RPS23P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.13737620
2viral transcription (GO:0019083)5.78154938
3translational termination (GO:0006415)5.66234266
4maturation of SSU-rRNA (GO:0030490)5.43871305
5ribosomal small subunit biogenesis (GO:0042274)5.19756686
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.87869980
7cotranslational protein targeting to membrane (GO:0006613)4.81378303
8protein targeting to ER (GO:0045047)4.76733114
9translational elongation (GO:0006414)4.67564104
10establishment of protein localization to endoplasmic reticulum (GO:0072599)4.56578010
11protein localization to endoplasmic reticulum (GO:0070972)4.51219976
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.46707768
13ATP synthesis coupled proton transport (GO:0015986)4.46707768
14behavioral response to nicotine (GO:0035095)4.44692532
15response to pheromone (GO:0019236)4.44632649
16chaperone-mediated protein transport (GO:0072321)4.36175954
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.35831226
18viral life cycle (GO:0019058)4.21379123
19cellular protein complex disassembly (GO:0043624)4.16757853
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.09311341
21protein neddylation (GO:0045116)4.03585256
22protein complex biogenesis (GO:0070271)3.92272023
23auditory receptor cell differentiation (GO:0042491)3.91885174
24translational initiation (GO:0006413)3.89182807
25DNA deamination (GO:0045006)3.81124082
26mitochondrial respiratory chain complex I assembly (GO:0032981)3.80820817
27NADH dehydrogenase complex assembly (GO:0010257)3.80820817
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.80820817
29nonmotile primary cilium assembly (GO:0035058)3.79070518
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.70873563
31GTP biosynthetic process (GO:0006183)3.67584331
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.66268433
33nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.62829458
34mitochondrial respiratory chain complex assembly (GO:0033108)3.61251621
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.60311957
36respiratory chain complex IV assembly (GO:0008535)3.53677661
37translation (GO:0006412)3.53176026
38pattern specification involved in kidney development (GO:0061004)3.51178613
39neuron fate determination (GO:0048664)3.47107623
40protein complex disassembly (GO:0043241)3.46132150
41ribosomal large subunit biogenesis (GO:0042273)3.45999062
42L-fucose catabolic process (GO:0042355)3.43507235
43fucose catabolic process (GO:0019317)3.43507235
44L-fucose metabolic process (GO:0042354)3.43507235
45head development (GO:0060322)3.30463287
46macromolecular complex disassembly (GO:0032984)3.27753359
47base-excision repair, AP site formation (GO:0006285)3.26251155
48platelet dense granule organization (GO:0060155)3.21893809
49nuclear-transcribed mRNA catabolic process (GO:0000956)3.21843149
50cellular component biogenesis (GO:0044085)3.21372309
51cytochrome complex assembly (GO:0017004)3.19801798
52electron transport chain (GO:0022900)3.18248664
53protein targeting to membrane (GO:0006612)3.17723168
54respiratory electron transport chain (GO:0022904)3.13885196
55UTP biosynthetic process (GO:0006228)3.12649367
56water-soluble vitamin biosynthetic process (GO:0042364)3.12172608
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.11872548
58kidney morphogenesis (GO:0060993)3.09714800
59ribonucleoprotein complex biogenesis (GO:0022613)3.09194168
60endoderm formation (GO:0001706)3.09089322
61regulation of mesoderm development (GO:2000380)3.08513479
62mRNA catabolic process (GO:0006402)3.05080841
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.05009221
64tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.05009221
65cell proliferation in forebrain (GO:0021846)3.03624920
66replication fork processing (GO:0031297)3.03112838
67somite development (GO:0061053)3.01514067
68axoneme assembly (GO:0035082)2.98857600
69UTP metabolic process (GO:0046051)2.97423051
70detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.91390484
71substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.90431476
