ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sphingoid metabolic process (GO:0046519)	9.08261160
2	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	6.61742941
3	DNA methylation involved in gamete generation (GO:0043046)	6.44953482
4	maturation of SSU-rRNA (GO:0030490)	6.28042474
5	lipopolysaccharide biosynthetic process (GO:0009103)	6.06214077
6	regulation of meiosis I (GO:0060631)	5.70751347
7	translational termination (GO:0006415)	5.61323116
8	ribosomal small subunit biogenesis (GO:0042274)	5.60901768
9	viral transcription (GO:0019083)	5.51212663
10	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	5.50202159
11	protein-chromophore linkage (GO:0018298)	5.47137226
12	piRNA metabolic process (GO:0034587)	5.22382054
13	ribosomal small subunit assembly (GO:0000028)	5.13735127
14	SMAD protein complex assembly (GO:0007183)	5.07845791
15	sulfate transmembrane transport (GO:1902358)	5.07708076
16	lipopolysaccharide metabolic process (GO:0008653)	5.07140858
17	negative regulation of cell cycle G2/M phase transition (GO:1902750)	4.94227333
18	positive regulation of developmental pigmentation (GO:0048087)	4.84904638
19	meiotic chromosome segregation (GO:0045132)	4.41830924
20	translational elongation (GO:0006414)	4.41289607
21	sulfate transport (GO:0008272)	4.29517434
22	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.29030794
23	ribonucleoprotein complex disassembly (GO:0032988)	4.25688627
24	cotranslational protein targeting to membrane (GO:0006613)	4.20861604
25	regulation of pigment cell differentiation (GO:0050932)	4.18281568
26	protein targeting to ER (GO:0045047)	4.15461739
27	cellular protein complex disassembly (GO:0043624)	4.14786965
28	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.09509589
29	L-phenylalanine catabolic process (GO:0006559)	4.09509589
30	regulation of protein glycosylation (GO:0060049)	4.02027301
31	viral life cycle (GO:0019058)	4.00585621
32	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.00026031
33	lysine catabolic process (GO:0006554)	3.85827082
34	lysine metabolic process (GO:0006553)	3.85827082
35	heme transport (GO:0015886)	3.85503277
36	protein localization to endoplasmic reticulum (GO:0070972)	3.82383300
37	protein neddylation (GO:0045116)	3.75975867
38	organelle disassembly (GO:1903008)	3.68732864
39	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.64009377
40	notochord development (GO:0030903)	3.63728866
41	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.60182595
42	negative regulation of glycoprotein biosynthetic process (GO:0010561)	3.58445417
43	macromolecular complex disassembly (GO:0032984)	3.55861676
44	centriole replication (GO:0007099)	3.55477138
45	protein complex disassembly (GO:0043241)	3.50531374
46	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	3.47106185
47	serotonin receptor signaling pathway (GO:0007210)	3.41511417
48	tyrosine metabolic process (GO:0006570)	3.36580095
49	DNA deamination (GO:0045006)	3.33780707
50	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.33339877
51	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.31251874
52	paraxial mesoderm development (GO:0048339)	3.30688477
53	cornea development in camera-type eye (GO:0061303)	3.27410857
54	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.26521880
55	rhodopsin mediated signaling pathway (GO:0016056)	3.25140623
56	aspartate family amino acid catabolic process (GO:0009068)	3.17257308
57	translational initiation (GO:0006413)	3.16777047
58	glycerol metabolic process (GO:0006071)	3.16502080
59	cell proliferation in forebrain (GO:0021846)	3.13476708
60	behavioral response to nicotine (GO:0035095)	3.10060028
61	regulation of transforming growth factor beta2 production (GO:0032909)	3.06619713
62	iron coordination entity transport (GO:1901678)	3.06522820
63	L-phenylalanine metabolic process (GO:0006558)	3.06011986
64	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.06011986
65	DNA damage induced protein phosphorylation (GO:0006975)	3.04864654
66	cell wall macromolecule catabolic process (GO:0016998)	2.99445789
67	negative regulation of stem cell proliferation (GO:2000647)	2.98084688
68	aromatic amino acid family catabolic process (GO:0009074)	2.97975363
69	indolalkylamine metabolic process (GO:0006586)	2.90809133
70	GTP biosynthetic process (GO:0006183)	2.89712519
