ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sphingosine metabolic process (GO:0006670)	7.16222447
2	diol metabolic process (GO:0034311)	6.38466061
3	sphingoid metabolic process (GO:0046519)	5.96809048
4	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	5.37199698
5	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	4.82245492
6	DNA methylation involved in gamete generation (GO:0043046)	4.72293230
7	ribonucleoprotein complex disassembly (GO:0032988)	4.62808579
8	negative regulation of cell cycle G2/M phase transition (GO:1902750)	4.52487309
9	lipopolysaccharide biosynthetic process (GO:0009103)	4.51410637
10	auditory receptor cell differentiation (GO:0042491)	4.42678552
11	translational termination (GO:0006415)	4.37859978
12	viral transcription (GO:0019083)	4.36822440
13	central nervous system myelination (GO:0022010)	4.22820547
14	axon ensheathment in central nervous system (GO:0032291)	4.22820547
15	protein-chromophore linkage (GO:0018298)	4.11734166
16	sulfate transmembrane transport (GO:1902358)	4.11360764
17	organelle disassembly (GO:1903008)	4.02728700
18	maturation of SSU-rRNA (GO:0030490)	3.96060903
19	ribosomal small subunit biogenesis (GO:0042274)	3.88403501
20	regulation of meiosis I (GO:0060631)	3.87457996
21	nonmotile primary cilium assembly (GO:0035058)	3.86869210
22	piRNA metabolic process (GO:0034587)	3.85445393
23	lipopolysaccharide metabolic process (GO:0008653)	3.80686651
24	behavioral response to nicotine (GO:0035095)	3.73393645
25	regulation of protein glycosylation (GO:0060049)	3.68386632
26	neuron fate determination (GO:0048664)	3.66668340
27	ovulation cycle (GO:0042698)	3.63078171
28	DNA deamination (GO:0045006)	3.57984526
29	positive regulation of developmental pigmentation (GO:0048087)	3.56726511
30	sulfate transport (GO:0008272)	3.51099433
31	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.47537819
32	L-phenylalanine catabolic process (GO:0006559)	3.47537819
33	microtubule severing (GO:0051013)	3.43067881
34	meiotic chromosome segregation (GO:0045132)	3.43052206
35	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.42619183
36	cotranslational protein targeting to membrane (GO:0006613)	3.37017230
37	viral life cycle (GO:0019058)	3.34663413
38	protein targeting to ER (GO:0045047)	3.33976485
39	tachykinin receptor signaling pathway (GO:0007217)	3.33354930
40	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.33068516
41	regulation of pigment cell differentiation (GO:0050932)	3.33034566
42	intraciliary transport (GO:0042073)	3.32401007
43	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.31388810
44	negative regulation of glycoprotein biosynthetic process (GO:0010561)	3.30407868
45	translational elongation (GO:0006414)	3.27976746
46	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.25985590
47	cellular protein complex disassembly (GO:0043624)	3.24658917
48	respiratory tube development (GO:0030323)	3.24442908
49	tongue development (GO:0043586)	3.24193425
50	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.23346128
51	ribosomal small subunit assembly (GO:0000028)	3.20568971
52	serotonin receptor signaling pathway (GO:0007210)	3.20546783
53	heme transport (GO:0015886)	3.19477957
54	pattern specification involved in kidney development (GO:0061004)	3.16047772
55	GTP biosynthetic process (GO:0006183)	3.15530382
56	protein localization to endoplasmic reticulum (GO:0070972)	3.10874125
57	mannosylation (GO:0097502)	3.10590773
58	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.00233699
59	cell proliferation in forebrain (GO:0021846)	2.97067168
60	paraxial mesoderm development (GO:0048339)	2.92384813
61	kidney morphogenesis (GO:0060993)	2.92034903
62	aromatic amino acid family catabolic process (GO:0009074)	2.91280631
63	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.87208460
64	macromolecular complex disassembly (GO:0032984)	2.85966980
65	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.83600015
66	metanephric tubule development (GO:0072170)	2.79924574
67	metanephric nephron tubule development (GO:0072234)	2.79924574
68	lens fiber cell development (GO:0070307)	2.79905981
69	regulation of neuroblast proliferation (GO:1902692)	2.79138973
70	telencephalon development (GO:0021537)	2.77032050
71	epithelial cilium movement (GO:0003351)	2.75870817
