RPS23P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.73550096
2translational termination (GO:0006415)8.32731569
3ribosomal small subunit assembly (GO:0000028)7.74748030
4ribosomal small subunit biogenesis (GO:0042274)7.37199314
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.13115609
6cotranslational protein targeting to membrane (GO:0006613)7.02657653
7protein targeting to ER (GO:0045047)6.97577358
8translational elongation (GO:0006414)6.86813324
9establishment of protein localization to endoplasmic reticulum (GO:0072599)6.69000743
10protein localization to endoplasmic reticulum (GO:0070972)6.59095865
11viral life cycle (GO:0019058)6.35588757
12cellular protein complex disassembly (GO:0043624)6.29526153
13nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.09570934
14energy coupled proton transport, down electrochemical gradient (GO:0015985)5.59718849
15ATP synthesis coupled proton transport (GO:0015986)5.59718849
16protein complex disassembly (GO:0043241)5.40551102
17translational initiation (GO:0006413)5.38954348
18ribosomal large subunit biogenesis (GO:0042273)5.11002320
19macromolecular complex disassembly (GO:0032984)5.09348880
20protein neddylation (GO:0045116)5.03228432
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.81698019
22protein targeting to membrane (GO:0006612)4.73112846
23chaperone-mediated protein transport (GO:0072321)4.55904231
24behavioral response to nicotine (GO:0035095)4.52823479
25translation (GO:0006412)4.52404128
26GTP biosynthetic process (GO:0006183)4.35821810
27nuclear-transcribed mRNA catabolic process (GO:0000956)4.27684581
28tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.07331587
29RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.07331587
30mRNA catabolic process (GO:0006402)4.04189899
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.92694230
32mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.80468760
33pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.78832173
34ribonucleoprotein complex biogenesis (GO:0022613)3.76829280
35UTP biosynthetic process (GO:0006228)3.71293246
36water-soluble vitamin biosynthetic process (GO:0042364)3.65814697
37RNA catabolic process (GO:0006401)3.65107909
38nonmotile primary cilium assembly (GO:0035058)3.61489767
39cellular component biogenesis (GO:0044085)3.58825390
40protein complex biogenesis (GO:0070271)3.58154828
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.53590606
42NADH dehydrogenase complex assembly (GO:0010257)3.53590606
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.53590606
44respiratory electron transport chain (GO:0022904)3.52618671
45electron transport chain (GO:0022900)3.50154604
46parturition (GO:0007567)3.48887014
47purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.47904986
48substrate-independent telencephalic tangential migration (GO:0021826)3.46207280
49substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.46207280
50UTP metabolic process (GO:0046051)3.42119583
51purine nucleoside triphosphate biosynthetic process (GO:0009145)3.41566387
52cell proliferation in forebrain (GO:0021846)3.40011437
53transmission of nerve impulse (GO:0019226)3.38736028
54mitochondrial respiratory chain complex assembly (GO:0033108)3.22864182
55ATP biosynthetic process (GO:0006754)3.20141778
56base-excision repair, AP site formation (GO:0006285)3.18945096
57pyrimidine nucleotide catabolic process (GO:0006244)3.18371952
58CTP metabolic process (GO:0046036)3.17404347
59CTP biosynthetic process (GO:0006241)3.17404347
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.13522425
61establishment of protein localization to membrane (GO:0090150)3.12426662
62pattern specification involved in kidney development (GO:0061004)3.12208074
63somite development (GO:0061053)3.07608785
64ribonucleoside triphosphate biosynthetic process (GO:0009201)3.06396642
65protein targeting (GO:0006605)3.01950121
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.96464609
67rRNA processing (GO:0006364)2.94364862
68tongue development (GO:0043586)2.91950031
69intra-S DNA damage checkpoint (GO:0031573)2.91033080
70DNA replication checkpoint (GO:0000076)2.90019753