71	regulation of neuroblast proliferation (GO:1902692)	2.82799897
72	alditol metabolic process (GO:0019400)	2.80909416
73	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.79751058
74	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.78188693
75	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.78188693
76	aromatic amino acid family metabolic process (GO:0009072)	2.78165952
77	protein retention in ER lumen (GO:0006621)	2.77662578
78	positive regulation of meiosis (GO:0045836)	2.74495517
79	epithelial cilium movement (GO:0003351)	2.71924088
80	oogenesis (GO:0048477)	2.66840284
81	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.66833452
82	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.65895181
83	tachykinin receptor signaling pathway (GO:0007217)	2.65491678
84	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.65252858
85	heart valve formation (GO:0003188)	2.64903191
86	protein targeting to membrane (GO:0006612)	2.64109519
87	regulation of odontogenesis (GO:0042481)	2.63938510
88	UTP metabolic process (GO:0046051)	2.63317248
89	uterus development (GO:0060065)	2.62131595
90	vitamin transmembrane transport (GO:0035461)	2.61273176
91	reciprocal meiotic recombination (GO:0007131)	2.60113642
92	reciprocal DNA recombination (GO:0035825)	2.60113642
93	sulfur compound transport (GO:0072348)	2.59923678
94	translation (GO:0006412)	2.57090462
95	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.52735487
96	regulation of developmental pigmentation (GO:0048070)	2.51955269
97	nodal signaling pathway (GO:0038092)	2.51767339
98	tryptophan metabolic process (GO:0006568)	2.51757865
99	sphingosine metabolic process (GO:0006670)	11.5358400
100	diol metabolic process (GO:0034311)	10.2063107

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.03292618
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.96583021
3	AR_21572438_ChIP-Seq_LNCaP_Human	2.87863672
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.86462964
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.77548977
6	VDR_22108803_ChIP-Seq_LS180_Human	2.74635017
7	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.55491517
8	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.53806150
9	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.25477937
10	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.18189963
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.14531214
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.07882034
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.02869737
14	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.01984161
15	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.97621151
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.89419460
17	P300_19829295_ChIP-Seq_ESCs_Human	1.86526892
18	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.77141930
19	SOX2_19829295_ChIP-Seq_ESCs_Human	1.73980145
20	NANOG_19829295_ChIP-Seq_ESCs_Human	1.73980145
21	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.70665115
22	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.70442792
23	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.67900481
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62017944
25	HOXB7_26014856_ChIP-Seq_BT474_Human	1.60648813
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.58169605
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.56454866
28	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.51879311
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.49913675
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.45835834
31	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45835834
32	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.42750264
33	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.42381350
34	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.42114810
35	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.40524719
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.38725772
37	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.37754753
38	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.33693475
39	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.32840514
40	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.29161125
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.28389275
42	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.28276501
