RPS20P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.62030325
2protein neddylation (GO:0045116)6.45430489
3auditory receptor cell differentiation (GO:0042491)6.35371749
4ribosomal small subunit assembly (GO:0000028)5.27682157
5forebrain neuron differentiation (GO:0021879)4.85282050
6viral transcription (GO:0019083)4.61041854
7translational termination (GO:0006415)4.46758840
8sequestering of actin monomers (GO:0042989)4.31939637
9prenylation (GO:0097354)4.17870105
10protein prenylation (GO:0018342)4.17870105
11ATP synthesis coupled proton transport (GO:0015986)4.11711863
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.11711863
13tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.11453777
14RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.11453777
15rRNA catabolic process (GO:0016075)4.08326576
16translational elongation (GO:0006414)4.00873883
17cotranslational protein targeting to membrane (GO:0006613)3.98731253
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.96191388
19DNA double-strand break processing (GO:0000729)3.93854301
20hair cell differentiation (GO:0035315)3.93731502
21protein targeting to ER (GO:0045047)3.91051758
22mechanosensory behavior (GO:0007638)3.90166429
23histone H2A acetylation (GO:0043968)3.80541066
24cell proliferation in forebrain (GO:0021846)3.79752773
25viral protein processing (GO:0019082)3.74967833
26establishment of protein localization to endoplasmic reticulum (GO:0072599)3.71888135
27segment specification (GO:0007379)3.70066203
28cellular response to interleukin-15 (GO:0071350)3.69304981
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.66992476
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.66236448
31protein localization to endoplasmic reticulum (GO:0070972)3.62873183
32nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.51703068
33spinal cord association neuron differentiation (GO:0021527)3.51348065
34viral life cycle (GO:0019058)3.45572350
35neuronal stem cell maintenance (GO:0097150)3.42631291
36base-excision repair, AP site formation (GO:0006285)3.37161457
37metallo-sulfur cluster assembly (GO:0031163)3.36989323
38iron-sulfur cluster assembly (GO:0016226)3.36989323
39ncRNA catabolic process (GO:0034661)3.33739380
40maturation of SSU-rRNA (GO:0030490)3.32777722
41regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.32560274
42somite development (GO:0061053)3.29836814
43cellular protein complex disassembly (GO:0043624)3.25500596
44negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.20826548
45pattern specification involved in kidney development (GO:0061004)3.17642305
46negative regulation of transcription regulatory region DNA binding (GO:2000678)3.16246417
47neuron fate determination (GO:0048664)3.16072230
48exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14524994
49chaperone-mediated protein transport (GO:0072321)3.09621032
50central nervous system myelination (GO:0022010)3.08845639
51axon ensheathment in central nervous system (GO:0032291)3.08845639
52negative regulation of organelle assembly (GO:1902116)3.07113977
53electron transport chain (GO:0022900)3.07046865
54respiratory electron transport chain (GO:0022904)3.06976529
55dendritic spine morphogenesis (GO:0060997)3.04600601
56mitochondrial respiratory chain complex I assembly (GO:0032981)3.02959832
57NADH dehydrogenase complex assembly (GO:0010257)3.02959832
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.02959832
59ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.01776151
60cerebral cortex neuron differentiation (GO:0021895)2.97299987
61endoderm formation (GO:0001706)2.95219105
62ribosomal small subunit biogenesis (GO:0042274)2.95166523
63intraciliary transport (GO:0042073)2.94594164
64inner ear receptor cell differentiation (GO:0060113)2.94068710
65tryptophan catabolic process (GO:0006569)2.93648040
66indole-containing compound catabolic process (GO:0042436)2.93648040
67indolalkylamine catabolic process (GO:0046218)2.93648040
68nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.93044326
69regulation of B cell receptor signaling pathway (GO:0050855)2.91294880
