ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	7.84649766
2	GDP-mannose metabolic process (GO:0019673)	7.61038951
3	translational termination (GO:0006415)	7.43769526
4	mannose metabolic process (GO:0006013)	6.90867565
5	ribosomal small subunit biogenesis (GO:0042274)	6.85343037
6	translational elongation (GO:0006414)	6.60858225
7	ribosomal small subunit assembly (GO:0000028)	6.33052668
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.31743252
9	cotranslational protein targeting to membrane (GO:0006613)	6.22403765
10	nucleoside transmembrane transport (GO:1901642)	6.21522414
11	protein targeting to ER (GO:0045047)	6.18001927
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.88220165
13	protein localization to endoplasmic reticulum (GO:0070972)	5.75754601
14	DNA deamination (GO:0045006)	5.71377483
15	viral life cycle (GO:0019058)	5.64900614
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.60853596
17	ATP synthesis coupled proton transport (GO:0015986)	5.60853596
18	cellular protein complex disassembly (GO:0043624)	5.55981282
19	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.35975429
20	behavioral response to nicotine (GO:0035095)	5.15394066
21	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.99894102
22	maturation of SSU-rRNA (GO:0030490)	4.96603107
23	nucleoside transport (GO:0015858)	4.81512485
24	interferon-gamma production (GO:0032609)	4.78668768
25	translational initiation (GO:0006413)	4.69237380
26	protein complex disassembly (GO:0043241)	4.64850126
27	protein targeting to membrane (GO:0006612)	4.44034274
28	ribosomal large subunit biogenesis (GO:0042273)	4.33562001
29	macromolecular complex disassembly (GO:0032984)	4.29738785
30	cytidine metabolic process (GO:0046087)	4.26608305
31	cytidine catabolic process (GO:0006216)	4.26608305
32	cytidine deamination (GO:0009972)	4.26608305
33	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.24825542
34	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.20502167
35	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.14953703
36	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.14953703
37	translation (GO:0006412)	4.12776012
38	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.97222405
39	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.89094276
40	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.72311600
41	mRNA catabolic process (GO:0006402)	3.69537835
42	outer ear morphogenesis (GO:0042473)	3.66829502
43	response to pheromone (GO:0019236)	3.56388137
44	cell proliferation in forebrain (GO:0021846)	3.55805919
45	reproduction (GO:0000003)	3.53413300
46	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.51939314
47	water-soluble vitamin biosynthetic process (GO:0042364)	3.40893235
48	cellular component biogenesis (GO:0044085)	3.40380551
49	cofactor transport (GO:0051181)	3.28103714
50	modified amino acid transport (GO:0072337)	3.26255974
51	RNA catabolic process (GO:0006401)	3.25647055
52	ribonucleoprotein complex biogenesis (GO:0022613)	3.22793146
53	ATP biosynthetic process (GO:0006754)	3.18902369
54	protein neddylation (GO:0045116)	3.17491758
55	electron transport chain (GO:0022900)	3.16937395
56	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.16615346
57	respiratory electron transport chain (GO:0022904)	3.14017058
58	endoderm formation (GO:0001706)	3.13916033
59	intracellular protein transmembrane import (GO:0044743)	3.11855087
60	short-chain fatty acid metabolic process (GO:0046459)	2.96250497
61	coenzyme A biosynthetic process (GO:0015937)	2.94691564
62	somite development (GO:0061053)	2.94641956
63	establishment of protein localization to membrane (GO:0090150)	2.93255961
64	positive regulation of icosanoid secretion (GO:0032305)	2.90325533
65	phenylpropanoid metabolic process (GO:0009698)	2.89564076
66	positive regulation of fatty acid transport (GO:2000193)	2.88271410
67	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.88236655
68	otic vesicle formation (GO:0030916)	2.86929354
69	pantothenate metabolic process (GO:0015939)	2.85529057
70	meiotic chromosome segregation (GO:0045132)	2.84895939
71	protein complex biogenesis (GO:0070271)	2.83171732
72	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.82424953
73	positive regulation of defense response to virus by host (GO:0002230)	2.80036755
74	regulation of mitochondrial membrane potential (GO:0051881)	2.77969740
