RPS23P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of skeletal muscle tissue development (GO:0048642)9.66938832
2regulation of skeletal muscle contraction (GO:0014819)9.59336050
3response to muscle activity (GO:0014850)9.31133135
4actin-mediated cell contraction (GO:0070252)8.37249261
5cellular response to dexamethasone stimulus (GO:0071549)7.24076687
6response to dexamethasone (GO:0071548)6.70040345
7response to activity (GO:0014823)6.46021445
8actin filament-based movement (GO:0030048)5.87728585
9striated muscle adaptation (GO:0014888)5.81375495
10protein K6-linked ubiquitination (GO:0085020)5.68294501
11ribosomal small subunit biogenesis (GO:0042274)5.44137805
12viral transcription (GO:0019083)5.15213159
13negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.99155662
14translational termination (GO:0006415)4.88909199
15maturation of SSU-rRNA (GO:0030490)4.78013738
16muscle adaptation (GO:0043500)4.77856488
17regulation of muscle hypertrophy (GO:0014743)4.69500706
18dosage compensation (GO:0007549)4.63395165
19negative regulation of fatty acid biosynthetic process (GO:0045717)4.60518446
20protein trimerization (GO:0070206)4.53070126
21translational elongation (GO:0006414)4.49560609
22negative regulation of organelle assembly (GO:1902116)4.42447902
23response to testosterone (GO:0033574)4.31193027
24skeletal muscle contraction (GO:0003009)4.25392154
25response to electrical stimulus (GO:0051602)4.14022565
26negative regulation of striated muscle tissue development (GO:0045843)4.07990337
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.05957067
28muscle organ development (GO:0007517)4.05687040
29ribosomal small subunit assembly (GO:0000028)4.04907777
30positive regulation of histone H3-K4 methylation (GO:0051571)4.02700454
31regulation of DNA methylation (GO:0044030)4.00027981
32tissue regeneration (GO:0042246)3.98333099
33protein targeting to ER (GO:0045047)3.98145269
34cotranslational protein targeting to membrane (GO:0006613)3.96932031
35muscle structure development (GO:0061061)3.96709353
36negative regulation of muscle tissue development (GO:1901862)3.94137251
37establishment of protein localization to endoplasmic reticulum (GO:0072599)3.83669921
38DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.80778628
39negative regulation of muscle organ development (GO:0048635)3.78411994
40myotube cell development (GO:0014904)3.77085319
41positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.75833027
42negative regulation of histone acetylation (GO:0035067)3.72942107
43protein localization to endoplasmic reticulum (GO:0070972)3.70509060
44cellular protein complex disassembly (GO:0043624)3.69337855
45regulation of centriole replication (GO:0046599)3.68896798
46cellular response to glucocorticoid stimulus (GO:0071385)3.68880410
47nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.66690578
48embryonic skeletal joint morphogenesis (GO:0060272)3.62824590
49viral life cycle (GO:0019058)3.60395915
50translational initiation (GO:0006413)3.56579495
51DNA damage response, signal transduction resulting in transcription (GO:0042772)3.49298988
52cellular response to corticosteroid stimulus (GO:0071384)3.43986586
53negative regulation of peptidyl-lysine acetylation (GO:2000757)3.43781896
54regulation of relaxation of muscle (GO:1901077)3.39689245
55cullin deneddylation (GO:0010388)3.39139128
56cellular response to ketone (GO:1901655)3.37159962
57regulation of gene expression by genetic imprinting (GO:0006349)3.35319925
58muscle system process (GO:0003012)3.24069848
59viral genome replication (GO:0019079)3.23162963
60heparin metabolic process (GO:0030202)3.17511489
61heparin biosynthetic process (GO:0030210)3.17511489
62negative regulation of fatty acid metabolic process (GO:0045922)3.17508977
63protein complex disassembly (GO:0043241)3.16399557
64response to inactivity (GO:0014854)3.12454115
65negative regulation of protein acetylation (GO:1901984)3.12377547
66skeletal muscle fiber development (GO:0048741)3.11498280
67muscle contraction (GO:0006936)3.08795311
68translation (GO:0006412)3.08076183
69response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.06636172
