ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	dopamine transport (GO:0015872)	8.02671409
2	dopamine biosynthetic process (GO:0042416)	5.71138688
3	catecholamine transport (GO:0051937)	5.53631358
4	monoamine transport (GO:0015844)	4.79797204
5	inositol phosphate catabolic process (GO:0071545)	4.50631429
6	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	4.30704123
7	negative regulation of neurotransmitter transport (GO:0051589)	4.10580428
8	DNA double-strand break processing (GO:0000729)	4.00996611
9	catechol-containing compound biosynthetic process (GO:0009713)	4.00113065
10	catecholamine biosynthetic process (GO:0042423)	4.00113065
11	tyrosine metabolic process (GO:0006570)	3.94356775
12	norepinephrine metabolic process (GO:0042415)	3.93366672
13	phenol-containing compound catabolic process (GO:0019336)	3.90779020
14	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.84780922
15	response to pheromone (GO:0019236)	3.80097407
16	presynaptic membrane organization (GO:0097090)	3.80094163
17	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.72727609
18	inositol phosphate dephosphorylation (GO:0046855)	3.72727609
19	limb bud formation (GO:0060174)	3.60634006
20	regulation of timing of cell differentiation (GO:0048505)	3.47418046
21	replication fork processing (GO:0031297)	3.44598003
22	rRNA methylation (GO:0031167)	3.43143596
23	polyol catabolic process (GO:0046174)	3.43130122
24	response to cocaine (GO:0042220)	3.41715424
25	resolution of meiotic recombination intermediates (GO:0000712)	3.39449415
26	presynaptic membrane assembly (GO:0097105)	3.38273194
27	prepulse inhibition (GO:0060134)	3.36820127
28	regulation of development, heterochronic (GO:0040034)	3.32495472
29	single strand break repair (GO:0000012)	3.25865763
30	neurotransmitter biosynthetic process (GO:0042136)	3.23022326
31	regulation of hypersensitivity (GO:0002883)	3.22973843
32	attachment of spindle microtubules to kinetochore (GO:0008608)	3.20971598
33	nerve growth factor signaling pathway (GO:0038180)	3.20719678
34	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.18379694
35	CDP-diacylglycerol biosynthetic process (GO:0016024)	3.15632106
36	positive regulation of mast cell activation involved in immune response (GO:0033008)	3.11716847
37	positive regulation of mast cell degranulation (GO:0043306)	3.11716847
38	establishment of mitochondrion localization (GO:0051654)	3.10739258
39	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.07170094
40	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.05617244
41	dopamine metabolic process (GO:0042417)	3.01601764
42	neurotransmitter-gated ion channel clustering (GO:0072578)	3.00363592
43	synaptic transmission, dopaminergic (GO:0001963)	2.99010838
44	regulation of collateral sprouting (GO:0048670)	2.98486931
45	ubiquinone biosynthetic process (GO:0006744)	2.97818360
46	regulation of catecholamine metabolic process (GO:0042069)	2.95931572
47	regulation of dopamine metabolic process (GO:0042053)	2.95931572
48	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.95267698
49	negative regulation of axon guidance (GO:1902668)	2.94636275
50	brain morphogenesis (GO:0048854)	2.89294854
51	Rap protein signal transduction (GO:0032486)	2.89207474
52	ubiquinone metabolic process (GO:0006743)	2.88931633
53	rRNA modification (GO:0000154)	2.86198544
54	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.85571554
55	multicellular organismal aging (GO:0010259)	2.84129035
56	neurotransmitter metabolic process (GO:0042133)	2.83667179
57	positive regulation of male gonad development (GO:2000020)	2.80895344
58	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.80672362
59	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.77845558
60	response to amphetamine (GO:0001975)	2.76184999
61	protein localization to synapse (GO:0035418)	2.75913428
62	serotonin metabolic process (GO:0042428)	2.74714693
63	DNA ligation (GO:0006266)	2.74160390
64	regulation of male gonad development (GO:2000018)	2.69965281
65	protein polyglutamylation (GO:0018095)	2.68362633
66	neural tube formation (GO:0001841)	2.66572665
67	regulation of coenzyme metabolic process (GO:0051196)	2.65245487
68	regulation of cofactor metabolic process (GO:0051193)	2.65245487
69	positive regulation of mitochondrial fission (GO:0090141)	2.61571647
70	cerebral cortex cell migration (GO:0021795)	2.60622787
