ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.27559496
2	maturation of SSU-rRNA (GO:0030490)	4.75991365
3	cellular response to interferon-beta (GO:0035458)	4.60923201
4	viral transcription (GO:0019083)	4.53145454
5	negative regulation of oligodendrocyte differentiation (GO:0048715)	4.45534049
6	translational termination (GO:0006415)	4.27746097
7	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.22468175
8	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.22468175
9	ribosomal small subunit biogenesis (GO:0042274)	4.16014810
10	positive regulation of astrocyte differentiation (GO:0048711)	4.13939730
11	peptidyl-histidine modification (GO:0018202)	4.01835371
12	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	4.00556449
13	ribosomal small subunit assembly (GO:0000028)	3.80853135
14	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.74883921
15	ribosomal large subunit biogenesis (GO:0042273)	3.74195788
16	chaperone-mediated protein transport (GO:0072321)	3.71672383
17	rRNA catabolic process (GO:0016075)	3.68113477
18	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.66970571
19	protein targeting to ER (GO:0045047)	3.64278520
20	regulation of chronic inflammatory response (GO:0002676)	3.63289228
21	cotranslational protein targeting to membrane (GO:0006613)	3.61797667
22	nonmotile primary cilium assembly (GO:0035058)	3.60796099
23	translational elongation (GO:0006414)	3.59301719
24	ribonucleoprotein complex biogenesis (GO:0022613)	3.58411345
25	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.56946021
26	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.52444356
27	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.52047869
28	protein localization to endoplasmic reticulum (GO:0070972)	3.49172907
29	viral life cycle (GO:0019058)	3.46581239
30	rRNA modification (GO:0000154)	3.43162266
31	ribosome biogenesis (GO:0042254)	3.39517912
32	regulation of cilium movement (GO:0003352)	3.35141546
33	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	3.34091643
34	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.33480116
35	substrate-independent telencephalic tangential migration (GO:0021826)	3.33480116
36	resolution of meiotic recombination intermediates (GO:0000712)	3.32661992
37	maturation of 5.8S rRNA (GO:0000460)	3.28717447
38	cellular protein complex disassembly (GO:0043624)	3.25761333
39	cellular component biogenesis (GO:0044085)	3.25481484
40	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	3.24716217
41	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.19129545
42	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.19129545
43	NADH dehydrogenase complex assembly (GO:0010257)	3.19129545
44	aldehyde catabolic process (GO:0046185)	3.18111792
45	axon ensheathment in central nervous system (GO:0032291)	3.15210389
46	central nervous system myelination (GO:0022010)	3.15210389
47	translational initiation (GO:0006413)	3.15145919
48	olfactory bulb development (GO:0021772)	3.14101238
49	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.09129561
50	rRNA methylation (GO:0031167)	3.07015542
51	protein neddylation (GO:0045116)	3.03518696
52	behavioral response to ethanol (GO:0048149)	3.01758652
53	cell proliferation in forebrain (GO:0021846)	3.01389170
54	positive regulation of defense response to virus by host (GO:0002230)	3.00288562
55	preassembly of GPI anchor in ER membrane (GO:0016254)	2.98978644
56	base-excision repair, AP site formation (GO:0006285)	2.98770294
57	ATP synthesis coupled proton transport (GO:0015986)	2.97381036
58	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.97381036
59	segment specification (GO:0007379)	2.97232936
60	rRNA metabolic process (GO:0016072)	2.94974492
61	synaptic transmission, cholinergic (GO:0007271)	2.93184374
62	protein polyglutamylation (GO:0018095)	2.93174674
63	rRNA processing (GO:0006364)	2.92844483
64	Peyers patch development (GO:0048541)	2.91799206
65	mucosal-associated lymphoid tissue development (GO:0048537)	2.91799206
66	piRNA metabolic process (GO:0034587)	2.89668534
67	replication fork processing (GO:0031297)	2.88826022
68	cell wall macromolecule catabolic process (GO:0016998)	2.85835369
69	natural killer cell differentiation (GO:0001779)	2.85600590
70	mannosylation (GO:0097502)	2.85014866
71	pyrimidine nucleotide catabolic process (GO:0006244)	2.84968491
72	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.83360047