72substrate-independent telencephalic tangential migration (GO:0021826)2.90431476
73intracellular protein transmembrane import (GO:0044743)2.90249866
74purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.89400872
75purine nucleoside triphosphate biosynthetic process (GO:0009145)2.88985988
76pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.88391314
77positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.87738584
78regulation of immunoglobulin secretion (GO:0051023)2.87314373
79nephron tubule morphogenesis (GO:0072078)2.84754323
80nephron epithelium morphogenesis (GO:0072088)2.84754323
81peptidyl-histidine modification (GO:0018202)2.83203806
82regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.81348689
83transcription elongation from RNA polymerase III promoter (GO:0006385)2.81316063
84termination of RNA polymerase III transcription (GO:0006386)2.81316063
85epithelial cilium movement (GO:0003351)2.81282753
86negative regulation of telomere maintenance (GO:0032205)2.76810986
87central nervous system myelination (GO:0022010)2.72839284
88axon ensheathment in central nervous system (GO:0032291)2.72839284
89tongue development (GO:0043586)2.72821148
90RNA catabolic process (GO:0006401)2.72046477
91tRNA processing (GO:0008033)2.68544990
92rRNA processing (GO:0006364)2.67772542
93protein-cofactor linkage (GO:0018065)2.66167771
94ATP biosynthetic process (GO:0006754)2.64711358
95aldehyde catabolic process (GO:0046185)2.63095175
96nucleoside diphosphate phosphorylation (GO:0006165)2.61536650
97rRNA metabolic process (GO:0016072)2.60681627
98CTP metabolic process (GO:0046036)2.60008278
99CTP biosynthetic process (GO:0006241)2.60008278
100ubiquinone biosynthetic process (GO:0006744)2.59372912

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.61913595
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.10529931
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.65654866
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.51264017
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06050318
6ZNF274_21170338_ChIP-Seq_K562_Hela2.97263285
7VDR_22108803_ChIP-Seq_LS180_Human2.85313444
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.83245151
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.60234887
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50097626
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36949232
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28705506
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.11591867
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02257085
15EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.91375877
16ELK1_19687146_ChIP-ChIP_HELA_Human1.84300063
17VDR_23849224_ChIP-Seq_CD4+_Human1.82609741
18IGF1R_20145208_ChIP-Seq_DFB_Human1.81581662
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75913806
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.72661719
21MYC_18940864_ChIP-ChIP_HL60_Human1.71719155
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.71368566
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.63575238
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.62830527
25FOXP3_21729870_ChIP-Seq_TREG_Human1.62703944
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56803238
27P300_19829295_ChIP-Seq_ESCs_Human1.56575165
28MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56290071
29TP53_22573176_ChIP-Seq_HFKS_Human1.56273471
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55499890
31EWS_26573619_Chip-Seq_HEK293_Human1.54533370
32GBX2_23144817_ChIP-Seq_PC3_Human1.52806377
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52766203
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.51600956
35GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.50725099
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45256587
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45130395
38FUS_26573619_Chip-Seq_HEK293_Human1.38186069
39TTF2_22483619_ChIP-Seq_HELA_Human1.38060012
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.35919008
41IRF1_19129219_ChIP-ChIP_H3396_Human1.35770285
42GATA3_21878914_ChIP-Seq_MCF-7_Human1.35250541