71	respiratory chain complex IV assembly (GO:0008535)	2.59580984
72	retinal cone cell development (GO:0046549)	2.59133677
73	cerebral cortex radially oriented cell migration (GO:0021799)	2.57557863
74	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.57162876
75	L-phenylalanine metabolic process (GO:0006558)	2.57162876
76	pyrimidine nucleobase catabolic process (GO:0006208)	2.55033854
77	neuron cell-cell adhesion (GO:0007158)	2.52339896
78	CDP-diacylglycerol metabolic process (GO:0046341)	2.51596468
79	alkaloid metabolic process (GO:0009820)	2.51056289
80	axoneme assembly (GO:0035082)	2.50056442
81	negative regulation of neurotransmitter secretion (GO:0046929)	2.49100870
82	phenol-containing compound biosynthetic process (GO:0046189)	2.48309720
83	primary amino compound metabolic process (GO:1901160)	2.47942100
84	mitochondrion transport along microtubule (GO:0047497)	2.47068606
85	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.47068606
86	protein-cofactor linkage (GO:0018065)	2.46590056
87	striatum development (GO:0021756)	2.45526375
88	histone H2A acetylation (GO:0043968)	2.43244293
89	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.40295843
90	L-phenylalanine catabolic process (GO:0006559)	2.40295843
91	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.35437472
92	gamma-aminobutyric acid transport (GO:0015812)	2.33658281
93	synapsis (GO:0007129)	2.33557769
94	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.33403489
95	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.33312610
96	regulation of hexokinase activity (GO:1903299)	2.32526639
97	regulation of glucokinase activity (GO:0033131)	2.32526639
98	microtubule polymerization or depolymerization (GO:0031109)	2.31472801
99	positive regulation of mast cell activation (GO:0033005)	2.31095775
100	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	2.29950908

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.76750151
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.49010506
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.23459493
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.22114971
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.19424406
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.83021519
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.79899069
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.73049190
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.59719894
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.42124010
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.38392622
12	FUS_26573619_Chip-Seq_HEK293_Human	2.36482283
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.32388370
14	VDR_22108803_ChIP-Seq_LS180_Human	2.19900477
15	P300_19829295_ChIP-Seq_ESCs_Human	2.17634520
16	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.13720780
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.10895379
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.05611248
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.03641151
20	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.00708104
21	EWS_26573619_Chip-Seq_HEK293_Human	1.97310926
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.91902215
23	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.91454252
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.90955354
25	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.90775573
26	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.86133147
27	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.85805577
28	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.83932351
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.76437721
30	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.73268592
31	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.72013756
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.71951744
33	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.68652994
34	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.59547435
35	STAT3_23295773_ChIP-Seq_U87_Human	1.55411264
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.54004319
37	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.52372647
38	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.49694041
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.48082554
40	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.47066615