43	NCOR_22424771_ChIP-Seq_293T_Human	1.28225123
44	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.27582822
45	EWS_26573619_Chip-Seq_HEK293_Human	1.26460392
46	NANOG_20526341_ChIP-Seq_ESCs_Human	1.25440880
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.25338599
48	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.24787992
49	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.22981218
50	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.21449975
51	TAF2_19829295_ChIP-Seq_ESCs_Human	1.19825051
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.19126347
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.19126347
54	OCT4_20526341_ChIP-Seq_ESCs_Human	1.18914698
55	TCF4_23295773_ChIP-Seq_U87_Human	1.17920409
56	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.16782890
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.16537438
58	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.16481125
59	STAT3_23295773_ChIP-Seq_U87_Human	1.15237644
60	EGR1_19032775_ChIP-ChIP_M12_Human	1.14998960
61	P53_21459846_ChIP-Seq_SAOS-2_Human	1.14369880
62	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.12749812
63	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.11999467
64	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.10316622
65	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.10006152
66	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.09520634
67	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.09322383
68	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.08386432
69	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08331779
70	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.07200612
71	CBP_20019798_ChIP-Seq_JUKART_Human	1.07200612
72	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05281871
73	FUS_26573619_Chip-Seq_HEK293_Human	1.02607387
74	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.02382550
75	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.01731453
76	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.01199537
77	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.00871883
78	STAT1_20625510_ChIP-Seq_HELA_Human	1.00720634
79	AR_20517297_ChIP-Seq_VCAP_Human	0.99470611
80	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.99306059
81	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.99277090
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99269277
83	REST_21632747_ChIP-Seq_MESCs_Mouse	0.99176137
84	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.99092772
85	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.97925258
86	TP53_16413492_ChIP-PET_HCT116_Human	0.97232507
87	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.96353736
88	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.96067766
89	MYC_18940864_ChIP-ChIP_HL60_Human	0.95822340
90	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.95718967
91	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.94777431
92	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.93408926
93	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93275776
94	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.92349549
95	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.91233751
96	STAT3_18555785_ChIP-Seq_MESCs_Mouse	0.91204357
97	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.90785777
98	RAC3_21632823_ChIP-Seq_H3396_Human	0.90272586
99	GBX2_23144817_ChIP-Seq_PC3_Human	0.90078276
100	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.90039201

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	7.85280364
2	MP0003136_yellow_coat_color	6.64402134
3	MP0002653_abnormal_ependyma_morphology	6.11954472
4	MP0005171_absent_coat_pigmentation	5.25731249
5	MP0003646_muscle_fatigue	4.33652638
6	MP0002138_abnormal_hepatobiliary_system	3.86103592
7	MP0003890_abnormal_embryonic-extraembry	3.28435697
8	MP0004147_increased_porphyrin_level	3.07873381
9	MP0006292_abnormal_olfactory_placode	2.85707944
10	MP0009379_abnormal_foot_pigmentation	2.75599642
11	MP0003879_abnormal_hair_cell	2.67645830
12	MP0003045_fibrosis	2.65484310
13	MP0000569_abnormal_digit_pigmentation	2.46043578
14	MP0004381_abnormal_hair_follicle	2.17579022
15	MP0002938_white_spotting	2.10947751
16	MP0005075_abnormal_melanosome_morpholog	1.91003233
17	MP0002095_abnormal_skin_pigmentation	1.86826245
