ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cullin deneddylation (GO:0010388)	5.67318027
2	regulation of meiosis I (GO:0060631)	5.25623269
3	retinal cone cell development (GO:0046549)	4.94659003
4	protein deneddylation (GO:0000338)	4.66269457
5	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.63271343
6	histone H3-K36 demethylation (GO:0070544)	4.54680452
7	DNA double-strand break processing (GO:0000729)	4.47661573
8	replication fork processing (GO:0031297)	4.36650361
9	protein K6-linked ubiquitination (GO:0085020)	4.30367148
10	synapsis (GO:0007129)	4.30323999
11	DNA catabolic process, exonucleolytic (GO:0000738)	3.96199930
12	cornea development in camera-type eye (GO:0061303)	3.92727247
13	response to X-ray (GO:0010165)	3.81881927
14	signal peptide processing (GO:0006465)	3.58182708
15	indolalkylamine metabolic process (GO:0006586)	3.46770852
16	GTP biosynthetic process (GO:0006183)	3.40533192
17	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.37280435
18	regulation of mitotic spindle checkpoint (GO:1903504)	3.37280435
19	double-strand break repair via homologous recombination (GO:0000724)	3.36270160
20	recombinational repair (GO:0000725)	3.32637307
21	neural tube formation (GO:0001841)	3.31943545
22	intraciliary transport (GO:0042073)	3.27312494
23	L-fucose catabolic process (GO:0042355)	3.26521148
24	fucose catabolic process (GO:0019317)	3.26521148
25	L-fucose metabolic process (GO:0042354)	3.26521148
26	male meiosis (GO:0007140)	3.25587136
27	protein K11-linked deubiquitination (GO:0035871)	3.25548829
28	regulation of mitotic spindle organization (GO:0060236)	3.23389713
29	axoneme assembly (GO:0035082)	3.22422001
30	glial cell proliferation (GO:0014009)	3.21593488
31	limb bud formation (GO:0060174)	3.20696048
32	CTP metabolic process (GO:0046036)	3.20105203
33	CTP biosynthetic process (GO:0006241)	3.20105203
34	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.19794696
35	mitotic sister chromatid cohesion (GO:0007064)	3.12969920
36	determination of adult lifespan (GO:0008340)	3.09485516
37	retinal rod cell development (GO:0046548)	3.06047999
38	male meiosis I (GO:0007141)	3.02426463
39	reciprocal DNA recombination (GO:0035825)	3.02074881
40	reciprocal meiotic recombination (GO:0007131)	3.02074881
41	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	3.01511448
42	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.98075868
43	regulation of timing of cell differentiation (GO:0048505)	2.96834605
44	lactate metabolic process (GO:0006089)	2.94350500
45	sympathetic nervous system development (GO:0048485)	2.93185538
46	DNA ligation (GO:0006266)	2.92312809
47	anterograde synaptic vesicle transport (GO:0048490)	2.90056322
48	meiosis I (GO:0007127)	2.88455341
49	establishment of protein localization to Golgi (GO:0072600)	2.88063932
50	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.86361036
51	intra-S DNA damage checkpoint (GO:0031573)	2.85423632
52	histamine secretion (GO:0001821)	2.85312372
53	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.84606278
54	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.84504319
55	regulation of translation, ncRNA-mediated (GO:0045974)	2.84504319
56	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.84504319
57	preassembly of GPI anchor in ER membrane (GO:0016254)	2.83983970
58	DNA synthesis involved in DNA repair (GO:0000731)	2.82044480
59	sister chromatid cohesion (GO:0007062)	2.81589717
60	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.81395443
61	isotype switching (GO:0045190)	2.81395443
62	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.81395443
63	peptidyl-histidine modification (GO:0018202)	2.80575535
64	proteasome assembly (GO:0043248)	2.79427964
65	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.79381546
66	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.79235917
67	auditory receptor cell stereocilium organization (GO:0060088)	2.78950703
68	attachment of spindle microtubules to kinetochore (GO:0008608)	2.78505846
69	centriole replication (GO:0007099)	2.77980484
70	multicellular organismal aging (GO:0010259)	2.76786222
71	glycosphingolipid biosynthetic process (GO:0006688)	2.76494709
72	regulation of translation in response to stress (GO:0043555)	2.76337791
73	protein targeting to Golgi (GO:0000042)	2.75649571
