RPS24P16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.12764438
2ribosomal small subunit biogenesis (GO:0042274)8.10190748
3ribosomal small subunit assembly (GO:0000028)7.87770326
4translational termination (GO:0006415)7.69972612
5maturation of SSU-rRNA (GO:0030490)7.21552899
6protein neddylation (GO:0045116)6.59924386
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.49297998
8cotranslational protein targeting to membrane (GO:0006613)6.45126900
9protein targeting to ER (GO:0045047)6.42656086
10translational elongation (GO:0006414)6.37235591
11establishment of protein localization to endoplasmic reticulum (GO:0072599)6.19209035
12protein localization to endoplasmic reticulum (GO:0070972)5.97677853
13cellular protein complex disassembly (GO:0043624)5.85544899
14viral life cycle (GO:0019058)5.74579802
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.72483074
16behavioral response to nicotine (GO:0035095)5.64677183
17chaperone-mediated protein transport (GO:0072321)5.20637516
18protein complex disassembly (GO:0043241)4.99272761
19translational initiation (GO:0006413)4.94132587
20macromolecular complex disassembly (GO:0032984)4.72285872
21energy coupled proton transport, down electrochemical gradient (GO:0015985)4.65374252
22ATP synthesis coupled proton transport (GO:0015986)4.65374252
23pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.44811431
24protein targeting to membrane (GO:0006612)4.40962885
25cell proliferation in forebrain (GO:0021846)4.23313392
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.10184782
27substrate-independent telencephalic tangential migration (GO:0021826)4.09877501
28substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.09877501
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.05122386
30nuclear-transcribed mRNA catabolic process (GO:0000956)4.05096376
31GTP biosynthetic process (GO:0006183)3.96362132
32ribosomal large subunit biogenesis (GO:0042273)3.92894008
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.91625854
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.91625854
35NADH dehydrogenase complex assembly (GO:0010257)3.91625854
36pyrimidine nucleotide catabolic process (GO:0006244)3.85879291
37nonmotile primary cilium assembly (GO:0035058)3.83848933
38mRNA catabolic process (GO:0006402)3.81159299
39translation (GO:0006412)3.71442918
40protein complex biogenesis (GO:0070271)3.70066661
41segment specification (GO:0007379)3.69830600
42ribonucleoprotein complex biogenesis (GO:0022613)3.62610850
43cellular component biogenesis (GO:0044085)3.47205988
44response to redox state (GO:0051775)3.46985420
45UTP biosynthetic process (GO:0006228)3.42108771
46RNA catabolic process (GO:0006401)3.39561854
47base-excision repair, AP site formation (GO:0006285)3.36206541
48establishment of protein localization to mitochondrial membrane (GO:0090151)3.34514849
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.31996611
50ncRNA 3-end processing (GO:0043628)3.28686688
51regulation of microtubule-based movement (GO:0060632)3.26314753
52respiratory electron transport chain (GO:0022904)3.23212565
53electron transport chain (GO:0022900)3.21380100
54mitochondrial respiratory chain complex assembly (GO:0033108)3.20973434
55protein polyglutamylation (GO:0018095)3.14403818
56UTP metabolic process (GO:0046051)3.10588263
57epithelial cilium movement (GO:0003351)3.04126888
58establishment of protein localization to membrane (GO:0090150)3.01625190
59tongue development (GO:0043586)3.01511322
60retinal ganglion cell axon guidance (GO:0031290)3.00509849
61regulation of cilium movement (GO:0003352)2.98544309
62dendritic spine morphogenesis (GO:0060997)2.96818521
63somite development (GO:0061053)2.96657078
