

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * viral transcription (GO:0019083) | 9.41825592 |
| 2 | * translational termination (GO:0006415) | 9.06612302 |
| 3 | ribosomal small subunit biogenesis (GO:0042274) | 8.48604897 |
| 4 | ribosomal small subunit assembly (GO:0000028) | 8.42630001 |
| 5 | * translational elongation (GO:0006414) | 7.67483655 |
| 6 | * SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 7.60220210 |
| 7 | * protein targeting to ER (GO:0045047) | 7.45750137 |
| 8 | * cotranslational protein targeting to membrane (GO:0006613) | 7.45344586 |
| 9 | * establishment of protein localization to endoplasmic reticulum (GO:0072599) | 7.12907216 |
| 10 | * nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 7.11588405 |
| 11 | * cellular protein complex disassembly (GO:0043624) | 7.01964127 |
| 12 | * viral life cycle (GO:0019058) | 7.00098683 |
| 13 | maturation of SSU-rRNA (GO:0030490) | 6.95461229 |
| 14 | * protein localization to endoplasmic reticulum (GO:0070972) | 6.94413645 |
| 15 | * translational initiation (GO:0006413) | 6.70810892 |
| 16 | ribosomal large subunit biogenesis (GO:0042273) | 6.40700775 |
| 17 | * protein complex disassembly (GO:0043241) | 6.14722617 |
| 18 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.01283216 |
| 19 | * macromolecular complex disassembly (GO:0032984) | 5.74150094 |
| 20 | ATP synthesis coupled proton transport (GO:0015986) | 5.49782190 |
| 21 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.49782190 |
| 22 | * nuclear-transcribed mRNA catabolic process (GO:0000956) | 5.06243072 |
| 23 | * protein targeting to membrane (GO:0006612) | 4.97262389 |
| 24 | * mRNA catabolic process (GO:0006402) | 4.81054224 |
| 25 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.79318885 |
| 26 | * translation (GO:0006412) | 4.62195334 |
| 27 | * RNA catabolic process (GO:0006401) | 4.51871521 |
| 28 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.13353016 |
| 29 | formation of translation preinitiation complex (GO:0001731) | 3.88665669 |
| 30 | rRNA processing (GO:0006364) | 3.76667194 |
| 31 | respiratory electron transport chain (GO:0022904) | 3.75820368 |
| 32 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.67700384 |
| 33 | chaperone-mediated protein transport (GO:0072321) | 3.66127487 |
| 34 | electron transport chain (GO:0022900) | 3.64664474 |
| 35 | rRNA metabolic process (GO:0016072) | 3.62825569 |
| 36 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.58573486 |
| 37 | DNA strand elongation (GO:0022616) | 3.47780060 |
| 38 | cellular component biogenesis (GO:0044085) | 3.40987786 |
| 39 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.37880590 |
| 40 | DNA unwinding involved in DNA replication (GO:0006268) | 3.37020801 |
| 41 | ncRNA 3-end processing (GO:0043628) | 3.32418572 |
| 42 | protein localization to kinetochore (GO:0034501) | 3.32225880 |
| 43 | DNA replication initiation (GO:0006270) | 3.29290762 |
| 44 | * establishment of protein localization to membrane (GO:0090150) | 3.28484907 |
| 45 | DNA deamination (GO:0045006) | 3.24227813 |
| 46 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.23472140 |
| 47 | negative regulation of RNA splicing (GO:0033119) | 3.19151444 |
| 48 | telomere maintenance via recombination (GO:0000722) | 3.14290248 |
| 49 | * establishment of protein localization to organelle (GO:0072594) | 3.05844845 |
| 50 | mitotic recombination (GO:0006312) | 3.02045833 |
| 51 | spliceosomal snRNP assembly (GO:0000387) | 3.00409723 |
| 52 | * protein targeting (GO:0006605) | 2.99296292 |
| 53 | chromatin remodeling at centromere (GO:0031055) | 2.98352612 |
| 54 | CENP-A containing nucleosome assembly (GO:0034080) | 2.97299744 |
| 55 | protein localization to chromosome, centromeric region (GO:0071459) | 2.96086817 |
| 56 | kinetochore organization (GO:0051383) | 2.93814197 |
| 57 | telomere maintenance via telomere lengthening (GO:0010833) | 2.93165553 |
| 58 | oxidative phosphorylation (GO:0006119) | 2.92727039 |
| 59 | inner mitochondrial membrane organization (GO:0007007) | 2.91375969 |
| 60 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.90540263 |
| 61 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.90540263 |
| 62 | DNA replication checkpoint (GO:0000076) | 2.87120430 |
| 63 | mitotic nuclear envelope disassembly (GO:0007077) | 2.83063492 |
| 64 | ribosome biogenesis (GO:0042254) | 2.82729238 |
| 65 | spliceosomal complex assembly (GO:0000245) | 2.81355836 |
| 66 | mitotic chromosome condensation (GO:0007076) | 2.75585683 |
| 67 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.73953162 |
| 68 | ATP biosynthetic process (GO:0006754) | 2.73744901 |
| 69 | DNA replication-independent nucleosome organization (GO:0034724) | 2.72061638 |
| 70 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.72061638 |
| 71 | * cellular component disassembly (GO:0022411) | 2.68271253 |
| 72 | myeloid cell homeostasis (GO:0002262) | 2.64341694 |
| 73 | mitotic metaphase plate congression (GO:0007080) | 2.63282457 |
| 74 | membrane disassembly (GO:0030397) | 2.60002995 |
| 75 | nuclear envelope disassembly (GO:0051081) | 2.60002995 |
| 76 | negative regulation of DNA repair (GO:0045738) | 2.59668883 |
| 77 | kinetochore assembly (GO:0051382) | 2.59201385 |
| 78 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 2.58767972 |
| 79 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.57915950 |
| 80 | ribosome assembly (GO:0042255) | 2.56598338 |
| 81 | IMP biosynthetic process (GO:0006188) | 2.56460671 |
| 82 | ncRNA processing (GO:0034470) | 2.55796540 |
| 83 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.55642297 |
| 84 | * gene expression (GO:0010467) | 2.55281691 |
| 85 | DNA topological change (GO:0006265) | 2.55264950 |
| 86 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 2.54051129 |
| 87 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.53376048 |
