RPS23P10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K6-linked ubiquitination (GO:0085020)5.38373884
2somatic diversification of immunoglobulins involved in immune response (GO:0002208)4.86590370
3isotype switching (GO:0045190)4.86590370
4somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)4.86590370
5DNA deamination (GO:0045006)4.81355667
6negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.68913245
7cellular extravasation (GO:0045123)4.46026539
8positive regulation of interleukin-12 production (GO:0032735)4.26849080
9regulation of immunoglobulin secretion (GO:0051023)4.13287732
10negative regulation of alpha-beta T cell differentiation (GO:0046639)3.90476489
11positive regulation of T cell migration (GO:2000406)3.80705727
12response to peptidoglycan (GO:0032494)3.80379606
13negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.69694755
14defense response to protozoan (GO:0042832)3.69167922
15somatic recombination of immunoglobulin gene segments (GO:0016447)3.63524943
16neutrophil activation involved in immune response (GO:0002283)3.63512104
17autophagic vacuole fusion (GO:0000046)3.57313371
18artery development (GO:0060840)3.56618106
19proline transport (GO:0015824)3.48565480
20neutrophil mediated immunity (GO:0002446)3.47505573
21regulation of interleukin-12 production (GO:0032655)3.47038267
22negative regulation of smooth muscle cell differentiation (GO:0051151)3.46174733
23regulation of T cell migration (GO:2000404)3.41876855
24somatic diversification of immunoglobulins (GO:0016445)3.32618897
25negative thymic T cell selection (GO:0045060)3.30087446
26positive regulation of endothelial cell apoptotic process (GO:2000353)3.23625298
27regulation of translation in response to stress (GO:0043555)3.22602262
28N-acetylglucosamine metabolic process (GO:0006044)3.22204897
29positive regulation of lymphocyte migration (GO:2000403)3.20334652
30leukocyte migration involved in inflammatory response (GO:0002523)3.19883607
31regulation of chromatin silencing (GO:0031935)3.15302016
32response to protozoan (GO:0001562)3.12890430
33positive regulation of granulocyte differentiation (GO:0030854)3.10163386
34negative T cell selection (GO:0043383)3.09270319
35negative regulation of alpha-beta T cell activation (GO:0046636)3.09154330
36organelle membrane fusion (GO:0090174)3.05802178
37regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.04756308
38positive regulation of viral genome replication (GO:0045070)3.02664333
39cilium or flagellum-dependent cell motility (GO:0001539)3.02011041
40somite development (GO:0061053)3.00125462
41opioid receptor signaling pathway (GO:0038003)2.99166745
42N-acetylneuraminate metabolic process (GO:0006054)2.97703138
43positive regulation of gamma-delta T cell activation (GO:0046645)2.92938529
44regulation of interleukin-6 biosynthetic process (GO:0045408)2.92844377
45regulation of neutrophil chemotaxis (GO:0090022)2.92806130
46regulation of neutrophil migration (GO:1902622)2.92806130
47detection of molecule of bacterial origin (GO:0032490)2.92568481
48regulation of Rac protein signal transduction (GO:0035020)2.91870169
49negative regulation of growth of symbiont in host (GO:0044130)2.91536298
50negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.91536298
51modulation of growth of symbiont involved in interaction with host (GO:0044144)2.91536298
52regulation of growth of symbiont in host (GO:0044126)2.91536298
53B cell activation involved in immune response (GO:0002312)2.87146442
54negative regulation of mast cell activation (GO:0033004)2.85835493
55negative regulation of DNA-templated transcription, elongation (GO:0032785)2.85164431
56regulation of tolerance induction (GO:0002643)2.85047349
57negative regulation of cAMP-mediated signaling (GO:0043951)2.84779832
58regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84410210
59regulation of mitotic spindle checkpoint (GO:1903504)2.84410210
60positive regulation of toll-like receptor signaling pathway (GO:0034123)2.82422999
61regulation of skeletal muscle contraction (GO:0014819)2.82302753
62positive regulation of respiratory burst (GO:0060267)2.77686845
63negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.77260569
