

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 9.66090224 |
| 2 | * SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 8.75243763 |
| 3 | * cotranslational protein targeting to membrane (GO:0006613) | 8.62476118 |
| 4 | * protein targeting to ER (GO:0045047) | 8.60981232 |
| 5 | * translational elongation (GO:0006414) | 8.59196097 |
| 6 | * establishment of protein localization to endoplasmic reticulum (GO:0072599) | 8.23729180 |
| 7 | * protein localization to endoplasmic reticulum (GO:0070972) | 8.06115333 |
| 8 | * cellular protein complex disassembly (GO:0043624) | 7.98409697 |
| 9 | * viral life cycle (GO:0019058) | 7.94215137 |
| 10 | * nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 7.91117132 |
| 11 | maturation of SSU-rRNA (GO:0030490) | 7.63838396 |
| 12 | * translational initiation (GO:0006413) | 7.38812273 |
| 13 | ribosomal large subunit biogenesis (GO:0042273) | 7.32423853 |
| 14 | * protein complex disassembly (GO:0043241) | 6.88759781 |
| 15 | * macromolecular complex disassembly (GO:0032984) | 6.44802390 |
| 16 | * protein targeting to membrane (GO:0006612) | 5.71348701 |
| 17 | * nuclear-transcribed mRNA catabolic process (GO:0000956) | 5.57678043 |
| 18 | * translation (GO:0006412) | 5.32670656 |
| 19 | * mRNA catabolic process (GO:0006402) | 5.31422861 |
| 20 | ribonucleoprotein complex biogenesis (GO:0022613) | 5.22813070 |
| 21 | * RNA catabolic process (GO:0006401) | 4.91569233 |
| 22 | chaperone-mediated protein transport (GO:0072321) | 4.45301380 |
| 23 | rRNA processing (GO:0006364) | 4.10406314 |
| 24 | cellular component biogenesis (GO:0044085) | 3.97252631 |
| 25 | rRNA metabolic process (GO:0016072) | 3.94966780 |
| 26 | * establishment of protein localization to membrane (GO:0090150) | 3.81901898 |
| 27 | formation of translation preinitiation complex (GO:0001731) | 3.64721860 |
| 28 | DNA deamination (GO:0045006) | 3.64640162 |
| 29 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.62893645 |
| 30 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.59572287 |
| 31 | * protein targeting (GO:0006605) | 3.56144546 |
| 32 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.54620276 |
| 33 | * establishment of protein localization to organelle (GO:0072594) | 3.54113112 |
| 34 | oxidative phosphorylation (GO:0006119) | 3.53413619 |
| 35 | ATP synthesis coupled proton transport (GO:0015986) | 3.43870347 |
| 36 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.43870347 |
| 37 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.42410169 |
| 38 | ncRNA 3-end processing (GO:0043628) | 3.41556423 |
| 39 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.34716934 |
| 40 | regulation of mitochondrial translation (GO:0070129) | 3.24095211 |
| 41 | DNA strand elongation (GO:0022616) | 3.23767696 |
| 42 | CENP-A containing nucleosome assembly (GO:0034080) | 3.17815719 |
| 43 | telomere maintenance via recombination (GO:0000722) | 3.17587832 |
| 44 | chromatin remodeling at centromere (GO:0031055) | 3.16608676 |
| 45 | spliceosomal snRNP assembly (GO:0000387) | 3.15819482 |
| 46 | spliceosomal complex assembly (GO:0000245) | 3.14254506 |
| 47 | termination of RNA polymerase III transcription (GO:0006386) | 3.07753628 |
| 48 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.07753628 |
| 49 | kinetochore organization (GO:0051383) | 3.07236426 |
| 50 | mitotic recombination (GO:0006312) | 3.01808017 |
| 51 | ATP biosynthetic process (GO:0006754) | 3.00190952 |
| 52 | protein targeting to mitochondrion (GO:0006626) | 2.99710902 |
| 53 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.97832056 |
| 54 | DNA replication initiation (GO:0006270) | 2.96993453 |
| 55 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.95857947 |
| 56 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.95857947 |
| 57 | NADH dehydrogenase complex assembly (GO:0010257) | 2.95857947 |
| 58 | protein complex biogenesis (GO:0070271) | 2.95753588 |
| 59 | * protein localization to membrane (GO:0072657) | 2.93953478 |
| 60 | negative regulation of RNA splicing (GO:0033119) | 2.92346195 |
| 61 | GTP biosynthetic process (GO:0006183) | 2.89942523 |
| 62 | proteasome assembly (GO:0043248) | 2.89212129 |
| 63 | establishment of integrated proviral latency (GO:0075713) | 2.85636902 |
| 64 | pyrimidine nucleotide catabolic process (GO:0006244) | 2.84868169 |
| 65 | pseudouridine synthesis (GO:0001522) | 2.84354319 |
| 66 | aerobic respiration (GO:0009060) | 2.83651867 |
| 67 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.83246382 |
| 68 | UTP biosynthetic process (GO:0006228) | 2.81678481 |
| 69 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.81198754 |
| 70 | DNA unwinding involved in DNA replication (GO:0006268) | 2.80905011 |
| 71 | telomere maintenance via telomere lengthening (GO:0010833) | 2.80855238 |
| 72 | kinetochore assembly (GO:0051382) | 2.79661311 |
| 73 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.79522466 |
| 74 | establishment of protein localization to mitochondrion (GO:0072655) | 2.79474261 |
| 75 | ncRNA processing (GO:0034470) | 2.76501174 |
| 76 | inner mitochondrial membrane organization (GO:0007007) | 2.75568124 |
| 77 | regulation of translational fidelity (GO:0006450) | 2.75425692 |
| 78 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.74295363 |
| 79 | * cellular component disassembly (GO:0022411) | 2.73747496 |
| 80 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.72642210 |
| 81 | DNA replication-independent nucleosome organization (GO:0034724) | 2.71929167 |
| 82 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.71929167 |
| 83 | histone mRNA metabolic process (GO:0008334) | 2.70821148 |
| 84 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.70465396 |