73	regulation of immunoglobulin secretion (GO:0051023)	2.82707299
74	positive regulation of glial cell differentiation (GO:0045687)	2.82458463
75	spindle assembly involved in mitosis (GO:0090307)	2.82257374
76	replicative senescence (GO:0090399)	2.80960993
77	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	2.76543326
78	negative regulation of glial cell differentiation (GO:0045686)	2.76130676
79	protein complex disassembly (GO:0043241)	2.74996779
80	spinal cord association neuron differentiation (GO:0021527)	2.74382680
81	response to pheromone (GO:0019236)	2.74245169
82	protein import into peroxisome matrix (GO:0016558)	2.71317849
83	regulation of microtubule-based movement (GO:0060632)	2.70139854
84	regulation of astrocyte differentiation (GO:0048710)	2.69650773
85	parturition (GO:0007567)	2.68903472
86	protein deneddylation (GO:0000338)	2.68666283
87	intracellular protein transmembrane import (GO:0044743)	2.68191473
88	negative regulation of telomere maintenance (GO:0032205)	2.67807702
89	macromolecular complex disassembly (GO:0032984)	2.66677306
90	regulation of oligodendrocyte differentiation (GO:0048713)	2.65981629
91	DNA damage response, detection of DNA damage (GO:0042769)	2.65484246
92	leukocyte aggregation (GO:0070486)	2.65473318
93	translation (GO:0006412)	2.65310268
94	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.64087075
95	somite development (GO:0061053)	2.62232642
96	negative regulation of T cell differentiation in thymus (GO:0033085)	2.61850752
97	nucleotide transmembrane transport (GO:1901679)	2.60378713
98	protein localization to cilium (GO:0061512)	2.60076816
99	inner mitochondrial membrane organization (GO:0007007)	2.59209998
100	positive regulation of humoral immune response (GO:0002922)	2.57593729

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.87764163
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.38542911
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.37893659
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.91018431
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.91013135
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.82760819
7	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.68378305
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.52951567
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.40278033
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.30120576
11	VDR_22108803_ChIP-Seq_LS180_Human	2.28044786
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.14244315
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.08483132
14	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.04937478
15	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.00162092
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.99779913
17	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.84195208
18	VDR_23849224_ChIP-Seq_CD4+_Human	1.81160680
19	TTF2_22483619_ChIP-Seq_HELA_Human	1.77966445
20	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.73929492
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.72297510
22	FUS_26573619_Chip-Seq_HEK293_Human	1.70664733
23	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.66605430
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.66550131
25	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.66023705
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.64749419
27	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.62734099
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61794092
29	GABP_19822575_ChIP-Seq_HepG2_Human	1.61735122
30	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.60719894
31	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.60088349
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.58191862
33	REST_21632747_ChIP-Seq_MESCs_Mouse	1.53427467
34	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.52816508
35	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.52746824
36	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.52637541
37	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.50759484
38	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.50443705
39	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.44856767
40	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.43983666
41	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.42145610
