

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of gamma-delta T cell activation (GO:0046645) | 6.45448120 |
| 2 | regulation of B cell receptor signaling pathway (GO:0050855) | 5.82608815 |
| 3 | detection of molecule of bacterial origin (GO:0032490) | 5.80172046 |
| 4 | microglial cell activation (GO:0001774) | 5.73513075 |
| 5 | negative regulation of cell killing (GO:0031342) | 5.44957588 |
| 6 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 5.44957588 |
| 7 | positive regulation by symbiont of host defense response (GO:0052509) | 5.27863243 |
| 8 | modulation by symbiont of host defense response (GO:0052031) | 5.27863243 |
| 9 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 5.27863243 |
| 10 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 5.27863243 |
| 11 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 5.27863243 |
| 12 | modulation by symbiont of host immune response (GO:0052553) | 5.27863243 |
| 13 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 5.05094509 |
| 14 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 4.93033397 |
| 15 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 4.86414285 |
| 16 | positive T cell selection (GO:0043368) | 4.80959809 |
| 17 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 4.79606732 |
| 18 | positive thymic T cell selection (GO:0045059) | 4.78613267 |
| 19 | hepatocyte apoptotic process (GO:0097284) | 4.75650283 |
| 20 | regulation of gamma-delta T cell differentiation (GO:0045586) | 4.72010425 |
| 21 | regulation of gamma-delta T cell activation (GO:0046643) | 4.63267607 |
| 22 | macrophage activation involved in immune response (GO:0002281) | 4.57775723 |
| 23 | cellular extravasation (GO:0045123) | 4.48293873 |
| 24 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.46975841 |
| 25 | regulation of necroptotic process (GO:0060544) | 4.45455255 |
| 26 | macrophage activation (GO:0042116) | 4.42960962 |
| 27 | neutrophil mediated immunity (GO:0002446) | 4.33178278 |
| 28 | negative regulation of B cell mediated immunity (GO:0002713) | 4.29802289 |
| 29 | negative regulation of immunoglobulin mediated immune response (GO:0002890) | 4.29802289 |
| 30 | positive regulation of tumor necrosis factor biosynthetic process (GO:0042535) | 4.28093165 |
| 31 | negative regulation of T cell mediated immunity (GO:0002710) | 4.18648917 |
| 32 | myeloid leukocyte mediated immunity (GO:0002444) | 4.12637645 |
| 33 | negative regulation of B cell proliferation (GO:0030889) | 4.09474309 |
| 34 | activated T cell proliferation (GO:0050798) | 4.07469409 |
| 35 | negative T cell selection (GO:0043383) | 4.06344145 |
| 36 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 4.03609345 |
| 37 | phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092) | 4.00461525 |
| 38 | histone H3-K36 demethylation (GO:0070544) | 3.99016835 |
| 39 | negative thymic T cell selection (GO:0045060) | 3.93663205 |
| 40 | detection of external biotic stimulus (GO:0098581) | 3.86174784 |
| 41 | histone mRNA catabolic process (GO:0071044) | 3.80180200 |
| 42 | B cell receptor signaling pathway (GO:0050853) | 3.73682082 |
| 43 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 3.70321938 |
| 44 | regulation of beta-amyloid formation (GO:1902003) | 3.69572611 |
| 45 | negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642) | 3.68009894 |
| 46 | negative regulation of interleukin-12 production (GO:0032695) | 3.67486430 |
| 47 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.65267571 |
| 48 | response to host immune response (GO:0052572) | 3.65267571 |
| 49 | protein K11-linked deubiquitination (GO:0035871) | 3.60213978 |
| 50 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.58701784 |
| 51 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.50827784 |
| 52 | dosage compensation (GO:0007549) | 3.45263102 |
| 53 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.43449732 |
| 54 | response to host (GO:0075136) | 3.43449732 |
| 55 | response to host defenses (GO:0052200) | 3.43449732 |
| 56 | regulation of nitric-oxide synthase biosynthetic process (GO:0051769) | 3.43369674 |
| 57 | positive regulation of receptor recycling (GO:0001921) | 3.39120093 |
| 58 | negative regulation of adaptive immune response (GO:0002820) | 3.39052738 |
| 59 | mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686) | 3.35021628 |
