RPS23P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1translational termination (GO:0006415)9.84768176
2ribosomal small subunit biogenesis (GO:0042274)9.83471980
3SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.12031814
4ribosomal small subunit assembly (GO:0000028)8.10700169
5translational elongation (GO:0006414)8.00494147
6cotranslational protein targeting to membrane (GO:0006613)7.98753108
7protein targeting to ER (GO:0045047)7.93286581
8establishment of protein localization to endoplasmic reticulum (GO:0072599)7.60036040
9cellular protein complex disassembly (GO:0043624)7.59403147
10protein localization to endoplasmic reticulum (GO:0070972)7.45154648
11viral life cycle (GO:0019058)7.42061279
12nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.05919822
13protein complex disassembly (GO:0043241)6.35749769
14translational initiation (GO:0006413)6.18364957
15energy coupled proton transport, down electrochemical gradient (GO:0015985)6.02577089
16ATP synthesis coupled proton transport (GO:0015986)6.02577089
17maturation of SSU-rRNA (GO:0030490)5.93470905
18macromolecular complex disassembly (GO:0032984)5.92883381
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.74241738
20protein targeting to membrane (GO:0006612)5.29493790
21ribosomal large subunit biogenesis (GO:0042273)5.11914378
22nuclear-transcribed mRNA catabolic process (GO:0000956)4.86490930
23regulation of activation of Janus kinase activity (GO:0010533)4.74098876
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.61834099
25translation (GO:0006412)4.59272023
26mRNA catabolic process (GO:0006402)4.55049247
27mitochondrial respiratory chain complex I assembly (GO:0032981)4.20795484
28NADH dehydrogenase complex assembly (GO:0010257)4.20795484
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.20795484
30RNA catabolic process (GO:0006401)4.14584491
31ribonucleoprotein complex biogenesis (GO:0022613)4.13811969
32respiratory electron transport chain (GO:0022904)4.11175152
33electron transport chain (GO:0022900)4.05522493
34behavioral response to nicotine (GO:0035095)4.05498862
35protein complex biogenesis (GO:0070271)3.98971089
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.88905044
37cellular component biogenesis (GO:0044085)3.82792490
38epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.67972164
39establishment of protein localization to membrane (GO:0090150)3.57667591
40ATP biosynthetic process (GO:0006754)3.48102502
41mitochondrial respiratory chain complex assembly (GO:0033108)3.41023287
42protein targeting (GO:0006605)3.36761602
43purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.32851063
44chaperone-mediated protein transport (GO:0072321)3.25711087
45purine nucleoside triphosphate biosynthetic process (GO:0009145)3.24827330
46establishment of protein localization to organelle (GO:0072594)3.20173961
47cell proliferation in forebrain (GO:0021846)3.18695423
48maturation of 5.8S rRNA (GO:0000460)3.15795644
49intracellular protein transmembrane import (GO:0044743)3.07555632
50positive regulation of mast cell activation involved in immune response (GO:0033008)2.92612759
51positive regulation of mast cell degranulation (GO:0043306)2.92612759
52ribonucleoside triphosphate biosynthetic process (GO:0009201)2.89507821
53protein neddylation (GO:0045116)2.89499289
54protein localization to membrane (GO:0072657)2.86090539
55ncRNA 3-end processing (GO:0043628)2.85706513
56GTP biosynthetic process (GO:0006183)2.84554840
57protein-cofactor linkage (GO:0018065)2.83076783
58hydrogen ion transmembrane transport (GO:1902600)2.77675805
59positive regulation of mast cell activation (GO:0033005)2.77659659
60nucleotide transmembrane transport (GO:1901679)2.77389451
61pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.74093178
62short-term memory (GO:0007614)2.67276390
63cardiovascular system development (GO:0072358)2.64235076
64negative regulation of T cell differentiation in thymus (GO:0033085)2.62688983
65positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.60827472
66neuronal stem cell maintenance (GO:0097150)2.60463304
67regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.58811549
68neuron fate determination (GO:0048664)2.58475902