| 88 | termination of RNA polymerase III transcription (GO:0006386) | 2.53376048 |
| 89 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.52643325 |
| 90 | RNA splicing, via transesterification reactions (GO:0000375) | 2.52438571 |
| 91 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 2.51919866 |
| 92 | mRNA splicing, via spliceosome (GO:0000398) | 2.51919866 |
| 93 | establishment of integrated proviral latency (GO:0075713) | 2.51902012 |
| 94 | pseudouridine synthesis (GO:0001522) | 2.51751851 |
| 95 | nucleobase biosynthetic process (GO:0046112) | 2.50327267 |
| 96 | regulation of mitochondrial translation (GO:0070129) | 2.49761545 |
| 97 | termination of RNA polymerase II transcription (GO:0006369) | 2.49609730 |
| 98 | heterochromatin organization (GO:0070828) | 2.46229211 |
| 99 | nuclear pore organization (GO:0006999) | 2.45147563 |
| 100 | regulation of protein heterodimerization activity (GO:0043497) | 2.44860490 |
| 101 | regulation of translational fidelity (GO:0006450) | 2.44715400 |
| 102 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.44515071 |
| 103 | aerobic respiration (GO:0009060) | 2.44248395 |
| 104 | * protein localization to membrane (GO:0072657) | 2.42822520 |
| 105 | ribonucleoprotein complex assembly (GO:0022618) | 2.41250740 |
| 106 | regulation of mitotic spindle organization (GO:0060236) | 2.40258340 |
| 107 | regulation of spindle organization (GO:0090224) | 2.39573350 |
| 108 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.38179179 |
| 109 | histone mRNA metabolic process (GO:0008334) | 2.37944703 |
| 110 | mitotic sister chromatid segregation (GO:0000070) | 2.37166028 |
| 111 | metaphase plate congression (GO:0051310) | 2.36873186 |
| 112 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.35646842 |
| 113 | nuclear pore complex assembly (GO:0051292) | 2.34515762 |
| 114 | histone exchange (GO:0043486) | 2.34141850 |
| 115 | innate immune response in mucosa (GO:0002227) | 2.33949118 |
| 116 | negative regulation of mRNA processing (GO:0050686) | 2.33494220 |
| 117 | ncRNA metabolic process (GO:0034660) | 2.33386032 |
| 118 | IMP metabolic process (GO:0046040) | 2.33066159 |
| 119 | protein targeting to mitochondrion (GO:0006626) | 2.32123747 |
| 120 | mitotic nuclear envelope reassembly (GO:0007084) | 2.31976469 |
| 121 | nuclear envelope reassembly (GO:0031468) | 2.31976469 |
| 122 | * protein localization to organelle (GO:0033365) | 2.31958019 |
| 123 | chromatin assembly or disassembly (GO:0006333) | 2.31418207 |
| 124 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.31201561 |
| 125 | NADH dehydrogenase complex assembly (GO:0010257) | 2.31201561 |
| 126 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.31201561 |
| 127 | * single-organism cellular localization (GO:1902580) | 2.31146448 |
| 128 | DNA-templated transcription, termination (GO:0006353) | 2.29797896 |
| 129 | ribonucleoprotein complex subunit organization (GO:0071826) | 2.27717440 |
| 130 | establishment of viral latency (GO:0019043) | 2.27505227 |
| 131 | pyrimidine nucleotide catabolic process (GO:0006244) | 2.26581295 |
| 132 | protein complex biogenesis (GO:0070271) | 2.25744841 |
| 133 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.25596306 |
| 134 | establishment of protein localization to mitochondrion (GO:0072655) | 2.23882097 |
| 135 | viral protein processing (GO:0019082) | 2.22538086 |
| 136 | UTP biosynthetic process (GO:0006228) | 2.21441431 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.98731706 |
| 2 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.66763263 |
| 3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.72401116 |
| 4 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.66724634 |
| 5 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.52189489 |
| 6 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.27723220 |
| 7 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.25055294 |
| 8 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.96117496 |
| 9 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.77937422 |
| 10 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.72243320 |
| 11 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.71032617 |
| 12 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.66055482 |
| 13 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.61838241 |
| 14 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.61207621 |
| 15 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.45213556 |
| 16 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.39302785 |
| 17 | * CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.38199451 |
| 18 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.34583534 |
| 19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.27078706 |
| 20 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.20610502 |
| 21 | * NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.15794960 |
| 22 | * TTF2_22483619_ChIP-Seq_HELA_Human | 2.14606125 |
| 23 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.13697928 |
| 24 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.11479558 |
| 25 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.00477825 |
| 26 | * DCP1A_22483619_ChIP-Seq_HELA_Human | 1.98924621 |
| 27 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.98845861 |
| 28 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.95992407 |
| 29 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.95259025 |
| 30 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.88892007 |
| 31 | MYC_22102868_ChIP-Seq_BL_Human | 1.88045715 |
| 32 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.87401447 |
| 33 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 1.87151406 |
| 34 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 1.79937028 |
| 35 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.78476693 |
| 36 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.60650248 |
| 37 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.59534169 |