72	head development (GO:0060322)	2.75238757
73	reflex (GO:0060004)	2.74018937
74	protein complex disassembly (GO:0043241)	2.72467622
75	regulation of mesoderm development (GO:2000380)	2.71701020
76	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.71139304
77	neuronal stem cell maintenance (GO:0097150)	2.70862033
78	uterus development (GO:0060065)	2.69744314
79	centriole replication (GO:0007099)	2.69348971
80	positive regulation of meiosis (GO:0045836)	2.67038773
81	pantothenate metabolic process (GO:0015939)	2.66513229
82	UTP biosynthetic process (GO:0006228)	2.65581809
83	cardiac left ventricle morphogenesis (GO:0003214)	2.65477915
84	somite development (GO:0061053)	2.65127437
85	iron coordination entity transport (GO:1901678)	2.64419687
86	inner ear receptor cell development (GO:0060119)	2.63506952
87	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.62019455
88	mechanosensory behavior (GO:0007638)	2.61655753
89	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.61543569
90	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.61543569
91	regulation of cilium movement (GO:0003352)	2.61361973
92	postsynaptic membrane organization (GO:0001941)	2.60982342
93	reciprocal DNA recombination (GO:0035825)	2.59855473
94	reciprocal meiotic recombination (GO:0007131)	2.59855473
95	glycerol metabolic process (GO:0006071)	2.58285524
96	negative regulation of stem cell proliferation (GO:2000647)	2.57569919
97	indolalkylamine metabolic process (GO:0006586)	2.56311433
98	L-phenylalanine metabolic process (GO:0006558)	2.55409421
99	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.55409421
100	regulation of transmission of nerve impulse (GO:0051969)	2.51364339

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.42467614
2	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.08678649
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.08458119
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.98810959
5	VDR_22108803_ChIP-Seq_LS180_Human	2.75809837
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.52525955
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.47405753
8	AR_21572438_ChIP-Seq_LNCaP_Human	2.36424776
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.04263512
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.98914924
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.97819021
12	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.90916755
13	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.84974454
14	P300_19829295_ChIP-Seq_ESCs_Human	1.83909617
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.80642322
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.80331058
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.78962854
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.66231638
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.65811900
20	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.64728893
21	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.63762051
22	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.58183887
23	REST_21632747_ChIP-Seq_MESCs_Mouse	1.56992292
24	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.56912506
25	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.53817923
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53453394
27	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53200556
28	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.53200556
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.52349096
30	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.52311356
31	GBX2_23144817_ChIP-Seq_PC3_Human	1.51835747
32	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.50732134
33	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.49276078
34	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.48430584
35	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.47073555
36	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.43808548
37	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.42698832
38	EWS_26573619_Chip-Seq_HEK293_Human	1.41162681
39	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.40242014
40	EGR1_19032775_ChIP-ChIP_M12_Human	1.36704828
41	FUS_26573619_Chip-Seq_HEK293_Human	1.34905520
42	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.34871446
43	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.34451513
