RPS21P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)8.60229435
2viral transcription (GO:0019083)7.70073933
3translational termination (GO:0006415)7.38854742
4ribosomal small subunit assembly (GO:0000028)7.32568958
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.35414744
6protein targeting to ER (GO:0045047)6.31181201
7translational elongation (GO:0006414)6.24429798
8cotranslational protein targeting to membrane (GO:0006613)6.22107753
9maturation of SSU-rRNA (GO:0030490)6.13510272
10establishment of protein localization to endoplasmic reticulum (GO:0072599)6.01578144
11protein localization to endoplasmic reticulum (GO:0070972)5.99225448
12viral life cycle (GO:0019058)5.62741508
13cellular protein complex disassembly (GO:0043624)5.60172216
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.28993759
15energy coupled proton transport, down electrochemical gradient (GO:0015985)5.20747290
16ATP synthesis coupled proton transport (GO:0015986)5.20747290
17establishment of protein localization to mitochondrial membrane (GO:0090151)5.12315855
18chaperone-mediated protein transport (GO:0072321)4.93177899
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.92726461
20pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.86905276
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.85103813
22translational initiation (GO:0006413)4.74325160
23protein complex disassembly (GO:0043241)4.70808895
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.67929292
25macromolecular complex disassembly (GO:0032984)4.49238932
26behavioral response to nicotine (GO:0035095)4.37385665
27respiratory electron transport chain (GO:0022904)4.36464736
28electron transport chain (GO:0022900)4.33338198
29protein complex biogenesis (GO:0070271)4.25019203
30protein targeting to membrane (GO:0006612)4.23625613
31mitochondrial respiratory chain complex I assembly (GO:0032981)4.13244233
32NADH dehydrogenase complex assembly (GO:0010257)4.13244233
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.13244233
34translation (GO:0006412)4.10966382
35pyrimidine nucleotide catabolic process (GO:0006244)4.09702537
36ncRNA 3-end processing (GO:0043628)4.09653284
37DNA deamination (GO:0045006)3.96583594
38motile cilium assembly (GO:0044458)3.91005051
39mitochondrial respiratory chain complex assembly (GO:0033108)3.85429460
40deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.84760955
41response to pheromone (GO:0019236)3.83052062
42protein neddylation (GO:0045116)3.76801584
43GTP biosynthetic process (GO:0006183)3.65057098
44pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.64279392
45nuclear-transcribed mRNA catabolic process (GO:0000956)3.61494053
46cellular component biogenesis (GO:0044085)3.51863098
47ribonucleoprotein complex biogenesis (GO:0022613)3.47582760
48ribosomal large subunit biogenesis (GO:0042273)3.45533842
49mRNA catabolic process (GO:0006402)3.41901345
50cardiovascular system development (GO:0072358)3.40062644
51epithelial cilium movement (GO:0003351)3.38310257
52tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.24983773
53RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.24983773
54purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.19343272
55tongue development (GO:0043586)3.17178263
56axonemal dynein complex assembly (GO:0070286)3.15448936
57purine nucleoside triphosphate biosynthetic process (GO:0009145)3.15417239
58UTP biosynthetic process (GO:0006228)3.12069630
59substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.07266899
60substrate-independent telencephalic tangential migration (GO:0021826)3.07266899
61hydrogen ion transmembrane transport (GO:1902600)3.07256165
62ATP biosynthetic process (GO:0006754)3.04907327
63regulation of cilium movement (GO:0003352)3.04255406
64iron-sulfur cluster assembly (GO:0016226)3.02691320
65metallo-sulfur cluster assembly (GO:0031163)3.02691320
66RNA catabolic process (GO:0006401)2.99281882
67nonmotile primary cilium assembly (GO:0035058)2.94706400
68cytidine metabolic process (GO:0046087)2.94376502
69cytidine catabolic process (GO:0006216)2.94376502
70cytidine deamination (GO:0009972)2.94376502
71axoneme assembly (GO:0035082)2.93437961
72regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.93233097
73protein targeting (GO:0006605)2.92511740
74establishment of protein localization to membrane (GO:0090150)2.89029751
75deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.85244165
76cell proliferation in forebrain (GO:0021846)2.84229064
77UTP metabolic process (GO:0046051)2.82662608
78intracellular protein transmembrane import (GO:0044743)2.80442457
79proton transport (GO:0015992)2.78069431
80deoxyribonucleotide catabolic process (GO:0009264)2.76877360
81cilium movement (GO:0003341)2.74581728
82protein targeting to mitochondrion (GO:0006626)2.73838207
83cellular ketone body metabolic process (GO:0046950)2.73204684
84ribonucleoside triphosphate biosynthetic process (GO:0009201)2.72228212
85hydrogen transport (GO:0006818)2.72025254
86platelet dense granule organization (GO:0060155)2.70494536
87transcription elongation from RNA polymerase III promoter (GO:0006385)2.70303768
88termination of RNA polymerase III transcription (GO:0006386)2.70303768
89axon ensheathment in central nervous system (GO:0032291)2.68715847
90central nervous system myelination (GO:0022010)2.68715847
91water-soluble vitamin biosynthetic process (GO:0042364)2.68220877
92pyrimidine nucleobase catabolic process (GO:0006208)2.68168028
93positive regulation of respiratory burst (GO:0060267)2.67609017
94intraciliary transport (GO:0042073)2.66894391
95deoxyribose phosphate catabolic process (GO:0046386)2.62743232
96cytochrome complex assembly (GO:0017004)2.62240545
97regulation of mitochondrial translation (GO:0070129)2.61994946
98establishment of protein localization to mitochondrion (GO:0072655)2.61728971
99establishment of protein localization to organelle (GO:0072594)2.61557496
100negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.58368885

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.93400274
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.60103040
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.54902568
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.09897746
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.88583264
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.70867547
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.69606755
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.69540174
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.56464989
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39890867
11IGF1R_20145208_ChIP-Seq_DFB_Human2.34851081
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.23522550
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.06593472
14ZNF274_21170338_ChIP-Seq_K562_Hela2.00220407
15CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.95977083
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89688691
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84189800
18VDR_22108803_ChIP-Seq_LS180_Human1.76505106
19VDR_23849224_ChIP-Seq_CD4+_Human1.68889333
20CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.68189573
21MYC_18940864_ChIP-ChIP_HL60_Human1.65469694
22GABP_19822575_ChIP-Seq_HepG2_Human1.59523276
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.59360753
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.56858038
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50615252
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50283209
27ETV2_25802403_ChIP-Seq_MESCs_Mouse1.48750858
28RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.48677770
29IRF1_19129219_ChIP-ChIP_H3396_Human1.48648866
30EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.48471431
31ERA_21632823_ChIP-Seq_H3396_Human1.48375318
32NANOG_20526341_ChIP-Seq_ESCs_Human1.47990555
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.45972436
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.42543154
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42041712
36TAF2_19829295_ChIP-Seq_ESCs_Human1.42023054
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.41732985
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.40300223
39GATA3_21878914_ChIP-Seq_MCF-7_Human1.37707355
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33792266
41CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.31797222
42CTCF_18555785_ChIP-Seq_MESCs_Mouse1.31234867
43SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29556925
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27433319
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26233180
46CTCF_27219007_Chip-Seq_Bcells_Human1.25693922
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.24643135
48FOXP3_21729870_ChIP-Seq_TREG_Human1.22997141
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22849013
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22415541
51XRN2_22483619_ChIP-Seq_HELA_Human1.21836713
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.21397895
53MYC_19829295_ChIP-Seq_ESCs_Human1.19792417
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.19082384
55BCL6_27268052_Chip-Seq_Bcells_Human1.18323853
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18004686
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17945084
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17064940
59NCOR_22424771_ChIP-Seq_293T_Human1.16385345
60TP53_22573176_ChIP-Seq_HFKS_Human1.14705122
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13489705
62PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13482922
63WDR5_24793694_ChIP-Seq_LNCAP_Human1.13407974
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12030481
65STAT1_20625510_ChIP-Seq_HELA_Human1.11862219
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11797981
67EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.11469642
68CTCF_20526341_ChIP-Seq_ESCs_Human1.11435979
69AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09867223
70TTF2_22483619_ChIP-Seq_HELA_Human1.07919580
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07909167
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06603456
73JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06500913
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06229298
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04231621
76ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02851741
77RNF2_27304074_Chip-Seq_NSC_Mouse1.01839091
78YY1_22570637_ChIP-Seq_MALME-3M_Human1.01634381
79SA1_27219007_Chip-Seq_Bcells_Human0.98859934
80REST_18959480_ChIP-ChIP_MESCs_Mouse0.96985137
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96785869
82ER_23166858_ChIP-Seq_MCF-7_Human0.96713418
83E2F1_20622854_ChIP-Seq_HELA_Human0.96557700
84SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96343985
85POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95527869
86KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95252777
87GATA1_26923725_Chip-Seq_HPCs_Mouse0.94772821
88FOXP1_21924763_ChIP-Seq_HESCs_Human0.94588473
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94466958
90REST_21632747_ChIP-Seq_MESCs_Mouse0.93907192
91MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.93626910
92RAC3_21632823_ChIP-Seq_H3396_Human0.93586971
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93138215
94FOXH1_21741376_ChIP-Seq_EPCs_Human0.90618979
95SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90326239
96AR_20517297_ChIP-Seq_VCAP_Human0.89870698
97EWS_26573619_Chip-Seq_HEK293_Human0.89069644
98CIITA_25753668_ChIP-Seq_RAJI_Human0.88026989
99EZH2_18974828_ChIP-Seq_MESCs_Mouse0.87019882
100RNF2_18974828_ChIP-Seq_MESCs_Mouse0.87019882

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.51699285
2MP0006292_abnormal_olfactory_placode4.06285238
3MP0002163_abnormal_gland_morphology2.95765627
4MP0003136_yellow_coat_color2.92506167
5MP0003646_muscle_fatigue2.82363252
6MP0005646_abnormal_pituitary_gland2.59608244
7MP0002653_abnormal_ependyma_morphology2.56061288
8MP0008789_abnormal_olfactory_epithelium2.47323131
9MP0005377_hearing/vestibular/ear_phenot2.44068793
10MP0003878_abnormal_ear_physiology2.44068793
11MP0005394_taste/olfaction_phenotype2.28239889
12MP0005499_abnormal_olfactory_system2.28239889
13MP0003787_abnormal_imprinting2.27981512
14MP0002102_abnormal_ear_morphology2.20917061
15MP0003122_maternal_imprinting2.13869665
16MP0002638_abnormal_pupillary_reflex2.13744332
17MP0002837_dystrophic_cardiac_calcinosis1.84403881
18MP0000049_abnormal_middle_ear1.82257625