70termination of RNA polymerase III transcription (GO:0006386)2.91168976
71transcription elongation from RNA polymerase III promoter (GO:0006385)2.91168976
72protein complex biogenesis (GO:0070271)2.88823596
73neuron fate specification (GO:0048665)2.87953356
74indolalkylamine metabolic process (GO:0006586)2.85639361
75establishment of protein localization to mitochondrial membrane (GO:0090151)2.84980429
76negative regulation of response to food (GO:0032096)2.84010810
77negative regulation of appetite (GO:0032099)2.84010810
78fusion of sperm to egg plasma membrane (GO:0007342)2.81323761
79spliceosomal complex assembly (GO:0000245)2.78875652
80UTP metabolic process (GO:0046051)2.77905505
81hydrogen ion transmembrane transport (GO:1902600)2.77188485
82glyoxylate metabolic process (GO:0046487)2.75797368
83proton transport (GO:0015992)2.75778631
84protein targeting to membrane (GO:0006612)2.75519965
85kynurenine metabolic process (GO:0070189)2.74832611
86positive regulation of Notch signaling pathway (GO:0045747)2.73556223
87ether lipid metabolic process (GO:0046485)2.72108377
88mannosylation (GO:0097502)2.70062061
89parturition (GO:0007567)2.68274175
90activated T cell proliferation (GO:0050798)2.68000141
91cytoplasmic sequestering of transcription factor (GO:0042994)2.67893311
92translation (GO:0006412)2.67761778
93hydrogen transport (GO:0006818)2.67275282
94protein complex disassembly (GO:0043241)2.66561195
95positive regulation of triglyceride biosynthetic process (GO:0010867)2.65675763
96aldehyde catabolic process (GO:0046185)2.63796076
97positive regulation of cell fate commitment (GO:0010455)2.62375955
98transmission of nerve impulse (GO:0019226)2.61393345
99translational initiation (GO:0006413)2.60765640
100mast cell activation involved in immune response (GO:0002279)2.60575526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.93696272
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.26077637
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.75017128
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.33612438
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.12990705
6VDR_22108803_ChIP-Seq_LS180_Human2.80706882
7IRF1_19129219_ChIP-ChIP_H3396_Human2.53356973
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32906139
9ZNF274_21170338_ChIP-Seq_K562_Hela2.21350937
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.17713372
11EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.01665149
12EST1_17652178_ChIP-ChIP_JURKAT_Human1.92000826
13CBX2_27304074_Chip-Seq_ESCs_Mouse1.78157530
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77517299
15EZH2_27304074_Chip-Seq_ESCs_Mouse1.76004866
16IGF1R_20145208_ChIP-Seq_DFB_Human1.68900344
17BP1_19119308_ChIP-ChIP_Hs578T_Human1.65295924
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64129274
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62165321
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.62162151
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61332332
22GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.58029491
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57290656
24EWS_26573619_Chip-Seq_HEK293_Human1.55680802
25MYC_18940864_ChIP-ChIP_HL60_Human1.51742974
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51685501
27GATA3_21878914_ChIP-Seq_MCF-7_Human1.51575247
28ETV2_25802403_ChIP-Seq_MESCs_Mouse1.50598277
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48815612
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48446331
31ER_23166858_ChIP-Seq_MCF-7_Human1.47107208
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47104402
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.44991324
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44123763
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42890546
36FOXP3_21729870_ChIP-Seq_TREG_Human1.40999532
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40164239
38TP53_22573176_ChIP-Seq_HFKS_Human1.39618112
39MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39181022
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37924356
41VDR_23849224_ChIP-Seq_CD4+_Human1.36898803