| 38 | * E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.59044407 |
| 39 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.57601366 |
| 40 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.56651971 |
| 41 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.55646910 |
| 42 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.55470177 |
| 43 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.52284207 |
| 44 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.51574909 |
| 45 | * GABP_19822575_ChIP-Seq_HepG2_Human | 1.48621228 |
| 46 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.47636884 |
| 47 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.46175535 |
| 48 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.43228488 |
| 49 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.43078643 |
| 50 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.43064963 |
| 51 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.41623180 |
| 52 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.40354444 |
| 53 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.39785589 |
| 54 | * KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.39620626 |
| 55 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.37178230 |
| 56 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.36402926 |
| 57 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.35512819 |
| 58 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.33992060 |
| 59 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.33484801 |
| 60 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.32436324 |
| 61 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.31528916 |
| 62 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.31321748 |
| 63 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.31075425 |
| 64 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.31025811 |
| 65 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.25748958 |
| 66 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.24850795 |
| 67 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.24418413 |
| 68 | * THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.23930463 |
| 69 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.19573385 |
| 70 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.19573385 |
| 71 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.19573385 |
| 72 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.17122386 |
| 73 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.16788553 |
| 74 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.15530100 |
| 75 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.14145143 |
| 76 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.13342128 |
| 77 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.13064419 |
| 78 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.12674432 |
| 79 | * POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.12654982 |
| 80 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.12095132 |
| 81 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.10192602 |
| 82 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.09538645 |
| 83 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.08890795 |
| 84 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.08658485 |
| 85 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.07768686 |
| 86 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.06411099 |
| 87 | * CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.05261017 |
| 88 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.05238404 |
| 89 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.04072703 |
| 90 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.02764405 |
| 91 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.00390376 |
| 92 | * IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.99939127 |
| 93 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.98963827 |
| 94 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.98767555 |
| 95 | UTX_26944678_Chip-Seq_JUKART_Human | 0.97886492 |
| 96 | * CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.97824986 |
| 97 | MAF_26560356_Chip-Seq_TH1_Human | 0.97553921 |
| 98 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.96633270 |
| 99 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.96005108 |
| 100 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.94139799 |
| 101 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.93936843 |
| 102 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.92559213 |
| 103 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.92223856 |
| 104 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.91976843 |
| 105 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.91811854 |
| 106 | MAF_26560356_Chip-Seq_TH2_Human | 0.91587350 |
| 107 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.91031053 |
| 108 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.89616667 |
| 109 | * OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.88028844 |
| 110 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.86753124 |
| 111 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.86033300 |
| 112 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.85153497 |
| 113 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.84653997 |
| 114 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.81614002 |
| 115 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.81402333 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0006292_abnormal_olfactory_placode | 4.34458693 |
| 2 | MP0003693_abnormal_embryo_hatching | 4.02356521 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 3.60750705 |
| 4 | MP0010094_abnormal_chromosome_stability | 3.08938436 |
| 5 | MP0003111_abnormal_nucleus_morphology | 2.95931896 |
| 6 | MP0003077_abnormal_cell_cycle | 2.89930753 |
| 7 | MP0008007_abnormal_cellular_replicative | 2.44199175 |
