ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	* ribosomal small subunit assembly (GO:0000028)	9.07519842
2	* viral transcription (GO:0019083)	8.87684041
3	* translational termination (GO:0006415)	8.50700385
4	* ribosomal small subunit biogenesis (GO:0042274)	7.60007477
5	* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.32211230
6	* translational elongation (GO:0006414)	7.28428619
7	* cotranslational protein targeting to membrane (GO:0006613)	7.17761605
8	* protein targeting to ER (GO:0045047)	7.15042076
9	* establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.80711009
10	* protein localization to endoplasmic reticulum (GO:0070972)	6.71902861
11	* viral life cycle (GO:0019058)	6.60680158
12	* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.59209231
13	* cellular protein complex disassembly (GO:0043624)	6.57919506
14	* translational initiation (GO:0006413)	6.19607058
15	* maturation of SSU-rRNA (GO:0030490)	6.01416011
16	ribosomal large subunit biogenesis (GO:0042273)	5.89020715
17	chaperone-mediated protein transport (GO:0072321)	5.81861027
18	* protein complex disassembly (GO:0043241)	5.74896324
19	* macromolecular complex disassembly (GO:0032984)	5.38856508
20	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.30052901
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.94133541
22	respiratory electron transport chain (GO:0022904)	4.93007239
23	DNA deamination (GO:0045006)	4.89137303
24	* nuclear-transcribed mRNA catabolic process (GO:0000956)	4.84379947
25	electron transport chain (GO:0022900)	4.82858960
26	* protein targeting to membrane (GO:0006612)	4.68479098
27	* translation (GO:0006412)	4.65527415
28	* mRNA catabolic process (GO:0006402)	4.61319983
29	regulation of mitochondrial translation (GO:0070129)	4.50150319
30	protein complex biogenesis (GO:0070271)	4.49210413
31	* ribonucleoprotein complex biogenesis (GO:0022613)	4.47323001
32	* RNA catabolic process (GO:0006401)	4.29404538
33	mitochondrial respiratory chain complex assembly (GO:0033108)	4.26688960
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.25059683
35	NADH dehydrogenase complex assembly (GO:0010257)	4.25059683
36	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.25059683
37	formation of translation preinitiation complex (GO:0001731)	3.87188432
38	telomere maintenance via semi-conservative replication (GO:0032201)	3.86249276
39	protein neddylation (GO:0045116)	3.78835984
40	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.72722768
41	inner mitochondrial membrane organization (GO:0007007)	3.71282751
42	DNA strand elongation involved in DNA replication (GO:0006271)	3.70579825
43	* rRNA processing (GO:0006364)	3.65793832
44	DNA strand elongation (GO:0022616)	3.55931795
45	* rRNA metabolic process (GO:0016072)	3.52124589
46	* cellular component biogenesis (GO:0044085)	3.50150462
47	ATP biosynthetic process (GO:0006754)	3.42511560
48	telomere maintenance via recombination (GO:0000722)	3.37993962
49	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.35175074
50	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.33475166
51	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.32218129
52	protein targeting to mitochondrion (GO:0006626)	3.28103469
53	proteasome assembly (GO:0043248)	3.26610792
54	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.19775206
55	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.19775206
56	establishment of protein localization to mitochondrion (GO:0072655)	3.18330854
57	* establishment of protein localization to membrane (GO:0090150)	3.13332072
58	* protein localization to membrane (GO:0072657)	3.13004448
59	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.10648361
60	pyrimidine nucleotide catabolic process (GO:0006244)	3.10472662
61	pseudouridine synthesis (GO:0001522)	3.10141467
62	hydrogen ion transmembrane transport (GO:1902600)	3.09716555
63	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.09294701
64	mitotic recombination (GO:0006312)	3.08573017
65	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.06446530
66	termination of RNA polymerase III transcription (GO:0006386)	3.06446530
67	sequestering of actin monomers (GO:0042989)	3.05567921
68	DNA replication initiation (GO:0006270)	3.03396034
69	telomere maintenance via telomere lengthening (GO:0010833)	3.02142152
70	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.98988908
71	oxidative phosphorylation (GO:0006119)	2.97857820
72	protein localization to mitochondrion (GO:0070585)	2.97384249
73	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.95992405
74	base-excision repair, AP site formation (GO:0006285)	2.95715939
75	UTP biosynthetic process (GO:0006228)	2.95011482
76	cytochrome complex assembly (GO:0017004)	2.94929754
77	* protein targeting (GO:0006605)	2.93278501
78	spliceosomal snRNP assembly (GO:0000387)	2.92388696
79	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.89907485
80	* establishment of protein localization to organelle (GO:0072594)	2.89523100
81	CENP-A containing nucleosome assembly (GO:0034080)	2.88339619
82	ribosome biogenesis (GO:0042254)	2.85681170
83	transcription-coupled nucleotide-excision repair (GO:0006283)	2.81841923
84	chromatin remodeling at centromere (GO:0031055)	2.80852657
85	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.79758147
86	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.77415818
87	intracellular protein transmembrane import (GO:0044743)	2.76743954
88	establishment of integrated proviral latency (GO:0075713)	2.76512589
89	deoxyribonucleotide catabolic process (GO:0009264)	2.74741000
