RPS20P31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.45448120
2regulation of B cell receptor signaling pathway (GO:0050855)5.82608815
3detection of molecule of bacterial origin (GO:0032490)5.80172046
4microglial cell activation (GO:0001774)5.73513075
5negative regulation of cell killing (GO:0031342)5.44957588
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.44957588
7positive regulation by symbiont of host defense response (GO:0052509)5.27863243
8modulation by symbiont of host defense response (GO:0052031)5.27863243
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.27863243
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.27863243
11positive regulation by organism of defense response of other organism involved in symbiotic interact5.27863243
12modulation by symbiont of host immune response (GO:0052553)5.27863243
13regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)5.05094509
14positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.93033397
15negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.86414285
16positive T cell selection (GO:0043368)4.80959809
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.79606732
18positive thymic T cell selection (GO:0045059)4.78613267
19hepatocyte apoptotic process (GO:0097284)4.75650283
20regulation of gamma-delta T cell differentiation (GO:0045586)4.72010425
21regulation of gamma-delta T cell activation (GO:0046643)4.63267607
22macrophage activation involved in immune response (GO:0002281)4.57775723
23cellular extravasation (GO:0045123)4.48293873
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.46975841
25regulation of necroptotic process (GO:0060544)4.45455255
26macrophage activation (GO:0042116)4.42960962
27neutrophil mediated immunity (GO:0002446)4.33178278
28negative regulation of B cell mediated immunity (GO:0002713)4.29802289
29negative regulation of immunoglobulin mediated immune response (GO:0002890)4.29802289
30positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.28093165
31negative regulation of T cell mediated immunity (GO:0002710)4.18648917
32myeloid leukocyte mediated immunity (GO:0002444)4.12637645
33negative regulation of B cell proliferation (GO:0030889)4.09474309
34activated T cell proliferation (GO:0050798)4.07469409
35negative T cell selection (GO:0043383)4.06344145
36negative regulation of lymphocyte mediated immunity (GO:0002707)4.03609345
37phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.00461525
38histone H3-K36 demethylation (GO:0070544)3.99016835
39negative thymic T cell selection (GO:0045060)3.93663205
40detection of external biotic stimulus (GO:0098581)3.86174784
41histone mRNA catabolic process (GO:0071044)3.80180200
42B cell receptor signaling pathway (GO:0050853)3.73682082
43negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.70321938
44regulation of beta-amyloid formation (GO:1902003)3.69572611
45negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.68009894
46negative regulation of interleukin-12 production (GO:0032695)3.67486430
47response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.65267571
48response to host immune response (GO:0052572)3.65267571
49protein K11-linked deubiquitination (GO:0035871)3.60213978
50monoubiquitinated protein deubiquitination (GO:0035520)3.58701784
51regulation of interferon-beta biosynthetic process (GO:0045357)3.50827784
52dosage compensation (GO:0007549)3.45263102
53response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.43449732
54response to host (GO:0075136)3.43449732
55response to host defenses (GO:0052200)3.43449732
56regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.43369674
57positive regulation of receptor recycling (GO:0001921)3.39120093
58negative regulation of adaptive immune response (GO:0002820)3.39052738
59mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.35021628
60positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.35021628
61detection of biotic stimulus (GO:0009595)3.34583077
62positive regulation of granulocyte differentiation (GO:0030854)3.30151857
63antigen processing and presentation via MHC class Ib (GO:0002475)3.29266833
64regulation of necrotic cell death (GO:0010939)3.29045096