| 60 | positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110 | 3.35021628 |
| 61 | detection of biotic stimulus (GO:0009595) | 3.34583077 |
| 62 | positive regulation of granulocyte differentiation (GO:0030854) | 3.30151857 |
| 63 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.29266833 |
| 64 | regulation of necrotic cell death (GO:0010939) | 3.29045096 |
| 65 | positive regulation of response to oxidative stress (GO:1902884) | 3.25749953 |
| 66 | positive regulation of cellular response to oxidative stress (GO:1900409) | 3.25749953 |
| 67 | negative regulation of complement activation (GO:0045916) | 3.21183179 |
| 68 | detection of other organism (GO:0098543) | 3.17339203 |
| 69 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 3.17019290 |
| 70 | myeloid cell activation involved in immune response (GO:0002275) | 3.15852015 |
| 71 | regulation of regulatory T cell differentiation (GO:0045589) | 3.15222031 |
| 72 | T cell selection (GO:0045058) | 3.14773664 |
| 73 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.14529979 |
| 74 | positive regulation of insulin receptor signaling pathway (GO:0046628) | 3.13854772 |
| 75 | negative regulation of necroptotic process (GO:0060546) | 3.13249297 |
| 76 | regulation of B cell differentiation (GO:0045577) | 3.13149327 |
| 77 | I-kappaB phosphorylation (GO:0007252) | 3.11590967 |
| 78 | leukocyte aggregation (GO:0070486) | 3.08100930 |
| 79 | response to interleukin-15 (GO:0070672) | 3.05359075 |
| 80 | regulation of amyloid precursor protein catabolic process (GO:1902991) | 3.04539950 |
| 81 | protein targeting to vacuole (GO:0006623) | 3.02240502 |
| 82 | protein targeting to lysosome (GO:0006622) | 3.02240502 |
| 83 | establishment of protein localization to vacuole (GO:0072666) | 3.02240502 |
| 84 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.01640909 |
| 85 | histone H3-K4 trimethylation (GO:0080182) | 2.95779350 |
| 86 | interferon-gamma production (GO:0032609) | 2.95765815 |
| 87 | positive regulation of mitochondrial membrane permeability (GO:0035794) | 2.94222476 |
| 88 | neutrophil activation involved in immune response (GO:0002283) | 2.92222267 |
| 89 | negative regulation of inclusion body assembly (GO:0090084) | 2.91897699 |
| 90 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 2.91666842 |
| 91 | respiratory burst (GO:0045730) | 2.90672193 |
| 92 | regulation of isotype switching to IgG isotypes (GO:0048302) | 2.90648172 |
| 93 | negative regulation of myotube differentiation (GO:0010832) | 2.90460024 |
| 94 | regulation of cellular amide metabolic process (GO:0034248) | 2.90120909 |
| 95 | thymic T cell selection (GO:0045061) | 2.89042492 |
| 96 | regulation of MHC class I biosynthetic process (GO:0045343) | 2.88300133 |
| 97 | T cell migration (GO:0072678) | 2.87907633 |
| 98 | negative regulation of humoral immune response (GO:0002921) | 2.86962150 |
| 99 | T cell proliferation (GO:0042098) | 2.84124659 |
| 100 | positive regulation of B cell differentiation (GO:0045579) | 2.83712705 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 5.44617109 |
| 2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 4.99030959 |
| 3 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 4.54166743 |
| 4 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 3.77350697 |
| 5 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 3.54564316 |
| 6 | RUNX_20019798_ChIP-Seq_JUKART_Human | 3.45385740 |
| 7 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.19714728 |
| 8 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.16531401 |
| 9 | SCL_19346495_ChIP-Seq_HPC-7_Human | 3.12494267 |
| 10 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.85900663 |
| 11 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.85865095 |
| 12 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.77077168 |
| 13 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.75141413 |
| 14 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.74412844 |
| 15 | MYB_26560356_Chip-Seq_TH2_Human | 2.53803909 |
| 16 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.45678189 |
| 17 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.37231954 |
| 18 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 2.31708451 |
| 19 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.30035770 |
| 20 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.24399173 |
| 21 | SPI1_23127762_ChIP-Seq_K562_Human | 2.12551598 |