90	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.74371078
91	DNA unwinding involved in DNA replication (GO:0006268)	2.74110236
92	viral mRNA export from host cell nucleus (GO:0046784)	2.73548185
93	nucleoside triphosphate biosynthetic process (GO:0009142)	2.73394602
94	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.69764134
95	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.69764134
96	spliceosomal complex assembly (GO:0000245)	2.69320386
97	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.69242836
98	respiratory chain complex IV assembly (GO:0008535)	2.68790534
99	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.68737689
100	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.68118896
101	* protein localization to organelle (GO:0033365)	2.67942240
102	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.67375110
103	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.67282575
104	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.67282575
105	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.67282575
106	ncRNA 3-end processing (GO:0043628)	2.66773539
107	histone mRNA metabolic process (GO:0008334)	2.66142162
108	negative regulation of ligase activity (GO:0051352)	2.65446000
109	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.65446000
110	rRNA modification (GO:0000154)	2.64780587
111	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.64573332
112	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.64495367
113	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.64142116
114	response to interferon-beta (GO:0035456)	2.64015444
115	* ncRNA processing (GO:0034470)	2.63824306
116	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.59976291
117	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.59976291
118	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.57858967
119	DNA replication checkpoint (GO:0000076)	2.57384237
120	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.56468254
121	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.56283535
122	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.54830414
123	ATP synthesis coupled proton transport (GO:0015986)	2.54830414
124	kinetochore organization (GO:0051383)	2.53229407
125	termination of RNA polymerase I transcription (GO:0006363)	2.52836660
126	platelet dense granule organization (GO:0060155)	2.48420847
127	nucleobase biosynthetic process (GO:0046112)	2.46529980
128	7-methylguanosine mRNA capping (GO:0006370)	2.46229281
129	DNA replication-independent nucleosome organization (GO:0034724)	2.45873679
130	DNA replication-independent nucleosome assembly (GO:0006336)	2.45873679
131	7-methylguanosine RNA capping (GO:0009452)	2.44325738
132	RNA capping (GO:0036260)	2.44325738
133	kinetochore assembly (GO:0051382)	2.44154156
134	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.43153109
135	GTP biosynthetic process (GO:0006183)	2.42383642
136	negative regulation of RNA splicing (GO:0033119)	2.42372071
137	* ncRNA metabolic process (GO:0034660)	2.42290662
138	* gene expression (GO:0010467)	2.39670830
139	transcription from RNA polymerase I promoter (GO:0006360)	2.39487161
140	regulation of cellular amino acid metabolic process (GO:0006521)	2.38624224

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	6.25164530
2	* MYC_18555785_ChIP-Seq_MESCs_Mouse	4.45956583
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.94759575
4	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.83098896
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.37432368
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.33542209
7	* MYC_19079543_ChIP-ChIP_MESCs_Mouse	3.15288734
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.14881194
9	* ETS1_20019798_ChIP-Seq_JURKAT_Human	2.97113546
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.86947596
11	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.85841811
12	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.73231555
13	* HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.68515315
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.66699256
15	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.66591444
16	* XRN2_22483619_ChIP-Seq_HELA_Human	2.54749049
17	* CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.53673702
18	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.52697392
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.44972752
20	* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	2.42998244
21	* VDR_23849224_ChIP-Seq_CD4+_Human	2.42416971
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.42354140
23	* TAL1_20887958_ChIP-Seq_HPC-7_Mouse	2.23870312
24	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.14669482
25	TTF2_22483619_ChIP-Seq_HELA_Human	2.14447297
26	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.13455825
27	* FOXP3_21729870_ChIP-Seq_TREG_Human	2.13208970
28	DCP1A_22483619_ChIP-Seq_HELA_Human	2.06264543
29	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.03577660
30	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.00633891
31	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.00124543
32	* FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.98988599
33	* ELK1_19687146_ChIP-ChIP_HELA_Human	1.92008214
34	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.89553415
35	* SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.89171433
36	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.80829375
37	* HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.79743866
38	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.77491048