| 85 | protein localization to mitochondrion (GO:0070585) | 2.70171508 |
| 86 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 2.69826657 |
| 87 | DNA replication checkpoint (GO:0000076) | 2.68391272 |
| 88 | purine nucleobase biosynthetic process (GO:0009113) | 2.68103189 |
| 89 | * protein localization to organelle (GO:0033365) | 2.64653269 |
| 90 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.64627984 |
| 91 | ribonucleoprotein complex subunit organization (GO:0071826) | 2.63959444 |
| 92 | purine nucleoside monophosphate biosynthetic process (GO:0009127) | 2.62031149 |
| 93 | purine ribonucleoside monophosphate biosynthetic process (GO:0009168) | 2.62031149 |
| 94 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 2.61953287 |
| 95 | * gene expression (GO:0010467) | 2.60535333 |
| 96 | ribosome biogenesis (GO:0042254) | 2.60381116 |
| 97 | protein neddylation (GO:0045116) | 2.56744743 |
| 98 | heterochromatin organization (GO:0070828) | 2.53281097 |
| 99 | ncRNA metabolic process (GO:0034660) | 2.52751948 |
| 100 | nucleobase biosynthetic process (GO:0046112) | 2.51517977 |
| 101 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.51129496 |
| 102 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.51129496 |
| 103 | termination of RNA polymerase II transcription (GO:0006369) | 2.50487261 |
| 104 | termination of RNA polymerase I transcription (GO:0006363) | 2.50244178 |
| 105 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.50003967 |
| 106 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.49977334 |
| 107 | rRNA modification (GO:0000154) | 2.49300950 |
| 108 | mitotic chromosome condensation (GO:0007076) | 2.48381812 |
| 109 | DNA-templated transcription, termination (GO:0006353) | 2.45988289 |
| 110 | ribonucleoprotein complex assembly (GO:0022618) | 2.45474252 |
| 111 | protein localization to kinetochore (GO:0034501) | 2.41914975 |
| 112 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.41366214 |
| 113 | establishment of viral latency (GO:0019043) | 2.41294605 |
| 114 | RNA splicing, via transesterification reactions (GO:0000375) | 2.40803754 |
| 115 | respiratory electron transport chain (GO:0022904) | 2.40287530 |
| 116 | histone exchange (GO:0043486) | 2.40053587 |
| 117 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.40016430 |
| 118 | UTP metabolic process (GO:0046051) | 2.39741151 |
| 119 | mRNA splicing, via spliceosome (GO:0000398) | 2.39031956 |
| 120 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 2.39031956 |
| 121 | CTP biosynthetic process (GO:0006241) | 2.38186216 |
| 122 | CTP metabolic process (GO:0046036) | 2.38186216 |
| 123 | DNA damage response, detection of DNA damage (GO:0042769) | 2.38031914 |
| 124 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 2.35576339 |
| 125 | electron transport chain (GO:0022900) | 2.34992549 |
| 126 | transcription from RNA polymerase I promoter (GO:0006360) | 2.33943495 |
| 127 | DNA ligation (GO:0006266) | 2.33866531 |
| 128 | * viral transcription (GO:0019083) | 10.7236904 |
| 129 | * translational termination (GO:0006415) | 10.2996183 |
| 130 | ribosomal small subunit biogenesis (GO:0042274) | 10.0014844 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.61771125 |
| 2 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 5.09159126 |
| 3 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.65996450 |
| 4 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.69365430 |
| 5 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.68455833 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.54861669 |
| 7 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.49519393 |
| 8 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.36206487 |
| 9 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.33836197 |
| 10 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.07995282 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.93992460 |
| 12 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.90718538 |
| 13 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.87738873 |
| 14 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.85420477 |
| 15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.85282921 |
| 16 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.80341592 |
| 17 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.79433231 |
| 18 | * HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.62582106 |
| 19 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.60330166 |
| 20 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.50494330 |
| 21 | * TTF2_22483619_ChIP-Seq_HELA_Human | 2.46085030 |
| 22 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.40397346 |
| 23 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.39975836 |
| 24 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.32366929 |
| 25 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.27450167 |
| 26 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.26144229 |
| 27 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.24180091 |
| 28 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.14472463 |
| 29 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.14268711 |
| 30 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.10989819 |
| 31 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.06172394 |
| 32 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.99920789 |
| 33 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.97791041 |
| 34 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.91597502 |
| 35 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.84814821 |
| 36 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.84373876 |
| 37 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.70054130 |
| 38 | * ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.68849715 |