| 22 | MYB_26560356_Chip-Seq_TH1_Human | 2.07302726 |
| 23 | VDR_24787735_ChIP-Seq_THP-1_Human | 2.05670247 |
| 24 | GATA1_22025678_ChIP-Seq_K562_Human | 2.05516264 |
| 25 | SPI1_23547873_ChIP-Seq_NB4_Human | 2.03708507 |
| 26 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.97123841 |
| 27 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.94981061 |
| 28 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.92327967 |
| 29 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.71732260 |
| 30 | TP53_16413492_ChIP-PET_HCT116_Human | 1.71159139 |
| 31 | GATA1_19941826_ChIP-Seq_K562_Human | 1.65770664 |
| 32 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.64593573 |
| 33 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.64080679 |
| 34 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.62117604 |
| 35 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.61695602 |
| 36 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.61579497 |
| 37 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.56479655 |
| 38 | GATA3_26560356_Chip-Seq_TH2_Human | 1.53788344 |
| 39 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.52186721 |
| 40 | MAF_26560356_Chip-Seq_TH1_Human | 1.47341568 |
| 41 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.46568402 |
| 42 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.46568402 |
| 43 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.46568402 |
| 44 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.45839205 |
| 45 | GATA2_19941826_ChIP-Seq_K562_Human | 1.45396237 |
| 46 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.42650810 |
| 47 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.42530011 |
| 48 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.42423645 |
| 49 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.40494332 |
| 50 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.37572413 |
| 51 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.37249654 |
| 52 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.35146364 |
| 53 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.31882197 |
| 54 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.22392239 |
| 55 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.22137995 |
| 56 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.17200673 |
| 57 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.15406791 |
| 58 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 1.15183009 |
| 59 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.12472800 |
| 60 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.12453742 |
| 61 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.09282269 |
| 62 | UTX_26944678_Chip-Seq_JUKART_Human | 1.08799589 |
| 63 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.07799741 |
| 64 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.07283987 |
| 65 | SMRT_27268052_Chip-Seq_Bcells_Human | 1.07234420 |
| 66 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.05174519 |
| 67 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.03496354 |
| 68 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.03208237 |
| 69 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.02806507 |
| 70 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.01541866 |
| 71 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.00535268 |
| 72 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.98366336 |
| 73 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.98029636 |
| 74 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 0.97776019 |
| 75 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.93930414 |
| 76 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.93318019 |
| 77 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.89685221 |
| 78 | MAF_26560356_Chip-Seq_TH2_Human | 0.87804739 |
| 79 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.87582598 |
| 80 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.87265686 |
| 81 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.86648146 |
| 82 | FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 0.84936065 |
| 83 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.84435722 |
| 84 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.84139149 |
| 85 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.83952981 |
| 86 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.83271015 |