69pyrimidine nucleobase catabolic process (GO:0006208)2.57745164
70nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.54816368
71preassembly of GPI anchor in ER membrane (GO:0016254)2.54496088
72protein import into peroxisome matrix (GO:0016558)2.53817136
73exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.50461058
74rRNA processing (GO:0006364)2.48128537
75somite development (GO:0061053)2.47337820
76DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.46219169
77rRNA metabolic process (GO:0016072)2.45051806
78positive regulation of respiratory burst (GO:0060267)2.44153538
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.43756872
80proton transport (GO:0015992)2.43598984
81segment specification (GO:0007379)2.42939403
82kidney morphogenesis (GO:0060993)2.41972999
83tongue development (GO:0043586)2.38411340
84pattern specification involved in kidney development (GO:0061004)2.38388098
85regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.38044207
86otic vesicle formation (GO:0030916)2.37991707
87nonmotile primary cilium assembly (GO:0035058)2.37896422
88hydrogen transport (GO:0006818)2.37843960
89platelet dense granule organization (GO:0060155)2.36930719
90positive regulation of potassium ion transmembrane transport (GO:1901381)2.36561692
91nucleoside triphosphate biosynthetic process (GO:0009142)2.35146177
92histone H4-K12 acetylation (GO:0043983)2.34327412
93lens fiber cell development (GO:0070307)2.33513266
94UTP biosynthetic process (GO:0006228)2.32768931
95centriole replication (GO:0007099)2.32153962
96protein localization to organelle (GO:0033365)2.30601493
97skeletal muscle tissue regeneration (GO:0043403)2.29848744
98DNA damage response, signal transduction resulting in transcription (GO:0042772)2.28103827
99epithelial cilium movement (GO:0003351)2.26681202
100viral transcription (GO:0019083)10.2899623

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat7.01106180
2EZH2_22144423_ChIP-Seq_EOC_Human5.17687447
3VDR_22108803_ChIP-Seq_LS180_Human2.96856251
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.73597085
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.48539257
6CBX2_27304074_Chip-Seq_ESCs_Mouse2.44493219
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.44307334
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.31405333
9CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.28746318
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28568516
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.26435422
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.13638917
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12301468
14EZH2_27294783_Chip-Seq_ESCs_Mouse1.97995033
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97105792
16IRF1_19129219_ChIP-ChIP_H3396_Human1.90761274
17ETS1_20019798_ChIP-Seq_JURKAT_Human1.90760100
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87093001
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.85519349
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85282314
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83376559
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.82294780
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79444806
24CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.74390666
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69675767
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.68857743
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.64289669
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61814317
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.60238193
30RNF2_27304074_Chip-Seq_NSC_Mouse1.60232566
31TDRD3_21172665_ChIP-Seq_MCF-7_Human1.57686139
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56052908
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53499841
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.51104355
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.51019247
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48891245
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48891245
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48252012
39TP53_20018659_ChIP-ChIP_R1E_Mouse1.47595336