75	sulfur compound transport (GO:0072348)	2.76908803
76	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.75659434
77	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.75659434
78	protein targeting (GO:0006605)	2.74245583
79	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.73884153
80	peroxisome fission (GO:0016559)	2.73452377
81	cellular response to estradiol stimulus (GO:0071392)	2.72668845
82	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.71209635
83	pharyngeal system development (GO:0060037)	2.67614327
84	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.66386910
85	NADH dehydrogenase complex assembly (GO:0010257)	2.66386910
86	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.66386910
87	positive regulation of T cell apoptotic process (GO:0070234)	2.62779808
88	hydrogen ion transmembrane transport (GO:1902600)	2.62004269
89	positive regulation of transcription regulatory region DNA binding (GO:2000679)	2.52067911
90	lateral ventricle development (GO:0021670)	2.51611255
91	establishment of protein localization to organelle (GO:0072594)	2.51377330
92	negative regulation of cAMP-mediated signaling (GO:0043951)	2.49369847
93	positive regulation of fatty acid oxidation (GO:0046321)	2.48204488
94	indolalkylamine metabolic process (GO:0006586)	2.46301971
95	nucleotide-sugar biosynthetic process (GO:0009226)	2.46122432
96	cytolysis (GO:0019835)	2.42841202
97	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.42797402
98	protein polyglutamylation (GO:0018095)	2.41810052
99	mitochondrial respiratory chain complex assembly (GO:0033108)	2.41050115
100	chaperone-mediated protein transport (GO:0072321)	10.5620186

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	6.48851202
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.26874032
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.97261642
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.55092894
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.18430113
6	VDR_22108803_ChIP-Seq_LS180_Human	2.57834903
7	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.55051886
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.32353235
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.25067536
10	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.13383383
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.09786323
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.08912546
13	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.00014207
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.98718969
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.97578391
16	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.89263845
17	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.88612751
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.87151995
19	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.86318534
20	IGF1R_20145208_ChIP-Seq_DFB_Human	1.81778739
21	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.76671732
22	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.73631295
23	RNF2_27304074_Chip-Seq_NSC_Mouse	1.71443937
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.69876695
25	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.67101512
26	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.64346036
27	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.64286969
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.59852372
29	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.54428084
30	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.51879056
31	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.51639872
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.50630584
33	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.50071309
34	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.42542296
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35928799
36	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34213159
37	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.32535213
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.31180242
39	NANOG_20526341_ChIP-Seq_ESCs_Human	1.30810556
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.29847100
41	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.29524241
42	ELK1_19687146_ChIP-ChIP_HELA_Human	1.29314593
43	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.28016634
44	IRF1_19129219_ChIP-ChIP_H3396_Human	1.27756344
