ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.33902630
2	ribosomal small subunit assembly (GO:0000028)	8.02194569
3	translational termination (GO:0006415)	7.92758695
4	ribosomal small subunit biogenesis (GO:0042274)	7.54836811
5	maturation of SSU-rRNA (GO:0030490)	6.76979535
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.66417429
7	cotranslational protein targeting to membrane (GO:0006613)	6.62693497
8	translational elongation (GO:0006414)	6.59412955
9	protein targeting to ER (GO:0045047)	6.54941985
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.23880843
11	protein localization to endoplasmic reticulum (GO:0070972)	6.17104835
12	ATP synthesis coupled proton transport (GO:0015986)	6.14533682
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.14533682
14	cellular protein complex disassembly (GO:0043624)	6.04708934
15	viral life cycle (GO:0019058)	5.92762043
16	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.80108600
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.63663358
18	behavioral response to nicotine (GO:0035095)	5.22315748
19	protein complex disassembly (GO:0043241)	5.11753303
20	translational initiation (GO:0006413)	5.10021630
21	protein neddylation (GO:0045116)	5.03654639
22	macromolecular complex disassembly (GO:0032984)	4.84720484
23	chaperone-mediated protein transport (GO:0072321)	4.77571309
24	ribosomal large subunit biogenesis (GO:0042273)	4.72628662
25	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.61354537
26	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.59912273
27	protein targeting to membrane (GO:0006612)	4.41875969
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.26701616
29	NADH dehydrogenase complex assembly (GO:0010257)	4.26701616
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.26701616
31	respiratory electron transport chain (GO:0022904)	4.20291442
32	electron transport chain (GO:0022900)	4.17182118
33	substrate-independent telencephalic tangential migration (GO:0021826)	4.10732271
34	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.10732271
35	protein complex biogenesis (GO:0070271)	4.06450572
36	translation (GO:0006412)	4.02565125
37	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.95831243
38	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.92838813
39	cell proliferation in forebrain (GO:0021846)	3.77214947
40	mRNA catabolic process (GO:0006402)	3.69083639
41	mitochondrial respiratory chain complex assembly (GO:0033108)	3.66962866
42	ncRNA 3-end processing (GO:0043628)	3.54602965
43	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.52361982
44	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.52361982
45	negative regulation of heart rate (GO:0010459)	3.46709102
46	ATP biosynthetic process (GO:0006754)	3.39224055
47	cellular component biogenesis (GO:0044085)	3.32756279
48	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.29994173
49	pyrimidine nucleotide catabolic process (GO:0006244)	3.29555309
50	RNA catabolic process (GO:0006401)	3.28759000
51	ribonucleoprotein complex biogenesis (GO:0022613)	3.28707312
52	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.26341213
53	neuron fate determination (GO:0048664)	3.20330333
54	central nervous system myelination (GO:0022010)	3.19633400
55	axon ensheathment in central nervous system (GO:0032291)	3.19633400
56	spinal cord association neuron differentiation (GO:0021527)	3.18591348
57	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.15819725
58	hydrogen ion transmembrane transport (GO:1902600)	3.13591655
59	somite development (GO:0061053)	3.13350851
60	pyrimidine nucleobase catabolic process (GO:0006208)	2.94712452
61	establishment of protein localization to membrane (GO:0090150)	2.93973233
62	pattern specification involved in kidney development (GO:0061004)	2.88812596
63	base-excision repair, AP site formation (GO:0006285)	2.88313582
64	GTP biosynthetic process (GO:0006183)	2.85545546
65	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.82596921
66	protein targeting (GO:0006605)	2.82177352
67	tongue development (GO:0043586)	2.81727504
68	nonmotile primary cilium assembly (GO:0035058)	2.79312599
69	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.77986067
70	water-soluble vitamin biosynthetic process (GO:0042364)	2.75365364
71	synaptic transmission, cholinergic (GO:0007271)	2.74844575
72	proton transport (GO:0015992)	2.74080150