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.34956197
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33222818
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33080854
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32204730
46CBP_20019798_ChIP-Seq_JUKART_Human1.32204730
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31536167
48REST_21632747_ChIP-Seq_MESCs_Mouse1.30505527
49AR_21572438_ChIP-Seq_LNCaP_Human1.29866491
50TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28965586
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26301298
52WDR5_24793694_ChIP-Seq_LNCAP_Human1.23944400
53RNF2_27304074_Chip-Seq_NSC_Mouse1.22940880
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22644321
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19346204
56CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.18950214
57SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18671601
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.18656094
59IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18631713
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18472360
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.17925282
62TAF2_19829295_ChIP-Seq_ESCs_Human1.16161539
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15400493
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15173944
65AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11596057
66JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10840504
67CIITA_25753668_ChIP-Seq_RAJI_Human1.08151061
68GATA3_21867929_ChIP-Seq_TH1_Mouse1.08062529
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07918472
70ELK1_19687146_ChIP-ChIP_HELA_Human1.07885195
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.07048582
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07048582
73NANOG_20526341_ChIP-Seq_ESCs_Human1.06708852
74ERG_20517297_ChIP-Seq_VCAP_Human1.05807917
75NCOR_22424771_ChIP-Seq_293T_Human1.04350168
76P53_21459846_ChIP-Seq_SAOS-2_Human1.03369566
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02930839
78BCL6_27268052_Chip-Seq_Bcells_Human1.02872659
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02311340
80NANOG_19829295_ChIP-Seq_ESCs_Human0.99249039
81SOX2_19829295_ChIP-Seq_ESCs_Human0.99249039
82AR_20517297_ChIP-Seq_VCAP_Human0.98021866
83ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96516838
84ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95789772
85GABP_19822575_ChIP-Seq_HepG2_Human0.95040163
86POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94741054
87P300_19829295_ChIP-Seq_ESCs_Human0.94464567
88SOX2_21211035_ChIP-Seq_LN229_Human0.93981148
89FUS_26573619_Chip-Seq_HEK293_Human0.93754506
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93645555
91E2F1_17053090_ChIP-ChIP_MCF-7_Human0.91336035
92FOXH1_21741376_ChIP-Seq_ESCs_Human0.91326608
93RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91259694
94OCT4_20526341_ChIP-Seq_ESCs_Human0.90743465
95CEBPB_22108803_ChIP-Seq_LS180_Human0.90163009
96ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88854039
97SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87839924
98FOXH1_21741376_ChIP-Seq_EPCs_Human0.87486278
99MYC_19829295_ChIP-Seq_ESCs_Human0.86654871
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86472811

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.23064953
2MP0009379_abnormal_foot_pigmentation4.72114454
3MP0002653_abnormal_ependyma_morphology3.06294551
4MP0001485_abnormal_pinna_reflex3.04388800
5MP0008789_abnormal_olfactory_epithelium2.85119690
6MP0003283_abnormal_digestive_organ2.49337259
7MP0005499_abnormal_olfactory_system2.40588691
8MP0005394_taste/olfaction_phenotype2.40588691
9MP0002102_abnormal_ear_morphology2.39123427
10MP0004142_abnormal_muscle_tone2.35930827
11MP0005645_abnormal_hypothalamus_physiol2.19029556
12MP0005377_hearing/vestibular/ear_phenot2.12576066
13MP0003878_abnormal_ear_physiology2.12576066
14MP0005551_abnormal_eye_electrophysiolog2.08228204
15MP0005084_abnormal_gallbladder_morpholo2.04498724
16MP0003938_abnormal_ear_development2.04193274
17MP0003787_abnormal_imprinting2.02840175
18MP0006072_abnormal_retinal_apoptosis1.92918669