44	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.34262396
45	HOXB7_26014856_ChIP-Seq_BT474_Human	1.33520143
46	ER_23166858_ChIP-Seq_MCF-7_Human	1.32458015
47	NCOR_22424771_ChIP-Seq_293T_Human	1.31465849
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31022991
49	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.28725181
50	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.28487533
51	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.28442636
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.28434473
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.28434473
54	TCF4_23295773_ChIP-Seq_U87_Human	1.28408969
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.26898198
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26898198
57	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.25538599
58	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.23754541
59	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.22858499
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22753450
61	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.22486516
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19418989
63	STAT3_23295773_ChIP-Seq_U87_Human	1.19122983
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17504529
65	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.16063882
66	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.15826994
67	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.15105528
68	AR_25329375_ChIP-Seq_VCAP_Human	1.14811696
69	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.13336739
70	MYC_19829295_ChIP-Seq_ESCs_Human	1.10746822
71	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.10577440
72	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.09153332
73	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.08542383
74	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.08400618
75	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08212706
76	RNF2_27304074_Chip-Seq_NSC_Mouse	1.07869805
77	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.07816354
78	TAF2_19829295_ChIP-Seq_ESCs_Human	1.07460586
79	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.07102429
80	TCF4_22108803_ChIP-Seq_LS180_Human	1.05624250
81	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.05005218
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04585073
83	TP53_22573176_ChIP-Seq_HFKS_Human	1.04185308
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04070824
85	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04070824
86	MYC_18940864_ChIP-ChIP_HL60_Human	1.03437596
87	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.02746140
88	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.02746140
89	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01484711
90	NANOG_20526341_ChIP-Seq_ESCs_Human	1.00558634
91	TAF15_26573619_Chip-Seq_HEK293_Human	1.00394524
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99539883
93	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.98288385
94	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98073689
95	OCT4_20526341_ChIP-Seq_ESCs_Human	0.97717473
96	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97161604
97	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.95220652
98	SMAD4_21799915_ChIP-Seq_A2780_Human	0.94872128
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.94416423
100	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.94225142

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	6.12525479
2	MP0003136_yellow_coat_color	5.54047942
3	MP0002653_abnormal_ependyma_morphology	5.22732291
4	MP0005171_absent_coat_pigmentation	3.89124776
5	MP0009379_abnormal_foot_pigmentation	3.53022639
6	MP0003646_muscle_fatigue	2.95760251
7	MP0000569_abnormal_digit_pigmentation	2.64645223
8	MP0006292_abnormal_olfactory_placode	2.64023720
9	MP0003122_maternal_imprinting	2.45076530
10	MP0003890_abnormal_embryonic-extraembry	2.44286355
11	MP0008789_abnormal_olfactory_epithelium	2.31367381
12	MP0005646_abnormal_pituitary_gland	2.26426421
13	MP0003879_abnormal_hair_cell	2.19857792
14	MP0002102_abnormal_ear_morphology	2.15265444
15	MP0003787_abnormal_imprinting	2.14599630
16	MP0002938_white_spotting	2.08811544
17	MP0001984_abnormal_olfaction	2.00585908
18	MP0008877_abnormal_DNA_methylation	1.86815654