73	thalamus development (GO:0021794)	2.73244804
74	segment specification (GO:0007379)	2.71420513
75	hydrogen transport (GO:0006818)	2.69879347
76	auditory receptor cell differentiation (GO:0042491)	2.68785826
77	epithelial cilium movement (GO:0003351)	2.64709606
78	response to pheromone (GO:0019236)	2.64518791
79	hypothalamus development (GO:0021854)	2.61492820
80	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.59958524
81	establishment of protein localization to organelle (GO:0072594)	2.58387262
82	deoxyribose phosphate catabolic process (GO:0046386)	2.57369548
83	dentate gyrus development (GO:0021542)	2.54988763
84	left/right axis specification (GO:0070986)	2.53583968
85	cardiovascular system development (GO:0072358)	2.52056262
86	negative regulation of response to food (GO:0032096)	2.51461686
87	negative regulation of appetite (GO:0032099)	2.51461686
88	nucleobase catabolic process (GO:0046113)	2.50371250
89	regulation of cilium movement (GO:0003352)	2.49990895
90	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.49670510
91	deoxyribonucleotide catabolic process (GO:0009264)	2.47781178
92	axonemal dynein complex assembly (GO:0070286)	2.43493042
93	GPI anchor metabolic process (GO:0006505)	2.43344545
94	protein localization to membrane (GO:0072657)	2.43014297
95	UTP biosynthetic process (GO:0006228)	2.42944613
96	neuronal action potential propagation (GO:0019227)	2.38009707
97	regulation of action potential (GO:0098900)	2.36697496
98	nucleoside triphosphate biosynthetic process (GO:0009142)	2.35280874
99	DNA deamination (GO:0045006)	2.35263025
100	regulation of microtubule-based movement (GO:0060632)	2.35043736

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.27820097
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.90452649
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.73956743
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.74501622
5	VDR_22108803_ChIP-Seq_LS180_Human	2.58505046
6	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.50927573
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.45675306
8	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.43035592
9	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.37425350
10	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.34434043
11	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.30191891
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.24023265
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.23247326
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.05148637
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.03666375
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.93015193
17	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.92741474
18	MYC_18940864_ChIP-ChIP_HL60_Human	1.92224001
19	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.89249595
20	IRF1_19129219_ChIP-ChIP_H3396_Human	1.87397700
21	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.80715074
22	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.73885884
23	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.71190410
24	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.70054347
25	RNF2_27304074_Chip-Seq_NSC_Mouse	1.62743012
26	REST_21632747_ChIP-Seq_MESCs_Mouse	1.60824946
27	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.60254773
28	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.58969889
29	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.58253221
30	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.58177222
31	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.54228455
32	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.53703979
33	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.53569333
34	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.50429341
35	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.48235209
36	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.48235209
37	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.47441251
38	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.46798185
39	FUS_26573619_Chip-Seq_HEK293_Human	1.46115347
40	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.45782727
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.38252074
42	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.37893950
43	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.35972807