19MP0003123_paternal_imprinting1.81877038
20MP0001485_abnormal_pinna_reflex1.78669212
21MP0004142_abnormal_muscle_tone1.78542564
22MP0001984_abnormal_olfaction1.77385669
23MP0003011_delayed_dark_adaptation1.74182693
24MP0002160_abnormal_reproductive_system1.72867426
25MP0005551_abnormal_eye_electrophysiolog1.70501345
26MP0005379_endocrine/exocrine_gland_phen1.68958827
27MP0001188_hyperpigmentation1.63574836
28MP0008877_abnormal_DNA_methylation1.60030069
29MP0006072_abnormal_retinal_apoptosis1.58118311
30MP0001986_abnormal_taste_sensitivity1.56038992
31MP0005174_abnormal_tail_pigmentation1.55830353
32MP0002095_abnormal_skin_pigmentation1.54441628
33MP0002876_abnormal_thyroid_physiology1.54136315
34MP0002132_abnormal_respiratory_system1.44842978
35MP0006276_abnormal_autonomic_nervous1.42443121
36MP0003121_genomic_imprinting1.28753155
37MP0003315_abnormal_perineum_morphology1.27973467
38MP0001968_abnormal_touch/_nociception1.26021337
39MP0005389_reproductive_system_phenotype1.25510798
40MP0005195_abnormal_posterior_eye1.22821910
41MP0001905_abnormal_dopamine_level1.21278573
42MP0003880_abnormal_central_pattern1.21251724
43MP0003938_abnormal_ear_development1.19060251
44MP0000631_abnormal_neuroendocrine_gland1.18637000
45MP0005084_abnormal_gallbladder_morpholo1.18061415
46MP0005645_abnormal_hypothalamus_physiol1.17531737
47MP0002234_abnormal_pharynx_morphology1.15914883
48MP0000678_abnormal_parathyroid_gland1.15821524
49MP0002272_abnormal_nervous_system1.13950238
50MP0005253_abnormal_eye_physiology1.11163508
51MP0001293_anophthalmia1.10618229
52MP0001764_abnormal_homeostasis1.07291977
53MP0002277_abnormal_respiratory_mucosa1.06660042
54MP0000026_abnormal_inner_ear1.06212921
55MP0002249_abnormal_larynx_morphology1.05012243
56MP0005671_abnormal_response_to1.03051263
57MP0001529_abnormal_vocalization1.02872334
58MP0000778_abnormal_nervous_system1.02604574
59MP0002938_white_spotting1.02595060
60MP0009745_abnormal_behavioral_response1.02494042
61MP0002752_abnormal_somatic_nervous1.00739597
62MP0005410_abnormal_fertilization1.00307222
63MP0003879_abnormal_hair_cell0.99229232
64MP0002733_abnormal_thermal_nociception0.98977147
65MP0002138_abnormal_hepatobiliary_system0.98868920
66MP0006036_abnormal_mitochondrial_physio0.98463221
67MP0000372_irregular_coat_pigmentation0.98390304
68MP0001486_abnormal_startle_reflex0.97730609
69MP0004145_abnormal_muscle_electrophysio0.97366847
70MP0001970_abnormal_pain_threshold0.94832600
71MP0008875_abnormal_xenobiotic_pharmacok0.92182189
72MP0001963_abnormal_hearing_physiology0.92138322
73MP0001919_abnormal_reproductive_system0.91600533
74MP0002233_abnormal_nose_morphology0.90874650
75MP0003186_abnormal_redox_activity0.90621250
76MP0000015_abnormal_ear_pigmentation0.89062565
77MP0002557_abnormal_social/conspecific_i0.86760349
78MP0009046_muscle_twitch0.86307732
79MP0005391_vision/eye_phenotype0.85901379
80MP0010386_abnormal_urinary_bladder0.85733726
81MP0010030_abnormal_orbit_morphology0.81004647
82MP0001270_distended_abdomen0.80377438
83MP0002210_abnormal_sex_determination0.79872492
84MP0004742_abnormal_vestibular_system0.79170268
85MP0002736_abnormal_nociception_after0.79052857
86MP0004381_abnormal_hair_follicle0.76067761
87MP0005187_abnormal_penis_morphology0.75621209
88MP0004885_abnormal_endolymph0.74681367
89MP0003942_abnormal_urinary_system0.72741571
90MP0001324_abnormal_eye_pigmentation0.70575240
91MP0002184_abnormal_innervation0.69840807
92MP0008872_abnormal_physiological_respon0.69097595
93MP0004043_abnormal_pH_regulation0.66831023
94MP0005248_abnormal_Harderian_gland0.65752404
95MP0004133_heterotaxia0.65058717
96MP0000955_abnormal_spinal_cord0.63648814
97MP0003806_abnormal_nucleotide_metabolis0.62828035
98MP0002822_catalepsy0.62740383
99MP0001119_abnormal_female_reproductive0.62060050
100MP0003119_abnormal_digestive_system0.62006635

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.00654447
2Reticulocytopenia (HP:0001896)4.68719352
3Abnormal mitochondria in muscle tissue (HP:0008316)4.58026953
4Mitochondrial inheritance (HP:0001427)4.42271929
5Pancreatic fibrosis (HP:0100732)4.23548467
6Acute encephalopathy (HP:0006846)4.19041760