18	MP0003787_abnormal_imprinting	1.71562281
19	MP0005085_abnormal_gallbladder_physiolo	1.69764264
20	MP0004233_abnormal_muscle_weight	1.59391103
21	MP0004142_abnormal_muscle_tone	1.54868850
22	MP0008877_abnormal_DNA_methylation	1.45414186
23	MP0003878_abnormal_ear_physiology	1.44495554
24	MP0005377_hearing/vestibular/ear_phenot	1.44495554
25	MP0005670_abnormal_white_adipose	1.39639103
26	MP0005174_abnormal_tail_pigmentation	1.33934253
27	MP0001324_abnormal_eye_pigmentation	1.27934068
28	MP0002160_abnormal_reproductive_system	1.24202075
29	MP0002168_other_aberrant_phenotype	1.18382267
30	MP0002876_abnormal_thyroid_physiology	1.14218162
31	MP0005365_abnormal_bile_salt	1.12244426
32	MP0003195_calcinosis	1.11826983
33	MP0003122_maternal_imprinting	1.09966989
34	MP0005646_abnormal_pituitary_gland	1.08634110
35	MP0002277_abnormal_respiratory_mucosa	1.07984893
36	MP0000427_abnormal_hair_cycle	1.05706237
37	MP0002075_abnormal_coat/hair_pigmentati	1.03115681
38	MP0001529_abnormal_vocalization	1.01637495
39	MP0005551_abnormal_eye_electrophysiolog	0.98809174
40	MP0000778_abnormal_nervous_system	0.97187703
41	MP0000015_abnormal_ear_pigmentation	0.95806149
42	MP0000749_muscle_degeneration	0.93069509
43	MP0001984_abnormal_olfaction	0.91062548
44	MP0003121_genomic_imprinting	0.90303454
45	MP0002163_abnormal_gland_morphology	0.89990385
46	MP0003937_abnormal_limbs/digits/tail_de	0.83208794
47	MP0005389_reproductive_system_phenotype	0.81645933
48	MP0005395_other_phenotype	0.81187686
49	MP0001186_pigmentation_phenotype	0.80421222
50	MP0000026_abnormal_inner_ear	0.78412795
51	MP0008789_abnormal_olfactory_epithelium	0.76179273
52	MP0002272_abnormal_nervous_system	0.75457765
53	MP0006276_abnormal_autonomic_nervous	0.74672939
54	MP0004885_abnormal_endolymph	0.73819960
55	MP0008875_abnormal_xenobiotic_pharmacok	0.73747516
56	MP0001293_anophthalmia	0.72683756
57	MP0009745_abnormal_behavioral_response	0.71986918
58	MP0004130_abnormal_muscle_cell	0.70593254
59	MP0002752_abnormal_somatic_nervous	0.69993233
60	MP0001486_abnormal_startle_reflex	0.67859156
61	MP0001986_abnormal_taste_sensitivity	0.67851993
62	MP0006054_spinal_hemorrhage	0.67002086
63	MP0005195_abnormal_posterior_eye	0.66714347
64	MP0009764_decreased_sensitivity_to	0.65603504
65	MP0008872_abnormal_physiological_respon	0.65067526
66	MP0003186_abnormal_redox_activity	0.64470183
67	MP0008775_abnormal_heart_ventricle	0.62321487
68	MP0002638_abnormal_pupillary_reflex	0.61280068
69	MP0003137_abnormal_impulse_conducting	0.60556455
70	MP0002229_neurodegeneration	0.60328726
71	MP0001963_abnormal_hearing_physiology	0.59027674
72	MP0001764_abnormal_homeostasis	0.57658198
73	MP0000534_abnormal_ureter_morphology	0.56659954
74	MP0002210_abnormal_sex_determination	0.56629299
75	MP0005394_taste/olfaction_phenotype	0.55783076
76	MP0005499_abnormal_olfactory_system	0.55783076
77	MP0001485_abnormal_pinna_reflex	0.53380163
78	MP0001970_abnormal_pain_threshold	0.53301688
79	MP0008569_lethality_at_weaning	0.52831347
80	MP0002735_abnormal_chemical_nociception	0.52468808
81	MP0002102_abnormal_ear_morphology	0.52062150
82	MP0001286_abnormal_eye_development	0.51610137
83	MP0002733_abnormal_thermal_nociception	0.50864813
84	MP0001968_abnormal_touch/_nociception	0.50681705
85	MP0002928_abnormal_bile_duct	0.50435333
86	MP0000470_abnormal_stomach_morphology	0.49521777
87	MP0001440_abnormal_grooming_behavior	0.48568539
88	MP0004043_abnormal_pH_regulation	0.47622948
89	MP0009046_muscle_twitch	0.47060872
90	MP0001501_abnormal_sleep_pattern	0.46378896
91	MP0008770_decreased_survivor_rate	0.44928344
92	MP0003755_abnormal_palate_morphology	0.43124141
93	MP0002882_abnormal_neuron_morphology	0.42760791
94	MP0003718_maternal_effect	0.42403578
95	MP0000049_abnormal_middle_ear	0.41575639
96	MP0003698_abnormal_male_reproductive	0.41442837
97	MP0000372_irregular_coat_pigmentation	0.40728922
98	MP0005410_abnormal_fertilization	0.39210579
99	MP0002572_abnormal_emotion/affect_behav	0.38933390
100	MP0002063_abnormal_learning/memory/cond	0.38595324

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Amelogenesis imperfecta (HP:0000705)	5.87295769
2	Focal motor seizures (HP:0011153)	5.84928118
3	Reticulocytopenia (HP:0001896)	5.34525706
4	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	4.87493257
5	Acanthocytosis (HP:0001927)	4.84548011
6	Parakeratosis (HP:0001036)	4.82964942