71hydrogen ion transmembrane transport (GO:1902600)2.88344900
72rRNA metabolic process (GO:0016072)2.85790652
73dopamine transport (GO:0015872)2.83446379
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.81333689
75establishment of protein localization to organelle (GO:0072594)2.78498070
76pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.77379133
77pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.75332356
78guanosine-containing compound biosynthetic process (GO:1901070)2.75179313
79aldehyde catabolic process (GO:0046185)2.71615603
80auditory receptor cell differentiation (GO:0042491)2.67480046
81epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.66949008
82proton transport (GO:0015992)2.64948736
83pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.61499502
84pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.60825597
85antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.58875501
86hydrogen transport (GO:0006818)2.58834068
87neuron fate determination (GO:0048664)2.55568858
88telencephalon development (GO:0021537)2.53061229
89nucleoside triphosphate biosynthetic process (GO:0009142)2.52127063
90positive regulation of fatty acid transport (GO:2000193)2.51902305
91protein localization to membrane (GO:0072657)2.50015138
92segment specification (GO:0007379)2.49849734
93phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.48672127
94synaptic transmission, cholinergic (GO:0007271)2.48459523
95positive regulation of respiratory burst (GO:0060267)2.46824624
96short-term memory (GO:0007614)2.43414706
97respiratory chain complex IV assembly (GO:0008535)2.41926075
98detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.41215092
99pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.40598727
100maturation of SSU-rRNA (GO:0030490)10.1905243

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.94311073
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.02385592
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.29202750
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.20570748
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.13820924
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.96575910
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.94693926
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.89227423
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.87951171
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.67075278
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.64300205
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53325551
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48006504
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.29599098
15VDR_22108803_ChIP-Seq_LS180_Human2.25461105
16ZNF274_21170338_ChIP-Seq_K562_Hela2.03462823
17CREB1_15753290_ChIP-ChIP_HEK293T_Human1.96772317
18IRF1_19129219_ChIP-ChIP_H3396_Human1.95127392
19XRN2_22483619_ChIP-Seq_HELA_Human1.95091994
20VDR_23849224_ChIP-Seq_CD4+_Human1.86355832
21MYC_18940864_ChIP-ChIP_HL60_Human1.85335798
22MYC_19079543_ChIP-ChIP_MESCs_Mouse1.82805162
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.80163666
24TTF2_22483619_ChIP-Seq_HELA_Human1.78093741
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77193461
26ELK1_19687146_ChIP-ChIP_HELA_Human1.76445381
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70898144
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68591177
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68124456
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.67156332
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62867733
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57177998
33FOXP3_21729870_ChIP-Seq_TREG_Human1.55914752
34TP53_22573176_ChIP-Seq_HFKS_Human1.54717660
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50267129
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49710916
37SOX2_18555785_ChIP-Seq_MESCs_Mouse1.47350045
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.46944828
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.42916844
40CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.41475352