74	keratinocyte development (GO:0003334)	2.71762702
75	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.70858750
76	UTP biosynthetic process (GO:0006228)	2.70774411
77	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.70343669
78	microtubule anchoring (GO:0034453)	2.68914623
79	regulation of hippo signaling (GO:0035330)	2.66857561
80	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.65407810
81	positive regulation of tolerance induction (GO:0002645)	2.63740690
82	tryptophan catabolic process (GO:0006569)	2.63436229
83	indole-containing compound catabolic process (GO:0042436)	2.63436229
84	indolalkylamine catabolic process (GO:0046218)	2.63436229
85	kinetochore assembly (GO:0051382)	2.63355068
86	regulation of T cell tolerance induction (GO:0002664)	2.62477469
87	chromatin remodeling at centromere (GO:0031055)	2.61705088
88	cilium or flagellum-dependent cell motility (GO:0001539)	2.59426546
89	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.58727836
90	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.57907036
91	response to pheromone (GO:0019236)	2.57184251
92	C-terminal protein lipidation (GO:0006501)	2.56541170
93	piRNA metabolic process (GO:0034587)	2.56251357
94	negative regulation of cAMP-mediated signaling (GO:0043951)	2.56200871
95	GPI anchor metabolic process (GO:0006505)	2.54230443
96	negative regulation of DNA recombination (GO:0045910)	2.53044552
97	regulation of spindle organization (GO:0090224)	2.52668503
98	meiotic nuclear division (GO:0007126)	2.52114913
99	protein K63-linked deubiquitination (GO:0070536)	2.50894832
100	cilium movement (GO:0003341)	2.50892440

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.97639631
2	FLI1_27457419_Chip-Seq_LIVER_Mouse	3.49762427
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.21328789
4	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.97802804
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.84353098
6	VDR_22108803_ChIP-Seq_LS180_Human	2.67332351
7	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.66892713
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.65887509
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.58996501
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.50999784
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.43828371
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.37637727
13	EWS_26573619_Chip-Seq_HEK293_Human	2.33683873
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.32537858
15	FUS_26573619_Chip-Seq_HEK293_Human	2.31260494
16	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.29392251
17	PCGF2_27294783_Chip-Seq_NPCs_Mouse	2.07077096
18	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.02212893
19	P300_19829295_ChIP-Seq_ESCs_Human	1.98070888
20	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.89246562
21	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.87343553
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.81923398
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.81819905
24	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.81141489
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.81087072
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.74678378
27	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.73936199
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.72869911
29	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.68736033
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.65268172
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.61882007
32	TAF15_26573619_Chip-Seq_HEK293_Human	1.61536408
33	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.59952798
34	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.59642573
35	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.59075826
36	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.56369377
37	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.55832658
38	AR_21572438_ChIP-Seq_LNCaP_Human	1.53692702
39	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.52242959
40	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.51743082
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50563096
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.50368528
43	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.50040287
44	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.49484011