39	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.73096522
40	* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.69307482
41	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.68034954
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.67855014
43	* GABP_19822575_ChIP-Seq_HepG2_Human	1.66324518
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.66208365
45	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.63147148
46	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.60359488
47	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.57542829
48	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.56197565
49	CIITA_25753668_ChIP-Seq_RAJI_Human	1.52493924
50	* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.51905898
51	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.50074418
52	* SPI1_23547873_ChIP-Seq_NB4_Human	1.48041530
53	MYC_22102868_ChIP-Seq_BL_Human	1.43668564
54	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.40919579
55	VDR_21846776_ChIP-Seq_THP-1_Human	1.38956174
56	SCL_19346495_ChIP-Seq_HPC-7_Human	1.38366616
57	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.37441139
58	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.34916295
59	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.34451940
60	* CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.31678042
61	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.31306373
62	* ELK1_22589737_ChIP-Seq_MCF10A_Human	1.30974822
63	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.28874615
64	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.28501245
65	* ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.25451053
66	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.24335793
67	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.24246458
68	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.22704168
69	* SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.20839971
70	MYC_18940864_ChIP-ChIP_HL60_Human	1.20318892
71	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.19525944
72	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.19089146
73	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.16978245
74	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.15890409
75	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.15189610
76	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.14071171
77	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.13038557
78	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.11869625
79	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.11695445
80	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.08697432
81	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.08424100
82	* CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.07539922
83	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.05498620
84	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.04495768
85	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.04128081
86	KDM5A_27292631_Chip-Seq_BREAST_Human	1.01629906
87	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.01492243
88	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.01464139
89	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.01167045
90	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.01022988
91	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.00863791
92	* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.99814532
93	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.99503470
94	AR_21909140_ChIP-Seq_LNCAP_Human	0.99398434
95	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.99103892
96	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.98396195
97	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.95515700
98	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.95328118
99	* SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.94821531
100	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.94728400
101	* SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.94031679
102	* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.92267861
103	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.91516320
104	MYB_21317192_ChIP-Seq_ERMYB_Mouse	0.89755550
105	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.89655739
106	MAF_26560356_Chip-Seq_TH2_Human	0.88944527
107	MYB_26560356_Chip-Seq_TH2_Human	0.88701417
108	RUNX1_22412390_ChIP-Seq_EML_Mouse	0.88057509
109	* OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.87866059
110	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.87400544
111	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.87186042
112	MAF_26560356_Chip-Seq_TH1_Human	0.86898954
113	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.86403896
114	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.86274533
115	* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.85174678
116	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.85156726
117	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.85064719
118	TFEB_21752829_ChIP-Seq_HELA_Human	0.84779358
119	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.84369796
120	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.84094755
121	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.83945653
122	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.82783321
123	IRF1_19129219_ChIP-ChIP_H3396_Human	0.82622461
124	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.82009872
125	* CTCF_26484167_Chip-Seq_Bcells_Mouse	0.80849118
126	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.77933926