19MP0000049_abnormal_middle_ear1.85210435
20MP0003646_muscle_fatigue1.84721011
21MP0008995_early_reproductive_senescence1.83490735
22MP0000631_abnormal_neuroendocrine_gland1.82204348
23MP0002876_abnormal_thyroid_physiology1.77104350
24MP0003183_abnormal_peptide_metabolism1.72650743
25MP0004742_abnormal_vestibular_system1.69652881
26MP0005083_abnormal_biliary_tract1.68283598
27MP0001293_anophthalmia1.67846917
28MP0003567_abnormal_fetal_cardiomyocyte1.63201951
29MP0004145_abnormal_muscle_electrophysio1.59351358
30MP0004133_heterotaxia1.58159633
31MP0008961_abnormal_basal_metabolism1.56721028
32MP0002638_abnormal_pupillary_reflex1.52643976
33MP0005451_abnormal_body_composition1.48562660
34MP0001919_abnormal_reproductive_system1.43052799
35MP0001348_abnormal_lacrimal_gland1.40513888
36MP0003136_yellow_coat_color1.36613930
37MP0005195_abnormal_posterior_eye1.36566504
38MP0008877_abnormal_DNA_methylation1.32336308
39MP0004885_abnormal_endolymph1.32195748
40MP0000778_abnormal_nervous_system1.31009812
41MP0006276_abnormal_autonomic_nervous1.30280183
42MP0000685_abnormal_immune_system1.27953212
43MP0005389_reproductive_system_phenotype1.21973910
44MP0002282_abnormal_trachea_morphology1.21454962
45MP0005671_abnormal_response_to1.20049718
46MP0002272_abnormal_nervous_system1.19633770
47MP0003122_maternal_imprinting1.19281688
48MP0002837_dystrophic_cardiac_calcinosis1.18972678
49MP0001873_stomach_inflammation1.17252816
50MP0008775_abnormal_heart_ventricle1.13247404
51MP0000026_abnormal_inner_ear1.12546175
52MP0008872_abnormal_physiological_respon1.11983602
53MP0000372_irregular_coat_pigmentation1.10388080
54MP0010386_abnormal_urinary_bladder1.10307572
55MP0005646_abnormal_pituitary_gland1.09102356
56MP0005253_abnormal_eye_physiology1.08560320
57MP0002557_abnormal_social/conspecific_i1.06577450
58MP0000427_abnormal_hair_cycle1.05141049
59MP0002933_joint_inflammation1.05049475
60MP0003880_abnormal_central_pattern1.01329074
61MP0002184_abnormal_innervation0.97287202
62MP0002752_abnormal_somatic_nervous0.96230804
63MP0001486_abnormal_startle_reflex0.95753552
64MP0002234_abnormal_pharynx_morphology0.94875860
65MP0001835_abnormal_antigen_presentation0.94689126
66MP0002160_abnormal_reproductive_system0.93128608
67MP0003121_genomic_imprinting0.90914532
68MP0009745_abnormal_behavioral_response0.90774358
69MP0005387_immune_system_phenotype0.87577353
70MP0001790_abnormal_immune_system0.87577353
71MP0001286_abnormal_eye_development0.86879021
72MP0003786_premature_aging0.85909133
73MP0002751_abnormal_autonomic_nervous0.85699529
74MP0002736_abnormal_nociception_after0.84525100
75MP0001529_abnormal_vocalization0.82781978
76MP0001970_abnormal_pain_threshold0.82667136
77MP0005670_abnormal_white_adipose0.82565263
78MP0001800_abnormal_humoral_immune0.82172268
79MP0002572_abnormal_emotion/affect_behav0.81281686
80MP0010155_abnormal_intestine_physiology0.80122869
81MP0003635_abnormal_synaptic_transmissio0.79907211
82MP0003890_abnormal_embryonic-extraembry0.79745997
83MP0002163_abnormal_gland_morphology0.79399564
84MP0009046_muscle_twitch0.78752126
85MP0002733_abnormal_thermal_nociception0.77631767
86MP0001440_abnormal_grooming_behavior0.76212002
87MP0003866_abnormal_defecation0.75930230
88MP0008875_abnormal_xenobiotic_pharmacok0.75627106
89MP0002233_abnormal_nose_morphology0.73524860
90MP0001963_abnormal_hearing_physiology0.72666036
91MP0009764_decreased_sensitivity_to0.72144838
92MP0001663_abnormal_digestive_system0.71754213
93MP0001984_abnormal_olfaction0.71156376
94MP0000230_abnormal_systemic_arterial0.69579287
95MP0000955_abnormal_spinal_cord0.69543834
96MP0002138_abnormal_hepatobiliary_system0.69289575
97MP0009785_altered_susceptibility_to0.66262360
98MP0005391_vision/eye_phenotype0.65937137
99MP0003123_paternal_imprinting0.62429162
100MP0002249_abnormal_larynx_morphology0.62390053

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)4.52113064
2IgG deficiency (HP:0004315)4.04695891
3Oligodactyly (hands) (HP:0001180)3.62939893
4Increased IgM level (HP:0003496)3.62866559
5Agitation (HP:0000713)3.54650819
6Cerebellar dysplasia (HP:0007033)3.39798132