| 8 | MP0008057_abnormal_DNA_replication | 2.33535225 |
| 9 | MP0000566_synostosis | 2.22326465 |
| 10 | MP0002396_abnormal_hematopoietic_system | 2.17507840 |
| 11 | MP0008932_abnormal_embryonic_tissue | 2.16127145 |
| 12 | MP0008995_early_reproductive_senescence | 2.10379621 |
| 13 | MP0003941_abnormal_skin_development | 1.97120168 |
| 14 | MP0010352_gastrointestinal_tract_polyps | 1.95700923 |
| 15 | MP0000490_abnormal_crypts_of | 1.94302003 |
| 16 | MP0008058_abnormal_DNA_repair | 1.92203613 |
| 17 | MP0003186_abnormal_redox_activity | 1.87990340 |
| 18 | MP0000350_abnormal_cell_proliferation | 1.78765480 |
| 19 | MP0010030_abnormal_orbit_morphology | 1.75818082 |
| 20 | MP0003763_abnormal_thymus_physiology | 1.75626064 |
| 21 | MP0002697_abnormal_eye_size | 1.68816630 |
| 22 | MP0003786_premature_aging | 1.68040166 |
| 23 | MP0001286_abnormal_eye_development | 1.63320916 |
| 24 | MP0004808_abnormal_hematopoietic_stem | 1.61089333 |
| 25 | MP0009333_abnormal_splenocyte_physiolog | 1.59655280 |
| 26 | MP0001730_embryonic_growth_arrest | 1.54850385 |
| 27 | MP0003303_peritoneal_inflammation | 1.51622082 |
| 28 | * MP0009379_abnormal_foot_pigmentation | 1.48379324 |
| 29 | MP0002009_preneoplasia | 1.47097412 |
| 30 | MP0000537_abnormal_urethra_morphology | 1.44938176 |
| 31 | MP0000049_abnormal_middle_ear | 1.44151192 |
| 32 | MP0003938_abnormal_ear_development | 1.42499717 |
| 33 | MP0005408_hypopigmentation | 1.40282117 |
| 34 | MP0008789_abnormal_olfactory_epithelium | 1.38256131 |
| 35 | MP0003890_abnormal_embryonic-extraembry | 1.36071065 |
| 36 | MP0000372_irregular_coat_pigmentation | 1.32286505 |
| 37 | MP0002210_abnormal_sex_determination | 1.31021891 |
| 38 | MP0000703_abnormal_thymus_morphology | 1.30394836 |
| 39 | MP0002019_abnormal_tumor_incidence | 1.30086414 |
| 40 | MP0005076_abnormal_cell_differentiation | 1.29842177 |
| 41 | MP0002398_abnormal_bone_marrow | 1.29364560 |
| 42 | MP0006054_spinal_hemorrhage | 1.28070559 |
| 43 | MP0001697_abnormal_embryo_size | 1.27737279 |
| 44 | MP0003567_abnormal_fetal_cardiomyocyte | 1.26161882 |
| 45 | MP0000685_abnormal_immune_system | 1.26142507 |
| 46 | MP0010307_abnormal_tumor_latency | 1.24785384 |
| 47 | MP0003123_paternal_imprinting | 1.24555315 |
| 48 | MP0002277_abnormal_respiratory_mucosa | 1.24346080 |
| 49 | MP0005501_abnormal_skin_physiology | 1.22891504 |
| 50 | MP0000858_altered_metastatic_potential | 1.22468999 |
| 51 | MP0002722_abnormal_immune_system | 1.21318657 |
| 52 | MP0002092_abnormal_eye_morphology | 1.20186820 |
| 53 | MP0005499_abnormal_olfactory_system | 1.19726887 |
| 54 | MP0005394_taste/olfaction_phenotype | 1.19726887 |
| 55 | * MP0002080_prenatal_lethality | 1.18322114 |
| 56 | MP0001800_abnormal_humoral_immune | 1.17771126 |
| 57 | MP0000750_abnormal_muscle_regeneration | 1.16786672 |
| 58 | MP0005174_abnormal_tail_pigmentation | 1.16742540 |
| 59 | MP0002085_abnormal_embryonic_tissue | 1.15914612 |
| 60 | MP0001672_abnormal_embryogenesis/_devel | 1.15580650 |
| 61 | MP0005380_embryogenesis_phenotype | 1.15580650 |
| 62 | MP0000313_abnormal_cell_death | 1.15290016 |
| 63 | MP0001545_abnormal_hematopoietic_system | 1.13501420 |
| 64 | MP0005397_hematopoietic_system_phenotyp | 1.13501420 |
| 65 | MP0000689_abnormal_spleen_morphology | 1.11050655 |
| 66 | MP0002084_abnormal_developmental_patter | 1.09568741 |
| 67 | MP0002166_altered_tumor_susceptibility | 1.08756155 |
| 68 | MP0002086_abnormal_extraembryonic_tissu | 1.08605226 |
| 69 | MP0005666_abnormal_adipose_tissue | 1.07475219 |
| 70 | MP0009053_abnormal_anal_canal | 1.07001872 |
| 71 | MP0002796_impaired_skin_barrier | 1.06757647 |
| 72 | MP0008438_abnormal_cutaneous_collagen | 1.06714678 |
| 73 | MP0002088_abnormal_embryonic_growth/wei | 1.05555928 |
| 74 | MP0000428_abnormal_craniofacial_morphol | 1.05413005 |
| 75 | MP0004197_abnormal_fetal_growth/weight/ | 1.05010519 |
| 76 | MP0003984_embryonic_growth_retardation | 1.04731443 |
| 77 | MP0005023_abnormal_wound_healing | 1.04491702 |
| 78 | MP0003566_abnormal_cell_adhesion | 1.04481270 |
| 79 | MP0003718_maternal_effect | 1.04303254 |
| 80 | MP0003436_decreased_susceptibility_to | 1.02814190 |
| 81 | MP0001346_abnormal_lacrimal_gland | 1.02723504 |
| 82 | MP0001145_abnormal_male_reproductive | 1.02667087 |
| 83 | MP0002429_abnormal_blood_cell | 1.01774304 |
| 84 | MP0001835_abnormal_antigen_presentation | 1.01282154 |
| 85 | MP0002452_abnormal_antigen_presenting | 0.99563848 |
| 86 | MP0009672_abnormal_birth_weight | 0.99524526 |
| 87 | MP0002420_abnormal_adaptive_immunity | 0.98598920 |
| 88 | MP0002132_abnormal_respiratory_system | 0.98123865 |
| 89 | MP0002006_tumorigenesis | 0.97638292 |
| 90 | MP0002060_abnormal_skin_morphology | 0.97415352 |
| 91 | MP0000716_abnormal_immune_system | 0.96853214 |
| 92 | MP0003283_abnormal_digestive_organ | 0.96828378 |
| 93 | MP0001819_abnormal_immune_cell | 0.96610342 |
| 94 | MP0000762_abnormal_tongue_morphology | 0.94994067 |
| 95 | MP0010155_abnormal_intestine_physiology | 0.94774910 |
| 96 | MP0003828_pulmonary_edema | 0.94661400 |
| 97 | MP0005075_abnormal_melanosome_morpholog | 0.93823200 |
| 98 | MP0000631_abnormal_neuroendocrine_gland | 0.93206630 |
| 99 | MP0003136_yellow_coat_color | 0.92706483 |
| 100 | MP0003959_abnormal_lean_body | 0.92175951 |
| 101 | MP0003453_abnormal_keratinocyte_physiol | 0.92094717 |
| 102 | MP0003937_abnormal_limbs/digits/tail_de | 0.90573984 |
| 103 | MP0003724_increased_susceptibility_to | 0.90279200 |
| 104 | MP0000465_gastrointestinal_hemorrhage | 0.89877705 |
| 105 | MP0002405_respiratory_system_inflammati | 0.89084981 |
| 106 | MP0001881_abnormal_mammary_gland | 0.88992142 |
| 107 | MP0004381_abnormal_hair_follicle | 0.87565567 |
| 108 | MP0005275_abnormal_skin_tensile | 0.87490092 |
| 109 | MP0004185_abnormal_adipocyte_glucose | 0.87297925 |
| 110 | MP0002723_abnormal_immune_serum | 0.86832903 |
| 111 | MP0002233_abnormal_nose_morphology | 0.86332608 |