127	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.76309456

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	3.91013923
2	MP0010030_abnormal_orbit_morphology	3.74330575
3	MP0004957_abnormal_blastocyst_morpholog	3.07688951
4	MP0002396_abnormal_hematopoietic_system	3.01241558
5	MP0010094_abnormal_chromosome_stability	2.89070559
6	MP0001293_anophthalmia	2.83096553
7	MP0001835_abnormal_antigen_presentation	2.78091828
8	MP0008057_abnormal_DNA_replication	2.74320674
9	MP0003077_abnormal_cell_cycle	2.73039773
10	MP0003763_abnormal_thymus_physiology	2.53009259
11	MP0008789_abnormal_olfactory_epithelium	2.51591803
12	MP0003111_abnormal_nucleus_morphology	2.50759827
13	MP0002653_abnormal_ependyma_morphology	2.45995694
14	MP0008058_abnormal_DNA_repair	2.43511735
15	MP0008007_abnormal_cellular_replicative	2.19931126
16	MP0000490_abnormal_crypts_of	2.18742091
17	MP0000566_synostosis	2.18728870
18	MP0000685_abnormal_immune_system	2.14569564
19	MP0005671_abnormal_response_to	2.11927524
20	MP0009785_altered_susceptibility_to	2.08285411
21	MP0009333_abnormal_splenocyte_physiolog	1.99551123
22	MP0005499_abnormal_olfactory_system	1.98063603
23	MP0005394_taste/olfaction_phenotype	1.98063603
24	MP0002148_abnormal_hypersensitivity_rea	1.95754039
25	MP0004808_abnormal_hematopoietic_stem	1.94648860
26	MP0002132_abnormal_respiratory_system	1.92506174
27	MP0003786_premature_aging	1.86868940
28	MP0002398_abnormal_bone_marrow	1.85453976
29	MP0002166_altered_tumor_susceptibility	1.82664486
30	MP0001800_abnormal_humoral_immune	1.82521924
31	MP0000049_abnormal_middle_ear	1.82341755
32	MP0002234_abnormal_pharynx_morphology	1.81947035
33	MP0005397_hematopoietic_system_phenotyp	1.75256434
34	MP0001545_abnormal_hematopoietic_system	1.75256434
35	MP0005025_abnormal_response_to	1.71706522
36	MP0005075_abnormal_melanosome_morpholog	1.71172551
37	MP0002420_abnormal_adaptive_immunity	1.71148383
38	MP0001853_heart_inflammation	1.71059226
39	MP0001819_abnormal_immune_cell	1.68720423
40	MP0002452_abnormal_antigen_presenting	1.67528532
41	MP0005000_abnormal_immune_tolerance	1.66712758
42	MP0002722_abnormal_immune_system	1.65114623
43	MP0003938_abnormal_ear_development	1.64421559
44	MP0002723_abnormal_immune_serum	1.62166326
45	MP0002006_tumorigenesis	1.61786660
46	MP0008932_abnormal_embryonic_tissue	1.60954537
47	MP0003724_increased_susceptibility_to	1.58759398
48	MP0000689_abnormal_spleen_morphology	1.56978003
49	MP0003436_decreased_susceptibility_to	1.56564428
50	MP0000716_abnormal_immune_system	1.55656652
51	MP0003878_abnormal_ear_physiology	1.52460945
52	MP0005377_hearing/vestibular/ear_phenot	1.52460945
53	MP0000703_abnormal_thymus_morphology	1.49870071
54	MP0002429_abnormal_blood_cell	1.49825524
55	MP0001286_abnormal_eye_development	1.48458869
56	MP0002405_respiratory_system_inflammati	1.47909547
57	MP0010155_abnormal_intestine_physiology	1.47644208
58	MP0004142_abnormal_muscle_tone	1.46018689
59	MP0002697_abnormal_eye_size	1.45794210
60	MP0003941_abnormal_skin_development	1.45423861
61	* MP0009379_abnormal_foot_pigmentation	1.44245397
62	MP0005387_immune_system_phenotype	1.41356551
63	MP0001790_abnormal_immune_system	1.41356551
64	MP0000631_abnormal_neuroendocrine_gland	1.40311709
65	MP0003806_abnormal_nucleotide_metabolis	1.39849419
66	MP0000465_gastrointestinal_hemorrhage	1.39697942
67	MP0001346_abnormal_lacrimal_gland	1.38304599
68	MP0008877_abnormal_DNA_methylation	1.38154659
69	MP0003123_paternal_imprinting	1.37130908
70	MP0001529_abnormal_vocalization	1.35767451
71	MP0002019_abnormal_tumor_incidence	1.34898012
72	MP0001485_abnormal_pinna_reflex	1.34889667
73	MP0006054_spinal_hemorrhage	1.34641921
74	MP0000858_altered_metastatic_potential	1.33371084
75	MP0001873_stomach_inflammation	1.33281956
76	MP0003011_delayed_dark_adaptation	1.31541355
77	MP0002233_abnormal_nose_morphology	1.30124882
78	MP0004381_abnormal_hair_follicle	1.29745892
79	MP0006072_abnormal_retinal_apoptosis	1.29682858
80	MP0003186_abnormal_redox_activity	1.24866156
81	MP0005464_abnormal_platelet_physiology	1.22325545
82	MP0009053_abnormal_anal_canal	1.21462028
83	MP0000313_abnormal_cell_death	1.20741687
84	MP0003866_abnormal_defecation	1.18560051
85	MP0000350_abnormal_cell_proliferation	1.16800361
86	MP0002419_abnormal_innate_immunity	1.16153854
87	MP0006035_abnormal_mitochondrial_morpho	1.15657363
88	MP0006292_abnormal_olfactory_placode	1.14830241
89	MP0003937_abnormal_limbs/digits/tail_de	1.13660328
90	MP0005084_abnormal_gallbladder_morpholo	1.13462299
91	MP0002277_abnormal_respiratory_mucosa	1.13254581
92	MP0002163_abnormal_gland_morphology	1.12716394
93	MP0003315_abnormal_perineum_morphology	1.12711633
94	MP0002160_abnormal_reproductive_system	1.11417690
95	MP0001905_abnormal_dopamine_level	1.09130618
96	MP0002736_abnormal_nociception_after	1.08086395
97	MP0002938_white_spotting	1.05863345
98	MP0004133_heterotaxia	1.05250620
99	MP0010352_gastrointestinal_tract_polyps	1.04074776
100	* MP0002095_abnormal_skin_pigmentation	1.03341498
101	MP0000026_abnormal_inner_ear	1.01786125
102	MP0000372_irregular_coat_pigmentation	1.01738592
103	MP0002638_abnormal_pupillary_reflex	0.99739099
104	MP0003567_abnormal_fetal_cardiomyocyte	0.99393945
105	MP0008995_early_reproductive_senescence	0.97242694
106	MP0002092_abnormal_eye_morphology	0.95432695
107	MP0001845_abnormal_inflammatory_respons	0.94149293
108	MP0002009_preneoplasia	0.93291608
109	MP0001145_abnormal_male_reproductive	0.93108062
110	MP0002249_abnormal_larynx_morphology	0.90948914
111	MP0005389_reproductive_system_phenotype	0.90803518