70regulation of histone H3-K9 methylation (GO:0051570)3.02197497
71chaperone-mediated protein transport (GO:0072321)3.00424102
72pattern specification involved in kidney development (GO:0061004)2.96368402
73macromolecular complex disassembly (GO:0032984)2.95104245
74protein deneddylation (GO:0000338)2.93723726
75heart field specification (GO:0003128)2.91339354
76secondary heart field specification (GO:0003139)2.91339354
77middle ear morphogenesis (GO:0042474)2.90878769
78sarcoplasmic reticulum calcium ion transport (GO:0070296)2.88589751
79genetic imprinting (GO:0071514)2.85705486
80mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.80136648
81rRNA processing (GO:0006364)2.78189479
82energy coupled proton transport, down electrochemical gradient (GO:0015985)2.73081374
83ATP synthesis coupled proton transport (GO:0015986)2.73081374
84ribonucleoprotein complex biogenesis (GO:0022613)2.71766854
85protein neddylation (GO:0045116)2.68708992
86muscle cell cellular homeostasis (GO:0046716)2.67983940
87protein targeting to membrane (GO:0006612)2.65961899
88outer ear morphogenesis (GO:0042473)2.63776212
89rRNA metabolic process (GO:0016072)2.63124251
90postreplication repair (GO:0006301)2.62988039
91prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.62742706
92negative regulation of histone methylation (GO:0031061)2.60757156
93response to gravity (GO:0009629)15.1563391
94skeletal muscle adaptation (GO:0043501)13.5264518
95striated muscle atrophy (GO:0014891)13.2603792
96muscle atrophy (GO:0014889)12.1302448
97negative regulation of muscle hypertrophy (GO:0014741)11.2399072
98skeletal muscle tissue regeneration (GO:0043403)10.6573919
99actin-myosin filament sliding (GO:0033275)10.2188010
100muscle filament sliding (GO:0030049)10.2188010

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human8.55854303
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat7.98651153
3CHD7_19251738_ChIP-ChIP_MESCs_Mouse6.34666493
4RBPJ_22232070_ChIP-Seq_NCS_Mouse6.01330502
5BP1_19119308_ChIP-ChIP_Hs578T_Human5.41080977
6TAF15_26573619_Chip-Seq_HEK293_Human4.04061981
7EZH2_22144423_ChIP-Seq_EOC_Human3.94531974
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.15711334
9FUS_26573619_Chip-Seq_HEK293_Human3.06081164
10AR_21572438_ChIP-Seq_LNCaP_Human2.82047711
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.48621502
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.26506003
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.17950897
14POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.17855533
15ERG_21242973_ChIP-ChIP_JURKAT_Human2.06246194
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.04548271
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.97506018
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.96682629
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.86127171
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.84915318
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73531544
22GABP_17652178_ChIP-ChIP_JURKAT_Human1.73024953
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.66270076
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61085999
25TP53_20018659_ChIP-ChIP_R1E_Mouse1.55494211
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55400494
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54185816
28TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.48961220
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42170709
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.39574579
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36685197
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36041075
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33291394
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.31004457
35TTF2_22483619_ChIP-Seq_HELA_Human1.30226901
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29081769
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29081769
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29081769
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.27078162
40TP53_22573176_ChIP-Seq_HFKS_Human1.25522674
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22716779
