RPS20P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)7.92126355
2ribosomal small subunit assembly (GO:0000028)7.60005565
3viral transcription (GO:0019083)6.75010595
4ribosomal small subunit biogenesis (GO:0042274)6.49162850
5translational termination (GO:0006415)6.48761539
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.46921496
7cotranslational protein targeting to membrane (GO:0006613)5.42742022
8translational elongation (GO:0006414)5.37845656
9protein targeting to ER (GO:0045047)5.36266654
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.17448742
11protein localization to endoplasmic reticulum (GO:0070972)5.06199208
12viral life cycle (GO:0019058)4.97808457
13cellular protein complex disassembly (GO:0043624)4.97512917
14protein neddylation (GO:0045116)4.90689374
15behavioral response to nicotine (GO:0035095)4.89569245
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.75725772
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.66180044
18chaperone-mediated protein transport (GO:0072321)4.62835631
19protein complex disassembly (GO:0043241)4.18965926
20cell proliferation in forebrain (GO:0021846)4.09960353
21ATP synthesis coupled proton transport (GO:0015986)4.01070807
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.01070807
23macromolecular complex disassembly (GO:0032984)3.97970266
24ribosomal large subunit biogenesis (GO:0042273)3.97270201
25translational initiation (GO:0006413)3.96585269
26regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.84361909
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.74013748
28NADH dehydrogenase complex assembly (GO:0010257)3.74013748
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.74013748
30protein complex biogenesis (GO:0070271)3.66894840
31protein targeting to membrane (GO:0006612)3.56779326
32mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.51278304
33pyrimidine nucleobase catabolic process (GO:0006208)3.51220982
34nonmotile primary cilium assembly (GO:0035058)3.50633395
35neuron fate determination (GO:0048664)3.46681640
36positive regulation of T cell apoptotic process (GO:0070234)3.44248537
37nuclear-transcribed mRNA catabolic process (GO:0000956)3.38098729
38epithelial cilium movement (GO:0003351)3.37254328
39establishment of mitochondrion localization (GO:0051654)3.32910326
40pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.29436156
41translation (GO:0006412)3.28565444
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.27718872
43exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.20100144
44mRNA catabolic process (GO:0006402)3.18955187
45mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.18641751
46mitochondrial respiratory chain complex assembly (GO:0033108)3.17259180
47mitochondrion transport along microtubule (GO:0047497)3.13965391
48establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.13965391
49establishment of protein localization to mitochondrial membrane (GO:0090151)3.13655523
50ncRNA 3-end processing (GO:0043628)3.11372014
51synaptic transmission, cholinergic (GO:0007271)3.09986332
52cellular component biogenesis (GO:0044085)3.07536317
53cardiovascular system development (GO:0072358)3.07494648
54short-term memory (GO:0007614)3.00905729
55somite development (GO:0061053)2.98070538
56pattern specification involved in kidney development (GO:0061004)2.97787255
57positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.96505898
58ribonucleoprotein complex biogenesis (GO:0022613)2.94460441
59motile cilium assembly (GO:0044458)2.94259284
60dendritic spine morphogenesis (GO:0060997)2.90806601
61substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.87565046
62substrate-independent telencephalic tangential migration (GO:0021826)2.87565046
63electron transport chain (GO:0022900)2.84244752
64nucleobase catabolic process (GO:0046113)2.83318511
65respiratory electron transport chain (GO:0022904)2.83117978
66L-serine metabolic process (GO:0006563)2.82968152
67rRNA catabolic process (GO:0016075)2.80377498
68RNA catabolic process (GO:0006401)2.80212125
69intraciliary transport (GO:0042073)2.79924040
70viral protein processing (GO:0019082)2.78540603