112	MP0001986_abnormal_taste_sensitivity	0.90177842
113	MP0002111_abnormal_tail_morphology	0.89338577
114	MP0005195_abnormal_posterior_eye	0.89316857
115	MP0000653_abnormal_sex_gland	0.89216549
116	MP0001730_embryonic_growth_arrest	0.88099242
117	MP0005391_vision/eye_phenotype	0.87932918
118	MP0003121_genomic_imprinting	0.87639199
119	MP0003119_abnormal_digestive_system	0.85274408
120	MP0001929_abnormal_gametogenesis	0.84213745
121	MP0003755_abnormal_palate_morphology	0.82210784
122	MP0004742_abnormal_vestibular_system	0.79782210
123	MP0009250_abnormal_appendicular_skeleto	0.79731606
124	MP0002085_abnormal_embryonic_tissue	0.79473164
125	* MP0005174_abnormal_tail_pigmentation	0.79450930
126	MP0001919_abnormal_reproductive_system	0.79349749
127	MP0009278_abnormal_bone_marrow	0.79269005
128	MP0004947_skin_inflammation	0.78822045
129	MP0002102_abnormal_ear_morphology	0.78240011
130	MP0000537_abnormal_urethra_morphology	0.77827000
131	MP0002933_joint_inflammation	0.76694346
132	MP0003942_abnormal_urinary_system	0.76654330
133	MP0003283_abnormal_digestive_organ	0.75463572
134	MP0002282_abnormal_trachea_morphology	0.74767183
135	MP0005501_abnormal_skin_physiology	0.74474382
136	MP0000015_abnormal_ear_pigmentation	0.74377726
137	MP0003718_maternal_effect	0.73846472
138	MP0003136_yellow_coat_color	0.73288608
139	MP0002752_abnormal_somatic_nervous	0.73164529
140	MP0000477_abnormal_intestine_morphology	0.71874520
141	MP0005645_abnormal_hypothalamus_physiol	0.71806259
142	MP0005551_abnormal_eye_electrophysiolog	0.71788392
143	MP0009697_abnormal_copulation	0.71759043
144	MP0006276_abnormal_autonomic_nervous	0.71751185
145	* MP0002080_prenatal_lethality	0.70697502
146	MP0001764_abnormal_homeostasis	0.69470140
147	MP0001348_abnormal_lacrimal_gland	0.68659079
148	MP0001697_abnormal_embryo_size	0.68562953
149	MP0000778_abnormal_nervous_system	0.67337357
150	MP0003122_maternal_imprinting	0.66984949
151	MP0001324_abnormal_eye_pigmentation	0.66762024
152	MP0002751_abnormal_autonomic_nervous	0.66553240
153	MP0003448_altered_tumor_morphology	0.66253428
154	MP0008469_abnormal_protein_level	0.65432910
155	MP0001216_abnormal_epidermal_layer	0.64175852
156	MP0005409_darkened_coat_color	0.62674088
157	MP0000470_abnormal_stomach_morphology	0.61466518
158	MP0001119_abnormal_female_reproductive	0.60843956
159	MP0001663_abnormal_digestive_system	0.60022178
160	MP0005023_abnormal_wound_healing	0.59526786
161	MP0006036_abnormal_mitochondrial_physio	0.59014910
162	MP0005408_hypopigmentation	0.58033385
163	MP0002210_abnormal_sex_determination	0.57258793
164	MP0002060_abnormal_skin_morphology	0.57223557

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of cells of the erythroid lineage (HP:0012130)	8.36937698
2	Abnormal number of erythroid precursors (HP:0012131)	7.82658212
3	* Reticulocytopenia (HP:0001896)	6.14220231
4	* Macrocytic anemia (HP:0001972)	5.00940176
5	* Pallor (HP:0000980)	4.86361926
6	Acute encephalopathy (HP:0006846)	4.82774477
7	Aplastic anemia (HP:0001915)	4.29536880
8	Cerebral edema (HP:0002181)	3.53532287
9	Septo-optic dysplasia (HP:0100842)	3.39771143
10	Increased hepatocellular lipid droplets (HP:0006565)	3.17084428
11	IgM deficiency (HP:0002850)	3.11018984
12	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.08469230
13	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.08469230
14	Oral leukoplakia (HP:0002745)	3.08290505
15	Elevated erythrocyte sedimentation rate (HP:0003565)	2.97504796
16	Exertional dyspnea (HP:0002875)	2.93080473
17	* Thrombocytosis (HP:0001894)	2.92447516
18	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.86636200
19	Lactic acidosis (HP:0003128)	2.74853654
20	Rib fusion (HP:0000902)	2.72341950
21	Mitochondrial inheritance (HP:0001427)	2.70532098
22	Lipid accumulation in hepatocytes (HP:0006561)	2.69873885
23	Abnormal hemoglobin (HP:0011902)	2.69672180
24	Hepatocellular necrosis (HP:0001404)	2.66394831
25	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.63914228
26	Type I transferrin isoform profile (HP:0003642)	2.62812104
27	3-Methylglutaconic aciduria (HP:0003535)	2.62052780
28	Petechiae (HP:0000967)	2.61278567
29	Respiratory failure (HP:0002878)	2.56848922
30	Optic disc pallor (HP:0000543)	2.55384551
31	Birth length less than 3rd percentile (HP:0003561)	2.52412452
32	Respiratory difficulties (HP:0002880)	2.49145138
33	Leukodystrophy (HP:0002415)	2.47948678
34	Rough bone trabeculation (HP:0100670)	2.47540588
35	Asplenia (HP:0001746)	2.44605568
36	Renal Fanconi syndrome (HP:0001994)	2.40701388
37	Chronic otitis media (HP:0000389)	2.40251138
38	Abnormality of midbrain morphology (HP:0002418)	2.36559750
39	Molar tooth sign on MRI (HP:0002419)	2.36559750
40	Increased CSF lactate (HP:0002490)	2.35658754
41	Increased intramyocellular lipid droplets (HP:0012240)	2.31983845
42	Abnormality of the preputium (HP:0100587)	2.31384976
43	Hepatic necrosis (HP:0002605)	2.30934933
44	Poikiloderma (HP:0001029)	2.28617106
45	Abnormality of renal resorption (HP:0011038)	2.28444809
46	Congenital, generalized hypertrichosis (HP:0004540)	2.28078450
47	Anophthalmia (HP:0000528)	2.27974294
48	Maternal diabetes (HP:0009800)	2.27636605
49	Pancytopenia (HP:0001876)	2.26690445
50	Trismus (HP:0000211)	2.25971795
51	Myositis (HP:0100614)	2.25615351
52	Acute necrotizing encephalopathy (HP:0006965)	2.25036591
53	Pancreatic fibrosis (HP:0100732)	2.23540409
54	Recurrent bronchitis (HP:0002837)	2.20843768
55	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.20651335
56	* Depressed nasal ridge (HP:0000457)	2.20497309
57	Pancreatic cysts (HP:0001737)	2.20357693