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.19837870
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19429512
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.14074965
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.14063222
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.13659143
47MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.12119219
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11952490
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11700714
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11700714
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11185130
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10901377
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09655689
54DCP1A_22483619_ChIP-Seq_HELA_Human1.08944895
55XRN2_22483619_ChIP-Seq_HELA_Human1.07014809
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06434703
57ER_23166858_ChIP-Seq_MCF-7_Human1.05568062
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00686761
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98762012
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97515357
61CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97351323
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95619690
63ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94659906
64SOX9_26525672_Chip-Seq_HEART_Mouse0.93894966
65PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91881886
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90251760
67VDR_23849224_ChIP-Seq_CD4+_Human0.90235112
68RXR_22108803_ChIP-Seq_LS180_Human0.89256781
69KDM2B_26808549_Chip-Seq_REH_Human0.87076272
70THAP11_20581084_ChIP-Seq_MESCs_Mouse0.84743856
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.83630848
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.81967669
73CTBP1_25329375_ChIP-Seq_LNCAP_Human0.81457421
74SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.81314280
75EZH2_27294783_Chip-Seq_ESCs_Mouse0.79912459
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.78960582
77SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78729097
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78369480
79SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.78060175
80TAL1_26923725_Chip-Seq_HPCs_Mouse0.77082971
81CEBPB_22108803_ChIP-Seq_LS180_Human0.76969357
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.73860035
83MYC_18358816_ChIP-ChIP_MESCs_Mouse0.73154746
84ELF1_17652178_ChIP-ChIP_JURKAT_Human0.72496522
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72251084
86SUZ12_27294783_Chip-Seq_ESCs_Mouse0.72176206
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.69568611
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.67645451
89RING1B_27294783_Chip-Seq_ESCs_Mouse0.67645163
90FOXP3_21729870_ChIP-Seq_TREG_Human0.67257665
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.66317951
92P53_22127205_ChIP-Seq_FIBROBLAST_Human0.65793555
93RARG_19884340_ChIP-ChIP_MEFs_Mouse0.65032375
94EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.64035333
95TDRD3_21172665_ChIP-Seq_MCF-7_Human0.63810761
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.62152208
97MYC_19829295_ChIP-Seq_ESCs_Human0.61904561
98TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.61895323
99SRF_21415370_ChIP-Seq_HL-1_Mouse0.61396742
100NFIB_24661679_ChIP-Seq_LUNG_Mouse0.61037653

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000747_muscle_weakness5.97122903
2MP0004145_abnormal_muscle_electrophysio5.82027516
3MP0003705_abnormal_hypodermis_morpholog4.87637039
4MP0002089_abnormal_postnatal_growth/wei4.79778286
5MP0000749_muscle_degeneration4.26519648
6MP0004036_abnormal_muscle_relaxation4.25280297
7MP0002269_muscular_atrophy4.17474126
8MP0000759_abnormal_skeletal_muscle3.66344078
9MP0005083_abnormal_biliary_tract3.21891099
10MP0002108_abnormal_muscle_morphology3.05307856
11MP0004087_abnormal_muscle_fiber2.91131461
12MP0002106_abnormal_muscle_physiology2.84130850
13MP0005620_abnormal_muscle_contractility2.66508994
14MP0000566_synostosis2.64317861
15MP0000750_abnormal_muscle_regeneration2.31083068
16MP0005369_muscle_phenotype2.27030164