45	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.47951083
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45572151
47	ER_23166858_ChIP-Seq_MCF-7_Human	1.40930720
48	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.40901655
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40130493
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.40130493
51	TCF4_22108803_ChIP-Seq_LS180_Human	1.37861067
52	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.37545592
53	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.36461560
54	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.35004411
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34789214
56	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.34670630
57	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.34485600
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34330897
59	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.34061110
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.33837534
61	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31280811
62	AR_25329375_ChIP-Seq_VCAP_Human	1.30887002
63	P300_18555785_Chip-Seq_ESCs_Mouse	1.30693538
64	STAT3_23295773_ChIP-Seq_U87_Human	1.30245098
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.30093415
66	VDR_23849224_ChIP-Seq_CD4+_Human	1.30024027
67	P53_22387025_ChIP-Seq_ESCs_Mouse	1.28517193
68	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.28298404
69	TCF4_23295773_ChIP-Seq_U87_Human	1.26943798
70	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.26229117
71	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.25602474
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25061485
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25061485
74	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.24135265
75	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.24119305
76	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.23559399
77	MYC_18940864_ChIP-ChIP_HL60_Human	1.22540643
78	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.19021704
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18958842
80	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.17717690
81	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16848321
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16490756
83	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.15824362
84	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15770393
85	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14960084
86	CDX2_22108803_ChIP-Seq_LS180_Human	1.13478503
87	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.12186574
88	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.12116376
89	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.10621724
90	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.09455898
91	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.09131814
92	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.08421094
93	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.08358525
94	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.08192661
95	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.06670468
96	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.06403424
97	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.06274569
98	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.05202403
99	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.05199841
100	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.02964119

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.93050381
2	MP0005645_abnormal_hypothalamus_physiol	3.76045264
3	MP0008058_abnormal_DNA_repair	3.59492984
4	MP0008995_early_reproductive_senescence	3.48251151
5	MP0003786_premature_aging	3.40194051
6	MP0008877_abnormal_DNA_methylation	3.20268411
7	MP0003646_muscle_fatigue	2.61459555
8	MP0000427_abnormal_hair_cycle	2.49147129
9	MP0000569_abnormal_digit_pigmentation	2.43869986
10	MP0008007_abnormal_cellular_replicative	2.43236102
11	MP0010094_abnormal_chromosome_stability	2.36046729
12	MP0000372_irregular_coat_pigmentation	2.34539604
13	MP0005075_abnormal_melanosome_morpholog	2.30791099
14	MP0002160_abnormal_reproductive_system	2.20267382
15	MP0003950_abnormal_plasma_membrane	1.87701022
16	MP0002282_abnormal_trachea_morphology	1.87642942
17	MP0003718_maternal_effect	1.83061214