64axoneme assembly (GO:0035082)2.96644314
65aldehyde catabolic process (GO:0046185)2.88835906
66axonal fasciculation (GO:0007413)2.87020888
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.86984247
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.86984247
69protein targeting (GO:0006605)2.86265825
70purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.79980178
71hydrogen ion transmembrane transport (GO:1902600)2.78365857
72cilium movement (GO:0003341)2.77784585
73axonemal dynein complex assembly (GO:0070286)2.77508891
74DNA methylation involved in gamete generation (GO:0043046)2.76807386
75positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.72915399
76purine nucleoside triphosphate biosynthetic process (GO:0009145)2.72366771
77pyrimidine nucleobase catabolic process (GO:0006208)2.71626739
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.69136836
79photoreceptor cell maintenance (GO:0045494)2.68002542
80positive regulation of respiratory burst (GO:0060267)2.67389318
81limb development (GO:0060173)2.66598876
82appendage development (GO:0048736)2.66598876
83short-term memory (GO:0007614)2.65284754
84establishment of mitochondrion localization (GO:0051654)2.63848661
85hypothalamus development (GO:0021854)2.63004396
86establishment of protein localization to organelle (GO:0072594)2.62476454
87cerebral cortex radially oriented cell migration (GO:0021799)2.55451257
88dentate gyrus development (GO:0021542)2.51146612
89synaptic transmission, cholinergic (GO:0007271)2.50369174
90negative regulation of telomere maintenance (GO:0032205)2.49540465
91mitochondrion transport along microtubule (GO:0047497)2.49210949
92establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.49210949
93negative regulation of transcription regulatory region DNA binding (GO:2000678)2.48896165
94negative regulation of appetite (GO:0032099)2.47489385
95negative regulation of response to food (GO:0032096)2.47489385
96body morphogenesis (GO:0010171)2.47226568
97RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.46433612
98positive regulation of T cell apoptotic process (GO:0070234)2.46018111
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.46012835
100cardiovascular system development (GO:0072358)2.45860677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.65619096
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.02332493
3ZNF274_21170338_ChIP-Seq_K562_Hela2.82138847
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.77666145
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.77097214
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.72103741
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.44293172
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.34387520
9IRF1_19129219_ChIP-ChIP_H3396_Human2.24253784
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10191272
11VDR_22108803_ChIP-Seq_LS180_Human2.07683814
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06599856
13ETS1_20019798_ChIP-Seq_JURKAT_Human1.99855541
14EZH2_27304074_Chip-Seq_ESCs_Mouse1.99692310
15JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88120764
16MYC_18940864_ChIP-ChIP_HL60_Human1.85866303
17CBX2_27304074_Chip-Seq_ESCs_Mouse1.83013696
18EZH2_27294783_Chip-Seq_ESCs_Mouse1.72549845
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.68627976
20REST_21632747_ChIP-Seq_MESCs_Mouse1.64911987
21TTF2_22483619_ChIP-Seq_HELA_Human1.61896365
22CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.61836187
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60475770
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.57233096
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56016319
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54694857