58	Microretrognathia (HP:0000308)	2.20075966
59	Chromsome breakage (HP:0040012)	2.17996912
60	Absent septum pellucidum (HP:0001331)	2.16985271
61	Premature graying of hair (HP:0002216)	2.16934467
62	Abnormal number of incisors (HP:0011064)	2.15458898
63	IgG deficiency (HP:0004315)	2.14308559
64	Cleft eyelid (HP:0000625)	2.13893662
65	Muscle fiber atrophy (HP:0100295)	2.13572037
66	Lymphoma (HP:0002665)	2.13548405
67	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.12980999
68	Increased serum lactate (HP:0002151)	2.12284342
69	Sclerocornea (HP:0000647)	2.11987612
70	Abnormality of T cell physiology (HP:0011840)	2.09941080
71	Bilateral microphthalmos (HP:0007633)	2.08939327
72	* Myelodysplasia (HP:0002863)	2.08583481
73	Hyperglycinemia (HP:0002154)	2.07114852
74	Abnormal mitochondria in muscle tissue (HP:0008316)	2.03863721
75	Stenosis of the external auditory canal (HP:0000402)	2.03628044
76	Multiple enchondromatosis (HP:0005701)	2.03292915
77	Lethargy (HP:0001254)	2.02712807
78	Panhypogammaglobulinemia (HP:0003139)	2.02564377
79	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.98915215
80	Type 2 muscle fiber atrophy (HP:0003554)	1.98867330
81	Abnormality of T cells (HP:0002843)	1.98658946
82	Breast hypoplasia (HP:0003187)	1.97230406
83	* Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.96943406
84	Prolonged bleeding time (HP:0003010)	1.96847415
85	Meckel diverticulum (HP:0002245)	1.95567347
86	True hermaphroditism (HP:0010459)	1.95149241
87	Recurrent abscess formation (HP:0002722)	1.95062923
88	Selective tooth agenesis (HP:0001592)	1.94517633
89	Pulmonary fibrosis (HP:0002206)	1.92815856
90	Sparse eyelashes (HP:0000653)	1.92339455
91	Microvesicular hepatic steatosis (HP:0001414)	1.92097019
92	Horseshoe kidney (HP:0000085)	1.91559859
93	Hyperphosphaturia (HP:0003109)	1.91210301
94	Increased muscle lipid content (HP:0009058)	1.91170667
95	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.89795802
96	Cellular immunodeficiency (HP:0005374)	1.89043169
97	Reduced antithrombin III activity (HP:0001976)	1.88662875
98	Abnormality of the ileum (HP:0001549)	1.88469195
99	Hypoplasia of the pons (HP:0012110)	1.87862052
100	Bone marrow hypocellularity (HP:0005528)	1.87768320
101	* Migraine (HP:0002076)	1.87436238
102	Agammaglobulinemia (HP:0004432)	1.86790029
103	* Absent thumb (HP:0009777)	1.86076497
104	Glycosuria (HP:0003076)	1.83085415
105	Abnormality of urine glucose concentration (HP:0011016)	1.83085415
106	Abnormality of the septum pellucidum (HP:0007375)	1.81945643
107	Abnormal trabecular bone morphology (HP:0100671)	1.81160638
108	Carpal bone hypoplasia (HP:0001498)	1.80571817
109	Optic nerve coloboma (HP:0000588)	1.80194638
110	Acute lymphatic leukemia (HP:0006721)	1.78476085
111	Abnormality of cells of the lymphoid lineage (HP:0012140)	1.78392998
112	Abnormal protein N-linked glycosylation (HP:0012347)	1.77844941
113	Abnormal protein glycosylation (HP:0012346)	1.77844941
114	Abnormal glycosylation (HP:0012345)	1.77844941
115	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.77844941
116	Exercise intolerance (HP:0003546)	1.77267567
117	Recurrent viral infections (HP:0004429)	1.77249436
118	Abnormality of the pons (HP:0007361)	1.76264474
119	Granulocytopenia (HP:0001913)	1.76022756
120	Amaurosis fugax (HP:0100576)	1.75213470
121	Progressive macrocephaly (HP:0004481)	1.74611328
122	* Triphalangeal thumb (HP:0001199)	1.74149211
123	Neoplasm of the pancreas (HP:0002894)	1.74116982
124	Pendular nystagmus (HP:0012043)	1.73946184
125	Abnormality of DNA repair (HP:0003254)	1.73779803
126	Abnormality of chromosome stability (HP:0003220)	1.73377778
127	Lymphopenia (HP:0001888)	1.73236949
128	Patellar aplasia (HP:0006443)	1.72974161
129	Esophageal atresia (HP:0002032)	1.72230984
130	* Thick lower lip vermilion (HP:0000179)	1.72090657
131	Anencephaly (HP:0002323)	1.69675747
132	B lymphocytopenia (HP:0010976)	1.69619080
133	Abnormality of B cell number (HP:0010975)	1.69619080
134	Meningitis (HP:0001287)	1.69484867
135	Nephronophthisis (HP:0000090)	1.68041006
136	Holoprosencephaly (HP:0001360)	1.67040362
137	Concave nail (HP:0001598)	1.66399242
138	* Abnormality of reticulocytes (HP:0004312)	1.65202808
139	Tracheoesophageal fistula (HP:0002575)	1.63653690
140	Myokymia (HP:0002411)	1.63400402
141	X-linked dominant inheritance (HP:0001423)	1.63356373
142	Abnormality of the labia minora (HP:0012880)	1.62784206
143	Emotional lability (HP:0000712)	1.61927079
144	Optic nerve hypoplasia (HP:0000609)	1.61192081
145	Nasolacrimal duct obstruction (HP:0000579)	1.60748285
146	Methylmalonic aciduria (HP:0012120)	1.57405645
147	Medial flaring of the eyebrow (HP:0010747)	1.56583274
148	Abnormality of cochlea (HP:0000375)	1.56478622
149	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.56449432
150	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.55968776
151	CNS demyelination (HP:0007305)	1.54684838
152	Abnormality of the renal collecting system (HP:0004742)	1.51945230

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	6.48880654
2	NME2	4.67657624
3	BUB1	3.18046411
4	STK16	2.96787775
5	WEE1	2.93220769
6	SRPK1	2.61265707
7	MAP4K1	2.35853622
8	BCKDK	2.33172691
9	PIM2	2.32768330
10	EIF2AK1	2.32411597
11	TLK1	2.29770702
12	VRK1	2.28545333
13	TAF1	2.23243996
14	RPS6KB2	2.19201865
15	TGFBR1	2.11977944
16	NUAK1	1.87768959
17	DYRK2	1.85614425
18	CDC7	1.81565783
19	LRRK2	1.74789559
20	PASK	1.73557616
21	DYRK3	1.71052272
22	TEC	1.70521496
23	EPHB2	1.68270128
24	ACVR1B	1.67301721
25	RPS6KA4	1.60624925
26	EIF2AK3	1.55194494
27	TXK	1.51339235
28	BTK	1.51027747
