RPS21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S21E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants that encode different protein isoforms have been described, but their existence has not been verified. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* translational initiation (GO:0006413)9.18396378
2maturation of SSU-rRNA (GO:0030490)9.04753770
3* protein complex disassembly (GO:0043241)8.93153857
4ribosomal large subunit biogenesis (GO:0042273)8.44623679
5* macromolecular complex disassembly (GO:0032984)8.30167651
6* protein targeting to membrane (GO:0006612)7.45972376
7* nuclear-transcribed mRNA catabolic process (GO:0000956)6.66629932
8* mRNA catabolic process (GO:0006402)6.30102376
9* translation (GO:0006412)6.29489596
10* RNA catabolic process (GO:0006401)5.72001745
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.63843715
12energy coupled proton transport, down electrochemical gradient (GO:0015985)5.46835674
13ATP synthesis coupled proton transport (GO:0015986)5.46835674
14* ribonucleoprotein complex biogenesis (GO:0022613)5.38654260
15* establishment of protein localization to membrane (GO:0090150)5.12655329
16deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.05792927
17* protein targeting (GO:0006605)4.58771403
18* establishment of protein localization to organelle (GO:0072594)4.39406179
19regulation of mitochondrial translation (GO:0070129)4.21082045
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.08051250
21* cellular component biogenesis (GO:0044085)4.02212520
22* protein localization to membrane (GO:0072657)3.96516389
23* rRNA processing (GO:0006364)3.95259268
24protein complex biogenesis (GO:0070271)3.93684969
25pseudouridine synthesis (GO:0001522)3.90114984
26ribosome biogenesis (GO:0042254)3.88583777
27mitochondrial respiratory chain complex assembly (GO:0033108)3.88048033
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.84884409
29NADH dehydrogenase complex assembly (GO:0010257)3.84884409
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.84884409
31* rRNA metabolic process (GO:0016072)3.80029121
32respiratory electron transport chain (GO:0022904)3.73877351
33pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.72780319
34protein neddylation (GO:0045116)3.67389440
35electron transport chain (GO:0022900)3.65119367
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.60131057
37* cellular component disassembly (GO:0022411)3.50344565
38ncRNA 3-end processing (GO:0043628)3.40495618
39rRNA modification (GO:0000154)3.38790595
40formation of translation preinitiation complex (GO:0001731)3.34542269
41GTP biosynthetic process (GO:0006183)3.27115096
42UTP biosynthetic process (GO:0006228)3.26638120
43* protein localization to organelle (GO:0033365)3.17380939
44spliceosomal complex assembly (GO:0000245)3.12433191
45pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.03442684
46pyrimidine nucleotide catabolic process (GO:0006244)3.02463187
47DNA deamination (GO:0045006)2.98159188
48mitochondrial transport (GO:0006839)2.97278401
49intracellular protein transmembrane import (GO:0044743)2.90839419
50spliceosomal snRNP assembly (GO:0000387)2.90624324
51protein-cofactor linkage (GO:0018065)2.89884756
52nucleoside triphosphate biosynthetic process (GO:0009142)2.87123228
53base-excision repair, AP site formation (GO:0006285)2.81821380
54termination of RNA polymerase III transcription (GO:0006386)2.80349968
55transcription elongation from RNA polymerase III promoter (GO:0006385)2.80349968
56UTP metabolic process (GO:0046051)2.78479232
57establishment of integrated proviral latency (GO:0075713)2.73244877
58DNA replication checkpoint (GO:0000076)2.69695276
59transcription from mitochondrial promoter (GO:0006390)2.68213029
60* gene expression (GO:0010467)2.64741296
61rRNA methylation (GO:0031167)2.62612616
62purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.62510013
63water-soluble vitamin biosynthetic process (GO:0042364)2.61234052
64antibacterial humoral response (GO:0019731)2.58024918
65nucleoside salvage (GO:0043174)2.57575783
66purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.55458698
67purine nucleoside monophosphate biosynthetic process (GO:0009127)2.55458698
68nucleoside monophosphate biosynthetic process (GO:0009124)2.52974112
69NADH metabolic process (GO:0006734)2.51251204
70negative regulation of RNA splicing (GO:0033119)2.51221950
71purine nucleoside triphosphate biosynthetic process (GO:0009145)2.50849762
72GMP metabolic process (GO:0046037)2.48198126
73deoxyribose phosphate biosynthetic process (GO:0046385)2.46558077
742-deoxyribonucleotide biosynthetic process (GO:0009265)2.46558077
75negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.46185536
76pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.45724283
77regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.45347174
78nucleobase-containing small molecule interconversion (GO:0015949)2.44626648
79ribonucleoside triphosphate biosynthetic process (GO:0009201)2.44553278
80ATP biosynthetic process (GO:0006754)2.44051418
81antimicrobial humoral response (GO:0019730)2.44014069
82CTP metabolic process (GO:0046036)2.40285420
83CTP biosynthetic process (GO:0006241)2.40285420