| 39 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.64997629 |
| 40 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.60317251 |
| 41 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.57694713 |
| 42 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.54282687 |
| 43 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.53446237 |
| 44 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.49478756 |
| 45 | * KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.48594965 |
| 46 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.47587853 |
| 47 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.47317028 |
| 48 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.46657716 |
| 49 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.46126662 |
| 50 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.44091098 |
| 51 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.43815687 |
| 52 | * THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.42724906 |
| 53 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.41072224 |
| 54 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.38669841 |
| 55 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.37725218 |
| 56 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.36976695 |
| 57 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.34926185 |
| 58 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.32215992 |
| 59 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.30225523 |
| 60 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.27509180 |
| 61 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.25157571 |
| 62 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.22690265 |
| 63 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.22690265 |
| 64 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.22690265 |
| 65 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.22437986 |
| 66 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.20393119 |
| 67 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.18153698 |
| 68 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.16488028 |
| 69 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.16329582 |
| 70 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.15739290 |
| 71 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.14176337 |
| 72 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.12086596 |
| 73 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.11104676 |
| 74 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.10240371 |
| 75 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.09677875 |
| 76 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.06972383 |
| 77 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.06652297 |
| 78 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.06458830 |
| 79 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.05897572 |
| 80 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.04406614 |
| 81 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.04226408 |
| 82 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.03016714 |
| 83 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.99739325 |
| 84 | MYC_22102868_ChIP-Seq_BL_Human | 0.99665695 |
| 85 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.99639191 |
| 86 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.99625752 |
| 87 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.99439804 |
| 88 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.96440595 |
| 89 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.96425359 |
| 90 | * SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.95903395 |
| 91 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.93077502 |
| 92 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.92216361 |
| 93 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.91938124 |
| 94 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.91062269 |
| 95 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.90630672 |
| 96 | * SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.90436291 |
| 97 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.90277965 |
| 98 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.89009456 |
| 99 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.88700290 |
| 100 | * TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.88160906 |
| 101 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.87569291 |
| 102 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.86447418 |
| 103 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.86231499 |
| 104 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.85488449 |
| 105 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.85039983 |
| 106 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.84797376 |
| 107 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.84750979 |
| 108 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.83097149 |
| 109 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.83011497 |
| 110 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.81590057 |
| 111 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.81409112 |
| 112 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.81108210 |
| 113 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.79606669 |
| 114 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.77791570 |
| 115 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.75856959 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0009379_abnormal_foot_pigmentation | 7.42753292 |
| 2 | MP0003693_abnormal_embryo_hatching | 3.69372816 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 3.49830842 |
| 4 | MP0010094_abnormal_chromosome_stability | 2.95903190 |