18	MP0001835_abnormal_antigen_presentation	1.75831599
19	MP0005253_abnormal_eye_physiology	1.74998872
20	MP0000647_abnormal_sebaceous_gland	1.74967727
21	MP0002751_abnormal_autonomic_nervous	1.73883437
22	MP0006072_abnormal_retinal_apoptosis	1.72073387
23	MP0005551_abnormal_eye_electrophysiolog	1.71123166
24	MP0008775_abnormal_heart_ventricle	1.69429773
25	MP0008057_abnormal_DNA_replication	1.57234290
26	MP0001501_abnormal_sleep_pattern	1.50156330
27	MP0008789_abnormal_olfactory_epithelium	1.49771253
28	MP0003195_calcinosis	1.48978276
29	MP0009697_abnormal_copulation	1.45830699
30	MP0008872_abnormal_physiological_respon	1.43680105
31	MP0005395_other_phenotype	1.42565650
32	MP0004043_abnormal_pH_regulation	1.40726671
33	MP0005389_reproductive_system_phenotype	1.38953834
34	MP0002736_abnormal_nociception_after	1.36159906
35	MP0002876_abnormal_thyroid_physiology	1.35578788
36	MP0002168_other_aberrant_phenotype	1.35417057
37	MP0002095_abnormal_skin_pigmentation	1.34625716
38	MP0009046_muscle_twitch	1.32147166
39	MP0004381_abnormal_hair_follicle	1.31829558
40	MP0004484_altered_response_of	1.25798969
41	MP0001502_abnormal_circadian_rhythm	1.24619602
42	MP0002233_abnormal_nose_morphology	1.20545514
43	MP0010352_gastrointestinal_tract_polyps	1.19240445
44	MP0003186_abnormal_redox_activity	1.18854084
45	MP0002234_abnormal_pharynx_morphology	1.16198780
46	MP0002210_abnormal_sex_determination	1.14576555
47	MP0003011_delayed_dark_adaptation	1.11150534
48	MP0001929_abnormal_gametogenesis	1.10827972
49	MP0008932_abnormal_embryonic_tissue	1.10571498
50	MP0010307_abnormal_tumor_latency	1.08615490
51	MP0009764_decreased_sensitivity_to	1.08451112
52	MP0005187_abnormal_penis_morphology	1.04389609
53	MP0003045_fibrosis	1.01927838
54	MP0002272_abnormal_nervous_system	1.00203163
55	MP0001919_abnormal_reproductive_system	0.99356412
56	MP0003787_abnormal_imprinting	0.99341571
57	MP0002090_abnormal_vision	0.99032908
58	MP0001119_abnormal_female_reproductive	0.95350918
59	MP0002254_reproductive_system_inflammat	0.93904038
60	MP0005408_hypopigmentation	0.93682851
61	MP0001984_abnormal_olfaction	0.91806229
62	MP0000383_abnormal_hair_follicle	0.91652184
63	MP0001486_abnormal_startle_reflex	0.91650576
64	MP0003077_abnormal_cell_cycle	0.91390632
65	MP0005499_abnormal_olfactory_system	0.91276897
66	MP0005394_taste/olfaction_phenotype	0.91276897
67	MP0009785_altered_susceptibility_to	0.90977651
68	MP0000653_abnormal_sex_gland	0.90745260
69	MP0003755_abnormal_palate_morphology	0.89946520
70	MP0005171_absent_coat_pigmentation	0.89593246
71	MP0005367_renal/urinary_system_phenotyp	0.88767913
72	MP0000516_abnormal_urinary_system	0.88767913
73	MP0001145_abnormal_male_reproductive	0.87197124
74	MP0000631_abnormal_neuroendocrine_gland	0.84034251
75	MP0003121_genomic_imprinting	0.83186305
76	MP0003937_abnormal_limbs/digits/tail_de	0.80796145
77	MP0002693_abnormal_pancreas_physiology	0.78062548
78	MP0002277_abnormal_respiratory_mucosa	0.76027372
79	MP0001299_abnormal_eye_distance/	0.74567658
80	MP0004885_abnormal_endolymph	0.74282918
81	MP0003698_abnormal_male_reproductive	0.71640624
82	MP0005360_urolithiasis	0.70243249
83	MP0000015_abnormal_ear_pigmentation	0.69176614
84	MP0002166_altered_tumor_susceptibility	0.68378759
85	MP0009745_abnormal_behavioral_response	0.68242460
86	MP0000778_abnormal_nervous_system	0.67823388
87	MP0005646_abnormal_pituitary_gland	0.66886728
88	MP0002177_abnormal_outer_ear	0.66305154
89	MP0003111_abnormal_nucleus_morphology	0.66256063
90	MP0006276_abnormal_autonomic_nervous	0.63494654
91	MP0001177_atelectasis	0.61847491
92	MP0003567_abnormal_fetal_cardiomyocyte	0.61394052
93	MP0006035_abnormal_mitochondrial_morpho	0.61120056
94	MP0002638_abnormal_pupillary_reflex	0.60755098
95	MP0001529_abnormal_vocalization	0.60544523
96	MP0004233_abnormal_muscle_weight	0.58622264
97	MP0003890_abnormal_embryonic-extraembry	0.57084532
98	MP0004142_abnormal_muscle_tone	0.57033721
99	MP0001968_abnormal_touch/_nociception	0.56394871
100	MP0006036_abnormal_mitochondrial_physio	0.54884841

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Optic neuritis (HP:0100653)	5.61248510
2	Retrobulbar optic neuritis (HP:0100654)	5.61248510
3	Tetraparesis (HP:0002273)	4.88614042
4	Orchitis (HP:0100796)	4.71286261
5	Keratoconjunctivitis sicca (HP:0001097)	3.88110423