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48668787
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47805645
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47545460
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47064695
31TP53_22573176_ChIP-Seq_HFKS_Human1.46338857
32MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44741520
33RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.41836235
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40077977
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.39498614
36ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39078602
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37846931
38SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.36557613
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36073568
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32712356
41CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.32147310
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.30001837
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29788625
44NANOG_20526341_ChIP-Seq_ESCs_Human1.27920256
45KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27656028
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27379208
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24813635
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24813635
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19632910
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19576829
51XRN2_22483619_ChIP-Seq_HELA_Human1.19322723
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.19125516
53ERA_21632823_ChIP-Seq_H3396_Human1.17154003
54TAF2_19829295_ChIP-Seq_ESCs_Human1.16459171
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15501679
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15346796
57FOXP3_21729870_ChIP-Seq_TREG_Human1.13656616
58P300_19829295_ChIP-Seq_ESCs_Human1.12106081
59CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11652970
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10493878
61GATA1_26923725_Chip-Seq_HPCs_Mouse1.10224592
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09187080
63RNF2_27304074_Chip-Seq_NSC_Mouse1.08162573
64NCOR_22424771_ChIP-Seq_293T_Human1.07740307
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07062249
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06135445
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05580782
68SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05127511
69EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04989080
70TP53_20018659_ChIP-ChIP_R1E_Mouse1.02117072
71GABP_19822575_ChIP-Seq_HepG2_Human1.01707465
72CTCF_27219007_Chip-Seq_Bcells_Human1.00844962
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.00423002
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.00157338
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00157338
76SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99203726
77CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98975625
78VDR_23849224_ChIP-Seq_CD4+_Human0.98708046
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98200552
80NOTCH1_21737748_ChIP-Seq_TLL_Human0.98133116
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97785717
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97785717
83RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96528087
84P53_21459846_ChIP-Seq_SAOS-2_Human0.94926147
85EWS_26573619_Chip-Seq_HEK293_Human0.93961020
86MYC_19829295_ChIP-Seq_ESCs_Human0.92748267
87HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92565002
88IGF1R_20145208_ChIP-Seq_DFB_Human0.92498442
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91142167
90MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90778791
91MYC_18358816_ChIP-ChIP_MESCs_Mouse0.90200631