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46424439
41ZNF274_21170338_ChIP-Seq_K562_Hela1.46275209
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46257953
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44006027
44CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.40496848
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38298664
46TAF2_19829295_ChIP-Seq_ESCs_Human1.37949151
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.37654136
48TAF15_26573619_Chip-Seq_HEK293_Human1.35320086
49FUS_26573619_Chip-Seq_HEK293_Human1.26865625
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26468451
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25945362
52REST_21632747_ChIP-Seq_MESCs_Mouse1.23831564
53MYC_18940864_ChIP-ChIP_HL60_Human1.23711466
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22473387
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20294512
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19091405
57EWS_26573619_Chip-Seq_HEK293_Human1.18495879
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17080806
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17038359
60TTF2_22483619_ChIP-Seq_HELA_Human1.16965617
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16950028
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15351794
63ERA_21632823_ChIP-Seq_H3396_Human1.14564684
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.14281894
65AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13156517
66XRN2_22483619_ChIP-Seq_HELA_Human1.12405934
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11699642
68NANOG_20526341_ChIP-Seq_ESCs_Human1.10797832
69JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10191450
70ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10061322
71CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09269664
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.06939342
73P300_19829295_ChIP-Seq_ESCs_Human1.06021023
74NCOR_22424771_ChIP-Seq_293T_Human1.04243517
75VDR_23849224_ChIP-Seq_CD4+_Human1.03957442
76TP53_22573176_ChIP-Seq_HFKS_Human1.03809782
77CTCF_27219007_Chip-Seq_Bcells_Human1.03687209
78MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02903006
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.02030744
80FOXA1_25329375_ChIP-Seq_VCAP_Human1.00971962
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00971962
82CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00875843
83SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98116990
84AR_20517297_ChIP-Seq_VCAP_Human0.97823125
85FLI1_27457419_Chip-Seq_LIVER_Mouse0.97733606
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97351743
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97348134
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97131631
89HTT_18923047_ChIP-ChIP_STHdh_Human0.96346211
90ELK1_19687146_ChIP-ChIP_HELA_Human0.96008421
91SA1_27219007_Chip-Seq_Bcells_Human0.95866443
92E2F1_20622854_ChIP-Seq_HELA_Human0.95616233
93RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95358964
94BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.93993676
95BCL6_27268052_Chip-Seq_Bcells_Human0.93950491
96SOX2_16153702_ChIP-ChIP_HESCs_Human0.93586568
97MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93322089
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92987082
99EGR1_19032775_ChIP-ChIP_M12_Human0.91670557
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89841990

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.58866885
2MP0006292_abnormal_olfactory_placode4.93905980
3MP0000566_synostosis2.89564813
4MP0003136_yellow_coat_color2.88130980
5MP0008789_abnormal_olfactory_epithelium2.67041011
6MP0006082_CNS_inflammation2.64256825
7MP0003878_abnormal_ear_physiology2.50613573
8MP0005377_hearing/vestibular/ear_phenot2.50613573
9MP0003646_muscle_fatigue2.42442535
10MP0002837_dystrophic_cardiac_calcinosis2.30814365
11MP0004145_abnormal_muscle_electrophysio2.21785535
12MP0005394_taste/olfaction_phenotype2.06380379
13MP0005499_abnormal_olfactory_system2.06380379
14MP0002277_abnormal_respiratory_mucosa2.06203462
15MP0010030_abnormal_orbit_morphology1.83142528
16MP0000049_abnormal_middle_ear1.79120167
17MP0004142_abnormal_muscle_tone1.76598536