84chaperone-mediated protein transport (GO:0072321)2.33651034
85establishment of viral latency (GO:0019043)2.32580311
86ribonucleoprotein complex assembly (GO:0022618)2.31173125
87* ncRNA processing (GO:0034470)2.29069897
88DNA damage response, detection of DNA damage (GO:0042769)2.28549783
89guanosine-containing compound biosynthetic process (GO:1901070)2.21867583
90* single-organism cellular localization (GO:1902580)2.21701757
91regulation of protein heterodimerization activity (GO:0043497)2.21689307
92myeloid cell homeostasis (GO:0002262)2.17668767
93ribonucleoprotein complex subunit organization (GO:0071826)2.16580759
94pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.16357109
95termination of RNA polymerase I transcription (GO:0006363)2.15172858
96pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.14662231
97establishment of protein localization to mitochondrion (GO:0072655)2.14244320
98negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.12798313
99middle ear morphogenesis (GO:0042474)2.11863150
100proteasome assembly (GO:0043248)2.10052585
101exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.09876678
102regulation of gene silencing by RNA (GO:0060966)2.08950203
103regulation of posttranscriptional gene silencing (GO:0060147)2.08950203
104regulation of gene silencing by miRNA (GO:0060964)2.08950203
105hydrogen ion transmembrane transport (GO:1902600)2.07760321
106nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.07596204
107transcription elongation from RNA polymerase I promoter (GO:0006362)2.07078855
108protein targeting to mitochondrion (GO:0006626)2.06513114
109termination of RNA polymerase II transcription (GO:0006369)2.05428463
110pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.05363536
111* ncRNA metabolic process (GO:0034660)2.05338797
112innate immune response in mucosa (GO:0002227)2.03658954
113transcription from RNA polymerase I promoter (GO:0006360)2.00461623
114DNA-templated transcription, termination (GO:0006353)2.00434733
115* viral transcription (GO:0019083)13.8993878
116* translational termination (GO:0006415)13.2647410
117* ribosomal small subunit biogenesis (GO:0042274)11.9847407
118ribosomal small subunit assembly (GO:0000028)11.4438911
119* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)11.0641076
120* translational elongation (GO:0006414)11.0104324
121* protein targeting to ER (GO:0045047)10.9743635
122* cotranslational protein targeting to membrane (GO:0006613)10.9246992
123* establishment of protein localization to endoplasmic reticulum (GO:0072599)10.5246648
124* cellular protein complex disassembly (GO:0043624)10.3391520
125* viral life cycle (GO:0019058)10.2608089
126* protein localization to endoplasmic reticulum (GO:0070972)10.2303242
127* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)10.0443110
128positive regulation of gastrulation (GO:2000543)1.99855419
129keratinocyte development (GO:0003334)1.97935699
130positive regulation of transcription regulatory region DNA binding (GO:2000679)1.97329841
131protein localization to mitochondrion (GO:0070585)1.95526893
132RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)1.95015573
133mRNA splicing, via spliceosome (GO:0000398)1.95015573

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.65068628
2* MYC_18555785_ChIP-Seq_MESCs_Mouse5.08722680
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.40417786
4* MYC_19079543_ChIP-ChIP_MESCs_Mouse4.26414652
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.02289285
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.70068865
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.28383782
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.18230518
9* XRN2_22483619_ChIP-Seq_HELA_Human3.10111061
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.10104632
11E2F7_22180533_ChIP-Seq_HELA_Human2.99518132
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.98086143
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.82502020
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72304477
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.64687801
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61539959
17* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59937471
18TTF2_22483619_ChIP-Seq_HELA_Human2.59188704
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.47092981
20* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42211214
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.23819847
22KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.13604843
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.11749714
24* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11098979
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.09201806
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.09201806
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.09201806
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07128701
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.06773910
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06634173
31DCP1A_22483619_ChIP-Seq_HELA_Human2.00956734
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.96822662
33* VDR_23849224_ChIP-Seq_CD4+_Human1.93915247
34CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.93489542
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93200070
36ELK1_19687146_ChIP-ChIP_HELA_Human1.92816446
37ELK1_22589737_ChIP-Seq_MCF10A_Human1.84762577
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80323186
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.75492689
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71174652
41* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67642573
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.66952592
43* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66280082
44* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65956578
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63835537
46KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.63793325
47TCF3_18692474_ChIP-Seq_MEFs_Mouse1.55833916
48FOXP3_21729870_ChIP-Seq_TREG_Human1.55605332
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.50102067
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48579332
51* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46009199
52* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.45453164
53MYC_18940864_ChIP-ChIP_HL60_Human1.44998194
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.42015330
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.40726326
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.40636971
57VDR_21846776_ChIP-Seq_THP-1_Human1.39376747
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38857819
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37111479
60ZNF263_19887448_ChIP-Seq_K562_Human1.36452767
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.35529647
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34825304
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33990916
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.33300253
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28967778
66* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28358090
67* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.27611164
68HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.26336343
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.21682049
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.19687991
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19020175
72* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18679022
73CTCF_26484167_Chip-Seq_Bcells_Mouse1.17902138
74* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17821705
75SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17452890
76ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16445839
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.13762614
78SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12475545
79* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12467705
80* LXR_22292898_ChIP-Seq_THP-1_Human1.11654183
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10653622
82* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09114566
83* GABP_19822575_ChIP-Seq_HepG2_Human1.08674522
84CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08511488
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07517676
86P68_20966046_ChIP-Seq_HELA_Human1.07215079
87* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.05312998
88SOX2_16153702_ChIP-ChIP_HESCs_Human1.04655663
89CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01568999
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00762425
91* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00254057
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97945831
93BCL6_27268052_Chip-Seq_Bcells_Human0.97567426
94* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97369075
95* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96271885
96* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95807204
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95630600
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95483459
99IRF1_19129219_ChIP-ChIP_H3396_Human0.95150384
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94403153
101TRIM28_21343339_ChIP-Seq_HEK293_Human0.94300613
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93566508
103SA1_27219007_Chip-Seq_ERYTHROID_Human0.93430382
104EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.93047890
105* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93042278
106* MAF_26560356_Chip-Seq_TH2_Human0.92487237
107SA1_27219007_Chip-Seq_Bcells_Human0.92289565
108POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91304634
109PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91209916
110* FOXP1_21924763_ChIP-Seq_HESCs_Human0.91062967
111CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90595308
112RACK7_27058665_Chip-Seq_MCF-7_Human0.89222358
113KDM5A_27292631_Chip-Seq_BREAST_Human0.88572421
114STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.86950456
115MYC_22102868_ChIP-Seq_BL_Human0.86094312
116ELF1_20517297_ChIP-Seq_JURKAT_Human0.85739180
117YY1_22570637_ChIP-Seq_MALME-3M_Human0.85194866
118CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85138455
119KLF4_18555785_ChIP-Seq_MESCs_Mouse0.84664194
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83860478
121TCF3_18692474_ChIP-Seq_MESCs_Mouse0.81839831
122* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.81210757
123STAT1_20625510_ChIP-Seq_HELA_Human0.81102986
124ELF5_23300383_ChIP-Seq_T47D_Human0.80978253
125* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80058757
126* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79718193
127ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.77998490
128* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.77372652
129* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.77093990
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.76338873
131* ELK3_25401928_ChIP-Seq_HUVEC_Human0.75907593

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.92638010
2MP0006292_abnormal_olfactory_placode4.34118318
3MP0003136_yellow_coat_color3.91238333
4MP0004957_abnormal_blastocyst_morpholog2.81801140
5MP0004381_abnormal_hair_follicle2.76289929
6MP0001873_stomach_inflammation2.67669563
7MP0003693_abnormal_embryo_hatching2.59334759
8MP0002796_impaired_skin_barrier2.56760673
9MP0003806_abnormal_nucleotide_metabolis2.56372926
10MP0003879_abnormal_hair_cell2.51361312
11MP0004510_myositis2.51042468
12MP0003941_abnormal_skin_development2.44650109
13MP0000678_abnormal_parathyroid_gland2.30401274
14MP0003186_abnormal_redox_activity2.27286713
15MP0010030_abnormal_orbit_morphology2.17794726
16MP0008932_abnormal_embryonic_tissue2.01693630
17MP0000762_abnormal_tongue_morphology2.01123860
18MP0004858_abnormal_nervous_system1.99999668
19MP0003315_abnormal_perineum_morphology1.98720992
20MP0002160_abnormal_reproductive_system1.96141955
21MP0010234_abnormal_vibrissa_follicle1.85825617
22MP0005501_abnormal_skin_physiology1.82321303
23MP0000049_abnormal_middle_ear1.66764123
24MP0006036_abnormal_mitochondrial_physio1.65723138
25MP0002282_abnormal_trachea_morphology1.63687071
26MP0003938_abnormal_ear_development1.61522815
27MP0002277_abnormal_respiratory_mucosa1.57416875
28MP0002132_abnormal_respiratory_system1.56204114
29MP0003077_abnormal_cell_cycle1.52976092
30MP0000537_abnormal_urethra_morphology1.51926306
31MP0001905_abnormal_dopamine_level1.51916681
32MP0005377_hearing/vestibular/ear_phenot1.48560718
33MP0003878_abnormal_ear_physiology1.48560718
34MP0009053_abnormal_anal_canal1.46544934
35MP0008058_abnormal_DNA_repair1.46253483
36MP0002938_white_spotting1.46049737
37MP0002102_abnormal_ear_morphology1.44822142
38MP0003453_abnormal_keratinocyte_physiol1.44582598
39MP0005499_abnormal_olfactory_system1.44274491
40MP0005394_taste/olfaction_phenotype1.44274491
41MP0002249_abnormal_larynx_morphology1.40269432
42MP0003121_genomic_imprinting1.39574131
43MP0002095_abnormal_skin_pigmentation1.38227196
44MP0005379_endocrine/exocrine_gland_phen1.38029049
45MP0000750_abnormal_muscle_regeneration1.37804290
46MP0005646_abnormal_pituitary_gland1.33569707
47MP0000372_irregular_coat_pigmentation1.29935510
48MP0006072_abnormal_retinal_apoptosis1.28171868
49MP0005389_reproductive_system_phenotype1.26551880
50MP0006082_CNS_inflammation1.26310567
51MP0003283_abnormal_digestive_organ1.26043551
52MP0009250_abnormal_appendicular_skeleto1.24507256
53MP0008875_abnormal_xenobiotic_pharmacok1.24399263
54MP0000467_abnormal_esophagus_morphology1.24257125
55MP0001216_abnormal_epidermal_layer1.23673344
56MP0002638_abnormal_pupillary_reflex1.22951315
57MP0003123_paternal_imprinting1.22515558
58MP0003937_abnormal_limbs/digits/tail_de1.21226963
59MP0003786_premature_aging1.19820224
60MP0002234_abnormal_pharynx_morphology1.19766466
61MP0001727_abnormal_embryo_implantation1.18970717
62MP0004145_abnormal_muscle_electrophysio1.18732262
63MP0003111_abnormal_nucleus_morphology1.18139864
64MP0001881_abnormal_mammary_gland1.17684730
65MP0000613_abnormal_salivary_gland1.16212173
66MP0001663_abnormal_digestive_system1.16166981
67MP0001346_abnormal_lacrimal_gland1.16057118
68MP0002060_abnormal_skin_morphology1.15453144
69MP0009333_abnormal_splenocyte_physiolog1.15225656
70MP0002751_abnormal_autonomic_nervous1.15219119
71MP0010771_integument_phenotype1.14970915
72MP0008789_abnormal_olfactory_epithelium1.13776054
73MP0002163_abnormal_gland_morphology1.10766780
74MP0008995_early_reproductive_senescence1.09428817
75MP0003755_abnormal_palate_morphology1.07734560
76MP0003718_maternal_effect1.07180919
77MP0001340_abnormal_eyelid_morphology1.07133715
78MP0001919_abnormal_reproductive_system1.05168888
79MP0002932_abnormal_joint_morphology1.05158890
80MP0004185_abnormal_adipocyte_glucose1.04738284
81MP0002111_abnormal_tail_morphology1.04372385
82MP0000383_abnormal_hair_follicle1.03473669
83MP0005275_abnormal_skin_tensile1.03337633
84MP0005084_abnormal_gallbladder_morpholo1.03067593
85MP0002210_abnormal_sex_determination1.02342049
86MP0000490_abnormal_crypts_of1.01930583
87MP0010094_abnormal_chromosome_stability1.01649782
88MP0002098_abnormal_vibrissa_morphology1.00623590
89MP0000350_abnormal_cell_proliferation0.99923139
90MP0002876_abnormal_thyroid_physiology0.99540447
91MP0000462_abnormal_digestive_system0.98785424
92MP0003011_delayed_dark_adaptation0.98227775
93MP0001286_abnormal_eye_development0.96056750
94MP0010678_abnormal_skin_adnexa0.94616436
95MP0003385_abnormal_body_wall0.93481956
96MP0005408_hypopigmentation0.93403393
97MP0004272_abnormal_basement_membrane0.92622568