65positive regulation of response to oxidative stress (GO:1902884)3.25749953
66positive regulation of cellular response to oxidative stress (GO:1900409)3.25749953
67negative regulation of complement activation (GO:0045916)3.21183179
68detection of other organism (GO:0098543)3.17339203
69positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.17019290
70myeloid cell activation involved in immune response (GO:0002275)3.15852015
71regulation of regulatory T cell differentiation (GO:0045589)3.15222031
72T cell selection (GO:0045058)3.14773664
73negative regulation of leukocyte mediated immunity (GO:0002704)3.14529979
74positive regulation of insulin receptor signaling pathway (GO:0046628)3.13854772
75negative regulation of necroptotic process (GO:0060546)3.13249297
76regulation of B cell differentiation (GO:0045577)3.13149327
77I-kappaB phosphorylation (GO:0007252)3.11590967
78leukocyte aggregation (GO:0070486)3.08100930
79response to interleukin-15 (GO:0070672)3.05359075
80regulation of amyloid precursor protein catabolic process (GO:1902991)3.04539950
81protein targeting to vacuole (GO:0006623)3.02240502
82protein targeting to lysosome (GO:0006622)3.02240502
83establishment of protein localization to vacuole (GO:0072666)3.02240502
84regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.01640909
85histone H3-K4 trimethylation (GO:0080182)2.95779350
86interferon-gamma production (GO:0032609)2.95765815
87positive regulation of mitochondrial membrane permeability (GO:0035794)2.94222476
88neutrophil activation involved in immune response (GO:0002283)2.92222267
89negative regulation of inclusion body assembly (GO:0090084)2.91897699
90regulation of interleukin-12 biosynthetic process (GO:0045075)2.91666842
91respiratory burst (GO:0045730)2.90672193
92regulation of isotype switching to IgG isotypes (GO:0048302)2.90648172
93negative regulation of myotube differentiation (GO:0010832)2.90460024
94regulation of cellular amide metabolic process (GO:0034248)2.90120909
95thymic T cell selection (GO:0045061)2.89042492
96regulation of MHC class I biosynthetic process (GO:0045343)2.88300133
97T cell migration (GO:0072678)2.87907633
98negative regulation of humoral immune response (GO:0002921)2.86962150
99T cell proliferation (GO:0042098)2.84124659
100positive regulation of B cell differentiation (GO:0045579)2.83712705

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.44617109
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.99030959
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.54166743
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.77350697
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.54564316
6RUNX_20019798_ChIP-Seq_JUKART_Human3.45385740
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.19714728
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.16531401
9SCL_19346495_ChIP-Seq_HPC-7_Human3.12494267
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.85900663
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.85865095
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.77077168
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.75141413
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.74412844
15MYB_26560356_Chip-Seq_TH2_Human2.53803909
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.45678189
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.37231954
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.31708451
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.30035770
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24399173
21SPI1_23127762_ChIP-Seq_K562_Human2.12551598
22MYB_26560356_Chip-Seq_TH1_Human2.07302726
23VDR_24787735_ChIP-Seq_THP-1_Human2.05670247
24GATA1_22025678_ChIP-Seq_K562_Human2.05516264
25SPI1_23547873_ChIP-Seq_NB4_Human2.03708507
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97123841
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.94981061
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.92327967
29GATA3_27048872_Chip-Seq_THYMUS_Human1.71732260
30TP53_16413492_ChIP-PET_HCT116_Human1.71159139
31GATA1_19941826_ChIP-Seq_K562_Human1.65770664
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64593573
33VDR_24763502_ChIP-Seq_THP-1_Human1.64080679