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.35087889
45	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.32975847
46	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.32747456
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32564873
48	EWS_26573619_Chip-Seq_HEK293_Human	1.28529483
49	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.27937865
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.27633676
51	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.26521684
52	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.26453740
53	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.24252253
54	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.23566402
55	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.21705615
56	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.21009244
57	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.19885226
58	TAF2_19829295_ChIP-Seq_ESCs_Human	1.19096135
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.16862810
60	TTF2_22483619_ChIP-Seq_HELA_Human	1.15666432
61	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.13049834
62	NCOR_22424771_ChIP-Seq_293T_Human	1.12909908
63	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.10822284
64	P300_19829295_ChIP-Seq_ESCs_Human	1.10278663
65	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.08908439
66	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.08697734
67	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.08337207
68	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.07959927
69	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.07491535
70	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07491535
71	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.06404699
72	ERA_21632823_ChIP-Seq_H3396_Human	1.06146987
73	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.05207275
74	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03393805
75	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03393805
76	GBX2_23144817_ChIP-Seq_PC3_Human	1.02989503
77	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02944627
78	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.02105338
79	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.01166219
80	CBP_20019798_ChIP-Seq_JUKART_Human	0.98341310
81	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.98341310
82	VDR_23849224_ChIP-Seq_CD4+_Human	0.98017051
83	CTCF_27219007_Chip-Seq_Bcells_Human	0.97901128
84	ELK1_19687146_ChIP-ChIP_HELA_Human	0.97878777
85	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.97146394
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96945248
87	XRN2_22483619_ChIP-Seq_HELA_Human	0.96555608
88	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.94643000
89	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.93369734
90	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.93056658
91	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.92822679
92	TAF15_26573619_Chip-Seq_HEK293_Human	0.91388229
93	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.91083379
94	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.90622783
95	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.90161399
96	SOX2_19829295_ChIP-Seq_ESCs_Human	0.89768870
97	NANOG_19829295_ChIP-Seq_ESCs_Human	0.89768870
98	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.89758200
99	MYC_19829295_ChIP-Seq_ESCs_Human	0.89329128
100	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.88705445

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.94221474
2	MP0006292_abnormal_olfactory_placode	4.18679527
3	MP0003787_abnormal_imprinting	3.22404819
4	MP0003880_abnormal_central_pattern	2.63011731
5	MP0003122_maternal_imprinting	2.56565030
6	MP0003646_muscle_fatigue	2.36292676
7	MP0008877_abnormal_DNA_methylation	2.34864967
8	MP0008789_abnormal_olfactory_epithelium	2.13262576
9	MP0003123_paternal_imprinting	2.11140415
10	MP0003121_genomic_imprinting	2.05239798
11	MP0001485_abnormal_pinna_reflex	2.02539049
12	MP0002653_abnormal_ependyma_morphology	1.93369425
13	MP0004142_abnormal_muscle_tone	1.91200242
14	MP0001986_abnormal_taste_sensitivity	1.88877863
15	MP0001293_anophthalmia	1.84481164
16	MP0000566_synostosis	1.83970140
17	MP0005499_abnormal_olfactory_system	1.76723725
18	MP0005394_taste/olfaction_phenotype	1.76723725
19	MP0005646_abnormal_pituitary_gland	1.76670051