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35003325
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31891235
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30347930
46ETV2_25802403_ChIP-Seq_MESCs_Mouse1.29240746
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.28748311
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27250807
49GABP_19822575_ChIP-Seq_HepG2_Human1.27005678
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25546369
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23380783
52RNF2_27304074_Chip-Seq_NSC_Mouse1.22547713
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.20714163
54BCAT_22108803_ChIP-Seq_LS180_Human1.19264078
55CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16467504
56TCF4_22108803_ChIP-Seq_LS180_Human1.12565408
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12372558
58AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10817101
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.09838673
60NCOR_22424771_ChIP-Seq_293T_Human1.09304019
61NANOG_19829295_ChIP-Seq_ESCs_Human1.09108818
62SOX2_19829295_ChIP-Seq_ESCs_Human1.09108818
63SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07002150
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04715892
65CBP_20019798_ChIP-Seq_JUKART_Human1.04700371
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04700371
67JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04050063
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03679522
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03532779
70MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02138987
71NANOG_20526341_ChIP-Seq_ESCs_Human1.00441847
72AR_20517297_ChIP-Seq_VCAP_Human0.99162417
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98535019
74ERA_21632823_ChIP-Seq_H3396_Human0.97235941
75HOXB7_26014856_ChIP-Seq_BT474_Human0.97150191
76FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96810185
77FOXA1_25329375_ChIP-Seq_VCAP_Human0.96810185
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93680084
79ER_23166858_ChIP-Seq_MCF-7_Human0.93521666
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91902709
81ELK1_22589737_ChIP-Seq_MCF10A_Human0.91382705
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91328721
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90614692
84P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90568611
85MYC_19079543_ChIP-ChIP_MESCs_Mouse0.89845444
86FOXH1_21741376_ChIP-Seq_EPCs_Human0.88766992
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88378883
88TDRD3_21172665_ChIP-Seq_MCF-7_Human0.87632718
89GATA1_26923725_Chip-Seq_HPCs_Mouse0.87492694
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87405712
91MYC_19030024_ChIP-ChIP_MESCs_Mouse0.86420628
92KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86048922
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85687473
94TAF2_19829295_ChIP-Seq_ESCs_Human0.85503230
95YY1_21170310_ChIP-Seq_MESCs_Mouse0.85366184
96REST_21632747_ChIP-Seq_MESCs_Mouse0.84902039
97PHF8_20622853_ChIP-Seq_HELA_Human0.84567222
98XRN2_22483619_ChIP-Seq_HELA_Human0.84158233
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83910785
100SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83832102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.74108337
2MP0006292_abnormal_olfactory_placode4.70083071
3MP0008789_abnormal_olfactory_epithelium2.87095473
4MP0002102_abnormal_ear_morphology2.56645958
5MP0008877_abnormal_DNA_methylation2.49082288
6MP0003787_abnormal_imprinting2.47829524
7MP0005394_taste/olfaction_phenotype2.37149610
8MP0005499_abnormal_olfactory_system2.37149610
9MP0001293_anophthalmia2.24497961
10MP0002653_abnormal_ependyma_morphology2.19293106
11MP0003122_maternal_imprinting2.15980064
12MP0003646_muscle_fatigue2.07085627
13MP0005646_abnormal_pituitary_gland2.06149856
14MP0006072_abnormal_retinal_apoptosis2.02488834
15MP0004142_abnormal_muscle_tone1.96689199
16MP0010030_abnormal_orbit_morphology1.91398914
17MP0001984_abnormal_olfaction1.86881558
18MP0008872_abnormal_physiological_respon1.77218790