45	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.25895702
46	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.25770279
47	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.25269864
48	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.25118383
49	VDR_23849224_ChIP-Seq_CD4+_Human	1.23863168
50	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.22851270
51	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.19883811
52	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.19555078
53	MYC_18940864_ChIP-ChIP_HL60_Human	1.18796975
54	REST_21632747_ChIP-Seq_MESCs_Mouse	1.18680740
55	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.17036685
56	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.17036685
57	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.16846566
58	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.14706067
59	TAF2_19829295_ChIP-Seq_ESCs_Human	1.13783335
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13288107
61	NCOR_22424771_ChIP-Seq_293T_Human	1.12972140
62	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.12651755
63	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.12055076
64	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.09467525
65	HTT_18923047_ChIP-ChIP_STHdh_Human	1.09161796
66	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08060703
67	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.07809951
68	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.06524221
69	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.06496274
70	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05245224
71	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.05220616
72	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.04374644
73	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04084834
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02698188
75	RBPJ_21746931_ChIP-Seq_IB4_Human	1.02613175
76	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.02088489
77	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.01812059
78	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.00903404
79	ETV1_20927104_ChIP-Seq_GIST48_Human	1.00874656
80	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.00307960
81	SA1_27219007_Chip-Seq_Bcells_Human	1.00033750
82	ERG_20517297_ChIP-Seq_VCAP_Human	0.99790619
83	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.99407125
84	PHF8_20622853_ChIP-Seq_HELA_Human	0.99307120
85	SOX2_21211035_ChIP-Seq_LN229_Human	0.98446427
86	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97222633
87	FUS_26573619_Chip-Seq_HEK293_Human	0.97056011
88	MYC_19829295_ChIP-Seq_ESCs_Human	0.97021610
89	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.96457673
90	E2F1_20622854_ChIP-Seq_HELA_Human	0.95879324
91	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.95869689
92	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.95315717
93	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.95263235
94	AR_21572438_ChIP-Seq_LNCaP_Human	0.93948991
95	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.91927005
96	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.90185411
97	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.90056003
98	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.89393304
99	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.88606023
100	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.87751772

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	7.67317036
2	MP0002638_abnormal_pupillary_reflex	4.78571688
3	MP0006292_abnormal_olfactory_placode	4.27624569
4	MP0003646_muscle_fatigue	3.58969088
5	MP0006072_abnormal_retinal_apoptosis	2.51237307
6	MP0005671_abnormal_response_to	2.42749322
7	MP0002163_abnormal_gland_morphology	2.07012238
8	MP0008789_abnormal_olfactory_epithelium	2.04071190
9	MP0000049_abnormal_middle_ear	1.96488739
10	MP0001529_abnormal_vocalization	1.84841067
11	MP0001485_abnormal_pinna_reflex	1.80641421
12	MP0003787_abnormal_imprinting	1.78460235
13	MP0003011_delayed_dark_adaptation	1.75028129
14	MP0000372_irregular_coat_pigmentation	1.69306830
15	MP0005503_abnormal_tendon_morphology	1.68662645
16	MP0003878_abnormal_ear_physiology	1.66690212
17	MP0005377_hearing/vestibular/ear_phenot	1.66690212
18	MP0002160_abnormal_reproductive_system	1.60023673
19	MP0004142_abnormal_muscle_tone	1.59878082
20	MP0002837_dystrophic_cardiac_calcinosis	1.58057860