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38835219
42KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.37812453
43ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37011464
44GABP_19822575_ChIP-Seq_HepG2_Human1.36924313
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33170697
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.33124692
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.33065428
48SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.32736454
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32658109
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.31288157
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26242959
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25578427
53MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23299124
54ERA_21632823_ChIP-Seq_H3396_Human1.22407252
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22000880
56EWS_26573619_Chip-Seq_HEK293_Human1.21906304
57CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.21482174
58TAF2_19829295_ChIP-Seq_ESCs_Human1.19826191
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19201141
60YY1_22570637_ChIP-Seq_MALME-3M_Human1.18421262
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17428157
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.12885770
63NANOG_20526341_ChIP-Seq_ESCs_Human1.12424044
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12286609
65NCOR_22424771_ChIP-Seq_293T_Human1.11714933
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09233296
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07459913
68REST_21632747_ChIP-Seq_MESCs_Mouse1.06817812
69FUS_26573619_Chip-Seq_HEK293_Human1.05065108
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.04546791
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04117746
72MYC_19829295_ChIP-Seq_ESCs_Human1.03883693
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.03177680
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.02819405
75RNF2_27304074_Chip-Seq_NSC_Mouse1.01751272
76JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00868459
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.00796176
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.00137003
79AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99843048
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97977967
81P53_21459846_ChIP-Seq_SAOS-2_Human0.96859276
82CTCF_20526341_ChIP-Seq_ESCs_Human0.95665013
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93868688
84FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90540097
85FOXA1_25329375_ChIP-Seq_VCAP_Human0.90540097
86ERG_20517297_ChIP-Seq_VCAP_Human0.89962791
87AR_20517297_ChIP-Seq_VCAP_Human0.89303221
88ERG_21242973_ChIP-ChIP_JURKAT_Human0.89001884
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88828650
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87352833
91P300_19829295_ChIP-Seq_ESCs_Human0.86404106
92SOX2_18692474_ChIP-Seq_MEFs_Mouse0.86075886
93TDRD3_21172665_ChIP-Seq_MCF-7_Human0.85788216
94E2F1_18555785_ChIP-Seq_MESCs_Mouse0.84213327
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.84049413
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83571896
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.81437815
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81110631
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80910183
100ER_23166858_ChIP-Seq_MCF-7_Human0.80232593

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.68080998
2MP0006292_abnormal_olfactory_placode5.33347714
3MP0001529_abnormal_vocalization2.97765098
4MP0003122_maternal_imprinting2.83314647
5MP0008789_abnormal_olfactory_epithelium2.65964557
6MP0003787_abnormal_imprinting2.64080177
7MP0008877_abnormal_DNA_methylation2.43032961
8MP0005499_abnormal_olfactory_system2.26575555
9MP0005394_taste/olfaction_phenotype2.26575555
10MP0003136_yellow_coat_color2.10622244
11MP0002653_abnormal_ependyma_morphology2.07832762
12MP0005377_hearing/vestibular/ear_phenot2.05135567
13MP0003878_abnormal_ear_physiology2.05135567
14MP0002138_abnormal_hepatobiliary_system2.01755650
15MP0002160_abnormal_reproductive_system1.99207594
16MP0002163_abnormal_gland_morphology1.97788116