71pyrimidine nucleotide catabolic process (GO:0006244)2.75830619
72nephron tubule morphogenesis (GO:0072078)2.74118311
73nephron epithelium morphogenesis (GO:0072088)2.74118311
74ubiquinone biosynthetic process (GO:0006744)2.71474836
75body morphogenesis (GO:0010171)2.69833008
76protein polyglutamylation (GO:0018095)2.69728142
77hypothalamus development (GO:0021854)2.69200403
78tongue development (GO:0043586)2.66100131
79cilium movement (GO:0003341)2.65545378
80axon ensheathment in central nervous system (GO:0032291)2.63228987
81central nervous system myelination (GO:0022010)2.63228987
82regulation of non-canonical Wnt signaling pathway (GO:2000050)2.61739048
83cornea development in camera-type eye (GO:0061303)2.61631566
84tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59733419
85RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59733419
86axoneme assembly (GO:0035082)2.59607682
87seminiferous tubule development (GO:0072520)2.59284660
88retinal ganglion cell axon guidance (GO:0031290)2.58405491
89negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.58286930
90axonal fasciculation (GO:0007413)2.56983385
91cellular ketone body metabolic process (GO:0046950)2.55576541
92water-soluble vitamin biosynthetic process (GO:0042364)2.55135363
93negative regulation of appetite (GO:0032099)2.53506533
94negative regulation of response to food (GO:0032096)2.53506533
95piRNA metabolic process (GO:0034587)2.50200685
96hydrogen ion transmembrane transport (GO:1902600)2.50156569
97protein peptidyl-prolyl isomerization (GO:0000413)2.48637452
98positive regulation of digestive system process (GO:0060456)2.46603095
99ubiquinone metabolic process (GO:0006743)2.46500239
100establishment of protein localization to membrane (GO:0090150)2.46306069

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.34675865
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.02059687
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.39480384
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.99589996
5CBX2_27304074_Chip-Seq_ESCs_Mouse2.51810330
6ZNF274_21170338_ChIP-Seq_K562_Hela2.39869224
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.32298932
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.29841083
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.21364561
10EZH2_27294783_Chip-Seq_ESCs_Mouse2.14497531
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13392355
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12518096
13VDR_22108803_ChIP-Seq_LS180_Human2.08749455
14SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98969117
15REST_21632747_ChIP-Seq_MESCs_Mouse1.89874094
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88998696
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86810204
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.86183062
19IGF1R_20145208_ChIP-Seq_DFB_Human1.82623871
20RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.80456421
21IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77902771
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75352268
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62763357
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.62136068
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61281647
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61281647
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58597441
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57570136
29RNF2_27304074_Chip-Seq_NSC_Mouse1.55168515
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.54752188
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.54569566
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.53374989
33CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50940177
34GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.48883296
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46094816
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.45857266
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44859900
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.35310092
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35016490
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.34998344