21	MP0008877_abnormal_DNA_methylation	1.57434314
22	MP0006276_abnormal_autonomic_nervous	1.52104899
23	MP0002277_abnormal_respiratory_mucosa	1.49697562
24	MP0003122_maternal_imprinting	1.46114725
25	MP0003880_abnormal_central_pattern	1.42377288
26	MP0000631_abnormal_neuroendocrine_gland	1.39290530
27	MP0005499_abnormal_olfactory_system	1.36490418
28	MP0005394_taste/olfaction_phenotype	1.36490418
29	MP0005389_reproductive_system_phenotype	1.35393384
30	MP0004043_abnormal_pH_regulation	1.34870791
31	MP0002234_abnormal_pharynx_morphology	1.34177967
32	MP0001293_anophthalmia	1.33476953
33	MP0001188_hyperpigmentation	1.32416764
34	MP0003136_yellow_coat_color	1.31544809
35	MP0005551_abnormal_eye_electrophysiolog	1.31416854
36	MP0001905_abnormal_dopamine_level	1.29093962
37	MP0002876_abnormal_thyroid_physiology	1.27188705
38	MP0002102_abnormal_ear_morphology	1.26640687
39	MP0005253_abnormal_eye_physiology	1.25664287
40	MP0004133_heterotaxia	1.24140053
41	MP0005379_endocrine/exocrine_gland_phen	1.23798793
42	MP0004145_abnormal_muscle_electrophysio	1.23022105
43	MP0001727_abnormal_embryo_implantation	1.21651540
44	MP0004885_abnormal_endolymph	1.19949293
45	MP0001873_stomach_inflammation	1.19570458
46	MP0005174_abnormal_tail_pigmentation	1.19318949
47	MP0000778_abnormal_nervous_system	1.18202508
48	MP0002095_abnormal_skin_pigmentation	1.15533130
49	MP0004742_abnormal_vestibular_system	1.15516964
50	MP0001968_abnormal_touch/_nociception	1.15021955
51	MP0005195_abnormal_posterior_eye	1.13462222
52	MP0000678_abnormal_parathyroid_gland	1.10440295
53	MP0002249_abnormal_larynx_morphology	1.10002813
54	MP0001790_abnormal_immune_system	1.07315762
55	MP0005387_immune_system_phenotype	1.07315762
56	MP0002272_abnormal_nervous_system	1.06879183
57	MP0003938_abnormal_ear_development	1.05756429
58	MP0003879_abnormal_hair_cell	1.05675605
59	MP0005645_abnormal_hypothalamus_physiol	1.05596095
60	MP0002938_white_spotting	1.00449654
61	MP0001986_abnormal_taste_sensitivity	0.99983844
62	MP0008872_abnormal_physiological_respon	0.97883040
63	MP0009250_abnormal_appendicular_skeleto	0.97108225
64	MP0009333_abnormal_splenocyte_physiolog	0.95615107
65	MP0001542_abnormal_bone_strength	0.93691761
66	MP0005423_abnormal_somatic_nervous	0.93349871
67	MP0000026_abnormal_inner_ear	0.92077280
68	MP0006082_CNS_inflammation	0.91886818
69	MP0003195_calcinosis	0.91808868
70	MP0005646_abnormal_pituitary_gland	0.90868272
71	MP0005409_darkened_coat_color	0.89828094
72	MP0002752_abnormal_somatic_nervous	0.87583871
73	MP0009745_abnormal_behavioral_response	0.87172103
74	MP0001970_abnormal_pain_threshold	0.87138764
75	MP0002733_abnormal_thermal_nociception	0.84598894
76	MP0002734_abnormal_mechanical_nocicepti	0.84550708
77	MP0003890_abnormal_embryonic-extraembry	0.82929218
78	MP0002184_abnormal_innervation	0.82108303
79	MP0001963_abnormal_hearing_physiology	0.80904035
80	MP0002557_abnormal_social/conspecific_i	0.80757757
81	MP0002572_abnormal_emotion/affect_behav	0.79621643
82	MP0003121_genomic_imprinting	0.79533649
83	MP0003567_abnormal_fetal_cardiomyocyte	0.79336302
84	MP0003283_abnormal_digestive_organ	0.79228833
85	MP0001919_abnormal_reproductive_system	0.78276027
86	MP0001502_abnormal_circadian_rhythm	0.76519585
87	MP0002736_abnormal_nociception_after	0.76144449
88	MP0002138_abnormal_hepatobiliary_system	0.72844774
89	MP0009764_decreased_sensitivity_to	0.71444102
90	MP0002063_abnormal_learning/memory/cond	0.71406417
91	MP0002210_abnormal_sex_determination	0.69856990
92	MP0000955_abnormal_spinal_cord	0.67934914
93	MP0003137_abnormal_impulse_conducting	0.66551543
94	MP0002177_abnormal_outer_ear	0.66141175
95	MP0002735_abnormal_chemical_nociception	0.65112220
96	MP0004924_abnormal_behavior	0.64981526
97	MP0005386_behavior/neurological_phenoty	0.64981526
98	MP0002822_catalepsy	0.64764210
99	MP0001663_abnormal_digestive_system	0.63751851
100	MP0003936_abnormal_reproductive_system	0.62353071

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Global brain atrophy (HP:0002283)	5.99212523
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.50950748
3	Methylmalonic acidemia (HP:0002912)	4.32899054
4	Hyperglycinemia (HP:0002154)	4.02110092
5	Hypobetalipoproteinemia (HP:0003563)	3.93841891
6	Dyskinesia (HP:0100660)	3.86356311
7	Macrocytic anemia (HP:0001972)	3.80355342
8	Patent foramen ovale (HP:0001655)	3.77593272
9	Reticulocytopenia (HP:0001896)	3.68392697