| 5 | MP0008057_abnormal_DNA_replication | 2.72764753 |
| 6 | MP0003077_abnormal_cell_cycle | 2.66878337 |
| 7 | MP0003111_abnormal_nucleus_morphology | 2.39781420 |
| 8 | MP0003136_yellow_coat_color | 2.23931302 |
| 9 | MP0008007_abnormal_cellular_replicative | 2.14338728 |
| 10 | MP0008058_abnormal_DNA_repair | 2.12669776 |
| 11 | MP0008932_abnormal_embryonic_tissue | 2.10996477 |
| 12 | MP0003941_abnormal_skin_development | 1.97637582 |
| 13 | MP0002396_abnormal_hematopoietic_system | 1.89861234 |
| 14 | MP0000490_abnormal_crypts_of | 1.88727744 |
| 15 | MP0004381_abnormal_hair_follicle | 1.86787952 |
| 16 | MP0005174_abnormal_tail_pigmentation | 1.82908385 |
| 17 | MP0003763_abnormal_thymus_physiology | 1.82545532 |
| 18 | MP0008789_abnormal_olfactory_epithelium | 1.79300850 |
| 19 | MP0003786_premature_aging | 1.76227957 |
| 20 | MP0009333_abnormal_splenocyte_physiolog | 1.62217104 |
| 21 | MP0000566_synostosis | 1.54386298 |
| 22 | MP0002095_abnormal_skin_pigmentation | 1.47784747 |
| 23 | MP0002132_abnormal_respiratory_system | 1.46239004 |
| 24 | MP0005499_abnormal_olfactory_system | 1.41387346 |
| 25 | MP0005394_taste/olfaction_phenotype | 1.41387346 |
| 26 | MP0000350_abnormal_cell_proliferation | 1.40402082 |
| 27 | MP0001286_abnormal_eye_development | 1.39405763 |
| 28 | MP0002166_altered_tumor_susceptibility | 1.38594947 |
| 29 | MP0001346_abnormal_lacrimal_gland | 1.36819549 |
| 30 | MP0002009_preneoplasia | 1.34812134 |
| 31 | MP0002697_abnormal_eye_size | 1.32137779 |
| 32 | MP0006036_abnormal_mitochondrial_physio | 1.31723968 |
| 33 | MP0003890_abnormal_embryonic-extraembry | 1.31630436 |
| 34 | MP0002938_white_spotting | 1.28763482 |
| 35 | MP0002160_abnormal_reproductive_system | 1.24674659 |
| 36 | MP0002006_tumorigenesis | 1.24176279 |
| 37 | MP0003806_abnormal_nucleotide_metabolis | 1.23996876 |
| 38 | MP0002163_abnormal_gland_morphology | 1.23137311 |
| 39 | MP0002277_abnormal_respiratory_mucosa | 1.22558677 |
| 40 | MP0001800_abnormal_humoral_immune | 1.21423066 |
| 41 | MP0003315_abnormal_perineum_morphology | 1.21227773 |
| 42 | MP0002398_abnormal_bone_marrow | 1.20145563 |
| 43 | MP0000703_abnormal_thymus_morphology | 1.20002467 |
| 44 | MP0002148_abnormal_hypersensitivity_rea | 1.19402391 |
| 45 | MP0001835_abnormal_antigen_presentation | 1.19164124 |
| 46 | MP0003724_increased_susceptibility_to | 1.18027168 |
| 47 | MP0003123_paternal_imprinting | 1.17872335 |
| 48 | MP0000858_altered_metastatic_potential | 1.15707113 |
| 49 | MP0002210_abnormal_sex_determination | 1.15364637 |
| 50 | MP0002102_abnormal_ear_morphology | 1.14952610 |
| 51 | MP0004808_abnormal_hematopoietic_stem | 1.14938341 |
| 52 | MP0002722_abnormal_immune_system | 1.12701050 |
| 53 | MP0002019_abnormal_tumor_incidence | 1.12410773 |
| 54 | MP0003567_abnormal_fetal_cardiomyocyte | 1.11127881 |
| 55 | MP0005501_abnormal_skin_physiology | 1.10499488 |
| 56 | MP0000372_irregular_coat_pigmentation | 1.10318673 |
| 57 | MP0005671_abnormal_response_to | 1.09511664 |
| 58 | MP0001730_embryonic_growth_arrest | 1.08032141 |
| 59 | MP0003984_embryonic_growth_retardation | 1.07804286 |
| 60 | MP0002420_abnormal_adaptive_immunity | 1.06858310 |
| 61 | MP0009697_abnormal_copulation | 1.06393919 |
| 62 | MP0006072_abnormal_retinal_apoptosis | 1.06003517 |
| 63 | MP0002452_abnormal_antigen_presenting | 1.04446455 |
| 64 | MP0001819_abnormal_immune_cell | 1.04408236 |
| 65 | MP0006292_abnormal_olfactory_placode | 1.04099141 |
| 66 | MP0003937_abnormal_limbs/digits/tail_de | 1.03676332 |
| 67 | MP0002088_abnormal_embryonic_growth/wei | 1.02297261 |
| 68 | MP0000685_abnormal_immune_system | 1.02289010 |
| 69 | MP0002796_impaired_skin_barrier | 1.02142218 |
| 70 | MP0005075_abnormal_melanosome_morpholog | 1.02018053 |
| 71 | MP0005000_abnormal_immune_tolerance | 1.01894922 |
| 72 | MP0009785_altered_susceptibility_to | 1.01275688 |
| 73 | MP0001853_heart_inflammation | 1.00779381 |
| 74 | MP0000689_abnormal_spleen_morphology | 1.00742259 |
| 75 | MP0010030_abnormal_orbit_morphology | 1.00104703 |
| 76 | MP0002084_abnormal_developmental_patter | 0.99586908 |
| 77 | MP0000313_abnormal_cell_death | 0.99569335 |
| 78 | MP0006035_abnormal_mitochondrial_morpho | 0.99534862 |
| 79 | MP0010352_gastrointestinal_tract_polyps | 0.98731885 |
| 80 | MP0000465_gastrointestinal_hemorrhage | 0.97885405 |
| 81 | MP0000631_abnormal_neuroendocrine_gland | 0.97375370 |
| 82 | MP0002723_abnormal_immune_serum | 0.96818532 |
| 83 | MP0002429_abnormal_blood_cell | 0.96605085 |
| 84 | MP0000716_abnormal_immune_system | 0.96506737 |
| 85 | MP0002405_respiratory_system_inflammati | 0.96416973 |
| 86 | MP0005025_abnormal_response_to | 0.95768318 |
| 87 | MP0000537_abnormal_urethra_morphology | 0.94491635 |
| 88 | MP0002233_abnormal_nose_morphology | 0.94163851 |
| 89 | MP0001145_abnormal_male_reproductive | 0.93457758 |
| 90 | MP0001529_abnormal_vocalization | 0.91579021 |
| 91 | MP0010155_abnormal_intestine_physiology | 0.91241817 |
| 92 | MP0002092_abnormal_eye_morphology | 0.90526727 |
| 93 | MP0003436_decreased_susceptibility_to | 0.90175925 |
| 94 | MP0005408_hypopigmentation | 0.89993638 |
| 95 | MP0002249_abnormal_larynx_morphology | 0.89919798 |
| 96 | MP0001986_abnormal_taste_sensitivity | 0.89827195 |
| 97 | MP0001697_abnormal_embryo_size | 0.89481386 |
| 98 | MP0001881_abnormal_mammary_gland | 0.86982712 |
| 99 | MP0003186_abnormal_redox_activity | 0.85861940 |
| 100 | MP0002098_abnormal_vibrissa_morphology | 0.85741417 |
| 101 | MP0002638_abnormal_pupillary_reflex | 0.84527430 |
| 102 | MP0002080_prenatal_lethality | 0.84054241 |
| 103 | MP0003866_abnormal_defecation | 0.83941136 |
| 104 | MP0009250_abnormal_appendicular_skeleto | 0.83382686 |
| 105 | MP0003718_maternal_effect | 0.82943255 |