7	Pancreatic cysts (HP:0001737)	4.58062217
8	Colon cancer (HP:0003003)	4.07122761
9	Abnormal hemoglobin (HP:0011902)	3.57944381
10	Pancreatic fibrosis (HP:0100732)	3.57419622
11	Abnormality of cells of the erythroid lineage (HP:0012130)	3.53394125
12	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.33847596
13	Abnormality of the renal medulla (HP:0100957)	3.26838894
14	Pallor (HP:0000980)	3.25896486
15	Rectal prolapse (HP:0002035)	3.21204105
16	Nephronophthisis (HP:0000090)	3.20089263
17	Abnormality of midbrain morphology (HP:0002418)	3.13191815
18	Molar tooth sign on MRI (HP:0002419)	3.13191815
19	Aplastic anemia (HP:0001915)	3.12735847
20	Chronic hepatic failure (HP:0100626)	3.11984973
21	Enlarged kidneys (HP:0000105)	3.08218538
22	Macrocytic anemia (HP:0001972)	3.07146878
23	Dialeptic seizures (HP:0011146)	2.90556994
24	Cystic liver disease (HP:0006706)	2.90238387
25	Type II lissencephaly (HP:0007260)	2.89468184
26	Poikilocytosis (HP:0004447)	2.84168666
27	Abnormality of the renal cortex (HP:0011035)	2.83985313
28	Erythroderma (HP:0001019)	2.80822301
29	Pendular nystagmus (HP:0012043)	2.70739447
30	True hermaphroditism (HP:0010459)	2.68723011
31	Congenital ichthyosiform erythroderma (HP:0007431)	2.68279819
32	Tubular atrophy (HP:0000092)	2.61120278
33	Congenital stationary night blindness (HP:0007642)	2.57807987
34	Anencephaly (HP:0002323)	2.48254217
35	Nonprogressive disorder (HP:0003680)	2.45773098
36	Cerebellar dysplasia (HP:0007033)	2.44158930
37	Acute necrotizing encephalopathy (HP:0006965)	2.42601003
38	Proximal amyotrophy (HP:0007126)	2.42579884
39	11 pairs of ribs (HP:0000878)	2.38211409
40	Focal seizures (HP:0007359)	2.34742701
41	Abnormal mitochondria in muscle tissue (HP:0008316)	2.28620540
42	Abnormal number of erythroid precursors (HP:0012131)	2.26653627
43	Tubulointerstitial fibrosis (HP:0005576)	2.23534860
44	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.23472863
45	Acute encephalopathy (HP:0006846)	2.23233235
46	Abnormality of DNA repair (HP:0003254)	2.17365927
47	Hyperglycinuria (HP:0003108)	2.17251283
48	Hyperthyroidism (HP:0000836)	2.17004100
49	Congenital hepatic fibrosis (HP:0002612)	2.16185018
50	Radial bowing (HP:0002986)	2.15436235
51	Potter facies (HP:0002009)	2.10712722
52	Facial shape deformation (HP:0011334)	2.10712722
53	Stenosis of the external auditory canal (HP:0000402)	2.10458463
54	3-Methylglutaconic aciduria (HP:0003535)	2.10381657
55	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.10116533
56	Hypoplastic iliac wings (HP:0002866)	2.08752848
57	Portal hypertension (HP:0001409)	2.06778431
58	Hyperglycinemia (HP:0002154)	2.02563563
59	Synostosis of carpal bones (HP:0005048)	2.00376184
60	Septo-optic dysplasia (HP:0100842)	1.99064294
61	Oligodactyly (hands) (HP:0001180)	1.96984572
62	Hematochezia (HP:0002573)	1.95702571
63	Colitis (HP:0002583)	1.93666672
64	Sclerocornea (HP:0000647)	1.92465715
65	Depressed nasal ridge (HP:0000457)	1.91187927
66	Panhypogammaglobulinemia (HP:0003139)	1.90994212
67	Ulnar claw (HP:0001178)	1.90455261
68	Scapular winging (HP:0003691)	1.89546968
69	Abnormality of the hepatic vasculature (HP:0006707)	1.87820171
70	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.86771119
71	Abnormality of macular pigmentation (HP:0008002)	1.83767004
72	Birth length less than 3rd percentile (HP:0003561)	1.83616774
73	Ectopic kidney (HP:0000086)	1.82442934
74	Retinitis pigmentosa (HP:0000510)	1.82275941
75	Absent thumb (HP:0009777)	1.81742229
76	Progressive macrocephaly (HP:0004481)	1.75788222
77	Increased CSF lactate (HP:0002490)	1.75250258
78	Postaxial foot polydactyly (HP:0001830)	1.73037195
79	Chromsome breakage (HP:0040012)	1.70864721
80	Polydipsia (HP:0001959)	1.70036817
81	Abnormal drinking behavior (HP:0030082)	1.70036817
82	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.69866622
83	Spontaneous hematomas (HP:0007420)	1.68791756
84	Thyroid-stimulating hormone excess (HP:0002925)	1.68108083
85	Hypomagnesemia (HP:0002917)	1.67802871
86	Mitochondrial inheritance (HP:0001427)	1.66737905
87	Medial flaring of the eyebrow (HP:0010747)	1.66194035
88	Hypoplasia of the brainstem (HP:0002365)	1.65427471
89	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.65427471
90	Abnormality of reticulocytes (HP:0004312)	1.65307843
91	Pancytopenia (HP:0001876)	1.64855314