19	MP0003045_fibrosis	1.77086080
20	MP0005499_abnormal_olfactory_system	1.75916188
21	MP0005394_taste/olfaction_phenotype	1.75916188
22	MP0003121_genomic_imprinting	1.71067152
23	MP0010030_abnormal_orbit_morphology	1.60292616
24	MP0003123_paternal_imprinting	1.55794968
25	MP0001529_abnormal_vocalization	1.54405486
26	MP0005645_abnormal_hypothalamus_physiol	1.53802033
27	MP0000778_abnormal_nervous_system	1.50352338
28	MP0002272_abnormal_nervous_system	1.48609954
29	MP0002095_abnormal_skin_pigmentation	1.46373469
30	MP0001486_abnormal_startle_reflex	1.45466440
31	MP0003878_abnormal_ear_physiology	1.44135025
32	MP0005377_hearing/vestibular/ear_phenot	1.44135025
33	MP0006072_abnormal_retinal_apoptosis	1.41449670
34	MP0004147_increased_porphyrin_level	1.41426651
35	MP0003195_calcinosis	1.38843033
36	MP0004381_abnormal_hair_follicle	1.37212582
37	MP0004142_abnormal_muscle_tone	1.36914708
38	MP0005670_abnormal_white_adipose	1.36182088
39	MP0002736_abnormal_nociception_after	1.33613551
40	MP0001968_abnormal_touch/_nociception	1.32103072
41	MP0002138_abnormal_hepatobiliary_system	1.30896658
42	MP0000026_abnormal_inner_ear	1.29946936
43	MP0006276_abnormal_autonomic_nervous	1.26930631
44	MP0005085_abnormal_gallbladder_physiolo	1.26540655
45	MP0005551_abnormal_eye_electrophysiolog	1.21760149
46	MP0000049_abnormal_middle_ear	1.20651747
47	MP0004133_heterotaxia	1.19055976
48	MP0008875_abnormal_xenobiotic_pharmacok	1.17459920
49	MP0009046_muscle_twitch	1.15407985
50	MP0009745_abnormal_behavioral_response	1.10597688
51	MP0000372_irregular_coat_pigmentation	1.07364552
52	MP0005195_abnormal_posterior_eye	1.05837190
53	MP0003937_abnormal_limbs/digits/tail_de	1.03661128
54	MP0002557_abnormal_social/conspecific_i	1.02326919
55	MP0002163_abnormal_gland_morphology	1.01731889
56	MP0001293_anophthalmia	1.01128401
57	MP0002064_seizures	0.99899513
58	MP0005248_abnormal_Harderian_gland	0.99606131
59	MP0001485_abnormal_pinna_reflex	0.98192094
60	MP0002160_abnormal_reproductive_system	0.97053077
61	MP0001286_abnormal_eye_development	0.96799422
62	MP0005423_abnormal_somatic_nervous	0.96661639
63	MP0005075_abnormal_melanosome_morpholog	0.95910188
64	MP0008872_abnormal_physiological_respon	0.95451494
65	MP0001970_abnormal_pain_threshold	0.91696865
66	MP0002752_abnormal_somatic_nervous	0.91360897
67	MP0005174_abnormal_tail_pigmentation	0.90649369
68	MP0003137_abnormal_impulse_conducting	0.90167740
69	MP0002572_abnormal_emotion/affect_behav	0.88794132
70	MP0001963_abnormal_hearing_physiology	0.88425783
71	MP0002168_other_aberrant_phenotype	0.85924883
72	MP0004885_abnormal_endolymph	0.85675301
73	MP0000427_abnormal_hair_cycle	0.85276883
74	MP0003880_abnormal_central_pattern	0.83841999
75	MP0005253_abnormal_eye_physiology	0.80673272
76	MP0002233_abnormal_nose_morphology	0.80254104
77	MP0000631_abnormal_neuroendocrine_gland	0.78469482
78	MP0002733_abnormal_thermal_nociception	0.78257314
79	MP0001324_abnormal_eye_pigmentation	0.76886548
80	MP0002067_abnormal_sensory_capabilities	0.74579769
81	MP0003635_abnormal_synaptic_transmissio	0.74198938
82	MP0004742_abnormal_vestibular_system	0.74196073
83	MP0002277_abnormal_respiratory_mucosa	0.74114486
84	MP0000955_abnormal_spinal_cord	0.71811745
85	MP0002184_abnormal_innervation	0.70686253
86	MP0002229_neurodegeneration	0.69399523
87	MP0003315_abnormal_perineum_morphology	0.69304582
88	MP0002882_abnormal_neuron_morphology	0.68652900
89	MP0002063_abnormal_learning/memory/cond	0.68262728
90	MP0001501_abnormal_sleep_pattern	0.67902055
91	MP0002876_abnormal_thyroid_physiology	0.66156341
92	MP0002735_abnormal_chemical_nociception	0.65696256
93	MP0001440_abnormal_grooming_behavior	0.65009048
94	MP0009053_abnormal_anal_canal	0.62914782
95	MP0002210_abnormal_sex_determination	0.62334030
96	MP0001986_abnormal_taste_sensitivity	0.61443163
97	MP0002075_abnormal_coat/hair_pigmentati	0.61195998
98	MP0003755_abnormal_palate_morphology	0.59638995
99	MP0005386_behavior/neurological_phenoty	0.59374542
100	MP0004924_abnormal_behavior	0.59374542

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	5.94620876
2	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	4.66802231
3	Colon cancer (HP:0003003)	4.48497150
4	Amelogenesis imperfecta (HP:0000705)	4.35161117
5	Pancreatic cysts (HP:0001737)	4.34548893
6	Pancreatic fibrosis (HP:0100732)	4.26850370