18MP0003122_maternal_imprinting1.75547923
19MP0000631_abnormal_neuroendocrine_gland1.75023567
20MP0003121_genomic_imprinting1.74686408
21MP0001293_anophthalmia1.72129892
22MP0001873_stomach_inflammation1.67672534
23MP0002938_white_spotting1.67483820
24MP0002095_abnormal_skin_pigmentation1.65361960
25MP0003879_abnormal_hair_cell1.63654041
26MP0003787_abnormal_imprinting1.52982106
27MP0004885_abnormal_endolymph1.51607265
28MP0002876_abnormal_thyroid_physiology1.45825349
29MP0002132_abnormal_respiratory_system1.45449328
30MP0002163_abnormal_gland_morphology1.44560178
31MP0002638_abnormal_pupillary_reflex1.43915741
32MP0001348_abnormal_lacrimal_gland1.37749173
33MP0005423_abnormal_somatic_nervous1.34123766
34MP0006072_abnormal_retinal_apoptosis1.31364794
35MP0003938_abnormal_ear_development1.31152811
36MP0008875_abnormal_xenobiotic_pharmacok1.29962247
37MP0002653_abnormal_ependyma_morphology1.23287888
38MP0005671_abnormal_response_to1.22599682
39MP0001529_abnormal_vocalization1.20072033
40MP0005551_abnormal_eye_electrophysiolog1.16291258
41MP0001905_abnormal_dopamine_level1.13897506
42MP0008995_early_reproductive_senescence1.13878753
43MP0002234_abnormal_pharynx_morphology1.13224795
44MP0004133_heterotaxia1.11867830
45MP0000026_abnormal_inner_ear1.10724923
46MP0001663_abnormal_digestive_system1.10137149
47MP0009333_abnormal_splenocyte_physiolog1.09900177
48MP0006276_abnormal_autonomic_nervous1.07968119
49MP0004742_abnormal_vestibular_system1.07414979
50MP0001485_abnormal_pinna_reflex1.06922643
51MP0003880_abnormal_central_pattern1.06392132
52MP0001440_abnormal_grooming_behavior1.06238745
53MP0005174_abnormal_tail_pigmentation1.05293054
54MP0003567_abnormal_fetal_cardiomyocyte1.05186155
55MP0008877_abnormal_DNA_methylation1.05003970
56MP0003011_delayed_dark_adaptation1.04108815
57MP0002736_abnormal_nociception_after1.03349692
58MP0003283_abnormal_digestive_organ1.02538442
59MP0002272_abnormal_nervous_system1.01766756
60MP0002102_abnormal_ear_morphology1.00910739
61MP0000778_abnormal_nervous_system1.00402697
62MP0001968_abnormal_touch/_nociception0.99450388
63MP0002233_abnormal_nose_morphology0.94804806
64MP0009745_abnormal_behavioral_response0.93331539
65MP0001835_abnormal_antigen_presentation0.92921946
66MP0009250_abnormal_appendicular_skeleto0.92054568
67MP0005195_abnormal_posterior_eye0.91966721
68MP0001346_abnormal_lacrimal_gland0.91914189
69MP0002160_abnormal_reproductive_system0.90743211
70MP0002249_abnormal_larynx_morphology0.89855239
71MP0005389_reproductive_system_phenotype0.88309381
72MP0000015_abnormal_ear_pigmentation0.87432354
73MP0000372_irregular_coat_pigmentation0.87055438
74MP0002752_abnormal_somatic_nervous0.86317197
75MP0005381_digestive/alimentary_phenotyp0.85956000
76MP0001919_abnormal_reproductive_system0.84704045
77MP0003195_calcinosis0.83426710
78MP0005075_abnormal_melanosome_morpholog0.82272454
79MP0001324_abnormal_eye_pigmentation0.81035906
80MP0003937_abnormal_limbs/digits/tail_de0.80184374
81MP0003186_abnormal_redox_activity0.80169659
82MP0005253_abnormal_eye_physiology0.78634423
83MP0005646_abnormal_pituitary_gland0.77138443
84MP0001970_abnormal_pain_threshold0.75847700
85MP0001963_abnormal_hearing_physiology0.72179019
86MP0002557_abnormal_social/conspecific_i0.71691224
87MP0002184_abnormal_innervation0.70452348
88MP0003755_abnormal_palate_morphology0.70168106
89MP0001286_abnormal_eye_development0.68696833
90MP0009764_decreased_sensitivity_to0.68449062
91MP0008872_abnormal_physiological_respon0.68190257
92MP0005391_vision/eye_phenotype0.67441371
93MP0000955_abnormal_spinal_cord0.67227186
94MP0001765_abnormal_ion_homeostasis0.66208284
95MP0005645_abnormal_hypothalamus_physiol0.65419653
96MP0002734_abnormal_mechanical_nocicepti0.64911865
97MP0003693_abnormal_embryo_hatching0.63080865
98MP0005379_endocrine/exocrine_gland_phen0.62925388
99MP0001727_abnormal_embryo_implantation0.61750486
100MP0001986_abnormal_taste_sensitivity0.60181902

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.58906186
2Macrocytic anemia (HP:0001972)4.50580427
3Abnormality of cells of the erythroid lineage (HP:0012130)4.40274001
4Septo-optic dysplasia (HP:0100842)4.07475364