41	AR_25329375_ChIP-Seq_VCAP_Human	1.45072858
42	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.44417446
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.43400028
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41875604
45	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.40786952
46	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.38939330
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35539536
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35539536
49	RUNX2_22187159_ChIP-Seq_PCA_Human	1.35509047
50	TCF4_23295773_ChIP-Seq_U87_Human	1.32696943
51	TCF4_22108803_ChIP-Seq_LS180_Human	1.30928698
52	TP53_22573176_ChIP-Seq_HFKS_Human	1.28866873
53	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.28228666
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.27947437
55	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.27156697
56	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.25200801
57	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.23664162
58	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.23196604
59	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22981742
60	P53_22387025_ChIP-Seq_ESCs_Mouse	1.21630280
61	EZH2_22144423_ChIP-Seq_EOC_Human	1.21059802
62	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.20773123
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.20431179
64	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.19570397
65	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.16813388
66	ELK1_19687146_ChIP-ChIP_HELA_Human	1.16691947
67	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.16193129
68	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.15619419
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14663704
70	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.14439729
71	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.13281894
72	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.12315547
73	P300_18555785_Chip-Seq_ESCs_Mouse	1.11740535
74	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.11611818
75	TP53_18474530_ChIP-ChIP_U2OS_Human	1.11440797
76	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.11252578
77	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11252578
78	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11130720
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10734209
80	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.10095662
81	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.08848280
82	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.07766083
83	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.07333956
84	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.07063161
85	REST_21632747_ChIP-Seq_MESCs_Mouse	1.06264123
86	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.06247898
87	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06185082
88	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05767065
89	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.05633502
90	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05407540
91	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.04614760
92	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.04006820
93	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.03634126
94	CBP_20019798_ChIP-Seq_JUKART_Human	1.02277991
95	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02277991
96	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.02181072
97	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.01635656
98	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.98974215
99	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.98911490
100	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.98170016

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.59646892
2	MP0003195_calcinosis	3.01252638
3	MP0001905_abnormal_dopamine_level	2.96970041
4	MP0009046_muscle_twitch	2.92184358
5	MP0008877_abnormal_DNA_methylation	2.52393191
6	MP0004133_heterotaxia	2.27458142
7	MP0006054_spinal_hemorrhage	2.21781256
8	MP0003787_abnormal_imprinting	2.21408179
9	MP0002837_dystrophic_cardiac_calcinosis	2.09530622
10	MP0001968_abnormal_touch/_nociception	2.08753925
11	MP0004270_analgesia	2.06402990
12	MP0003890_abnormal_embryonic-extraembry	1.99768167
13	MP0009697_abnormal_copulation	1.98601718
14	MP0006292_abnormal_olfactory_placode	1.96535833