92FUS_26573619_Chip-Seq_HEK293_Human0.89506755
93OCT4_19829295_ChIP-Seq_ESCs_Human0.89287389
94CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88683897
95PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88534710
96CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88431647
97YY1_22570637_ChIP-Seq_MALME-3M_Human0.88401487
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86002448
99RING1B_27294783_Chip-Seq_ESCs_Mouse0.85736638
100TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84422228

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.00771481
2MP0006292_abnormal_olfactory_placode5.00669936
3MP0002102_abnormal_ear_morphology3.86356960
4MP0002653_abnormal_ependyma_morphology3.44686720
5MP0003787_abnormal_imprinting3.42295199
6MP0003122_maternal_imprinting2.85823109
7MP0001348_abnormal_lacrimal_gland2.74894854
8MP0008877_abnormal_DNA_methylation2.67304376
9MP0008789_abnormal_olfactory_epithelium2.45157030
10MP0005499_abnormal_olfactory_system2.43988105
11MP0005394_taste/olfaction_phenotype2.43988105
12MP0003646_muscle_fatigue2.31272290
13MP0001293_anophthalmia2.17108291
14MP0003121_genomic_imprinting2.13846902
15MP0003890_abnormal_embryonic-extraembry2.10961782
16MP0003878_abnormal_ear_physiology2.09171911
17MP0005377_hearing/vestibular/ear_phenot2.09171911
18MP0003123_paternal_imprinting2.08610528
19MP0004142_abnormal_muscle_tone2.01432462
20MP0004742_abnormal_vestibular_system2.01361968
21MP0001529_abnormal_vocalization1.95284676
22MP0000778_abnormal_nervous_system1.90154076
23MP0001984_abnormal_olfaction1.84287662
24MP0001485_abnormal_pinna_reflex1.83963748
25MP0006276_abnormal_autonomic_nervous1.79834576
26MP0000049_abnormal_middle_ear1.79660507
27MP0008872_abnormal_physiological_respon1.64060090
28MP0010030_abnormal_orbit_morphology1.54826985
29MP0002938_white_spotting1.49775668
30MP0000566_synostosis1.45218165
31MP0001440_abnormal_grooming_behavior1.44517322
32MP0002557_abnormal_social/conspecific_i1.43949344
33MP0004885_abnormal_endolymph1.43014539
34MP0002736_abnormal_nociception_after1.42725737
35MP0005551_abnormal_eye_electrophysiolog1.40145789
36MP0001968_abnormal_touch/_nociception1.36242732
37MP0002837_dystrophic_cardiac_calcinosis1.29120042
38MP0003635_abnormal_synaptic_transmissio1.29009099
39MP0004133_heterotaxia1.28956976
40MP0002272_abnormal_nervous_system1.28670135
41MP0001970_abnormal_pain_threshold1.28166204
42MP0002572_abnormal_emotion/affect_behav1.27724216
43MP0000631_abnormal_neuroendocrine_gland1.24745693
44MP0000955_abnormal_spinal_cord1.24360397
45MP0002184_abnormal_innervation1.23922190
46MP0002063_abnormal_learning/memory/cond1.22462229
47MP0008875_abnormal_xenobiotic_pharmacok1.21509701
48MP0006072_abnormal_retinal_apoptosis1.19230555
49MP0003186_abnormal_redox_activity1.17626612
50MP0002752_abnormal_somatic_nervous1.14011705
51MP0002876_abnormal_thyroid_physiology1.12457682
52MP0003011_delayed_dark_adaptation1.12212245
53MP0001919_abnormal_reproductive_system1.11918344
54MP0001486_abnormal_startle_reflex1.11705015
55MP0003136_yellow_coat_color1.11391445
56MP0000026_abnormal_inner_ear1.09731002
57MP0009745_abnormal_behavioral_response1.08868876
58MP0005084_abnormal_gallbladder_morpholo1.06869811
59MP0004145_abnormal_muscle_electrophysio1.06055748
60MP0004924_abnormal_behavior1.05635520
61MP0005386_behavior/neurological_phenoty1.05635520
62MP0005195_abnormal_posterior_eye1.05365559
63MP0005389_reproductive_system_phenotype1.05058131
64MP0003880_abnormal_central_pattern1.04639003
65MP0005253_abnormal_eye_physiology1.02134013
66MP0002734_abnormal_mechanical_nocicepti1.00401436
67MP0002733_abnormal_thermal_nociception0.98686513
68MP0005645_abnormal_hypothalamus_physiol0.96130153