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34227927
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30477166
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29937817
44KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29042515
45ERA_21632823_ChIP-Seq_H3396_Human1.27158089
46SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26362186
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.24537139
48MYC_18940864_ChIP-ChIP_HL60_Human1.23147480
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.22858424
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22785354
51TP53_20018659_ChIP-ChIP_R1E_Mouse1.21523932
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21383795
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20439216
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.18780079
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18058504
56TTF2_22483619_ChIP-Seq_HELA_Human1.17824821
57ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16421996
58YY1_22570637_ChIP-Seq_MALME-3M_Human1.15630997
59TP53_22573176_ChIP-Seq_HFKS_Human1.15293388
60FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14986290
61CTCF_27219007_Chip-Seq_Bcells_Human1.14685160
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13343900
63SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13060448
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11460188
65EWS_26573619_Chip-Seq_HEK293_Human1.09955927
66CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08478897
67NANOG_20526341_ChIP-Seq_ESCs_Human1.08262169
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.07526640
69EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06691325
70AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06594563
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06273528
72TAF2_19829295_ChIP-Seq_ESCs_Human1.05365594
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05173229
74MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05111030
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04453954
76GBX2_23144817_ChIP-Seq_PC3_Human1.04039653
77IRF1_19129219_ChIP-ChIP_H3396_Human1.02964860
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02921296
79SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.02817305
80NCOR_22424771_ChIP-Seq_293T_Human1.02542362
81OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02201216
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02136791
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01449938
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01438072
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00375988
86FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99981731
87FOXA1_25329375_ChIP-Seq_VCAP_Human0.99981731
88FUS_26573619_Chip-Seq_HEK293_Human0.99038099
89BCAT_22108803_ChIP-Seq_LS180_Human0.98964641
90SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97451153
91GATA1_26923725_Chip-Seq_HPCs_Mouse0.96721730
92THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96135320
93RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95962868
94EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93160546
95SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90012757
96P53_21459846_ChIP-Seq_SAOS-2_Human0.87871594
97AR_20517297_ChIP-Seq_VCAP_Human0.87252899
98FOXP3_21729870_ChIP-Seq_TREG_Human0.84344178
99GABP_19822575_ChIP-Seq_HepG2_Human0.83122894
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82930276

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.21227117
2MP0003787_abnormal_imprinting3.87272543
3MP0006292_abnormal_olfactory_placode3.74121917
4MP0003123_paternal_imprinting3.14407994
5MP0002653_abnormal_ependyma_morphology3.13141505
6MP0003122_maternal_imprinting3.05369479
7MP0003121_genomic_imprinting2.64761070
8MP0008877_abnormal_DNA_methylation2.62616362
9MP0004142_abnormal_muscle_tone2.59129952
10MP0005423_abnormal_somatic_nervous2.34701674
11MP0002163_abnormal_gland_morphology2.32341939
12MP0003646_muscle_fatigue2.30807752
13MP0002638_abnormal_pupillary_reflex2.07320206
14MP0006276_abnormal_autonomic_nervous2.03645252
15MP0005083_abnormal_biliary_tract2.02340487
16MP0003136_yellow_coat_color1.99715625