5Acute necrotizing encephalopathy (HP:0006965)3.83834979
6Abnormal number of erythroid precursors (HP:0012131)3.78626588
7Pallor (HP:0000980)3.77167647
8Mitochondrial inheritance (HP:0001427)3.43812206
9Increased hepatocellular lipid droplets (HP:0006565)3.31107178
10Aplasia/Hypoplasia of the sacrum (HP:0008517)3.30524552
11Abnormal mitochondria in muscle tissue (HP:0008316)3.30059793
12Maternal diabetes (HP:0009800)3.29687301
13Lipid accumulation in hepatocytes (HP:0006561)3.20799324
14Acute encephalopathy (HP:0006846)3.15839154
15Congenital, generalized hypertrichosis (HP:0004540)3.15451929
16Progressive macrocephaly (HP:0004481)3.13481057
17Increased CSF lactate (HP:0002490)3.09011684
18Pancreatic cysts (HP:0001737)3.06193862
19Constricted visual fields (HP:0001133)2.97494680
20Abnormal ciliary motility (HP:0012262)2.92868255
21Renal Fanconi syndrome (HP:0001994)2.89521916
22Absent rod-and cone-mediated responses on ERG (HP:0007688)2.88559882
23Rib fusion (HP:0000902)2.82892919
24Concave nail (HP:0001598)2.79993135
25Round ear (HP:0100830)2.78478451
26Asplenia (HP:0001746)2.74442429
27Absent septum pellucidum (HP:0001331)2.73448419
283-Methylglutaconic aciduria (HP:0003535)2.70586647
29Increased intramyocellular lipid droplets (HP:0012240)2.66584543
30Pancreatic fibrosis (HP:0100732)2.63635271
31Congenital stationary night blindness (HP:0007642)2.59830730
32Aplasia/Hypoplasia of the spleen (HP:0010451)2.59184609
33Abnormality of the phalanges of the 2nd finger (HP:0009541)2.57324917
34Abnormal respiratory motile cilium physiology (HP:0012261)2.55924501
35Abnormal rod and cone electroretinograms (HP:0008323)2.55905556
36Abnormal respiratory motile cilium morphology (HP:0005938)2.49210968
37Abnormal respiratory epithelium morphology (HP:0012253)2.49210968
38Abnormal number of incisors (HP:0011064)2.47548985
39Hepatocellular necrosis (HP:0001404)2.47416121
40Hyperthyroidism (HP:0000836)2.42566711
41Exertional dyspnea (HP:0002875)2.40472275
42Molar tooth sign on MRI (HP:0002419)2.34318616
43Abnormality of midbrain morphology (HP:0002418)2.34318616
44Abnormality of the diencephalon (HP:0010662)2.32601217
45Increased muscle lipid content (HP:0009058)2.31160893
46Oligodontia (HP:0000677)2.30997272
47Optic disc pallor (HP:0000543)2.27587211
48Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.26569460
49Growth hormone deficiency (HP:0000824)2.25857259
50Optic nerve hypoplasia (HP:0000609)2.24987597
51Chronic sinusitis (HP:0011109)2.24729835
52Partial duplication of thumb phalanx (HP:0009944)2.24209697
53Myokymia (HP:0002411)2.22582637
54Abnormality of renal resorption (HP:0011038)2.20513661
55Nephronophthisis (HP:0000090)2.17198552
56Symphalangism affecting the phalanges of the hand (HP:0009773)2.16161873
57Stenosis of the external auditory canal (HP:0000402)2.15854259
58Abnormality of macular pigmentation (HP:0008002)2.10517186
59Hepatic necrosis (HP:0002605)2.10287767
60Partial duplication of the phalanx of hand (HP:0009999)2.10052310
61Cerebral edema (HP:0002181)2.09714173
62Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08540051
63Tubular atrophy (HP:0000092)2.07345593
64True hermaphroditism (HP:0010459)2.06973903
65Abnormal drinking behavior (HP:0030082)2.05579366
66Polydipsia (HP:0001959)2.05579366
67Abnormality of the septum pellucidum (HP:0007375)2.04424406
68Hypoplasia of the ulna (HP:0003022)2.04360062
69Abnormality of the middle phalanges of the toes (HP:0010183)2.02807484
70Abnormal hemoglobin (HP:0011902)2.01861180
71Abnormality of the phalanges of the 5th finger (HP:0004213)1.99569577
72Anencephaly (HP:0002323)1.98758761
73Abnormality of the 2nd finger (HP:0004100)1.98517883
74Attenuation of retinal blood vessels (HP:0007843)1.96169091
75Anophthalmia (HP:0000528)1.94704199
76Absent phalangeal crease (HP:0006109)1.93574673
77Nasal polyposis (HP:0100582)1.93313080
78Respiratory difficulties (HP:0002880)1.89906182
79Deformed tarsal bones (HP:0008119)1.89203573
80Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88520782
81Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88520782
82Abnormality of the renal medulla (HP:0100957)1.87470955
83Sclerocornea (HP:0000647)1.87322849
84Depressed nasal ridge (HP:0000457)1.85737299