20	MP0002163_abnormal_gland_morphology	1.73630928
21	MP0005377_hearing/vestibular/ear_phenot	1.71362322
22	MP0003878_abnormal_ear_physiology	1.71362322
23	MP0006276_abnormal_autonomic_nervous	1.66950235
24	MP0000778_abnormal_nervous_system	1.66188595
25	MP0000049_abnormal_middle_ear	1.63110513
26	MP0004885_abnormal_endolymph	1.58003035
27	MP0001968_abnormal_touch/_nociception	1.56434920
28	MP0004742_abnormal_vestibular_system	1.51606115
29	MP0002272_abnormal_nervous_system	1.49747373
30	MP0002234_abnormal_pharynx_morphology	1.49248414
31	MP0005645_abnormal_hypothalamus_physiol	1.44656700
32	MP0002837_dystrophic_cardiac_calcinosis	1.43656045
33	MP0004145_abnormal_muscle_electrophysio	1.43408228
34	MP0009745_abnormal_behavioral_response	1.37900748
35	MP0001440_abnormal_grooming_behavior	1.37877796
36	MP0003567_abnormal_fetal_cardiomyocyte	1.37542961
37	MP0005423_abnormal_somatic_nervous	1.37019475
38	MP0002736_abnormal_nociception_after	1.35923702
39	MP0002638_abnormal_pupillary_reflex	1.34738575
40	MP0008872_abnormal_physiological_respon	1.31709849
41	MP0001348_abnormal_lacrimal_gland	1.29182903
42	MP0008995_early_reproductive_senescence	1.29008344
43	MP0001529_abnormal_vocalization	1.28690189
44	MP0001905_abnormal_dopamine_level	1.27993823
45	MP0005389_reproductive_system_phenotype	1.25092993
46	MP0000631_abnormal_neuroendocrine_gland	1.24824570
47	MP0002938_white_spotting	1.24803887
48	MP0005551_abnormal_eye_electrophysiolog	1.22562722
49	MP0004133_heterotaxia	1.21962081
50	MP0001970_abnormal_pain_threshold	1.21354250
51	MP0006072_abnormal_retinal_apoptosis	1.20048496
52	MP0002160_abnormal_reproductive_system	1.17793484
53	MP0002095_abnormal_skin_pigmentation	1.16772433
54	MP0002822_catalepsy	1.13933466
55	MP0000372_irregular_coat_pigmentation	1.13759075
56	MP0002557_abnormal_social/conspecific_i	1.11158812
57	MP0008875_abnormal_xenobiotic_pharmacok	1.10809803
58	MP0000026_abnormal_inner_ear	1.09626295
59	MP0005084_abnormal_gallbladder_morpholo	1.09363863
60	MP0002733_abnormal_thermal_nociception	1.09126309
61	MP0005195_abnormal_posterior_eye	1.08915189
62	MP0001919_abnormal_reproductive_system	1.07968521
63	MP0002876_abnormal_thyroid_physiology	1.07318036
64	MP0003635_abnormal_synaptic_transmissio	1.06761563
65	MP0002184_abnormal_innervation	1.05613955
66	MP0002063_abnormal_learning/memory/cond	1.05509803
67	MP0002572_abnormal_emotion/affect_behav	1.03372405
68	MP0002752_abnormal_somatic_nervous	1.01347138
69	MP0003136_yellow_coat_color	1.00321231
70	MP0003879_abnormal_hair_cell	0.97427252
71	MP0009046_muscle_twitch	0.96843292
72	MP0005174_abnormal_tail_pigmentation	0.96161555
73	MP0000955_abnormal_spinal_cord	0.96092832
74	MP0010030_abnormal_orbit_morphology	0.94969599
75	MP0001486_abnormal_startle_reflex	0.94889768
76	MP0002064_seizures	0.94887609
77	MP0001188_hyperpigmentation	0.94642848
78	MP0003283_abnormal_digestive_organ	0.93756673
79	MP0005075_abnormal_melanosome_morpholog	0.93634266
80	MP0001502_abnormal_circadian_rhythm	0.91704673
81	MP0005379_endocrine/exocrine_gland_phen	0.91487853
82	MP0003890_abnormal_embryonic-extraembry	0.91179209
83	MP0002735_abnormal_chemical_nociception	0.90734565
84	MP0001963_abnormal_hearing_physiology	0.88558485
85	MP0002233_abnormal_nose_morphology	0.87506650
86	MP0001984_abnormal_olfaction	0.86660861
87	MP0002067_abnormal_sensory_capabilities	0.83513959
88	MP0003011_delayed_dark_adaptation	0.82590411
89	MP0002210_abnormal_sex_determination	0.81951191
90	MP0001727_abnormal_embryo_implantation	0.81730349
91	MP0003119_abnormal_digestive_system	0.78736749
92	MP0003315_abnormal_perineum_morphology	0.76317224
93	MP0001286_abnormal_eye_development	0.75979875
94	MP0002734_abnormal_mechanical_nocicepti	0.74915950
95	MP0005253_abnormal_eye_physiology	0.73659194
96	MP0002882_abnormal_neuron_morphology	0.72439275
97	MP0002102_abnormal_ear_morphology	0.72115785
98	MP0003937_abnormal_limbs/digits/tail_de	0.69805495
99	MP0004147_increased_porphyrin_level	0.69557915
100	MP0005085_abnormal_gallbladder_physiolo	0.68958793

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.01442195
2	Abnormality of cells of the erythroid lineage (HP:0012130)	5.03280141
3	Acute necrotizing encephalopathy (HP:0006965)	4.43606111
4	Macrocytic anemia (HP:0001972)	4.39546242
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.89819478
6	Acute encephalopathy (HP:0006846)	3.89663084