98MP0002085_abnormal_embryonic_tissue0.91667302
99MP0005409_darkened_coat_color0.91560637
100MP0001730_embryonic_growth_arrest0.90586250
101MP0004133_heterotaxia0.90407087
102MP0005174_abnormal_tail_pigmentation0.89478124
103MP0005023_abnormal_wound_healing0.87826390
104MP0002177_abnormal_outer_ear0.85770186
105MP0003567_abnormal_fetal_cardiomyocyte0.85339900
106MP0000377_abnormal_hair_follicle0.84881830
107MP0001529_abnormal_vocalization0.84804921
108MP0001270_distended_abdomen0.84713288
109MP0000015_abnormal_ear_pigmentation0.84387803
110MP0002697_abnormal_eye_size0.81689173
111MP0001348_abnormal_lacrimal_gland0.80651999
112MP0002233_abnormal_nose_morphology0.79944335
113MP0005623_abnormal_meninges_morphology0.79874967
114MP0000631_abnormal_neuroendocrine_gland0.79001289
115MP0000703_abnormal_thymus_morphology0.78793575
116MP0000313_abnormal_cell_death0.78128872
117MP0005451_abnormal_body_composition0.78125546
118MP0000858_altered_metastatic_potential0.77454472
119MP0003119_abnormal_digestive_system0.76875296
120MP0004142_abnormal_muscle_tone0.75689362
121MP0000647_abnormal_sebaceous_gland0.75417081
122MP0009931_abnormal_skin_appearance0.74996144
123MP0002084_abnormal_developmental_patter0.73993224
124MP0005076_abnormal_cell_differentiation0.73821217
125MP0010352_gastrointestinal_tract_polyps0.72329652
126MP0002116_abnormal_craniofacial_bone0.72085899
127MP0005508_abnormal_skeleton_morphology0.71792928
128MP0003763_abnormal_thymus_physiology0.71339910
129MP0008057_abnormal_DNA_replication0.71298672
130MP0000566_synostosis0.70316091
131MP0000681_abnormal_thyroid_gland0.70268271
132MP0003942_abnormal_urinary_system0.70205250
133MP0005075_abnormal_melanosome_morpholog0.69232607
134MP0000470_abnormal_stomach_morphology0.68464098
135MP0001293_anophthalmia0.68385075
136MP0008438_abnormal_cutaneous_collagen0.68015960
137MP0002837_dystrophic_cardiac_calcinosis0.67626524
138MP0005381_digestive/alimentary_phenotyp0.67466508
139MP0002080_prenatal_lethality0.67401090
140MP0001145_abnormal_male_reproductive0.67020935
141MP0004197_abnormal_fetal_growth/weight/0.66896626
142MP0001853_heart_inflammation0.66888265
143MP0000477_abnormal_intestine_morphology0.65992366
144MP0000026_abnormal_inner_ear0.65306237
145MP0006035_abnormal_mitochondrial_morpho0.63160752
146MP0003936_abnormal_reproductive_system0.60101950
147MP0000653_abnormal_sex_gland0.58379696
148MP0001851_eye_inflammation0.56635414
149MP0004019_abnormal_vitamin_homeostasis0.56272263
150MP0001485_abnormal_pinna_reflex0.54497323
151MP0002928_abnormal_bile_duct0.52705631
152MP0005195_abnormal_posterior_eye0.52103910

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)9.34302707
2Reticulocytopenia (HP:0001896)9.25429815
3Macrocytic anemia (HP:0001972)7.62453182
4Pallor (HP:0000980)6.74843962
5Abnormal hemoglobin (HP:0011902)4.62528995
6Aplasia/Hypoplasia of the sacrum (HP:0008517)3.85210321
7Increased hepatocellular lipid droplets (HP:0006565)3.82096408
8Concave nail (HP:0001598)3.81587960
9Acute necrotizing encephalopathy (HP:0006965)3.77103070
10Metaphyseal cupping (HP:0003021)3.68747587
11Stenosis of the external auditory canal (HP:0000402)3.63997572
12Hyperthyroidism (HP:0000836)3.43378548
13Mitochondrial inheritance (HP:0001427)3.33640602
14Fragile nails (HP:0001808)3.32945926
15Hepatic necrosis (HP:0002605)3.21088420
16Abnormal mitochondria in muscle tissue (HP:0008316)3.20024170
17Woolly hair (HP:0002224)3.19509879
18Progressive macrocephaly (HP:0004481)3.15819073
19Lipid accumulation in hepatocytes (HP:0006561)3.14253038
20Depressed nasal ridge (HP:0000457)3.14207084
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.13370493
22Abnormality of reticulocytes (HP:0004312)3.05704984
23Renal Fanconi syndrome (HP:0001994)2.99979640
24Constricted visual fields (HP:0001133)2.98610761
25Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.94567376
26Cupped ribs (HP:0000887)2.93418869
27Trismus (HP:0000211)2.88824042
28Partial duplication of the phalanx of hand (HP:0009999)2.86280045
29Lactic acidosis (HP:0003128)2.83866201
30Acute encephalopathy (HP:0006846)2.79245134
31Exertional dyspnea (HP:0002875)2.76378048
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.74378932
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.74378932
34Congenital, generalized hypertrichosis (HP:0004540)2.72622225
35Migraine (HP:0002076)2.71547640
36Absent thumb (HP:0009777)2.70975554
37Partial duplication of thumb phalanx (HP:0009944)2.69507880
38Abnormality of macular pigmentation (HP:0008002)2.67036525
39Increased serum lactate (HP:0002151)2.63757735
40Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.62826692
41Abnormality of secondary sexual hair (HP:0009888)2.56820249
42Abnormality of the axillary hair (HP:0100134)2.56820249
43Aplastic anemia (HP:0001915)2.56330236
44Increased intramyocellular lipid droplets (HP:0012240)2.55033390
45Breast hypoplasia (HP:0003187)2.55030122
46Increased CSF lactate (HP:0002490)2.55002028
47Hypoplasia of the radius (HP:0002984)2.54675055
48Asplenia (HP:0001746)2.54140710
49Thick lower lip vermilion (HP:0000179)2.52568825
50Multiple enchondromatosis (HP:0005701)2.50258543
51Congenital ichthyosiform erythroderma (HP:0007431)2.43009202