| 106 | MP0001545_abnormal_hematopoietic_system | 0.81520465 |
| 107 | MP0005397_hematopoietic_system_phenotyp | 0.81520465 |
| 108 | MP0006054_spinal_hemorrhage | 0.81459694 |
| 109 | MP0002234_abnormal_pharynx_morphology | 0.80686238 |
| 110 | MP0005389_reproductive_system_phenotype | 0.80042957 |
| 111 | MP0002282_abnormal_trachea_morphology | 0.79624198 |
| 112 | MP0000653_abnormal_sex_gland | 0.78992690 |
| 113 | MP0004147_increased_porphyrin_level | 0.78817767 |
| 114 | MP0001216_abnormal_epidermal_layer | 0.78717046 |
| 115 | MP0001929_abnormal_gametogenesis | 0.78607438 |
| 116 | MP0002111_abnormal_tail_morphology | 0.78200261 |
| 117 | MP0000049_abnormal_middle_ear | 0.77792890 |
| 118 | MP0000762_abnormal_tongue_morphology | 0.77533755 |
| 119 | MP0003453_abnormal_keratinocyte_physiol | 0.76563208 |
| 120 | MP0005409_darkened_coat_color | 0.76554292 |
| 121 | MP0002085_abnormal_embryonic_tissue | 0.76412414 |
| 122 | MP0008877_abnormal_DNA_methylation | 0.75648236 |
| 123 | MP0003938_abnormal_ear_development | 0.74525245 |
| 124 | MP0001873_stomach_inflammation | 0.73901591 |
| 125 | MP0003385_abnormal_body_wall | 0.73446263 |
| 126 | MP0009672_abnormal_birth_weight | 0.73306614 |
| 127 | MP0003448_altered_tumor_morphology | 0.73299809 |
| 128 | MP0000613_abnormal_salivary_gland | 0.72921716 |
| 129 | MP0002060_abnormal_skin_morphology | 0.72783918 |
| 130 | MP0009053_abnormal_anal_canal | 0.71683239 |
| 131 | MP0004142_abnormal_muscle_tone | 0.70187450 |
| 132 | MP0008995_early_reproductive_senescence | 0.70050232 |
| 133 | MP0001293_anophthalmia | 0.69886591 |
| 134 | MP0003303_peritoneal_inflammation | 0.69448706 |
| 135 | MP0005387_immune_system_phenotype | 0.69439114 |
| 136 | MP0001790_abnormal_immune_system | 0.69439114 |
| 137 | MP0005380_embryogenesis_phenotype | 0.68910817 |
| 138 | MP0001672_abnormal_embryogenesis/_devel | 0.68910817 |
| 139 | MP0003828_pulmonary_edema | 0.68895974 |
| 140 | MP0004185_abnormal_adipocyte_glucose | 0.67753025 |
| 141 | MP0000428_abnormal_craniofacial_morphol | 0.67200246 |
| 142 | MP0005391_vision/eye_phenotype | 0.63105064 |
| 143 | MP0003942_abnormal_urinary_system | 0.62516937 |
| 144 | MP0003121_genomic_imprinting | 0.60902834 |
| 145 | MP0003861_abnormal_nervous_system | 0.60133263 |
| 146 | MP0000358_abnormal_cell_content/ | 0.59715452 |
| 147 | MP0001919_abnormal_reproductive_system | 0.59514024 |
| 148 | MP0001119_abnormal_female_reproductive | 0.59433510 |
| 149 | MP0001188_hyperpigmentation | 0.59269134 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 9.09886464 |
| 2 | Reticulocytopenia (HP:0001896) | 8.97607078 |
| 3 | Abnormal number of erythroid precursors (HP:0012131) | 8.27345236 |
| 4 | Macrocytic anemia (HP:0001972) | 6.82514192 |
| 5 | Pallor (HP:0000980) | 6.31705834 |
| 6 | Abnormal hemoglobin (HP:0011902) | 4.89442447 |
| 7 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 4.11853413 |
| 8 | Increased hepatocellular lipid droplets (HP:0006565) | 3.33676664 |
| 9 | Colon cancer (HP:0003003) | 3.33509613 |
| 10 | Congenital, generalized hypertrichosis (HP:0004540) | 3.22691808 |
| 11 | Thrombocytosis (HP:0001894) | 3.20728073 |
| 12 | Acute necrotizing encephalopathy (HP:0006965) | 3.13013245 |
| 13 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.10414616 |
| 14 | Absent thumb (HP:0009777) | 3.07394443 |
| 15 | Mitochondrial inheritance (HP:0001427) | 3.06763292 |
| 16 | Depressed nasal ridge (HP:0000457) | 3.01033716 |
| 17 | Aplastic anemia (HP:0001915) | 2.98627428 |
| 18 | 11 pairs of ribs (HP:0000878) | 2.95719368 |
| 19 | Abnormality of reticulocytes (HP:0004312) | 2.90803032 |
| 20 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.90497958 |
| 21 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.90497958 |
| 22 | Exertional dyspnea (HP:0002875) | 2.79245381 |
| 23 | Cerebral edema (HP:0002181) | 2.78336865 |
| 24 | Lipid accumulation in hepatocytes (HP:0006561) | 2.78177513 |
| 25 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.72625082 |
| 26 | Trismus (HP:0000211) | 2.72100387 |
| 27 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.70095624 |
| 28 | Triphalangeal thumb (HP:0001199) | 2.69750724 |
| 29 | Septo-optic dysplasia (HP:0100842) | 2.64832300 |
| 30 | Progressive macrocephaly (HP:0004481) | 2.60197412 |
| 31 | Hepatocellular necrosis (HP:0001404) | 2.59886334 |
| 32 | Increased CSF lactate (HP:0002490) | 2.53516738 |
| 33 | Oral leukoplakia (HP:0002745) | 2.50838034 |
| 34 | Breast hypoplasia (HP:0003187) | 2.43174807 |
| 35 | Migraine (HP:0002076) | 2.42336761 |
| 36 | Thick lower lip vermilion (HP:0000179) | 2.41320485 |
| 37 | Abnormality of the parietal bone (HP:0002696) | 2.39120078 |
| 38 | Woolly hair (HP:0002224) | 2.37680300 |
| 39 | 3-Methylglutaconic aciduria (HP:0003535) | 2.37538992 |
| 40 | Renal Fanconi syndrome (HP:0001994) | 2.37328997 |
| 41 | Lactic acidosis (HP:0003128) | 2.27011931 |
| 42 | Acute encephalopathy (HP:0006846) | 2.26420217 |
| 43 | Stenosis of the external auditory canal (HP:0000402) | 2.26292539 |
| 44 | Respiratory difficulties (HP:0002880) | 2.25317632 |
| 45 | Hypoplasia of the radius (HP:0002984) | 2.21886735 |
| 46 | Increased intramyocellular lipid droplets (HP:0012240) | 2.19849331 |
| 47 | Multiple enchondromatosis (HP:0005701) | 2.18381981 |
| 48 | Asplenia (HP:0001746) | 2.17971270 |
| 49 | Leukodystrophy (HP:0002415) | 2.17535078 |
| 50 | Abnormality of secondary sexual hair (HP:0009888) | 2.17334219 |
| 51 | Abnormality of the axillary hair (HP:0100134) | 2.17334219 |
| 52 | Partial duplication of the phalanx of hand (HP:0009999) | 2.14425288 |
| 53 | Rough bone trabeculation (HP:0100670) | 2.12793910 |
| 54 | Concave nail (HP:0001598) | 2.10561901 |
| 55 | Maternal diabetes (HP:0009800) | 2.10220185 |