7Progressive macrocephaly (HP:0004481)4.18437358
8Abnormality of midbrain morphology (HP:0002418)3.92796758
9Molar tooth sign on MRI (HP:0002419)3.92796758
10Abnormality of cells of the erythroid lineage (HP:0012130)3.89768601
11Increased CSF lactate (HP:0002490)3.68524475
12Pancreatic cysts (HP:0001737)3.54036651
13True hermaphroditism (HP:0010459)3.53326947
14Hepatocellular necrosis (HP:0001404)3.42315438
15Lipid accumulation in hepatocytes (HP:0006561)3.36495557
16Macrocytic anemia (HP:0001972)3.32735819
17Increased intramyocellular lipid droplets (HP:0012240)3.30097428
18Increased hepatocellular lipid droplets (HP:0006565)3.29719008
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.23295453
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.23295453
213-Methylglutaconic aciduria (HP:0003535)3.16143660
22Cerebral edema (HP:0002181)3.14681432
23Renal Fanconi syndrome (HP:0001994)3.09531370
24Absent thumb (HP:0009777)3.08988784
25Increased muscle lipid content (HP:0009058)3.03810201
26Hepatic necrosis (HP:0002605)2.97113203
27Congenital stationary night blindness (HP:0007642)2.96413321
28Cystic liver disease (HP:0006706)2.91112359
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.89879357
30Abnormal number of erythroid precursors (HP:0012131)2.89859654
31Nephronophthisis (HP:0000090)2.84991078
32Abnormal rod and cone electroretinograms (HP:0008323)2.74872817
33Type II lissencephaly (HP:0007260)2.72948187
34Anencephaly (HP:0002323)2.69457465
35Pallor (HP:0000980)2.68396636
36Medial flaring of the eyebrow (HP:0010747)2.65337503
37Absent/shortened dynein arms (HP:0200106)2.61224591
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.61224591
39Abnormal respiratory motile cilium morphology (HP:0005938)2.57823290
40Abnormal respiratory epithelium morphology (HP:0012253)2.57823290
41Sclerocornea (HP:0000647)2.55373147
42Abnormality of DNA repair (HP:0003254)2.49453053
43Optic disc pallor (HP:0000543)2.45353516
44Hyperglycinemia (HP:0002154)2.44820898
45Abnormal ciliary motility (HP:0012262)2.38103783
46Gait imbalance (HP:0002141)2.36112905
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.36050189
48Retinal dysplasia (HP:0007973)2.33438319
49Congenital primary aphakia (HP:0007707)2.32659198
50Stenosis of the external auditory canal (HP:0000402)2.30955737
51Myokymia (HP:0002411)2.30255472
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.29378271
53Asplenia (HP:0001746)2.28721104
54Aplasia/Hypoplasia of the spleen (HP:0010451)2.28587039
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.27424058
56Abnormality of the renal medulla (HP:0100957)2.24952066
57Postaxial foot polydactyly (HP:0001830)2.22345204
58Abnormal respiratory motile cilium physiology (HP:0012261)2.21742773
59Colon cancer (HP:0003003)2.21436860
60Lactic acidosis (HP:0003128)2.17088635
61Exercise intolerance (HP:0003546)2.13890321
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.11856023
63Pendular nystagmus (HP:0012043)2.09581282
64Lethargy (HP:0001254)2.09325252
65Nephrogenic diabetes insipidus (HP:0009806)2.08784765
66Hyperthyroidism (HP:0000836)2.07876098
67Respiratory failure (HP:0002878)2.07651177
68Concave nail (HP:0001598)2.05942396
69Male pseudohermaphroditism (HP:0000037)2.03188106
70Severe visual impairment (HP:0001141)2.02050665
71Abnormality of renal resorption (HP:0011038)1.99148951
72Supernumerary spleens (HP:0009799)1.98987349
73Hyperglycinuria (HP:0003108)1.98530135
74Increased serum lactate (HP:0002151)1.97880013
75Depressed nasal ridge (HP:0000457)1.97566181
76Leukodystrophy (HP:0002415)1.96723925
77Exertional dyspnea (HP:0002875)1.96523559
78Occipital encephalocele (HP:0002085)1.94071695
79Respiratory difficulties (HP:0002880)1.92476464
80Septo-optic dysplasia (HP:0100842)1.91018698
81Renal dysplasia (HP:0000110)1.90375542
82Glycosuria (HP:0003076)1.90203427
83Abnormality of urine glucose concentration (HP:0011016)1.90203427
84Abnormal drinking behavior (HP:0030082)1.89506845
85Polydipsia (HP:0001959)1.89506845
86Triphalangeal thumb (HP:0001199)1.88563329
87Hypoplasia of the radius (HP:0002984)1.88236766
88Chronic hepatic failure (HP:0100626)1.87745136
89Adrenal hypoplasia (HP:0000835)1.86541495
