313_abnormal_cell_death1.20741687
84MP0003866_abnormal_defecation1.18560051
85MP0000350_abnormal_cell_proliferation1.16800361
86MP0002419_abnormal_innate_immunity1.16153854
87MP0006035_abnormal_mitochondrial_morpho1.15657363
88MP0006292_abnormal_olfactory_placode1.14830241
89MP0003937_abnormal_limbs/digits/tail_de1.13660328
90MP0005084_abnormal_gallbladder_morpholo1.13462299
91MP0002277_abnormal_respiratory_mucosa1.13254581
92MP0002163_abnormal_gland_morphology1.12716394
93MP0003315_abnormal_perineum_morphology1.12711633
94MP0002160_abnormal_reproductive_system1.11417690
95MP0001905_abnormal_dopamine_level1.09130618
96MP0002736_abnormal_nociception_after1.08086395
97MP0002938_white_spotting1.05863345
98MP0004133_heterotaxia1.05250620
99MP0010352_gastrointestinal_tract_polyps1.04074776
100* MP0002095_abnormal_skin_pigmentation1.03341498
101MP0000026_abnormal_inner_ear1.01786125
102MP0000372_irregular_coat_pigmentation1.01738592
103MP0002638_abnormal_pupillary_reflex0.99739099
104MP0003567_abnormal_fetal_cardiomyocyte0.99393945
105MP0008995_early_reproductive_senescence0.97242694
106MP0002092_abnormal_eye_morphology0.95432695
107MP0001845_abnormal_inflammatory_respons0.94149293
108MP0002009_preneoplasia0.93291608
109MP0001145_abnormal_male_reproductive0.93108062
110MP0002249_abnormal_larynx_morphology0.90948914
111MP0005389_reproductive_system_phenotype0.90803518
112MP0001986_abnormal_taste_sensitivity0.90177842
113MP0002111_abnormal_tail_morphology0.89338577
114MP0005195_abnormal_posterior_eye0.89316857
115MP0000653_abnormal_sex_gland0.89216549
116MP0001730_embryonic_growth_arrest0.88099242
117MP0005391_vision/eye_phenotype0.87932918
118MP0003121_genomic_imprinting0.87639199
119MP0003119_abnormal_digestive_system0.85274408
120MP0001929_abnormal_gametogenesis0.84213745
121MP0003755_abnormal_palate_morphology0.82210784
122MP0004742_abnormal_vestibular_system0.79782210
123MP0009250_abnormal_appendicular_skeleto0.79731606
124MP0002085_abnormal_embryonic_tissue0.79473164
125* MP0005174_abnormal_tail_pigmentation0.79450930
126MP0001919_abnormal_reproductive_system0.79349749
127MP0009278_abnormal_bone_marrow0.79269005
128MP0004947_skin_inflammation0.78822045
129MP0002102_abnormal_ear_morphology0.78240011
130MP0000537_abnormal_urethra_morphology0.77827000
131MP0002933_joint_inflammation0.76694346
132MP0003942_abnormal_urinary_system0.76654330
133MP0003283_abnormal_digestive_organ0.75463572
134MP0002282_abnormal_trachea_morphology0.74767183
135MP0005501_abnormal_skin_physiology0.74474382
136MP0000015_abnormal_ear_pigmentation0.74377726
137MP0003718_maternal_effect0.73846472
138MP0003136_yellow_coat_color0.73288608
139MP0002752_abnormal_somatic_nervous0.73164529
140MP0000477_abnormal_intestine_morphology0.71874520
141MP0005645_abnormal_hypothalamus_physiol0.71806259
142MP0005551_abnormal_eye_electrophysiolog0.71788392
143MP0009697_abnormal_copulation0.71759043
144MP0006276_abnormal_autonomic_nervous0.71751185
145* MP0002080_prenatal_lethality0.70697502
146MP0001764_abnormal_homeostasis0.69470140
147MP0001348_abnormal_lacrimal_gland0.68659079
148MP0001697_abnormal_embryo_size0.68562953
149MP0000778_abnormal_nervous_system0.67337357
150MP0003122_maternal_imprinting0.66984949
151MP0001324_abnormal_eye_pigmentation0.66762024
152MP0002751_abnormal_autonomic_nervous0.66553240
153MP0003448_altered_tumor_morphology0.66253428
154MP0008469_abnormal_protein_level0.65432910
155MP0001216_abnormal_epidermal_layer0.64175852
156MP0005409_darkened_coat_color0.62674088
157MP0000470_abnormal_stomach_morphology0.61466518
158MP0001119_abnormal_female_reproductive0.60843956
159MP0001663_abnormal_digestive_system0.60022178
160MP0005023_abnormal_wound_healing0.59526786
161MP0006036_abnormal_mitochondrial_physio0.59014910