52Parakeratosis (HP:0001036)2.42903585
53Respiratory difficulties (HP:0002880)2.35521708
54Sensory axonal neuropathy (HP:0003390)2.34868176
55Aplasia/Hypoplasia of the spleen (HP:0010451)2.33697554
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.31633498
57Sparse lateral eyebrow (HP:0005338)2.29189460
58Oligodontia (HP:0000677)2.24461403
59Triphalangeal thumb (HP:0001199)2.22144372
60Round ear (HP:0100830)2.18674397
61Progressive muscle weakness (HP:0003323)2.18236041
62Ridged nail (HP:0001807)2.15483641
63Lethargy (HP:0001254)2.14450158
64Colon cancer (HP:0003003)2.13577050
65Hepatocellular necrosis (HP:0001404)2.13542713
6611 pairs of ribs (HP:0000878)2.13526540
67Aplasia cutis congenita (HP:0001057)2.09642796
68Myokymia (HP:0002411)2.08901921
69Thrombocytosis (HP:0001894)2.08207714
70Truncus arteriosus (HP:0001660)2.08140591
71Sparse eyelashes (HP:0000653)2.06106371
72Hyperglycinemia (HP:0002154)2.05422621
73Hypoplasia of the ulna (HP:0003022)2.03530091
74Chin dimple (HP:0010751)2.00112233
75Abnormality of cells of the erythroid lineage (HP:0012130)11.0326688
76Down-sloping shoulders (HP:0200021)1.98514571
77Horseshoe kidney (HP:0000085)1.98191804
78Aplasia/Hypoplasia of the ulna (HP:0006495)1.96833721
79Respiratory failure (HP:0002878)1.95394589
80Increased muscle lipid content (HP:0009058)1.94482650
81Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93983169
82Seborrheic dermatitis (HP:0001051)1.92948293
83Atresia of the external auditory canal (HP:0000413)1.92563712
843-Methylglutaconic aciduria (HP:0003535)1.90826865
85Abnormality of the 2nd finger (HP:0004100)1.90614860
86Optic disc pallor (HP:0000543)1.89699162
87Missing ribs (HP:0000921)1.89495530
88Oral leukoplakia (HP:0002745)1.88942152
89Exercise intolerance (HP:0003546)1.88313620
90Abnormal urine phosphate concentration (HP:0012599)1.86471181
91Testicular atrophy (HP:0000029)1.86231623
92Hypoparathyroidism (HP:0000829)1.85336782
93Absent radius (HP:0003974)1.84999676
94Emotional lability (HP:0000712)1.84789763
95Microretrognathia (HP:0000308)1.82549148
96Glossoptosis (HP:0000162)1.82183523
97Leukodystrophy (HP:0002415)1.82084650
98Cone-rod dystrophy (HP:0000548)1.80846881
99Pancytopenia (HP:0001876)1.80192599
100Abnormality of urine glucose concentration (HP:0011016)1.79376248
101Glycosuria (HP:0003076)1.79376248
102Cerebral edema (HP:0002181)1.77938009
103Abnormality of placental membranes (HP:0011409)1.77610838
104Amniotic constriction ring (HP:0009775)1.77610838
105Gout (HP:0001997)1.77582533
106X-linked dominant inheritance (HP:0001423)1.77397533
107Pterygium (HP:0001059)1.76524159
108Absent forearm bone (HP:0003953)1.74699718
109Aplasia involving forearm bones (HP:0009822)1.74699718
110Hypotrichosis (HP:0001006)1.74270897
111Hydroureter (HP:0000072)1.73174388
112Squamous cell carcinoma (HP:0002860)1.73054875
113Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.72801018
114Vertebral hypoplasia (HP:0008417)1.72801018
115Severe visual impairment (HP:0001141)1.69834250
116Abnormal number of incisors (HP:0011064)1.69028727
117Short nose (HP:0003196)1.68938041
118Forearm undergrowth (HP:0009821)1.68595081
119Abnormal sex determination (HP:0012244)1.68461719
120Sex reversal (HP:0012245)1.68461719
121Carpal bone hypoplasia (HP:0001498)1.68403976
122Microvesicular hepatic steatosis (HP:0001414)1.68100617
123Rib fusion (HP:0000902)1.66077773
124Cleft eyelid (HP:0000625)1.65875929
125Esophageal atresia (HP:0002032)1.65849079
126Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.65697274
127Aplasia/Hypoplasia of the earlobes (HP:0009906)1.65028887
128Duplication of thumb phalanx (HP:0009942)1.64497426
129Hyperphosphaturia (HP:0003109)1.63111469
130Abnormality of the fetal cardiovascular system (HP:0010948)1.62544572
131Abnormal umbilical cord blood vessels (HP:0011403)1.62544572
132Single umbilical artery (HP:0001195)1.62544572
133Type I transferrin isoform profile (HP:0003642)1.62424245
134Patent foramen ovale (HP:0001655)1.59280098
135Symphalangism affecting the phalanges of the hand (HP:0009773)1.57269309
136Hypertensive crisis (HP:0100735)1.56182616
137Neoplasm of head and neck (HP:0012288)1.55765327
138Esophageal neoplasm (HP:0100751)1.55765327
139Nasolacrimal duct obstruction (HP:0000579)1.55336182
140Selective tooth agenesis (HP:0001592)1.54503258
141Striae distensae (HP:0001065)1.52804763
142Aplasia/Hypoplasia of the patella (HP:0006498)1.52711556
143Abnormality of renal resorption (HP:0011038)1.51781768
144Abnormality of the tricuspid valve (HP:0001702)1.50367306
145Onycholysis (HP:0001806)1.50304759
146Nail dystrophy (HP:0008404)1.48952600
147Patellar aplasia (HP:0006443)1.48753438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME27.12737244
2TLK15.90066145
3RPS6KB23.18207332
4LRRK23.05095665
5MST42.78474693
6VRK22.66787227
7BUB12.60018075
8KIT2.57742718
9TESK22.28795369
10EEF2K2.26251076
11BCKDK2.16607807
12EPHB22.11317839
13IRAK32.03219617
14NME12.00167125
15ILK1.99993425
16SRPK11.70162331
17PDK21.65621293
18DAPK31.54894108
19WEE11.54867220
20SMG11.54368562
21VRK11.49296290
22MAP2K21.47408176
23MAP3K101.45823879
24PIM21.42189637
25MAPKAPK31.37332052
26GRK61.36251893
27EPHA21.35814676
28AURKB1.20519238
29CLK11.18377386