| 112 | MP0005000_abnormal_immune_tolerance | 0.85905840 |
| 113 | MP0002111_abnormal_tail_morphology | 0.85680799 |
| 114 | MP0001216_abnormal_epidermal_layer | 0.85579415 |
| 115 | MP0001293_anophthalmia | 0.83803718 |
| 116 | MP0005671_abnormal_response_to | 0.83448983 |
| 117 | MP0003300_gastrointestinal_ulcer | 0.82947692 |
| 118 | MP0001929_abnormal_gametogenesis | 0.82122900 |
| 119 | MP0003448_altered_tumor_morphology | 0.81509049 |
| 120 | MP0009278_abnormal_bone_marrow | 0.81224075 |
| 121 | MP0001243_abnormal_dermal_layer | 0.81220296 |
| 122 | MP0003705_abnormal_hypodermis_morpholog | 0.80846803 |
| 123 | MP0003315_abnormal_perineum_morphology | 0.80458878 |
| 124 | MP0002163_abnormal_gland_morphology | 0.80069694 |
| 125 | MP0002653_abnormal_ependyma_morphology | 0.79987059 |
| 126 | MP0001853_heart_inflammation | 0.79631161 |
| 127 | MP0000653_abnormal_sex_gland | 0.78665216 |
| 128 | MP0002160_abnormal_reproductive_system | 0.78170365 |
| 129 | MP0003878_abnormal_ear_physiology | 0.77968053 |
| 130 | MP0005377_hearing/vestibular/ear_phenot | 0.77968053 |
| 131 | MP0005025_abnormal_response_to | 0.77851386 |
| 132 | MP0005503_abnormal_tendon_morphology | 0.77411321 |
| 133 | MP0003806_abnormal_nucleotide_metabolis | 0.77363176 |
| 134 | MP0002249_abnormal_larynx_morphology | 0.76496302 |
| 135 | MP0002877_abnormal_melanocyte_morpholog | 0.76053006 |
| 136 | MP0002638_abnormal_pupillary_reflex | 0.75507971 |
| 137 | MP0002098_abnormal_vibrissa_morphology | 0.75283390 |
| 138 | MP0006036_abnormal_mitochondrial_physio | 0.75230618 |
| 139 | MP0000613_abnormal_salivary_gland | 0.74551824 |
| 140 | MP0002282_abnormal_trachea_morphology | 0.74378212 |
| 141 | MP0002148_abnormal_hypersensitivity_rea | 0.74215724 |
| 142 | MP0000477_abnormal_intestine_morphology | 0.73743094 |
| 143 | MP0001873_stomach_inflammation | 0.73300110 |
| 144 | MP0001348_abnormal_lacrimal_gland | 0.73257060 |
| 145 | MP0009697_abnormal_copulation | 0.72339022 |
| 146 | MP0005389_reproductive_system_phenotype | 0.72176499 |
| 147 | MP0001919_abnormal_reproductive_system | 0.71727245 |
| 148 | MP0002938_white_spotting | 0.71245651 |
| 149 | MP0005379_endocrine/exocrine_gland_phen | 0.69904587 |
| 150 | MP0008961_abnormal_basal_metabolism | 0.69680354 |
| 151 | MP0009250_abnormal_appendicular_skeleto | 0.68380191 |
| 152 | MP0001529_abnormal_vocalization | 0.66312650 |
| 153 | MP0005381_digestive/alimentary_phenotyp | 0.66177162 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Reticulocytopenia (HP:0001896) | 8.11760210 |
| 2 | Abnormality of cells of the erythroid lineage (HP:0012130) | 7.69326986 |
| 3 | Abnormal number of erythroid precursors (HP:0012131) | 6.89728950 |
| 4 | Macrocytic anemia (HP:0001972) | 5.90556672 |
| 5 | Pallor (HP:0000980) | 5.49611814 |
| 6 | Abnormal hemoglobin (HP:0011902) | 4.35803897 |
| 7 | Lipid accumulation in hepatocytes (HP:0006561) | 4.00798947 |
| 8 | Acute necrotizing encephalopathy (HP:0006965) | 3.75053880 |
| 9 | Colon cancer (HP:0003003) | 3.69352089 |
| 10 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.67517938 |
| 11 | Thrombocytosis (HP:0001894) | 3.55995923 |
| 12 | Septo-optic dysplasia (HP:0100842) | 3.48427970 |
| 13 | Mitochondrial inheritance (HP:0001427) | 3.47705612 |
| 14 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.41116619 |
| 15 | Renal Fanconi syndrome (HP:0001994) | 3.24130728 |
| 16 | Acute encephalopathy (HP:0006846) | 3.19161011 |
| 17 | Increased intramyocellular lipid droplets (HP:0012240) | 3.18548804 |
| 18 | Respiratory difficulties (HP:0002880) | 3.13654589 |
| 19 | Congenital, generalized hypertrichosis (HP:0004540) | 2.96794554 |
| 20 | Absent thumb (HP:0009777) | 2.95125288 |
| 21 | Trismus (HP:0000211) | 2.93425867 |
| 22 | 11 pairs of ribs (HP:0000878) | 2.91542831 |
| 23 | Maternal diabetes (HP:0009800) | 2.85046574 |
| 24 | Increased CSF lactate (HP:0002490) | 2.84744782 |
| 25 | Progressive macrocephaly (HP:0004481) | 2.82289175 |
| 26 | Increased muscle lipid content (HP:0009058) | 2.80266841 |
| 27 | Abnormality of reticulocytes (HP:0004312) | 2.79760538 |
| 28 | Hepatocellular necrosis (HP:0001404) | 2.76876325 |
| 29 | Abnormality of the parietal bone (HP:0002696) | 2.76793417 |
| 30 | Aplastic anemia (HP:0001915) | 2.70298360 |
| 31 | Depressed nasal ridge (HP:0000457) | 2.67192556 |
| 32 | Oral leukoplakia (HP:0002745) | 2.64454233 |
| 33 | Breast hypoplasia (HP:0003187) | 2.57801375 |
| 34 | Selective tooth agenesis (HP:0001592) | 2.49616154 |
| 35 | Duplication of thumb phalanx (HP:0009942) | 2.44231429 |
| 36 | Cerebral edema (HP:0002181) | 2.44165045 |
| 37 | Triphalangeal thumb (HP:0001199) | 2.42499552 |
| 38 | Rough bone trabeculation (HP:0100670) | 2.40921636 |
| 39 | Multiple enchondromatosis (HP:0005701) | 2.37030899 |
| 40 | 3-Methylglutaconic aciduria (HP:0003535) | 2.34731545 |
| 41 | Hepatic necrosis (HP:0002605) | 2.33848647 |
| 42 | Thick lower lip vermilion (HP:0000179) | 2.29461912 |
| 43 | Birth length less than 3rd percentile (HP:0003561) | 2.27049797 |
| 44 | Missing ribs (HP:0000921) | 2.23180756 |
| 45 | Microvesicular hepatic steatosis (HP:0001414) | 2.23067713 |
| 46 | Absent septum pellucidum (HP:0001331) | 2.22865141 |
| 47 | Woolly hair (HP:0002224) | 2.19579629 |
| 48 | Rib fusion (HP:0000902) | 2.18080634 |
| 49 | Basal cell carcinoma (HP:0002671) | 2.16255698 |
| 50 | Nasolacrimal duct obstruction (HP:0000579) | 2.15731106 |
| 51 | Migraine (HP:0002076) | 2.15116062 |
| 52 | Protrusio acetabuli (HP:0003179) | 2.13472021 |
| 53 | Sparse lateral eyebrow (HP:0005338) | 2.13319544 |
| 54 | Atresia of the external auditory canal (HP:0000413) | 2.10456085 |
| 55 | Myelodysplasia (HP:0002863) | 2.09941782 |
| 56 | Abnormality of the septum pellucidum (HP:0007375) | 2.09474935 |
| 57 | Asplenia (HP:0001746) | 2.07915078 |
| 58 | Neoplasm of the pancreas (HP:0002894) | 2.00788090 |
| 59 | Hypoplasia of the radius (HP:0002984) | 1.99561899 |