162MP0005408_hypopigmentation0.58033385
163MP0002210_abnormal_sex_determination0.57258793
164MP0002060_abnormal_skin_morphology0.57223557

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)8.36937698
2Abnormal number of erythroid precursors (HP:0012131)7.82658212
3* Reticulocytopenia (HP:0001896)6.14220231
4* Macrocytic anemia (HP:0001972)5.00940176
5* Pallor (HP:0000980)4.86361926
6Acute encephalopathy (HP:0006846)4.82774477
7Aplastic anemia (HP:0001915)4.29536880
8Cerebral edema (HP:0002181)3.53532287
9Septo-optic dysplasia (HP:0100842)3.39771143
10Increased hepatocellular lipid droplets (HP:0006565)3.17084428
11IgM deficiency (HP:0002850)3.11018984
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.08469230
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.08469230
14Oral leukoplakia (HP:0002745)3.08290505
15Elevated erythrocyte sedimentation rate (HP:0003565)2.97504796
16Exertional dyspnea (HP:0002875)2.93080473
17* Thrombocytosis (HP:0001894)2.92447516
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.86636200
19Lactic acidosis (HP:0003128)2.74853654
20Rib fusion (HP:0000902)2.72341950
21Mitochondrial inheritance (HP:0001427)2.70532098
22Lipid accumulation in hepatocytes (HP:0006561)2.69873885
23Abnormal hemoglobin (HP:0011902)2.69672180
24Hepatocellular necrosis (HP:0001404)2.66394831
25Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.63914228
26Type I transferrin isoform profile (HP:0003642)2.62812104
273-Methylglutaconic aciduria (HP:0003535)2.62052780
28Petechiae (HP:0000967)2.61278567
29Respiratory failure (HP:0002878)2.56848922
30Optic disc pallor (HP:0000543)2.55384551
31Birth length less than 3rd percentile (HP:0003561)2.52412452
32Respiratory difficulties (HP:0002880)2.49145138
33Leukodystrophy (HP:0002415)2.47948678
34Rough bone trabeculation (HP:0100670)2.47540588
35Asplenia (HP:0001746)2.44605568
36Renal Fanconi syndrome (HP:0001994)2.40701388
37Chronic otitis media (HP:0000389)2.40251138
38Molar tooth sign on MRI (HP:0002419)2.36559750
39Abnormality of midbrain morphology (HP:0002418)2.36559750
40Increased CSF lactate (HP:0002490)2.35658754
41Increased intramyocellular lipid droplets (HP:0012240)2.31983845
42Abnormality of the preputium (HP:0100587)2.31384976
43Hepatic necrosis (HP:0002605)2.30934933
44Poikiloderma (HP:0001029)2.28617106
45Abnormality of renal resorption (HP:0011038)2.28444809
46Congenital, generalized hypertrichosis (HP:0004540)2.28078450
47Anophthalmia (HP:0000528)2.27974294
48Maternal diabetes (HP:0009800)2.27636605
49Pancytopenia (HP:0001876)2.26690445
50Trismus (HP:0000211)2.25971795
51Myositis (HP:0100614)2.25615351
52Acute necrotizing encephalopathy (HP:0006965)2.25036591
53Pancreatic fibrosis (HP:0100732)2.23540409
54Recurrent bronchitis (HP:0002837)2.20843768
55Aplasia/Hypoplasia of the spleen (HP:0010451)2.20651335
56* Depressed nasal ridge (HP:0000457)2.20497309
57Pancreatic cysts (HP:0001737)2.20357693
58Microretrognathia (HP:0000308)2.20075966
59Chromsome breakage (HP:0040012)2.17996912
60Absent septum pellucidum (HP:0001331)2.16985271
61Premature graying of hair (HP:0002216)2.16934467
62Abnormal number of incisors (HP:0011064)2.15458898
63IgG deficiency (HP:0004315)2.14308559
64Cleft eyelid (HP:0000625)2.13893662
65Muscle fiber atrophy (HP:0100295)2.13572037
66Lymphoma (HP:0002665)2.13548405
67Abnormality of the heme biosynthetic pathway (HP:0010472)2.12980999
68Increased serum lactate (HP:0002151)2.12284342
69Sclerocornea (HP:0000647)2.11987612
70Abnormality of T cell physiology (HP:0011840)2.09941080
71Bilateral microphthalmos (HP:0007633)2.08939327
72* Myelodysplasia (HP:0002863)2.08583481
73Hyperglycinemia (HP:0002154)2.07114852
74Abnormal mitochondria in muscle tissue (HP:0008316)2.03863721