17MP0000778_abnormal_nervous_system1.99005194
18MP0005084_abnormal_gallbladder_morpholo1.92305465
19MP0001293_anophthalmia1.90969130
20MP0008789_abnormal_olfactory_epithelium1.87605672
21MP0001529_abnormal_vocalization1.67241574
22MP0005394_taste/olfaction_phenotype1.61321315
23MP0005499_abnormal_olfactory_system1.61321315
24MP0002272_abnormal_nervous_system1.54541152
25MP0002837_dystrophic_cardiac_calcinosis1.50845282
26MP0005379_endocrine/exocrine_gland_phen1.48185263
27MP0000049_abnormal_middle_ear1.46616364
28MP0005551_abnormal_eye_electrophysiolog1.45640113
29MP0004885_abnormal_endolymph1.44362126
30MP0001485_abnormal_pinna_reflex1.43963634
31MP0004145_abnormal_muscle_electrophysio1.39996630
32MP0001970_abnormal_pain_threshold1.37949930
33MP0002234_abnormal_pharynx_morphology1.37168471
34MP0001968_abnormal_touch/_nociception1.37046080
35MP0003879_abnormal_hair_cell1.35864429
36MP0006072_abnormal_retinal_apoptosis1.32978139
37MP0005646_abnormal_pituitary_gland1.32769835
38MP0002733_abnormal_thermal_nociception1.31156246
39MP0000955_abnormal_spinal_cord1.28232063
40MP0008872_abnormal_physiological_respon1.25527515
41MP0009745_abnormal_behavioral_response1.25243759
42MP0002557_abnormal_social/conspecific_i1.25045170
43MP0001440_abnormal_grooming_behavior1.24117042
44MP0003880_abnormal_central_pattern1.22702993
45MP0004859_abnormal_synaptic_plasticity1.22581730
46MP0003635_abnormal_synaptic_transmissio1.22312650
47MP0004133_heterotaxia1.22119251
48MP0008995_early_reproductive_senescence1.21949410
49MP0009046_muscle_twitch1.21583079
50MP0005195_abnormal_posterior_eye1.20607762
51MP0002063_abnormal_learning/memory/cond1.20241223
52MP0005377_hearing/vestibular/ear_phenot1.20236071
53MP0003878_abnormal_ear_physiology1.20236071
54MP0002184_abnormal_innervation1.16865548
55MP0002572_abnormal_emotion/affect_behav1.15569380
56MP0000631_abnormal_neuroendocrine_gland1.12513790
57MP0002752_abnormal_somatic_nervous1.12205211
58MP0003786_premature_aging1.11666782
59MP0001905_abnormal_dopamine_level1.09929297
60MP0003011_delayed_dark_adaptation1.09823850
61MP0004742_abnormal_vestibular_system1.09225009
62MP0003567_abnormal_fetal_cardiomyocyte1.08631720
63MP0002736_abnormal_nociception_after1.06269146
64MP0003942_abnormal_urinary_system1.02785406
65MP0000026_abnormal_inner_ear1.02119857
66MP0002735_abnormal_chemical_nociception0.98013595
67MP0005389_reproductive_system_phenotype0.97979397
68MP0002734_abnormal_mechanical_nocicepti0.96873186
69MP0001986_abnormal_taste_sensitivity0.95380847
70MP0002138_abnormal_hepatobiliary_system0.95014203
71MP0009764_decreased_sensitivity_to0.94064191
72MP0001963_abnormal_hearing_physiology0.91510599
73MP0002064_seizures0.91389553
74MP0001919_abnormal_reproductive_system0.90323734
75MP0001984_abnormal_olfaction0.87951693
76MP0004043_abnormal_pH_regulation0.87894952
77MP0002102_abnormal_ear_morphology0.87829653
78MP0002882_abnormal_neuron_morphology0.87438528
79MP0002277_abnormal_respiratory_mucosa0.85227714
80MP0000566_synostosis0.83041199
81MP0002160_abnormal_reproductive_system0.82511654
82MP0003315_abnormal_perineum_morphology0.81770082
83MP0005386_behavior/neurological_phenoty0.80817349
84MP0004924_abnormal_behavior0.80817349
85MP0004147_increased_porphyrin_level0.79817605
86MP0002938_white_spotting0.79742046
87MP0003195_calcinosis0.79287492
88MP0002067_abnormal_sensory_capabilities0.78086467
89MP0002233_abnormal_nose_morphology0.77957878
90MP0002229_neurodegeneration0.77264656
91MP0002152_abnormal_brain_morphology0.76788747
92MP0006035_abnormal_mitochondrial_morpho0.74277876
93MP0001663_abnormal_digestive_system0.73786551
94MP0001502_abnormal_circadian_rhythm0.73232458
95MP0001486_abnormal_startle_reflex0.70386019
96MP0002095_abnormal_skin_pigmentation0.68737637
97MP0005253_abnormal_eye_physiology0.65856236
98MP0003861_abnormal_nervous_system0.65728469
99MP0005391_vision/eye_phenotype0.64407680
100MP0004811_abnormal_neuron_physiology0.64367590

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.72194016
2Acute necrotizing encephalopathy (HP:0006965)3.95276375
3Pancreatic fibrosis (HP:0100732)3.91015955
4Abnormality of midbrain morphology (HP:0002418)3.83840220