| 60 | Exercise intolerance (HP:0003546) | 1.99539620 |
| 61 | IgM deficiency (HP:0002850) | 1.96169176 |
| 62 | Carpal bone hypoplasia (HP:0001498) | 1.95396885 |
| 63 | Glossoptosis (HP:0000162) | 1.95324285 |
| 64 | Abnormality of the preputium (HP:0100587) | 1.94802076 |
| 65 | Abnormality of renal resorption (HP:0011038) | 1.93728023 |
| 66 | Stenosis of the external auditory canal (HP:0000402) | 1.93385138 |
| 67 | Exertional dyspnea (HP:0002875) | 1.92432043 |
| 68 | Cleft eyelid (HP:0000625) | 1.91345891 |
| 69 | Premature rupture of membranes (HP:0001788) | 1.90999424 |
| 70 | Leukodystrophy (HP:0002415) | 1.88786010 |
| 71 | Sparse eyelashes (HP:0000653) | 1.88641479 |
| 72 | Rhabdomyosarcoma (HP:0002859) | 1.88508659 |
| 73 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.87429749 |
| 74 | Abnormality of the lacrimal duct (HP:0011481) | 1.86997609 |
| 75 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.85624927 |
| 76 | Patellar aplasia (HP:0006443) | 1.84717859 |
| 77 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.84648488 |
| 78 | Hyperphosphaturia (HP:0003109) | 1.81789797 |
| 79 | Meckel diverticulum (HP:0002245) | 1.78531702 |
| 80 | Down-sloping shoulders (HP:0200021) | 1.78503890 |
| 81 | Chromsome breakage (HP:0040012) | 1.77828275 |
| 82 | Partial duplication of the phalanx of hand (HP:0009999) | 1.76958484 |
| 83 | Proximal placement of thumb (HP:0009623) | 1.76782114 |
| 84 | Premature graying of hair (HP:0002216) | 1.76494049 |
| 85 | Lactic acidosis (HP:0003128) | 1.75208453 |
| 86 | Absent radius (HP:0003974) | 1.74853306 |
| 87 | Increased hepatocellular lipid droplets (HP:0006565) | 1.74296814 |
| 88 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.73804153 |
| 89 | Abnormality of abdominal situs (HP:0011620) | 1.73509711 |
| 90 | Abdominal situs inversus (HP:0003363) | 1.73509711 |
| 91 | Entropion (HP:0000621) | 1.73296029 |
| 92 | Increased density of long bones (HP:0006392) | 1.72723926 |
| 93 | Microretrognathia (HP:0000308) | 1.71868040 |
| 94 | Abnormal number of incisors (HP:0011064) | 1.71840743 |
| 95 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.71349076 |
| 96 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.71349076 |
| 97 | Abnormality of the ileum (HP:0001549) | 1.70175448 |
| 98 | Respiratory failure (HP:0002878) | 1.69915533 |
| 99 | Abnormality of chromosome stability (HP:0003220) | 1.69504908 |
| 100 | Tracheoesophageal fistula (HP:0002575) | 1.69229622 |
| 101 | Abnormal trabecular bone morphology (HP:0100671) | 1.69123746 |
| 102 | Abnormality of the nasolacrimal system (HP:0000614) | 1.68644303 |
| 103 | Squamous cell carcinoma (HP:0002860) | 1.68304712 |
| 104 | Concave nail (HP:0001598) | 1.68094972 |
| 105 | Horseshoe kidney (HP:0000085) | 1.67698711 |
| 106 | Lymphoma (HP:0002665) | 1.67264787 |
| 107 | Increased serum lactate (HP:0002151) | 1.66444579 |
| 108 | Deviation of the thumb (HP:0009603) | 1.66011461 |
| 109 | Progressive muscle weakness (HP:0003323) | 1.65530169 |
| 110 | Cellular immunodeficiency (HP:0005374) | 1.65034999 |
| 111 | Secondary amenorrhea (HP:0000869) | 1.64773381 |
| 112 | Rectal prolapse (HP:0002035) | 1.64279677 |
| 113 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 1.64097814 |
| 114 | Amaurosis fugax (HP:0100576) | 1.63840911 |
| 115 | Recurrent bronchitis (HP:0002837) | 1.59800822 |
| 116 | Poikiloderma (HP:0001029) | 1.58958626 |
| 117 | Broad distal phalanx of finger (HP:0009836) | 1.58925239 |
| 118 | Colitis (HP:0002583) | 1.58823426 |
| 119 | Short nose (HP:0003196) | 1.58802073 |
| 120 | Medulloblastoma (HP:0002885) | 1.58092440 |
| 121 | Absent forearm bone (HP:0003953) | 1.57936543 |
| 122 | Aplasia involving forearm bones (HP:0009822) | 1.57936543 |
| 123 | Cellulitis (HP:0100658) | 1.55265533 |
| 124 | Dysphonia (HP:0001618) | 1.55047070 |
| 125 | Optic disc pallor (HP:0000543) | 1.54614114 |
| 126 | Abnormal urine phosphate concentration (HP:0012599) | 1.54516151 |
| 127 | Facial cleft (HP:0002006) | 1.53230276 |
| 128 | Bilateral microphthalmos (HP:0007633) | 1.52811894 |
| 129 | Degeneration of anterior horn cells (HP:0002398) | 1.52386318 |
| 130 | Abnormality of the anterior horn cell (HP:0006802) | 1.52386318 |
| 131 | Panhypogammaglobulinemia (HP:0003139) | 1.50911704 |
| 132 | Short middle phalanx of the 5th finger (HP:0004220) | 1.50691394 |
| 133 | Progressive external ophthalmoplegia (HP:0000590) | 1.50582730 |
| 134 | Acute lymphatic leukemia (HP:0006721) | 1.49760663 |
| 135 | Duplicated collecting system (HP:0000081) | 1.49127301 |
| 136 | Sparse scalp hair (HP:0002209) | 1.48891720 |
| 137 | Elevated erythrocyte sedimentation rate (HP:0003565) | 1.48863243 |
| 138 | Partial duplication of thumb phalanx (HP:0009944) | 1.48429098 |
| 139 | Neoplasm of the colon (HP:0100273) | 1.48343786 |
| 140 | Thoracic kyphosis (HP:0002942) | 1.48093485 |
| 141 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.47909686 |
| 142 | Pancytopenia (HP:0001876) | 1.47130207 |
| 143 | Diastasis recti (HP:0001540) | 1.46605762 |
| 144 | Supernumerary spleens (HP:0009799) | 1.45963094 |
| 145 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.44987042 |
| 146 | Duodenal stenosis (HP:0100867) | 1.44726339 |
| 147 | Small intestinal stenosis (HP:0012848) | 1.44726339 |
| 148 | Ependymoma (HP:0002888) | 1.44396388 |
| 149 | Soft skin (HP:0000977) | 1.43873005 |
| 150 | Esophageal atresia (HP:0002032) | 1.41909019 |
| 151 | Abnormality of DNA repair (HP:0003254) | 1.39369667 |
| 152 | Supernumerary ribs (HP:0005815) | 1.39043258 |
| 153 | Anophthalmia (HP:0000528) | 1.38026418 |
| 154 | Abnormality of cochlea (HP:0000375) | 1.36616711 |
| 155 | Forearm undergrowth (HP:0009821) | 1.34505906 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NME2 | 4.69338216 |
| 2 | VRK2 | 3.68252238 |
| 3 | TLK1 | 3.55457520 |
| 4 | BUB1 | 3.20701919 |
| 5 | WEE1 | 3.19421765 |
| 6 | EIF2AK1 | 2.92250551 |