17MP0001835_abnormal_antigen_presentation1.96510656
18MP0001293_anophthalmia1.95458516
19MP0003567_abnormal_fetal_cardiomyocyte1.91000217
20MP0004142_abnormal_muscle_tone1.88346749
21MP0003195_calcinosis1.84022561
22MP0001485_abnormal_pinna_reflex1.81834104
23MP0003121_genomic_imprinting1.80554369
24MP0000049_abnormal_middle_ear1.70771493
25MP0002102_abnormal_ear_morphology1.70725796
26MP0001348_abnormal_lacrimal_gland1.66121113
27MP0003123_paternal_imprinting1.65787238
28MP0000372_irregular_coat_pigmentation1.49955492
29MP0008875_abnormal_xenobiotic_pharmacok1.49678545
30MP0004885_abnormal_endolymph1.48674451
31MP0001440_abnormal_grooming_behavior1.46275420
32MP0000566_synostosis1.45550732
33MP0006276_abnormal_autonomic_nervous1.42738417
34MP0000778_abnormal_nervous_system1.41131959
35MP0005389_reproductive_system_phenotype1.40940297
36MP0002938_white_spotting1.39584456
37MP0002837_dystrophic_cardiac_calcinosis1.34831639
38MP0003011_delayed_dark_adaptation1.34267907
39MP0002736_abnormal_nociception_after1.33720935
40MP0005551_abnormal_eye_electrophysiolog1.32605925
41MP0003646_muscle_fatigue1.27432529
42MP0002272_abnormal_nervous_system1.27120006
43MP0004145_abnormal_muscle_electrophysio1.23001538
44MP0003880_abnormal_central_pattern1.20732651
45MP0004147_increased_porphyrin_level1.19734454
46MP0003879_abnormal_hair_cell1.17286970
47MP0003806_abnormal_nucleotide_metabolis1.16870846
48MP0004742_abnormal_vestibular_system1.14706449
49MP0002557_abnormal_social/conspecific_i1.14687897
50MP0005195_abnormal_posterior_eye1.13597483
51MP0001968_abnormal_touch/_nociception1.13132282
52MP0000631_abnormal_neuroendocrine_gland1.12347955
53MP0001502_abnormal_circadian_rhythm1.11870506
54MP0003186_abnormal_redox_activity1.10374133
55MP0006072_abnormal_retinal_apoptosis1.10247711
56MP0008872_abnormal_physiological_respon1.07748337
57MP0001986_abnormal_taste_sensitivity1.07293506
58MP0002277_abnormal_respiratory_mucosa1.02460469
59MP0000026_abnormal_inner_ear1.01807760
60MP0001984_abnormal_olfaction1.00339897
61MP0004133_heterotaxia0.98665978
62MP0003936_abnormal_reproductive_system0.98204658
63MP0003252_abnormal_bile_duct0.97657120
64MP0000955_abnormal_spinal_cord0.97512755
65MP0001905_abnormal_dopamine_level0.97230683
66MP0009745_abnormal_behavioral_response0.97002740
67MP0002210_abnormal_sex_determination0.96691444
68MP0001970_abnormal_pain_threshold0.96201469
69MP0002638_abnormal_pupillary_reflex0.95039298
70MP0002233_abnormal_nose_morphology0.94663837
71MP0002095_abnormal_skin_pigmentation0.94609271
72MP0002733_abnormal_thermal_nociception0.94587268
73MP0001919_abnormal_reproductive_system0.93790004
74MP0005379_endocrine/exocrine_gland_phen0.93251921
75MP0002752_abnormal_somatic_nervous0.91147561
76MP0010030_abnormal_orbit_morphology0.90921538
77MP0008058_abnormal_DNA_repair0.90502296
78MP0005408_hypopigmentation0.89357619
79MP0002876_abnormal_thyroid_physiology0.88322349
80MP0008775_abnormal_heart_ventricle0.88122904
81MP0001486_abnormal_startle_reflex0.86825349
82MP0002928_abnormal_bile_duct0.86008227
83MP0003938_abnormal_ear_development0.85800577
84MP0005084_abnormal_gallbladder_morpholo0.85274687
85MP0002234_abnormal_pharynx_morphology0.83322640
86MP0001286_abnormal_eye_development0.82332677
87MP0001963_abnormal_hearing_physiology0.81450705
88MP0000613_abnormal_salivary_gland0.79003161
89MP0002572_abnormal_emotion/affect_behav0.73638384
90MP0003937_abnormal_limbs/digits/tail_de0.73172040
91MP0005645_abnormal_hypothalamus_physiol0.73164508
92MP0004924_abnormal_behavior0.72715084
93MP0005386_behavior/neurological_phenoty0.72715084
94MP0001663_abnormal_digestive_system0.72215078
95MP0005671_abnormal_response_to0.70823883
96MP0005410_abnormal_fertilization0.69744819
97MP0002067_abnormal_sensory_capabilities0.69509005
98MP0001145_abnormal_male_reproductive0.68737176
99MP0001119_abnormal_female_reproductive0.68026786
100MP0002184_abnormal_innervation0.67388858

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.04142887
2Chronic otitis media (HP:0000389)5.15754613
3Abnormality of cells of the erythroid lineage (HP:0012130)4.72300180