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.42058670
43	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.41886462
44	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.40764262
45	FOXP3_21729870_ChIP-Seq_TREG_Human	1.39457978
46	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.38496688
47	XRN2_22483619_ChIP-Seq_HELA_Human	1.38295007
48	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.34925539
49	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24871406
50	RNF2_27304074_Chip-Seq_NSC_Mouse	1.23186845
51	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.20933528
52	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19670098
53	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.17256551
54	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.17253565
55	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.17108780
56	ER_23166858_ChIP-Seq_MCF-7_Human	1.16014549
57	NCOR_22424771_ChIP-Seq_293T_Human	1.15832939
58	GATA1_22025678_ChIP-Seq_K562_Human	1.15505219
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.15124326
60	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.15108596
61	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.15096850
62	GBX2_23144817_ChIP-Seq_PC3_Human	1.14784425
63	NANOG_20526341_ChIP-Seq_ESCs_Human	1.14369395
64	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.13813464
65	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13813464
66	ELK1_19687146_ChIP-ChIP_HELA_Human	1.12926341
67	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.12446883
68	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.11749983
69	P53_21459846_ChIP-Seq_SAOS-2_Human	1.11288823
70	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.11076019
71	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.09743141
72	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.09726949
73	IRF1_19129219_ChIP-ChIP_H3396_Human	1.08925260
74	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06283904
75	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.06199941
76	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.05957737
77	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.05491021
78	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04867424
79	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04867424
80	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.03502030
81	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.03257636
82	ERA_21632823_ChIP-Seq_H3396_Human	1.03008537
83	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.02935974
84	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.02745290
85	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.02252971
86	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.01751156
87	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.01751156
88	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.00949560
89	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.00400424
90	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99899142
91	E2F1_20622854_ChIP-Seq_HELA_Human	0.98600780
92	TCF4_22108803_ChIP-Seq_LS180_Human	0.98520936
93	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97102132
94	EWS_26573619_Chip-Seq_HEK293_Human	0.96906764
95	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.95324603
96	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.95114140
97	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.93983764
98	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.93497301
99	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.93241807
100	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.91890344

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	3.63203143
2	MP0006292_abnormal_olfactory_placode	3.59627448
3	MP0002653_abnormal_ependyma_morphology	3.54830070
4	MP0009379_abnormal_foot_pigmentation	3.45258379
5	MP0001984_abnormal_olfaction	3.28110819
6	MP0002163_abnormal_gland_morphology	2.87567369
7	MP0003787_abnormal_imprinting	2.76247659
8	MP0006276_abnormal_autonomic_nervous	2.43856901
9	MP0003122_maternal_imprinting	2.27996346
10	MP0005646_abnormal_pituitary_gland	2.25878909
11	MP0004142_abnormal_muscle_tone	2.11889390
12	MP0001502_abnormal_circadian_rhythm	1.94322192
13	MP0000372_irregular_coat_pigmentation	1.93435750
14	MP0003880_abnormal_central_pattern	1.90220648
15	MP0003646_muscle_fatigue	1.87997825
16	MP0001529_abnormal_vocalization	1.86269423