7	Parakeratosis (HP:0001036)	4.07498478
8	Type II lissencephaly (HP:0007260)	3.79544050
9	True hermaphroditism (HP:0010459)	3.75245393
10	Reticulocytopenia (HP:0001896)	3.58654761
11	Chronic hepatic failure (HP:0100626)	3.52530672
12	Nephronophthisis (HP:0000090)	3.46005141
13	Severe visual impairment (HP:0001141)	3.41131033
14	Abnormality of cells of the erythroid lineage (HP:0012130)	3.37274052
15	Abnormality of midbrain morphology (HP:0002418)	3.34715742
16	Molar tooth sign on MRI (HP:0002419)	3.34715742
17	Pendular nystagmus (HP:0012043)	3.23158225
18	Cerebellar dysplasia (HP:0007033)	3.22494799
19	Dialeptic seizures (HP:0011146)	3.15001809
20	Abnormality of the renal medulla (HP:0100957)	3.12190119
21	Enlarged kidneys (HP:0000105)	2.92868216
22	Cystic liver disease (HP:0006706)	2.80019705
23	Abnormal number of erythroid precursors (HP:0012131)	2.79656796
24	Aplastic anemia (HP:0001915)	2.76522241
25	Sclerocornea (HP:0000647)	2.72454419
26	Focal seizures (HP:0007359)	2.70732656
27	Congenital ichthyosiform erythroderma (HP:0007431)	2.70341973
28	Anencephaly (HP:0002323)	2.61219444
29	Rectal prolapse (HP:0002035)	2.60452885
30	Medial flaring of the eyebrow (HP:0010747)	2.60080799
31	Stomatitis (HP:0010280)	2.57735082
32	Acanthocytosis (HP:0001927)	2.55858918
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.40245921
34	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.38665018
35	Decreased central vision (HP:0007663)	2.33618896
36	Congenital hepatic fibrosis (HP:0002612)	2.32810476
37	Congenital primary aphakia (HP:0007707)	2.29751054
38	Gait imbalance (HP:0002141)	2.26848606
39	Optic nerve hypoplasia (HP:0000609)	2.22949024
40	Nephrogenic diabetes insipidus (HP:0009806)	2.22106111
41	Tubular atrophy (HP:0000092)	2.19500750
42	Erythroderma (HP:0001019)	2.17952154
43	Retinal dysplasia (HP:0007973)	2.16366249
44	Acute necrotizing encephalopathy (HP:0006965)	2.12967889
45	Pallor (HP:0000980)	2.09629784
46	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.07789155
47	Poor coordination (HP:0002370)	2.06532053
48	Abnormality of the renal cortex (HP:0011035)	2.06039546
49	Increased IgM level (HP:0003496)	2.04304584
50	Retinitis pigmentosa (HP:0000510)	2.04135961
51	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.03126191
52	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.99525789
53	Macrocytic anemia (HP:0001972)	1.97437657
54	Hyperglycinemia (HP:0002154)	1.96036913
55	Asplenia (HP:0001746)	1.95634795
56	Abnormal rod and cone electroretinograms (HP:0008323)	1.95143054
57	Postaxial foot polydactyly (HP:0001830)	1.94550897
58	Abnormality of incisor morphology (HP:0011063)	1.93711099
59	Acute encephalopathy (HP:0006846)	1.93299545
60	Thyroid-stimulating hormone excess (HP:0002925)	1.88691261
61	Abnormal mitochondria in muscle tissue (HP:0008316)	1.87280520
62	Hypoplastic iliac wings (HP:0002866)	1.85536938
63	Septo-optic dysplasia (HP:0100842)	1.85304717
64	Depressed nasal ridge (HP:0000457)	1.84391111
65	Congenital stationary night blindness (HP:0007642)	1.84070369
66	Holoprosencephaly (HP:0001360)	1.84011240
67	Agitation (HP:0000713)	1.83621886
68	Growth hormone deficiency (HP:0000824)	1.82379976
69	Neoplasm of the adrenal cortex (HP:0100641)	1.82258213
70	Small hand (HP:0200055)	1.81571979
71	Short foot (HP:0001773)	1.79350135
72	Abnormality of macular pigmentation (HP:0008002)	1.78445369
73	Potter facies (HP:0002009)	1.76717421
74	Facial shape deformation (HP:0011334)	1.76717421
75	Abnormal drinking behavior (HP:0030082)	1.75877844
76	Polydipsia (HP:0001959)	1.75877844
77	Lissencephaly (HP:0001339)	1.75751320
78	Vaginal atresia (HP:0000148)	1.73078871
79	Diastasis recti (HP:0001540)	1.72436693
80	Hyperglycinuria (HP:0003108)	1.71970318
81	Decreased circulating renin level (HP:0003351)	1.71113039
82	Dandy-Walker malformation (HP:0001305)	1.70651098
83	Polyuria (HP:0000103)	1.68942187
84	Optic disc pallor (HP:0000543)	1.68250481
85	Genetic anticipation (HP:0003743)	1.67263842
86	Synostosis of carpal bones (HP:0005048)	1.67251715
87	Polyphagia (HP:0002591)	1.67236081
88	Severe Myopia (HP:0011003)	1.67114453
89	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.65992712
90	Ectopic kidney (HP:0000086)	1.65803431
91	Abdominal situs inversus (HP:0003363)	1.65349639
92	Abnormality of abdominal situs (HP:0011620)	1.65349639