92	Abnormality of magnesium homeostasis (HP:0004921)	1.64801312
93	Albinism (HP:0001022)	1.64645489
94	Lissencephaly (HP:0001339)	1.64537792
95	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.63209203
96	Cerebral edema (HP:0002181)	1.62440552
97	Genetic anticipation (HP:0003743)	1.61752860
98	Overlapping toe (HP:0001845)	1.61592752
99	Volvulus (HP:0002580)	1.59465210
100	Tubulointerstitial abnormality (HP:0001969)	1.58952227

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	8.57482783
2	STK38L	5.44030401
3	LATS2	4.94013131
4	BMPR1B	4.85478871
5	ZAK	3.29244964
6	PRKD3	2.88047967
7	TGFBR1	2.74740205
8	BCKDK	2.50347014
9	FRK	2.49594368
10	STK3	2.01082888
11	NLK	1.96757647
12	PINK1	1.95811460
13	MAP2K2	1.91970146
14	ACVR1B	1.89626204
15	CDK8	1.87316502
16	STK16	1.79091795
17	WNK4	1.76093203
18	MELK	1.57614163
19	STK38	1.55565083
20	ADRBK2	1.43407204
21	GRK1	1.40288717
22	NEK2	1.03262543
23	TIE1	0.95630771
24	PIK3CA	0.95314172
25	LRRK2	0.86631024
26	KIT	0.86378667
27	PIK3CG	0.86193902
28	TRIM28	0.82668968
29	PRKAA2	0.72538013
30	MAP4K2	0.65698608
31	PDPK1	0.65438392
32	TAF1	0.63750776
33	STK39	0.63687015
34	ADRBK1	0.62267438
35	EIF2AK3	0.61463626
36	CDK19	0.58014102
37	CHEK2	0.57483050
38	DYRK2	0.57451954
39	GRK7	0.57307623
40	PLK2	0.55180558
41	MAP3K2	0.54755406
42	EPHB2	0.54421387
43	STK11	0.53658699
44	PIM1	0.48892149
45	CDC7	0.48602613
46	PRKCG	0.48182460
47	TAOK3	0.46664308
48	NEK1	0.46321865
49	MET	0.44922725
50	PRKCH	0.44678991
51	PRKCI	0.43791549
52	KSR2	0.42080348
53	WNK1	0.41569745
54	ABL2	0.41409540
55	MKNK2	0.40444700
56	PBK	0.40353534
57	MAP3K11	0.40344936
58	PLK3	0.37729468
59	DAPK2	0.37481965
60	CSNK1A1L	0.37429686
61	OXSR1	0.36841998
62	PLK1	0.36336921
63	TXK	0.36281857
64	TEC	0.35900182
65	MOS	0.35715579
66	EPHA4	0.34528102
67	TNK2	0.33730346
68	GRK5	0.32995824
69	NUAK1	0.30913131
70	TGFBR2	0.26855526
71	PRKACA	0.26598050
72	MAPK13	0.25892153
73	PRKCZ	0.24818668
74	DAPK3	0.24714521
75	AURKB	0.23688268
76	PRKCE	0.23244719
77	PRKD1	0.22683385
78	CAMK1	0.22636964
79	INSRR	0.22547245
80	PDK2	0.21847300
81	PRKCQ	0.21566415
82	BTK	0.20571124
83	TTK	0.18071004
84	ATR	0.17171909
85	CSNK1A1	0.16904849
86	MAPK3	0.16690202
87	RPS6KA6	0.16258119
88	CSNK1D	0.16160650
89	CDK9	0.15261336
90	PRKACB	0.14524990
91	AKT1	0.14467840
92	NTRK2	0.14457964
93	AURKA	0.14224693
94	FLT3	0.14195183
95	CSNK2A2	0.13802239
96	ABL1	0.13486555
97	SYK	0.13347879
98	PASK	0.12768477
99	MAP2K1	0.12469369
100	ATM	0.11714811

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	5.25615453
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.86834241
3	Ribosome_Homo sapiens_hsa03010	4.74163055
4	Phototransduction_Homo sapiens_hsa04744	4.02664736
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.43570079
6	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.00514392
7	Basal transcription factors_Homo sapiens_hsa03022	2.74113199
8	Nicotine addiction_Homo sapiens_hsa05033	2.70646758
9	Sphingolipid metabolism_Homo sapiens_hsa00600	2.31228098
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.06112444
11	One carbon pool by folate_Homo sapiens_hsa00670	2.05026609
12	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.78983900
13	Taste transduction_Homo sapiens_hsa04742	1.71983890
14	Morphine addiction_Homo sapiens_hsa05032	1.64842340
15	Parkinsons disease_Homo sapiens_hsa05012	1.55926391
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.55191830
17	Sulfur relay system_Homo sapiens_hsa04122	1.53611016
18	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.46318524
19	Huntingtons disease_Homo sapiens_hsa05016	1.45401891
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.45013115
21	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.33620231
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.32518469
23	Asthma_Homo sapiens_hsa05310	1.29884005
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.25461751
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.20247539
26	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.17129916
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.15788923
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.15278944
29	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.11969380
30	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.06261313
31	Phenylalanine metabolism_Homo sapiens_hsa00360	1.05743220