17MP0000733_abnormal_muscle_development2.21369209
18MP0003959_abnormal_lean_body2.09131625
19MP0000751_myopathy2.06675339
20MP0002638_abnormal_pupillary_reflex1.92700476
21MP0003123_paternal_imprinting1.91212616
22MP0009250_abnormal_appendicular_skeleto1.77100251
23MP0003937_abnormal_limbs/digits/tail_de1.73868874
24MP0002896_abnormal_bone_mineralization1.64470249
25MP0008057_abnormal_DNA_replication1.55510429
26MP0004270_analgesia1.55416011
27MP0000049_abnormal_middle_ear1.54694674
28MP0003646_muscle_fatigue1.52139985
29MP0000372_irregular_coat_pigmentation1.51161166
30MP0002277_abnormal_respiratory_mucosa1.47040168
31MP0002095_abnormal_skin_pigmentation1.44864056
32MP0010307_abnormal_tumor_latency1.40014644
33MP0009780_abnormal_chondrocyte_physiolo1.34391703
34MP0002736_abnormal_nociception_after1.32319007
35MP0010030_abnormal_orbit_morphology1.26685205
36MP0003045_fibrosis1.23857092
37MP0003786_premature_aging1.23083341
38MP0009379_abnormal_foot_pigmentation1.13960584
39MP0000427_abnormal_hair_cycle1.13228563
40MP0003950_abnormal_plasma_membrane1.08849271
41MP0000537_abnormal_urethra_morphology1.03738163
42MP0001968_abnormal_touch/_nociception1.02074846
43MP0002114_abnormal_axial_skeleton0.97953384
44MP0002177_abnormal_outer_ear0.97040751
45MP0003938_abnormal_ear_development0.96491308
46MP0001879_abnormal_lymphatic_vessel0.95712407
47MP0004142_abnormal_muscle_tone0.94189247
48MP0003385_abnormal_body_wall0.93771291
49MP0000678_abnormal_parathyroid_gland0.92300706
50MP0001243_abnormal_dermal_layer0.87731096
51MP0004084_abnormal_cardiac_muscle0.86355894
52MP0002109_abnormal_limb_morphology0.84263305
53MP0002115_abnormal_skeleton_extremities0.82685233
54MP0002138_abnormal_hepatobiliary_system0.82105880
55MP0000631_abnormal_neuroendocrine_gland0.81302455
56MP0004130_abnormal_muscle_cell0.81070697
57MP0003755_abnormal_palate_morphology0.79220800
58MP0004484_altered_response_of0.77777258
59MP0000467_abnormal_esophagus_morphology0.75446244
60MP0002127_abnormal_cardiovascular_syste0.74791167
61MP0004215_abnormal_myocardial_fiber0.74063837
62MP0008438_abnormal_cutaneous_collagen0.73806833
63MP0003880_abnormal_central_pattern0.71737431
64MP0002876_abnormal_thyroid_physiology0.71304424
65MP0003315_abnormal_perineum_morphology0.68400439
66MP0002160_abnormal_reproductive_system0.65537054
67MP0005423_abnormal_somatic_nervous0.64428364
68MP0003936_abnormal_reproductive_system0.61827740
69MP0002837_dystrophic_cardiac_calcinosis0.60705159
70MP0004134_abnormal_chest_morphology0.59309974
71MP0002116_abnormal_craniofacial_bone0.58999487
72MP0003942_abnormal_urinary_system0.58329056
73MP0005452_abnormal_adipose_tissue0.57153110
74MP0000627_abnormal_mammary_gland0.56334807
75MP0003806_abnormal_nucleotide_metabolis0.54149006
76MP0001340_abnormal_eyelid_morphology0.53046167
77MP0004885_abnormal_endolymph0.49848912
78MP0000163_abnormal_cartilage_morphology0.49280471
79MP0000534_abnormal_ureter_morphology0.49217987
80MP0003567_abnormal_fetal_cardiomyocyte0.49104779
81MP0000428_abnormal_craniofacial_morphol0.48453484
82MP0001905_abnormal_dopamine_level0.48267250
83MP0001299_abnormal_eye_distance/0.47841308
84MP0001661_extended_life_span0.47311854
85MP0003119_abnormal_digestive_system0.47139875
86MP0000778_abnormal_nervous_system0.46549893
87MP0000377_abnormal_hair_follicle0.46359832
88MP0001943_abnormal_respiration0.45913330
89MP0000266_abnormal_heart_morphology0.45750001
90MP0004043_abnormal_pH_regulation0.45285441
91MP0005645_abnormal_hypothalamus_physiol0.45142134
92MP0002184_abnormal_innervation0.44568438
93MP0002932_abnormal_joint_morphology0.41779148
94MP0002332_abnormal_exercise_endurance0.41587009
95MP0005334_abnormal_fat_pad0.41489347
96MP0001485_abnormal_pinna_reflex0.41395243
97MP0000470_abnormal_stomach_morphology0.40459171
98MP0005275_abnormal_skin_tensile0.39980309
99MP0008770_decreased_survivor_rate0.39642298
100MP0001502_abnormal_circadian_rhythm0.39615856

Predicted human phenotypes

RankGene SetZ-score
1Palpebral edema (HP:0100540)9.31743004
2Distal arthrogryposis (HP:0005684)7.53000140
3Nemaline bodies (HP:0003798)7.09858295
4Exercise-induced myalgia (HP:0003738)7.05294686