| 87 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.83144012 |
| 88 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.82458862 |
| 89 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.82078966 |
| 90 | GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.81715786 |
| 91 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.81064581 |
| 92 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 0.80883483 |
| 93 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.80070099 |
| 94 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.79720238 |
| 95 | GATA3_26560356_Chip-Seq_TH1_Human | 0.78948904 |
| 96 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.78598197 |
| 97 | MYC_22102868_ChIP-Seq_BL_Human | 0.78397725 |
| 98 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.76859900 |
| 99 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 0.76393353 |
| 100 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 0.75226843 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000569_abnormal_digit_pigmentation | 6.89272222 |
| 2 | MP0008260_abnormal_autophagy | 4.99969712 |
| 3 | MP0003724_increased_susceptibility_to | 3.69792205 |
| 4 | MP0001835_abnormal_antigen_presentation | 3.08301985 |
| 5 | MP0003656_abnormal_erythrocyte_physiolo | 3.00088793 |
| 6 | MP0003763_abnormal_thymus_physiology | 2.91149276 |
| 7 | MP0003303_peritoneal_inflammation | 2.70023057 |
| 8 | MP0003787_abnormal_imprinting | 2.68332370 |
| 9 | MP0004381_abnormal_hair_follicle | 2.63025670 |
| 10 | MP0005174_abnormal_tail_pigmentation | 2.61095113 |
| 11 | MP0005451_abnormal_body_composition | 2.45960888 |
| 12 | MP0004883_abnormal_blood_vessel | 2.44097490 |
| 13 | MP0003172_abnormal_lysosome_physiology | 2.42214093 |
| 14 | MP0000015_abnormal_ear_pigmentation | 2.32982518 |
| 15 | MP0001800_abnormal_humoral_immune | 2.32523172 |
| 16 | MP0003221_abnormal_cardiomyocyte_apopto | 2.24242587 |
| 17 | MP0003828_pulmonary_edema | 2.12448469 |
| 18 | MP0008057_abnormal_DNA_replication | 1.98672061 |
| 19 | MP0002419_abnormal_innate_immunity | 1.95730934 |
| 20 | MP0002332_abnormal_exercise_endurance | 1.93788785 |
| 21 | MP0000685_abnormal_immune_system | 1.92998809 |
| 22 | MP0003436_decreased_susceptibility_to | 1.87209858 |
| 23 | MP0005671_abnormal_response_to | 1.85029346 |
| 24 | MP0002420_abnormal_adaptive_immunity | 1.84220844 |
| 25 | MP0001819_abnormal_immune_cell | 1.81626312 |
| 26 | MP0002452_abnormal_antigen_presenting | 1.80578324 |
| 27 | MP0002723_abnormal_immune_serum | 1.80479596 |
| 28 | MP0002166_altered_tumor_susceptibility | 1.79300180 |
| 29 | MP0003300_gastrointestinal_ulcer | 1.78086338 |
| 30 | MP0005025_abnormal_response_to | 1.76026387 |
| 31 | MP0002398_abnormal_bone_marrow | 1.74723063 |
| 32 | MP0005464_abnormal_platelet_physiology | 1.71660426 |
| 33 | MP0005075_abnormal_melanosome_morpholog | 1.69665386 |
| 34 | MP0000703_abnormal_thymus_morphology | 1.64272408 |
| 35 | MP0004808_abnormal_hematopoietic_stem | 1.64123763 |
| 36 | MP0008877_abnormal_DNA_methylation | 1.60000908 |
| 37 | MP0002132_abnormal_respiratory_system | 1.59269679 |
| 38 | MP0002396_abnormal_hematopoietic_system | 1.57882460 |
| 39 | MP0005000_abnormal_immune_tolerance | 1.57196913 |
| 40 | MP0000716_abnormal_immune_system | 1.56770163 |
| 41 | MP0009785_altered_susceptibility_to | 1.56143171 |
| 42 | MP0002405_respiratory_system_inflammati | 1.55883365 |
| 43 | MP0002722_abnormal_immune_system | 1.52329638 |
| 44 | MP0005310_abnormal_salivary_gland | 1.51531717 |
| 45 | MP0000689_abnormal_spleen_morphology | 1.49619926 |
| 46 | MP0005164_abnormal_response_to | 1.48734007 |
| 47 | MP0004484_altered_response_of | 1.45574479 |
| 48 | MP0005387_immune_system_phenotype | 1.41705354 |
| 49 | MP0001790_abnormal_immune_system | 1.41705354 |
| 50 | MP0003866_abnormal_defecation | 1.37922719 |
| 51 | MP0005408_hypopigmentation | 1.34717058 |
| 52 | MP0000858_altered_metastatic_potential | 1.31126317 |
| 53 | MP0002429_abnormal_blood_cell | 1.23899143 |
| 54 | MP0004947_skin_inflammation | 1.19015929 |
| 55 | MP0003690_abnormal_glial_cell | 1.18693509 |
| 56 | MP0000371_diluted_coat_color | 1.18596988 |
| 57 | MP0010307_abnormal_tumor_latency | 1.17969814 |
| 58 | MP0004130_abnormal_muscle_cell | 1.17531294 |
| 59 | MP0005083_abnormal_biliary_tract | 1.14091482 |
| 60 | MP0001845_abnormal_inflammatory_respons | 1.13850394 |