75Stenosis of the external auditory canal (HP:0000402)2.03628044
76Multiple enchondromatosis (HP:0005701)2.03292915
77Lethargy (HP:0001254)2.02712807
78Panhypogammaglobulinemia (HP:0003139)2.02564377
79Aplasia/Hypoplasia of the uvula (HP:0010293)1.98915215
80Type 2 muscle fiber atrophy (HP:0003554)1.98867330
81Abnormality of T cells (HP:0002843)1.98658946
82Breast hypoplasia (HP:0003187)1.97230406
83* Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96943406
84Prolonged bleeding time (HP:0003010)1.96847415
85Meckel diverticulum (HP:0002245)1.95567347
86True hermaphroditism (HP:0010459)1.95149241
87Recurrent abscess formation (HP:0002722)1.95062923
88Selective tooth agenesis (HP:0001592)1.94517633
89Pulmonary fibrosis (HP:0002206)1.92815856
90Sparse eyelashes (HP:0000653)1.92339455
91Microvesicular hepatic steatosis (HP:0001414)1.92097019
92Horseshoe kidney (HP:0000085)1.91559859
93Hyperphosphaturia (HP:0003109)1.91210301
94Increased muscle lipid content (HP:0009058)1.91170667
95Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89795802
96Cellular immunodeficiency (HP:0005374)1.89043169
97Reduced antithrombin III activity (HP:0001976)1.88662875
98Abnormality of the ileum (HP:0001549)1.88469195
99Hypoplasia of the pons (HP:0012110)1.87862052
100Bone marrow hypocellularity (HP:0005528)1.87768320
101* Migraine (HP:0002076)1.87436238
102Agammaglobulinemia (HP:0004432)1.86790029
103* Absent thumb (HP:0009777)1.86076497
104Abnormality of urine glucose concentration (HP:0011016)1.83085415
105Glycosuria (HP:0003076)1.83085415
106Abnormality of the septum pellucidum (HP:0007375)1.81945643
107Abnormal trabecular bone morphology (HP:0100671)1.81160638
108Carpal bone hypoplasia (HP:0001498)1.80571817
109Optic nerve coloboma (HP:0000588)1.80194638
110Acute lymphatic leukemia (HP:0006721)1.78476085
111Abnormality of cells of the lymphoid lineage (HP:0012140)1.78392998
112Abnormal protein glycosylation (HP:0012346)1.77844941
113Abnormal glycosylation (HP:0012345)1.77844941
114Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77844941
115Abnormal protein N-linked glycosylation (HP:0012347)1.77844941
116Exercise intolerance (HP:0003546)1.77267567
117Recurrent viral infections (HP:0004429)1.77249436
118Abnormality of the pons (HP:0007361)1.76264474
119Granulocytopenia (HP:0001913)1.76022756
120Amaurosis fugax (HP:0100576)1.75213470
121Progressive macrocephaly (HP:0004481)1.74611328
122* Triphalangeal thumb (HP:0001199)1.74149211
123Neoplasm of the pancreas (HP:0002894)1.74116982
124Pendular nystagmus (HP:0012043)1.73946184
125Abnormality of DNA repair (HP:0003254)1.73779803
126Abnormality of chromosome stability (HP:0003220)1.73377778
127Lymphopenia (HP:0001888)1.73236949
128Patellar aplasia (HP:0006443)1.72974161
129Esophageal atresia (HP:0002032)1.72230984
130* Thick lower lip vermilion (HP:0000179)1.72090657
131Anencephaly (HP:0002323)1.69675747
132Abnormality of B cell number (HP:0010975)1.69619080
133B lymphocytopenia (HP:0010976)1.69619080
134Meningitis (HP:0001287)1.69484867
135Nephronophthisis (HP:0000090)1.68041006
136Holoprosencephaly (HP:0001360)1.67040362
137Concave nail (HP:0001598)1.66399242
138* Abnormality of reticulocytes (HP:0004312)1.65202808
139Tracheoesophageal fistula (HP:0002575)1.63653690
140Myokymia (HP:0002411)1.63400402
141X-linked dominant inheritance (HP:0001423)1.63356373
142Abnormality of the labia minora (HP:0012880)1.62784206
143Emotional lability (HP:0000712)1.61927079
144Optic nerve hypoplasia (HP:0000609)1.61192081
145Nasolacrimal duct obstruction (HP:0000579)1.60748285
146Methylmalonic aciduria (HP:0012120)1.57405645
147Medial flaring of the eyebrow (HP:0010747)1.56583274
148Abnormality of cochlea (HP:0000375)1.56478622