64negative regulation of cell killing (GO:0031342)2.77260569
65negative regulation of protein oligomerization (GO:0032460)2.76533064
66regulation of memory T cell differentiation (GO:0043380)2.75982513
67neutrophil activation (GO:0042119)2.72764443
68positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)2.71692850
69positive regulation of tolerance induction (GO:0002645)2.70224689
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.69917916
71negative regulation of exocytosis (GO:0045920)2.64877549
72alanine transport (GO:0032328)2.64306060
73pantothenate metabolic process (GO:0015939)2.63673006
74necroptotic process (GO:0070266)2.63598801
75negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.62802892
76negative regulation of interleukin-12 production (GO:0032695)2.62550504
77B cell proliferation (GO:0042100)2.61484729
78positive regulation of cell cycle G1/S phase transition (GO:1902808)2.60072823
79nitric oxide mediated signal transduction (GO:0007263)2.56979424
80negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.55586395
81positive regulation of DNA recombination (GO:0045911)2.54945703
82glycine transport (GO:0015816)2.54697965
83signal peptide processing (GO:0006465)2.53219085
84regulation of MHC class II biosynthetic process (GO:0045346)2.52130273
85regulation of granulocyte differentiation (GO:0030852)2.51830163
86myeloid leukocyte mediated immunity (GO:0002444)2.51419246
87regulation of toll-like receptor signaling pathway (GO:0034121)2.51412186
88superoxide anion generation (GO:0042554)2.49485747
89cardiolipin metabolic process (GO:0032048)2.49155576
90regulation of mast cell activation (GO:0033003)2.47154863
91cellular response to dsRNA (GO:0071359)2.46251161
92negative regulation of T-helper cell differentiation (GO:0045623)2.45360012
93negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.45360012
94regulation of lymphocyte migration (GO:2000401)2.45083265
95negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.40756054
96negative regulation of translation, ncRNA-mediated (GO:0040033)2.40756054
97regulation of translation, ncRNA-mediated (GO:0045974)2.40756054
98positive T cell selection (GO:0043368)2.40478602
99detection of external biotic stimulus (GO:0098581)2.40436029
100negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.40261970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.90512207
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.01246131
3LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.67867565
4ZNF274_21170338_ChIP-Seq_K562_Hela2.55506299
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.51843819
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.38544579
7GBX2_23144817_ChIP-Seq_PC3_Human2.27587468
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.13866391
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.11382624
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.07908548
11BCAT_22108803_ChIP-Seq_LS180_Human2.06772147
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.02236158
13VDR_24787735_ChIP-Seq_THP-1_Human1.96619803
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90264622
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.89813720
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.79002808
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.78530043
18SCL_19346495_ChIP-Seq_HPC-7_Human1.77855681
19SPI1_23547873_ChIP-Seq_NB4_Human1.77286995
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74819228
21EGR1_19032775_ChIP-ChIP_M12_Human1.72344496
22SMRT_27268052_Chip-Seq_Bcells_Human1.71952950
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.71907614
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.68357550
25ER_23166858_ChIP-Seq_MCF-7_Human1.67707308
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.63791896
27TP53_22573176_ChIP-Seq_HFKS_Human1.63485084
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62621891
29LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62168928
30RUNX_20019798_ChIP-Seq_JUKART_Human1.61196396
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56198873
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51164098
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49176322