93	Mitochondrial inheritance (HP:0001427)	1.64888331
94	Type I transferrin isoform profile (HP:0003642)	1.64886176
95	Hypokalemia (HP:0002900)	1.64304779
96	Genital tract atresia (HP:0001827)	1.64303931
97	Abnormal ciliary motility (HP:0012262)	1.63723997
98	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.63534657
99	Absence seizures (HP:0002121)	1.62834131
100	Oligodactyly (hands) (HP:0001180)	1.62787671

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	7.04698213
2	STK38L	5.73612861
3	STK16	5.25099841
4	LATS2	4.09241999
5	FRK	3.23640648
6	ZAK	2.41499100
7	PRKD3	2.19483195
8	WNK4	1.92148699
9	BMPR1B	1.91668871
10	STK3	1.85981601
11	NEK1	1.83528390
12	ADRBK2	1.65071849
13	MAP2K2	1.64974462
14	NLK	1.54868934
15	EPHA4	1.52081235
16	PIK3CA	1.51629398
17	NME1	1.46666358
18	ACVR1B	1.42257427
19	NEK2	1.33074439
20	NTRK2	1.27427974
21	STK38	1.25643576
22	TRIM28	1.22460213
23	MELK	1.20855443
24	DYRK2	1.19134898
25	PINK1	1.16412238
26	BCKDK	1.15816416
27	EPHB2	1.15196613
28	DAPK2	1.13015201
29	NUAK1	1.09989399
30	TIE1	1.08455713
31	WNK3	1.05152466
32	TYRO3	1.04085001
33	STK11	1.00073231
34	MAP2K7	0.96371135
35	CASK	0.94821683
36	STK39	0.91844030
37	TGFBR1	0.91623431
38	MAP3K4	0.91342291
39	TAF1	0.84563087
40	PAK3	0.84018283
41	GRK1	0.81255751
42	TAOK3	0.74724426
43	CAMK1	0.74064156
44	CSNK1A1L	0.73981897
45	ADRBK1	0.73197841
46	PRKAA2	0.73002799
47	NTRK3	0.66546625
48	BCR	0.65614344
49	MAPK13	0.63555435
50	PRKCG	0.63319892
51	MKNK2	0.63201810
52	PLK1	0.58067100
53	GRK5	0.57250429
54	AURKB	0.56442446
55	GRK7	0.55444624
56	PIK3CG	0.53986045
57	MAPK15	0.53011298
58	CDK19	0.50992529
59	DYRK1B	0.49476501
60	LIMK1	0.47691920
61	PRKACA	0.43810765
62	DAPK3	0.43149580
63	PRKCE	0.42452804
64	CSNK1G2	0.40400248
65	PKN1	0.38728453
66	PLK3	0.38536693
67	FGFR1	0.38307935
68	ERBB2	0.38226522
69	PIM1	0.36057740
70	PRKCH	0.35763733
71	INSRR	0.34677913
72	PLK2	0.33730371
73	PRKCI	0.33656171
74	PRKACB	0.33006161
75	PRKCZ	0.31974647
76	MAP3K7	0.31099457
77	CAMK2A	0.30948791
78	VRK1	0.30203763
79	PRKCQ	0.30108660
80	CSNK2A2	0.29491992
81	CAMK4	0.28647064
82	DYRK1A	0.28094049
83	RPS6KA6	0.26660739
84	ATR	0.26589809
85	PRKD1	0.26034660
86	SGK1	0.25081082
87	OXSR1	0.24179079
88	CSNK1A1	0.23670330
89	PDPK1	0.23664922
90	MARK2	0.22614139
91	CHEK2	0.22287537
92	CAMK1D	0.22035569
93	BRAF	0.20281396
94	CSNK1D	0.19987878
95	MAP2K4	0.19157745
96	MARK1	0.18186479
97	PRKCA	0.17892052
98	OBSCN	0.17312884
99	DMPK	0.17088305
100	EIF2AK3	0.17081437

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.96324003
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.69209340
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.67314884
4	Sulfur relay system_Homo sapiens_hsa04122	3.48458090
5	Phototransduction_Homo sapiens_hsa04744	3.04354714
6	Nicotine addiction_Homo sapiens_hsa05033	3.03102911
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.24600150
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.24054029
9	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.22604540
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.18178661
11	Butanoate metabolism_Homo sapiens_hsa00650	1.98303028
12	One carbon pool by folate_Homo sapiens_hsa00670	1.97686294
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.92661924
14	Parkinsons disease_Homo sapiens_hsa05012	1.68694291
15	Basal transcription factors_Homo sapiens_hsa03022	1.64556505
16	RNA polymerase_Homo sapiens_hsa03020	1.64003392
17	Morphine addiction_Homo sapiens_hsa05032	1.62868090
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.62101389
19	Protein export_Homo sapiens_hsa03060	1.57564321
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.54755720
21	Asthma_Homo sapiens_hsa05310	1.54556271
22	Taste transduction_Homo sapiens_hsa04742	1.53261613
23	Caffeine metabolism_Homo sapiens_hsa00232	1.51802388
24	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.49121610
25	Basal cell carcinoma_Homo sapiens_hsa05217	1.48478430
26	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.45823814
27	GABAergic synapse_Homo sapiens_hsa04727	1.43360142
28	RNA degradation_Homo sapiens_hsa03018	1.38605342
29	Huntingtons disease_Homo sapiens_hsa05016	1.38369324
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.37596549
31	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.36531451