5Molar tooth sign on MRI (HP:0002419)3.83840220
6Abnormality of cells of the erythroid lineage (HP:0012130)3.57701910
7Abnormal mitochondria in muscle tissue (HP:0008316)3.53502985
8Stenosis of the external auditory canal (HP:0000402)3.40892273
9Acute encephalopathy (HP:0006846)3.39455810
10Macrocytic anemia (HP:0001972)3.36371405
11Medial flaring of the eyebrow (HP:0010747)3.35836949
12Myokymia (HP:0002411)3.31930358
13True hermaphroditism (HP:0010459)3.31010412
14Agitation (HP:0000713)3.29814094
15Septo-optic dysplasia (HP:0100842)3.06892049
16Pancreatic cysts (HP:0001737)3.04412230
17Progressive macrocephaly (HP:0004481)3.01453503
18Mitochondrial inheritance (HP:0001427)2.94665451
19Abnormality of DNA repair (HP:0003254)2.93903650
20Gait imbalance (HP:0002141)2.93182395
21Absent rod-and cone-mediated responses on ERG (HP:0007688)2.84827327
22Nephronophthisis (HP:0000090)2.79573096
23Absent/shortened dynein arms (HP:0200106)2.74522803
24Dynein arm defect of respiratory motile cilia (HP:0012255)2.74522803
25Pallor (HP:0000980)2.65133362
26Abnormal hemoglobin (HP:0011902)2.63756274
27Congenital primary aphakia (HP:0007707)2.63360703
28Abnormal rod and cone electroretinograms (HP:0008323)2.63244785
29Confusion (HP:0001289)2.62150730
30Congenital stationary night blindness (HP:0007642)2.60361767
31Increased CSF lactate (HP:0002490)2.51336813
32Type II lissencephaly (HP:0007260)2.50597147
33Abnormal respiratory motile cilium morphology (HP:0005938)2.49472195
34Abnormal respiratory epithelium morphology (HP:0012253)2.49472195
35Absent thumb (HP:0009777)2.48744590
36Nephrogenic diabetes insipidus (HP:0009806)2.48146138
37Cystic liver disease (HP:0006706)2.46760809
38Adrenal hypoplasia (HP:0000835)2.46587970
39Abnormality of the labia minora (HP:0012880)2.43686893
40Cerebellar dysplasia (HP:0007033)2.39621177
41Anencephaly (HP:0002323)2.36512574
42Sclerocornea (HP:0000647)2.34332136
43Cerebral edema (HP:0002181)2.34164909
44Abnormality of the corticospinal tract (HP:0002492)2.29391798
45Abnormal ciliary motility (HP:0012262)2.26387293
46Hepatocellular necrosis (HP:0001404)2.26279756
47Optic disc pallor (HP:0000543)2.23684131
48Colon cancer (HP:0003003)2.21332007
49Lipid accumulation in hepatocytes (HP:0006561)2.20900533
50Poor coordination (HP:0002370)2.19722804
51Supernumerary spleens (HP:0009799)2.19564460
52Abnormality of the renal medulla (HP:0100957)2.19458981
53Oligodactyly (hands) (HP:0001180)2.19123411
54Depressed nasal ridge (HP:0000457)2.18762282
55Rib fusion (HP:0000902)2.18682851
56Degeneration of the lateral corticospinal tracts (HP:0002314)2.17555905
57Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.17555905
58Optic nerve hypoplasia (HP:0000609)2.16901514
59Focal motor seizures (HP:0011153)2.12887577
60Pachygyria (HP:0001302)2.10397466
61Lissencephaly (HP:0001339)2.08326708
62Occipital encephalocele (HP:0002085)2.07281395
63Failure to thrive in infancy (HP:0001531)2.06984769
64Diastasis recti (HP:0001540)2.06358507
65Anomalous pulmonary venous return (HP:0010772)2.05845055
66Pendular nystagmus (HP:0012043)2.05511976
67Male pseudohermaphroditism (HP:0000037)2.05473114
68Impulsivity (HP:0100710)2.04037632
69Aplasia/Hypoplasia of the spleen (HP:0010451)2.02980317
70Postaxial foot polydactyly (HP:0001830)2.00764533
71Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.98164854
72Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97083027
73Vaginal atresia (HP:0000148)1.96869657
74Abnormal respiratory motile cilium physiology (HP:0012261)1.95142661
75Maternal diabetes (HP:0009800)1.94602768
76Ectopic kidney (HP:0000086)1.94395044
77Hyperglycinemia (HP:0002154)1.92240801
78Genital tract atresia (HP:0001827)1.91999467
79Hepatic necrosis (HP:0002605)1.91108772
80Oligodactyly (HP:0012165)1.91080700
81Abnormal number of erythroid precursors (HP:0012131)1.90337771
82Postaxial hand polydactyly (HP:0001162)1.89641650
83Chronic hepatic failure (HP:0100626)1.89575962
84Polyphagia (HP:0002591)1.88714022
85Polydipsia (HP:0001959)1.87709167
86Abnormal drinking behavior (HP:0030082)1.87709167
87Increased hepatocellular lipid droplets (HP:0006565)1.87230367