7Medial flaring of the eyebrow (HP:0010747)3.38170497
8Retinal dysplasia (HP:0007973)3.36877581
9Reticulocytopenia (HP:0001896)3.30464021
10Thyroid-stimulating hormone excess (HP:0002925)3.22549941
11Nephronophthisis (HP:0000090)3.19663922
12Abnormality of midbrain morphology (HP:0002418)3.19451959
13Molar tooth sign on MRI (HP:0002419)3.19451959
14Hepatocellular necrosis (HP:0001404)3.18303662
15Acute necrotizing encephalopathy (HP:0006965)3.12625167
16Stomatitis (HP:0010280)3.12096349
17Chronic mucocutaneous candidiasis (HP:0002728)3.10914283
18Recurrent cutaneous fungal infections (HP:0011370)3.10914283
19Anterior segment dysgenesis (HP:0007700)3.05417191
20Septo-optic dysplasia (HP:0100842)3.03362742
21Pendular nystagmus (HP:0012043)2.98438275
22Abolished electroretinogram (ERG) (HP:0000550)2.97322104
23Absent rod-and cone-mediated responses on ERG (HP:0007688)2.95957154
24Mitochondrial inheritance (HP:0001427)2.89960568
25Abnormal mitochondria in muscle tissue (HP:0008316)2.88024761
26Oligodactyly (HP:0012165)2.87500793
27Congenital stationary night blindness (HP:0007642)2.82608375
28Lissencephaly (HP:0001339)2.82504890
29Increased CSF lactate (HP:0002490)2.81832221
30Acute encephalopathy (HP:0006846)2.80572813
31Elevated erythrocyte sedimentation rate (HP:0003565)2.80490225
32Abnormality of cells of the erythroid lineage (HP:0012130)2.77983523
33B lymphocytopenia (HP:0010976)2.76502721
34Hepatic necrosis (HP:0002605)2.75880859
35Optic disc pallor (HP:0000543)2.74460984
36Keratoconus (HP:0000563)2.72944621
37Increased corneal curvature (HP:0100692)2.72944621
38Abnormality of B cell number (HP:0010975)2.72664673
39Anophthalmia (HP:0000528)2.64594880
40Abnormal rod and cone electroretinograms (HP:0008323)2.62457086
41Gait imbalance (HP:0002141)2.61252170
42Decreased central vision (HP:0007663)2.60453640
43Absent thumb (HP:0009777)2.54637631
44IgA deficiency (HP:0002720)2.53760085
45Congenital primary aphakia (HP:0007707)2.45070076
46Progressive macrocephaly (HP:0004481)2.44034011
47Optic nerve hypoplasia (HP:0000609)2.39442121
48Pachygyria (HP:0001302)2.38053754
49True hermaphroditism (HP:0010459)2.32771194
50Abnormality of the renal medulla (HP:0100957)2.31548792
51Pancreatic cysts (HP:0001737)2.30339736
52Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.28182810
53Polydipsia (HP:0001959)2.27586922
54Abnormal drinking behavior (HP:0030082)2.27586922
55Nephrogenic diabetes insipidus (HP:0009806)2.26405862
56Colon cancer (HP:0003003)2.26306914
57Aplastic anemia (HP:0001915)2.25096574
58Aplasia/Hypoplasia of the spleen (HP:0010451)2.24154147
59Attenuation of retinal blood vessels (HP:0007843)2.18759362
60Fragile nails (HP:0001808)2.16494192
61Intestinal atresia (HP:0011100)2.15467366
62Hypoplasia of the ulna (HP:0003022)2.13271124
63Renal cortical cysts (HP:0000803)2.10028105
64Absent septum pellucidum (HP:0001331)2.09896212
65Abnormality of the renal cortex (HP:0011035)2.08418588
66Progressive cerebellar ataxia (HP:0002073)2.06863604
67Abnormal number of incisors (HP:0011064)2.05816220
68Abnormal number of erythroid precursors (HP:0012131)2.05708690
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.05194251
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.05194251
71Increased serum lactate (HP:0002151)2.03993268
72Adrenal hypoplasia (HP:0000835)2.03912276
73Impulsivity (HP:0100710)2.03124056
74Forearm undergrowth (HP:0009821)2.02795297
753-Methylglutaconic aciduria (HP:0003535)1.98634094
76Stenosis of the external auditory canal (HP:0000402)1.98284358
77Congenital, generalized hypertrichosis (HP:0004540)1.97393426
78Hypoplasia of the radius (HP:0002984)1.96186071
79Asplenia (HP:0001746)1.94138311
80Thyroiditis (HP:0100646)1.93886631
81Pancreatic fibrosis (HP:0100732)1.91631272
82Ectopic kidney (HP:0000086)1.91004765
83Severe combined immunodeficiency (HP:0004430)1.87874075
84Erythroderma (HP:0001019)1.87848342
85Volvulus (HP:0002580)1.87164363
86Horseshoe kidney (HP:0000085)1.83249010
87X-linked dominant inheritance (HP:0001423)1.81865791
88Aplasia/Hypoplasia of the ulna (HP:0006495)1.81488010
89Absent/shortened dynein arms (HP:0200106)1.81286860
