ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.14958345
2	protein complex biogenesis (GO:0070271)	4.03380405
3	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.91127313
4	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.86110519
5	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.83567431
6	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.83567431
7	NADH dehydrogenase complex assembly (GO:0010257)	3.83567431
8	mitochondrial respiratory chain complex assembly (GO:0033108)	3.83028908
9	L-fucose catabolic process (GO:0042355)	3.77832649
10	fucose catabolic process (GO:0019317)	3.77832649
11	L-fucose metabolic process (GO:0042354)	3.77832649
12	water-soluble vitamin biosynthetic process (GO:0042364)	3.77633079
13	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.66786607
14	negative regulation of telomere maintenance (GO:0032205)	3.56857090
15	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.50943786
16	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.47613071
17	replication fork processing (GO:0031297)	3.47116550
18	respiratory chain complex IV assembly (GO:0008535)	3.43111271
19	response to pheromone (GO:0019236)	3.42655620
20	DNA deamination (GO:0045006)	3.29153902
21	cytochrome complex assembly (GO:0017004)	3.26494331
22	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.26489170
23	platelet dense granule organization (GO:0060155)	3.19714588
24	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.11181287
25	ATP synthesis coupled proton transport (GO:0015986)	3.11181287
26	nonmotile primary cilium assembly (GO:0035058)	3.09534503
27	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.09208524
28	regulation of hexokinase activity (GO:1903299)	3.06033793
29	regulation of glucokinase activity (GO:0033131)	3.06033793
30	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.00830796
31	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.99315382
32	cellular ketone body metabolic process (GO:0046950)	2.97023999
33	piRNA metabolic process (GO:0034587)	2.95593342
34	DNA double-strand break processing (GO:0000729)	2.90864607
35	protein K11-linked deubiquitination (GO:0035871)	2.88303960
36	recombinational repair (GO:0000725)	2.87570423
37	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.86713622
38	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.86713622
39	epithelial cilium movement (GO:0003351)	2.85223841
40	regulation of posttranscriptional gene silencing (GO:0060147)	2.85072112
41	regulation of gene silencing by miRNA (GO:0060964)	2.85072112
42	regulation of gene silencing by RNA (GO:0060966)	2.85072112
43	double-strand break repair via homologous recombination (GO:0000724)	2.84495787
44	protein K6-linked ubiquitination (GO:0085020)	2.83453070
45	indole-containing compound catabolic process (GO:0042436)	2.80655801
46	indolalkylamine catabolic process (GO:0046218)	2.80655801
47	tryptophan catabolic process (GO:0006569)	2.80655801
48	axoneme assembly (GO:0035082)	2.79374910
49	protein neddylation (GO:0045116)	2.78727756
50	protein-cofactor linkage (GO:0018065)	2.77656704
51	ubiquinone biosynthetic process (GO:0006744)	2.77001299
52	glycerophospholipid catabolic process (GO:0046475)	2.76072146
53	protein polyglutamylation (GO:0018095)	2.74300073
54	somite development (GO:0061053)	2.72292700
55	regulation of telomere maintenance (GO:0032204)	2.71684577
56	termination of RNA polymerase III transcription (GO:0006386)	2.69895697
57	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.69895697
58	ubiquinone metabolic process (GO:0006743)	2.69622763
59	indolalkylamine metabolic process (GO:0006586)	2.69471962
60	ketone body metabolic process (GO:1902224)	2.68867509
61	regulation of cilium movement (GO:0003352)	2.66629003
62	photoreceptor cell maintenance (GO:0045494)	2.66438464
63	synapsis (GO:0007129)	2.66336320
64	kidney morphogenesis (GO:0060993)	2.64963734
65	kynurenine metabolic process (GO:0070189)	2.64943422
66	sulfation (GO:0051923)	2.64927871
67	protein localization to cilium (GO:0061512)	2.64710562
68	resolution of meiotic recombination intermediates (GO:0000712)	2.64326069
69	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.62712486
70	cilium morphogenesis (GO:0060271)	2.61986110
71	reciprocal meiotic recombination (GO:0007131)	2.61960591
72	reciprocal DNA recombination (GO:0035825)	2.61960591
73	otic vesicle formation (GO:0030916)	2.59529663
74	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.58609256
75	regulation of translation, ncRNA-mediated (GO:0045974)	2.58609256
76	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.58609256
77	mannosylation (GO:0097502)	2.57596938
78	rRNA catabolic process (GO:0016075)	2.57338477
79	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.56686053
80	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.56686053
81	intracellular protein transmembrane import (GO:0044743)	2.56623855
82	nephron epithelium morphogenesis (GO:0072088)	2.56590997
83	nephron tubule morphogenesis (GO:0072078)	2.56590997
84	presynaptic membrane assembly (GO:0097105)	2.56522672
85	pyrimidine nucleobase catabolic process (GO:0006208)	2.55445647
86	regulation of mitotic spindle checkpoint (GO:1903504)	2.55118159
87	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.55118159
88	electron transport chain (GO:0022900)	2.52696538
89	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.52408528
90	cilium organization (GO:0044782)	2.52143652
91	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.51640698
92	chromatin remodeling at centromere (GO:0031055)	2.51608643
93	male meiosis I (GO:0007141)	2.50102027
94	intraciliary transport (GO:0042073)	2.48454669
95	dopamine transport (GO:0015872)	2.47933929
96	meiotic chromosome segregation (GO:0045132)	2.46537957
97	respiratory electron transport chain (GO:0022904)	2.46304291
98	detection of light stimulus involved in sensory perception (GO:0050962)	2.43942231
99	detection of light stimulus involved in visual perception (GO:0050908)	2.43942231
100	pseudouridine synthesis (GO:0001522)	2.43867587

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.89349800
2	VDR_22108803_ChIP-Seq_LS180_Human	3.24050425
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.03504387
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.87137241
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.84250315
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.67677319
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.57115697
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.49814488
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.42748393
10	FUS_26573619_Chip-Seq_HEK293_Human	2.38619779
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.32001708
12	EWS_26573619_Chip-Seq_HEK293_Human	2.28864127
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.26811428
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.24149049
15	IGF1R_20145208_ChIP-Seq_DFB_Human	2.23286625
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.12033379
17	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.06041324
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.01763432
19	TAF15_26573619_Chip-Seq_HEK293_Human	2.00848648
20	P300_19829295_ChIP-Seq_ESCs_Human	1.98051301
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97810964
22	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.96071695
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.88633963
24	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.81328560
25	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.80927365
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.77809834
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.71346695
28	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.71262303
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.69433885
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.66157078
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.62105729
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.60971317
33	BCAT_22108803_ChIP-Seq_LS180_Human	1.59599891
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.59547950
35	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.59356777
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55054318
37	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.51314072
38	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.48305484
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.46023752
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.41692367
41	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.40555859
42	AR_25329375_ChIP-Seq_VCAP_Human	1.37752848
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.36368655
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.36368655
45	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.34415084
46	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.33309651
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.32106024
48	VDR_23849224_ChIP-Seq_CD4+_Human	1.31696076
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30657375
50	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.30088134
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.29835959
52	STAT3_23295773_ChIP-Seq_U87_Human	1.29488260
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29423585
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29423585
55	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.29352089
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.28377533
57	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26868131
58	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.26868131
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26536873
60	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.23829617
61	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.23364273
62	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.23235401
63	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21764527
64	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21700584
65	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.21511252
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.21019886
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20087085
68	TCF4_23295773_ChIP-Seq_U87_Human	1.19969988
69	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19365071
70	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.19335737
71	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.18879859
72	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.18879859
73	RNF2_27304074_Chip-Seq_NSC_Mouse	1.18069427
74	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.17823936
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17647211
76	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16806540
77	REST_21632747_ChIP-Seq_MESCs_Mouse	1.14813457
78	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.14766497
79	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.13858739
80	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.11959980
81	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.08014529
82	NCOR_22424771_ChIP-Seq_293T_Human	1.06794849
83	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06486745
84	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.05947103
85	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.04663562
86	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04432600
87	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04393322
88	AR_21572438_ChIP-Seq_LNCaP_Human	1.03000196
89	AR_20517297_ChIP-Seq_VCAP_Human	1.02659450
90	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.02654712
91	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.00915305
92	FOXP3_21729870_ChIP-Seq_TREG_Human	0.97524503
93	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.97195273
94	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.96864493
95	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.95967502
96	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.93699089
97	CDX2_22108803_ChIP-Seq_LS180_Human	0.92654563
98	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.91953247
99	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.91576271
100	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.91131013

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.24881454
2	MP0006292_abnormal_olfactory_placode	2.95479053
3	MP0003136_yellow_coat_color	2.67508430
4	MP0002102_abnormal_ear_morphology	2.44671620
5	MP0003880_abnormal_central_pattern	2.37206962
6	MP0003195_calcinosis	2.34352568
7	MP0005551_abnormal_eye_electrophysiolog	2.26777885
8	MP0003787_abnormal_imprinting	2.22267328
9	MP0002837_dystrophic_cardiac_calcinosis	2.13396977
10	MP0001968_abnormal_touch/_nociception	2.09390521
11	MP0002938_white_spotting	2.06938832
12	MP0006072_abnormal_retinal_apoptosis	2.06050144
13	MP0002736_abnormal_nociception_after	1.97234310
14	MP0004133_heterotaxia	1.95406585
15	MP0003646_muscle_fatigue	1.89380542
16	MP0001485_abnormal_pinna_reflex	1.87677176
17	MP0004142_abnormal_muscle_tone	1.77335972
18	MP0003011_delayed_dark_adaptation	1.70640992
19	MP0004885_abnormal_endolymph	1.64655356
20	MP0002163_abnormal_gland_morphology	1.63452445
21	MP0009745_abnormal_behavioral_response	1.63216320
22	MP0006276_abnormal_autonomic_nervous	1.62566553
23	MP0008875_abnormal_xenobiotic_pharmacok	1.62487384
24	MP0008872_abnormal_physiological_respon	1.62103863
25	MP0009046_muscle_twitch	1.62001001
26	MP0003890_abnormal_embryonic-extraembry	1.61758103
27	MP0002653_abnormal_ependyma_morphology	1.60380117
28	MP0002876_abnormal_thyroid_physiology	1.60020682
29	MP0002254_reproductive_system_inflammat	1.57503096
30	MP0005253_abnormal_eye_physiology	1.57402136
31	MP0001529_abnormal_vocalization	1.53478856
32	MP0004147_increased_porphyrin_level	1.53279088
33	MP0000631_abnormal_neuroendocrine_gland	1.51629154
34	MP0000569_abnormal_digit_pigmentation	1.50683223
35	MP0008058_abnormal_DNA_repair	1.45773539
36	MP0009379_abnormal_foot_pigmentation	1.45721676
37	MP0001984_abnormal_olfaction	1.45279584
38	MP0000372_irregular_coat_pigmentation	1.45099171
39	MP0002272_abnormal_nervous_system	1.43838592
40	MP0002638_abnormal_pupillary_reflex	1.42599622
41	MP0005174_abnormal_tail_pigmentation	1.42065174
42	MP0000427_abnormal_hair_cycle	1.41489807
43	MP0005084_abnormal_gallbladder_morpholo	1.39929120
44	MP0002160_abnormal_reproductive_system	1.37751260
45	MP0003718_maternal_effect	1.36556882
46	MP0001293_anophthalmia	1.36196582
47	MP0001986_abnormal_taste_sensitivity	1.28469142
48	MP0003121_genomic_imprinting	1.27768983
49	MP0003937_abnormal_limbs/digits/tail_de	1.26948558
50	MP0005646_abnormal_pituitary_gland	1.25262627
51	MP0001486_abnormal_startle_reflex	1.23507003
52	MP0005389_reproductive_system_phenotype	1.22371654
53	MP0003122_maternal_imprinting	1.22070822
54	MP0005379_endocrine/exocrine_gland_phen	1.19329259
55	MP0004043_abnormal_pH_regulation	1.17209684
56	MP0001501_abnormal_sleep_pattern	1.17179290
57	MP0002277_abnormal_respiratory_mucosa	1.14206225
58	MP0001188_hyperpigmentation	1.13693491
59	MP0004742_abnormal_vestibular_system	1.13406937
60	MP0002557_abnormal_social/conspecific_i	1.13342549
61	MP0008057_abnormal_DNA_replication	1.11505982
62	MP0000778_abnormal_nervous_system	1.10855229
63	MP0002735_abnormal_chemical_nociception	1.10230068
64	MP0002064_seizures	1.07788601
65	MP0000049_abnormal_middle_ear	1.07427103
66	MP0005645_abnormal_hypothalamus_physiol	1.05742268
67	MP0002572_abnormal_emotion/affect_behav	1.03121827
68	MP0008995_early_reproductive_senescence	1.02358234
69	MP0005195_abnormal_posterior_eye	1.01727590
70	MP0002210_abnormal_sex_determination	1.01505516
71	MP0002751_abnormal_autonomic_nervous	1.00686278
72	MP0008789_abnormal_olfactory_epithelium	1.00676179
73	MP0001970_abnormal_pain_threshold	0.94618708
74	MP0000647_abnormal_sebaceous_gland	0.94376014
75	MP0003119_abnormal_digestive_system	0.94070045
76	MP0001929_abnormal_gametogenesis	0.93004325
77	MP0002067_abnormal_sensory_capabilities	0.92603184
78	MP0001502_abnormal_circadian_rhythm	0.89052406
79	MP0005423_abnormal_somatic_nervous	0.88977048
80	MP0002234_abnormal_pharynx_morphology	0.88572897
81	MP0002095_abnormal_skin_pigmentation	0.88336046
82	MP0002752_abnormal_somatic_nervous	0.88215054
83	MP0003698_abnormal_male_reproductive	0.88123235
84	MP0000026_abnormal_inner_ear	0.86989279
85	MP0000653_abnormal_sex_gland	0.86666862
86	MP0003567_abnormal_fetal_cardiomyocyte	0.85276872
87	MP0010386_abnormal_urinary_bladder	0.84811812
88	MP0001324_abnormal_eye_pigmentation	0.84443351
89	MP0002733_abnormal_thermal_nociception	0.84222105
90	MP0001963_abnormal_hearing_physiology	0.84125280
91	MP0010030_abnormal_orbit_morphology	0.83329208
92	MP0002734_abnormal_mechanical_nocicepti	0.83288703
93	MP0001905_abnormal_dopamine_level	0.83066902
94	MP0000383_abnormal_hair_follicle	0.82929462
95	MP0001145_abnormal_male_reproductive	0.82474172
96	MP0001919_abnormal_reproductive_system	0.82458862
97	MP0003938_abnormal_ear_development	0.81800306
98	MP0006035_abnormal_mitochondrial_morpho	0.81636196
99	MP0005377_hearing/vestibular/ear_phenot	0.80378830
100	MP0003878_abnormal_ear_physiology	0.80378830

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.35869124
2	Pancreatic fibrosis (HP:0100732)	4.19500328
3	True hermaphroditism (HP:0010459)	4.11081945
4	Abnormality of midbrain morphology (HP:0002418)	4.05861450
5	Molar tooth sign on MRI (HP:0002419)	4.05861450
6	Nephronophthisis (HP:0000090)	3.18503109
7	Acute necrotizing encephalopathy (HP:0006965)	2.92568829
8	Congenital stationary night blindness (HP:0007642)	2.82075871
9	Abnormality of the renal medulla (HP:0100957)	2.77099120
10	Chronic hepatic failure (HP:0100626)	2.77010634
11	Abnormality of the labia minora (HP:0012880)	2.72550168
12	Medial flaring of the eyebrow (HP:0010747)	2.67742660
13	Bile duct proliferation (HP:0001408)	2.65490322
14	Abnormal biliary tract physiology (HP:0012439)	2.65490322
15	Cystic liver disease (HP:0006706)	2.65485192
16	Acute encephalopathy (HP:0006846)	2.65123104
17	Mitochondrial inheritance (HP:0001427)	2.59835070
18	Type II lissencephaly (HP:0007260)	2.59383698
19	Pendular nystagmus (HP:0012043)	2.58630485
20	Colon cancer (HP:0003003)	2.57259431
21	Abolished electroretinogram (ERG) (HP:0000550)	2.55132693
22	Tubular atrophy (HP:0000092)	2.54495083
23	Progressive macrocephaly (HP:0004481)	2.52584008
24	Sclerocornea (HP:0000647)	2.49784003
25	Meckel diverticulum (HP:0002245)	2.48230089
26	Abnormality of the ileum (HP:0001549)	2.48000516
27	Septo-optic dysplasia (HP:0100842)	2.47657371
28	Abnormality of the renal cortex (HP:0011035)	2.46730582
29	Increased CSF lactate (HP:0002490)	2.45481185
30	Abnormal mitochondria in muscle tissue (HP:0008316)	2.42125635
31	Abnormal number of erythroid precursors (HP:0012131)	2.41286606
32	Anencephaly (HP:0002323)	2.40503242
33	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.39731432
34	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.38166558
35	Attenuation of retinal blood vessels (HP:0007843)	2.37752840
36	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.34678048
37	Congenital, generalized hypertrichosis (HP:0004540)	2.32712190
38	Abnormality of alanine metabolism (HP:0010916)	2.32672003
39	Hyperalaninemia (HP:0003348)	2.32672003
40	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.32672003
41	Optic nerve hypoplasia (HP:0000609)	2.32589396
42	Inability to walk (HP:0002540)	2.29073504
43	Hyperventilation (HP:0002883)	2.28103547
44	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.25820470
45	Increased hepatocellular lipid droplets (HP:0006565)	2.24739445
46	Lipid accumulation in hepatocytes (HP:0006561)	2.21936709
47	Polydipsia (HP:0001959)	2.21489847
48	Abnormal drinking behavior (HP:0030082)	2.21489847
49	Male pseudohermaphroditism (HP:0000037)	2.16598153
50	Large for gestational age (HP:0001520)	2.15293301
51	Abnormality of the pons (HP:0007361)	2.14260233
52	Reticulocytopenia (HP:0001896)	2.12360831
53	Duplicated collecting system (HP:0000081)	2.12062460
54	Abnormality of the renal collecting system (HP:0004742)	2.11705697
55	Gait imbalance (HP:0002141)	2.11672125
56	Chromsome breakage (HP:0040012)	2.10885030
57	Optic disc pallor (HP:0000543)	2.09417119
58	Congenital primary aphakia (HP:0007707)	2.09013712
59	Intestinal atresia (HP:0011100)	2.07571589
60	Genital tract atresia (HP:0001827)	2.07439915
61	Absent thumb (HP:0009777)	2.07170806
62	Hyperglycinuria (HP:0003108)	2.05992560
63	Hypoplasia of the pons (HP:0012110)	2.05927320
64	Cerebellar dysplasia (HP:0007033)	2.05290198
65	Vaginal atresia (HP:0000148)	2.04817425
66	Abnormality of cells of the erythroid lineage (HP:0012130)	2.03609550
67	Postaxial foot polydactyly (HP:0001830)	2.03479323
68	Nephrogenic diabetes insipidus (HP:0009806)	2.00725922
69	Progressive inability to walk (HP:0002505)	2.00120991
70	Furrowed tongue (HP:0000221)	1.97828157
71	Lissencephaly (HP:0001339)	1.97155957
72	Hepatocellular necrosis (HP:0001404)	1.96204609
73	Abnormal rod and cone electroretinograms (HP:0008323)	1.96023064
74	Increased corneal curvature (HP:0100692)	1.94200724
75	Keratoconus (HP:0000563)	1.94200724
76	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.93926810
77	Congenital hepatic fibrosis (HP:0002612)	1.93609201
78	Methylmalonic acidemia (HP:0002912)	1.89192908
79	Triphalangeal thumb (HP:0001199)	1.88489706
80	Preaxial hand polydactyly (HP:0001177)	1.87971716
81	Concave nail (HP:0001598)	1.87417141
82	Abnormality of chromosome stability (HP:0003220)	1.86053618
83	Ectopic kidney (HP:0000086)	1.85605075
84	Decreased central vision (HP:0007663)	1.84228721
85	3-Methylglutaconic aciduria (HP:0003535)	1.84021064
86	Dandy-Walker malformation (HP:0001305)	1.83247331
87	Abnormality of DNA repair (HP:0003254)	1.81427842
88	Polyuria (HP:0000103)	1.79866234
89	Gaze-evoked nystagmus (HP:0000640)	1.79681893
90	Renal Fanconi syndrome (HP:0001994)	1.79173966
91	Sloping forehead (HP:0000340)	1.78782822
92	Hyperglycinemia (HP:0002154)	1.78283018
93	Anophthalmia (HP:0000528)	1.75885549
94	Postaxial hand polydactyly (HP:0001162)	1.74687419
95	Hepatic necrosis (HP:0002605)	1.73977085
96	Broad-based gait (HP:0002136)	1.71599325
97	Clubbing of toes (HP:0100760)	1.71384212
98	Small hand (HP:0200055)	1.69286606
99	Cerebral edema (HP:0002181)	1.69027094
100	Abnormality of glycine metabolism (HP:0010895)	1.68680067

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.30571401
2	ADRBK2	3.06320407
3	ZAK	3.01159546
4	WNK3	2.84418849
5	BMPR1B	2.78765015
6	NUAK1	2.68317284
7	MAP4K2	2.66305880
8	TNIK	2.64030481
9	WNK4	2.56777771
10	ACVR1B	2.35716149
11	GRK1	2.19269092
12	MKNK2	2.16092527
13	PINK1	2.05706566
14	INSRR	1.96020562
15	STK39	1.92392153
16	VRK2	1.89282692
17	STK16	1.78260856
18	CASK	1.74644942
19	OXSR1	1.71083764
20	BRSK2	1.63236239
21	TLK1	1.62976826
22	TRIM28	1.60657986
23	VRK1	1.55849430
24	MST4	1.53527099
25	MAP3K4	1.51408146
26	DYRK2	1.47666132
27	PNCK	1.46836606
28	TAF1	1.45270005
29	MAPK13	1.37747384
30	MKNK1	1.35213844
31	DAPK2	1.27194097
32	FGFR2	1.18378464
33	PLK3	1.17389492
34	CDC7	1.12988052
35	PAK3	1.07932268
36	EPHA4	1.03988301
37	ADRBK1	0.98516194
38	PRKCG	0.96379209
39	PRKCE	0.95070273
40	TGFBR1	0.94908679
41	STK38L	0.92271032
42	NME1	0.91035886
43	PLK4	0.90566231
44	PLK2	0.90394700
45	CSNK1G1	0.86410523
46	CAMKK2	0.85050488
47	EIF2AK3	0.84683527
48	NLK	0.84327799
49	MAP2K7	0.84143788
50	BCKDK	0.83836944
51	CSNK1G2	0.79797303
52	PLK1	0.76654645
53	WEE1	0.75068553
54	TIE1	0.73655391
55	PIK3CA	0.72524516
56	CSNK1G3	0.60082225
57	STK3	0.60051611
58	CHEK2	0.59046139
59	TXK	0.56554686
60	CAMK1	0.56549240
61	PTK2B	0.54808754
62	BUB1	0.53757363
63	BCR	0.53681976
64	RPS6KA5	0.53518089
65	ATR	0.50634194
66	TSSK6	0.50474630
67	TTK	0.49570991
68	CDK19	0.49434978
69	PRKCQ	0.49269718
70	CAMK1G	0.49188844
71	MARK1	0.49031285
72	FLT3	0.48902696
73	TAOK3	0.47779969
74	MUSK	0.47621013
75	PHKG1	0.46994428
76	PHKG2	0.46994428
77	PBK	0.46068995
78	IRAK1	0.44106365
79	CSNK1A1	0.43871521
80	AKT3	0.43255198
81	NTRK2	0.41783243
82	FER	0.41768271
83	PRKACA	0.41062186
84	STK11	0.40916500
85	CAMK2A	0.40312580
86	NTRK3	0.40210079
87	BRSK1	0.40036906
88	SRPK1	0.40002908
89	PKN1	0.39042633
90	PRKCI	0.38968365
91	CSNK1A1L	0.38636552
92	TEC	0.35677781
93	MAPK15	0.34539006
94	DYRK1A	0.33939969
95	ATM	0.32899820
96	PASK	0.31057312
97	CAMK1D	0.31014759
98	MAPKAPK5	0.30318217
99	NEK2	0.29713155
100	ERBB3	0.29066275

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.03777919
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.76739378
3	Homologous recombination_Homo sapiens_hsa03440	2.56234596
4	RNA polymerase_Homo sapiens_hsa03020	2.53120324
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.44425832
6	Parkinsons disease_Homo sapiens_hsa05012	2.41697931
7	Protein export_Homo sapiens_hsa03060	2.35637159
8	Phototransduction_Homo sapiens_hsa04744	2.23620820
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.22106621
10	Butanoate metabolism_Homo sapiens_hsa00650	2.16661228
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.05626794
12	Ribosome_Homo sapiens_hsa03010	2.01026602
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.96680275
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.94365609
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.92472187
16	Basal transcription factors_Homo sapiens_hsa03022	1.85874327
17	Huntingtons disease_Homo sapiens_hsa05016	1.80199346
18	Propanoate metabolism_Homo sapiens_hsa00640	1.78306799
19	Proteasome_Homo sapiens_hsa03050	1.76466014
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.71135173
21	RNA degradation_Homo sapiens_hsa03018	1.70720313
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.66285594
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.57255600
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.56459054
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.55034331
26	One carbon pool by folate_Homo sapiens_hsa00670	1.53683943
27	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.52611292
28	Alzheimers disease_Homo sapiens_hsa05010	1.52173656
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.50897775
30	Nicotine addiction_Homo sapiens_hsa05033	1.47406040
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.42617605
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.41722768
33	Mismatch repair_Homo sapiens_hsa03430	1.38546572
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.36799577
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.36235064
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.26239437
37	Steroid biosynthesis_Homo sapiens_hsa00100	1.26191840
38	Peroxisome_Homo sapiens_hsa04146	1.24666058
39	Non-homologous end-joining_Homo sapiens_hsa03450	1.23199068
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.18539871
41	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.14007680
42	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.10430686
43	Caffeine metabolism_Homo sapiens_hsa00232	1.09684193
44	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01114293
45	Olfactory transduction_Homo sapiens_hsa04740	0.99533597
46	Nucleotide excision repair_Homo sapiens_hsa03420	0.98685620
47	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.98409483
48	Retinol metabolism_Homo sapiens_hsa00830	0.95548192
49	Purine metabolism_Homo sapiens_hsa00230	0.95022058
50	Taste transduction_Homo sapiens_hsa04742	0.93366681
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.89458651
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.88360839
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.86200718
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.85308939
55	RNA transport_Homo sapiens_hsa03013	0.85188223
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84706086
57	Pyrimidine metabolism_Homo sapiens_hsa00240	0.82078723
58	Regulation of autophagy_Homo sapiens_hsa04140	0.80593899
59	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.78910283
60	DNA replication_Homo sapiens_hsa03030	0.76867272
61	Metabolic pathways_Homo sapiens_hsa01100	0.76634303
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.76010734
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.75845240
64	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.73790817
65	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.73474305
66	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.73406834
67	Base excision repair_Homo sapiens_hsa03410	0.73099687
68	Morphine addiction_Homo sapiens_hsa05032	0.71127428
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70692041
70	Pyruvate metabolism_Homo sapiens_hsa00620	0.68502499
71	Basal cell carcinoma_Homo sapiens_hsa05217	0.68445095
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.64613152
73	Insulin secretion_Homo sapiens_hsa04911	0.64554137
74	Histidine metabolism_Homo sapiens_hsa00340	0.62154481
75	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.61299625
76	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.60460374
77	Serotonergic synapse_Homo sapiens_hsa04726	0.60396186
78	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.60145201
79	Fatty acid elongation_Homo sapiens_hsa00062	0.58585874
80	ABC transporters_Homo sapiens_hsa02010	0.57045298
81	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.56334230
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.56169249
83	Spliceosome_Homo sapiens_hsa03040	0.55075060
84	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.54264590
85	Collecting duct acid secretion_Homo sapiens_hsa04966	0.52500935
86	GABAergic synapse_Homo sapiens_hsa04727	0.52500633
87	Glutamatergic synapse_Homo sapiens_hsa04724	0.51670845
88	Fatty acid degradation_Homo sapiens_hsa00071	0.51323159
89	Glutathione metabolism_Homo sapiens_hsa00480	0.51322395
90	Circadian entrainment_Homo sapiens_hsa04713	0.45764778
91	Circadian rhythm_Homo sapiens_hsa04710	0.45365114
92	Folate biosynthesis_Homo sapiens_hsa00790	0.44997674
93	Mineral absorption_Homo sapiens_hsa04978	0.42074300
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.42068388
95	Sulfur relay system_Homo sapiens_hsa04122	0.41269498
96	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.40234500
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.37532774
98	Calcium signaling pathway_Homo sapiens_hsa04020	0.36978723
99	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.35018232
100	Salivary secretion_Homo sapiens_hsa04970	0.34464222

RPS20P22

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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