7	Abnormal number of erythroid precursors (HP:0012131)	3.87524186
8	Mitochondrial inheritance (HP:0001427)	3.86891612
9	Pallor (HP:0000980)	3.83410726
10	Progressive macrocephaly (HP:0004481)	3.67191343
11	Septo-optic dysplasia (HP:0100842)	3.54595018
12	Abnormality of midbrain morphology (HP:0002418)	3.54502472
13	Molar tooth sign on MRI (HP:0002419)	3.54502472
14	Abnormal hemoglobin (HP:0011902)	3.31119109
15	Increased CSF lactate (HP:0002490)	3.30380083
16	3-Methylglutaconic aciduria (HP:0003535)	3.15853574
17	Increased hepatocellular lipid droplets (HP:0006565)	3.14337235
18	Pancreatic fibrosis (HP:0100732)	3.12970046
19	Hepatocellular necrosis (HP:0001404)	3.05246709
20	Rib fusion (HP:0000902)	2.99326496
21	Lipid accumulation in hepatocytes (HP:0006561)	2.87113691
22	Stenosis of the external auditory canal (HP:0000402)	2.79879425
23	Pancreatic cysts (HP:0001737)	2.74879735
24	Renal Fanconi syndrome (HP:0001994)	2.69874338
25	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.68435864
26	Absent/shortened dynein arms (HP:0200106)	2.63869024
27	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.63869024
28	Nephronophthisis (HP:0000090)	2.59824985
29	Hepatic necrosis (HP:0002605)	2.58206701
30	True hermaphroditism (HP:0010459)	2.52191026
31	Sclerocornea (HP:0000647)	2.50524282
32	Myokymia (HP:0002411)	2.48732654
33	Optic disc pallor (HP:0000543)	2.47695767
34	Exertional dyspnea (HP:0002875)	2.47152127
35	Abnormal ciliary motility (HP:0012262)	2.45461792
36	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.44604443
37	Increased intramyocellular lipid droplets (HP:0012240)	2.43052506
38	Hyperglycinemia (HP:0002154)	2.42253580
39	Medial flaring of the eyebrow (HP:0010747)	2.41766922
40	Abnormality of renal resorption (HP:0011038)	2.40885783
41	Cerebral edema (HP:0002181)	2.40686731
42	Asplenia (HP:0001746)	2.38857843
43	Congenital stationary night blindness (HP:0007642)	2.37502752
44	Pendular nystagmus (HP:0012043)	2.35736334
45	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.34491387
46	Anophthalmia (HP:0000528)	2.27277560
47	Abnormal rod and cone electroretinograms (HP:0008323)	2.22494434
48	Supernumerary spleens (HP:0009799)	2.18375798
49	Absent thumb (HP:0009777)	2.17122237
50	Congenital, generalized hypertrichosis (HP:0004540)	2.16779943
51	Abnormal respiratory motile cilium physiology (HP:0012261)	2.15912491
52	Agitation (HP:0000713)	2.15704354
53	Optic nerve hypoplasia (HP:0000609)	2.14788479
54	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.13728706
55	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.13728706
56	Adrenal hypoplasia (HP:0000835)	2.10912654
57	Abnormal respiratory epithelium morphology (HP:0012253)	2.09571664
58	Abnormal respiratory motile cilium morphology (HP:0005938)	2.09571664
59	Male pseudohermaphroditism (HP:0000037)	2.08180569
60	Anencephaly (HP:0002323)	2.08174626
61	Depressed nasal ridge (HP:0000457)	2.07548622
62	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.04923473
63	Gait imbalance (HP:0002141)	2.04840111
64	Type 2 muscle fiber atrophy (HP:0003554)	2.04526279
65	Abnormality of the renal medulla (HP:0100957)	2.02675032
66	Type II lissencephaly (HP:0007260)	2.01564898
67	Leukodystrophy (HP:0002415)	2.01260744
68	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.01069277
69	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.99551561
70	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.95160363
71	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.95160363
72	Increased muscle lipid content (HP:0009058)	1.92755212
73	Cystic liver disease (HP:0006706)	1.91526930
74	Growth hormone deficiency (HP:0000824)	1.91073599
75	Abnormality of DNA repair (HP:0003254)	1.89924951
76	Abnormality of the corticospinal tract (HP:0002492)	1.89892130
77	Postaxial foot polydactyly (HP:0001830)	1.89886434
78	Oligodactyly (hands) (HP:0001180)	1.88674520
79	Congenital primary aphakia (HP:0007707)	1.88202581
80	Methylmalonic acidemia (HP:0002912)	1.87010498
81	Maternal diabetes (HP:0009800)	1.84929763
82	Hypoplasia of the ulna (HP:0003022)	1.84406084
83	Colon cancer (HP:0003003)	1.84373342
84	Abolished electroretinogram (ERG) (HP:0000550)	1.83443937
85	Absent septum pellucidum (HP:0001331)	1.83231622
86	Lactic acidosis (HP:0003128)	1.81898039
87	Tachypnea (HP:0002789)	1.73656418
88	Increased serum lactate (HP:0002151)	1.71807983