149Absent rod-and cone-mediated responses on ERG (HP:0007688)1.56449432
150Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.55968776
151CNS demyelination (HP:0007305)1.54684838
152Abnormality of the renal collecting system (HP:0004742)1.51945230

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.48880654
2NME24.67657624
3BUB13.18046411
4STK162.96787775
5WEE12.93220769
6SRPK12.61265707
7MAP4K12.35853622
8BCKDK2.33172691
9PIM22.32768330
10EIF2AK12.32411597
11TLK12.29770702
12VRK12.28545333
13TAF12.23243996
14RPS6KB22.19201865
15TGFBR12.11977944
16NUAK11.87768959
17DYRK21.85614425
18CDC71.81565783
19LRRK21.74789559
20PASK1.73557616
21DYRK31.71052272
22TEC1.70521496
23EPHB21.68270128
24ACVR1B1.67301721
25RPS6KA41.60624925
26EIF2AK31.55194494
27TXK1.51339235
28BTK1.51027747
29KIT1.47621725
30MKNK11.43924901
31EEF2K1.41153442
32MST41.37119787
33KDR1.35851790
34BRSK21.35096482
35AURKB1.30828087
36IRAK41.28578423
37CDK71.28391628
38NEK21.27707656
39IKBKB1.26043330
40BLK1.22614493
41ZAP701.21568130
42CDK191.19592820
43FLT31.18548875
44PIM11.16143439
45MAP3K121.15516661
46PLK41.14083987
47IRAK31.10392689
48TYK21.09888128
49TSSK61.07817409
50TESK21.07227962
51ATR1.05666957
52IKBKE1.05470071
53PLK11.03436055
54PLK31.02069258
55MAP2K30.96181043
56JAK30.95487141
57CDK80.94594487
58DAPK30.94106195
59NME10.94067892
60NEK10.93271729
61SYK0.92476987
62TBK10.91259310
63ILK0.90802520
64MAPKAPK30.90172829
65GRK10.88744852
66MAP2K60.87673131
67EIF2AK20.85174723
68MKNK20.82766602
69ABL20.81250183
70STK100.78945419
71PBK0.78741864
72ZAK0.77514576
73MAP3K110.76704552
74MYLK0.74727874
75RPS6KA50.74660763
76MUSK0.74616753
77WNK40.74575356
78LYN0.74092155
79STK40.73578319
80NLK0.73358237
81MAP3K140.71816469
82PAK40.71676384
83MAP3K30.70528640
84TTK0.68557109
85CDK40.68474292
86INSRR0.66292736
87ARAF0.65671245
88CSNK2A20.65642888
89PIK3CA0.65296091
90LCK0.65067809
91CSF1R0.65055664
92CLK10.64620582
93CSNK2A10.64443463
94AURKA0.64394826
95SMG10.64251530
96WNK30.62725798
97BMPR1B0.60972970
98BRAF0.58785731
99CCNB10.57785946
100MAP3K80.57568207
101SCYL20.55919575
102BRSK10.54654385
103MATK0.53202303
104MAP4K20.53130971
105ADRBK20.53012767
106RPS6KA60.52066616
107CHUK0.50549366
108CHEK20.50528982
109TIE10.49892557
110PDK20.48926693
111RPS6KL10.47813765
112RPS6KC10.47813765
113TYRO30.46735525
114MAPK150.46281016
115TESK10.46261726
116TNIK0.45282199
117PRKCI0.45026442
118MAP2K70.44173294
119TGFBR20.43927525
120CDK20.43690789
121PRKG20.42476315
122ATM0.42297032
123ITK0.41924066
124CHEK10.41124865
125EPHA20.40651742
126GRK60.40571701
127CSNK1E0.40202671
128PRKCQ0.39365051
129MAP3K100.38499336
130PRKCG0.37898904
131TAOK30.37489757
132MAPKAPK50.34473515
133ADRBK10.34009176
134EPHA40.30058533
135CSNK1A10.29873147
136MAP2K20.29472741
137CDK10.28804801
138PAK10.26934473
139TRIM280.26758960
140STK240.26735996
141PRKCD0.26661883
142PRKDC0.23266764
143DYRK1B0.21701179
144MARK30.21310275

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030107.08679809
2DNA replication_Homo sapiens_hsa030303.96598950
3Mismatch repair_Homo sapiens_hsa034303.38827940
4Proteasome_Homo sapiens_hsa030503.27993674
5RNA polymerase_Homo sapiens_hsa030203.18617984
6Spliceosome_Homo sapiens_hsa030402.80038545
7Homologous recombination_Homo sapiens_hsa034402.66600497
8Base excision repair_Homo sapiens_hsa034102.50897335
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48930961
10Pyrimidine metabolism_Homo sapiens_hsa002402.39068982
11Nucleotide excision repair_Homo sapiens_hsa034202.37228799
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09316102
13Cardiac muscle contraction_Homo sapiens_hsa042602.06091849
14RNA transport_Homo sapiens_hsa030131.89396277
15Fanconi anemia pathway_Homo sapiens_hsa034601.78743869