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62117604
35PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.61695602
36PU_27001747_Chip-Seq_BMDM_Mouse1.61579497
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56479655
38GATA3_26560356_Chip-Seq_TH2_Human1.53788344
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52186721
40MAF_26560356_Chip-Seq_TH1_Human1.47341568
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.46568402
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.46568402
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.46568402
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45839205
45GATA2_19941826_ChIP-Seq_K562_Human1.45396237
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.42650810
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.42530011
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42423645
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40494332
50GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37572413
51RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.37249654
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35146364
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.31882197
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.22392239
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22137995
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.17200673
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15406791
58GATA1_19941827_ChIP-Seq_MEL86_Mouse1.15183009
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12472800
60VDR_21846776_ChIP-Seq_THP-1_Human1.12453742
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09282269
62UTX_26944678_Chip-Seq_JUKART_Human1.08799589
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.07799741
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07283987
65SMRT_27268052_Chip-Seq_Bcells_Human1.07234420
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05174519
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03496354
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03208237
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.02806507
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.01541866
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.00535268
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98366336
73GATA2_21666600_ChIP-Seq_HMVEC_Human0.98029636
74RUNX1_22412390_ChIP-Seq_EML_Mouse0.97776019
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93930414
76TCF7_22412390_ChIP-Seq_EML_Mouse0.93318019
77OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89685221
78MAF_26560356_Chip-Seq_TH2_Human0.87804739
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87582598
80POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87265686
81NFE2_27457419_Chip-Seq_LIVER_Mouse0.86648146
82FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84936065
83ER_23166858_ChIP-Seq_MCF-7_Human0.84435722
84TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.84139149
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83952981
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83271015
87SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.83144012
88PRDM14_20953172_ChIP-Seq_ESCs_Human0.82458862
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82078966
90GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.81715786
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81064581
92KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.80883483
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80070099
94SALL4_22934838_ChIP-ChIP_CD34+_Human0.79720238
95GATA3_26560356_Chip-Seq_TH1_Human0.78948904
96RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.78598197
97MYC_22102868_ChIP-Seq_BL_Human0.78397725
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.76859900
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.76393353
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.75226843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.89272222
2MP0008260_abnormal_autophagy4.99969712
3MP0003724_increased_susceptibility_to3.69792205
4MP0001835_abnormal_antigen_presentation3.08301985
5MP0003656_abnormal_erythrocyte_physiolo3.00088793
6MP0003763_abnormal_thymus_physiology2.91149276