89	Triphalangeal thumb (HP:0001199)	1.71505765
90	Limb dystonia (HP:0002451)	1.70316953
91	Abnormality of the labia minora (HP:0012880)	1.67399373
92	Respiratory failure (HP:0002878)	1.66763006
93	Poor suck (HP:0002033)	1.66591153
94	Hyperthyroidism (HP:0000836)	1.66152481
95	Porencephaly (HP:0002132)	1.65718700
96	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.63938698
97	Occipital encephalocele (HP:0002085)	1.63822989
98	Lethargy (HP:0001254)	1.63593442
99	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.63463677
100	Congenital malformation of the right heart (HP:0011723)	1.62927869

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	4.51138057
2	TIE1	3.27609537
3	GRK1	2.87636887
4	ADRBK2	2.70526160
5	WNK4	2.55397181
6	DYRK2	2.51420896
7	STK16	2.16208410
8	TAOK3	2.06016947
9	NUAK1	2.04485311
10	INSRR	1.99908584
11	PINK1	1.85953038
12	WNK3	1.83841677
13	TLK1	1.78174502
14	EPHA4	1.60795528
15	ABL2	1.53382456
16	BMPR2	1.52741914
17	EPHB2	1.51548421
18	BCKDK	1.42408383
19	PRKCG	1.41336537
20	FRK	1.36480641
21	STK39	1.30177150
22	ZAK	1.26760085
23	OXSR1	1.25494043
24	MAP4K2	1.25127644
25	MARK1	1.24213029
26	LRRK2	1.20027452
27	WNK1	1.14130412
28	CASK	1.13780013
29	TXK	1.11583192
30	PIK3CA	1.09717003
31	MINK1	1.08719858
32	BMPR1B	1.08073245
33	CSNK1G2	1.03353883
34	MAP2K7	1.02489246
35	NTRK2	1.01009806
36	MAP3K4	0.98600070
37	MAPK15	0.93820762
38	STK11	0.93317712
39	NME2	0.89825529
40	ADRBK1	0.87436286
41	PNCK	0.86309750
42	SIK2	0.85445672
43	MAP3K12	0.83083407
44	TYRO3	0.82565191
45	CAMK1	0.81797791
46	PRKACA	0.81102662
47	CSNK2A2	0.79881431
48	CSNK1E	0.78945256
49	TEC	0.77181422
50	DAPK3	0.76793429
51	CSNK1G1	0.75436679
52	CDC7	0.75142634
53	VRK2	0.74104377
54	RPS6KA6	0.73831141
55	WEE1	0.72026052
56	MAPK13	0.72024666
57	PAK3	0.72008110
58	BTK	0.71724385
59	MYLK	0.71355501
60	CSNK1G3	0.71118732
61	OBSCN	0.70475224
62	NEK2	0.69325771
63	NEK1	0.69008768
64	AURKB	0.68665744
65	PLK4	0.68304227
66	PRKCH	0.67156714
67	PHKG1	0.64783460
68	PHKG2	0.64783460
69	CSNK2A1	0.64352913
70	CAMK2A	0.62977531
71	TNIK	0.62301485
72	PRKCQ	0.60108528
73	CHEK2	0.58759609
74	VRK1	0.58727101
75	CSNK1A1	0.57306399
76	BRSK1	0.57264140
77	ERBB2	0.55391410
78	NTRK3	0.54949566
79	RPS6KC1	0.54442237
80	RPS6KL1	0.54442237
81	AURKA	0.53508640
82	DYRK1B	0.52363755
83	DYRK3	0.52085638
84	RPS6KA5	0.51183494
85	CAMKK2	0.50497734
86	PLK1	0.50229698
87	IKBKB	0.50107829
88	DMPK	0.50029831
89	PRKCA	0.49466058
90	DYRK1A	0.48366066
91	PIM2	0.46674879
92	PRKACG	0.46117643
93	ERBB3	0.45487959
94	PRKCE	0.45294321
95	CAMK2D	0.45079786
96	CDK8	0.44338495
97	PRKG1	0.43646625
98	ILK	0.42408848
99	CDK11A	0.41714287
100	PKN1	0.41696054

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.68446030
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.48305561
3	Parkinsons disease_Homo sapiens_hsa05012	3.76195545
4	Asthma_Homo sapiens_hsa05310	3.08663909
5	Cardiac muscle contraction_Homo sapiens_hsa04260	3.03724898
6	Alzheimers disease_Homo sapiens_hsa05010	2.65159679
7	Huntingtons disease_Homo sapiens_hsa05016	2.62850805
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.46591216
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.22574288
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.99397685
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.93075520
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.86882081
13	Nicotine addiction_Homo sapiens_hsa05033	1.75789317
14	Protein export_Homo sapiens_hsa03060	1.67493352
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.67242109
16	RNA polymerase_Homo sapiens_hsa03020	1.63360783
17	Homologous recombination_Homo sapiens_hsa03440	1.62631694
18	Allograft rejection_Homo sapiens_hsa05330	1.60567021
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.56321409
20	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.56206429
21	Phototransduction_Homo sapiens_hsa04744	1.33854502
22	Graft-versus-host disease_Homo sapiens_hsa05332	1.28588389
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.25155272
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.18784286
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.18015024
26	Proteasome_Homo sapiens_hsa03050	1.16045721
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.14390128
28	Type I diabetes mellitus_Homo sapiens_hsa04940	1.14119594
29	Morphine addiction_Homo sapiens_hsa05032	0.98235305
30	Fat digestion and absorption_Homo sapiens_hsa04975	0.97926233