90Aplastic anemia (HP:0001915)1.85955224
91Abolished electroretinogram (ERG) (HP:0000550)1.85721599
92Aplasia/Hypoplasia of the tongue (HP:0010295)1.83276363
93Congenital hepatic fibrosis (HP:0002612)1.79392794
94Microretrognathia (HP:0000308)1.78098908
95Preaxial hand polydactyly (HP:0001177)1.76723258
96Abnormality of serine family amino acid metabolism (HP:0010894)1.74524862
97Abnormality of glycine metabolism (HP:0010895)1.74524862
98Postaxial hand polydactyly (HP:0001162)1.73897202
99Abnormality of the renal cortex (HP:0011035)1.72457521
100Partial duplication of thumb phalanx (HP:0009944)1.71549059

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK13.57230855
2MAP4K23.46332975
3STK163.27553995
4GRK13.12968934
5TESK23.05691549
6BCKDK2.93015196
7ZAK2.93003653
8ADRBK22.73726172
9TXK2.72259296
10WNK42.51598874
11PIK3CA2.42476903
12DYRK22.39726308
13NME22.27589215
14CDK192.14955303
15LRRK22.04476839
16KDR1.98750958
17TLK11.68499205
18FRK1.62986323
19MARK31.55783854
20MAP3K111.52901894
21NTRK21.46997335
22PDK21.41176357
23CAMKK21.39249852
24TIE11.37395667
25PRKCQ1.36150133
26TRIM281.32573093
27WNK31.31322712
28CAMK11.25806824
29NUAK11.25493934
30MAP2K71.17784685
31EPHA41.12213962
32MYLK1.05324904
33OBSCN1.03387092
34MAP3K121.02153429
35CASK1.01259590
36BMPR1B0.92227433
37MINK10.88372056
38CAMKK10.88321480
39PRKCG0.87050789
40LIMK10.86587760
41MAPK150.85770363
42ADRBK10.85004115
43CSNK1G30.85000959
44RPS6KA50.79168161
45NEK10.77208903
46DYRK30.77188886
47RPS6KA40.76439895
48TNIK0.75461788
49NME10.74640207
50INSRR0.74561599
51ITK0.74186906
52MAPK130.74048274
53CAMK1D0.72928674
54CSNK2A20.72291602
55PAK30.72223660
56STK390.71929809
57CSNK1G20.70440637
58VRK10.69244770
59AURKB0.67742168
60AURKA0.64951150
61PRKACA0.64229895
62SGK2230.63442077
63SGK4940.63442077
64DYRK1B0.62642061
65NLK0.60734593
66CSNK1A1L0.59678562
67ABL20.59055590
68CSNK2A10.58421164
69PLK10.57208363
70CSNK1A10.57032234
71ILK0.56116202
72PRKD30.55532873
73CSNK1G10.54625950
74STK38L0.54000481
75MAP4K10.52224747
76NEK20.51758871
77DAPK30.48801025
78MAP3K40.47800660
79STK110.47494462
80GRK70.46121155
81MAP3K90.42986711
82PRKCA0.39471439
83VRK20.38793009
84MARK20.38480538
85PRKCH0.36537737
86BTK0.35829693
87ATR0.35643295
88CSNK1E0.35310612
89AKT20.35107783
90RPS6KB10.35079576
91CAMK1G0.34508284
92CAMK2A0.34436741
93PRKCI0.33940205
94RPS6KA60.31635203
95PAK10.31105959
96SGK10.30154336
97PRKCE0.29877772
98CAMK2D0.29306164
99CAMK40.28995956
100PRKCZ0.28762157

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.63315571
2Oxidative phosphorylation_Homo sapiens_hsa001904.68980941
3Parkinsons disease_Homo sapiens_hsa050124.10984996
4Huntingtons disease_Homo sapiens_hsa050162.88844097
5Alzheimers disease_Homo sapiens_hsa050102.68678327
6Cardiac muscle contraction_Homo sapiens_hsa042602.63332835
7RNA polymerase_Homo sapiens_hsa030202.61710010
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.61531263
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.57486946
10Butanoate metabolism_Homo sapiens_hsa006502.13116737
11Protein export_Homo sapiens_hsa030602.05844170
12Sulfur relay system_Homo sapiens_hsa041222.01932028
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00479163
14Phototransduction_Homo sapiens_hsa047441.80891424
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.79473216
16Pyrimidine metabolism_Homo sapiens_hsa002401.61715762
17Linoleic acid metabolism_Homo sapiens_hsa005911.56147557
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54424429
19Peroxisome_Homo sapiens_hsa041461.52513363
20Proteasome_Homo sapiens_hsa030501.45275250
21Primary immunodeficiency_Homo sapiens_hsa053401.45198826
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44080142
23Fanconi anemia pathway_Homo sapiens_hsa034601.37719857
24One carbon pool by folate_Homo sapiens_hsa006701.34010701
25Olfactory transduction_Homo sapiens_hsa047401.33414928
26Homologous recombination_Homo sapiens_hsa034401.25608521
27Basal transcription factors_Homo sapiens_hsa030221.09545238
28Hedgehog signaling pathway_Homo sapiens_hsa043401.07937676
29Propanoate metabolism_Homo sapiens_hsa006401.06184596
30Purine metabolism_Homo sapiens_hsa002301.04974643