4Macrocytic anemia (HP:0001972)4.24134510
5Septo-optic dysplasia (HP:0100842)4.12910555
6Acute necrotizing encephalopathy (HP:0006965)4.00333181
7Nasal polyposis (HP:0100582)3.95896547
8Chronic sinusitis (HP:0011109)3.80012419
9Abnormal number of erythroid precursors (HP:0012131)3.72676847
10Abnormal mitochondria in muscle tissue (HP:0008316)3.54998253
11Abnormal rod and cone electroretinograms (HP:0008323)3.43270226
12Acute encephalopathy (HP:0006846)3.40159538
13Colon cancer (HP:0003003)3.37683783
14Mitochondrial inheritance (HP:0001427)3.36861761
15Medial flaring of the eyebrow (HP:0010747)3.31430855
16Molar tooth sign on MRI (HP:0002419)3.20135562
17Abnormality of midbrain morphology (HP:0002418)3.20135562
18Lipid accumulation in hepatocytes (HP:0006561)3.19216829
19Absent rod-and cone-mediated responses on ERG (HP:0007688)3.17253131
20Progressive macrocephaly (HP:0004481)3.15408251
21Pallor (HP:0000980)3.15065546
22Increased hepatocellular lipid droplets (HP:0006565)3.08797064
23Increased CSF lactate (HP:0002490)3.06201188
24Abnormality of the nasal mucosa (HP:0000433)3.04061717
25Pancreatic fibrosis (HP:0100732)2.96080585
26Congenital stationary night blindness (HP:0007642)2.89205393
27Nephronophthisis (HP:0000090)2.81640823
28Absent thumb (HP:0009777)2.80155858
29Rib fusion (HP:0000902)2.71246686
30Type II lissencephaly (HP:0007260)2.69640949
31Renal Fanconi syndrome (HP:0001994)2.66351052
32Hypothermia (HP:0002045)2.59801505
333-Methylglutaconic aciduria (HP:0003535)2.57844124
34Hepatocellular necrosis (HP:0001404)2.55719384
35Abolished electroretinogram (ERG) (HP:0000550)2.53051360
36Sclerocornea (HP:0000647)2.49749194
37Stenosis of the external auditory canal (HP:0000402)2.47576114
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.46010696
39Abnormality of the labia minora (HP:0012880)2.45208021
40Pancreatic cysts (HP:0001737)2.41515359
41True hermaphroditism (HP:0010459)2.40906688
42Cerebral edema (HP:0002181)2.40109347
43Gait imbalance (HP:0002141)2.39735066
44Bony spicule pigmentary retinopathy (HP:0007737)2.37158418
45Adrenal hypoplasia (HP:0000835)2.33626242
46Aplasia/Hypoplasia of the spleen (HP:0010451)2.32968490
47Asplenia (HP:0001746)2.32679495
48Hepatic necrosis (HP:0002605)2.32223008
49Recurrent bronchitis (HP:0002837)2.32099126
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.31965570
51Absent septum pellucidum (HP:0001331)2.31298611
52Optic disc pallor (HP:0000543)2.31196711
53Congenital primary aphakia (HP:0007707)2.31117213
54Optic nerve hypoplasia (HP:0000609)2.30762841
55Hypoplasia of the radius (HP:0002984)2.23746578
56Abnormality of renal resorption (HP:0011038)2.23686578
57Abnormality of alanine metabolism (HP:0010916)2.20316472
58Hyperalaninemia (HP:0003348)2.20316472
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20316472
60Maternal diabetes (HP:0009800)2.20098237
61Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.15810831
62Pendular nystagmus (HP:0012043)2.15419808
63Growth hormone deficiency (HP:0000824)2.12861501
64Abnormality of the renal medulla (HP:0100957)2.11775355
65Nephrogenic diabetes insipidus (HP:0009806)2.10035177
66Respiratory difficulties (HP:0002880)2.09132163
67Cerebellar dysplasia (HP:0007033)2.07382442
68Forearm undergrowth (HP:0009821)2.06305023
69Depressed nasal ridge (HP:0000457)2.05926057
70Increased serum lactate (HP:0002151)2.04879417
71Hypoplasia of the ulna (HP:0003022)2.04618951
72Deep palmar crease (HP:0006191)2.03696244
73Increased intramyocellular lipid droplets (HP:0012240)2.00457764
74Anophthalmia (HP:0000528)1.96893563
75Hyperthyroidism (HP:0000836)1.96551777
76Impulsivity (HP:0100710)1.93941793
77Oligodactyly (hands) (HP:0001180)1.92691906
78Postaxial foot polydactyly (HP:0001830)1.91294108
7911 pairs of ribs (HP:0000878)1.91145393
80Congenital, generalized hypertrichosis (HP:0004540)1.89218293
81Exertional dyspnea (HP:0002875)1.87799864
82Triphalangeal thumb (HP:0001199)1.87586283
83Lethargy (HP:0001254)1.86977307
84Increased muscle lipid content (HP:0009058)1.84746076
85Type 2 muscle fiber atrophy (HP:0003554)1.84244728
86Horseshoe kidney (HP:0000085)1.83664365
87Oligodactyly (HP:0012165)1.82543494