10	Stenosis of the external auditory canal (HP:0000402)	3.56222416
11	Agitation (HP:0000713)	3.50173848
12	Abnormality of the phalanges of the 2nd finger (HP:0009541)	3.41547833
13	Methylmalonic aciduria (HP:0012120)	3.36313090
14	Partial duplication of the phalanx of hand (HP:0009999)	3.34328984
15	Neurodegeneration (HP:0002180)	3.29107509
16	Acanthocytosis (HP:0001927)	3.26623451
17	Congenital stationary night blindness (HP:0007642)	3.25650098
18	Akinesia (HP:0002304)	3.17672720
19	Pallor (HP:0000980)	3.03054387
20	Lipid accumulation in hepatocytes (HP:0006561)	3.02558289
21	Abnormal number of erythroid precursors (HP:0012131)	2.96195195
22	Mitochondrial inheritance (HP:0001427)	2.91500813
23	Microretrognathia (HP:0000308)	2.88764052
24	Abnormality of midbrain morphology (HP:0002418)	2.88082184
25	Molar tooth sign on MRI (HP:0002419)	2.88082184
26	Restlessness (HP:0000711)	2.80365138
27	Increased hepatocellular lipid droplets (HP:0006565)	2.78719429
28	Broad distal phalanx of finger (HP:0009836)	2.77012881
29	Decreased muscle mass (HP:0003199)	2.62970471
30	Increased CSF lactate (HP:0002490)	2.61112352
31	Septo-optic dysplasia (HP:0100842)	2.61071600
32	Elevated erythrocyte sedimentation rate (HP:0003565)	2.60730494
33	Abnormality of alanine metabolism (HP:0010916)	2.58462216
34	Hyperalaninemia (HP:0003348)	2.58462216
35	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.58462216
36	Acute necrotizing encephalopathy (HP:0006965)	2.57440005
37	Hepatocellular necrosis (HP:0001404)	2.53812489
38	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.48715525
39	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.48280343
40	Abnormality of the parietal bone (HP:0002696)	2.40435723
41	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.39975872
42	Renal Fanconi syndrome (HP:0001994)	2.39325482
43	Amblyopia (HP:0000646)	2.35561454
44	Abnormality of vitamin B metabolism (HP:0004340)	2.31937629
45	Abnormal mitochondria in muscle tissue (HP:0008316)	2.26017032
46	Dysphonia (HP:0001618)	2.23228983
47	Large eyes (HP:0001090)	2.22379658
48	Hepatic necrosis (HP:0002605)	2.22279841
49	Acute encephalopathy (HP:0006846)	2.21296706
50	Absent thumb (HP:0009777)	2.21058494
51	Delayed CNS myelination (HP:0002188)	2.20603798
52	Hemiplegia (HP:0002301)	2.19077368
53	Morphological abnormality of the pyramidal tract (HP:0002062)	2.15605345
54	Abnormal rod and cone electroretinograms (HP:0008323)	2.11089515
55	Congenital, generalized hypertrichosis (HP:0004540)	2.10441904
56	Abnormality of serum amino acid levels (HP:0003112)	2.10048015
57	Abnormality of the 2nd finger (HP:0004100)	2.10039059
58	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.08967007
59	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.08967007
60	Abnormality of the phalanges of the hallux (HP:0010057)	2.07411580
61	Hypoplasia of the ulna (HP:0003022)	2.03147345
62	Brushfield spots (HP:0001088)	2.01840302
63	Parakeratosis (HP:0001036)	2.01697139
64	Increased intramyocellular lipid droplets (HP:0012240)	2.00797872
65	Increased muscle lipid content (HP:0009058)	1.99593890
66	Progressive macrocephaly (HP:0004481)	1.98904740
67	Medial flaring of the eyebrow (HP:0010747)	1.98353027
68	Diminished movement (HP:0002374)	1.97869058
69	Pancreatic cysts (HP:0001737)	1.94357985
70	Depressed nasal ridge (HP:0000457)	1.92911401
71	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.91770293
72	Pendular nystagmus (HP:0012043)	1.91177631
73	Abnormal number of incisors (HP:0011064)	1.90223382
74	Tubulointerstitial nephritis (HP:0001970)	1.88251760
75	Decreased central vision (HP:0007663)	1.87966341
76	CNS demyelination (HP:0007305)	1.87175735
77	Gait imbalance (HP:0002141)	1.85455642
78	3-Methylglutaconic aciduria (HP:0003535)	1.85121609
79	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.84193696
80	Colon cancer (HP:0003003)	1.83817018
81	Abnormality of the corticospinal tract (HP:0002492)	1.83215543
82	Carpal bone hypoplasia (HP:0001498)	1.81416398
83	Impulsivity (HP:0100710)	1.80323967
84	Congenital primary aphakia (HP:0007707)	1.79967313
85	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.79181998
86	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.79181998
87	Focal dystonia (HP:0004373)	1.78661990
88	Increased serum lactate (HP:0002151)	1.78501430
89	True hermaphroditism (HP:0010459)	1.78235724
90	Renal tubular dysfunction (HP:0000124)	1.77614948