19MP0006276_abnormal_autonomic_nervous1.76560941
20MP0000778_abnormal_nervous_system1.74258499
21MP0004133_heterotaxia1.70131974
22MP0005551_abnormal_eye_electrophysiolog1.69417710
23MP0002938_white_spotting1.69387067
24MP0003567_abnormal_fetal_cardiomyocyte1.69236755
25MP0001485_abnormal_pinna_reflex1.68487215
26MP0003121_genomic_imprinting1.63240476
27MP0003890_abnormal_embryonic-extraembry1.61842680
28MP0008875_abnormal_xenobiotic_pharmacok1.61232883
29MP0001529_abnormal_vocalization1.60411517
30MP0004742_abnormal_vestibular_system1.59818140
31MP0000049_abnormal_middle_ear1.47765308
32MP0002736_abnormal_nociception_after1.46766641
33MP0003283_abnormal_digestive_organ1.45679726
34MP0005084_abnormal_gallbladder_morpholo1.41554603
35MP0004885_abnormal_endolymph1.39649799
36MP0002234_abnormal_pharynx_morphology1.38388794
37MP0000631_abnormal_neuroendocrine_gland1.35218560
38MP0000372_irregular_coat_pigmentation1.31115336
39MP0005195_abnormal_posterior_eye1.30663077
40MP0008058_abnormal_DNA_repair1.30207542
41MP0000026_abnormal_inner_ear1.29112117
42MP0002876_abnormal_thyroid_physiology1.25056714
43MP0003186_abnormal_redox_activity1.24693876
44MP0004145_abnormal_muscle_electrophysio1.23730280
45MP0001486_abnormal_startle_reflex1.23146850
46MP0002557_abnormal_social/conspecific_i1.22832833
47MP0003880_abnormal_central_pattern1.22656464
48MP0002272_abnormal_nervous_system1.21642877
49MP0008995_early_reproductive_senescence1.19966060
50MP0001968_abnormal_touch/_nociception1.19605322
51MP0002095_abnormal_skin_pigmentation1.19233010
52MP0005377_hearing/vestibular/ear_phenot1.18516198
53MP0003878_abnormal_ear_physiology1.18516198
54MP0001286_abnormal_eye_development1.17939593
55MP0002138_abnormal_hepatobiliary_system1.17708518
56MP0003119_abnormal_digestive_system1.16184419
57MP0003937_abnormal_limbs/digits/tail_de1.08368126
58MP0002752_abnormal_somatic_nervous1.07925697
59MP0003936_abnormal_reproductive_system1.06225207
60MP0003195_calcinosis1.01506892
61MP0005389_reproductive_system_phenotype1.00954325
62MP0002733_abnormal_thermal_nociception0.99700185
63MP0002233_abnormal_nose_morphology0.99530945
64MP0004147_increased_porphyrin_level0.99259166
65MP0002160_abnormal_reproductive_system0.98422664
66MP0002277_abnormal_respiratory_mucosa0.96926717
67MP0002210_abnormal_sex_determination0.96692298
68MP0003123_paternal_imprinting0.96400045
69MP0001963_abnormal_hearing_physiology0.96245192
70MP0002184_abnormal_innervation0.94938245
71MP0003938_abnormal_ear_development0.94387343
72MP0009745_abnormal_behavioral_response0.93078653
73MP0005645_abnormal_hypothalamus_physiol0.93071613
74MP0001440_abnormal_grooming_behavior0.92661350
75MP0000427_abnormal_hair_cycle0.92122618
76MP0003786_premature_aging0.91582940
77MP0002163_abnormal_gland_morphology0.90882314
78MP0005253_abnormal_eye_physiology0.90562456
79MP0001986_abnormal_taste_sensitivity0.90420751
80MP0003136_yellow_coat_color0.90316688
81MP0003011_delayed_dark_adaptation0.89721687
82MP0002282_abnormal_trachea_morphology0.88847552
83MP0005174_abnormal_tail_pigmentation0.88421003
84MP0003718_maternal_effect0.87965856
85MP0002837_dystrophic_cardiac_calcinosis0.86130675
86MP0001919_abnormal_reproductive_system0.85609142
87MP0003315_abnormal_perineum_morphology0.84158359
88MP0005085_abnormal_gallbladder_physiolo0.83563486
89MP0002572_abnormal_emotion/affect_behav0.82993394
90MP0001970_abnormal_pain_threshold0.82921552
91MP0002928_abnormal_bile_duct0.80255350
92MP0000613_abnormal_salivary_gland0.80085400
93MP0003755_abnormal_palate_morphology0.79401954
94MP0001324_abnormal_eye_pigmentation0.79276938
95MP0002254_reproductive_system_inflammat0.78983247
96MP0009053_abnormal_anal_canal0.77894856
97MP0005391_vision/eye_phenotype0.77497455
98MP0008775_abnormal_heart_ventricle0.76891041
99MP0001502_abnormal_circadian_rhythm0.76656510
100MP0001119_abnormal_female_reproductive0.72035016

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.59942729
2Acute necrotizing encephalopathy (HP:0006965)3.99006841
3Molar tooth sign on MRI (HP:0002419)3.83028477
4Abnormality of midbrain morphology (HP:0002418)3.83028477