17	MP0001968_abnormal_touch/_nociception	1.83685806
18	MP0005379_endocrine/exocrine_gland_phen	1.80868327
19	MP0001501_abnormal_sleep_pattern	1.75878228
20	MP0008789_abnormal_olfactory_epithelium	1.74042943
21	MP0003878_abnormal_ear_physiology	1.66067952
22	MP0005377_hearing/vestibular/ear_phenot	1.66067952
23	MP0008877_abnormal_DNA_methylation	1.64749627
24	MP0000778_abnormal_nervous_system	1.63097548
25	MP0002102_abnormal_ear_morphology	1.56170389
26	MP0002736_abnormal_nociception_after	1.55238474
27	MP0002272_abnormal_nervous_system	1.54073231
28	MP0001293_anophthalmia	1.52724596
29	MP0001986_abnormal_taste_sensitivity	1.52523412
30	MP0003121_genomic_imprinting	1.52306909
31	MP0003195_calcinosis	1.48970785
32	MP0008872_abnormal_physiological_respon	1.48961858
33	MP0004742_abnormal_vestibular_system	1.48040838
34	MP0005499_abnormal_olfactory_system	1.47894662
35	MP0005394_taste/olfaction_phenotype	1.47894662
36	MP0005551_abnormal_eye_electrophysiolog	1.47508775
37	MP0003879_abnormal_hair_cell	1.47355453
38	MP0009046_muscle_twitch	1.47298550
39	MP0002876_abnormal_thyroid_physiology	1.45226715
40	MP0003123_paternal_imprinting	1.43352720
41	MP0002837_dystrophic_cardiac_calcinosis	1.41114816
42	MP0009745_abnormal_behavioral_response	1.38902483
43	MP0005423_abnormal_somatic_nervous	1.38673386
44	MP0002006_tumorigenesis	1.38173026
45	MP0001188_hyperpigmentation	1.35056355
46	MP0000049_abnormal_middle_ear	1.34577201
47	MP0009764_decreased_sensitivity_to	1.30986787
48	MP0006072_abnormal_retinal_apoptosis	1.28215070
49	MP0005645_abnormal_hypothalamus_physiol	1.23025600
50	MP0005171_absent_coat_pigmentation	1.22779238
51	MP0001348_abnormal_lacrimal_gland	1.21882711
52	MP0003959_abnormal_lean_body	1.20855590
53	MP0000631_abnormal_neuroendocrine_gland	1.20737713
54	MP0000955_abnormal_spinal_cord	1.18875633
55	MP0002234_abnormal_pharynx_morphology	1.17956273
56	MP0003693_abnormal_embryo_hatching	1.17837814
57	MP0004885_abnormal_endolymph	1.16695497
58	MP0005195_abnormal_posterior_eye	1.13238225
59	MP0002733_abnormal_thermal_nociception	1.12281555
60	MP0001970_abnormal_pain_threshold	1.10988874
61	MP0008875_abnormal_xenobiotic_pharmacok	1.10911800
62	MP0001485_abnormal_pinna_reflex	1.10458458
63	MP0002557_abnormal_social/conspecific_i	1.10418384
64	MP0005387_immune_system_phenotype	1.08968663
65	MP0001790_abnormal_immune_system	1.08968663
66	MP0010030_abnormal_orbit_morphology	1.06819202
67	MP0001905_abnormal_dopamine_level	1.05542820
68	MP0001440_abnormal_grooming_behavior	1.05250845
69	MP0000026_abnormal_inner_ear	1.03416046
70	MP0000685_abnormal_immune_system	1.02934116
71	MP0002572_abnormal_emotion/affect_behav	1.01406037
72	MP0002752_abnormal_somatic_nervous	1.00287597
73	MP0002735_abnormal_chemical_nociception	1.00122668
74	MP0000465_gastrointestinal_hemorrhage	1.00073837
75	MP0004133_heterotaxia	0.99440511
76	MP0003283_abnormal_digestive_organ	0.98435072
77	MP0003436_decreased_susceptibility_to	0.98029193
78	MP0002063_abnormal_learning/memory/cond	0.97689371
79	MP0002138_abnormal_hepatobiliary_system	0.93798875
80	MP0002160_abnormal_reproductive_system	0.90246086
81	MP0002148_abnormal_hypersensitivity_rea	0.89398131
82	MP0002184_abnormal_innervation	0.88796517
83	MP0003635_abnormal_synaptic_transmissio	0.88043852
84	MP0003186_abnormal_redox_activity	0.86309476
85	MP0001663_abnormal_digestive_system	0.84475985
86	MP0001286_abnormal_eye_development	0.84192725
87	MP0003718_maternal_effect	0.83001115
88	MP0002067_abnormal_sensory_capabilities	0.82812626
89	MP0005389_reproductive_system_phenotype	0.81208656
90	MP0002064_seizures	0.81169144
91	MP0001346_abnormal_lacrimal_gland	0.80607905
92	MP0002882_abnormal_neuron_morphology	0.78469412
93	MP0010386_abnormal_urinary_bladder	0.77547868
94	MP0002734_abnormal_mechanical_nocicepti	0.75798541
95	MP0000613_abnormal_salivary_gland	0.75089559
96	MP0001835_abnormal_antigen_presentation	0.73946659
97	MP0004145_abnormal_muscle_electrophysio	0.70273729
98	MP0002229_neurodegeneration	0.69783138
99	MP0002938_white_spotting	0.68213205
100	MP0001881_abnormal_mammary_gland	0.66944474

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.33615013
2	3-Methylglutaconic aciduria (HP:0003535)	4.72046195
3	Type II lissencephaly (HP:0007260)	4.54249074
4	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.39637164
5	Abnormality of midbrain morphology (HP:0002418)	4.14580752