91	Craniofacial dystonia (HP:0012179)	1.77067680
92	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.76897230
93	Short femoral neck (HP:0100864)	1.76823864
94	Nephrogenic diabetes insipidus (HP:0009806)	1.76526394
95	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.74944983
96	Exertional dyspnea (HP:0002875)	1.73930257
97	Ketosis (HP:0001946)	1.72576099
98	Abnormality of renal resorption (HP:0011038)	1.71129252
99	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.70426082
100	Adrenal hypoplasia (HP:0000835)	1.69242945

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERN1	4.46835612
2	ADRBK2	3.00633912
3	BCKDK	2.91795063
4	TXK	2.74150125
5	PDK2	2.57777648
6	TIE1	2.49460968
7	MAP2K6	2.36381828
8	GRK1	2.30482665
9	WNK4	2.10140576
10	KDR	2.03619947
11	DYRK2	1.97306891
12	ZAK	1.68380365
13	MAP4K2	1.65346455
14	PIK3CA	1.64067317
15	PASK	1.58422415
16	NUAK1	1.54707193
17	TESK2	1.49168541
18	WNK3	1.46658996
19	LIMK1	1.40974134
20	BMPR1B	1.40881981
21	STK16	1.38186010
22	ADRBK1	1.32802387
23	PINK1	1.32279178
24	INSRR	1.31337949
25	TEC	1.26481892
26	CASK	1.22959336
27	FRK	1.22861608
28	MAP3K11	1.20419567
29	PRKCH	1.18937514
30	MAP2K7	1.18478210
31	MUSK	1.18015486
32	TLK1	1.10076945
33	LCK	1.08737435
34	AURKA	1.08494360
35	GRK7	1.08434189
36	EPHB2	1.05727871
37	LRRK2	1.04973080
38	MAP4K1	1.03793694
39	PKN1	1.01829144
40	EPHA4	1.01786447
41	VRK2	1.01506315
42	PRKCQ	0.98302789
43	SYK	0.96198813
44	NTRK2	0.94908034
45	ITK	0.94548537
46	STK39	0.92512817
47	AKT2	0.91973018
48	OBSCN	0.91221136
49	DYRK1B	0.89840171
50	PRKCG	0.81498158
51	NME2	0.77887722
52	NEK2	0.77661482
53	PRKACA	0.76990792
54	RPS6KA6	0.75844664
55	TGFBR1	0.75455360
56	MAP2K2	0.74744882
57	ABL2	0.74176617
58	EPHA3	0.73809247
59	VRK1	0.72941277
60	MAPK15	0.71868153
61	PIM1	0.71867436
62	CDK19	0.71862200
63	MAPK13	0.71632920
64	MAP2K4	0.71133265
65	CSNK2A2	0.70796042
66	STK3	0.70795670
67	TNK2	0.70526460
68	TAOK3	0.66785156
69	CSNK2A1	0.66310507
70	CAMK2A	0.65594307
71	PRKCA	0.64539180
72	MINK1	0.57926291
73	CDC7	0.56741969
74	TYRO3	0.56641896
75	DAPK3	0.56499084
76	OXSR1	0.56358771
77	IKBKE	0.55529467
78	BTK	0.54813269
79	PLK4	0.54552435
80	RPS6KC1	0.53227218
81	RPS6KL1	0.53227218
82	ATR	0.51349554
83	GRK5	0.51345248
84	CAMK1	0.50762797
85	FES	0.50026575
86	BRAF	0.49594596
87	PIK3CG	0.47122121
88	CSNK1A1	0.46600343
89	MAP3K6	0.46167890
90	PRKCD	0.45987912
91	NEK1	0.45983418
92	PRKD2	0.45513561
93	ROCK1	0.44632941
94	RPS6KB1	0.43778583
95	RPS6KA5	0.43006414
96	PLK1	0.42418219
97	INSR	0.41097526
98	DAPK2	0.39575974
99	CSNK1G3	0.37857664
100	PIM2	0.37622059

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.11664838
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.71886557
3	Parkinsons disease_Homo sapiens_hsa05012	3.22755535
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.59682525
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.49736531
6	Alzheimers disease_Homo sapiens_hsa05010	2.27632140
7	Huntingtons disease_Homo sapiens_hsa05016	2.15509531
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.13333588
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.05743140
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.02396418
11	Proteasome_Homo sapiens_hsa03050	1.99237373
12	Sulfur metabolism_Homo sapiens_hsa00920	1.95503859
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.94226548
14	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.87380582
15	RNA polymerase_Homo sapiens_hsa03020	1.81602188
16	Phototransduction_Homo sapiens_hsa04744	1.74338101
17	RNA degradation_Homo sapiens_hsa03018	1.66412326
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.61600909
19	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.55638554
20	Allograft rejection_Homo sapiens_hsa05330	1.55419398
21	Protein export_Homo sapiens_hsa03060	1.49526734
22	Graft-versus-host disease_Homo sapiens_hsa05332	1.41304554
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.36093284
24	Olfactory transduction_Homo sapiens_hsa04740	1.23179235
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.20388216
26	Propanoate metabolism_Homo sapiens_hsa00640	1.18742679
27	Asthma_Homo sapiens_hsa05310	1.18172606
28	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.15061421
29	Butanoate metabolism_Homo sapiens_hsa00650	1.12415799
30	Type I diabetes mellitus_Homo sapiens_hsa04940	1.11464869
31	Sulfur relay system_Homo sapiens_hsa04122	1.06670421