88Lactic acidosis (HP:0003128)1.82254319
89Leukodystrophy (HP:0002415)1.81616196
90Supernumerary spleens (HP:0009799)1.81207800
91Abnormal number of incisors (HP:0011064)1.78984006
92Aplasia/Hypoplasia of the ulna (HP:0006495)1.78734474
93Polydipsia (HP:0001959)1.78476086
94Abnormal drinking behavior (HP:0030082)1.78476086
95Porencephaly (HP:0002132)1.77319292
96Vaginal atresia (HP:0000148)1.76786827
97Postaxial hand polydactyly (HP:0001162)1.75714487
98Myokymia (HP:0002411)1.75419328
99Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75398052
100Decreased central vision (HP:0007663)1.73891776

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K136.00596336
2TLK14.25637890
3MAP3K93.30322670
4WNK42.81514210
5ARAF2.81094354
6ZAK2.20564168
7TXK2.10851908
8NEK12.09557916
9ADRBK21.95011632
10BRAF1.89573038
11BCKDK1.89197805
12PIK3CA1.89040787
13TAOK31.68881153
14DYRK21.63579842
15EPHB21.49516088
16VRK21.49036759
17CDK191.48418365
18GRK11.45800669
19BMPR1B1.45555940
20WNK31.43977942
21CDC71.43112619
22NUAK11.39029703
23PLK41.38241251
24NME21.31211223
25STK391.27212053
26STK161.24068721
27EPHA41.19250101
28MOS1.15671211
29TIE11.15226351
30LRRK21.13145157
31NEK21.11519262
32ILK1.10790861
33PINK11.09920313
34PDK21.07499388
35TRIM281.03566519
36FRK0.99375995
37PRKCG0.95898262
38NME10.93361270
39IKBKB0.91905421
40BTK0.89228459
41PRKCQ0.89209680
42PLK10.88174084
43BMPR20.84190052
44VRK10.77413969
45MARK10.76241228
46AURKB0.75911187
47PASK0.75040378
48CAMK10.74720267
49DAPK30.73154398
50CSNK2A20.72370373
51PLK30.70223399
52MAP3K40.69387126
53CAMKK20.67442453
54ADRBK10.67200885
55MAP3K70.67168171
56STK110.67032210
57ATR0.66866816
58MAPK130.64941515
59ABL20.63109391
60INSRR0.62920447
61LIMK10.62535994
62TAF10.59848243
63AURKA0.59844307
64PBK0.59528119
65DYRK1B0.57863259
66WNK10.56802436
67SIK20.55639658
68CSNK1E0.55512132
69TNIK0.55496689
70CSNK2A10.55094605
71PRKACA0.53936385
72TYRO30.53743053
73PAK30.50910743
74MAP3K140.50553305
75STK38L0.49675067
76CHEK20.49267085
77PRKCZ0.49020575
78TGFBR10.47998510
79PLK20.47989074
80CASK0.47212800
81CDK80.47004177
82MAPK150.46765947
83OXSR10.46611286
84MAP4K20.46029881
85MAP4K10.45741170
86BRSK10.45618057
87TEC0.42269965
88MKNK20.42175144
89CHUK0.41965481
90OBSCN0.41829210
91SGK10.40725093
92STK30.40424716
93CSNK1G20.40287692
94TSSK60.40003381
95CAMKK10.38440277
96TESK10.37996585
97PIM20.37801529
98CSNK1A10.36971046
99MAP2K20.35619126
100CSNK1G30.34747505

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.19059557
2Oxidative phosphorylation_Homo sapiens_hsa001904.19637751
3Parkinsons disease_Homo sapiens_hsa050123.41161898
4Huntingtons disease_Homo sapiens_hsa050162.46678482
5Linoleic acid metabolism_Homo sapiens_hsa005912.30518344
6Alzheimers disease_Homo sapiens_hsa050102.27707087
7Cardiac muscle contraction_Homo sapiens_hsa042602.25122179
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.17021104
9Proteasome_Homo sapiens_hsa030502.14680967
10Asthma_Homo sapiens_hsa053102.14345785
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.12730365
12Homologous recombination_Homo sapiens_hsa034402.12136875
13RNA polymerase_Homo sapiens_hsa030202.09673619
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88274267
15Sulfur relay system_Homo sapiens_hsa041221.87768242
16Protein export_Homo sapiens_hsa030601.69682506
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.59150684
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55982712
19Mismatch repair_Homo sapiens_hsa034301.51843459
20Fanconi anemia pathway_Homo sapiens_hsa034601.47274444
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.46264655
22Allograft rejection_Homo sapiens_hsa053301.39641044
23RNA degradation_Homo sapiens_hsa030181.39471874
24Pyrimidine metabolism_Homo sapiens_hsa002401.37962389
25Basal transcription factors_Homo sapiens_hsa030221.35200712
26Autoimmune thyroid disease_Homo sapiens_hsa053201.31834771
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30254353
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27080899
29Ether lipid metabolism_Homo sapiens_hsa005651.26546838
30Fatty acid degradation_Homo sapiens_hsa000711.25708624