7MP0003303_peritoneal_inflammation2.70023057
8MP0003787_abnormal_imprinting2.68332370
9MP0004381_abnormal_hair_follicle2.63025670
10MP0005174_abnormal_tail_pigmentation2.61095113
11MP0005451_abnormal_body_composition2.45960888
12MP0004883_abnormal_blood_vessel2.44097490
13MP0003172_abnormal_lysosome_physiology2.42214093
14MP0000015_abnormal_ear_pigmentation2.32982518
15MP0001800_abnormal_humoral_immune2.32523172
16MP0003221_abnormal_cardiomyocyte_apopto2.24242587
17MP0003828_pulmonary_edema2.12448469
18MP0008057_abnormal_DNA_replication1.98672061
19MP0002419_abnormal_innate_immunity1.95730934
20MP0002332_abnormal_exercise_endurance1.93788785
21MP0000685_abnormal_immune_system1.92998809
22MP0003436_decreased_susceptibility_to1.87209858
23MP0005671_abnormal_response_to1.85029346
24MP0002420_abnormal_adaptive_immunity1.84220844
25MP0001819_abnormal_immune_cell1.81626312
26MP0002452_abnormal_antigen_presenting1.80578324
27MP0002723_abnormal_immune_serum1.80479596
28MP0002166_altered_tumor_susceptibility1.79300180
29MP0003300_gastrointestinal_ulcer1.78086338
30MP0005025_abnormal_response_to1.76026387
31MP0002398_abnormal_bone_marrow1.74723063
32MP0005464_abnormal_platelet_physiology1.71660426
33MP0005075_abnormal_melanosome_morpholog1.69665386
34MP0000703_abnormal_thymus_morphology1.64272408
35MP0004808_abnormal_hematopoietic_stem1.64123763
36MP0008877_abnormal_DNA_methylation1.60000908
37MP0002132_abnormal_respiratory_system1.59269679
38MP0002396_abnormal_hematopoietic_system1.57882460
39MP0005000_abnormal_immune_tolerance1.57196913
40MP0000716_abnormal_immune_system1.56770163
41MP0009785_altered_susceptibility_to1.56143171
42MP0002405_respiratory_system_inflammati1.55883365
43MP0002722_abnormal_immune_system1.52329638
44MP0005310_abnormal_salivary_gland1.51531717
45MP0000689_abnormal_spleen_morphology1.49619926
46MP0005164_abnormal_response_to1.48734007
47MP0004484_altered_response_of1.45574479
48MP0005387_immune_system_phenotype1.41705354
49MP0001790_abnormal_immune_system1.41705354
50MP0003866_abnormal_defecation1.37922719
51MP0005408_hypopigmentation1.34717058
52MP0000858_altered_metastatic_potential1.31126317
53MP0002429_abnormal_blood_cell1.23899143
54MP0004947_skin_inflammation1.19015929
55MP0003690_abnormal_glial_cell1.18693509
56MP0000371_diluted_coat_color1.18596988
57MP0010307_abnormal_tumor_latency1.17969814
58MP0004130_abnormal_muscle_cell1.17531294
59MP0005083_abnormal_biliary_tract1.14091482
60MP0001845_abnormal_inflammatory_respons1.13850394
61MP0001851_eye_inflammation1.13433059
62MP0003121_genomic_imprinting1.12574454
63MP0003091_abnormal_cell_migration1.09660183
64MP0003329_amyloid_beta_deposits1.04227538
65MP0001958_emphysema1.03820645
66MP0002006_tumorigenesis1.02293814
67MP0006082_CNS_inflammation1.01101656
68MP0000604_amyloidosis1.00248840
69MP0002148_abnormal_hypersensitivity_rea0.96903522
70MP0009765_abnormal_xenobiotic_induced0.94743859
71MP0000465_gastrointestinal_hemorrhage0.91480906
72MP0005376_homeostasis/metabolism_phenot0.89021861
73MP0005266_abnormal_metabolism0.87710511
74MP0005409_darkened_coat_color0.87269008
75MP0009764_decreased_sensitivity_to0.83235527
76MP0009763_increased_sensitivity_to0.82434827
77MP0003191_abnormal_cellular_cholesterol0.81596368
78MP0003186_abnormal_redox_activity0.78503342
79MP0002877_abnormal_melanocyte_morpholog0.78281203
80MP0001545_abnormal_hematopoietic_system0.75933198
81MP0005397_hematopoietic_system_phenotyp0.75933198
82MP0002277_abnormal_respiratory_mucosa0.75500069
83MP0000427_abnormal_hair_cycle0.74831564
84MP0005621_abnormal_cell_physiology0.74549962
85MP0008995_early_reproductive_senescence0.74346559
86MP0001533_abnormal_skeleton_physiology0.73855373
87MP0010155_abnormal_intestine_physiology0.72980570
88MP0003941_abnormal_skin_development0.71656202
89MP0008469_abnormal_protein_level0.70575292
90MP0001663_abnormal_digestive_system0.70433002
91MP0001915_intracranial_hemorrhage0.70247964
92MP0002928_abnormal_bile_duct0.69819240
93MP0003632_abnormal_nervous_system0.69498456
94MP0005076_abnormal_cell_differentiation0.69434881
95MP0004858_abnormal_nervous_system0.68023964
96MP0001853_heart_inflammation0.66866390
97MP0002019_abnormal_tumor_incidence0.66772532