85Pendular nystagmus (HP:0012043)1.84918995
86Type II lissencephaly (HP:0007260)1.84693867
87Decreased electroretinogram (ERG) amplitude (HP:0000654)1.84521691
88Striae distensae (HP:0001065)1.83185104
89Triphalangeal thumb (HP:0001199)1.79866631
90Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.79181045
91Cystic liver disease (HP:0006706)1.78413560
92Absent thumb (HP:0009777)1.73516223
93Volvulus (HP:0002580)1.72350884
94Agitation (HP:0000713)1.71277894
95Increased serum lactate (HP:0002151)1.71231046
96Microretrognathia (HP:0000308)1.69906852
97Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.68727928
98Esophageal atresia (HP:0002032)1.68570099
99Calcaneovalgus deformity (HP:0001848)1.68492708
100Severe visual impairment (HP:0001141)1.67078149

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK194.29553696
2MAP3K132.65089577
3WNK42.60501369
4PASK2.58769814
5TLK12.55507587
6KIT2.23776182
7ZAK2.18796830
8BMPR22.16029667
9TIE12.05513201
10MAP3K121.97284349
11DYRK21.96263543
12BCKDK1.78987614
13STK161.77948130
14ADRBK21.75205510
15TEC1.70174525
16NME21.64925291
17CDK81.60961412
18PIK3CA1.60912911
19MAP3K91.58504470
20MUSK1.56974969
21MAP2K21.48489268
22EPHB21.46724366
23CDC71.43413384
24IKBKB1.42667890
25MAP4K11.41756483
26WNK31.36030160
27GRK11.35007705
28CAMKK11.31977489
29FES1.23190261
30OXSR11.19411699
31LRRK21.19064610
32OBSCN1.18197905
33ITK1.17316994
34ILK1.12497470
35BMPR1B1.11260778
36NEK21.06135162
37DAPK31.04457930
38ABL21.03061399
39CAMKK21.03013624
40BTK1.01237406
41BRAF0.96408862
42INSRR0.94826965
43RPS6KA60.86959264
44CHEK20.85184221
45PRKCG0.84622523
46PNCK0.84288338
47CASK0.82138130
48MAPK130.81676999
49CAMK10.80961981
50MYLK0.79600475
51SGK2230.78825681
52SGK4940.78825681
53FRK0.78622064
54MAPK150.78354272
55LIMK10.77519045
56CSK0.76857326
57STK110.75925111
58CAMK1G0.73695464
59PKN10.73163657
60MOS0.72126863
61PRKCQ0.70782439
62SYK0.68931822
63PIK3CG0.68888818
64PRKACA0.67729051
65PIM10.67396390
66MAP3K70.66246506
67RPS6KL10.66238898
68RPS6KC10.66238898
69ADRBK10.65671315
70CAMK1D0.64772291
71NUAK10.64262045
72SGK10.63155567
73PLK40.61705664
74TNK20.60495675
75CSNK2A20.60334986
76RPS6KA50.58280336
77NME10.57759697
78PRKCZ0.57110321
79EPHA40.55910171
80PHKG10.53725491
81PHKG20.53725491
82DYRK1B0.52619767
83TXK0.52216212
84AURKA0.50019625
85GRK60.49664792
86SIK20.47443307
87DYRK1A0.47083308
88WNK10.46558667
89LYN0.46401672
90STK390.45835782
91SGK20.45052041
92TGFBR10.44802992
93PRKCA0.44323733
94TAOK30.44262038
95GRK70.44152966
96NEK10.42480777
97CSNK2A10.42223678
98DYRK30.42089572
99MAP4K20.41813518
100AURKB0.41512838

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.69219039
2Oxidative phosphorylation_Homo sapiens_hsa001904.47343979
3Parkinsons disease_Homo sapiens_hsa050123.69760787
4Asthma_Homo sapiens_hsa053103.47183251
5Graft-versus-host disease_Homo sapiens_hsa053322.76952904
6Cardiac muscle contraction_Homo sapiens_hsa042602.68642270
7Alzheimers disease_Homo sapiens_hsa050102.62067782
8Huntingtons disease_Homo sapiens_hsa050162.59320716
9Allograft rejection_Homo sapiens_hsa053302.53517300
10Autoimmune thyroid disease_Homo sapiens_hsa053202.50352337
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.49572401
12Sulfur relay system_Homo sapiens_hsa041222.35156869
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.31725381
14Type I diabetes mellitus_Homo sapiens_hsa049402.01809258
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77071476
16Caffeine metabolism_Homo sapiens_hsa002321.57854900
17Phototransduction_Homo sapiens_hsa047441.47029226
18Protein export_Homo sapiens_hsa030601.46586270
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40591723
20RNA polymerase_Homo sapiens_hsa030201.36188786
21Viral myocarditis_Homo sapiens_hsa054161.35125296
22Linoleic acid metabolism_Homo sapiens_hsa005911.33094349
23Staphylococcus aureus infection_Homo sapiens_hsa051501.30244106
24RNA degradation_Homo sapiens_hsa030181.22172001
25Rheumatoid arthritis_Homo sapiens_hsa053231.10223767
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07677655
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07434062
28Arachidonic acid metabolism_Homo sapiens_hsa005901.03553732