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48338841
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47496643
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.42171233
37GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.40748296
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40220701
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.40147358
40VDR_22108803_ChIP-Seq_LS180_Human1.38393530
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36055348
42VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.32582832
43EWS_26573619_Chip-Seq_HEK293_Human1.31362577
44P300_19829295_ChIP-Seq_ESCs_Human1.31043851
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30822947
46SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29766680
47IRF1_19129219_ChIP-ChIP_H3396_Human1.29439466
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29037612
49NANOG_20526341_ChIP-Seq_ESCs_Human1.27128374
50SPI1_23127762_ChIP-Seq_K562_Human1.27069622
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25922522
52VDR_24763502_ChIP-Seq_THP-1_Human1.24773224
53MYB_26560356_Chip-Seq_TH2_Human1.24200653
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23821301
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23290581
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.23224175
57GATA3_26560356_Chip-Seq_TH2_Human1.23220256
58TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22945578
59GATA3_26560356_Chip-Seq_TH1_Human1.20406899
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19299607
61GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.18263758
62GATA1_22025678_ChIP-Seq_K562_Human1.17872335
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17834658
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15897636
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14277053
66PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12738190
67TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.12697405
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11430046
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11264084
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.10640922
71GATA3_27048872_Chip-Seq_THYMUS_Human1.10169200
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09516578
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07503155
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.07388932
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05243365
76TAF15_26573619_Chip-Seq_HEK293_Human1.05184479
77AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04576518
78NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04508226
79RUNX2_22187159_ChIP-Seq_PCA_Human1.03154074
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.02630106
81IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02613711
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01232694
83TCF4_23295773_ChIP-Seq_U87_Human1.01221349
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00501453
85SALL4_22934838_ChIP-ChIP_CD34+_Human1.00434448
86TBL1_22424771_ChIP-Seq_293T_Human0.99904215
87HOXB7_26014856_ChIP-Seq_BT474_Human0.99603055
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99075824
89ETV1_20927104_ChIP-Seq_GIST48_Human0.98658899
90RXR_22108803_ChIP-Seq_LS180_Human0.97769280
91NFYA_21822215_ChIP-Seq_K562_Human0.97753040
92TAF2_19829295_ChIP-Seq_ESCs_Human0.97130691
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96978267
94CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96783450
95P300_27268052_Chip-Seq_Bcells_Human0.96411745
96HTT_18923047_ChIP-ChIP_STHdh_Human0.95887491
97TCF4_18268006_ChIP-ChIP_LS174T_Human0.94441077
98PHF8_20622853_ChIP-Seq_HELA_Human0.93773150
99NFYB_21822215_ChIP-Seq_K562_Human0.93594238
100UTX_26944678_Chip-Seq_JUKART_Human0.92688318

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ6.88915529
2MP0002102_abnormal_ear_morphology5.21019365
3MP0000685_abnormal_immune_system4.02483944
4MP0001835_abnormal_antigen_presentation3.51574289
5MP0003195_calcinosis3.39202077
6MP0002822_catalepsy3.34293281
7MP0001501_abnormal_sleep_pattern2.83726862
8MP0003724_increased_susceptibility_to2.68004312
9MP0009053_abnormal_anal_canal2.56805273