| 7 | EEF2K | 2.58847728 |
| 8 | RPS6KB2 | 2.41168881 |
| 9 | CDC7 | 2.32098570 |
| 10 | NEK2 | 2.11178474 |
| 11 | SRPK1 | 2.02378127 |
| 12 | LRRK2 | 1.98526391 |
| 13 | PIM2 | 1.91347504 |
| 14 | TGFBR1 | 1.78422170 |
| 15 | MAP4K1 | 1.78349739 |
| 16 | DYRK3 | 1.78213151 |
| 17 | TESK2 | 1.77347455 |
| 18 | VRK1 | 1.72231707 |
| 19 | ZAK | 1.70709945 |
| 20 | PKN2 | 1.70508916 |
| 21 | PRPF4B | 1.67243097 |
| 22 | CDK7 | 1.57447099 |
| 23 | PASK | 1.57398764 |
| 24 | RPS6KA4 | 1.56835583 |
| 25 | MKNK1 | 1.55616015 |
| 26 | TAF1 | 1.52747200 |
| 27 | FLT3 | 1.51102997 |
| 28 | AURKB | 1.50370664 |
| 29 | MAP3K10 | 1.48372151 |
| 30 | EPHB2 | 1.47693854 |
| 31 | STK10 | 1.40028839 |
| 32 | MST4 | 1.39998693 |
| 33 | STK16 | 1.36051636 |
| 34 | SMG1 | 1.34700641 |
| 35 | STK24 | 1.32846452 |
| 36 | EIF2AK3 | 1.32538976 |
| 37 | MKNK2 | 1.32488312 |
| 38 | TTK | 1.31698530 |
| 39 | PLK1 | 1.26881901 |
| 40 | PIM1 | 1.22554434 |
| 41 | ACVR1B | 1.21941049 |
| 42 | MAP3K8 | 1.19819168 |
| 43 | PAK4 | 1.14058304 |
| 44 | EPHA2 | 1.13007001 |
| 45 | TSSK6 | 1.10074293 |
| 46 | BRSK2 | 1.04998539 |
| 47 | BLK | 1.04211847 |
| 48 | CDK12 | 1.03821109 |
| 49 | CDK4 | 1.03059752 |
| 50 | DYRK2 | 1.01169256 |
| 51 | ATR | 1.00236647 |
| 52 | NEK9 | 0.98212713 |
| 53 | TEC | 0.95827672 |
| 54 | BTK | 0.92899538 |
| 55 | AURKA | 0.92307223 |
| 56 | STK4 | 0.92222173 |
| 57 | SCYL2 | 0.91993869 |
| 58 | MAPKAPK3 | 0.91251510 |
| 59 | NLK | 0.89300539 |
| 60 | TYRO3 | 0.88500040 |
| 61 | CDK6 | 0.86751490 |
| 62 | CLK1 | 0.86661717 |
| 63 | BRAF | 0.84465109 |
| 64 | ILK | 0.81262245 |
| 65 | ALK | 0.78459857 |
| 66 | CDK8 | 0.76810131 |
| 67 | IKBKB | 0.74844743 |
| 68 | CSNK2A2 | 0.73351511 |
| 69 | CHEK1 | 0.73077426 |
| 70 | MAPK15 | 0.72747331 |
| 71 | CDK9 | 0.72501844 |
| 72 | CHEK2 | 0.71759009 |
| 73 | ZAP70 | 0.71535890 |
| 74 | CDK19 | 0.71028846 |
| 75 | RPS6KA5 | 0.69393941 |
| 76 | SIK1 | 0.68428847 |
| 77 | KDR | 0.67292990 |
| 78 | GRK6 | 0.66721377 |
| 79 | TRIB3 | 0.65355286 |
| 80 | PNCK | 0.65289999 |
| 81 | DYRK1B | 0.64741140 |
| 82 | MAP3K11 | 0.61928148 |
| 83 | MAP2K3 | 0.60105496 |
| 84 | JAK3 | 0.59013749 |
| 85 | PAK2 | 0.58968816 |
| 86 | PAK1 | 0.57986018 |
| 87 | CSNK2A1 | 0.57983774 |
| 88 | PBK | 0.57756430 |
| 89 | ATM | 0.57222246 |
| 90 | TESK1 | 0.57043755 |
| 91 | NEK1 | 0.56645506 |
| 92 | EIF2AK2 | 0.55212159 |
| 93 | LATS2 | 0.54835475 |
| 94 | PLK4 | 0.53357209 |
| 95 | NME1 | 0.51706763 |
| 96 | PTK6 | 0.51632098 |
| 97 | DAPK3 | 0.51615706 |
| 98 | TYK2 | 0.51276700 |
| 99 | MELK | 0.51165750 |
| 100 | LCK | 0.50749703 |
| 101 | CDK2 | 0.50568068 |
| 102 | ABL2 | 0.48419997 |
| 103 | MARK3 | 0.48377711 |
| 104 | MAP3K3 | 0.48296665 |
| 105 | MAP3K13 | 0.48274679 |
| 106 | PLK3 | 0.47349099 |
| 107 | STK3 | 0.47265151 |
| 108 | BRSK1 | 0.46936556 |
| 109 | MAP2K2 | 0.45448423 |
| 110 | CSNK1E | 0.44976044 |
| 111 | KIT | 0.44675956 |
| 112 | CDK1 | 0.43601357 |
| 113 | RPS6KL1 | 0.43162150 |
| 114 | RPS6KC1 | 0.43162150 |
| 115 | RPS6KA1 | 0.40160351 |
| 116 | PRKCI | 0.39740024 |
| 117 | LYN | 0.38907973 |
| 118 | BMX | 0.38722659 |
| 119 | RPS6KA6 | 0.38489540 |
| 120 | FES | 0.37663366 |
| 121 | CSK | 0.36937120 |
| 122 | CDK3 | 0.36919054 |
| 123 | BRD4 | 0.36673785 |
| 124 | TBK1 | 0.35172520 |
| 125 | CSF1R | 0.34331008 |
| 126 | AKT1 | 0.31268683 |
| 127 | ITK | 0.26050707 |
| 128 | WNK4 | 0.25370759 |
| 129 | CDK11A | 0.24943461 |
| 130 | MTOR | 0.24398786 |
| 131 | AKT2 | 0.24189750 |
| 132 | MOS | 0.24128608 |
| 133 | FGFR1 | 0.23856738 |
| 134 | DMPK | 0.23380502 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * Ribosome_Homo sapiens_hsa03010 | 7.22798176 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 3.94947798 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 3.28208790 |
| 4 | Spliceosome_Homo sapiens_hsa03040 | 3.05299454 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.86511347 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.70861655 |
| 7 | Homologous recombination_Homo sapiens_hsa03440 | 2.56313207 |
| 8 | RNA transport_Homo sapiens_hsa03013 | 2.36843840 |
| 9 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.35484884 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.34204840 |
| 11 | Base excision repair_Homo sapiens_hsa03410 | 2.33456741 |
| 12 | Proteasome_Homo sapiens_hsa03050 | 2.30797986 |
| 13 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.11262269 |
| 14 | Cell cycle_Homo sapiens_hsa04110 | 1.93892492 |
| 15 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.84345684 |
| 16 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.70879532 |
| 17 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.56523513 |
| 18 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.54913037 |
| 19 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.52542647 |
| 20 | Basal transcription factors_Homo sapiens_hsa03022 | 1.48573516 |
| 21 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.47373621 |
| 22 | Protein export_Homo sapiens_hsa03060 | 1.44966635 |
| 23 | RNA degradation_Homo sapiens_hsa03018 | 1.44899252 |
| 24 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.38723276 |
| 25 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.33098519 |
| 26 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.23662193 |
| 27 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.23236473 |
| 28 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.15076797 |
| 29 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.13774299 |
| 30 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.08243455 |
| 31 | Sulfur relay system_Homo sapiens_hsa04122 | 1.06152565 |
| 32 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.93036481 |
| 33 | Purine metabolism_Homo sapiens_hsa00230 | 0.90146676 |
| 34 | Parkinsons disease_Homo sapiens_hsa05012 | 0.84514341 |
| 35 | HTLV-I infection_Homo sapiens_hsa05166 | 0.84313689 |
| 36 | Thyroid cancer_Homo sapiens_hsa05216 | 0.84047855 |