5Acute encephalopathy (HP:0006846)3.69049253
6Abnormality of cells of the erythroid lineage (HP:0012130)3.62139481
7Pancreatic fibrosis (HP:0100732)3.56192188
8Colon cancer (HP:0003003)3.46442393
9Pancreatic cysts (HP:0001737)3.39838386
10Abnormal mitochondria in muscle tissue (HP:0008316)3.38230694
11Mitochondrial inheritance (HP:0001427)3.33355695
12True hermaphroditism (HP:0010459)3.29393157
13Septo-optic dysplasia (HP:0100842)3.26702472
14Asplenia (HP:0001746)3.26494253
15Aplasia/Hypoplasia of the spleen (HP:0010451)3.24542212
16Increased CSF lactate (HP:0002490)3.12853387
17Progressive macrocephaly (HP:0004481)3.10585665
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.10401187
19Nephronophthisis (HP:0000090)3.01313894
20Lipid accumulation in hepatocytes (HP:0006561)2.99042671
21Increased hepatocellular lipid droplets (HP:0006565)2.97247591
22Abnormal rod and cone electroretinograms (HP:0008323)2.81968183
23Abnormality of the renal medulla (HP:0100957)2.80477915
24Stenosis of the external auditory canal (HP:0000402)2.79263835
25Medial flaring of the eyebrow (HP:0010747)2.76839935
26Abnormal number of erythroid precursors (HP:0012131)2.75204553
27Absent thumb (HP:0009777)2.64882951
28Oligodactyly (hands) (HP:0001180)2.63279763
29Hepatocellular necrosis (HP:0001404)2.62797300
30Macrocytic anemia (HP:0001972)2.61548136
31Pendular nystagmus (HP:0012043)2.60668355
32Cerebral edema (HP:0002181)2.58538682
33Hyperglycinemia (HP:0002154)2.49030719
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.48978148
35Type 2 muscle fiber atrophy (HP:0003554)2.46625646
36Congenital stationary night blindness (HP:0007642)2.44724134
37Optic disc pallor (HP:0000543)2.40821813
38Abnormality of the labia minora (HP:0012880)2.37920714
39Sclerocornea (HP:0000647)2.36635302
40Renal Fanconi syndrome (HP:0001994)2.34598601
41Anencephaly (HP:0002323)2.34571015
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.33826000
43Anophthalmia (HP:0000528)2.32351074
44Abnormality of the renal cortex (HP:0011035)2.31612048
45Ectopic kidney (HP:0000086)2.26622407
46Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.23417553
47Hepatic necrosis (HP:0002605)2.23150605
48Optic nerve hypoplasia (HP:0000609)2.20893027
49Maternal diabetes (HP:0009800)2.17806864
50Type II lissencephaly (HP:0007260)2.17670906
51Rib fusion (HP:0000902)2.15140817
52Gait imbalance (HP:0002141)2.13977973
53Aplasia/Hypoplasia of the tongue (HP:0010295)2.13119852
54Cystic liver disease (HP:0006706)2.12238771
55Pallor (HP:0000980)2.07428135
56Tubular atrophy (HP:0000092)2.07157925
57Abnormality of DNA repair (HP:0003254)2.06560130
58Congenital primary aphakia (HP:0007707)2.06526221
59Oligodactyly (HP:0012165)2.06523831
60Increased serum lactate (HP:0002151)2.05587690
61Supernumerary spleens (HP:0009799)2.05428261
62Postaxial foot polydactyly (HP:0001830)2.04525578
63Hypoplasia of the radius (HP:0002984)2.03732920
64Nephrogenic diabetes insipidus (HP:0009806)2.03378508
65Muscle fiber atrophy (HP:0100295)1.98610912
66Hypoplasia of the ulna (HP:0003022)1.95415820
67Hypomagnesemia (HP:0002917)1.95008072
68Shawl scrotum (HP:0000049)1.93242913
69Abnormal pancreas size (HP:0012094)1.92113040
70Absent septum pellucidum (HP:0001331)1.91224118
71Adrenal hypoplasia (HP:0000835)1.89785592
72Forearm undergrowth (HP:0009821)1.87348440
73Male pseudohermaphroditism (HP:0000037)1.86759323
74Optic nerve coloboma (HP:0000588)1.85830249
75Exertional dyspnea (HP:0002875)1.85410911
76Respiratory difficulties (HP:0002880)1.85136841
77Polyuria (HP:0000103)1.84176487
78Lactic acidosis (HP:0003128)1.83902305
79Horseshoe kidney (HP:0000085)1.83599400
80Narrow forehead (HP:0000341)1.82023160
81Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81356675
82Congenital hepatic fibrosis (HP:0002612)1.80751182
83Attenuation of retinal blood vessels (HP:0007843)1.79331132
84Abolished electroretinogram (ERG) (HP:0000550)1.78819147
85Bile duct proliferation (HP:0001408)1.78629176
86Abnormal biliary tract physiology (HP:0012439)1.78629176
87Stomatitis (HP:0010280)1.78507465
88Preaxial hand polydactyly (HP:0001177)1.78428512