69MP0001188_hyperpigmentation0.96092840
70MP0005379_endocrine/exocrine_gland_phen0.95889154
71MP0009046_muscle_twitch0.93927248
72MP0005423_abnormal_somatic_nervous0.92785978
73MP0003937_abnormal_limbs/digits/tail_de0.92378786
74MP0002638_abnormal_pupillary_reflex0.91866547
75MP0004130_abnormal_muscle_cell0.90738617
76MP0002882_abnormal_neuron_morphology0.88924207
77MP0000427_abnormal_hair_cycle0.87990540
78MP0003119_abnormal_digestive_system0.87766224
79MP0002735_abnormal_chemical_nociception0.85822731
80MP0002152_abnormal_brain_morphology0.82323015
81MP0005391_vision/eye_phenotype0.82290717
82MP0001905_abnormal_dopamine_level0.82261944
83MP0001502_abnormal_circadian_rhythm0.80099664
84MP0003942_abnormal_urinary_system0.79902968
85MP0002928_abnormal_bile_duct0.79621578
86MP0003861_abnormal_nervous_system0.79419966
87MP0002160_abnormal_reproductive_system0.79199717
88MP0002067_abnormal_sensory_capabilities0.78620928
89MP0002822_catalepsy0.77317780
90MP0002210_abnormal_sex_determination0.76663093
91MP0001286_abnormal_eye_development0.76640365
92MP0002233_abnormal_nose_morphology0.74822948
93MP0002095_abnormal_skin_pigmentation0.74309616
94MP0003567_abnormal_fetal_cardiomyocyte0.73047642
95MP0002064_seizures0.69687903
96MP0000428_abnormal_craniofacial_morphol0.69487917
97MP0003938_abnormal_ear_development0.69442488
98MP0001963_abnormal_hearing_physiology0.68363519
99MP0004859_abnormal_synaptic_plasticity0.68130216
100MP0002234_abnormal_pharynx_morphology0.67913085

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.49044938
2Abnormality of midbrain morphology (HP:0002418)4.70687757
3Molar tooth sign on MRI (HP:0002419)4.70687757
4Abnormality of cells of the erythroid lineage (HP:0012130)4.50721438
5Pancreatic fibrosis (HP:0100732)3.97712930
6Acute necrotizing encephalopathy (HP:0006965)3.67630733
7Macrocytic anemia (HP:0001972)3.60056867
8Absent rod-and cone-mediated responses on ERG (HP:0007688)3.55058381
9Abnormal number of erythroid precursors (HP:0012131)3.42035285
10Acute encephalopathy (HP:0006846)3.30551651
11Abnormal mitochondria in muscle tissue (HP:0008316)3.30411344
12Pancreatic cysts (HP:0001737)3.23056245
13Nephronophthisis (HP:0000090)3.08629621
14Aplasia/Hypoplasia of the sacrum (HP:0008517)3.06627353
15Mitochondrial inheritance (HP:0001427)3.05244956
16Pallor (HP:0000980)3.00588579
17Progressive macrocephaly (HP:0004481)2.89098441
18Pendular nystagmus (HP:0012043)2.80253201
19Rib fusion (HP:0000902)2.77113211
20Increased hepatocellular lipid droplets (HP:0006565)2.75259115
21Increased CSF lactate (HP:0002490)2.73226143
22Cystic liver disease (HP:0006706)2.70524316
23Medial flaring of the eyebrow (HP:0010747)2.68720442
24Absent thumb (HP:0009777)2.67190090
25Sclerocornea (HP:0000647)2.66865702
26Deep palmar crease (HP:0006191)2.65365835
27Abnormal rod and cone electroretinograms (HP:0008323)2.63146053
28True hermaphroditism (HP:0010459)2.62085146
29Myokymia (HP:0002411)2.61970132
30Abnormality of the labia minora (HP:0012880)2.60979953
31Pachygyria (HP:0001302)2.59179783
32Septo-optic dysplasia (HP:0100842)2.57547992
33Colon cancer (HP:0003003)2.55942016
34Optic disc pallor (HP:0000543)2.55591349
35Abnormal hemoglobin (HP:0011902)2.51980534
36Lipid accumulation in hepatocytes (HP:0006561)2.51870643
37Agitation (HP:0000713)2.47432301
38Type II lissencephaly (HP:0007260)2.46761773
39Anencephaly (HP:0002323)2.46757396
403-Methylglutaconic aciduria (HP:0003535)2.43035565
41Abnormality of the renal medulla (HP:0100957)2.37588403
42Aplasia/Hypoplasia of the spleen (HP:0010451)2.33650810
43Polyphagia (HP:0002591)2.32520407
44Hepatocellular necrosis (HP:0001404)2.30403833
45Gait imbalance (HP:0002141)2.24977578
46Stenosis of the external auditory canal (HP:0000402)2.24617398