10MP0006082_CNS_inflammation2.28267805
11MP0002138_abnormal_hepatobiliary_system2.14858042
12MP0003252_abnormal_bile_duct2.13868015
13MP0003436_decreased_susceptibility_to2.02891185
14MP0005387_immune_system_phenotype2.01422713
15MP0001790_abnormal_immune_system2.01422713
16MP0005645_abnormal_hypothalamus_physiol2.00108548
17MP0008877_abnormal_DNA_methylation1.96244220
18MP0005083_abnormal_biliary_tract1.86708425
19MP0005671_abnormal_response_to1.71718756
20MP0005167_abnormal_blood-brain_barrier1.67513245
21MP0001800_abnormal_humoral_immune1.62802297
22MP0000383_abnormal_hair_follicle1.61072162
23MP0005025_abnormal_response_to1.57563305
24MP0009785_altered_susceptibility_to1.56494202
25MP0005646_abnormal_pituitary_gland1.53561273
26MP0002723_abnormal_immune_serum1.49988842
27MP0000569_abnormal_digit_pigmentation1.49004494
28MP0008058_abnormal_DNA_repair1.47936506
29MP0003329_amyloid_beta_deposits1.43762717
30MP0001188_hyperpigmentation1.42060088
31MP0005084_abnormal_gallbladder_morpholo1.40935775
32MP0002396_abnormal_hematopoietic_system1.40049538
33MP0003943_abnormal_hepatobiliary_system1.38953112
34MP0003045_fibrosis1.38160807
35MP0008057_abnormal_DNA_replication1.37682604
36MP0002419_abnormal_innate_immunity1.34327241
37MP0001819_abnormal_immune_cell1.32191605
38MP0002420_abnormal_adaptive_immunity1.31990312
39MP0002735_abnormal_chemical_nociception1.31829494
40MP0003718_maternal_effect1.31570125
41MP0002876_abnormal_thyroid_physiology1.31499886
42MP0002168_other_aberrant_phenotype1.30087103
43MP0003567_abnormal_fetal_cardiomyocyte1.29373614
44MP0002452_abnormal_antigen_presenting1.26429555
45MP0001533_abnormal_skeleton_physiology1.26348983
46MP0005464_abnormal_platelet_physiology1.24006542
47MP0005000_abnormal_immune_tolerance1.23564408
48MP0006292_abnormal_olfactory_placode1.21414147
49MP0000604_amyloidosis1.20479527
50MP0005395_other_phenotype1.16605061
51MP0000427_abnormal_hair_cycle1.13095168
52MP0002148_abnormal_hypersensitivity_rea1.13031748
53MP0009764_decreased_sensitivity_to1.12652111
54MP0003075_altered_response_to1.10884874
55MP0003011_delayed_dark_adaptation1.08202924
56MP0009765_abnormal_xenobiotic_induced1.07626447
57MP0010155_abnormal_intestine_physiology1.07531678
58MP0005360_urolithiasis1.07480611
59MP0000631_abnormal_neuroendocrine_gland1.06154939
60MP0003787_abnormal_imprinting1.04592769
61MP0000689_abnormal_spleen_morphology1.03271720
62MP0000716_abnormal_immune_system1.00833669
63MP0000462_abnormal_digestive_system0.99920149
64MP0001764_abnormal_homeostasis0.98264697
65MP0008004_abnormal_stomach_pH0.94914754
66MP0005085_abnormal_gallbladder_physiolo0.94845189
67MP0002398_abnormal_bone_marrow0.92174315
68MP0005253_abnormal_eye_physiology0.91683556
69MP0005410_abnormal_fertilization0.86218165
70MP0008569_lethality_at_weaning0.83209847
71MP0002254_reproductive_system_inflammat0.82667132
72MP0001845_abnormal_inflammatory_respons0.81806502
73MP0009278_abnormal_bone_marrow0.78524509
74MP0002429_abnormal_blood_cell0.78395520
75MP0009763_increased_sensitivity_to0.77930108
76MP0002733_abnormal_thermal_nociception0.75619974
77MP0002722_abnormal_immune_system0.75264578
78MP0001485_abnormal_pinna_reflex0.74825679
79MP0003866_abnormal_defecation0.74454985
80MP0005670_abnormal_white_adipose0.74096750
81MP0003115_abnormal_respiratory_system0.71623582
82MP0001293_anophthalmia0.67737197
83MP0003638_abnormal_response/metabolism_0.66808171
84MP0000703_abnormal_thymus_morphology0.66238523
85MP0001919_abnormal_reproductive_system0.66012804
86MP0004742_abnormal_vestibular_system0.65706050
87MP0004885_abnormal_endolymph0.65215030
88MP0003633_abnormal_nervous_system0.65161078
89MP0004381_abnormal_hair_follicle0.63987022
90MP0008469_abnormal_protein_level0.62320756
91MP0001486_abnormal_startle_reflex0.61555790
92MP0000490_abnormal_crypts_of0.61289429
93MP0001968_abnormal_touch/_nociception0.60521561
94MP0000566_synostosis0.57495232
95MP0001545_abnormal_hematopoietic_system0.56120134
96MP0005397_hematopoietic_system_phenotyp0.56120134
97MP0002693_abnormal_pancreas_physiology0.54806010
98MP0004858_abnormal_nervous_system0.52882711
99MP0008872_abnormal_physiological_respon0.52367170