16Protein export_Homo sapiens_hsa030601.74179165
17Primary immunodeficiency_Homo sapiens_hsa053401.73071038
18RNA degradation_Homo sapiens_hsa030181.64569194
19Parkinsons disease_Homo sapiens_hsa050121.64515715
20Non-homologous end-joining_Homo sapiens_hsa034501.62379458
21Oxidative phosphorylation_Homo sapiens_hsa001901.62284428
22Cell cycle_Homo sapiens_hsa041101.48631307
23One carbon pool by folate_Homo sapiens_hsa006701.43939871
24Basal transcription factors_Homo sapiens_hsa030221.39713815
25Huntingtons disease_Homo sapiens_hsa050161.34028486
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28055786
27p53 signaling pathway_Homo sapiens_hsa041151.26862805
28Purine metabolism_Homo sapiens_hsa002301.20879113
29Antigen processing and presentation_Homo sapiens_hsa046121.16538382
30Herpes simplex infection_Homo sapiens_hsa051681.12083621
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05044263
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.04446345
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02745821
34Epstein-Barr virus infection_Homo sapiens_hsa051691.01683595
35Alzheimers disease_Homo sapiens_hsa050100.96760280
36Hematopoietic cell lineage_Homo sapiens_hsa046400.95124815
37Systemic lupus erythematosus_Homo sapiens_hsa053220.93946756
38Allograft rejection_Homo sapiens_hsa053300.93525823
39NF-kappa B signaling pathway_Homo sapiens_hsa040640.92633960
40Measles_Homo sapiens_hsa051620.89072318
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88488495
42Basal cell carcinoma_Homo sapiens_hsa052170.84244249
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83811142
44mRNA surveillance pathway_Homo sapiens_hsa030150.81210953
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79446596
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78406113
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77726783
48Sulfur relay system_Homo sapiens_hsa041220.74554691
49Folate biosynthesis_Homo sapiens_hsa007900.73277787
50Legionellosis_Homo sapiens_hsa051340.72264548
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.71599612
52Graft-versus-host disease_Homo sapiens_hsa053320.68498048
53Leishmaniasis_Homo sapiens_hsa051400.67709663
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65883381
55Asthma_Homo sapiens_hsa053100.63413441
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63219142
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62232456
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61747780
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61535724
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.60613807
61Pyruvate metabolism_Homo sapiens_hsa006200.59629772
62Pentose phosphate pathway_Homo sapiens_hsa000300.59362638
63Apoptosis_Homo sapiens_hsa042100.58956864
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.57451215
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57405169
66HTLV-I infection_Homo sapiens_hsa051660.56848027
67Autoimmune thyroid disease_Homo sapiens_hsa053200.54991578
68Glutathione metabolism_Homo sapiens_hsa004800.54910937
69Fatty acid elongation_Homo sapiens_hsa000620.54860648
70Peroxisome_Homo sapiens_hsa041460.54350165
71Viral carcinogenesis_Homo sapiens_hsa052030.54069736
72Arachidonic acid metabolism_Homo sapiens_hsa005900.52832212
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52821165
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52653684
75Hedgehog signaling pathway_Homo sapiens_hsa043400.51938753
76N-Glycan biosynthesis_Homo sapiens_hsa005100.49866537
77Influenza A_Homo sapiens_hsa051640.49774272
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49138109
79Shigellosis_Homo sapiens_hsa051310.45745227
80Biosynthesis of amino acids_Homo sapiens_hsa012300.45646797