29	KIT	1.47621725
30	MKNK1	1.43924901
31	EEF2K	1.41153442
32	MST4	1.37119787
33	KDR	1.35851790
34	BRSK2	1.35096482
35	AURKB	1.30828087
36	IRAK4	1.28578423
37	CDK7	1.28391628
38	NEK2	1.27707656
39	IKBKB	1.26043330
40	BLK	1.22614493
41	ZAP70	1.21568130
42	CDK19	1.19592820
43	FLT3	1.18548875
44	PIM1	1.16143439
45	MAP3K12	1.15516661
46	PLK4	1.14083987
47	IRAK3	1.10392689
48	TYK2	1.09888128
49	TSSK6	1.07817409
50	TESK2	1.07227962
51	ATR	1.05666957
52	IKBKE	1.05470071
53	PLK1	1.03436055
54	PLK3	1.02069258
55	MAP2K3	0.96181043
56	JAK3	0.95487141
57	CDK8	0.94594487
58	DAPK3	0.94106195
59	NME1	0.94067892
60	NEK1	0.93271729
61	SYK	0.92476987
62	TBK1	0.91259310
63	ILK	0.90802520
64	MAPKAPK3	0.90172829
65	GRK1	0.88744852
66	MAP2K6	0.87673131
67	EIF2AK2	0.85174723
68	MKNK2	0.82766602
69	ABL2	0.81250183
70	STK10	0.78945419
71	PBK	0.78741864
72	ZAK	0.77514576
73	MAP3K11	0.76704552
74	MYLK	0.74727874
75	RPS6KA5	0.74660763
76	MUSK	0.74616753
77	WNK4	0.74575356
78	LYN	0.74092155
79	STK4	0.73578319
80	NLK	0.73358237
81	MAP3K14	0.71816469
82	PAK4	0.71676384
83	MAP3K3	0.70528640
84	TTK	0.68557109
85	CDK4	0.68474292
86	INSRR	0.66292736
87	ARAF	0.65671245
88	CSNK2A2	0.65642888
89	PIK3CA	0.65296091
90	LCK	0.65067809
91	CSF1R	0.65055664
92	CLK1	0.64620582
93	CSNK2A1	0.64443463
94	AURKA	0.64394826
95	SMG1	0.64251530
96	WNK3	0.62725798
97	BMPR1B	0.60972970
98	BRAF	0.58785731
99	CCNB1	0.57785946
100	MAP3K8	0.57568207
101	SCYL2	0.55919575
102	BRSK1	0.54654385
103	MATK	0.53202303
104	MAP4K2	0.53130971
105	ADRBK2	0.53012767
106	RPS6KA6	0.52066616
107	CHUK	0.50549366
108	CHEK2	0.50528982
109	TIE1	0.49892557
110	PDK2	0.48926693
111	RPS6KC1	0.47813765
112	RPS6KL1	0.47813765
113	TYRO3	0.46735525
114	MAPK15	0.46281016
115	TESK1	0.46261726
116	TNIK	0.45282199
117	PRKCI	0.45026442
118	MAP2K7	0.44173294
119	TGFBR2	0.43927525
120	CDK2	0.43690789
121	PRKG2	0.42476315
122	ATM	0.42297032
123	ITK	0.41924066
124	CHEK1	0.41124865
125	EPHA2	0.40651742
126	GRK6	0.40571701
127	CSNK1E	0.40202671
128	PRKCQ	0.39365051
129	MAP3K10	0.38499336
130	PRKCG	0.37898904
131	TAOK3	0.37489757
132	MAPKAPK5	0.34473515
133	ADRBK1	0.34009176
134	EPHA4	0.30058533
135	CSNK1A1	0.29873147
136	MAP2K2	0.29472741
137	CDK1	0.28804801
138	PAK1	0.26934473
139	TRIM28	0.26758960
140	STK24	0.26735996
141	PRKCD	0.26661883
142	PRKDC	0.23266764
143	DYRK1B	0.21701179
144	MARK3	0.21310275

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	* Ribosome_Homo sapiens_hsa03010	7.08679809
2	DNA replication_Homo sapiens_hsa03030	3.96598950
3	Mismatch repair_Homo sapiens_hsa03430	3.38827940
4	Proteasome_Homo sapiens_hsa03050	3.27993674
5	RNA polymerase_Homo sapiens_hsa03020	3.18617984
6	Spliceosome_Homo sapiens_hsa03040	2.80038545
7	Homologous recombination_Homo sapiens_hsa03440	2.66600497
8	Base excision repair_Homo sapiens_hsa03410	2.50897335
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.48930961
10	Pyrimidine metabolism_Homo sapiens_hsa00240	2.39068982
11	Nucleotide excision repair_Homo sapiens_hsa03420	2.37228799
12	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.09316102
13	Cardiac muscle contraction_Homo sapiens_hsa04260	2.06091849
14	RNA transport_Homo sapiens_hsa03013	1.89396277
15	Fanconi anemia pathway_Homo sapiens_hsa03460	1.78743869
16	Protein export_Homo sapiens_hsa03060	1.74179165
17	Primary immunodeficiency_Homo sapiens_hsa05340	1.73071038
18	RNA degradation_Homo sapiens_hsa03018	1.64569194
19	Parkinsons disease_Homo sapiens_hsa05012	1.64515715
20	Non-homologous end-joining_Homo sapiens_hsa03450	1.62379458
21	Oxidative phosphorylation_Homo sapiens_hsa00190	1.62284428
22	Cell cycle_Homo sapiens_hsa04110	1.48631307
23	One carbon pool by folate_Homo sapiens_hsa00670	1.43939871
24	Basal transcription factors_Homo sapiens_hsa03022	1.39713815
25	Huntingtons disease_Homo sapiens_hsa05016	1.34028486
26	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.28055786
27	p53 signaling pathway_Homo sapiens_hsa04115	1.26862805
28	Purine metabolism_Homo sapiens_hsa00230	1.20879113
29	Antigen processing and presentation_Homo sapiens_hsa04612	1.16538382
30	Herpes simplex infection_Homo sapiens_hsa05168	1.12083621
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.05044263
32	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.04446345
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.02745821
34	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.01683595
35	Alzheimers disease_Homo sapiens_hsa05010	0.96760280
36	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.95124815
37	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.93946756
38	Allograft rejection_Homo sapiens_hsa05330	0.93525823
39	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.92633960
40	Measles_Homo sapiens_hsa05162	0.89072318
41	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.88488495
42	Basal cell carcinoma_Homo sapiens_hsa05217	0.84244249
43	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.83811142
44	mRNA surveillance pathway_Homo sapiens_hsa03015	0.81210953
45	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.79446596
46	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.78406113
47	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.77726783
48	Sulfur relay system_Homo sapiens_hsa04122	0.74554691
49	Folate biosynthesis_Homo sapiens_hsa00790	0.73277787
50	Legionellosis_Homo sapiens_hsa05134	0.72264548
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.71599612
52	Graft-versus-host disease_Homo sapiens_hsa05332	0.68498048
53	Leishmaniasis_Homo sapiens_hsa05140	0.67709663
54	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.65883381