| 56 | Short middle phalanx of the 5th finger (HP:0004220) | 2.09309485 |
| 57 | Abnormality of the preputium (HP:0100587) | 2.08885896 |
| 58 | Cleft eyelid (HP:0000625) | 2.07860082 |
| 59 | Hepatic necrosis (HP:0002605) | 2.07318966 |
| 60 | Birth length less than 3rd percentile (HP:0003561) | 2.04717465 |
| 61 | Partial duplication of thumb phalanx (HP:0009944) | 2.04411979 |
| 62 | IgM deficiency (HP:0002850) | 2.02506513 |
| 63 | Sparse eyelashes (HP:0000653) | 2.01038588 |
| 64 | Abnormality of renal resorption (HP:0011038) | 2.00839963 |
| 65 | Exercise intolerance (HP:0003546) | 1.97079375 |
| 66 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.96543741 |
| 67 | Absent septum pellucidum (HP:0001331) | 1.95998136 |
| 68 | Glossoptosis (HP:0000162) | 1.95070314 |
| 69 | Chromsome breakage (HP:0040012) | 1.93702767 |
| 70 | Myelodysplasia (HP:0002863) | 1.92878261 |
| 71 | Increased serum lactate (HP:0002151) | 1.92358018 |
| 72 | Rib fusion (HP:0000902) | 1.89054962 |
| 73 | Microvesicular hepatic steatosis (HP:0001414) | 1.88743868 |
| 74 | Premature graying of hair (HP:0002216) | 1.87898520 |
| 75 | Abnormality of the septum pellucidum (HP:0007375) | 1.87786435 |
| 76 | Progressive muscle weakness (HP:0003323) | 1.85767109 |
| 77 | Sparse lateral eyebrow (HP:0005338) | 1.84378656 |
| 78 | Atresia of the external auditory canal (HP:0000413) | 1.82745007 |
| 79 | Horseshoe kidney (HP:0000085) | 1.81708708 |
| 80 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.81319700 |
| 81 | Meckel diverticulum (HP:0002245) | 1.80927651 |
| 82 | Missing ribs (HP:0000921) | 1.79886757 |
| 83 | Selective tooth agenesis (HP:0001592) | 1.79569872 |
| 84 | Duplicated collecting system (HP:0000081) | 1.79054416 |
| 85 | Nasolacrimal duct obstruction (HP:0000579) | 1.78496162 |
| 86 | Absent radius (HP:0003974) | 1.77132761 |
| 87 | Abnormality of cochlea (HP:0000375) | 1.75967603 |
| 88 | Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376) | 1.75031945 |
| 89 | Cellular immunodeficiency (HP:0005374) | 1.74183260 |
| 90 | Secondary amenorrhea (HP:0000869) | 1.73454854 |
| 91 | Abnormality of the ileum (HP:0001549) | 1.71932043 |
| 92 | Respiratory failure (HP:0002878) | 1.71634559 |
| 93 | Pancytopenia (HP:0001876) | 1.70637822 |
| 94 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.69308704 |
| 95 | Increased muscle lipid content (HP:0009058) | 1.68356685 |
| 96 | Abnormality of chromosome stability (HP:0003220) | 1.66997044 |
| 97 | Hyperphosphaturia (HP:0003109) | 1.66626297 |
| 98 | Parakeratosis (HP:0001036) | 1.65955657 |
| 99 | Abnormal number of incisors (HP:0011064) | 1.65188890 |
| 100 | Facial cleft (HP:0002006) | 1.63492688 |
| 101 | Type I transferrin isoform profile (HP:0003642) | 1.63125383 |
| 102 | Abdominal situs inversus (HP:0003363) | 1.62970932 |
| 103 | Abnormality of abdominal situs (HP:0011620) | 1.62970932 |
| 104 | Aplasia involving forearm bones (HP:0009822) | 1.62536199 |
| 105 | Absent forearm bone (HP:0003953) | 1.62536199 |
| 106 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 1.61878318 |
| 107 | Patellar aplasia (HP:0006443) | 1.61292844 |
| 108 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 1.60843259 |
| 109 | Neoplasm of the pancreas (HP:0002894) | 1.60656541 |
| 110 | Megaloblastic anemia (HP:0001889) | 1.60545356 |
| 111 | Optic disc pallor (HP:0000543) | 1.59999839 |
| 112 | Duplication of thumb phalanx (HP:0009942) | 1.59490763 |
| 113 | Abnormality of the lacrimal duct (HP:0011481) | 1.59446654 |
| 114 | Microretrognathia (HP:0000308) | 1.58894786 |
| 115 | Abnormal lung lobation (HP:0002101) | 1.57502617 |
| 116 | Lymphoma (HP:0002665) | 1.57454777 |
| 117 | Poikiloderma (HP:0001029) | 1.56398748 |
| 118 | Abnormal trabecular bone morphology (HP:0100671) | 1.55433515 |
| 119 | Sensory axonal neuropathy (HP:0003390) | 1.54507670 |
| 120 | Fragile nails (HP:0001808) | 1.54021783 |
| 121 | Abnormality of methionine metabolism (HP:0010901) | 1.53642463 |
| 122 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.52064277 |
| 123 | Bilateral microphthalmos (HP:0007633) | 1.51929734 |
| 124 | Abnormality of placental membranes (HP:0011409) | 1.51865638 |
| 125 | Amniotic constriction ring (HP:0009775) | 1.51865638 |
| 126 | Supernumerary spleens (HP:0009799) | 1.50872805 |
| 127 | Abnormality of the nasolacrimal system (HP:0000614) | 1.50358346 |
| 128 | Tracheoesophageal fistula (HP:0002575) | 1.50098764 |
| 129 | Muscle fiber atrophy (HP:0100295) | 1.49920262 |
| 130 | Increased serum pyruvate (HP:0003542) | 1.49875035 |
| 131 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 1.49402801 |
| 132 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 1.49015180 |
| 133 | Abnormality of homocysteine metabolism (HP:0010919) | 1.45865459 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NME2 | 5.79616595 |
| 2 | VRK2 | 4.50974889 |
| 3 | TLK1 | 4.25955190 |
| 4 | EIF2AK1 | 3.49820434 |
| 5 | BUB1 | 3.22434944 |
| 6 | WEE1 | 3.02782736 |
| 7 | MST4 | 2.56416459 |
| 8 | MAP3K10 | 2.53826495 |
| 9 | VRK1 | 2.47576441 |
| 10 | SRPK1 | 2.46999124 |
| 11 | STK16 | 2.34145125 |
| 12 | RPS6KB2 | 2.33844053 |
| 13 | CDC7 | 1.94754363 |
| 14 | NEK1 | 1.92555835 |
| 15 | PIM2 | 1.89485509 |
| 16 | TAF1 | 1.85199201 |
| 17 | DYRK3 | 1.84368463 |
| 18 | EIF2AK3 | 1.81471192 |
| 19 | PBK | 1.69216117 |
| 20 | LRRK2 | 1.66752688 |
| 21 | RPS6KA4 | 1.55985176 |
| 22 | TGFBR1 | 1.52562932 |
| 23 | AURKB | 1.50916108 |
| 24 | TEC | 1.47540205 |
| 25 | TSSK6 | 1.46963347 |
| 26 | MKNK1 | 1.46442170 |
| 27 | PASK | 1.41278997 |
| 28 | ACVR1B | 1.36939947 |
| 29 | TESK2 | 1.36005689 |
| 30 | MAP4K1 | 1.34407230 |
| 31 | CDK7 | 1.32754311 |
| 32 | NME1 | 1.20581672 |
| 33 | NEK2 | 1.20354266 |
| 34 | PLK1 | 1.18464147 |