88Abnormality of alanine metabolism (HP:0010916)1.86790227
89Hyperalaninemia (HP:0003348)1.86790227
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86790227
91Asplenia (HP:0001746)1.86511097
92Holoprosencephaly (HP:0001360)1.86129319
93Partial duplication of thumb phalanx (HP:0009944)1.85003156
94Tubular atrophy (HP:0000092)1.84743762
95Anophthalmia (HP:0000528)1.83529507
96Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82733193
97Narrow forehead (HP:0000341)1.82303047
98Hypoplasia of the ulna (HP:0003022)1.81099189
99Abnormality of reticulocytes (HP:0004312)1.80994047
100Congenital hepatic fibrosis (HP:0002612)1.80742526

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK165.25312384
2WNK43.29746951
3DYRK22.84403205
4TIE12.67003821
5GRK12.33352704
6EPHB22.31672057
7PIK3CA2.30157309
8TYRO32.13794488
9MAP3K112.13785365
10ADRBK22.09119027
11TAOK32.07903251
12TXK1.81031085
13MINK11.75396697
14MAPK131.69299884
15MARK11.67383052
16BCR1.65862515
17CDK191.64295902
18PINK11.57185716
19CASK1.54992905
20PLK21.54709639
21BCKDK1.51328597
22PRKCQ1.49696461
23CAMKK21.39310411
24PLK41.38745533
25MAP4K21.36242887
26LIMK11.35304537
27LRRK21.28982786
28CSNK1G21.27608262
29NUAK11.27254467
30PAK31.12260996
31CAMK11.11538573
32NTRK21.10299847
33NEK11.08037265
34PRKCG1.06709628
35CSNK1G31.06661359
36CDC71.03264759
37WNK11.01695462
38OXSR10.97785607
39STK110.95271259
40WNK30.93397608
41CAMK1D0.89683172
42DAPK30.89546623
43ADRBK10.88908401
44PNCK0.88559610
45STK390.88259150
46MAP3K120.85873025
47VRK20.85536500
48MAP2K40.82277424
49CAMK40.81645433
50INSRR0.80103667
51CSNK1A1L0.79027271
52CSNK1G10.75971906
53PRKACA0.73318792
54PRKCI0.72481752
55ABL20.72191312
56PHKG10.70998604
57PHKG20.70998604
58MAP2K60.70506138
59KDR0.69332125
60TRIM280.68268758
61ZAK0.67167715
62SGK10.66489443
63PRKCH0.65894022
64SGK2230.65454816
65SGK4940.65454816
66PRKCZ0.62435201
67STK30.62249346
68CSNK1A10.60545853
69TEC0.59688185
70PDK20.59500238
71CAMK1G0.59005131
72AURKA0.58605949
73DAPK20.57218203
74MAP3K40.56101608
75CSNK2A20.55437190
76TNK20.54741371
77MAP2K70.53800281
78KSR10.53730115
79CDK140.53125287
80EPHA40.52227066
81TAF10.52221091
82CSNK1E0.51830402
83NEK20.50957162
84CAMK2A0.49792069
85TGFBR10.48694912
86PRKCD0.47838110
87PRKCA0.46890445
88MAPK120.46247869
89TAOK20.45945357
90BMPR1B0.44041638
91ERBB20.42579192
92RPS6KA30.40974786
93MAPK150.40463609
94PRKACG0.39972243
95PLK10.39690157
96CAMKK10.39224240
97FRK0.37213557
98PKN10.36710934
99FES0.36463998
100AKT10.36393217

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.13915984
2Oxidative phosphorylation_Homo sapiens_hsa001903.96572940
3Parkinsons disease_Homo sapiens_hsa050123.47296861
4Cardiac muscle contraction_Homo sapiens_hsa042602.85484578
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.53918907
6Alzheimers disease_Homo sapiens_hsa050102.45819628
7Huntingtons disease_Homo sapiens_hsa050162.41984727
8Protein export_Homo sapiens_hsa030602.40779145
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.31093369
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.24471658
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.07723102
12Peroxisome_Homo sapiens_hsa041461.90633434
13Linoleic acid metabolism_Homo sapiens_hsa005911.82158948
14RNA degradation_Homo sapiens_hsa030181.71201931
15Phototransduction_Homo sapiens_hsa047441.62292730
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.60008670
17Steroid biosynthesis_Homo sapiens_hsa001001.56794658
18Butanoate metabolism_Homo sapiens_hsa006501.44088602
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44075710
20RNA polymerase_Homo sapiens_hsa030201.42013795
21Propanoate metabolism_Homo sapiens_hsa006401.41466729
22Sulfur relay system_Homo sapiens_hsa041221.40667023
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39109247
24Nicotine addiction_Homo sapiens_hsa050331.34926159
25Fanconi anemia pathway_Homo sapiens_hsa034601.33047170
26Retinol metabolism_Homo sapiens_hsa008301.26929735
27Tryptophan metabolism_Homo sapiens_hsa003801.24393049
28Basal cell carcinoma_Homo sapiens_hsa052171.18189954
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17408515