100MP0005647_abnormal_sex_gland0.51289425

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)9.22566560
2Abnormality of the lower motor neuron (HP:0002366)8.74230206
3Amyotrophic lateral sclerosis (HP:0007354)6.36789044
4Increased IgM level (HP:0003496)5.74624432
5Tetraparesis (HP:0002273)4.48916539
6Delusions (HP:0000746)3.81823280
7Abnormality of T cell physiology (HP:0011840)3.72916184
8Recurrent gram-negative bacterial infections (HP:0005420)3.33376557
9Stomach cancer (HP:0012126)3.26543538
10Abnormality of incisor morphology (HP:0011063)3.20410908
11IgA deficiency (HP:0002720)3.19637553
12IgG deficiency (HP:0004315)3.16702976
13Myositis (HP:0100614)3.04405908
14Congenital stationary night blindness (HP:0007642)2.90412305
15Episodic fever (HP:0001954)2.85738631
16Abnormal delayed hypersensitivity skin test (HP:0002963)2.78841337
17Gingivitis (HP:0000230)2.74863888
18Impulsivity (HP:0100710)2.74405295
19Recurrent cutaneous fungal infections (HP:0011370)2.70144347
20Chronic mucocutaneous candidiasis (HP:0002728)2.70144347
21Recurrent bacterial skin infections (HP:0005406)2.66579352
22Supranuclear gaze palsy (HP:0000605)2.64941631
23Dyskinesia (HP:0100660)2.60258565
24Cerebellar dysplasia (HP:0007033)2.59233186
25Orchitis (HP:0100796)2.57877416
26Atrophy/Degeneration involving motor neurons (HP:0007373)2.55201744
27Abnormality of T cells (HP:0002843)2.51747329
28Cerebral hypomyelination (HP:0006808)2.49378042
29Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.48172739
30Short 4th metacarpal (HP:0010044)2.48172739
31Recurrent skin infections (HP:0001581)2.46218819
32Gonadotropin excess (HP:0000837)2.44514527
33Pendular nystagmus (HP:0012043)2.43772728
34Growth hormone deficiency (HP:0000824)2.43541082
35Pustule (HP:0200039)2.30515157
36Methylmalonic acidemia (HP:0002912)2.29124256
37Recurrent fungal infections (HP:0002841)2.26882781
38Hypochromic microcytic anemia (HP:0004840)2.26302542
39Recurrent abscess formation (HP:0002722)2.25422833
40Decreased central vision (HP:0007663)2.24123484
41Cone-rod dystrophy (HP:0000548)2.21803394
42Truncal obesity (HP:0001956)2.20731034
43Nephronophthisis (HP:0000090)2.17180929
44Upper motor neuron abnormality (HP:0002127)2.15041766
45Apathy (HP:0000741)2.14839853
46Prolonged bleeding time (HP:0003010)2.14283558
47Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.12348904
48Methylmalonic aciduria (HP:0012120)2.11792760
49Prostate neoplasm (HP:0100787)2.09522969
50Optic neuritis (HP:0100653)2.09411922
51Retrobulbar optic neuritis (HP:0100654)2.09411922
52Amyloidosis (HP:0011034)2.09222892
53Elevated erythrocyte sedimentation rate (HP:0003565)2.08298978
54Keratoconjunctivitis (HP:0001096)2.06120306
55Malnutrition (HP:0004395)2.05913644
56Eczematoid dermatitis (HP:0000976)2.04201392
57Spontaneous hematomas (HP:0007420)2.03279622
58Bilateral microphthalmos (HP:0007633)2.02027400
59Mediastinal lymphadenopathy (HP:0100721)2.01447281
60Hypergammaglobulinemia (HP:0010702)2.01443473
61Narrow palate (HP:0000189)1.97945559
62Long toe (HP:0010511)1.97214942
63Abnormality of vision evoked potentials (HP:0000649)1.96746263
64Abnormality of the prostate (HP:0008775)1.92625564
65Abnormality of the renal medulla (HP:0100957)1.92300500
66Progressive sensorineural hearing impairment (HP:0000408)1.90971413
67Chronic hepatic failure (HP:0100626)1.90138773
68Abnormality of midbrain morphology (HP:0002418)1.87251237
69Molar tooth sign on MRI (HP:0002419)1.87251237
70Diminished motivation (HP:0000745)1.87033770
71Neutropenia (HP:0001875)1.86028580
72Poikilocytosis (HP:0004447)1.82475062
73Hypoglycemic seizures (HP:0002173)1.82446306
74Lymphopenia (HP:0001888)1.80492681
75Abnormal drinking behavior (HP:0030082)1.80345843
76Polydipsia (HP:0001959)1.80345843
77Alveolar cell carcinoma (HP:0006519)1.78827814
78Aplasia/Hypoplasia of the tongue (HP:0010295)1.77449549
79True hermaphroditism (HP:0010459)1.77372123
80Hypoplasia of the uterus (HP:0000013)1.77087804
81Constricted visual fields (HP:0001133)1.75722199
82Petechiae (HP:0000967)1.75591706
83Gingival bleeding (HP:0000225)1.73720156
84Enlarged kidneys (HP:0000105)1.73040511
85Pancreatic cysts (HP:0001737)1.71429800
86Type II lissencephaly (HP:0007260)1.70512407