6	Molar tooth sign on MRI (HP:0002419)	4.14580752
7	Elevated erythrocyte sedimentation rate (HP:0003565)	3.69879105
8	Abnormality of the labia minora (HP:0012880)	3.67469964
9	Abnormality of alanine metabolism (HP:0010916)	3.58884615
10	Hyperalaninemia (HP:0003348)	3.58884615
11	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.58884615
12	Abnormal rod and cone electroretinograms (HP:0008323)	3.57234904
13	Medial flaring of the eyebrow (HP:0010747)	3.41204863
14	Pancreatic cysts (HP:0001737)	3.39420962
15	Pendular nystagmus (HP:0012043)	3.34720695
16	Thoracolumbar scoliosis (HP:0002944)	3.25131365
17	Abnormality of cells of the erythroid lineage (HP:0012130)	3.19544011
18	Decreased central vision (HP:0007663)	3.19167153
19	Microretrognathia (HP:0000308)	3.18397357
20	Pancreatic fibrosis (HP:0100732)	3.14663521
21	Congenital stationary night blindness (HP:0007642)	3.14512906
22	Stenosis of the external auditory canal (HP:0000402)	3.10221202
23	Cerebellar dysplasia (HP:0007033)	3.09387942
24	Stomatitis (HP:0010280)	2.84855269
25	Macrocytic anemia (HP:0001972)	2.78577481
26	True hermaphroditism (HP:0010459)	2.78390097
27	Gait imbalance (HP:0002141)	2.78345249
28	Congenital primary aphakia (HP:0007707)	2.76341942
29	Nephronophthisis (HP:0000090)	2.68205609
30	Acute necrotizing encephalopathy (HP:0006965)	2.64894130
31	Agitation (HP:0000713)	2.57115645
32	Abnormality of DNA repair (HP:0003254)	2.56470428
33	Nephrogenic diabetes insipidus (HP:0009806)	2.55347068
34	Retinal dysplasia (HP:0007973)	2.50024403
35	Abnormal hair whorl (HP:0010721)	2.49791432
36	Abnormal number of erythroid precursors (HP:0012131)	2.46710675
37	Cystic liver disease (HP:0006706)	2.44162973
38	Abolished electroretinogram (ERG) (HP:0000550)	2.39955464
39	Rib fusion (HP:0000902)	2.33599418
40	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.29677881
41	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.27593846
42	Absent/shortened dynein arms (HP:0200106)	2.27593846
43	Lissencephaly (HP:0001339)	2.26912724
44	Anencephaly (HP:0002323)	2.26602031
45	Absent thumb (HP:0009777)	2.23856644
46	Abnormal mitochondria in muscle tissue (HP:0008316)	2.20723715
47	Sensorimotor neuropathy (HP:0007141)	2.20340501
48	Reduced antithrombin III activity (HP:0001976)	2.17430291
49	Optic nerve hypoplasia (HP:0000609)	2.12343862
50	IgG deficiency (HP:0004315)	2.11968823
51	Poor coordination (HP:0002370)	2.10628185
52	Optic disc pallor (HP:0000543)	2.09886313
53	Increased intramyocellular lipid droplets (HP:0012240)	2.08531755
54	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.07962019
55	Mitochondrial inheritance (HP:0001427)	2.06987529
56	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.06636861
57	Anterior segment dysgenesis (HP:0007700)	2.05923126
58	Pallor (HP:0000980)	2.03722881
59	Abnormality of the renal medulla (HP:0100957)	2.02893380
60	Growth hormone deficiency (HP:0000824)	2.01897567
61	Progressive macrocephaly (HP:0004481)	2.01770526
62	Acute encephalopathy (HP:0006846)	1.99680848
63	Increased CSF lactate (HP:0002490)	1.99356919
64	Increased serum lactate (HP:0002151)	1.98103749
65	Diastasis recti (HP:0001540)	1.96566090
66	Retinitis pigmentosa (HP:0000510)	1.95585484
67	Vaginal atresia (HP:0000148)	1.92065461
68	Facial hemangioma (HP:0000329)	1.86796073
69	Abnormal biliary tract physiology (HP:0012439)	1.86447223
70	Bile duct proliferation (HP:0001408)	1.86447223
71	Septo-optic dysplasia (HP:0100842)	1.86053485
72	Abnormal respiratory motile cilium morphology (HP:0005938)	1.82483659
73	Abnormal respiratory epithelium morphology (HP:0012253)	1.82483659
74	Abnormal hemoglobin (HP:0011902)	1.82260044
75	Thyroid-stimulating hormone excess (HP:0002925)	1.81594137
76	Poor suck (HP:0002033)	1.81321559
77	Sclerocornea (HP:0000647)	1.80553231
78	Narrow forehead (HP:0000341)	1.79365829
79	Adrenal hypoplasia (HP:0000835)	1.79321607
80	Myokymia (HP:0002411)	1.78812728
81	Asplenia (HP:0001746)	1.78050205
82	Genital tract atresia (HP:0001827)	1.76935128
83	Attenuation of retinal blood vessels (HP:0007843)	1.75627783
84	Increased corneal curvature (HP:0100692)	1.73906794
85	Keratoconus (HP:0000563)	1.73906794
86	Severe muscular hypotonia (HP:0006829)	1.73047124
87	Pachygyria (HP:0001302)	1.73037056
88	Meningocele (HP:0002435)	1.73030952
89	Hypoplasia of the brainstem (HP:0002365)	1.72795358