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04064185
32Folate biosynthesis_Homo sapiens_hsa007901.01545793
33Steroid biosynthesis_Homo sapiens_hsa001000.99567369
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96493091
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93452087
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93135482
37RNA degradation_Homo sapiens_hsa030180.91601737
38Nucleotide excision repair_Homo sapiens_hsa034200.90839028
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90311905
40Metabolic pathways_Homo sapiens_hsa011000.90004205
41Fat digestion and absorption_Homo sapiens_hsa049750.89465222
42Steroid hormone biosynthesis_Homo sapiens_hsa001400.88951785
43Nitrogen metabolism_Homo sapiens_hsa009100.88163707
44Chemical carcinogenesis_Homo sapiens_hsa052040.85392295
45Retinol metabolism_Homo sapiens_hsa008300.85233595
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83920604
47Primary bile acid biosynthesis_Homo sapiens_hsa001200.81761789
48Base excision repair_Homo sapiens_hsa034100.81337168
49Ether lipid metabolism_Homo sapiens_hsa005650.81309687
50Basal cell carcinoma_Homo sapiens_hsa052170.81269162
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78171911
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75932463
53Tryptophan metabolism_Homo sapiens_hsa003800.73451265
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72552320
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72010788
56Arachidonic acid metabolism_Homo sapiens_hsa005900.70354562
57beta-Alanine metabolism_Homo sapiens_hsa004100.69748018
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68363669
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67960810
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65529845
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61415640
62Regulation of autophagy_Homo sapiens_hsa041400.60470029
63Pyruvate metabolism_Homo sapiens_hsa006200.56841432
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.56490841
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53698928
66Nicotine addiction_Homo sapiens_hsa050330.52302226
67Fatty acid degradation_Homo sapiens_hsa000710.51859743
68Morphine addiction_Homo sapiens_hsa050320.48461999
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48340720
70ABC transporters_Homo sapiens_hsa020100.46682915
71Glutathione metabolism_Homo sapiens_hsa004800.46621230
72Arginine and proline metabolism_Homo sapiens_hsa003300.46087029
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.46079178
74Collecting duct acid secretion_Homo sapiens_hsa049660.44876966
75Taste transduction_Homo sapiens_hsa047420.42036560
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41718711
77DNA replication_Homo sapiens_hsa030300.40633795
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.40393912
79Mismatch repair_Homo sapiens_hsa034300.38875084
80Caffeine metabolism_Homo sapiens_hsa002320.37583247
81Insulin secretion_Homo sapiens_hsa049110.31262090
82Spliceosome_Homo sapiens_hsa030400.30874121
83GABAergic synapse_Homo sapiens_hsa047270.30591604
84Ovarian steroidogenesis_Homo sapiens_hsa049130.30093654
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25663783
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.24084455
87Hematopoietic cell lineage_Homo sapiens_hsa046400.22743559
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.22652647
89Systemic lupus erythematosus_Homo sapiens_hsa053220.20440185
90RNA transport_Homo sapiens_hsa030130.19715944
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19474616
92Glycerolipid metabolism_Homo sapiens_hsa005610.18529350
93Bile secretion_Homo sapiens_hsa049760.17654457
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16617676
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14626017
96Serotonergic synapse_Homo sapiens_hsa047260.14169716
97Salivary secretion_Homo sapiens_hsa049700.13607560
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.12211457
99Calcium signaling pathway_Homo sapiens_hsa040200.10524261
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.10253573

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