87Lipid accumulation in hepatocytes (HP:0006561)1.70282166
88Chronic sinusitis (HP:0011109)1.69919119
89Severe visual impairment (HP:0001141)1.69010552
90Decreased circulating renin level (HP:0003351)1.68064875
91Agitation (HP:0000713)1.67453030
92Colon cancer (HP:0003003)1.66938614
93Hand muscle atrophy (HP:0009130)1.66790235
94Abnormality of vitamin B metabolism (HP:0004340)1.66763471
95Abnormal neuron morphology (HP:0012757)1.66667684
96Abnormality of the motor neurons (HP:0002450)1.66667684
97Basal cell carcinoma (HP:0002671)1.62255056
98Keratoconjunctivitis sicca (HP:0001097)1.62214678
99Epistaxis (HP:0000421)1.62115022
100Porencephaly (HP:0002132)1.61847050

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD34.89387857
2ZAK3.88526199
3PBK2.40752508
4NUAK12.33490638
5PRKD22.31211151
6TYK22.28101924
7WNK32.19196555
8PASK1.99572404
9ADRBK21.87069396
10MAPK131.85386491
11PTK2B1.84117872
12DYRK31.83001666
13AKT31.74966100
14ACVR1B1.71638224
15RIPK41.69955459
16MAP3K61.69547684
17TNK21.68816008
18ERN11.65775052
19NTRK31.64153722
20BTK1.63843542
21GRK61.63466914
22BLK1.54271265
23MAP3K21.53264836
24FRK1.48015671
25LIMK11.45186531
26RPS6KA41.35445761
27MKNK11.33509335
28PKN11.31493011
29MAPKAPK31.27786169
30TXK1.27322192
31PRKCH1.24788764
32IRAK41.24186090
33IKBKE1.22395396
34MAP3K51.14731194
35BMPR1B1.13640514
36GRK51.06968999
37HCK1.02149913
38MELK1.02116206
39TESK11.01279988
40MAPKAPK50.95105232
41IKBKB0.91344826
42GRK10.91062796
43TEC0.90742470
44ERBB30.87740533
45ZAP700.85496672
46KIT0.84617614
47CLK10.84608099
48DAPK20.84594763
49MAP3K40.84319491
50ABL20.83976741
51SYK0.82623801
52MAPK110.82237404
53SIK30.81307897
54PAK30.80181611
55RPS6KA60.79893303
56TRPM70.79477687
57ADRBK10.78622407
58PRKG20.77128167
59RET0.75435248
60GRK70.73544389
61MAP2K20.71250046
62DMPK0.70944574
63PRKCQ0.69775795
64JAK20.68494542
65BRD40.67523563
66PDK10.66324354
67HIPK20.65114996
68CAMK10.64743885
69OXSR10.64562500
70RPS6KC10.64021387
71RPS6KL10.64021387
72MAP2K30.63684497
73LYN0.60738479
74RAF10.60497451
75SRPK10.59330686
76TRIM280.57213432
77JAK10.56783181
78SGK20.55430815
79MAP4K10.55420658
80MAP2K60.53913657
81LCK0.53262681
82PRKCE0.52964653
83RPS6KB20.52145013
84MAP2K40.48959542
85PLK20.48705656
86CSF1R0.48383461
87IRAK10.48132646
88TAOK30.46033941
89MKNK20.44255403
90CSK0.42823967
91BCKDK0.40867514
92STK390.39333707
93PDPK10.39270145
94PDK20.39171289
95DYRK20.38974987
96ICK0.37630633
97TGFBR20.37091084
98TAOK10.36766587
99RPS6KA50.36618876
100FES0.35964179

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.00068954
2Primary immunodeficiency_Homo sapiens_hsa053403.56232038
3Asthma_Homo sapiens_hsa053103.46550281
4Vitamin B6 metabolism_Homo sapiens_hsa007503.31583410
5Autoimmune thyroid disease_Homo sapiens_hsa053203.07291628
6Allograft rejection_Homo sapiens_hsa053303.02123369
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.61440731
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.41593290
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.23288012
10Linoleic acid metabolism_Homo sapiens_hsa005912.15313948
11Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.97853117
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.94631745
13Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.92817089
14Cyanoamino acid metabolism_Homo sapiens_hsa004601.70759055
15Arachidonic acid metabolism_Homo sapiens_hsa005901.70208201
16Collecting duct acid secretion_Homo sapiens_hsa049661.66541994
17Ovarian steroidogenesis_Homo sapiens_hsa049131.63296111
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52109037
19T cell receptor signaling pathway_Homo sapiens_hsa046601.44815449
20Rheumatoid arthritis_Homo sapiens_hsa053231.41162047
21Serotonergic synapse_Homo sapiens_hsa047261.40846748
22Chemokine signaling pathway_Homo sapiens_hsa040621.38686585
23Type I diabetes mellitus_Homo sapiens_hsa049401.36494122
24Viral myocarditis_Homo sapiens_hsa054161.32891988
25Osteoclast differentiation_Homo sapiens_hsa043801.32831992
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29460604
27Malaria_Homo sapiens_hsa051441.27756858
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22091055