90	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.72795358
91	Abnormality of macular pigmentation (HP:0008002)	1.71909437
92	Retinal atrophy (HP:0001105)	1.71209454
93	Anophthalmia (HP:0000528)	1.71053772
94	Arthropathy (HP:0003040)	1.69807086
95	Dandy-Walker malformation (HP:0001305)	1.69153445
96	Postaxial foot polydactyly (HP:0001830)	1.68170973
97	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.68076129
98	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.68076129
99	Bony spicule pigmentary retinopathy (HP:0007737)	1.67535693
100	Increased muscle lipid content (HP:0009058)	1.63685228

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TSSK6	5.58069495
2	EIF2AK1	3.80756285
3	MAP4K2	3.02092500
4	AKT3	2.64209964
5	TAOK3	2.48271043
6	STK16	2.45631623
7	ADRBK2	2.33737828
8	CDK19	2.28086512
9	ZAK	1.89010987
10	NUAK1	1.84010095
11	EIF2AK3	1.84008379
12	TXK	1.81333241
13	WNK4	1.75081129
14	PINK1	1.66449083
15	TLK1	1.63781166
16	TIE1	1.56646724
17	MUSK	1.51863545
18	ALK	1.49007116
19	DYRK2	1.48276035
20	EPHB2	1.41646805
21	WNK3	1.40582483
22	BCR	1.32424363
23	BCKDK	1.31836299
24	EPHA4	1.29303196
25	SIK2	1.28780857
26	BMPR1B	1.25482973
27	SRPK1	1.23688264
28	GRK1	1.23620551
29	DYRK3	1.21827546
30	TYRO3	1.13008546
31	DAPK2	1.11909101
32	KIT	1.08442244
33	TYK2	0.99116140
34	PDK2	0.94317650
35	ICK	0.93698491
36	TEC	0.88903580
37	PLK3	0.88851060
38	RPS6KA6	0.88641381
39	TRIM28	0.85794355
40	PRKCG	0.84549425
41	CDC7	0.84437701
42	MARK3	0.82147460
43	ATR	0.81830858
44	MKNK1	0.78366565
45	CSNK1E	0.78104415
46	MINK1	0.77987630
47	CAMK1D	0.77486809
48	PIK3CA	0.76724309
49	WNK1	0.73563237
50	BTK	0.73516743
51	RPS6KC1	0.73155791
52	RPS6KL1	0.73155791
53	SGK223	0.72894387
54	SGK494	0.72894387
55	SIK3	0.72711222
56	MKNK2	0.71846117
57	PASK	0.70856770
58	CSNK1G2	0.70323298
59	IKBKE	0.69850153
60	MAP2K6	0.68221926
61	MAP2K7	0.66708028
62	DAPK3	0.66120637
63	ITK	0.65358250
64	BRAF	0.65022059
65	VRK2	0.64800598
66	RPS6KA5	0.64470128
67	GRK5	0.61864412
68	CSNK2A2	0.61856709
69	MAP3K4	0.60727054
70	FGFR4	0.57895321
71	ADRBK1	0.57475529
72	CSNK1G3	0.56817709
73	CAMK1	0.56680976
74	NEK2	0.56655933
75	AURKB	0.56517136
76	IRAK1	0.54101826
77	SGK2	0.53933798
78	PRKACA	0.53883816
79	NME1	0.48907799
80	MAP3K11	0.47443622
81	PIM1	0.47336129
82	CSNK2A1	0.47038449
83	JAK3	0.47004290
84	MAPK15	0.45565200
85	CSNK1A1L	0.45245934
86	FRK	0.44967182
87	INSRR	0.44074814
88	CAMK2A	0.43943788
89	NME2	0.42429199
90	STK11	0.42383299
91	NTRK2	0.41827890
92	LRRK2	0.41216324
93	ATM	0.40863522
94	PIM2	0.39753138
95	DYRK1B	0.39649345
96	OXSR1	0.39232424
97	CSNK1G1	0.38522563
98	CAMK4	0.38252530
99	PLK1	0.37281266
100	PRKCA	0.36664477

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.86856965
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.44924962
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.40676866
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.08931898
5	Parkinsons disease_Homo sapiens_hsa05012	2.83874106
6	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.23139971
7	Basal transcription factors_Homo sapiens_hsa03022	2.19692088
8	Huntingtons disease_Homo sapiens_hsa05016	2.08825099
9	One carbon pool by folate_Homo sapiens_hsa00670	2.07956977
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.05642660
11	RNA polymerase_Homo sapiens_hsa03020	2.05261864
12	Proteasome_Homo sapiens_hsa03050	1.99342307
13	RNA degradation_Homo sapiens_hsa03018	1.85937827
14	Phototransduction_Homo sapiens_hsa04744	1.84601434
15	Protein export_Homo sapiens_hsa03060	1.80369011
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.78621770
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.75132959
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.70849398
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.65533120
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.64398493
21	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.63379882
22	Alzheimers disease_Homo sapiens_hsa05010	1.55072932
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.54646546
24	Sulfur relay system_Homo sapiens_hsa04122	1.50568369
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.45486938
26	Nicotine addiction_Homo sapiens_hsa05033	1.45250800
27	Asthma_Homo sapiens_hsa05310	1.43741739
28	Caffeine metabolism_Homo sapiens_hsa00232	1.27480151
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.26114603