89Lethargy (HP:0001254)1.77627625
90Depressed nasal ridge (HP:0000457)1.77522591
91Occipital encephalocele (HP:0002085)1.76313177
92Holoprosencephaly (HP:0001360)1.76243407
93Abnormality of urine glucose concentration (HP:0011016)1.76072486
94Glycosuria (HP:0003076)1.76072486
95Abnormality of magnesium homeostasis (HP:0004921)1.75748157
96Porencephaly (HP:0002132)1.75211754
97Hyperglycinuria (HP:0003108)1.74287670
98Abnormal drinking behavior (HP:0030082)1.73829250
99Polydipsia (HP:0001959)1.73829250
100Lissencephaly (HP:0001339)1.71889986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK43.41425029
2BMPR1B2.76340225
3MST42.66167802
4MAP4K22.54034377
5STK162.52155710
6ZAK2.51178690
7NUAK12.42011791
8ADRBK22.26205217
9VRK22.25664502
10DYRK22.21040572
11GRK12.07947504
12PLK21.93272059
13EPHB21.89254639
14BCKDK1.89061736
15TNIK1.83528134
16STK391.82190778
17PIK3CA1.72909916
18NEK11.68183385
19PAK31.47298853
20WNK31.45905420
21TAF11.45608439
22MKNK21.41925594
23PINK11.38614920
24LRRK21.35743043
25CASK1.33664325
26TGFBR11.30945183
27PDK21.28908921
28VRK11.19160075
29NME11.18695589
30OXSR11.17641273
31TXK1.14646610
32CDC71.12375538
33MAPK131.11264421
34TLK11.07531532
35NTRK21.07431994
36PRKCI1.05380391
37ADRBK11.04826437
38GRK71.00644272
39PASK1.00052139
40INSRR0.96901633
41PLK30.96822605
42MAP3K40.96030098
43CDK190.95200994
44FRK0.93742796
45PRKCG0.93294675
46MAP3K110.90810145
47TIE10.89487820
48TAOK30.89169224
49CSNK1G20.88781292
50EPHA40.87713717
51PLK40.87670649
52MUSK0.86944443
53EIF2AK10.84776648
54STK110.81762901
55ACVR1B0.80321974
56PRKCQ0.76316166
57TYRO30.74603205
58RPS6KA60.72531528
59EIF2AK20.71986085
60DAPK20.71127650
61CAMK10.68130245
62CSNK1G30.68092086
63SRPK10.67579463
64TEC0.67363269
65TRIM280.64026584
66AURKB0.63895854
67GRK50.62576027
68DAPK30.62276014
69CSNK1E0.59737416
70FLT30.59593959
71PAK60.58847824
72PLK10.58646107
73CSNK1G10.58273314
74RPS6KL10.57606820
75RPS6KC10.57606820
76CSNK1A1L0.57166873
77AURKA0.57091936
78PRKCH0.57001299
79BCR0.56444636
80PRKCE0.55003313
81ATR0.53655361
82WNK10.53558089
83CSNK2A20.51963116
84PBK0.48857545
85PRKACA0.48733512
86MAP2K60.48204062
87MINK10.47140234
88RPS6KA20.46028811
89CHEK20.45865398
90MKNK10.42831672
91PHKG10.41255572
92PHKG20.41255572
93BRAF0.36203152
94EIF2AK30.36004786
95CSNK2A10.34249363
96PRKCZ0.33130226
97PRKCA0.32370060
98ATM0.32054671
99ITK0.31165517
100MOS0.30851482

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.11888651
2Oxidative phosphorylation_Homo sapiens_hsa001903.32529239
3Parkinsons disease_Homo sapiens_hsa050122.97030839
4Proteasome_Homo sapiens_hsa030502.83013680
5Protein export_Homo sapiens_hsa030602.43614218
6RNA polymerase_Homo sapiens_hsa030202.42795227
7Basal transcription factors_Homo sapiens_hsa030222.42425093
8Huntingtons disease_Homo sapiens_hsa050162.15217006
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.13764923
10RNA degradation_Homo sapiens_hsa030182.10580432
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94743360
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92421718
13Linoleic acid metabolism_Homo sapiens_hsa005911.92346548
14Alzheimers disease_Homo sapiens_hsa050101.83380128
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.82269855
16Cardiac muscle contraction_Homo sapiens_hsa042601.81252184
17Steroid biosynthesis_Homo sapiens_hsa001001.78753331
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75151498
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.68077306
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.66830456
21Homologous recombination_Homo sapiens_hsa034401.60328065
22Asthma_Homo sapiens_hsa053101.57969403
23One carbon pool by folate_Homo sapiens_hsa006701.54370103
24Propanoate metabolism_Homo sapiens_hsa006401.54171696
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42843342
26Phototransduction_Homo sapiens_hsa047441.42768444
27Peroxisome_Homo sapiens_hsa041461.39541156
28Nucleotide excision repair_Homo sapiens_hsa034201.38576863
29Sulfur relay system_Homo sapiens_hsa041221.35864416
30Fanconi anemia pathway_Homo sapiens_hsa034601.26477225