90Dynein arm defect of respiratory motile cilia (HP:0012255)1.81286860
91Supernumerary spleens (HP:0009799)1.78985589
92Poor coordination (HP:0002370)1.77711596
93Lipid accumulation in hepatocytes (HP:0006561)1.77626597
94Postaxial hand polydactyly (HP:0001162)1.75243342
95T lymphocytopenia (HP:0005403)1.74403664
96Vaginal atresia (HP:0000148)1.74005693
97Severe muscular hypotonia (HP:0006829)1.73713107
98Increased hepatocellular lipid droplets (HP:0006565)1.71078426
99Tubular atrophy (HP:0000092)1.70718819
100Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.70624936

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.71778219
2MAP4K24.06254570
3EPHA33.45203313
4EPHB23.16373750
5BMPR1B2.64980571
6CDK82.55189235
7BCKDK2.35113901
8DYRK1B2.07596344
9TAOK31.99304736
10CASK1.97707722
11DYRK21.93257091
12FRK1.90377433
13GRK11.79608574
14ADRBK21.76164044
15WNK41.68716317
16BCR1.65143988
17MAP3K111.61457727
18OXSR11.57495596
19TNIK1.56590198
20TEC1.50510596
21PLK21.43909844
22GRK71.42953024
23MAP2K21.39223297
24PKN11.28484935
25TLK11.28355301
26WNK31.26229990
27EPHA41.25457733
28NUAK11.22325607
29KDR1.20686011
30STK391.18390238
31ZAK1.17757697
32TIE11.13602538
33MAP2K71.11541995
34PRKD30.97989701
35NTRK20.92940862
36MAP4K10.92666197
37PHKG10.91904366
38PHKG20.91904366
39ILK0.91456941
40PIK3CA0.89491203
41CDC70.87602762
42STK160.87403503
43MAPK130.87159957
44GRK60.84757474
45INSRR0.83583831
46PRKCH0.83471256
47DAPK30.82622142
48MARK10.82391268
49ITK0.81415718
50CAMK10.79234421
51VRK10.78894283
52PRKCG0.78088013
53PDK20.77176887
54RPS6KA60.76587353
55PRKD20.76434040
56PINK10.74783010
57TBK10.73252319
58GRK50.73082411
59CSF1R0.70610727
60DAPK20.68212887
61PLK40.65146431
62MAP2K60.62760868
63SYK0.62557163
64PRKCA0.62313681
65CSNK1G20.60936807
66MYLK0.60124568
67PRKACA0.60075054
68RPS6KA50.59735193
69STK110.59572017
70PRKCQ0.56944469
71IKBKB0.56772613
72MAP3K40.53749650
73CSNK1A10.52564190
74ADRBK10.52150009
75MUSK0.51962402
76AURKA0.51388266
77IRAK40.51384344
78MKNK20.51358125
79CSNK2A10.50726583
80TGFBR10.48861152
81CHUK0.48259959
82TYRO30.47454623
83VRK20.47362264
84BTK0.47301048
85OBSCN0.45565965
86KIT0.44705667
87LRRK20.44537063
88PIK3CG0.44314880
89PRKCD0.43870173
90CDK40.43486736
91NLK0.42652650
92TXK0.42367942
93RPS6KL10.40740623
94RPS6KC10.40740623
95ACVR1B0.39854646
96PRKCZ0.39522872
97PRKCE0.39133463
98IKBKE0.38673248
99CHEK20.38421190
100CDK190.37492677

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.43076693
2Oxidative phosphorylation_Homo sapiens_hsa001903.85025598
3Protein export_Homo sapiens_hsa030603.64722775
4Parkinsons disease_Homo sapiens_hsa050122.95079738
5Primary immunodeficiency_Homo sapiens_hsa053402.69356157
6Homologous recombination_Homo sapiens_hsa034402.67771676
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.42134494
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.41618880
9RNA polymerase_Homo sapiens_hsa030202.29945425
10Proteasome_Homo sapiens_hsa030502.29805726
11Asthma_Homo sapiens_hsa053102.09589457
12Cardiac muscle contraction_Homo sapiens_hsa042602.06287439
13Huntingtons disease_Homo sapiens_hsa050161.98298300
14Alzheimers disease_Homo sapiens_hsa050101.97381603
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.90941293
16Fanconi anemia pathway_Homo sapiens_hsa034601.87729501
17Phototransduction_Homo sapiens_hsa047441.83880960
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72539970
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71101563
20Basal transcription factors_Homo sapiens_hsa030221.68015543
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.65186104
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.58584179
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57691679
24Linoleic acid metabolism_Homo sapiens_hsa005911.55087810
25Butanoate metabolism_Homo sapiens_hsa006501.53493034
26Autoimmune thyroid disease_Homo sapiens_hsa053201.50562694
27Allograft rejection_Homo sapiens_hsa053301.48654650
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45270704
29Mismatch repair_Homo sapiens_hsa034301.43718906
30RNA degradation_Homo sapiens_hsa030181.43575782