31	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.97870889
32	RNA degradation_Homo sapiens_hsa03018	0.97296251
33	Ether lipid metabolism_Homo sapiens_hsa00565	0.96041976
34	Butanoate metabolism_Homo sapiens_hsa00650	0.95892322
35	Nucleotide excision repair_Homo sapiens_hsa03420	0.95770517
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.89778578
37	Nitrogen metabolism_Homo sapiens_hsa00910	0.89657029
38	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.87346977
39	Olfactory transduction_Homo sapiens_hsa04740	0.83918983
40	One carbon pool by folate_Homo sapiens_hsa00670	0.83667955
41	Caffeine metabolism_Homo sapiens_hsa00232	0.82673494
42	Basal transcription factors_Homo sapiens_hsa03022	0.81014665
43	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.79613947
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.79099699
45	Steroid biosynthesis_Homo sapiens_hsa00100	0.76366934
46	GABAergic synapse_Homo sapiens_hsa04727	0.76229738
47	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.74983654
48	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.72375690
49	Pyrimidine metabolism_Homo sapiens_hsa00240	0.71957022
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71383057
51	Taste transduction_Homo sapiens_hsa04742	0.70627282
52	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.69485804
53	Tryptophan metabolism_Homo sapiens_hsa00380	0.69362020
54	Sulfur relay system_Homo sapiens_hsa04122	0.68783207
55	Insulin secretion_Homo sapiens_hsa04911	0.68239210
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.67903093
57	Metabolic pathways_Homo sapiens_hsa01100	0.65005733
58	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.62345589
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60679380
60	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.59354455
61	Rheumatoid arthritis_Homo sapiens_hsa05323	0.58603171
62	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.57813981
63	Purine metabolism_Homo sapiens_hsa00230	0.57435004
64	Basal cell carcinoma_Homo sapiens_hsa05217	0.57342012
65	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.55910709
66	Peroxisome_Homo sapiens_hsa04146	0.54056436
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.52796405
68	Mismatch repair_Homo sapiens_hsa03430	0.52406130
69	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.51923591
70	Retinol metabolism_Homo sapiens_hsa00830	0.51211817
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50675975
72	Serotonergic synapse_Homo sapiens_hsa04726	0.50528958
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.49781567
74	Propanoate metabolism_Homo sapiens_hsa00640	0.49291054
75	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.48392361
76	Salivary secretion_Homo sapiens_hsa04970	0.46491154
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46338075
78	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.46188406
79	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.45500569
80	RNA transport_Homo sapiens_hsa03013	0.45466769
81	Glutamatergic synapse_Homo sapiens_hsa04724	0.45421580
82	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.41869639
83	Collecting duct acid secretion_Homo sapiens_hsa04966	0.41105959
84	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.40684321
85	Base excision repair_Homo sapiens_hsa03410	0.40585071
86	Spliceosome_Homo sapiens_hsa03040	0.39887910
87	Viral myocarditis_Homo sapiens_hsa05416	0.39867311
88	Circadian entrainment_Homo sapiens_hsa04713	0.39071629
89	Pancreatic secretion_Homo sapiens_hsa04972	0.38318729
90	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.37956030
91	Cholinergic synapse_Homo sapiens_hsa04725	0.37468629
92	Folate biosynthesis_Homo sapiens_hsa00790	0.35479433
93	Notch signaling pathway_Homo sapiens_hsa04330	0.32534142
94	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.32303156
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.31305222
96	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.28791087
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.27219973
98	Dopaminergic synapse_Homo sapiens_hsa04728	0.25388701
99	Regulation of autophagy_Homo sapiens_hsa04140	0.25068210
100	Antigen processing and presentation_Homo sapiens_hsa04612	0.24844491

RPS24P13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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