15	MP0002736_abnormal_nociception_after	1.95719954
16	MP0001529_abnormal_vocalization	1.95228347
17	MP0000383_abnormal_hair_follicle	1.84647125
18	MP0004924_abnormal_behavior	1.84330898
19	MP0005386_behavior/neurological_phenoty	1.84330898
20	MP0002254_reproductive_system_inflammat	1.75577311
21	MP0005551_abnormal_eye_electrophysiolog	1.70952328
22	MP0002102_abnormal_ear_morphology	1.67212249
23	MP0002938_white_spotting	1.65917060
24	MP0000631_abnormal_neuroendocrine_gland	1.58880642
25	MP0006072_abnormal_retinal_apoptosis	1.58613271
26	MP0001188_hyperpigmentation	1.58568340
27	MP0000372_irregular_coat_pigmentation	1.57672145
28	MP0009745_abnormal_behavioral_response	1.57523920
29	MP0003121_genomic_imprinting	1.49203164
30	MP0008995_early_reproductive_senescence	1.48769116
31	MP0001486_abnormal_startle_reflex	1.47962920
32	MP0000778_abnormal_nervous_system	1.47768215
33	MP0008789_abnormal_olfactory_epithelium	1.45198632
34	MP0005499_abnormal_olfactory_system	1.45183532
35	MP0005394_taste/olfaction_phenotype	1.45183532
36	MP0000427_abnormal_hair_cycle	1.41268634
37	MP0003635_abnormal_synaptic_transmissio	1.40478995
38	MP0002572_abnormal_emotion/affect_behav	1.39133272
39	MP0001177_atelectasis	1.37768746
40	MP0010678_abnormal_skin_adnexa	1.37142480
41	MP0002734_abnormal_mechanical_nocicepti	1.35768807
42	MP0006276_abnormal_autonomic_nervous	1.35654139
43	MP0005174_abnormal_tail_pigmentation	1.35279388
44	MP0000516_abnormal_urinary_system	1.34433008
45	MP0005367_renal/urinary_system_phenotyp	1.34433008
46	MP0000569_abnormal_digit_pigmentation	1.31971846
47	MP0008872_abnormal_physiological_respon	1.27608925
48	MP0002822_catalepsy	1.27009779
49	MP0001984_abnormal_olfaction	1.21713118
50	MP0002751_abnormal_autonomic_nervous	1.20156007
51	MP0003786_premature_aging	1.18903429
52	MP0005379_endocrine/exocrine_gland_phen	1.18713977
53	MP0005253_abnormal_eye_physiology	1.18581066
54	MP0004215_abnormal_myocardial_fiber	1.16163479
55	MP0008058_abnormal_DNA_repair	1.14760992
56	MP0002063_abnormal_learning/memory/cond	1.12190316
57	MP0005084_abnormal_gallbladder_morpholo	1.08616522
58	MP0003937_abnormal_limbs/digits/tail_de	1.08440745
59	MP0006035_abnormal_mitochondrial_morpho	1.07591432
60	MP0003718_maternal_effect	1.07392079
61	MP0002272_abnormal_nervous_system	1.05629260
62	MP0002234_abnormal_pharynx_morphology	1.04966182
63	MP0004885_abnormal_endolymph	1.03739899
64	MP0002064_seizures	1.03579057
65	MP0002160_abnormal_reproductive_system	1.03500377
66	MP0002557_abnormal_social/conspecific_i	1.03276178
67	MP0001986_abnormal_taste_sensitivity	1.01790119
68	MP0003123_paternal_imprinting	1.01588682
69	MP0005360_urolithiasis	1.00271531
70	MP0002067_abnormal_sensory_capabilities	0.96977036
71	MP0002184_abnormal_innervation	0.96788369
72	MP0003119_abnormal_digestive_system	0.92454826
73	MP0003567_abnormal_fetal_cardiomyocyte	0.92241561
74	MP0004811_abnormal_neuron_physiology	0.90456577
75	MP0001270_distended_abdomen	0.90455556
76	MP0002233_abnormal_nose_morphology	0.90247078
77	MP0002882_abnormal_neuron_morphology	0.88244855
78	MP0002876_abnormal_thyroid_physiology	0.87427601
79	MP0010030_abnormal_orbit_morphology	0.86896315
80	MP0003011_delayed_dark_adaptation	0.86736181
81	MP0002752_abnormal_somatic_nervous	0.85677594
82	MP0002229_neurodegeneration	0.85122880
83	MP0002638_abnormal_pupillary_reflex	0.84784072
84	MP0004084_abnormal_cardiac_muscle	0.84611033
85	MP0005646_abnormal_pituitary_gland	0.84343027
86	MP0010094_abnormal_chromosome_stability	0.82247801
87	MP0000462_abnormal_digestive_system	0.79950339
88	MP0000639_abnormal_adrenal_gland	0.79430580
89	MP0002735_abnormal_chemical_nociception	0.77995458
90	MP0000358_abnormal_cell_content/	0.76439024
91	MP0001501_abnormal_sleep_pattern	0.75272178
92	MP0003861_abnormal_nervous_system	0.74974571
93	MP0000049_abnormal_middle_ear	0.74270542
94	MP0001970_abnormal_pain_threshold	0.74073458
95	MP0002653_abnormal_ependyma_morphology	0.73146949
96	MP0003693_abnormal_embryo_hatching	0.73089656
97	MP0000613_abnormal_salivary_gland	0.72955052
98	MP0003633_abnormal_nervous_system	0.71660730
99	MP0005195_abnormal_posterior_eye	0.71345692
100	MP0002066_abnormal_motor_capabilities/c	0.70201359

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Limb dystonia (HP:0002451)	7.42923781
2	Dyskinesia (HP:0100660)	4.13080568
3	Hypothermia (HP:0002045)	3.98224924