30MST1R1.18150874
31MOS1.17772813
32LIMK11.16712160
33STK391.15291980
34TAOK31.14989179
35PAK21.11771920
36PLK41.11768774
37RPS6KA51.07444645
38STK161.06269130
39PAK11.05446238
40CDK191.04838511
41AURKA1.04696876
42FGR1.02061789
43ROCK21.01872868
44DYRK31.00751227
45SIK11.00739943
46TYRO30.96653883
47TEC0.95762096
48BLK0.94821841
49UHMK10.93592954
50PASK0.92291267
51STK100.92156393
52CSNK2A20.89984081
53MAP3K110.87992652
54NEK10.86772334
55MAP3K80.86102705
56MKNK10.85848178
57MAP4K10.84842929
58PBK0.81721226
59PKN20.77812360
60ADRBK10.77137327
61DYRK20.76739460
62RPS6KA60.76725834
63CHEK20.76287675
64CDK70.76270134
65PRKD20.74869763
66TGFBR10.74803021
67LATS20.73100440
68CHEK10.71335826
69ICK0.70781328
70WNK40.70367443
71MAPKAPK50.67990507
72ZAK0.67000313
73PLK10.66924890
74SIK20.66551546
75PNCK0.64468331
76PAK40.63204460
77BRSK10.61724419
78PRKCI0.61671209
79MET0.61548108
80MAP3K30.58925705
81DYRK1B0.58670467
82NEK20.58467960
83PKN10.57599500
84CDK40.56901526
85PIM10.56488958
86TAOK20.56286874
87CSNK2A10.54920782
88MUSK0.54361768
89DMPK0.53672833
90MARK30.52981275
91GRK50.52721962
92KDR0.51404378
93ATR0.50360505
94TESK10.49377113
95MKNK20.48266275
96NTRK20.48217302
97CDK30.47920699
98CSNK1E0.47792045
99GRK70.46768753
100CDK20.45739615
101AKT20.45330905
102IRAK40.45193318
103ARAF0.44524939
104PRKD10.44164322
105RPS6KA40.43732459
106IKBKB0.41322691
107TTK0.40662314
108EIF2AK10.36908097
109CDC70.36642680
110MAP3K20.36144193
111PRKCD0.35960363
112MAPKAPK20.35845137
113MAPK150.35824718
114PRKCQ0.35452019
115PDPK10.33980704
116RPS6KL10.33966280
117RPS6KC10.33966280
118FES0.33531148
119PRKACA0.33113707
120ABL20.32833031
121STK40.32370511
122CDK10.32199781
123RPS6KA10.31720638
124CSNK1G30.31716195
125CAMK2G0.30618299
126CCNB10.30078272
127BRAF0.29956848
128LCK0.29354016
129SCYL20.28858382
130CDK150.28698681
131CSNK1G10.28563903
132ERN10.28179746
133TTN0.27747407
134BMX0.27215731
135CDK11A0.27027359
136CSNK1D0.26637601
137MELK0.25760724
138CSNK1A10.25755652
139DDR20.25440362
140IKBKE0.24922682
141INSR0.24915204
142CDK90.24255596
143BTK0.24014968
144CDK80.23766633
145ATM0.23680056

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.05728576
2Parkinsons disease_Homo sapiens_hsa050123.54763155
3RNA polymerase_Homo sapiens_hsa030203.04289147
4Alzheimers disease_Homo sapiens_hsa050102.68670516
5Huntingtons disease_Homo sapiens_hsa050162.66150063
6Spliceosome_Homo sapiens_hsa030402.65015737
7Proteasome_Homo sapiens_hsa030502.53684600
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.40109726
9* Ribosome_Homo sapiens_hsa0301010.3926622
10Protein export_Homo sapiens_hsa030601.87666834
11DNA replication_Homo sapiens_hsa030301.84168774
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75693390
13Mismatch repair_Homo sapiens_hsa034301.72256769
14Pyrimidine metabolism_Homo sapiens_hsa002401.65214749
15Systemic lupus erythematosus_Homo sapiens_hsa053221.58614443
16Cardiac muscle contraction_Homo sapiens_hsa042601.53455843
17Nucleotide excision repair_Homo sapiens_hsa034201.48024835
18RNA transport_Homo sapiens_hsa030131.42345701
19Homologous recombination_Homo sapiens_hsa034401.36712218
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36584423
21Sulfur relay system_Homo sapiens_hsa041221.28075338
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.27658190
23Folate biosynthesis_Homo sapiens_hsa007901.21282541
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97925827
25Drug metabolism - other enzymes_Homo sapiens_hsa009830.97064606
26One carbon pool by folate_Homo sapiens_hsa006700.92959120
27Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90339006
28Alcoholism_Homo sapiens_hsa050340.87793116
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85783309
30Basal transcription factors_Homo sapiens_hsa030220.85099967
31Base excision repair_Homo sapiens_hsa034100.83087886
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80963098
33Basal cell carcinoma_Homo sapiens_hsa052170.80209073
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76484478
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76406720
36RNA degradation_Homo sapiens_hsa030180.75377125
37p53 signaling pathway_Homo sapiens_hsa041150.74306094
38Fanconi anemia pathway_Homo sapiens_hsa034600.74272276
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71494390
40Hedgehog signaling pathway_Homo sapiens_hsa043400.70194812
41Primary immunodeficiency_Homo sapiens_hsa053400.69512745
42Vitamin B6 metabolism_Homo sapiens_hsa007500.69378373
43Epstein-Barr virus infection_Homo sapiens_hsa051690.68791085
44Non-homologous end-joining_Homo sapiens_hsa034500.66844406
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66312994
46Arachidonic acid metabolism_Homo sapiens_hsa005900.64940552
47Linoleic acid metabolism_Homo sapiens_hsa005910.63863818
48Glutathione metabolism_Homo sapiens_hsa004800.62947162
49Cell cycle_Homo sapiens_hsa041100.62579468
50Arginine and proline metabolism_Homo sapiens_hsa003300.61348187
51Purine metabolism_Homo sapiens_hsa002300.60779477
52mRNA surveillance pathway_Homo sapiens_hsa030150.60496079
53Bladder cancer_Homo sapiens_hsa052190.59491510
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56446508