31Peroxisome_Homo sapiens_hsa041461.42654619
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32392985
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31852369
34Ether lipid metabolism_Homo sapiens_hsa005651.23096296
35Olfactory transduction_Homo sapiens_hsa047401.22737522
36Tryptophan metabolism_Homo sapiens_hsa003801.20833472
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.17912379
38Propanoate metabolism_Homo sapiens_hsa006401.14206088
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11849798
40Pyrimidine metabolism_Homo sapiens_hsa002401.07875834
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06335446
42Nucleotide excision repair_Homo sapiens_hsa034201.03369267
43Graft-versus-host disease_Homo sapiens_hsa053320.95398131
44Purine metabolism_Homo sapiens_hsa002300.91761831
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.90311849
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87392391
47Regulation of autophagy_Homo sapiens_hsa041400.86900110
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86170691
49Nicotine addiction_Homo sapiens_hsa050330.85406367
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81973082
51Collecting duct acid secretion_Homo sapiens_hsa049660.80245878
52Morphine addiction_Homo sapiens_hsa050320.76312566
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76213388
54Hematopoietic cell lineage_Homo sapiens_hsa046400.75661410
55Arachidonic acid metabolism_Homo sapiens_hsa005900.73150193
56Fat digestion and absorption_Homo sapiens_hsa049750.69684305
57Folate biosynthesis_Homo sapiens_hsa007900.68833852
58Caffeine metabolism_Homo sapiens_hsa002320.68083922
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66027638
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64488448
61Antigen processing and presentation_Homo sapiens_hsa046120.64278169
62Hedgehog signaling pathway_Homo sapiens_hsa043400.63621593
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61754222
64Systemic lupus erythematosus_Homo sapiens_hsa053220.59272043
65Metabolic pathways_Homo sapiens_hsa011000.57782413
66Type I diabetes mellitus_Homo sapiens_hsa049400.57672813
67Non-homologous end-joining_Homo sapiens_hsa034500.57469838
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56859052
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56569978
70Rheumatoid arthritis_Homo sapiens_hsa053230.56125285
71Fatty acid degradation_Homo sapiens_hsa000710.53725422
72Salivary secretion_Homo sapiens_hsa049700.49230409
73Circadian entrainment_Homo sapiens_hsa047130.46881049
74Chemical carcinogenesis_Homo sapiens_hsa052040.45857600
75Viral myocarditis_Homo sapiens_hsa054160.44636992
76Serotonergic synapse_Homo sapiens_hsa047260.42967733
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.41081693
78Sphingolipid metabolism_Homo sapiens_hsa006000.39611826
79Taste transduction_Homo sapiens_hsa047420.38939959
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38018870
81Glutamatergic synapse_Homo sapiens_hsa047240.37325305
82Ovarian steroidogenesis_Homo sapiens_hsa049130.37173506
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36723337
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35022352
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.34925331
86T cell receptor signaling pathway_Homo sapiens_hsa046600.33590390
87Spliceosome_Homo sapiens_hsa030400.32720486
88Notch signaling pathway_Homo sapiens_hsa043300.32153294
89Glycerolipid metabolism_Homo sapiens_hsa005610.31266982
90beta-Alanine metabolism_Homo sapiens_hsa004100.30042139
91Fatty acid metabolism_Homo sapiens_hsa012120.29677103
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28878921
93Nitrogen metabolism_Homo sapiens_hsa009100.28764073
94Retinol metabolism_Homo sapiens_hsa008300.26816716
95GABAergic synapse_Homo sapiens_hsa047270.26633675
96One carbon pool by folate_Homo sapiens_hsa006700.24692971
97Cholinergic synapse_Homo sapiens_hsa047250.24533416
98Insulin secretion_Homo sapiens_hsa049110.24523598
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23354757
100Alcoholism_Homo sapiens_hsa050340.22042824

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