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19207065
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16978363
33Collecting duct acid secretion_Homo sapiens_hsa049661.14354653
34Nitrogen metabolism_Homo sapiens_hsa009101.14160695
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10953623
36Fat digestion and absorption_Homo sapiens_hsa049751.10906396
37Arachidonic acid metabolism_Homo sapiens_hsa005901.10484215
38DNA replication_Homo sapiens_hsa030301.10458849
39Phototransduction_Homo sapiens_hsa047441.05015627
40One carbon pool by folate_Homo sapiens_hsa006701.03933384
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03902415
42Nucleotide excision repair_Homo sapiens_hsa034201.03810860
43Spliceosome_Homo sapiens_hsa030401.01219900
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99100699
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95204370
46Tryptophan metabolism_Homo sapiens_hsa003800.85936567
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84166856
48Type I diabetes mellitus_Homo sapiens_hsa049400.79989795
49Graft-versus-host disease_Homo sapiens_hsa053320.79259015
50Olfactory transduction_Homo sapiens_hsa047400.77729569
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75196100
52Propanoate metabolism_Homo sapiens_hsa006400.73189613
53Caffeine metabolism_Homo sapiens_hsa002320.70829827
54RNA transport_Homo sapiens_hsa030130.69827831
55Nicotine addiction_Homo sapiens_hsa050330.69757420
56Base excision repair_Homo sapiens_hsa034100.68503552
57Metabolic pathways_Homo sapiens_hsa011000.68302152
58Purine metabolism_Homo sapiens_hsa002300.66464753
59Peroxisome_Homo sapiens_hsa041460.66161635
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.65372970
61Systemic lupus erythematosus_Homo sapiens_hsa053220.64875736
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63505723
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61480863
64Chemical carcinogenesis_Homo sapiens_hsa052040.60881677
65Butanoate metabolism_Homo sapiens_hsa006500.60518031
66Hedgehog signaling pathway_Homo sapiens_hsa043400.55753308
67Basal cell carcinoma_Homo sapiens_hsa052170.55262479
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.53248942
69Steroid biosynthesis_Homo sapiens_hsa001000.51929922
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48929499
71Fatty acid metabolism_Homo sapiens_hsa012120.48878699
72Rheumatoid arthritis_Homo sapiens_hsa053230.48519044
73Antigen processing and presentation_Homo sapiens_hsa046120.47772097
74Retinol metabolism_Homo sapiens_hsa008300.47639300
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45196960
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.44588511
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41010768
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.38304522
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37346130
80Regulation of autophagy_Homo sapiens_hsa041400.36284503
81p53 signaling pathway_Homo sapiens_hsa041150.36203560
82Folate biosynthesis_Homo sapiens_hsa007900.31571133
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31443908
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30911856
85Pyruvate metabolism_Homo sapiens_hsa006200.29714028
86Vitamin B6 metabolism_Homo sapiens_hsa007500.29442865
87Ovarian steroidogenesis_Homo sapiens_hsa049130.29135789
88Glutathione metabolism_Homo sapiens_hsa004800.27574123
89Glycerolipid metabolism_Homo sapiens_hsa005610.26486663
90Notch signaling pathway_Homo sapiens_hsa043300.24318833
91Tyrosine metabolism_Homo sapiens_hsa003500.24244693
92Hippo signaling pathway_Homo sapiens_hsa043900.24079110
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23991045
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22993964
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.19301349
96Taste transduction_Homo sapiens_hsa047420.17931976
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.16848454
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.16129474
99Sulfur metabolism_Homo sapiens_hsa009200.15454628
100beta-Alanine metabolism_Homo sapiens_hsa004100.14657283

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