55Tyrosine metabolism_Homo sapiens_hsa003500.53865647
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.53425803
57Pyruvate metabolism_Homo sapiens_hsa006200.50099514
58Viral carcinogenesis_Homo sapiens_hsa052030.49809440
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.48974985
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48789218
61Chemical carcinogenesis_Homo sapiens_hsa052040.48664577
62Galactose metabolism_Homo sapiens_hsa000520.47070678
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46788965
64Biosynthesis of amino acids_Homo sapiens_hsa012300.45927436
65Ether lipid metabolism_Homo sapiens_hsa005650.44141188
66Antigen processing and presentation_Homo sapiens_hsa046120.43884764
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41085016
68Hematopoietic cell lineage_Homo sapiens_hsa046400.39471598
69Small cell lung cancer_Homo sapiens_hsa052220.38283450
70Thyroid cancer_Homo sapiens_hsa052160.38125430
71HTLV-I infection_Homo sapiens_hsa051660.37648986
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34924217
73TGF-beta signaling pathway_Homo sapiens_hsa043500.34498162
74Retinol metabolism_Homo sapiens_hsa008300.34147129
75Carbon metabolism_Homo sapiens_hsa012000.34109751
76Pathways in cancer_Homo sapiens_hsa052000.33897244
77Hippo signaling pathway_Homo sapiens_hsa043900.33014435
78Peroxisome_Homo sapiens_hsa041460.32811107
79Vitamin digestion and absorption_Homo sapiens_hsa049770.32118903
80ECM-receptor interaction_Homo sapiens_hsa045120.31066450
81MicroRNAs in cancer_Homo sapiens_hsa052060.30910273
82Tight junction_Homo sapiens_hsa045300.30434541
83Wnt signaling pathway_Homo sapiens_hsa043100.29486053
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29216605
85Graft-versus-host disease_Homo sapiens_hsa053320.28994096
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28721668
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28594233
88T cell receptor signaling pathway_Homo sapiens_hsa046600.28293260
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27848847
90Notch signaling pathway_Homo sapiens_hsa043300.26453280
91Metabolic pathways_Homo sapiens_hsa011000.26303089
92Collecting duct acid secretion_Homo sapiens_hsa049660.26250980
93VEGF signaling pathway_Homo sapiens_hsa043700.26046137
94Renal cell carcinoma_Homo sapiens_hsa052110.25853951
95Melanoma_Homo sapiens_hsa052180.25784583
96Fatty acid elongation_Homo sapiens_hsa000620.25162455
97Axon guidance_Homo sapiens_hsa043600.25095856
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24973190
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23975560
100Proteoglycans in cancer_Homo sapiens_hsa052050.22966504
101Sulfur metabolism_Homo sapiens_hsa009200.22836015
102Melanogenesis_Homo sapiens_hsa049160.22717899
103Fructose and mannose metabolism_Homo sapiens_hsa000510.22554468
104beta-Alanine metabolism_Homo sapiens_hsa004100.22167362
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21924249
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.21777021
107Prostate cancer_Homo sapiens_hsa052150.21767228
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20414901
109Pentose phosphate pathway_Homo sapiens_hsa000300.20025987
110Apoptosis_Homo sapiens_hsa042100.19360162
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19210528
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19022569
113HIF-1 signaling pathway_Homo sapiens_hsa040660.18513894
114Chronic myeloid leukemia_Homo sapiens_hsa052200.17284515
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17028323
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.16830314
117Phototransduction_Homo sapiens_hsa047440.16700747
118Herpes simplex infection_Homo sapiens_hsa051680.16504362
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15861638
120Starch and sucrose metabolism_Homo sapiens_hsa005000.15650872
121N-Glycan biosynthesis_Homo sapiens_hsa005100.15084746
122Ras signaling pathway_Homo sapiens_hsa040140.15062215
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14418608
124Sphingolipid metabolism_Homo sapiens_hsa006000.13912936
125Asthma_Homo sapiens_hsa053100.13843983
126Acute myeloid leukemia_Homo sapiens_hsa052210.13767804
127B cell receptor signaling pathway_Homo sapiens_hsa046620.13617614
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13441104
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.12501466
130Phenylalanine metabolism_Homo sapiens_hsa003600.11405276
131Fat digestion and absorption_Homo sapiens_hsa049750.11232623
132Autoimmune thyroid disease_Homo sapiens_hsa053200.10719228
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.10613919
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.10361046
135Caffeine metabolism_Homo sapiens_hsa002320.10187657
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.08180385
137Tryptophan metabolism_Homo sapiens_hsa003800.04166822
138Olfactory transduction_Homo sapiens_hsa047400.02829481
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.01246317
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.00281938
141Mineral absorption_Homo sapiens_hsa04978-0.0311461
142Maturity onset diabetes of the young_Homo sapiens_hsa04950-0.0182137

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