6	Keratoconjunctivitis (HP:0001096)	3.81341926
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.79756094
8	Absent/shortened dynein arms (HP:0200106)	3.79756094
9	Myositis (HP:0100614)	3.66252866
10	Hemoptysis (HP:0002105)	3.52361134
11	Hypothermia (HP:0002045)	3.06534580
12	Abnormal ciliary motility (HP:0012262)	3.02021494
13	Congenital stationary night blindness (HP:0007642)	2.98808229
14	Tubulointerstitial fibrosis (HP:0005576)	2.97102672
15	Abnormality of chromosome stability (HP:0003220)	2.96832542
16	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.91128355
17	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.85576392
18	Abnormal respiratory motile cilium morphology (HP:0005938)	2.72825580
19	Abnormal respiratory epithelium morphology (HP:0012253)	2.72825580
20	Upper motor neuron abnormality (HP:0002127)	2.66209066
21	Upper limb muscle weakness (HP:0003484)	2.59073375
22	Abnormality of midbrain morphology (HP:0002418)	2.51275848
23	Molar tooth sign on MRI (HP:0002419)	2.51275848
24	Febrile seizures (HP:0002373)	2.51037255
25	Arterial thrombosis (HP:0004420)	2.49693566
26	Portal hypertension (HP:0001409)	2.45545091
27	Volvulus (HP:0002580)	2.44570129
28	Meckel diverticulum (HP:0002245)	2.43939032
29	Acute necrotizing encephalopathy (HP:0006965)	2.39170255
30	Abnormality of the ileum (HP:0001549)	2.38033843
31	Paresthesia (HP:0003401)	2.35965824
32	Horizontal nystagmus (HP:0000666)	2.34216040
33	Focal motor seizures (HP:0011153)	2.30135553
34	Chromsome breakage (HP:0040012)	2.27475112
35	Constricted visual fields (HP:0001133)	2.27216700
36	Colon cancer (HP:0003003)	2.25862652
37	Hypoproteinemia (HP:0003075)	2.24782486
38	Oligodactyly (hands) (HP:0001180)	2.23230900
39	Abnormal respiratory motile cilium physiology (HP:0012261)	2.22134175
40	Abnormality of the hepatic vasculature (HP:0006707)	2.21222150
41	Glomerulopathy (HP:0100820)	2.20518316
42	Gangrene (HP:0100758)	2.18086586
43	Thyroiditis (HP:0100646)	2.16296492
44	Abnormality of the preputium (HP:0100587)	2.15765448
45	Ectopic kidney (HP:0000086)	2.14303981
46	Abnormality of the labia minora (HP:0012880)	2.09416279
47	Abnormality of the pericardium (HP:0001697)	2.09227266
48	Anorexia (HP:0002039)	2.08385474
49	Neoplasm of the colon (HP:0100273)	2.07555005
50	Tubulointerstitial abnormality (HP:0001969)	2.07133652
51	Pulmonary infiltrates (HP:0002113)	2.02994155
52	Erectile abnormalities (HP:0100639)	2.00054611
53	Acute encephalopathy (HP:0006846)	1.96152874
54	Clubbing of toes (HP:0100760)	1.95724419
55	Ependymoma (HP:0002888)	1.94895777
56	Septo-optic dysplasia (HP:0100842)	1.94640326
57	Progressive macrocephaly (HP:0004481)	1.94433675
58	Abnormality of the pleura (HP:0002103)	1.94108695
59	Keratitis (HP:0000491)	1.91033872
60	Increased CSF lactate (HP:0002490)	1.91009836
61	Abnormality of the prostate (HP:0008775)	1.89812413
62	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.89384958
63	Abnormal mitochondria in muscle tissue (HP:0008316)	1.88904707
64	Vasculitis (HP:0002633)	1.88051114
65	Polyneuropathy (HP:0001271)	1.84984274
66	Gonadotropin excess (HP:0000837)	1.84255258
67	Esophageal varix (HP:0002040)	1.84002962
68	Severe visual impairment (HP:0001141)	1.81144606
69	Abnormal hair whorl (HP:0010721)	1.81009066
70	Duodenal stenosis (HP:0100867)	1.80449456
71	Small intestinal stenosis (HP:0012848)	1.80449456
72	Abnormality of the pancreatic islet cells (HP:0006476)	1.79847247
73	Abnormality of endocrine pancreas physiology (HP:0012093)	1.79847247
74	Optic disc pallor (HP:0000543)	1.79673209
75	Bifid uvula (HP:0000193)	1.79292209
76	Optic nerve hypoplasia (HP:0000609)	1.79283433
77	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.78731954
78	Glioma (HP:0009733)	1.78493005
79	Pancreatic cysts (HP:0001737)	1.76766366
80	Encephalitis (HP:0002383)	1.76416369
81	2-3 toe syndactyly (HP:0004691)	1.74302335
82	Absent speech (HP:0001344)	1.74057864
83	Astigmatism (HP:0000483)	1.73751269
84	Joint swelling (HP:0001386)	1.73300714
85	Dyschromatopsia (HP:0007641)	1.71894729
86	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.70031738
87	Abnormality of the renal cortex (HP:0011035)	1.69703273
88	Hypokalemic alkalosis (HP:0001949)	1.69549527
89	Exotropia (HP:0000577)	1.69384895
90	Abnormal rod and cone electroretinograms (HP:0008323)	1.69004831
91	Cupped ear (HP:0000378)	1.68714870