81Other glycan degradation_Homo sapiens_hsa005110.45629142
82B cell receptor signaling pathway_Homo sapiens_hsa046620.44981095
83Phototransduction_Homo sapiens_hsa047440.44957894
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44092181
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43222225
86Hepatitis B_Homo sapiens_hsa051610.43187836
87Propanoate metabolism_Homo sapiens_hsa006400.42813725
88Small cell lung cancer_Homo sapiens_hsa052220.42598214
89Vitamin digestion and absorption_Homo sapiens_hsa049770.40549913
90Selenocompound metabolism_Homo sapiens_hsa004500.40262824
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.39762973
92Pertussis_Homo sapiens_hsa051330.37895236
93Linoleic acid metabolism_Homo sapiens_hsa005910.36133789
94Thyroid cancer_Homo sapiens_hsa052160.36040459
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35771620
96Carbon metabolism_Homo sapiens_hsa012000.35464185
97Malaria_Homo sapiens_hsa051440.34992105
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33834126
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33356865
100Acute myeloid leukemia_Homo sapiens_hsa052210.33075850
101T cell receptor signaling pathway_Homo sapiens_hsa046600.32850085
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31519811
103Chemical carcinogenesis_Homo sapiens_hsa052040.29460615
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29221183
105Nitrogen metabolism_Homo sapiens_hsa009100.28588581
106Toxoplasmosis_Homo sapiens_hsa051450.28302927
107Viral myocarditis_Homo sapiens_hsa054160.27325387
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26050640
109Notch signaling pathway_Homo sapiens_hsa043300.25866693
110Osteoclast differentiation_Homo sapiens_hsa043800.25551444
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25523238
112Metabolic pathways_Homo sapiens_hsa011000.25486721
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.24694710
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24325881
115Galactose metabolism_Homo sapiens_hsa000520.24093544
116Tyrosine metabolism_Homo sapiens_hsa003500.22174007
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21878748
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21775271
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.21608788
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21404266
121TNF signaling pathway_Homo sapiens_hsa046680.21157953
122Collecting duct acid secretion_Homo sapiens_hsa049660.21055839
123Platelet activation_Homo sapiens_hsa046110.20592085
124Alcoholism_Homo sapiens_hsa050340.20443776
125Butanoate metabolism_Homo sapiens_hsa006500.20179494
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19243017
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.18997342
128Pathways in cancer_Homo sapiens_hsa052000.18041001
129Retinol metabolism_Homo sapiens_hsa008300.17394440
130Tryptophan metabolism_Homo sapiens_hsa003800.16679953
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16119962
132Fat digestion and absorption_Homo sapiens_hsa049750.15079373
133Wnt signaling pathway_Homo sapiens_hsa043100.14847322
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.13743413
135Hepatitis C_Homo sapiens_hsa051600.13678911
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13504565
137HIF-1 signaling pathway_Homo sapiens_hsa040660.12972620
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.12874222
139Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.12748932
140Caffeine metabolism_Homo sapiens_hsa002320.12175094
141Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.08214309
142Regulation of autophagy_Homo sapiens_hsa041400.07107931
143Hippo signaling pathway_Homo sapiens_hsa043900.05610675

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »