ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.79862497
2	translational termination (GO:0006415)	8.40141418
3	ribosomal small subunit biogenesis (GO:0042274)	8.38856654
4	ribosomal small subunit assembly (GO:0000028)	7.77716514
5	maturation of SSU-rRNA (GO:0030490)	7.68675620
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.10526638
7	cotranslational protein targeting to membrane (GO:0006613)	7.01815993
8	translational elongation (GO:0006414)	6.98070256
9	protein targeting to ER (GO:0045047)	6.96781398
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.68260086
11	protein localization to endoplasmic reticulum (GO:0070972)	6.54286124
12	cellular protein complex disassembly (GO:0043624)	6.38303096
13	viral life cycle (GO:0019058)	6.32720235
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.16857018
15	behavioral response to nicotine (GO:0035095)	5.73031970
16	chaperone-mediated protein transport (GO:0072321)	5.69384718
17	protein complex disassembly (GO:0043241)	5.39997362
18	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.38653763
19	ATP synthesis coupled proton transport (GO:0015986)	5.38653763
20	translational initiation (GO:0006413)	5.30316746
21	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	5.29417932
22	macromolecular complex disassembly (GO:0032984)	5.16143040
23	ribosomal large subunit biogenesis (GO:0042273)	5.02078175
24	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.86708002
25	protein targeting to membrane (GO:0006612)	4.82758037
26	pyrimidine nucleotide catabolic process (GO:0006244)	4.76241371
27	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.67257463
28	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.60060752
29	translation (GO:0006412)	4.21163000
30	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.18462433
31	substrate-independent telencephalic tangential migration (GO:0021826)	4.08115960
32	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.08115960
33	protein neddylation (GO:0045116)	4.04070565
34	respiratory electron transport chain (GO:0022904)	3.99610099
35	ribonucleoprotein complex biogenesis (GO:0022613)	3.96562611
36	electron transport chain (GO:0022900)	3.94493475
37	mRNA catabolic process (GO:0006402)	3.94375605
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.92428285
39	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.92428285
40	NADH dehydrogenase complex assembly (GO:0010257)	3.92428285
41	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.89861730
42	protein complex biogenesis (GO:0070271)	3.86578376
43	cellular component biogenesis (GO:0044085)	3.82249492
44	deoxyribonucleotide catabolic process (GO:0009264)	3.54212234
45	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.52853371
46	RNA catabolic process (GO:0006401)	3.51260836
47	behavioral response to ethanol (GO:0048149)	3.46570445
48	cell proliferation in forebrain (GO:0021846)	3.45991257
49	base-excision repair, AP site formation (GO:0006285)	3.44694767
50	mitochondrial respiratory chain complex assembly (GO:0033108)	3.39924732
51	establishment of protein localization to membrane (GO:0090150)	3.30260891
52	deoxyribose phosphate catabolic process (GO:0046386)	3.30077823
53	head development (GO:0060322)	3.26918482
54	axon ensheathment in central nervous system (GO:0032291)	3.26671037
55	central nervous system myelination (GO:0022010)	3.26671037
56	protein targeting (GO:0006605)	3.21738948
57	auditory receptor cell differentiation (GO:0042491)	3.18856544
58	pattern specification involved in kidney development (GO:0061004)	3.18041978
59	ATP biosynthetic process (GO:0006754)	3.02760636
60	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.99989669
61	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.99658222
62	neuron fate determination (GO:0048664)	2.98945496
63	positive regulation of T cell apoptotic process (GO:0070234)	2.98399915
64	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.95267649
65	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.95267649
66	cardiovascular system development (GO:0072358)	2.95244711
67	establishment of protein localization to organelle (GO:0072594)	2.93824651
68	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.93360112
69	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.91466764
70	GTP biosynthetic process (GO:0006183)	2.91214940
71	hypothalamus development (GO:0021854)	2.88393367
72	nonmotile primary cilium assembly (GO:0035058)	2.88296058
73	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.82997668
74	intracellular protein transmembrane import (GO:0044743)	2.80651131
75	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.78752386
76	synaptic transmission, cholinergic (GO:0007271)	2.77068302
77	regulation of cilium movement (GO:0003352)	2.74665795
78	genetic imprinting (GO:0071514)	2.74403103
79	establishment of mitochondrion localization (GO:0051654)	2.73922155
80	hydrogen ion transmembrane transport (GO:1902600)	2.72538193
81	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.68802579
82	mitochondrion transport along microtubule (GO:0047497)	2.68663657
83	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.68663657
84	protein localization to membrane (GO:0072657)	2.66494617
85	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.66076117
86	spinal cord association neuron differentiation (GO:0021527)	2.64106560
87	2-deoxyribonucleotide metabolic process (GO:0009394)	2.61999656
88	somite development (GO:0061053)	2.61788985
89	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.61506310
90	positive regulation of respiratory burst (GO:0060267)	2.61102103
91	rRNA processing (GO:0006364)	2.57920148
92	protein targeting to mitochondrion (GO:0006626)	2.55030688
93	parturition (GO:0007567)	2.55000011
94	segment specification (GO:0007379)	2.53888924
95	rRNA metabolic process (GO:0016072)	2.53140190
96	UTP biosynthetic process (GO:0006228)	2.50619736
97	UTP metabolic process (GO:0046051)	2.49830624
98	establishment of protein localization to mitochondrion (GO:0072655)	2.49436998
99	termination of RNA polymerase III transcription (GO:0006386)	2.48871863
100	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.48871863

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.60172349
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.42599539
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.22603792
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.91098146
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.57193558
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.54588451
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.54312264
8	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.45259011
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.30009200
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.23783256
11	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.14747747
12	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.06192499
13	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.03121737
14	VDR_22108803_ChIP-Seq_LS180_Human	2.02096491
15	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.91399989
16	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.90579916
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.89520168
18	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.88332423
19	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.86713287
20	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.79703504
21	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.79526690
22	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.68475594
23	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.68305031
24	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.67052277
25	XRN2_22483619_ChIP-Seq_HELA_Human	1.64575457
26	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.64461605
27	IRF1_19129219_ChIP-ChIP_H3396_Human	1.62965350
28	REST_21632747_ChIP-Seq_MESCs_Mouse	1.61872100
29	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.60854050
30	TTF2_22483619_ChIP-Seq_HELA_Human	1.58363983
31	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.50900994
32	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.50273678
33	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.49883474
34	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.48393301
35	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.47414179
36	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.47150705
37	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.46966743
38	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.45481611
39	ZNF274_21170338_ChIP-Seq_K562_Hela	1.44465980
40	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.41007805
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.40381017
42	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.40154694
43	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.39361000
44	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.38800732
45	GABP_19822575_ChIP-Seq_HepG2_Human	1.38082406
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36614810
47	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.35235511
48	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.35235511
49	VDR_23849224_ChIP-Seq_CD4+_Human	1.33067188
50	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.32470137
51	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.32405339
52	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.32285932
53	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.31775420
54	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.28267288
55	FOXP3_21729870_ChIP-Seq_TREG_Human	1.26959738
56	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.26151419
57	NANOG_20526341_ChIP-Seq_ESCs_Human	1.25157708
58	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.21818010
59	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.21723396
60	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.21286924
61	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.21055625
62	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.18445320
63	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.17911949
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17261380
65	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.14801069
66	TP53_22573176_ChIP-Seq_HFKS_Human	1.14673783
67	CTCF_27219007_Chip-Seq_Bcells_Human	1.13046010
68	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.12027870
69	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.11674991
70	RNF2_27304074_Chip-Seq_NSC_Mouse	1.11092525
71	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.09888314
72	ERA_21632823_ChIP-Seq_H3396_Human	1.09088062
73	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.08920981
74	BCL6_27268052_Chip-Seq_Bcells_Human	1.08368886
75	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.07454764
76	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.07181308
77	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.06984195
78	NCOR_22424771_ChIP-Seq_293T_Human	1.06676346
79	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.06592181
80	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06320497
81	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.06253145
82	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.05246372
83	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.02214067
84	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.01867645
85	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.01501671
86	STAT1_20625510_ChIP-Seq_HELA_Human	1.00784415
87	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.00647467
88	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.00126565
89	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99163085
90	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.97383287
91	CTCF_20526341_ChIP-Seq_ESCs_Human	0.96326147
92	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.95878584
93	ELK1_19687146_ChIP-ChIP_HELA_Human	0.95094864
94	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.92157979
95	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.90692438
96	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.90465976
97	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.89995430
98	P68_20966046_ChIP-Seq_HELA_Human	0.87482104
99	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.86737882
100	MYC_19829295_ChIP-Seq_ESCs_Human	0.86353486

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.56257997
2	MP0003787_abnormal_imprinting	4.89574964
3	MP0003123_paternal_imprinting	4.11764567
4	MP0006292_abnormal_olfactory_placode	4.08678446
5	MP0003122_maternal_imprinting	3.47721699
6	MP0003121_genomic_imprinting	2.68783810
7	MP0002163_abnormal_gland_morphology	2.61274542
8	MP0005646_abnormal_pituitary_gland	2.22150347
9	MP0008877_abnormal_DNA_methylation	2.16949707
10	MP0008789_abnormal_olfactory_epithelium	2.15444935
11	MP0002653_abnormal_ependyma_morphology	2.02534294
12	MP0005394_taste/olfaction_phenotype	1.90333841
13	MP0005499_abnormal_olfactory_system	1.90333841
14	MP0005423_abnormal_somatic_nervous	1.85325332
15	MP0004142_abnormal_muscle_tone	1.83742535
16	MP0006276_abnormal_autonomic_nervous	1.82189599
17	MP0001968_abnormal_touch/_nociception	1.76936153
18	MP0005379_endocrine/exocrine_gland_phen	1.74411246
19	MP0002736_abnormal_nociception_after	1.74376156
20	MP0004145_abnormal_muscle_electrophysio	1.64016784
21	MP0001293_anophthalmia	1.61557360
22	MP0000778_abnormal_nervous_system	1.60563701
23	MP0005360_urolithiasis	1.59134547
24	MP0001440_abnormal_grooming_behavior	1.56605121
25	MP0001984_abnormal_olfaction	1.55279258
26	MP0000631_abnormal_neuroendocrine_gland	1.49895591
27	MP0003646_muscle_fatigue	1.49889465
28	MP0005377_hearing/vestibular/ear_phenot	1.44962242
29	MP0003878_abnormal_ear_physiology	1.44962242
30	MP0002837_dystrophic_cardiac_calcinosis	1.43782836
31	MP0001188_hyperpigmentation	1.42753000
32	MP0001529_abnormal_vocalization	1.41703752
33	MP0000049_abnormal_middle_ear	1.39331834
34	MP0004133_heterotaxia	1.30314863
35	MP0002557_abnormal_social/conspecific_i	1.27933221
36	MP0002638_abnormal_pupillary_reflex	1.26666679
37	MP0004147_increased_porphyrin_level	1.25916367
38	MP0005670_abnormal_white_adipose	1.23759901
39	MP0003186_abnormal_redox_activity	1.23303763
40	MP0004885_abnormal_endolymph	1.22532832
41	MP0003136_yellow_coat_color	1.22325233
42	MP0001905_abnormal_dopamine_level	1.20889418
43	MP0002733_abnormal_thermal_nociception	1.19296188
44	MP0003938_abnormal_ear_development	1.18696270
45	MP0003879_abnormal_hair_cell	1.18388806
46	MP0002234_abnormal_pharynx_morphology	1.18223070
47	MP0002272_abnormal_nervous_system	1.18066117
48	MP0001970_abnormal_pain_threshold	1.14563132
49	MP0009745_abnormal_behavioral_response	1.13971554
50	MP0010030_abnormal_orbit_morphology	1.13016171
51	MP0005084_abnormal_gallbladder_morpholo	1.12601019
52	MP0002184_abnormal_innervation	1.12495591
53	MP0005551_abnormal_eye_electrophysiolog	1.09716581
54	MP0002102_abnormal_ear_morphology	1.08734727
55	MP0002572_abnormal_emotion/affect_behav	1.08617602
56	MP0005195_abnormal_posterior_eye	1.08358265
57	MP0002938_white_spotting	1.08184347
58	MP0002734_abnormal_mechanical_nocicepti	1.04890279
59	MP0005645_abnormal_hypothalamus_physiol	1.03421249
60	MP0002752_abnormal_somatic_nervous	1.03228062
61	MP0000026_abnormal_inner_ear	1.01537703
62	MP0001485_abnormal_pinna_reflex	1.00285599
63	MP0004742_abnormal_vestibular_system	0.99298842
64	MP0001502_abnormal_circadian_rhythm	0.98976488
65	MP0002063_abnormal_learning/memory/cond	0.98811076
66	MP0003635_abnormal_synaptic_transmissio	0.98571671
67	MP0003880_abnormal_central_pattern	0.96465081
68	MP0003315_abnormal_perineum_morphology	0.96329882
69	MP0003011_delayed_dark_adaptation	0.95557970
70	MP0000955_abnormal_spinal_cord	0.95216347
71	MP0003942_abnormal_urinary_system	0.91133019
72	MP0004130_abnormal_muscle_cell	0.89677436
73	MP0002928_abnormal_bile_duct	0.88998422
74	MP0002160_abnormal_reproductive_system	0.88679606
75	MP0001286_abnormal_eye_development	0.88309744
76	MP0003937_abnormal_limbs/digits/tail_de	0.86306843
77	MP0002138_abnormal_hepatobiliary_system	0.85161136
78	MP0003119_abnormal_digestive_system	0.85070001
79	MP0001486_abnormal_startle_reflex	0.85001564
80	MP0008872_abnormal_physiological_respon	0.82860772
81	MP0005389_reproductive_system_phenotype	0.82113986
82	MP0009053_abnormal_anal_canal	0.80936885
83	MP0002067_abnormal_sensory_capabilities	0.80498428
84	MP0001986_abnormal_taste_sensitivity	0.80039515
85	MP0002233_abnormal_nose_morphology	0.79545452
86	MP0002095_abnormal_skin_pigmentation	0.79379780
87	MP0004859_abnormal_synaptic_plasticity	0.78682908
88	MP0002882_abnormal_neuron_morphology	0.77637772
89	MP0009046_muscle_twitch	0.75298839
90	MP0001919_abnormal_reproductive_system	0.74929216
91	MP0006072_abnormal_retinal_apoptosis	0.73465780
92	MP0003959_abnormal_lean_body	0.73059868
93	MP0006036_abnormal_mitochondrial_physio	0.72247230
94	MP0001963_abnormal_hearing_physiology	0.71482180
95	MP0002152_abnormal_brain_morphology	0.70715109
96	MP0002210_abnormal_sex_determination	0.70555491
97	MP0002735_abnormal_chemical_nociception	0.69048768
98	MP0002277_abnormal_respiratory_mucosa	0.68891477
99	MP0000230_abnormal_systemic_arterial	0.68282688
100	MP0000538_abnormal_urinary_bladder	0.65754284

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of cells of the erythroid lineage (HP:0012130)	5.52116630
2	Reticulocytopenia (HP:0001896)	5.30591887
3	Acute necrotizing encephalopathy (HP:0006965)	4.45774514
4	Macrocytic anemia (HP:0001972)	4.24917728
5	Abnormal number of erythroid precursors (HP:0012131)	4.11976432
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.97829486
7	Acute encephalopathy (HP:0006846)	3.70144419
8	Pallor (HP:0000980)	3.68658788
9	Mitochondrial inheritance (HP:0001427)	3.64009482
10	Pancreatic fibrosis (HP:0100732)	3.62887995
11	Progressive macrocephaly (HP:0004481)	3.54865264
12	Adrenal hypoplasia (HP:0000835)	3.33993750
13	Molar tooth sign on MRI (HP:0002419)	3.29963908
14	Abnormality of midbrain morphology (HP:0002418)	3.29963908
15	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.18778686
16	Increased CSF lactate (HP:0002490)	3.16383305
17	Septo-optic dysplasia (HP:0100842)	3.15720116
18	Nephronophthisis (HP:0000090)	3.15274860
19	Medial flaring of the eyebrow (HP:0010747)	3.10476101
20	Pancreatic cysts (HP:0001737)	3.09194158
21	Renal Fanconi syndrome (HP:0001994)	3.06666307
22	Stenosis of the external auditory canal (HP:0000402)	3.04194224
23	Increased hepatocellular lipid droplets (HP:0006565)	3.02388759
24	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.95296974
25	3-Methylglutaconic aciduria (HP:0003535)	2.93693871
26	Lipid accumulation in hepatocytes (HP:0006561)	2.89024669
27	Diastasis recti (HP:0001540)	2.87418112
28	True hermaphroditism (HP:0010459)	2.86991428
29	Abnormal hemoglobin (HP:0011902)	2.74325543
30	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.70385904
31	Cerebral edema (HP:0002181)	2.67551288
32	Increased intramyocellular lipid droplets (HP:0012240)	2.67001915
33	Hepatocellular necrosis (HP:0001404)	2.62908979
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.62052599
35	Gait imbalance (HP:0002141)	2.62015680
36	Absent thumb (HP:0009777)	2.61592307
37	Asplenia (HP:0001746)	2.60158413
38	Type 2 muscle fiber atrophy (HP:0003554)	2.54492460
39	Myokymia (HP:0002411)	2.51379826
40	Abnormality of the renal medulla (HP:0100957)	2.50298453
41	Cystic liver disease (HP:0006706)	2.44802245
42	Congenital primary aphakia (HP:0007707)	2.42873862
43	Anencephaly (HP:0002323)	2.39299655
44	Abnormal pancreas size (HP:0012094)	2.39178278
45	Sclerocornea (HP:0000647)	2.38049628
46	Hepatic necrosis (HP:0002605)	2.37478992
47	Bile duct proliferation (HP:0001408)	2.36767254
48	Abnormal biliary tract physiology (HP:0012439)	2.36767254
49	Increased muscle lipid content (HP:0009058)	2.32414609
50	Hyperthyroidism (HP:0000836)	2.31086950
51	Agitation (HP:0000713)	2.30724558
52	Rib fusion (HP:0000902)	2.30252906
53	Anophthalmia (HP:0000528)	2.29261228
54	Colon cancer (HP:0003003)	2.29040563
55	Optic disc pallor (HP:0000543)	2.27105788
56	Depressed nasal ridge (HP:0000457)	2.26347652
57	Nephrogenic diabetes insipidus (HP:0009806)	2.25677096
58	Muscle fiber atrophy (HP:0100295)	2.24967538
59	Polydipsia (HP:0001959)	2.24610198
60	Abnormal drinking behavior (HP:0030082)	2.24610198
61	Exertional dyspnea (HP:0002875)	2.24017097
62	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.21121465
63	Increased serum lactate (HP:0002151)	2.19896964
64	Abnormality of renal resorption (HP:0011038)	2.18863869
65	Growth hormone deficiency (HP:0000824)	2.17591725
66	Hepatoblastoma (HP:0002884)	2.16139540
67	Supernumerary spleens (HP:0009799)	2.14799806
68	Lactic acidosis (HP:0003128)	2.11112868
69	Optic nerve hypoplasia (HP:0000609)	2.08067055
70	Enlarged kidneys (HP:0000105)	2.07533458
71	Abnormality of the labia minora (HP:0012880)	2.06565306
72	Anomalous pulmonary venous return (HP:0010772)	2.06048866
73	Hypoplastic pelvis (HP:0008839)	2.03224846
74	Chronic hepatic failure (HP:0100626)	2.02736731
75	Renal dysplasia (HP:0000110)	2.00964920
76	Deep palmar crease (HP:0006191)	2.00091878
77	Absent septum pellucidum (HP:0001331)	1.99258014
78	Type II lissencephaly (HP:0007260)	1.98340669
79	Pendular nystagmus (HP:0012043)	1.98279687
80	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.97423722
81	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.97423722
82	Abnormality of magnesium homeostasis (HP:0004921)	1.96304644
83	Poor suck (HP:0002033)	1.96172217
84	Maternal diabetes (HP:0009800)	1.95866649
85	Neoplasm of the adrenal cortex (HP:0100641)	1.94852038
86	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.92723443
87	Leukodystrophy (HP:0002415)	1.91763604
88	Hypomagnesemia (HP:0002917)	1.91114568
89	Vaginal atresia (HP:0000148)	1.86449899
90	Hyperphosphaturia (HP:0003109)	1.83574960
91	Abnormality of urine glucose concentration (HP:0011016)	1.82443902
92	Glycosuria (HP:0003076)	1.82443902
93	Congenital stationary night blindness (HP:0007642)	1.80079438
94	Genital tract atresia (HP:0001827)	1.77936335
95	Exercise intolerance (HP:0003546)	1.76627342
96	Hypoplasia of the radius (HP:0002984)	1.75380331
97	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.74345557
98	Respiratory failure (HP:0002878)	1.73094867
99	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.71722771
100	Abnormality of the pulmonary veins (HP:0011718)	1.71299389

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PIK3CA	3.70540513
2	STK16	3.27853472
3	BMPR1B	3.08322691
4	BCKDK	3.04761232
5	DYRK2	2.83676958
6	WNK4	2.80669433
7	ADRBK2	2.57176232
8	TLK1	2.24106788
9	PINK1	2.07428473
10	CDK19	1.95501501
11	NME2	1.94049874
12	NTRK2	1.77478566
13	GRK1	1.74595959
14	CASK	1.73585113
15	PRKCG	1.68125626
16	CAMK1D	1.58734974
17	TIE1	1.58152351
18	TNIK	1.55700849
19	LRRK2	1.55546721
20	LIMK1	1.53812771
21	MUSK	1.53253726
22	MAP4K2	1.51925439
23	EPHB2	1.47932768
24	NEK1	1.45566374
25	CAMK1G	1.45103835
26	ZAK	1.43406340
27	DYRK1B	1.39567817
28	TAOK3	1.35883961
29	CAMKK2	1.25330018
30	NTRK3	1.25241012
31	BRAF	1.19423111
32	CAMK1	1.14638521
33	ABL2	1.14346306
34	MAP3K11	1.12487115
35	PASK	1.10718011
36	SGK223	1.02778522
37	SGK494	1.02778522
38	FRK	1.02258941
39	MAP2K7	1.00139306
40	PDK2	0.99990810
41	CSNK1G2	0.99736206
42	IRAK2	0.95798141
43	STK11	0.95711156
44	GRK7	0.95460939
45	PHKG2	0.94287268
46	PHKG1	0.94287268
47	PIM2	0.93790122
48	CAMKK1	0.92297184
49	VRK2	0.92174733
50	DAPK3	0.91048418
51	TGFBR1	0.90226789
52	PRKCH	0.88807231
53	MARK1	0.88113644
54	EPHA4	0.87801198
55	MAP3K4	0.86838002
56	WNK3	0.86140304
57	PAK3	0.84014943
58	CSNK1G3	0.83690878
59	STK39	0.80647730
60	MAPK13	0.79999873
61	PRKCQ	0.79679357
62	ADRBK1	0.77480285
63	MINK1	0.76435579
64	RPS6KA6	0.76097187
65	NUAK1	0.75250859
66	CDC7	0.73464232
67	CSNK1G1	0.70880795
68	CSNK2A2	0.70717856
69	TAF1	0.69472735
70	DYRK3	0.67537057
71	INSRR	0.65059165
72	PRKACA	0.63579122
73	RPS6KC1	0.62281730
74	RPS6KL1	0.62281730
75	TYRO3	0.59889270
76	PLK4	0.59019465
77	PRKCI	0.56758127
78	PLK1	0.53361680
79	DAPK2	0.51794916
80	PLK2	0.51242045
81	CSNK1A1L	0.50915525
82	CHEK2	0.50456375
83	RPS6KA2	0.50106358
84	AURKA	0.50023208
85	SGK3	0.49170319
86	CSNK2A1	0.47938213
87	AURKB	0.47765576
88	VRK1	0.47336339
89	PRKCD	0.46563934
90	RPS6KA1	0.44356028
91	PRKCZ	0.44278845
92	DYRK1A	0.43485905
93	AKT3	0.43396684
94	SGK1	0.42344552
95	CSNK1E	0.42082032
96	NEK2	0.41950419
97	MAP3K12	0.41621591
98	MAP2K2	0.41565135
99	OBSCN	0.40692914
100	CDK8	0.40354254

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.47906551
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.82890300
3	Parkinsons disease_Homo sapiens_hsa05012	4.08538758
4	Cardiac muscle contraction_Homo sapiens_hsa04260	3.17949743
5	Huntingtons disease_Homo sapiens_hsa05016	3.02574203
6	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.86303418
7	Alzheimers disease_Homo sapiens_hsa05010	2.77178399
8	RNA polymerase_Homo sapiens_hsa03020	2.40203226
9	Protein export_Homo sapiens_hsa03060	2.29732141
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.07446732
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.77686780
12	Nicotine addiction_Homo sapiens_hsa05033	1.65896389
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.57199892
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.56043673
15	One carbon pool by folate_Homo sapiens_hsa00670	1.55224508
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.43525092
17	Proteasome_Homo sapiens_hsa03050	1.42823035
18	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.35096310
19	Sulfur relay system_Homo sapiens_hsa04122	1.33468093
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.33061223
21	Basal transcription factors_Homo sapiens_hsa03022	1.26762427
22	Folate biosynthesis_Homo sapiens_hsa00790	1.20377235
23	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.19060489
24	RNA degradation_Homo sapiens_hsa03018	1.15678863
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.08450400
26	Basal cell carcinoma_Homo sapiens_hsa05217	1.08268554
27	Phototransduction_Homo sapiens_hsa04744	1.02362994
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.02284515
29	Base excision repair_Homo sapiens_hsa03410	1.00086685
30	Collecting duct acid secretion_Homo sapiens_hsa04966	0.95846128
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.93949164
32	Homologous recombination_Homo sapiens_hsa03440	0.92031825
33	Fanconi anemia pathway_Homo sapiens_hsa03460	0.90970017
34	Peroxisome_Homo sapiens_hsa04146	0.90809274
35	Morphine addiction_Homo sapiens_hsa05032	0.90031517
36	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.88725369
37	Asthma_Homo sapiens_hsa05310	0.87889598
38	Nucleotide excision repair_Homo sapiens_hsa03420	0.84628429
39	Ether lipid metabolism_Homo sapiens_hsa00565	0.83650551
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.81313621
41	Steroid biosynthesis_Homo sapiens_hsa00100	0.80722765
42	Pyruvate metabolism_Homo sapiens_hsa00620	0.80531719
43	Fat digestion and absorption_Homo sapiens_hsa04975	0.79484767
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.78152552
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77826470
46	Tryptophan metabolism_Homo sapiens_hsa00380	0.76913354
47	Butanoate metabolism_Homo sapiens_hsa00650	0.76623851
48	Metabolic pathways_Homo sapiens_hsa01100	0.75618785
49	Purine metabolism_Homo sapiens_hsa00230	0.74512512
50	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.73011725
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.70111217
52	Olfactory transduction_Homo sapiens_hsa04740	0.69006616
53	Nitrogen metabolism_Homo sapiens_hsa00910	0.66650882
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66587074
55	Insulin secretion_Homo sapiens_hsa04911	0.65223447
56	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.60842401
57	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.60676449
58	Taste transduction_Homo sapiens_hsa04742	0.59353107
59	Propanoate metabolism_Homo sapiens_hsa00640	0.58982260
60	Spliceosome_Homo sapiens_hsa03040	0.58330338
61	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.57072257
62	Fatty acid degradation_Homo sapiens_hsa00071	0.55054630
63	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.52423595
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.51989072
65	Notch signaling pathway_Homo sapiens_hsa04330	0.51242490
66	GABAergic synapse_Homo sapiens_hsa04727	0.51191604
67	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.51063711
68	Serotonergic synapse_Homo sapiens_hsa04726	0.49844131
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.48843685
70	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.47796515
71	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.47759004
72	Regulation of autophagy_Homo sapiens_hsa04140	0.42099798
73	RNA transport_Homo sapiens_hsa03013	0.41858432
74	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.41804859
75	Caffeine metabolism_Homo sapiens_hsa00232	0.41384156
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.38617966
77	DNA replication_Homo sapiens_hsa03030	0.38436567
78	Retinol metabolism_Homo sapiens_hsa00830	0.37934105
79	Mismatch repair_Homo sapiens_hsa03430	0.35600339
80	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.35458831
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.34876861
82	Glutamatergic synapse_Homo sapiens_hsa04724	0.33870865
83	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.33628033
84	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.29828526
85	Dopaminergic synapse_Homo sapiens_hsa04728	0.29718760
86	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.29504745
87	Axon guidance_Homo sapiens_hsa04360	0.28954921
88	Circadian entrainment_Homo sapiens_hsa04713	0.28390987
89	Type I diabetes mellitus_Homo sapiens_hsa04940	0.27330949
90	Graft-versus-host disease_Homo sapiens_hsa05332	0.24371486
91	Hippo signaling pathway_Homo sapiens_hsa04390	0.23071906
92	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.23025378
93	Cholinergic synapse_Homo sapiens_hsa04725	0.21790609
94	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.21547912
95	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.21314198
96	Mineral absorption_Homo sapiens_hsa04978	0.21177552
97	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.19095792
98	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.18301624
99	Selenocompound metabolism_Homo sapiens_hsa00450	0.17153710
100	Allograft rejection_Homo sapiens_hsa05330	0.17102348

RPS20P24

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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