92	Severe combined immunodeficiency (HP:0004430)	1.68651115
93	Chronic hepatic failure (HP:0100626)	1.66390430
94	Short tibia (HP:0005736)	1.66115537
95	Hyperventilation (HP:0002883)	1.65847351
96	Ascites (HP:0001541)	1.64512579
97	True hermaphroditism (HP:0010459)	1.61797604
98	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.60889777
99	Eosinophilia (HP:0001880)	1.60658343
100	Ketoacidosis (HP:0001993)	1.60157491

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP2K6	5.02876351
2	FRK	2.83228432
3	ZAK	2.67521809
4	EIF2AK3	2.63980492
5	MAP4K2	2.62597926
6	WNK3	2.60119070
7	NUAK1	2.57844961
8	WEE1	2.38762456
9	NLK	2.32994129
10	PNCK	2.29563912
11	EPHA3	2.28413155
12	BCR	2.17882768
13	MST4	2.12934074
14	EIF2AK1	2.12545035
15	TGFBR2	2.08428280
16	OXSR1	2.07973763
17	TRIM28	2.06474674
18	STK38L	2.03938093
19	AKT3	2.03032976
20	TNIK	2.02089862
21	MKNK2	1.96635698
22	STK39	1.70265700
23	PLK3	1.67051274
24	GRK1	1.51234651
25	MAPK13	1.36653450
26	PLK2	1.33216780
27	BRSK2	1.32642526
28	MAP3K12	1.27707020
29	ERBB3	1.24382198
30	NEK1	1.23611505
31	BMPR1B	1.22594003
32	FER	1.20153501
33	TTK	1.18648838
34	PLK4	1.17247027
35	MAP3K4	1.16639421
36	TSSK6	1.16407620
37	BUB1	1.08604269
38	PKN1	1.01609304
39	VRK1	0.90305780
40	MINK1	0.87301498
41	CASK	0.86693818
42	CDK8	0.85685320
43	INSRR	0.85322993
44	PAK3	0.84248485
45	PRKCE	0.83383715
46	DYRK2	0.83294369
47	MKNK1	0.79843997
48	CSNK1G1	0.79166472
49	MELK	0.75474326
50	FGFR1	0.75035079
51	CDK9	0.74595844
52	CHEK2	0.71711954
53	CSNK1A1L	0.67936063
54	CSNK1G3	0.66736214
55	CDK19	0.65900818
56	PLK1	0.65656374
57	BCKDK	0.61181664
58	TIE1	0.58286891
59	CAMK1G	0.58163611
60	ATM	0.56767081
61	ATR	0.56228119
62	CDK3	0.55305104
63	PRKCG	0.53104723
64	ADRBK2	0.52755270
65	CSNK1G2	0.52547376
66	PTK2B	0.50030396
67	EGFR	0.48852736
68	GRK5	0.47579600
69	MAP3K14	0.47077860
70	CAMK2D	0.46663454
71	BMPR2	0.46640446
72	VRK2	0.46548191
73	ACVR1B	0.45385282
74	EIF2AK2	0.44413813
75	SGK2	0.39847261
76	CAMK1	0.39594064
77	CAMK2A	0.38017891
78	ITK	0.36581041
79	ERBB2	0.36098964
80	PASK	0.36001449
81	PINK1	0.35916961
82	TAF1	0.35463382
83	CAMKK2	0.34679523
84	CHEK1	0.33635997
85	CSNK1D	0.32407358
86	FGFR3	0.32378302
87	STK16	0.32240354
88	ROCK1	0.32103107
89	MYLK	0.30306248
90	TGFBR1	0.30249452
91	IGF1R	0.29400570
92	PRKCQ	0.29200184
93	JAK1	0.27564645
94	IRAK1	0.26621649
95	STK11	0.26155930
96	CSNK1A1	0.26012409
97	CAMK2B	0.24395955
98	ADRBK1	0.24311544
99	TEC	0.24015102
100	CSNK2A1	0.23962545

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	4.29118263
2	Non-homologous end-joining_Homo sapiens_hsa03450	3.73020928
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.65994707
4	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.26158577
5	Proteasome_Homo sapiens_hsa03050	3.03210777
6	RNA polymerase_Homo sapiens_hsa03020	2.82962615
7	Asthma_Homo sapiens_hsa05310	2.46798276
8	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.30199172
9	Allograft rejection_Homo sapiens_hsa05330	1.98922890
10	Nitrogen metabolism_Homo sapiens_hsa00910	1.95575463
11	Homologous recombination_Homo sapiens_hsa03440	1.87423190
12	Fanconi anemia pathway_Homo sapiens_hsa03460	1.85249031
13	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.85099791
14	Graft-versus-host disease_Homo sapiens_hsa05332	1.82183796
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.79192517
16	Type I diabetes mellitus_Homo sapiens_hsa04940	1.75645722
17	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.74268897
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.73056002
19	One carbon pool by folate_Homo sapiens_hsa00670	1.63241409
20	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.62837927
21	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.61060760
22	Propanoate metabolism_Homo sapiens_hsa00640	1.54354093
23	Phototransduction_Homo sapiens_hsa04744	1.52074956
24	RNA degradation_Homo sapiens_hsa03018	1.46395144
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.42640652
26	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.41276503
27	Basal transcription factors_Homo sapiens_hsa03022	1.35674928
28	RNA transport_Homo sapiens_hsa03013	1.33482996
29	Oxidative phosphorylation_Homo sapiens_hsa00190	1.25408829
30	Butanoate metabolism_Homo sapiens_hsa00650	1.24524417
31	Circadian rhythm_Homo sapiens_hsa04710	1.24052987