| 35 | BRSK2 | 1.17202189 |
| 36 | SMG1 | 1.12278955 |
| 37 | EEF2K | 1.05670952 |
| 38 | PIM1 | 1.03908921 |
| 39 | STK10 | 1.03905014 |
| 40 | RPS6KA5 | 1.03005133 |
| 41 | IRAK4 | 0.99997470 |
| 42 | MKNK2 | 0.99287678 |
| 43 | AURKA | 0.95103314 |
| 44 | EIF2AK2 | 0.91356934 |
| 45 | BTK | 0.90403255 |
| 46 | TTK | 0.90237901 |
| 47 | NLK | 0.88524308 |
| 48 | CLK1 | 0.87354957 |
| 49 | ILK | 0.86955581 |
| 50 | CSNK2A2 | 0.85585254 |
| 51 | CDK19 | 0.84527569 |
| 52 | FLT3 | 0.83061941 |
| 53 | ATR | 0.82940310 |
| 54 | MAPKAPK3 | 0.80383413 |
| 55 | CDK8 | 0.80228718 |
| 56 | BLK | 0.79471181 |
| 57 | STK24 | 0.79361549 |
| 58 | BCKDK | 0.77385869 |
| 59 | IRAK3 | 0.76681960 |
| 60 | TXK | 0.74890363 |
| 61 | IKBKB | 0.74777996 |
| 62 | BRAF | 0.74282308 |
| 63 | PLK4 | 0.73673029 |
| 64 | CSNK2A1 | 0.72903490 |
| 65 | MAP3K8 | 0.70713103 |
| 66 | BRSK1 | 0.70286570 |
| 67 | PRKD2 | 0.70210189 |
| 68 | MAP2K2 | 0.69844524 |
| 69 | STK4 | 0.69463104 |
| 70 | PAK4 | 0.66288497 |
| 71 | BMPR1B | 0.64115603 |
| 72 | GRK6 | 0.63716061 |
| 73 | CDK4 | 0.63402765 |
| 74 | EPHB2 | 0.62642398 |
| 75 | CHEK2 | 0.61143849 |
| 76 | CDK3 | 0.61035699 |
| 77 | KDR | 0.60421243 |
| 78 | CCNB1 | 0.59330365 |
| 79 | KIT | 0.58578888 |
| 80 | FES | 0.58274306 |
| 81 | DYRK1B | 0.58267518 |
| 82 | MAPKAPK5 | 0.57805742 |
| 83 | LCK | 0.56601325 |
| 84 | DYRK2 | 0.56326281 |
| 85 | YES1 | 0.56283309 |
| 86 | CDK9 | 0.55334895 |
| 87 | STK3 | 0.55228706 |
| 88 | PAK1 | 0.55177924 |
| 89 | CHEK1 | 0.54310993 |
| 90 | LYN | 0.54016703 |
| 91 | PDK2 | 0.52807037 |
| 92 | ARAF | 0.52254115 |
| 93 | CSNK1E | 0.51586681 |
| 94 | MAP3K11 | 0.51553416 |
| 95 | TYK2 | 0.51456107 |
| 96 | CDK6 | 0.50887987 |
| 97 | CDK1 | 0.50863541 |
| 98 | PLK3 | 0.49521220 |
| 99 | ATM | 0.47495550 |
| 100 | EPHA2 | 0.45193423 |
| 101 | DAPK3 | 0.45158588 |
| 102 | ZAK | 0.44927806 |
| 103 | PAK2 | 0.44437030 |
| 104 | MAP3K12 | 0.43900451 |
| 105 | ZAP70 | 0.43604497 |
| 106 | ADRBK1 | 0.42822380 |
| 107 | NEK9 | 0.42340081 |
| 108 | ALK | 0.40879059 |
| 109 | NUAK1 | 0.40867969 |
| 110 | IKBKE | 0.40758194 |
| 111 | PRPF4B | 0.40531920 |
| 112 | ITK | 0.40187162 |
| 113 | TESK1 | 0.40150328 |
| 114 | PNCK | 0.38255881 |
| 115 | CDK11A | 0.37291900 |
| 116 | MAPK15 | 0.36014467 |
| 117 | RPS6KC1 | 0.34880742 |
| 118 | RPS6KL1 | 0.34880742 |
| 119 | CDK2 | 0.34865869 |
| 120 | CSK | 0.34722198 |
| 121 | MOS | 0.34397554 |
| 122 | MAP3K3 | 0.34282202 |
| 123 | MST1R | 0.34265649 |
| 124 | SCYL2 | 0.34217155 |
| 125 | AKT2 | 0.33171519 |
| 126 | RPS6KA6 | 0.32477264 |
| 127 | MARK3 | 0.27795319 |
| 128 | PRKDC | 0.27099364 |
| 129 | RPS6KA1 | 0.25326307 |
| 130 | FGFR1 | 0.25024780 |
| 131 | AKT1 | 0.24537883 |
| 132 | ABL2 | 0.23679608 |
| 133 | TYRO3 | 0.22120472 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * Ribosome_Homo sapiens_hsa03010 | 8.16132089 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 3.62225003 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 3.16790342 |
| 4 | Mismatch repair_Homo sapiens_hsa03430 | 3.09924821 |
| 5 | Spliceosome_Homo sapiens_hsa03040 | 3.01561439 |
| 6 | Proteasome_Homo sapiens_hsa03050 | 2.86706464 |
| 7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.55508858 |
| 8 | Homologous recombination_Homo sapiens_hsa03440 | 2.50738217 |
| 9 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.34239884 |
| 10 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.33734940 |
| 11 | Parkinsons disease_Homo sapiens_hsa05012 | 2.22242059 |
| 12 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.17444909 |
| 13 | Protein export_Homo sapiens_hsa03060 | 2.16584932 |
| 14 | RNA transport_Homo sapiens_hsa03013 | 2.00341557 |
| 15 | Base excision repair_Homo sapiens_hsa03410 | 1.96710675 |
| 16 | Huntingtons disease_Homo sapiens_hsa05016 | 1.80447259 |
| 17 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.73560856 |
| 18 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.69709513 |
| 19 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.59447848 |
| 20 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.57811095 |
| 21 | Basal transcription factors_Homo sapiens_hsa03022 | 1.56791418 |
| 22 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.53201757 |
| 23 | Cell cycle_Homo sapiens_hsa04110 | 1.48662895 |
| 24 | RNA degradation_Homo sapiens_hsa03018 | 1.45645342 |
| 25 | Alzheimers disease_Homo sapiens_hsa05010 | 1.45131022 |
| 26 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.43300551 |
| 27 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.24038044 |
| 28 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.22522412 |
| 29 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.19585835 |
| 30 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.12003664 |
| 31 | Purine metabolism_Homo sapiens_hsa00230 | 1.03350742 |
| 32 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.00133565 |
| 33 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.00023087 |
| 34 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.91461670 |
| 35 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.82274550 |
| 36 | Sulfur relay system_Homo sapiens_hsa04122 | 0.81133063 |
| 37 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.79395734 |
| 38 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.77223771 |
| 39 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.73981488 |
| 40 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.73063196 |
| 41 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.71675461 |
| 42 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.66992870 |
| 43 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.64108621 |
| 44 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.63475899 |