32	Nicotine addiction_Homo sapiens_hsa05033	1.05556964
33	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.05534204
34	Regulation of autophagy_Homo sapiens_hsa04140	1.05492834
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.04792064
36	Caffeine metabolism_Homo sapiens_hsa00232	1.03457927
37	Basal transcription factors_Homo sapiens_hsa03022	1.02843432
38	Peroxisome_Homo sapiens_hsa04146	1.02368963
39	Ether lipid metabolism_Homo sapiens_hsa00565	1.00332555
40	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.99242216
41	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.98845101
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.98189099
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.92224346
44	Tryptophan metabolism_Homo sapiens_hsa00380	0.90921107
45	Retinol metabolism_Homo sapiens_hsa00830	0.87262139
46	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.85487515
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.85296067
48	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.83786997
49	Homologous recombination_Homo sapiens_hsa03440	0.79098058
50	Pyrimidine metabolism_Homo sapiens_hsa00240	0.78801784
51	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.76539596
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.76178518
53	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.74941580
54	Basal cell carcinoma_Homo sapiens_hsa05217	0.73516192
55	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.70209909
56	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.69163794
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68847711
58	Taste transduction_Homo sapiens_hsa04742	0.67124003
59	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.66230891
60	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.65461885
61	Antigen processing and presentation_Homo sapiens_hsa04612	0.65277438
62	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.65202370
63	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.63955077
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.63660606
65	Purine metabolism_Homo sapiens_hsa00230	0.62051356
66	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.61633450
67	Selenocompound metabolism_Homo sapiens_hsa00450	0.61238384
68	Steroid biosynthesis_Homo sapiens_hsa00100	0.60221895
69	Morphine addiction_Homo sapiens_hsa05032	0.59657704
70	Metabolic pathways_Homo sapiens_hsa01100	0.56761522
71	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54508174
72	Collecting duct acid secretion_Homo sapiens_hsa04966	0.54112632
73	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.52837220
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.51468245
75	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.49601841
76	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.48519482
77	GABAergic synapse_Homo sapiens_hsa04727	0.47948732
78	Fanconi anemia pathway_Homo sapiens_hsa03460	0.47139753
79	Rheumatoid arthritis_Homo sapiens_hsa05323	0.45818542
80	Serotonergic synapse_Homo sapiens_hsa04726	0.45206760
81	One carbon pool by folate_Homo sapiens_hsa00670	0.44553536
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43568939
83	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.40128276
84	Insulin secretion_Homo sapiens_hsa04911	0.38175593
85	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.36887554
86	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.36207438
87	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.34432778
88	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.33971128
89	Malaria_Homo sapiens_hsa05144	0.33539368
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.31667123
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.28628911
92	Nucleotide excision repair_Homo sapiens_hsa03420	0.26753406
93	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.24103656
94	Circadian entrainment_Homo sapiens_hsa04713	0.23745820
95	Mismatch repair_Homo sapiens_hsa03430	0.22639546
96	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.21037015
97	Cholinergic synapse_Homo sapiens_hsa04725	0.20700315
98	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.20006108
99	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.18530471
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.18277318

RPS20P14

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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