32	Huntingtons disease_Homo sapiens_hsa05016	1.17900527
33	Parkinsons disease_Homo sapiens_hsa05012	1.15392761
34	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.13074564
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.08995663
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.07098581
37	Regulation of autophagy_Homo sapiens_hsa04140	1.06487870
38	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.03235335
39	Antigen processing and presentation_Homo sapiens_hsa04612	1.02451989
40	Steroid biosynthesis_Homo sapiens_hsa00100	0.98400209
41	Oocyte meiosis_Homo sapiens_hsa04114	0.96948662
42	Cell cycle_Homo sapiens_hsa04110	0.96381367
43	Taste transduction_Homo sapiens_hsa04742	0.93976247
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.93746069
45	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.88523276
46	Viral myocarditis_Homo sapiens_hsa05416	0.88120373
47	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.84533136
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.82051170
49	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.81540285
50	Mismatch repair_Homo sapiens_hsa03430	0.80165894
51	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.80030725
52	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.77756517
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.75090036
54	Lysine degradation_Homo sapiens_hsa00310	0.74731284
55	Rheumatoid arthritis_Homo sapiens_hsa05323	0.73311176
56	Fatty acid metabolism_Homo sapiens_hsa01212	0.71968504
57	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.68813749
58	p53 signaling pathway_Homo sapiens_hsa04115	0.68484002
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.68304809
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.68251434
61	Ether lipid metabolism_Homo sapiens_hsa00565	0.66603241
62	Olfactory transduction_Homo sapiens_hsa04740	0.64108897
63	Alzheimers disease_Homo sapiens_hsa05010	0.63814145
64	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.61849545
65	Purine metabolism_Homo sapiens_hsa00230	0.60845119
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60752398
67	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.59602303
68	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.58307537
69	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.58087116
70	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.57437975
71	Fatty acid degradation_Homo sapiens_hsa00071	0.55104594
72	Nicotine addiction_Homo sapiens_hsa05033	0.53888189
73	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.53445510
74	beta-Alanine metabolism_Homo sapiens_hsa00410	0.53356604
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.52623843
76	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50917723
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50453128
78	Basal cell carcinoma_Homo sapiens_hsa05217	0.49975940
79	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.49315611
80	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.49205780
81	Metabolic pathways_Homo sapiens_hsa01100	0.45495907
82	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.45482700
83	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.45431388
84	Retinol metabolism_Homo sapiens_hsa00830	0.45054155
85	Pyruvate metabolism_Homo sapiens_hsa00620	0.44331389
86	Base excision repair_Homo sapiens_hsa03410	0.43935348
87	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.40728817
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.39764972
89	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.38503546
90	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.37772397
91	Peroxisome_Homo sapiens_hsa04146	0.37321619
92	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.36810987
93	Glycerolipid metabolism_Homo sapiens_hsa00561	0.36707718
94	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.36499223
95	Caffeine metabolism_Homo sapiens_hsa00232	0.35320029
96	Nucleotide excision repair_Homo sapiens_hsa03420	0.34293758
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.28756879
98	Selenocompound metabolism_Homo sapiens_hsa00450	0.26239400
99	Hippo signaling pathway_Homo sapiens_hsa04390	0.26164785
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.23961626

RPS20P15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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