55	Asthma_Homo sapiens_hsa05310	0.63413441
56	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.63219142
57	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.62232456
58	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.61747780
59	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61535724
60	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.60613807
61	Pyruvate metabolism_Homo sapiens_hsa00620	0.59629772
62	Pentose phosphate pathway_Homo sapiens_hsa00030	0.59362638
63	Apoptosis_Homo sapiens_hsa04210	0.58956864
64	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.57451215
65	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.57405169
66	HTLV-I infection_Homo sapiens_hsa05166	0.56848027
67	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.54991578
68	Glutathione metabolism_Homo sapiens_hsa00480	0.54910937
69	Fatty acid elongation_Homo sapiens_hsa00062	0.54860648
70	Peroxisome_Homo sapiens_hsa04146	0.54350165
71	Viral carcinogenesis_Homo sapiens_hsa05203	0.54069736
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.52832212
73	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.52821165
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.52653684
75	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.51938753
76	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.49866537
77	Influenza A_Homo sapiens_hsa05164	0.49774272
78	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.49138109
79	Shigellosis_Homo sapiens_hsa05131	0.45745227
80	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.45646797
81	Other glycan degradation_Homo sapiens_hsa00511	0.45629142
82	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.44981095
83	Phototransduction_Homo sapiens_hsa04744	0.44957894
84	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.44092181
85	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.43222225
86	Hepatitis B_Homo sapiens_hsa05161	0.43187836
87	Propanoate metabolism_Homo sapiens_hsa00640	0.42813725
88	Small cell lung cancer_Homo sapiens_hsa05222	0.42598214
89	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.40549913
90	Selenocompound metabolism_Homo sapiens_hsa00450	0.40262824
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.39762973
92	Pertussis_Homo sapiens_hsa05133	0.37895236
93	Linoleic acid metabolism_Homo sapiens_hsa00591	0.36133789
94	Thyroid cancer_Homo sapiens_hsa05216	0.36040459
95	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.35771620
96	Carbon metabolism_Homo sapiens_hsa01200	0.35464185
97	Malaria_Homo sapiens_hsa05144	0.34992105
98	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.33834126
99	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.33356865
100	Acute myeloid leukemia_Homo sapiens_hsa05221	0.33075850
101	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.32850085
102	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31519811
103	Chemical carcinogenesis_Homo sapiens_hsa05204	0.29460615
104	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.29221183
105	Nitrogen metabolism_Homo sapiens_hsa00910	0.28588581
106	Toxoplasmosis_Homo sapiens_hsa05145	0.28302927
107	Viral myocarditis_Homo sapiens_hsa05416	0.27325387
108	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.26050640
109	Notch signaling pathway_Homo sapiens_hsa04330	0.25866693
110	Osteoclast differentiation_Homo sapiens_hsa04380	0.25551444
111	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.25523238
112	Metabolic pathways_Homo sapiens_hsa01100	0.25486721
113	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.24694710
114	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.24325881
115	Galactose metabolism_Homo sapiens_hsa00052	0.24093544
116	Tyrosine metabolism_Homo sapiens_hsa00350	0.22174007
117	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.21878748
118	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.21775271
119	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.21608788
120	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.21404266
121	TNF signaling pathway_Homo sapiens_hsa04668	0.21157953
122	Collecting duct acid secretion_Homo sapiens_hsa04966	0.21055839
123	Platelet activation_Homo sapiens_hsa04611	0.20592085
124	Alcoholism_Homo sapiens_hsa05034	0.20443776
125	Butanoate metabolism_Homo sapiens_hsa00650	0.20179494
126	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.19243017
127	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.18997342
128	Pathways in cancer_Homo sapiens_hsa05200	0.18041001
129	Retinol metabolism_Homo sapiens_hsa00830	0.17394440
130	Tryptophan metabolism_Homo sapiens_hsa00380	0.16679953
131	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.16119962
132	Fat digestion and absorption_Homo sapiens_hsa04975	0.15079373
133	Wnt signaling pathway_Homo sapiens_hsa04310	0.14847322
134	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.13743413
135	Hepatitis C_Homo sapiens_hsa05160	0.13678911
136	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.13504565
137	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.12972620
138	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.12874222
139	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.12748932
140	Caffeine metabolism_Homo sapiens_hsa00232	0.12175094
141	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.08214309
142	Regulation of autophagy_Homo sapiens_hsa04140	0.07107931
143	Hippo signaling pathway_Homo sapiens_hsa04390	0.05610675

RPS19

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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