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.04618318
33	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.04272955
34	GABAergic synapse_Homo sapiens_hsa04727	1.01624697
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.98237202
36	Alzheimers disease_Homo sapiens_hsa05010	0.95582999
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.91260165
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.87062463
39	Butanoate metabolism_Homo sapiens_hsa00650	0.86422178
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86107673
41	RNA degradation_Homo sapiens_hsa03018	0.85976885
42	Homologous recombination_Homo sapiens_hsa03440	0.82799011
43	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.81671323
44	Glutamatergic synapse_Homo sapiens_hsa04724	0.78931253
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78099078
46	Olfactory transduction_Homo sapiens_hsa04740	0.77431533
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.75637928
48	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.74131909
49	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.74041977
50	Basal cell carcinoma_Homo sapiens_hsa05217	0.71254832
51	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.70149914
52	VEGF signaling pathway_Homo sapiens_hsa04370	0.67696832
53	Hippo signaling pathway_Homo sapiens_hsa04390	0.66163956
54	Calcium signaling pathway_Homo sapiens_hsa04020	0.65020165
55	Bile secretion_Homo sapiens_hsa04976	0.62795667
56	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.62275239
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.61211514
58	Serotonergic synapse_Homo sapiens_hsa04726	0.59374465
59	Fatty acid degradation_Homo sapiens_hsa00071	0.57760920
60	Allograft rejection_Homo sapiens_hsa05330	0.56586767
61	RNA polymerase_Homo sapiens_hsa03020	0.55909422
62	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.54637190
63	Viral myocarditis_Homo sapiens_hsa05416	0.53378066
64	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.52056288
65	Metabolic pathways_Homo sapiens_hsa01100	0.51144497
66	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.49099392
67	Primary immunodeficiency_Homo sapiens_hsa05340	0.40310835
68	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.40125625
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.38315890
70	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.38295916
71	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.37925059
72	Glycerolipid metabolism_Homo sapiens_hsa00561	0.37777885
73	Insulin secretion_Homo sapiens_hsa04911	0.36441373
74	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.36055866
75	Tyrosine metabolism_Homo sapiens_hsa00350	0.35765507
76	Lysine degradation_Homo sapiens_hsa00310	0.35491454
77	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.34873718
78	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.33475117
79	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.32618762
80	Retinol metabolism_Homo sapiens_hsa00830	0.32098981
81	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.30778857
82	Salivary secretion_Homo sapiens_hsa04970	0.30163838
83	Pyrimidine metabolism_Homo sapiens_hsa00240	0.30074584
84	cAMP signaling pathway_Homo sapiens_hsa04024	0.29260271
85	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.28696422
86	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.28668521
87	Purine metabolism_Homo sapiens_hsa00230	0.28286900
88	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.26195000
89	Caffeine metabolism_Homo sapiens_hsa00232	0.23232786
90	Collecting duct acid secretion_Homo sapiens_hsa04966	0.21297039
91	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.20848158
92	Fat digestion and absorption_Homo sapiens_hsa04975	0.20587442
93	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.20346451
94	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.18879593
95	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.18625737
96	Folate biosynthesis_Homo sapiens_hsa00790	0.18533920
97	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.17117539
98	African trypanosomiasis_Homo sapiens_hsa05143	0.16680972
99	Graft-versus-host disease_Homo sapiens_hsa05332	0.15800686
100	Histidine metabolism_Homo sapiens_hsa00340	0.14179741

RPS20P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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