5Mask-like facies (HP:0000298)6.98450935
6Round ear (HP:0100830)6.86779498
7Absent phalangeal crease (HP:0006109)6.51312208
8Ulnar deviation of the wrist (HP:0003049)6.38066943
9Calcaneovalgus deformity (HP:0001848)5.99686691
10Deformed tarsal bones (HP:0008119)5.89121560
11Muscle fiber inclusion bodies (HP:0100299)5.72651287
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.63052025
13Abnormal finger flexion creases (HP:0006143)5.54599654
14Hyperkalemia (HP:0002153)5.33840939
15Type 1 muscle fiber predominance (HP:0003803)4.84388465
16Periorbital edema (HP:0100539)4.48005955
17Facial edema (HP:0000282)4.32903174
18Myopathic facies (HP:0002058)4.04293429
19Exercise-induced muscle cramps (HP:0003710)3.76787735
20Myotonia (HP:0002486)3.67624999
21Down-sloping shoulders (HP:0200021)3.59205851
22Myoglobinuria (HP:0002913)3.55056387
23Increased connective tissue (HP:0009025)3.41134406
24Abnormality of the calcaneus (HP:0008364)3.09858993
25Abnormality of potassium homeostasis (HP:0011042)2.99822501
26Fibular aplasia (HP:0002990)2.99023602
27Microglossia (HP:0000171)2.85956151
28Abnormality of the parietal bone (HP:0002696)2.84086399
29Rectal prolapse (HP:0002035)2.76368773
30Difficulty running (HP:0009046)2.74430967
31Metatarsus adductus (HP:0001840)2.69541192
32Hyperphosphatemia (HP:0002905)2.62105524
33Rhabdomyolysis (HP:0003201)2.60565763
34Supernumerary bones of the axial skeleton (HP:0009144)2.59474250
35Neoplasm of the heart (HP:0100544)2.59281446
36Reduced subcutaneous adipose tissue (HP:0003758)2.58994849
373-Methylglutaconic aciduria (HP:0003535)2.56361201
38Stenosis of the external auditory canal (HP:0000402)2.52771066
39Decreased circulating renin level (HP:0003351)2.52424652
40Muscle stiffness (HP:0003552)2.50822697
41Lip pit (HP:0100267)2.50109155
42Nonprogressive disorder (HP:0003680)2.49424021
43Mesomelia (HP:0003027)2.43629179
44Symphalangism affecting the phalanges of the hand (HP:0009773)2.43322849
45Supernumerary ribs (HP:0005815)2.42160472
46Hyperuricemia (HP:0002149)2.36891545
47Increased purine levels (HP:0004368)2.36891545
48Bell-shaped thorax (HP:0001591)2.36507574
49Acute necrotizing encephalopathy (HP:0006965)2.31396894
50Reticulocytopenia (HP:0001896)2.12388335
51Oligomenorrhea (HP:0000876)2.09531578
52Gout (HP:0001997)1.99582157
53Progressive macrocephaly (HP:0004481)1.99416891
54Abnormality of the peritoneum (HP:0002585)1.98521014
55Abnormality of the phalanges of the 2nd finger (HP:0009541)1.98289558
56Abnormal mitochondria in muscle tissue (HP:0008316)1.98073476
57Abnormality of the 4th metacarpal (HP:0010012)1.97882116
58Abnormality of cells of the erythroid lineage (HP:0012130)1.88984208
59Hypoplasia of the radius (HP:0002984)1.88829862
60Tarsal synostosis (HP:0008368)1.88088031
61Malignant hyperthermia (HP:0002047)1.82393035
62Synostosis involving bones of the lower limbs (HP:0009138)1.81274898
63Synostosis involving bones of the feet (HP:0009140)1.81274898
64Hypoplastic ischia (HP:0003175)1.81079958
65Hypokalemia (HP:0002900)1.79370708
66Paralysis (HP:0003470)1.77125874
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.76974448
68Short 4th metacarpal (HP:0010044)1.76974448
69Ulnar deviation of finger (HP:0009465)1.75571295
70Short phalanx of the thumb (HP:0009660)1.74490574
71Maternal diabetes (HP:0009800)1.72837657
72Abnormality of chloride homeostasis (HP:0011422)1.72787591
73Abnormality of the 2nd finger (HP:0004100)1.70498304
742-3 toe syndactyly (HP:0004691)1.69761239
75Increased variability in muscle fiber diameter (HP:0003557)1.68448021
76Toxemia of pregnancy (HP:0100603)1.67286278
77Hypoplastic iliac wings (HP:0002866)1.65442648
78Abnormality of the columella (HP:0009929)1.63568983
79Acute encephalopathy (HP:0006846)1.63073051
80Delayed CNS myelination (HP:0002188)1.63066852
81Macrocytic anemia (HP:0001972)1.61330285
82Muscle hypertrophy of the lower extremities (HP:0008968)1.61247610
83Skin pits (HP:0100276)1.59590394
84Abnormality of the ischium (HP:0003174)1.57531867
85Congenital hip dislocation (HP:0001374)1.55918633
86Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.55797407
87Metabolic acidosis (HP:0001942)1.52706423
88Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.50582269
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.49013621
90Abnormality of alanine metabolism (HP:0010916)1.49013621
91Hyperalaninemia (HP:0003348)1.49013621
92Abnormality of purine metabolism (HP:0004352)1.47006853
93Mitochondrial inheritance (HP:0001427)1.46573011
94Hypoalphalipoproteinemia (HP:0003233)1.45372483
95Intellectual disability, moderate (HP:0002342)1.44773029
96Macroorchidism (HP:0000053)1.42157124
97Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.41500054
98Abnormal drinking behavior (HP:0030082)1.40741432
99Polydipsia (HP:0001959)1.40741432
100Abnormality of the phalanges of the 5th finger (HP:0004213)1.39466715

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG25.28316250
2PHKG15.28316250
3TIE14.70014310
4OBSCN4.59006098
5NME23.79429852
6WNK43.72520328
7WNK13.08398255
8CAMK1D2.91361774
9TYRO32.30268361
10PIK3CA2.21865554
11CAMK1G2.17669045
12CAMKK22.03869242
13TXK1.93633650
14IRAK11.90815689
15SCYL21.77282154
16PDK21.68735470
17ARAF1.63149523
18LIMK11.57522393
19CCNB11.52809717
20CDK41.48392766
21TLK11.48004355
22JAK31.45363857
23CHEK21.42917381
24PIK3CG1.38405565
25DMPK1.37767266
26MAPK131.36188160
27STK161.35971348
28CAMK2G1.32005993
29AURKA1.29100953
30MST41.24950379
31MAP3K121.20005304
32STK391.17889979
33CASK1.17750549
34SRPK11.16701118
35EPHB21.15742215
36ILK1.00032893
37DYRK1B0.98298860
38NUAK10.95376251
39BUB10.94820242
40MAPK70.92612726
41VRK20.84358165
42CAMK10.76379677
43MARK30.76284095
44MUSK0.74863244
45TESK10.68151155
46TAF10.66978323
47MOS0.66761639
48BCKDK0.66578769
49DYRK30.64540455
50CSNK1G10.64071425
51LRRK20.61197685
52PRKG10.60900630
53CSNK1A1L0.58111488
54CAMK40.57943195
55CAMKK10.57671681
56PRKD30.56906528
57SGK20.54323297
58TESK20.52851645
59CSNK1G20.51776646
60SGK10.50782527
61TEC0.50747965
62PIM10.45329259
63MAPK120.44294043
64CSNK1G30.44260290
65RPS6KA50.42171806
66PIM20.41679929
67SGK2230.41149794
68SGK4940.41149794
69DYRK20.41004044
70DDR20.40781537
71ABL20.39507955
72EIF2AK20.38981429
73RPS6KA40.35492632
74NEK10.34508510
75RPS6KL10.32725403
76RPS6KC10.32725403
77RPS6KA60.32398384
78BRAF0.31599298
79OXSR10.31177937
80MAP2K30.28982134
81CSNK2A10.28602050
82VRK10.28279097
83ADRBK20.27074868
84SGK30.26984618
85DAPK10.26683126
86PINK10.26231508
87PRKACA0.25120989
88PRKACB0.23545923
89PLK40.23483361
90MAP2K70.23306745
91ATR0.22865637
92MKNK20.22171815
93AKT20.19445714
94FGFR10.17883078
95RPS6KA30.17592121
96CSNK2A20.16631946
97NEK20.16093703
98PAK10.14368044
99TNIK0.11305591
100MAP3K110.10375409

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.44193156
2Tight junction_Homo sapiens_hsa045304.29975270
3Regulation of autophagy_Homo sapiens_hsa041403.53314500
4Oxidative phosphorylation_Homo sapiens_hsa001902.55282554
5Cardiac muscle contraction_Homo sapiens_hsa042602.35359101
6Parkinsons disease_Homo sapiens_hsa050122.12870195
7Alzheimers disease_Homo sapiens_hsa050102.10942123
8Proteasome_Homo sapiens_hsa030501.96453030
9Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.85761917
10Huntingtons disease_Homo sapiens_hsa050161.82868130
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.78262642
12Oxytocin signaling pathway_Homo sapiens_hsa049211.73251678
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60784736
14Nitrogen metabolism_Homo sapiens_hsa009101.58229124
15Spliceosome_Homo sapiens_hsa030401.57452304
16Calcium signaling pathway_Homo sapiens_hsa040201.54554795
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.52561215
18Wnt signaling pathway_Homo sapiens_hsa043101.49965384
19RNA degradation_Homo sapiens_hsa030181.49178215
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46944687
21Hedgehog signaling pathway_Homo sapiens_hsa043401.42556921
22cGMP-PKG signaling pathway_Homo sapiens_hsa040221.37656141
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29459872
24Gastric acid secretion_Homo sapiens_hsa049711.26702813
25RNA polymerase_Homo sapiens_hsa030201.24884097
26Glucagon signaling pathway_Homo sapiens_hsa049221.20861698
27Arginine biosynthesis_Homo sapiens_hsa002201.20607207
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.17215472