| 61 | MP0001851_eye_inflammation | 1.13433059 |
| 62 | MP0003121_genomic_imprinting | 1.12574454 |
| 63 | MP0003091_abnormal_cell_migration | 1.09660183 |
| 64 | MP0003329_amyloid_beta_deposits | 1.04227538 |
| 65 | MP0001958_emphysema | 1.03820645 |
| 66 | MP0002006_tumorigenesis | 1.02293814 |
| 67 | MP0006082_CNS_inflammation | 1.01101656 |
| 68 | MP0000604_amyloidosis | 1.00248840 |
| 69 | MP0002148_abnormal_hypersensitivity_rea | 0.96903522 |
| 70 | MP0009765_abnormal_xenobiotic_induced | 0.94743859 |
| 71 | MP0000465_gastrointestinal_hemorrhage | 0.91480906 |
| 72 | MP0005376_homeostasis/metabolism_phenot | 0.89021861 |
| 73 | MP0005266_abnormal_metabolism | 0.87710511 |
| 74 | MP0005409_darkened_coat_color | 0.87269008 |
| 75 | MP0009764_decreased_sensitivity_to | 0.83235527 |
| 76 | MP0009763_increased_sensitivity_to | 0.82434827 |
| 77 | MP0003191_abnormal_cellular_cholesterol | 0.81596368 |
| 78 | MP0003186_abnormal_redox_activity | 0.78503342 |
| 79 | MP0002877_abnormal_melanocyte_morpholog | 0.78281203 |
| 80 | MP0001545_abnormal_hematopoietic_system | 0.75933198 |
| 81 | MP0005397_hematopoietic_system_phenotyp | 0.75933198 |
| 82 | MP0002277_abnormal_respiratory_mucosa | 0.75500069 |
| 83 | MP0000427_abnormal_hair_cycle | 0.74831564 |
| 84 | MP0005621_abnormal_cell_physiology | 0.74549962 |
| 85 | MP0008995_early_reproductive_senescence | 0.74346559 |
| 86 | MP0001533_abnormal_skeleton_physiology | 0.73855373 |
| 87 | MP0010155_abnormal_intestine_physiology | 0.72980570 |
| 88 | MP0003941_abnormal_skin_development | 0.71656202 |
| 89 | MP0008469_abnormal_protein_level | 0.70575292 |
| 90 | MP0001663_abnormal_digestive_system | 0.70433002 |
| 91 | MP0001915_intracranial_hemorrhage | 0.70247964 |
| 92 | MP0002928_abnormal_bile_duct | 0.69819240 |
| 93 | MP0003632_abnormal_nervous_system | 0.69498456 |
| 94 | MP0005076_abnormal_cell_differentiation | 0.69434881 |
| 95 | MP0004858_abnormal_nervous_system | 0.68023964 |
| 96 | MP0001853_heart_inflammation | 0.66866390 |
| 97 | MP0002019_abnormal_tumor_incidence | 0.66772532 |
| 98 | MP0009333_abnormal_splenocyte_physiolog | 0.64151661 |
| 99 | MP0002998_abnormal_bone_remodeling | 0.62943212 |
| 100 | MP0002095_abnormal_skin_pigmentation | 0.62834944 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 7.90284152 |
| 2 | Recurrent bacterial skin infections (HP:0005406) | 6.16935253 |
| 3 | T lymphocytopenia (HP:0005403) | 6.12494322 |
| 4 | Abnormality of T cell number (HP:0011839) | 5.61822211 |
| 5 | Recurrent abscess formation (HP:0002722) | 5.19055740 |
| 6 | Gastrointestinal infarctions (HP:0005244) | 4.83055834 |
| 7 | Eczematoid dermatitis (HP:0000976) | 4.56684335 |
| 8 | Retrobulbar optic neuritis (HP:0100654) | 4.39002840 |
| 9 | Optic neuritis (HP:0100653) | 4.39002840 |
| 10 | Recurrent fungal infections (HP:0002841) | 4.29326310 |
| 11 | Myositis (HP:0100614) | 4.18371611 |
| 12 | Orchitis (HP:0100796) | 4.12036362 |
| 13 | Subacute progressive viral hepatitis (HP:0006572) | 3.97716504 |
| 14 | Gingival bleeding (HP:0000225) | 3.94957304 |
| 15 | Gingivitis (HP:0000230) | 3.91299490 |
| 16 | Recurrent skin infections (HP:0001581) | 3.85632986 |
| 17 | Peritonitis (HP:0002586) | 3.85023741 |
| 18 | Postural instability (HP:0002172) | 3.78531907 |
| 19 | Slow saccadic eye movements (HP:0000514) | 3.76884283 |
| 20 | Abnormality of T cells (HP:0002843) | 3.49762039 |
| 21 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.35221915 |
| 22 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.30060730 |
| 23 | Recurrent cutaneous fungal infections (HP:0011370) | 3.30060730 |
| 24 | Spontaneous hematomas (HP:0007420) | 3.29502899 |
| 25 | Periodontitis (HP:0000704) | 3.27480355 |
| 26 | Keratoconjunctivitis sicca (HP:0001097) | 3.22634655 |
| 27 | Resting tremor (HP:0002322) | 3.20161082 |
| 28 | Arterial thrombosis (HP:0004420) | 3.15906685 |
| 29 | Leukocytosis (HP:0001974) | 3.06511475 |
| 30 | Stomatitis (HP:0010280) | 3.04862804 |
| 31 | Recurrent viral infections (HP:0004429) | 3.03158488 |
| 32 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.00139700 |
| 33 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.96137000 |
| 34 | Keratoconjunctivitis (HP:0001096) | 2.95250474 |
| 35 | Encephalitis (HP:0002383) | 2.94007757 |
| 36 | Viral hepatitis (HP:0006562) | 2.90292524 |
| 37 | Papillary thyroid carcinoma (HP:0002895) | 2.87950311 |