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17323117
31Proteasome_Homo sapiens_hsa030501.16240330
32Caffeine metabolism_Homo sapiens_hsa002321.14377531
33Basal transcription factors_Homo sapiens_hsa030221.11410228
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11256196
35Nitrogen metabolism_Homo sapiens_hsa009101.07657824
36beta-Alanine metabolism_Homo sapiens_hsa004101.03503915
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02407187
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01368231
39Collecting duct acid secretion_Homo sapiens_hsa049661.01183513
40Fat digestion and absorption_Homo sapiens_hsa049751.00212164
41Chemical carcinogenesis_Homo sapiens_hsa052040.99947968
42Fatty acid degradation_Homo sapiens_hsa000710.97469516
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.94149312
44Insulin secretion_Homo sapiens_hsa049110.88613368
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87300685
46Arachidonic acid metabolism_Homo sapiens_hsa005900.85968221
47Arginine and proline metabolism_Homo sapiens_hsa003300.85318259
48Primary immunodeficiency_Homo sapiens_hsa053400.84732302
49Notch signaling pathway_Homo sapiens_hsa043300.83602333
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77898666
51Pyrimidine metabolism_Homo sapiens_hsa002400.77817932
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76476602
53Homologous recombination_Homo sapiens_hsa034400.75451098
54Hedgehog signaling pathway_Homo sapiens_hsa043400.74433404
55Ovarian steroidogenesis_Homo sapiens_hsa049130.73604147
56Nucleotide excision repair_Homo sapiens_hsa034200.73601492
57Ether lipid metabolism_Homo sapiens_hsa005650.73382459
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70427531
59Olfactory transduction_Homo sapiens_hsa047400.69961073
60Metabolic pathways_Homo sapiens_hsa011000.67942280
61Axon guidance_Homo sapiens_hsa043600.67520177
62Glutamatergic synapse_Homo sapiens_hsa047240.65811883
63Hippo signaling pathway_Homo sapiens_hsa043900.64645598
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62586948
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62029437
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59731790
67Purine metabolism_Homo sapiens_hsa002300.58880895
68Synaptic vesicle cycle_Homo sapiens_hsa047210.58574554
69Dorso-ventral axis formation_Homo sapiens_hsa043200.56186412
70Morphine addiction_Homo sapiens_hsa050320.54261521
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46666037
72GABAergic synapse_Homo sapiens_hsa047270.45958727
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44807379
74Pyruvate metabolism_Homo sapiens_hsa006200.44057247
75Fatty acid elongation_Homo sapiens_hsa000620.42965623
76Pancreatic secretion_Homo sapiens_hsa049720.42307500
77Oxytocin signaling pathway_Homo sapiens_hsa049210.40975801
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.40878218
79Salivary secretion_Homo sapiens_hsa049700.40501510
80Glycerolipid metabolism_Homo sapiens_hsa005610.38498268
81Asthma_Homo sapiens_hsa053100.37412411
82Bile secretion_Homo sapiens_hsa049760.37232591
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34089769
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.33831256
85Fatty acid metabolism_Homo sapiens_hsa012120.33495409
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.32445057
87Folate biosynthesis_Homo sapiens_hsa007900.31905497
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29114446
89Circadian entrainment_Homo sapiens_hsa047130.28243913
90Cholinergic synapse_Homo sapiens_hsa047250.28118367
91Starch and sucrose metabolism_Homo sapiens_hsa005000.28064656
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25734705
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23931885
94Gastric acid secretion_Homo sapiens_hsa049710.23722680
95Vitamin B6 metabolism_Homo sapiens_hsa007500.22405206
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22023165
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19509513
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.19271816
99Taste transduction_Homo sapiens_hsa047420.19192548
100Melanogenesis_Homo sapiens_hsa049160.18596196

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