29Circadian entrainment_Homo sapiens_hsa047131.14957958
30Insulin secretion_Homo sapiens_hsa049111.09958794
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09843661
32Renin secretion_Homo sapiens_hsa049241.07852766
33Circadian rhythm_Homo sapiens_hsa047101.06946402
34Basal cell carcinoma_Homo sapiens_hsa052171.06368648
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.06268196
36Basal transcription factors_Homo sapiens_hsa030221.06200305
37Sulfur relay system_Homo sapiens_hsa041221.05303380
38Protein export_Homo sapiens_hsa030601.02274806
39Dilated cardiomyopathy_Homo sapiens_hsa054141.00918628
40Long-term potentiation_Homo sapiens_hsa047200.98090923
41Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91279930
42Morphine addiction_Homo sapiens_hsa050320.90276395
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89574634
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86521454
45Fanconi anemia pathway_Homo sapiens_hsa034600.84944424
46Adherens junction_Homo sapiens_hsa045200.83709332
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81884867
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81424712
49Dopaminergic synapse_Homo sapiens_hsa047280.80802670
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78796251
51Oocyte meiosis_Homo sapiens_hsa041140.77183663
52Cholinergic synapse_Homo sapiens_hsa047250.76634270
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75476526
54TGF-beta signaling pathway_Homo sapiens_hsa043500.69405057
55Amphetamine addiction_Homo sapiens_hsa050310.68099148
56Salivary secretion_Homo sapiens_hsa049700.67862466
57RNA transport_Homo sapiens_hsa030130.66441695
58Glutathione metabolism_Homo sapiens_hsa004800.65449815
59Pancreatic secretion_Homo sapiens_hsa049720.64929782
60Systemic lupus erythematosus_Homo sapiens_hsa053220.61782801
61HIF-1 signaling pathway_Homo sapiens_hsa040660.61290993
62Purine metabolism_Homo sapiens_hsa002300.60554382
63Pyrimidine metabolism_Homo sapiens_hsa002400.57987201
64Axon guidance_Homo sapiens_hsa043600.54154146
65Folate biosynthesis_Homo sapiens_hsa007900.53805672
66Epstein-Barr virus infection_Homo sapiens_hsa051690.52320634
67MAPK signaling pathway_Homo sapiens_hsa040100.51613711
68Long-term depression_Homo sapiens_hsa047300.51117278
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50648481
70Olfactory transduction_Homo sapiens_hsa047400.50353116
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49689416
72T cell receptor signaling pathway_Homo sapiens_hsa046600.49008066
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45128018
74mRNA surveillance pathway_Homo sapiens_hsa030150.44828364
75Viral carcinogenesis_Homo sapiens_hsa052030.44720744
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42359830
77Nucleotide excision repair_Homo sapiens_hsa034200.42232973
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41828171
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.41618257
80cAMP signaling pathway_Homo sapiens_hsa040240.41332312
81Chemical carcinogenesis_Homo sapiens_hsa052040.40467188
82DNA replication_Homo sapiens_hsa030300.36887852
83GABAergic synapse_Homo sapiens_hsa047270.36011252
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35311316
85Melanoma_Homo sapiens_hsa052180.31482612
86Nicotine addiction_Homo sapiens_hsa050330.31224378
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30176673
88Melanogenesis_Homo sapiens_hsa049160.30136116
89Alcoholism_Homo sapiens_hsa050340.29491600
90ErbB signaling pathway_Homo sapiens_hsa040120.28755734
91Measles_Homo sapiens_hsa051620.27871469
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27631562
93AMPK signaling pathway_Homo sapiens_hsa041520.27324958
94Notch signaling pathway_Homo sapiens_hsa043300.27235706
95Homologous recombination_Homo sapiens_hsa034400.26866965
96Asthma_Homo sapiens_hsa053100.26814956
97Serotonergic synapse_Homo sapiens_hsa047260.25461598
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.24109032
99Mineral absorption_Homo sapiens_hsa049780.23849599
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22188581

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