| 37 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.83000418 |
| 38 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.79238695 |
| 39 | Huntingtons disease_Homo sapiens_hsa05016 | 0.77977844 |
| 40 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.74954546 |
| 41 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.74181582 |
| 42 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.73760187 |
| 43 | Measles_Homo sapiens_hsa05162 | 0.71772919 |
| 44 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.68184263 |
| 45 | Bladder cancer_Homo sapiens_hsa05219 | 0.67615897 |
| 46 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.66980849 |
| 47 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.65892249 |
| 48 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.65500875 |
| 49 | Apoptosis_Homo sapiens_hsa04210 | 0.64806929 |
| 50 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.62381415 |
| 51 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.62361726 |
| 52 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.60077895 |
| 53 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.59999961 |
| 54 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.59112129 |
| 55 | Legionellosis_Homo sapiens_hsa05134 | 0.57231788 |
| 56 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.56712540 |
| 57 | Hepatitis B_Homo sapiens_hsa05161 | 0.55856079 |
| 58 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.54999312 |
| 59 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.54039460 |
| 60 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.53600392 |
| 61 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.51295615 |
| 62 | Shigellosis_Homo sapiens_hsa05131 | 0.51229531 |
| 63 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.47332432 |
| 64 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.46064530 |
| 65 | Leishmaniasis_Homo sapiens_hsa05140 | 0.46044042 |
| 66 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.45757487 |
| 67 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.45408918 |
| 68 | Alcoholism_Homo sapiens_hsa05034 | 0.43814914 |
| 69 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.43565310 |
| 70 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.43537695 |
| 71 | Viral myocarditis_Homo sapiens_hsa05416 | 0.43490015 |
| 72 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.43393146 |
| 73 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.42963834 |
| 74 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.42398219 |
| 75 | Pathways in cancer_Homo sapiens_hsa05200 | 0.42215432 |
| 76 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.41551678 |
| 77 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.41141761 |
| 78 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.40172710 |
| 79 | Colorectal cancer_Homo sapiens_hsa05210 | 0.39665296 |
| 80 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.39025160 |
| 81 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.38515038 |
| 82 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.38099592 |
| 83 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.37375669 |
| 84 | Influenza A_Homo sapiens_hsa05164 | 0.36080179 |
| 85 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.35854747 |
| 86 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.35520086 |
| 87 | Metabolic pathways_Homo sapiens_hsa01100 | 0.34633553 |
| 88 | Allograft rejection_Homo sapiens_hsa05330 | 0.33762922 |
| 89 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.33414420 |
| 90 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.33306997 |
| 91 | Alzheimers disease_Homo sapiens_hsa05010 | 0.32196104 |
| 92 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.32048811 |
| 93 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.30927106 |
| 94 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.30658262 |
| 95 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.30319250 |
| 96 | Asthma_Homo sapiens_hsa05310 | 0.29814296 |
| 97 | Malaria_Homo sapiens_hsa05144 | 0.29657379 |
| 98 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.29247056 |
| 99 | Prostate cancer_Homo sapiens_hsa05215 | 0.28146134 |
| 100 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.27514827 |
| 101 | Adherens junction_Homo sapiens_hsa04520 | 0.27027958 |
| 102 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.26401359 |
| 103 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.26239538 |
| 104 | Platelet activation_Homo sapiens_hsa04611 | 0.25320856 |
| 105 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.24649385 |
| 106 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.23603382 |
| 107 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.23179688 |
| 108 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.23034677 |
| 109 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.22959951 |
| 110 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.22919518 |
| 111 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.19506730 |
| 112 | Carbon metabolism_Homo sapiens_hsa01200 | 0.18952241 |
| 113 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.17238797 |
| 114 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.16153892 |
| 115 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.15483137 |
| 116 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.12938882 |
| 117 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.11575755 |
| 118 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.07713102 |
| 119 | Melanoma_Homo sapiens_hsa05218 | 0.03668568 |
| 120 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.01052469 |
| 121 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.00342151 |
| 122 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | -0.0179476 |
| 123 | VEGF signaling pathway_Homo sapiens_hsa04370 | -0.0151702 |
| 124 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | -0.0089113 |