98MP0009333_abnormal_splenocyte_physiolog0.64151661
99MP0002998_abnormal_bone_remodeling0.62943212
100MP0002095_abnormal_skin_pigmentation0.62834944

Predicted human phenotypes

RankGene SetZ-score
1Parkinsonism with favorable response to dopaminergic medication (HP:0002548)7.90284152
2Recurrent bacterial skin infections (HP:0005406)6.16935253
3T lymphocytopenia (HP:0005403)6.12494322
4Abnormality of T cell number (HP:0011839)5.61822211
5Recurrent abscess formation (HP:0002722)5.19055740
6Gastrointestinal infarctions (HP:0005244)4.83055834
7Eczematoid dermatitis (HP:0000976)4.56684335
8Retrobulbar optic neuritis (HP:0100654)4.39002840
9Optic neuritis (HP:0100653)4.39002840
10Recurrent fungal infections (HP:0002841)4.29326310
11Myositis (HP:0100614)4.18371611
12Orchitis (HP:0100796)4.12036362
13Subacute progressive viral hepatitis (HP:0006572)3.97716504
14Gingival bleeding (HP:0000225)3.94957304
15Gingivitis (HP:0000230)3.91299490
16Recurrent skin infections (HP:0001581)3.85632986
17Peritonitis (HP:0002586)3.85023741
18Postural instability (HP:0002172)3.78531907
19Slow saccadic eye movements (HP:0000514)3.76884283
20Abnormality of T cells (HP:0002843)3.49762039
21Recurrent gram-negative bacterial infections (HP:0005420)3.35221915
22Chronic mucocutaneous candidiasis (HP:0002728)3.30060730
23Recurrent cutaneous fungal infections (HP:0011370)3.30060730
24Spontaneous hematomas (HP:0007420)3.29502899
25Periodontitis (HP:0000704)3.27480355
26Keratoconjunctivitis sicca (HP:0001097)3.22634655
27Resting tremor (HP:0002322)3.20161082
28Arterial thrombosis (HP:0004420)3.15906685
29Leukocytosis (HP:0001974)3.06511475
30Stomatitis (HP:0010280)3.04862804
31Recurrent viral infections (HP:0004429)3.03158488
32Elevated erythrocyte sedimentation rate (HP:0003565)3.00139700
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.96137000
34Keratoconjunctivitis (HP:0001096)2.95250474
35Encephalitis (HP:0002383)2.94007757
36Viral hepatitis (HP:0006562)2.90292524
37Papillary thyroid carcinoma (HP:0002895)2.87950311
38Conjunctival telangiectasia (HP:0000524)2.78377037
39Eosinophilia (HP:0001880)2.77617385
40Mediastinal lymphadenopathy (HP:0100721)2.73541613
41Epistaxis (HP:0000421)2.71839488
42Autoimmune hemolytic anemia (HP:0001890)2.64825222
43Abnormality of the vasculature of the conjunctiva (HP:0008054)2.63707497
44Abnormality of the fingertips (HP:0001211)2.60943850
45Chest pain (HP:0100749)2.60526140
46Genetic anticipation (HP:0003743)2.59489682
47Recurrent bronchitis (HP:0002837)2.57658803
48Granulocytopenia (HP:0001913)2.54110978
49Prolonged bleeding time (HP:0003010)2.52465827
50Urticaria (HP:0001025)2.48996683
51Vasculitis (HP:0002633)2.48974534
52Poikilocytosis (HP:0004447)2.48624219
53Meningitis (HP:0001287)2.47073660
54Hemoptysis (HP:0002105)2.45221070
55Abnormality of macrophages (HP:0004311)2.41924308
56Hypoplasia of the thymus (HP:0000778)2.41191925
57Anorexia (HP:0002039)2.39285698
58Abnormality of eosinophils (HP:0001879)2.37742023
59Visual hallucinations (HP:0002367)2.31923497
60Abnormality of the peritoneum (HP:0002585)2.29046368
61Pustule (HP:0200039)2.27040319
62Difficulty running (HP:0009046)2.26711269
63Microcytic anemia (HP:0001935)2.21098474
64Pelvic girdle muscle weakness (HP:0003749)2.18832822
65Chronic obstructive pulmonary disease (HP:0006510)2.17269079
66Obstructive lung disease (HP:0006536)2.17269079
67Dislocated radial head (HP:0003083)2.12500257
68Orthostatic hypotension (HP:0001278)2.11964450
69Thyroiditis (HP:0100646)2.11952675
70Aplasia/Hypoplasia of the macula (HP:0008059)2.11114534
71Acute hepatic failure (HP:0006554)2.09577092
72Cellulitis (HP:0100658)2.08100869
73Glucose intolerance (HP:0000833)2.06079573
74Abnormality of the columella (HP:0009929)2.03891469
75IgA deficiency (HP:0002720)2.02336773
76Myocardial infarction (HP:0001658)2.02190380
77Hypochromic microcytic anemia (HP:0004840)2.01873262
78Neurodegeneration (HP:0002180)1.99893762
79Inflammation of the large intestine (HP:0002037)1.97785396
80Hemiplegia (HP:0002301)1.97267176
81Pulmonary embolism (HP:0002204)1.96199071
82Cheilitis (HP:0100825)1.95628800
83Osteolytic defects of the hand bones (HP:0009699)1.93624240
84Osteolytic defects of the phalanges of the hand (HP:0009771)1.93624240