| 38 | Conjunctival telangiectasia (HP:0000524) | 2.78377037 |
| 39 | Eosinophilia (HP:0001880) | 2.77617385 |
| 40 | Mediastinal lymphadenopathy (HP:0100721) | 2.73541613 |
| 41 | Epistaxis (HP:0000421) | 2.71839488 |
| 42 | Autoimmune hemolytic anemia (HP:0001890) | 2.64825222 |
| 43 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.63707497 |
| 44 | Abnormality of the fingertips (HP:0001211) | 2.60943850 |
| 45 | Chest pain (HP:0100749) | 2.60526140 |
| 46 | Genetic anticipation (HP:0003743) | 2.59489682 |
| 47 | Recurrent bronchitis (HP:0002837) | 2.57658803 |
| 48 | Granulocytopenia (HP:0001913) | 2.54110978 |
| 49 | Prolonged bleeding time (HP:0003010) | 2.52465827 |
| 50 | Urticaria (HP:0001025) | 2.48996683 |
| 51 | Vasculitis (HP:0002633) | 2.48974534 |
| 52 | Poikilocytosis (HP:0004447) | 2.48624219 |
| 53 | Meningitis (HP:0001287) | 2.47073660 |
| 54 | Hemoptysis (HP:0002105) | 2.45221070 |
| 55 | Abnormality of macrophages (HP:0004311) | 2.41924308 |
| 56 | Hypoplasia of the thymus (HP:0000778) | 2.41191925 |
| 57 | Anorexia (HP:0002039) | 2.39285698 |
| 58 | Abnormality of eosinophils (HP:0001879) | 2.37742023 |
| 59 | Visual hallucinations (HP:0002367) | 2.31923497 |
| 60 | Abnormality of the peritoneum (HP:0002585) | 2.29046368 |
| 61 | Pustule (HP:0200039) | 2.27040319 |
| 62 | Difficulty running (HP:0009046) | 2.26711269 |
| 63 | Microcytic anemia (HP:0001935) | 2.21098474 |
| 64 | Pelvic girdle muscle weakness (HP:0003749) | 2.18832822 |
| 65 | Chronic obstructive pulmonary disease (HP:0006510) | 2.17269079 |
| 66 | Obstructive lung disease (HP:0006536) | 2.17269079 |
| 67 | Dislocated radial head (HP:0003083) | 2.12500257 |
| 68 | Orthostatic hypotension (HP:0001278) | 2.11964450 |
| 69 | Thyroiditis (HP:0100646) | 2.11952675 |
| 70 | Aplasia/Hypoplasia of the macula (HP:0008059) | 2.11114534 |
| 71 | Acute hepatic failure (HP:0006554) | 2.09577092 |
| 72 | Cellulitis (HP:0100658) | 2.08100869 |
| 73 | Glucose intolerance (HP:0000833) | 2.06079573 |
| 74 | Abnormality of the columella (HP:0009929) | 2.03891469 |
| 75 | IgA deficiency (HP:0002720) | 2.02336773 |
| 76 | Myocardial infarction (HP:0001658) | 2.02190380 |
| 77 | Hypochromic microcytic anemia (HP:0004840) | 2.01873262 |
| 78 | Neurodegeneration (HP:0002180) | 1.99893762 |
| 79 | Inflammation of the large intestine (HP:0002037) | 1.97785396 |
| 80 | Hemiplegia (HP:0002301) | 1.97267176 |
| 81 | Pulmonary embolism (HP:0002204) | 1.96199071 |
| 82 | Cheilitis (HP:0100825) | 1.95628800 |
| 83 | Osteolytic defects of the hand bones (HP:0009699) | 1.93624240 |
| 84 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.93624240 |
| 85 | Abnormality of the radial head (HP:0003995) | 1.93432797 |
| 86 | Hypochromic anemia (HP:0001931) | 1.92957166 |
| 87 | Pulmonary infiltrates (HP:0002113) | 1.92168385 |
| 88 | Aplasia/Hypoplasia affecting the retina (HP:0008061) | 1.91143226 |
| 89 | Pulmonary artery stenosis (HP:0004415) | 1.90603024 |
| 90 | Abnormality of the endocardium (HP:0004306) | 1.90218697 |
| 91 | Colitis (HP:0002583) | 1.89321230 |
| 92 | Low anterior hairline (HP:0000294) | 1.89084181 |
| 93 | IgM deficiency (HP:0002850) | 1.88930150 |
| 94 | Gangrene (HP:0100758) | 1.85724997 |
| 95 | Micronodular cirrhosis (HP:0001413) | 1.85389233 |
| 96 | Absent frontal sinuses (HP:0002688) | 1.82015880 |
| 97 | Neoplasm of the tracheobronchial system (HP:0100552) | 1.80469081 |
| 98 | Acute myeloid leukemia (HP:0004808) | 1.80250986 |
| 99 | Thyroid carcinoma (HP:0002890) | 1.78681081 |
| 100 | Ocular albinism (HP:0001107) | 1.77407378 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RIPK4 | 4.82948152 |
| 2 | BLK | 3.39276591 |
| 3 | MAP2K3 | 2.65626434 |
| 4 | GRK6 | 2.44324625 |
| 5 | CSK | 2.41246896 |
| 6 | IKBKE | 2.41111134 |
| 7 | PTK2B | 2.36074662 |
| 8 | WNK1 | 2.33917940 |
| 9 | STK4 | 2.33619437 |
| 10 | FRK | 2.21085022 |
| 11 | FGR | 2.19885251 |
| 12 | PIK3CG | 2.11710622 |
| 13 | TXK | 2.07330076 |
| 14 | SGK2 | 2.06447238 |
| 15 | IRAK4 | 1.97815677 |
| 16 | JAK3 | 1.90374972 |
| 17 | TAOK3 | 1.83391565 |
| 18 | MAP3K2 | 1.83372281 |
| 19 | IRAK2 | 1.71963468 |
| 20 | FES | 1.70966155 |
| 21 | MAP4K1 | 1.68587066 |
| 22 | SYK | 1.65459076 |
| 23 | BMPR2 | 1.63832880 |
| 24 | TYK2 | 1.61318873 |
| 25 | MARK3 | 1.59457216 |
| 26 | MARK2 | 1.59231531 |
| 27 | SGK3 | 1.53501463 |
| 28 | YES1 | 1.50770313 |