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24733992
32Mismatch repair_Homo sapiens_hsa034301.21683778
33Butanoate metabolism_Homo sapiens_hsa006501.21345008
34Fat digestion and absorption_Homo sapiens_hsa049751.19568329
35Caffeine metabolism_Homo sapiens_hsa002321.17548241
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13709761
37Tryptophan metabolism_Homo sapiens_hsa003801.12805981
38Fatty acid degradation_Homo sapiens_hsa000711.12665968
39Pyrimidine metabolism_Homo sapiens_hsa002401.12215142
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12126357
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08645809
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.04145269
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02472011
44RNA transport_Homo sapiens_hsa030131.01983493
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98977175
46Basal cell carcinoma_Homo sapiens_hsa052170.95651926
47Ether lipid metabolism_Homo sapiens_hsa005650.95493377
48Nitrogen metabolism_Homo sapiens_hsa009100.94594769
49Base excision repair_Homo sapiens_hsa034100.94168696
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93463782
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93303480
52Allograft rejection_Homo sapiens_hsa053300.89565148
53Chemical carcinogenesis_Homo sapiens_hsa052040.89346904
54Vitamin B6 metabolism_Homo sapiens_hsa007500.87723457
55Sulfur metabolism_Homo sapiens_hsa009200.87685431
56Hedgehog signaling pathway_Homo sapiens_hsa043400.86584238
57Autoimmune thyroid disease_Homo sapiens_hsa053200.82037507
58Arachidonic acid metabolism_Homo sapiens_hsa005900.81948449
59beta-Alanine metabolism_Homo sapiens_hsa004100.81710977
60Retinol metabolism_Homo sapiens_hsa008300.79463024
61Nicotine addiction_Homo sapiens_hsa050330.78192567
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.78012729
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77165120
64Purine metabolism_Homo sapiens_hsa002300.77118060
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.74974857
66Fatty acid metabolism_Homo sapiens_hsa012120.74475090
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.73613375
68Olfactory transduction_Homo sapiens_hsa047400.72489073
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72448706
70Metabolic pathways_Homo sapiens_hsa011000.71890361
71Pyruvate metabolism_Homo sapiens_hsa006200.70063546
72Selenocompound metabolism_Homo sapiens_hsa004500.68926483
73Non-homologous end-joining_Homo sapiens_hsa034500.63869888
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61742876
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61058979
76DNA replication_Homo sapiens_hsa030300.58525952
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57379143
78Folate biosynthesis_Homo sapiens_hsa007900.53217388
79Spliceosome_Homo sapiens_hsa030400.51498610
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49701681
81Regulation of autophagy_Homo sapiens_hsa041400.49633468
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49622133
83Hippo signaling pathway_Homo sapiens_hsa043900.46030950
84Arginine and proline metabolism_Homo sapiens_hsa003300.44160909
85Fatty acid elongation_Homo sapiens_hsa000620.43267240
86Primary immunodeficiency_Homo sapiens_hsa053400.42763854
87Type I diabetes mellitus_Homo sapiens_hsa049400.40273320
88Glutathione metabolism_Homo sapiens_hsa004800.36764783
89Graft-versus-host disease_Homo sapiens_hsa053320.36294728
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35489759
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33068402
92Morphine addiction_Homo sapiens_hsa050320.32318958
93Glycerolipid metabolism_Homo sapiens_hsa005610.30972654
94Ovarian steroidogenesis_Homo sapiens_hsa049130.28508225
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28313063
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.27973464
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27017303
98Tyrosine metabolism_Homo sapiens_hsa003500.25547465
99Wnt signaling pathway_Homo sapiens_hsa043100.25528553
100Taste transduction_Homo sapiens_hsa047420.23979201

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