29Antigen processing and presentation_Homo sapiens_hsa046121.03165444
30Proteasome_Homo sapiens_hsa030501.01396505
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98555770
32Systemic lupus erythematosus_Homo sapiens_hsa053220.96361926
33Olfactory transduction_Homo sapiens_hsa047400.85369859
34Chemical carcinogenesis_Homo sapiens_hsa052040.84415802
35Maturity onset diabetes of the young_Homo sapiens_hsa049500.84161575
36Tyrosine metabolism_Homo sapiens_hsa003500.82581451
37Nicotine addiction_Homo sapiens_hsa050330.82068537
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81993901
39Leishmaniasis_Homo sapiens_hsa051400.81483639
40Tryptophan metabolism_Homo sapiens_hsa003800.78810142
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77718093
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74631981
43Nitrogen metabolism_Homo sapiens_hsa009100.73381733
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72304327
45Fanconi anemia pathway_Homo sapiens_hsa034600.71727760
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.62047634
47Pyrimidine metabolism_Homo sapiens_hsa002400.61185728
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.60102729
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59702699
50Retinol metabolism_Homo sapiens_hsa008300.58553446
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57975892
52Basal cell carcinoma_Homo sapiens_hsa052170.56870490
53Fat digestion and absorption_Homo sapiens_hsa049750.56714090
54Morphine addiction_Homo sapiens_hsa050320.52489425
55Homologous recombination_Homo sapiens_hsa034400.52122094
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51331466
57Regulation of autophagy_Homo sapiens_hsa041400.50053305
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47599442
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44475014
60Notch signaling pathway_Homo sapiens_hsa043300.43688304
61Peroxisome_Homo sapiens_hsa041460.43267684
62beta-Alanine metabolism_Homo sapiens_hsa004100.40249232
63Ether lipid metabolism_Homo sapiens_hsa005650.40020955
64One carbon pool by folate_Homo sapiens_hsa006700.39205206
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38127495
66Metabolic pathways_Homo sapiens_hsa011000.37240369
67Spliceosome_Homo sapiens_hsa030400.36829087
68Basal transcription factors_Homo sapiens_hsa030220.35472104
69Purine metabolism_Homo sapiens_hsa002300.35318587
70Melanoma_Homo sapiens_hsa052180.35019508
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32442453
72Sulfur metabolism_Homo sapiens_hsa009200.30287364
73Folate biosynthesis_Homo sapiens_hsa007900.30179449
74Selenocompound metabolism_Homo sapiens_hsa004500.29986094
75Hedgehog signaling pathway_Homo sapiens_hsa043400.29244114
76Glutathione metabolism_Homo sapiens_hsa004800.28580378
77Taste transduction_Homo sapiens_hsa047420.26919922
78Hematopoietic cell lineage_Homo sapiens_hsa046400.26689142
79Primary immunodeficiency_Homo sapiens_hsa053400.24059348
80DNA replication_Homo sapiens_hsa030300.23863845
81Mismatch repair_Homo sapiens_hsa034300.23138970
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21937708
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.18882567
84Collecting duct acid secretion_Homo sapiens_hsa049660.18872997
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.18600090
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18366618
87GABAergic synapse_Homo sapiens_hsa047270.17305805
88Vitamin digestion and absorption_Homo sapiens_hsa049770.16582983
89RNA transport_Homo sapiens_hsa030130.15592680
90Axon guidance_Homo sapiens_hsa043600.14935221
91Serotonergic synapse_Homo sapiens_hsa047260.14424729
92Insulin secretion_Homo sapiens_hsa049110.14194669
93Malaria_Homo sapiens_hsa051440.12575737
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.12292112
95Fatty acid degradation_Homo sapiens_hsa000710.11332198
96Cholinergic synapse_Homo sapiens_hsa047250.11199748
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.10966406
98cAMP signaling pathway_Homo sapiens_hsa040240.09281105
99Histidine metabolism_Homo sapiens_hsa003400.08361825
100Vitamin B6 metabolism_Homo sapiens_hsa007500.08010151

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