85Abnormality of the radial head (HP:0003995)1.93432797
86Hypochromic anemia (HP:0001931)1.92957166
87Pulmonary infiltrates (HP:0002113)1.92168385
88Aplasia/Hypoplasia affecting the retina (HP:0008061)1.91143226
89Pulmonary artery stenosis (HP:0004415)1.90603024
90Abnormality of the endocardium (HP:0004306)1.90218697
91Colitis (HP:0002583)1.89321230
92Low anterior hairline (HP:0000294)1.89084181
93IgM deficiency (HP:0002850)1.88930150
94Gangrene (HP:0100758)1.85724997
95Micronodular cirrhosis (HP:0001413)1.85389233
96Absent frontal sinuses (HP:0002688)1.82015880
97Neoplasm of the tracheobronchial system (HP:0100552)1.80469081
98Acute myeloid leukemia (HP:0004808)1.80250986
99Thyroid carcinoma (HP:0002890)1.78681081
100Ocular albinism (HP:0001107)1.77407378

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.82948152
2BLK3.39276591
3MAP2K32.65626434
4GRK62.44324625
5CSK2.41246896
6IKBKE2.41111134
7PTK2B2.36074662
8WNK12.33917940
9STK42.33619437
10FRK2.21085022
11FGR2.19885251
12PIK3CG2.11710622
13TXK2.07330076
14SGK22.06447238
15IRAK41.97815677
16JAK31.90374972
17TAOK31.83391565
18MAP3K21.83372281
19IRAK21.71963468
20FES1.70966155
21MAP4K11.68587066
22SYK1.65459076
23BMPR21.63832880
24TYK21.61318873
25MARK31.59457216
26MARK21.59231531
27SGK31.53501463
28YES11.50770313
29IRAK11.48413249
30FGFR31.43967770
31GRK51.41154137
32BTK1.40673524
33LRRK21.36737929
34JAK11.35574616
35TAOK11.26141600
36ERBB21.24980617
37PIM11.24437315
38MAP3K141.19172416
39ZAP701.19031017
40HCK1.15620315
41SGK4941.12952715
42SGK2231.12952715
43TEC1.11669880
44MAP3K11.11065340
45TRPM71.09600727
46MAP3K31.09138681
47PLK21.01308917
48MAP3K60.99044717
49NLK0.98897488
50ITK0.98072817
51LYN0.97162724
52DMPK0.92723946
53LCK0.92130642
54JAK20.90302420
55EPHB10.89520067
56CAMK1G0.87167846
57STK160.85766545
58AKT30.84701487
59STK110.82556418
60MATK0.82014433
61NEK60.78604202
62TAOK20.75915349
63MAP3K70.75222011
64SGK10.74310293
65CDK120.71738135
66STK100.71694559
67MAP3K50.71485473
68CAMKK20.71467081
69PAK30.70589910
70STK380.69020639
71RAF10.68210416
72DYRK1A0.67868910
73ACVR1B0.65425298
74KSR10.61564760
75MAP3K130.60256701
76TGFBR20.59309983
77IKBKB0.56738847
78MELK0.55445205
79EGFR0.55012856
80KSR20.54583296
81PDGFRB0.53097765
82PDK10.51771479
83FGFR40.48219390
84CAMK1D0.45695334
85RPS6KA50.43588151
86BRD40.42938870
87RPS6KA40.42055420
88PRKAA20.41869336
89SIK30.41112804
90PTK60.40574196
91SIK20.40532310
92CAMK40.40286871
93ADRBK10.40142306
94HIPK20.38653505
95FYN0.38618811
96CHUK0.38400224
97PRPF4B0.37888385
98CDC42BPA0.36594643
99KIT0.36359733
100MAP3K110.35701661

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.96852356
2B cell receptor signaling pathway_Homo sapiens_hsa046622.68335954
3Osteoclast differentiation_Homo sapiens_hsa043802.48168074
4Non-small cell lung cancer_Homo sapiens_hsa052232.39405017
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.31762772
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.28645349
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.25276459
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.12021174
9T cell receptor signaling pathway_Homo sapiens_hsa046602.04509579
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.98501612
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.97808149
12Measles_Homo sapiens_hsa051621.87910890
13Tuberculosis_Homo sapiens_hsa051521.87076015
14Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.79845081
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.77274797
16Malaria_Homo sapiens_hsa051441.72276750
17Legionellosis_Homo sapiens_hsa051341.69438650
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.64401980
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.62548934
20Dorso-ventral axis formation_Homo sapiens_hsa043201.62132799
21Staphylococcus aureus infection_Homo sapiens_hsa051501.58735868
22FoxO signaling pathway_Homo sapiens_hsa040681.51152985
23Primary immunodeficiency_Homo sapiens_hsa053401.49098861
24Hepatitis B_Homo sapiens_hsa051611.46113061
25Chemokine signaling pathway_Homo sapiens_hsa040621.46070123
26Hematopoietic cell lineage_Homo sapiens_hsa046401.44275179
27Acute myeloid leukemia_Homo sapiens_hsa052211.42386969
28Prolactin signaling pathway_Homo sapiens_hsa049171.41497590