| 45 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.63095253 |
| 46 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.62300009 |
| 47 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.61613014 |
| 48 | Alcoholism_Homo sapiens_hsa05034 | 0.60988240 |
| 49 | Measles_Homo sapiens_hsa05162 | 0.60230220 |
| 50 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.57929340 |
| 51 | Carbon metabolism_Homo sapiens_hsa01200 | 0.57711802 |
| 52 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.56804574 |
| 53 | Thyroid cancer_Homo sapiens_hsa05216 | 0.56302366 |
| 54 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.53444288 |
| 55 | Allograft rejection_Homo sapiens_hsa05330 | 0.52625212 |
| 56 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.52037328 |
| 57 | Legionellosis_Homo sapiens_hsa05134 | 0.52025473 |
| 58 | HTLV-I infection_Homo sapiens_hsa05166 | 0.51178322 |
| 59 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.51123666 |
| 60 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.50531099 |
| 61 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.50339443 |
| 62 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.50253193 |
| 63 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.48126286 |
| 64 | Asthma_Homo sapiens_hsa05310 | 0.45944542 |
| 65 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.43990455 |
| 66 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.43895308 |
| 67 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.43036526 |
| 68 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.42511449 |
| 69 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.41556278 |
| 70 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.40410563 |
| 71 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.39131668 |
| 72 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.38303767 |
| 73 | Apoptosis_Homo sapiens_hsa04210 | 0.37771246 |
| 74 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.36867288 |
| 75 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.35983115 |
| 76 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.35455666 |
| 77 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.33515630 |
| 78 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.33293368 |
| 79 | Hepatitis B_Homo sapiens_hsa05161 | 0.31132531 |
| 80 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.29525475 |
| 81 | Malaria_Homo sapiens_hsa05144 | 0.29433311 |
| 82 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.29372396 |
| 83 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.28062566 |
| 84 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.28004077 |
| 85 | Leishmaniasis_Homo sapiens_hsa05140 | 0.27198280 |
| 86 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.26587633 |
| 87 | Pathways in cancer_Homo sapiens_hsa05200 | 0.25990157 |
| 88 | Viral myocarditis_Homo sapiens_hsa05416 | 0.25832613 |
| 89 | Metabolic pathways_Homo sapiens_hsa01100 | 0.25231463 |
| 90 | Shigellosis_Homo sapiens_hsa05131 | 0.24972285 |
| 91 | Other glycan degradation_Homo sapiens_hsa00511 | 0.24707959 |
| 92 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.24530063 |
| 93 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.22594981 |
| 94 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.22109493 |
| 95 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.22053711 |
| 96 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.21840502 |
| 97 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.21210887 |
| 98 | Influenza A_Homo sapiens_hsa05164 | 0.20602376 |
| 99 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.20193482 |
| 100 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.19455542 |
| 101 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.19202590 |
| 102 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.18804899 |
| 103 | Bladder cancer_Homo sapiens_hsa05219 | 0.18794122 |
| 104 | Colorectal cancer_Homo sapiens_hsa05210 | 0.16983440 |
| 105 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.16886060 |
| 106 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.16552143 |
| 107 | Pertussis_Homo sapiens_hsa05133 | 0.16519717 |
| 108 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.15279883 |
| 109 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.14495476 |
| 110 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.12848067 |
| 111 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.12827927 |
| 112 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.12513744 |
| 113 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.11931946 |
| 114 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.11926441 |
| 115 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.11764693 |
| 116 | Prostate cancer_Homo sapiens_hsa05215 | 0.11435657 |
| 117 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.10917454 |
| 118 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.10894769 |
| 119 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.10616209 |
| 120 | Peroxisome_Homo sapiens_hsa04146 | 0.06034167 |
| 121 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.04584109 |
| 122 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.04368094 |
| 123 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.02692396 |
| 124 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.02347823 |
| 125 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.02187448 |
| 126 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.02007166 |
| 127 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.01604147 |
| 128 | Pancreatic cancer_Homo sapiens_hsa05212 | -0.0484734 |
| 129 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | -0.0402070 |
| 130 | Non-small cell lung cancer_Homo sapiens_hsa05223 | -0.0153785 |