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.32131126
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.32056692
34	Cardiac muscle contraction_Homo sapiens_hsa04260	1.29682030
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.29206417
36	Sphingolipid metabolism_Homo sapiens_hsa00600	1.19610891
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.14184751
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.08096723
39	Collecting duct acid secretion_Homo sapiens_hsa04966	1.04848435
40	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.04455960
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.01090102
42	Alzheimers disease_Homo sapiens_hsa05010	0.97051916
43	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.95860667
44	Homologous recombination_Homo sapiens_hsa03440	0.95537527
45	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.94996011
46	Glutamatergic synapse_Homo sapiens_hsa04724	0.91731344
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86355611
48	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.82394587
49	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.81103465
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.80583880
51	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.78143538
52	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.77226006
53	Serotonergic synapse_Homo sapiens_hsa04726	0.76284186
54	Hippo signaling pathway_Homo sapiens_hsa04390	0.73274639
55	Calcium signaling pathway_Homo sapiens_hsa04020	0.71467613
56	Glycerolipid metabolism_Homo sapiens_hsa00561	0.71332294
57	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.70420270
58	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.67243295
59	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.66161547
60	Non-homologous end-joining_Homo sapiens_hsa03450	0.66029208
61	Peroxisome_Homo sapiens_hsa04146	0.64982677
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63352854
63	Phenylalanine metabolism_Homo sapiens_hsa00360	0.62069470
64	Pyrimidine metabolism_Homo sapiens_hsa00240	0.60508432
65	Retinol metabolism_Homo sapiens_hsa00830	0.60174388
66	Mismatch repair_Homo sapiens_hsa03430	0.59208774
67	Propanoate metabolism_Homo sapiens_hsa00640	0.58969124
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.56534856
69	Folate biosynthesis_Homo sapiens_hsa00790	0.55640111
70	Metabolic pathways_Homo sapiens_hsa01100	0.54971032
71	Melanogenesis_Homo sapiens_hsa04916	0.54871457
72	Fatty acid degradation_Homo sapiens_hsa00071	0.54762906
73	Proteasome_Homo sapiens_hsa03050	0.53089152
74	Wnt signaling pathway_Homo sapiens_hsa04310	0.51682054
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48677212
76	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.48484712
77	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.47087343
78	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.46959624
79	Viral myocarditis_Homo sapiens_hsa05416	0.46296162
80	Tyrosine metabolism_Homo sapiens_hsa00350	0.46232570
81	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.45902882
82	Insulin secretion_Homo sapiens_hsa04911	0.45596035
83	Olfactory transduction_Homo sapiens_hsa04740	0.45020583
84	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.44821902
85	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.43562989
86	Allograft rejection_Homo sapiens_hsa05330	0.43242125
87	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.42614860
88	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.41972522
89	cAMP signaling pathway_Homo sapiens_hsa04024	0.41507614
90	Ether lipid metabolism_Homo sapiens_hsa00565	0.40378174
91	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.40135048
92	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.38541872
93	Purine metabolism_Homo sapiens_hsa00230	0.38493293
94	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.37654969
95	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.37312335
96	Bile secretion_Homo sapiens_hsa04976	0.36158479
97	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.35094419
98	Nucleotide excision repair_Homo sapiens_hsa03420	0.34288664
99	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33996354
100	Circadian entrainment_Homo sapiens_hsa04713	0.32656151

RPS23P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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