4	Intestinal atresia (HP:0011100)	3.49668504
5	Delayed gross motor development (HP:0002194)	3.48413477
6	Drooling (HP:0002307)	3.43532893
7	Retinal dysplasia (HP:0007973)	3.33174947
8	Absent speech (HP:0001344)	3.30433153
9	Focal motor seizures (HP:0011153)	3.27806150
10	Excessive salivation (HP:0003781)	3.10902643
11	Type II lissencephaly (HP:0007260)	3.05909505
12	Abnormality of midbrain morphology (HP:0002418)	3.04366974
13	Molar tooth sign on MRI (HP:0002419)	3.04366974
14	Morphological abnormality of the pyramidal tract (HP:0002062)	2.94450806
15	Abnormality of the parathyroid morphology (HP:0011766)	2.89878859
16	Hypokinesia (HP:0002375)	2.79693987
17	Double outlet right ventricle (HP:0001719)	2.72772369
18	Congenital malformation of the right heart (HP:0011723)	2.72772369
19	Renal cortical cysts (HP:0000803)	2.71587403
20	Focal seizures (HP:0007359)	2.65170323
21	Oligodactyly (hands) (HP:0001180)	2.55002021
22	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.53806514
23	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.53806514
24	Nephronophthisis (HP:0000090)	2.51735038
25	Diminished movement (HP:0002374)	2.48045716
26	Mutism (HP:0002300)	2.47431938
27	Abnormality of macular pigmentation (HP:0008002)	2.45403301
28	Progressive inability to walk (HP:0002505)	2.42808899
29	Muscular hypotonia of the trunk (HP:0008936)	2.40102692
30	True hermaphroditism (HP:0010459)	2.39923284
31	Chronic hepatic failure (HP:0100626)	2.32977093
32	Pancreatic cysts (HP:0001737)	2.29116532
33	Impaired vibration sensation in the lower limbs (HP:0002166)	2.28920452
34	Abnormality of the corticospinal tract (HP:0002492)	2.28918173
35	Volvulus (HP:0002580)	2.28568471
36	Akinesia (HP:0002304)	2.28532403
37	Broad-based gait (HP:0002136)	2.27196988
38	Medial flaring of the eyebrow (HP:0010747)	2.26890491
39	Inability to walk (HP:0002540)	2.26122761
40	Lissencephaly (HP:0001339)	2.25521817
41	Pancreatic fibrosis (HP:0100732)	2.24183488
42	Supernumerary spleens (HP:0009799)	2.23504158
43	Abnormality of the astrocytes (HP:0100707)	2.21773975
44	Astrocytoma (HP:0009592)	2.21773975
45	Anosmia (HP:0000458)	2.14411823
46	Glioma (HP:0009733)	2.12388539
47	Abnormality of the renal cortex (HP:0011035)	2.10511066
48	Gaze-evoked nystagmus (HP:0000640)	2.07924817
49	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.03832793
50	Narrow forehead (HP:0000341)	2.03109098
51	Protruding tongue (HP:0010808)	1.99178803
52	Abnormality of the renal medulla (HP:0100957)	1.98570349
53	Optic nerve hypoplasia (HP:0000609)	1.95813758
54	Aqueductal stenosis (HP:0002410)	1.94208661
55	Gonadal dysgenesis (HP:0000133)	1.93941518
56	Gait imbalance (HP:0002141)	1.93068181
57	Gastroesophageal reflux (HP:0002020)	1.89913529
58	Inappropriate behavior (HP:0000719)	1.89194881
59	Genital tract atresia (HP:0001827)	1.87287784
60	Dandy-Walker malformation (HP:0001305)	1.86592974
61	Abnormality of alanine metabolism (HP:0010916)	1.85780787
62	Hyperalaninemia (HP:0003348)	1.85780787
63	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.85780787
64	Gonadotropin excess (HP:0000837)	1.85298376
65	Anophthalmia (HP:0000528)	1.82777151
66	Occipital encephalocele (HP:0002085)	1.81930952
67	Vaginal atresia (HP:0000148)	1.81444235
68	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.81337047
69	Renal hypoplasia (HP:0000089)	1.81193499
70	Oculomotor apraxia (HP:0000657)	1.79792140
71	Congenital primary aphakia (HP:0007707)	1.79456389
72	Nephrogenic diabetes insipidus (HP:0009806)	1.79233880
73	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.78316830
74	Abnormality of the fovea (HP:0000493)	1.78165340
75	Thyroiditis (HP:0100646)	1.77850270
76	Ependymoma (HP:0002888)	1.77840209
77	Neoplasm of the adrenal gland (HP:0100631)	1.77116209
78	Hepatoblastoma (HP:0002884)	1.76288795
79	Prolonged partial thromboplastin time (HP:0003645)	1.74968197
80	Short tibia (HP:0005736)	1.74360925
81	Neoplasm of the adrenal cortex (HP:0100641)	1.73877714
82	Cerebellar dysplasia (HP:0007033)	1.72959060
83	Abnormality of the antihelix (HP:0009738)	1.72846178
84	Adactyly (HP:0009776)	1.72062635
85	Decreased testicular size (HP:0008734)	1.71518417
86	Bradykinesia (HP:0002067)	1.71241943
87	Generalized tonic-clonic seizures (HP:0002069)	1.69694724
88	Abnormality of salivation (HP:0100755)	1.68785930
89	Hypobetalipoproteinemia (HP:0003563)	1.68510354