29Staphylococcus aureus infection_Homo sapiens_hsa051501.17825274
30Graft-versus-host disease_Homo sapiens_hsa053321.17247700
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.14350294
32Platelet activation_Homo sapiens_hsa046111.13764686
33Caffeine metabolism_Homo sapiens_hsa002321.13114614
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12783156
35Ether lipid metabolism_Homo sapiens_hsa005651.09918959
36Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.06738216
37Leishmaniasis_Homo sapiens_hsa051401.05265766
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04834682
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02576203
40Tuberculosis_Homo sapiens_hsa051521.00996274
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99838050
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96718091
43Hematopoietic cell lineage_Homo sapiens_hsa046400.95941525
44Prolactin signaling pathway_Homo sapiens_hsa049170.95317862
45Non-homologous end-joining_Homo sapiens_hsa034500.93796203
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90553949
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89545547
48Retinol metabolism_Homo sapiens_hsa008300.86511642
49Pertussis_Homo sapiens_hsa051330.84875952
50B cell receptor signaling pathway_Homo sapiens_hsa046620.84532101
51RNA polymerase_Homo sapiens_hsa030200.84224210
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83738904
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.83628233
54Glutathione metabolism_Homo sapiens_hsa004800.83277513
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80616697
56Circadian entrainment_Homo sapiens_hsa047130.78110119
57Chemical carcinogenesis_Homo sapiens_hsa052040.77092596
58Toxoplasmosis_Homo sapiens_hsa051450.74913052
59Renin secretion_Homo sapiens_hsa049240.73663243
60TGF-beta signaling pathway_Homo sapiens_hsa043500.71860069
61Dorso-ventral axis formation_Homo sapiens_hsa043200.69289218
62Butanoate metabolism_Homo sapiens_hsa006500.66485394
63Long-term depression_Homo sapiens_hsa047300.64245776
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61437071
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60565464
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59023052
67Tryptophan metabolism_Homo sapiens_hsa003800.56496215
68TNF signaling pathway_Homo sapiens_hsa046680.56177953
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.55555100
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51802204
71VEGF signaling pathway_Homo sapiens_hsa043700.51127603
72Fatty acid degradation_Homo sapiens_hsa000710.49307133
73Morphine addiction_Homo sapiens_hsa050320.48740951
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46904790
75Protein export_Homo sapiens_hsa030600.45148410
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.44502357
77Pancreatic secretion_Homo sapiens_hsa049720.44023735
78Amphetamine addiction_Homo sapiens_hsa050310.43276504
79Homologous recombination_Homo sapiens_hsa034400.42700943
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39092639
81Hepatitis C_Homo sapiens_hsa051600.37516943
82African trypanosomiasis_Homo sapiens_hsa051430.37338131
83Phagosome_Homo sapiens_hsa041450.35535156
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35438339
85Legionellosis_Homo sapiens_hsa051340.32891088
86Peroxisome_Homo sapiens_hsa041460.31523118
87Type II diabetes mellitus_Homo sapiens_hsa049300.31210943
88Pyrimidine metabolism_Homo sapiens_hsa002400.30877637
89Endometrial cancer_Homo sapiens_hsa052130.28893596
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28529951
91Long-term potentiation_Homo sapiens_hsa047200.28510588
92Starch and sucrose metabolism_Homo sapiens_hsa005000.27415471
93Vitamin digestion and absorption_Homo sapiens_hsa049770.26133507
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25890991
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.25632090
96Insulin secretion_Homo sapiens_hsa049110.25259904
97cAMP signaling pathway_Homo sapiens_hsa040240.24676324
98Histidine metabolism_Homo sapiens_hsa003400.23223724
99Regulation of autophagy_Homo sapiens_hsa041400.23132120
100GABAergic synapse_Homo sapiens_hsa047270.22849337

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