30	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.22638482
31	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.22350631
32	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.16378369
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.15174049
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.07927842
35	Olfactory transduction_Homo sapiens_hsa04740	1.03225698
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.99770135
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.98209250
38	Fanconi anemia pathway_Homo sapiens_hsa03460	0.97281681
39	Spliceosome_Homo sapiens_hsa03040	0.96180151
40	Butanoate metabolism_Homo sapiens_hsa00650	0.94550924
41	Base excision repair_Homo sapiens_hsa03410	0.93462992
42	Fat digestion and absorption_Homo sapiens_hsa04975	0.93010498
43	Morphine addiction_Homo sapiens_hsa05032	0.91858904
44	Arginine and proline metabolism_Homo sapiens_hsa00330	0.91048160
45	Purine metabolism_Homo sapiens_hsa00230	0.90823008
46	Type I diabetes mellitus_Homo sapiens_hsa04940	0.89752245
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86177999
48	Peroxisome_Homo sapiens_hsa04146	0.85312434
49	Primary immunodeficiency_Homo sapiens_hsa05340	0.84918551
50	Nitrogen metabolism_Homo sapiens_hsa00910	0.84560734
51	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.81890327
52	Allograft rejection_Homo sapiens_hsa05330	0.78819880
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78171876
54	p53 signaling pathway_Homo sapiens_hsa04115	0.76438076
55	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.74597040
56	RNA transport_Homo sapiens_hsa03013	0.71687439
57	Mismatch repair_Homo sapiens_hsa03430	0.71197734
58	Tryptophan metabolism_Homo sapiens_hsa00380	0.71157896
59	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.70227252
60	Ether lipid metabolism_Homo sapiens_hsa00565	0.69985626
61	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.69856407
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.68768876
63	Metabolic pathways_Homo sapiens_hsa01100	0.67069054
64	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.66715022
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.64991018
66	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.64430232
67	Retinol metabolism_Homo sapiens_hsa00830	0.63858429
68	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.63733614
69	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.63690720
70	Steroid biosynthesis_Homo sapiens_hsa00100	0.63457800
71	Propanoate metabolism_Homo sapiens_hsa00640	0.63166757
72	DNA replication_Homo sapiens_hsa03030	0.61882800
73	Salivary secretion_Homo sapiens_hsa04970	0.61356676
74	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.60829779
75	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.60182105
76	Non-homologous end-joining_Homo sapiens_hsa03450	0.59887377
77	Regulation of autophagy_Homo sapiens_hsa04140	0.58951915
78	GABAergic synapse_Homo sapiens_hsa04727	0.55500218
79	Sulfur metabolism_Homo sapiens_hsa00920	0.55365824
80	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.54926051
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54296967
82	Selenocompound metabolism_Homo sapiens_hsa00450	0.53026664
83	Circadian entrainment_Homo sapiens_hsa04713	0.52955573
84	Fatty acid elongation_Homo sapiens_hsa00062	0.51930702
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.51851347
86	Insulin secretion_Homo sapiens_hsa04911	0.51187900
87	Homologous recombination_Homo sapiens_hsa03440	0.50933236
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50875658
89	Glutamatergic synapse_Homo sapiens_hsa04724	0.49145082
90	Tyrosine metabolism_Homo sapiens_hsa00350	0.45355692
91	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.45265116
92	Basal cell carcinoma_Homo sapiens_hsa05217	0.39115111
93	Phenylalanine metabolism_Homo sapiens_hsa00360	0.34760537
94	Galactose metabolism_Homo sapiens_hsa00052	0.34541710
95	Mineral absorption_Homo sapiens_hsa04978	0.33257754
96	Cocaine addiction_Homo sapiens_hsa05030	0.32573904
97	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.31942782
98	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.31588618
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.30455120
100	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.28641167

RPS20P21

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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