90	Male pseudohermaphroditism (HP:0000037)	1.68185431
91	Broad alveolar ridges (HP:0000187)	1.67982409
92	Supranuclear gaze palsy (HP:0000605)	1.67707065
93	Lymphangioma (HP:0100764)	1.67624600
94	Gastrointestinal atresia (HP:0002589)	1.66582199
95	Severe muscular hypotonia (HP:0006829)	1.66338135
96	Oligodactyly (HP:0012165)	1.66330826
97	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.66247796
98	Febrile seizures (HP:0002373)	1.66176179
99	Abnormal lung lobation (HP:0002101)	1.65641613
100	Specific learning disability (HP:0001328)	1.64338477

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BUB1	3.74166584
2	FRK	3.43725026
3	MAPK13	3.30300515
4	CSNK1G2	3.20079754
5	CASK	3.04949621
6	CSNK1G3	2.91350117
7	WNK3	2.72143063
8	MARK1	2.70068920
9	PRKD3	2.64232295
10	CSNK1G1	2.55760555
11	PINK1	2.40102443
12	TRIM28	2.27763722
13	STK24	2.22116585
14	MAP3K4	1.82834162
15	MAPKAPK5	1.82028067
16	EPHA4	1.78940426
17	MKNK2	1.74929437
18	PLK2	1.73596557
19	STK39	1.70541502
20	BRSK2	1.55384585
21	CCNB1	1.51238143
22	SRPK1	1.48228467
23	CSNK1A1L	1.44535924
24	PAK3	1.41844898
25	ZAK	1.40347224
26	PLK3	1.34746811
27	MET	1.34214838
28	BCR	1.32871537
29	MKNK1	1.30012951
30	MAP3K12	1.29801629
31	BMPR1B	1.28543957
32	MAP2K7	1.25618194
33	WNK4	1.13121259
34	CAMK2B	1.10833084
35	PBK	1.09500796
36	PTK2B	1.07666474
37	GRK1	1.06742126
38	ERBB4	1.06650737
39	OXSR1	1.04934859
40	PLK4	1.00687151
41	PRKCG	0.97574440
42	NUAK1	0.95289531
43	NEK1	0.94619742
44	PRKCE	0.93393352
45	CAMK2D	0.91934896
46	GRK5	0.90938962
47	CAMKK2	0.90453727
48	CAMK2A	0.89647450
49	MAP4K2	0.86655586
50	NTRK3	0.86519642
51	STK3	0.82531434
52	PNCK	0.80970345
53	UHMK1	0.79883972
54	TNK2	0.77054030
55	MINK1	0.75684480
56	ERBB3	0.75225483
57	ACVR1B	0.73434319
58	FGFR2	0.73271060
59	MAP2K4	0.72982087
60	PKN1	0.71926214
61	MAP3K9	0.71872816
62	CDK19	0.71150594
63	PHKG1	0.68265681
64	PHKG2	0.68265681
65	CLK1	0.68167587
66	CAMK2G	0.66054112
67	PLK1	0.65448951
68	DYRK2	0.62103653
69	BCKDK	0.61866491
70	VRK1	0.60838981
71	ATM	0.56550774
72	MAP3K2	0.55878636
73	CDK18	0.55671667
74	STK38L	0.54964854
75	CSNK1D	0.54769971
76	CSNK1A1	0.51178138
77	BRSK1	0.51014718
78	ADRBK2	0.50741979
79	TTK	0.50463442
80	PDK2	0.49310307
81	CDK15	0.47638612
82	PRKG1	0.47468151
83	CDK14	0.45589658
84	CDK11A	0.44905535
85	CDK5	0.44647066
86	YES1	0.43899907
87	TAOK1	0.43343730
88	INSRR	0.42979442
89	DYRK1A	0.42880728
90	ROCK1	0.42606303
91	CAMK4	0.40647776
92	PRKCZ	0.38133537
93	EIF2AK1	0.36334220
94	ATR	0.35809072
95	DAPK2	0.33977399
96	PRKG2	0.32366616
97	PRKACB	0.30521833
98	PRKACA	0.27633611
99	AKT3	0.26756001
100	PRKAA1	0.26739682

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	3.73579736
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.20645403
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.82115772
4	Cocaine addiction_Homo sapiens_hsa05030	2.68660675
5	Folate biosynthesis_Homo sapiens_hsa00790	2.30387969
6	Propanoate metabolism_Homo sapiens_hsa00640	2.28442551
7	Amphetamine addiction_Homo sapiens_hsa05031	2.04025775
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.99636167
9	Collecting duct acid secretion_Homo sapiens_hsa04966	1.96092189
10	Fatty acid elongation_Homo sapiens_hsa00062	1.87292628
11	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.82913989
12	Nicotine addiction_Homo sapiens_hsa05033	1.73560492
13	Steroid biosynthesis_Homo sapiens_hsa00100	1.73511101
14	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.72045730
15	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.69395161
16	Dopaminergic synapse_Homo sapiens_hsa04728	1.68518788
17	Parkinsons disease_Homo sapiens_hsa05012	1.67405234
18	Protein export_Homo sapiens_hsa03060	1.60094051
19	Regulation of autophagy_Homo sapiens_hsa04140	1.56420774
20	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.51220070
21	Butanoate metabolism_Homo sapiens_hsa00650	1.48714804
22	Phototransduction_Homo sapiens_hsa04744	1.42547105
23	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.40053764
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.37978783
25	Basal transcription factors_Homo sapiens_hsa03022	1.36949765
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32154294
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.28860889
28	Taste transduction_Homo sapiens_hsa04742	1.28846579
29	Peroxisome_Homo sapiens_hsa04146	1.27752737