| 29 | IRAK1 | 1.48413249 |
| 30 | FGFR3 | 1.43967770 |
| 31 | GRK5 | 1.41154137 |
| 32 | BTK | 1.40673524 |
| 33 | LRRK2 | 1.36737929 |
| 34 | JAK1 | 1.35574616 |
| 35 | TAOK1 | 1.26141600 |
| 36 | ERBB2 | 1.24980617 |
| 37 | PIM1 | 1.24437315 |
| 38 | MAP3K14 | 1.19172416 |
| 39 | ZAP70 | 1.19031017 |
| 40 | HCK | 1.15620315 |
| 41 | SGK494 | 1.12952715 |
| 42 | SGK223 | 1.12952715 |
| 43 | TEC | 1.11669880 |
| 44 | MAP3K1 | 1.11065340 |
| 45 | TRPM7 | 1.09600727 |
| 46 | MAP3K3 | 1.09138681 |
| 47 | PLK2 | 1.01308917 |
| 48 | MAP3K6 | 0.99044717 |
| 49 | NLK | 0.98897488 |
| 50 | ITK | 0.98072817 |
| 51 | LYN | 0.97162724 |
| 52 | DMPK | 0.92723946 |
| 53 | LCK | 0.92130642 |
| 54 | JAK2 | 0.90302420 |
| 55 | EPHB1 | 0.89520067 |
| 56 | CAMK1G | 0.87167846 |
| 57 | STK16 | 0.85766545 |
| 58 | AKT3 | 0.84701487 |
| 59 | STK11 | 0.82556418 |
| 60 | MATK | 0.82014433 |
| 61 | NEK6 | 0.78604202 |
| 62 | TAOK2 | 0.75915349 |
| 63 | MAP3K7 | 0.75222011 |
| 64 | SGK1 | 0.74310293 |
| 65 | CDK12 | 0.71738135 |
| 66 | STK10 | 0.71694559 |
| 67 | MAP3K5 | 0.71485473 |
| 68 | CAMKK2 | 0.71467081 |
| 69 | PAK3 | 0.70589910 |
| 70 | STK38 | 0.69020639 |
| 71 | RAF1 | 0.68210416 |
| 72 | DYRK1A | 0.67868910 |
| 73 | ACVR1B | 0.65425298 |
| 74 | KSR1 | 0.61564760 |
| 75 | MAP3K13 | 0.60256701 |
| 76 | TGFBR2 | 0.59309983 |
| 77 | IKBKB | 0.56738847 |
| 78 | MELK | 0.55445205 |
| 79 | EGFR | 0.55012856 |
| 80 | KSR2 | 0.54583296 |
| 81 | PDGFRB | 0.53097765 |
| 82 | PDK1 | 0.51771479 |
| 83 | FGFR4 | 0.48219390 |
| 84 | CAMK1D | 0.45695334 |
| 85 | RPS6KA5 | 0.43588151 |
| 86 | BRD4 | 0.42938870 |
| 87 | RPS6KA4 | 0.42055420 |
| 88 | PRKAA2 | 0.41869336 |
| 89 | SIK3 | 0.41112804 |
| 90 | PTK6 | 0.40574196 |
| 91 | SIK2 | 0.40532310 |
| 92 | CAMK4 | 0.40286871 |
| 93 | ADRBK1 | 0.40142306 |
| 94 | HIPK2 | 0.38653505 |
| 95 | FYN | 0.38618811 |
| 96 | CHUK | 0.38400224 |
| 97 | PRPF4B | 0.37888385 |
| 98 | CDC42BPA | 0.36594643 |
| 99 | KIT | 0.36359733 |
| 100 | MAP3K11 | 0.35701661 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Leishmaniasis_Homo sapiens_hsa05140 | 2.96852356 |
| 2 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.68335954 |
| 3 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.48168074 |
| 4 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 2.39405017 |
| 5 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.31762772 |
| 6 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.28645349 |
| 7 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.25276459 |
| 8 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 2.12021174 |
| 9 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 2.04509579 |
| 10 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.98501612 |
| 11 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.97808149 |
| 12 | Measles_Homo sapiens_hsa05162 | 1.87910890 |
| 13 | Tuberculosis_Homo sapiens_hsa05152 | 1.87076015 |
| 14 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.79845081 |
| 15 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.77274797 |
| 16 | Malaria_Homo sapiens_hsa05144 | 1.72276750 |
| 17 | Legionellosis_Homo sapiens_hsa05134 | 1.69438650 |
| 18 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.64401980 |
| 19 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.62548934 |
| 20 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.62132799 |
| 21 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.58735868 |
| 22 | FoxO signaling pathway_Homo sapiens_hsa04068 | 1.51152985 |
| 23 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.49098861 |
| 24 | Hepatitis B_Homo sapiens_hsa05161 | 1.46113061 |
| 25 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.46070123 |
| 26 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.44275179 |
| 27 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.42386969 |
| 28 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 1.41497590 |
| 29 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.40818660 |
| 30 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.38547429 |
| 31 | Influenza A_Homo sapiens_hsa05164 | 1.38465769 |
| 32 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.37169576 |
| 33 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.33903868 |
| 34 | Platelet activation_Homo sapiens_hsa04611 | 1.32396918 |
| 35 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.28374500 |