29Toxoplasmosis_Homo sapiens_hsa051451.40818660
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38547429
31Influenza A_Homo sapiens_hsa051641.38465769
32Pancreatic cancer_Homo sapiens_hsa052121.37169576
33TNF signaling pathway_Homo sapiens_hsa046681.33903868
34Platelet activation_Homo sapiens_hsa046111.32396918
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28374500
36Endometrial cancer_Homo sapiens_hsa052131.27652677
37Apoptosis_Homo sapiens_hsa042101.26151176
38Chronic myeloid leukemia_Homo sapiens_hsa052201.23420121
39Inositol phosphate metabolism_Homo sapiens_hsa005621.18810914
40VEGF signaling pathway_Homo sapiens_hsa043701.17144473
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16946643
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.16118004
43Renal cell carcinoma_Homo sapiens_hsa052111.15770127
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15700830
45mTOR signaling pathway_Homo sapiens_hsa041501.11410042
46Hepatitis C_Homo sapiens_hsa051601.09613226
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.07778257
48Graft-versus-host disease_Homo sapiens_hsa053321.02664164
49Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01047968
50Herpes simplex infection_Homo sapiens_hsa051680.94925995
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93066146
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.92539666
53Glioma_Homo sapiens_hsa052140.88780077
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88242890
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87191198
56ErbB signaling pathway_Homo sapiens_hsa040120.85852640
57Notch signaling pathway_Homo sapiens_hsa043300.81611910
58Allograft rejection_Homo sapiens_hsa053300.81385758
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80068066
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78184136
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78082376
62Viral carcinogenesis_Homo sapiens_hsa052030.74733740
63Insulin resistance_Homo sapiens_hsa049310.74525907
64HIF-1 signaling pathway_Homo sapiens_hsa040660.74476145
65Regulation of autophagy_Homo sapiens_hsa041400.74159391
66Prostate cancer_Homo sapiens_hsa052150.72134046
67Autoimmune thyroid disease_Homo sapiens_hsa053200.71631748
68Fatty acid biosynthesis_Homo sapiens_hsa000610.70169259
69Type II diabetes mellitus_Homo sapiens_hsa049300.69673599
70Colorectal cancer_Homo sapiens_hsa052100.65817377
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65071642
72Choline metabolism in cancer_Homo sapiens_hsa052310.64987855
73MicroRNAs in cancer_Homo sapiens_hsa052060.64468670
74Epstein-Barr virus infection_Homo sapiens_hsa051690.63379502
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62409546
76GnRH signaling pathway_Homo sapiens_hsa049120.62219163
77Antigen processing and presentation_Homo sapiens_hsa046120.61512633
78HTLV-I infection_Homo sapiens_hsa051660.61012587
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59780084
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.57771268
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57722436
82Small cell lung cancer_Homo sapiens_hsa052220.56884574
83MAPK signaling pathway_Homo sapiens_hsa040100.55629061
84Phagosome_Homo sapiens_hsa041450.55352294
85Long-term potentiation_Homo sapiens_hsa047200.55057343
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54914119
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54884278
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54498743
89African trypanosomiasis_Homo sapiens_hsa051430.52970980
90Thyroid cancer_Homo sapiens_hsa052160.52310259
91Proteoglycans in cancer_Homo sapiens_hsa052050.49637819
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49268905
93p53 signaling pathway_Homo sapiens_hsa041150.47950694
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.47805950
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47289251
96Pertussis_Homo sapiens_hsa051330.46566622
97AMPK signaling pathway_Homo sapiens_hsa041520.45844524
98Viral myocarditis_Homo sapiens_hsa054160.44170347
99Cholinergic synapse_Homo sapiens_hsa047250.43792574
100Amoebiasis_Homo sapiens_hsa051460.42745576

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