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.25813218
31	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.24139592
32	Fatty acid metabolism_Homo sapiens_hsa01212	1.22073646
33	Proteasome_Homo sapiens_hsa03050	1.17078269
34	Oxidative phosphorylation_Homo sapiens_hsa00190	1.15489209
35	Selenocompound metabolism_Homo sapiens_hsa00450	1.13117067
36	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.11316631
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07037916
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.06690103
39	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.06257064
40	Circadian entrainment_Homo sapiens_hsa04713	1.02944798
41	beta-Alanine metabolism_Homo sapiens_hsa00410	0.97615920
42	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.97274314
43	Glutamatergic synapse_Homo sapiens_hsa04724	0.96190574
44	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.95925858
45	Oocyte meiosis_Homo sapiens_hsa04114	0.95799906
46	Insulin secretion_Homo sapiens_hsa04911	0.95769526
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.95480458
48	Sulfur metabolism_Homo sapiens_hsa00920	0.93366953
49	Sphingolipid metabolism_Homo sapiens_hsa00600	0.92419475
50	Homologous recombination_Homo sapiens_hsa03440	0.90364757
51	GABAergic synapse_Homo sapiens_hsa04727	0.90293091
52	Axon guidance_Homo sapiens_hsa04360	0.90151709
53	Nitrogen metabolism_Homo sapiens_hsa00910	0.88758154
54	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.87629767
55	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.83998128
56	Tyrosine metabolism_Homo sapiens_hsa00350	0.82317159
57	RNA degradation_Homo sapiens_hsa03018	0.78500444
58	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.77776593
59	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.77704730
60	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.74979315
61	Long-term depression_Homo sapiens_hsa04730	0.73035497
62	Serotonergic synapse_Homo sapiens_hsa04726	0.68146111
63	Pyruvate metabolism_Homo sapiens_hsa00620	0.67176485
64	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.66758651
65	Arginine biosynthesis_Homo sapiens_hsa00220	0.66426596
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.65395354
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.64428121
68	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.63628888
69	Vibrio cholerae infection_Homo sapiens_hsa05110	0.63188740
70	Metabolic pathways_Homo sapiens_hsa01100	0.62487849
71	Fatty acid degradation_Homo sapiens_hsa00071	0.61307000
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60986594
73	Circadian rhythm_Homo sapiens_hsa04710	0.60214201
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.59947390
75	Base excision repair_Homo sapiens_hsa03410	0.59116639
76	Renin secretion_Homo sapiens_hsa04924	0.58709498
77	RNA transport_Homo sapiens_hsa03013	0.58585722
78	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.58306534
79	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.57761531
80	RNA polymerase_Homo sapiens_hsa03020	0.56336517
81	Hippo signaling pathway_Homo sapiens_hsa04390	0.53669783
82	Basal cell carcinoma_Homo sapiens_hsa05217	0.53239971
83	Wnt signaling pathway_Homo sapiens_hsa04310	0.52752570
84	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.50858181
85	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.50041919
86	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.48862700
87	Salivary secretion_Homo sapiens_hsa04970	0.48642996
88	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.46163239
89	Huntingtons disease_Homo sapiens_hsa05016	0.42566159
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.42564970
91	ABC transporters_Homo sapiens_hsa02010	0.41827954
92	Morphine addiction_Homo sapiens_hsa05032	0.40305342
93	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.40098997
94	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.40025747
95	Retinol metabolism_Homo sapiens_hsa00830	0.39558201
96	Gap junction_Homo sapiens_hsa04540	0.39166055
97	Nucleotide excision repair_Homo sapiens_hsa03420	0.36832491
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36671555
99	cAMP signaling pathway_Homo sapiens_hsa04024	0.36548016
100	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.36329543

RPS20P33

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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