| 36 | Endometrial cancer_Homo sapiens_hsa05213 | 1.27652677 |
| 37 | Apoptosis_Homo sapiens_hsa04210 | 1.26151176 |
| 38 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.23420121 |
| 39 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 1.18810914 |
| 40 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.17144473 |
| 41 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.16946643 |
| 42 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.16118004 |
| 43 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.15770127 |
| 44 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.15700830 |
| 45 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.11410042 |
| 46 | Hepatitis C_Homo sapiens_hsa05160 | 1.09613226 |
| 47 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.07778257 |
| 48 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.02664164 |
| 49 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 1.01047968 |
| 50 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.94925995 |
| 51 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.93066146 |
| 52 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.92539666 |
| 53 | Glioma_Homo sapiens_hsa05214 | 0.88780077 |
| 54 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.88242890 |
| 55 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.87191198 |
| 56 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.85852640 |
| 57 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.81611910 |
| 58 | Allograft rejection_Homo sapiens_hsa05330 | 0.81385758 |
| 59 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.80068066 |
| 60 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.78184136 |
| 61 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.78082376 |
| 62 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.74733740 |
| 63 | Insulin resistance_Homo sapiens_hsa04931 | 0.74525907 |
| 64 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.74476145 |
| 65 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.74159391 |
| 66 | Prostate cancer_Homo sapiens_hsa05215 | 0.72134046 |
| 67 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.71631748 |
| 68 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.70169259 |
| 69 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.69673599 |
| 70 | Colorectal cancer_Homo sapiens_hsa05210 | 0.65817377 |
| 71 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.65071642 |
| 72 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.64987855 |
| 73 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.64468670 |
| 74 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.63379502 |
| 75 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.62409546 |
| 76 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.62219163 |
| 77 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.61512633 |
| 78 | HTLV-I infection_Homo sapiens_hsa05166 | 0.61012587 |
| 79 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.59780084 |
| 80 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.57771268 |
| 81 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.57722436 |
| 82 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.56884574 |
| 83 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.55629061 |
| 84 | Phagosome_Homo sapiens_hsa04145 | 0.55352294 |
| 85 | Long-term potentiation_Homo sapiens_hsa04720 | 0.55057343 |
| 86 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.54914119 |
| 87 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.54884278 |
| 88 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.54498743 |
| 89 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.52970980 |
| 90 | Thyroid cancer_Homo sapiens_hsa05216 | 0.52310259 |
| 91 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.49637819 |
| 92 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.49268905 |
| 93 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.47950694 |
| 94 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.47805950 |
| 95 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.47289251 |
| 96 | Pertussis_Homo sapiens_hsa05133 | 0.46566622 |
| 97 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.45844524 |
| 98 | Viral myocarditis_Homo sapiens_hsa05416 | 0.44170347 |
| 99 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.43792574 |
| 100 | Amoebiasis_Homo sapiens_hsa05146 | 0.42745576 |