47Bifid tongue (HP:0010297)2.22999929
48Adrenal hypoplasia (HP:0000835)2.20284997
49Asplenia (HP:0001746)2.18481810
50Anophthalmia (HP:0000528)2.18156521
51Depressed nasal ridge (HP:0000457)2.17110751
52Cerebellar dysplasia (HP:0007033)2.16928576
53Abnormal ciliary motility (HP:0012262)2.13249136
54Abnormality of reticulocytes (HP:0004312)2.11963312
55Postaxial foot polydactyly (HP:0001830)2.08952647
56Hepatic necrosis (HP:0002605)2.08479805
57Lissencephaly (HP:0001339)2.05359689
58Cerebral edema (HP:0002181)2.02783200
59Tubulointerstitial nephritis (HP:0001970)2.01017306
60Abnormal respiratory motile cilium physiology (HP:0012261)1.99993502
61Abnormality of the aortic arch (HP:0012303)1.96964077
62Aplasia/Hypoplasia of the brainstem (HP:0007362)1.96733866
63Hypoplasia of the brainstem (HP:0002365)1.96733866
64Porencephaly (HP:0002132)1.96214561
65Congenital hepatic fibrosis (HP:0002612)1.93812652
66Congenital primary aphakia (HP:0007707)1.92905739
67Congenital stationary night blindness (HP:0007642)1.91945601
68Median cleft lip (HP:0000161)1.91693508
69Tubular atrophy (HP:0000092)1.91000709
70Increased intramyocellular lipid droplets (HP:0012240)1.90310659
71Horseshoe kidney (HP:0000085)1.89868621
72Partial duplication of thumb phalanx (HP:0009944)1.88785650
73Abnormal respiratory motile cilium morphology (HP:0005938)1.87938004
74Abnormal respiratory epithelium morphology (HP:0012253)1.87938004
75Ectopic kidney (HP:0000086)1.85862173
76Genital tract atresia (HP:0001827)1.85773001
77Triphalangeal thumb (HP:0001199)1.84957191
78Narrow forehead (HP:0000341)1.83895864
79Abnormal drinking behavior (HP:0030082)1.81956071
80Polydipsia (HP:0001959)1.81956071
81Anterior segment dysgenesis (HP:0007700)1.80979010
82Abolished electroretinogram (ERG) (HP:0000550)1.79750569
83Renal Fanconi syndrome (HP:0001994)1.79298179
84Preaxial hand polydactyly (HP:0001177)1.78208113
85Tachypnea (HP:0002789)1.78099846
86Vaginal atresia (HP:0000148)1.77354485
87Abnormality of the diencephalon (HP:0010662)1.77137369
88Supernumerary spleens (HP:0009799)1.75856656
89Impulsivity (HP:0100710)1.75608859
90Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.74232708
91Hypoplasia of the radius (HP:0002984)1.73998015
92Lactic acidosis (HP:0003128)1.73682160
93Increased serum lactate (HP:0002151)1.72874098
94Hyperglycinemia (HP:0002154)1.71947332
95Oligodactyly (hands) (HP:0001180)1.71558641
96Small hand (HP:0200055)1.70207774
97Aplasia/Hypoplasia of the tongue (HP:0010295)1.69516674
98Dandy-Walker malformation (HP:0001305)1.68642851
99Holoprosencephaly (HP:0001360)1.67624245
100Nephrogenic diabetes insipidus (HP:0009806)1.67111563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK43.36590491
2NUAK13.14755482
3SIK23.04321324
4STK162.96128808
5WNK32.85890058
6CDK192.69381798
7EPHB22.52024749
8DYRK22.35904085
9TNIK2.23010141
10PINK12.22199289
11MARK12.12776691
12ADRBK22.01083668
13NEK21.91464877
14GRK11.77853356
15BCKDK1.75086765
16CASK1.66059457
17EPHA41.64386454
18MAP4K21.62833023
19NME21.61465967
20FRK1.57920488
21PIK3CA1.55944754
22TLK11.50502176
23NME11.49709890
24NTRK21.37914963
25LRRK21.35036222
26MAP3K111.33412513
27LATS11.31826597
28BRD41.30549035
29ZAK1.27502785
30ICK1.25684119
31STK391.22507339
32PRKCG1.19316895
33CAMKK21.16329429
34DYRK31.13711804
35CAMK1D1.12909509
36MAP2K71.12024230
37BRSK11.04292296
38NEK11.03744483
39CAMK10.99365452
40ADRBK10.98949222
41MINK10.98629044
42TIE10.94817793
43PDK20.91760354
44STK110.91397415
45TAOK30.89365128
46TYRO30.88339120
47BMPR1B0.88064691
48PRKCQ0.85545948
49SGK2230.82132283
50SGK4940.82132283
51CAMKK10.78822790
52PAK30.77883450
53CDC70.76553795
54ABL20.75361144
55MAP2K20.74991161
56MAPK130.74325769
57WNK10.73757698
58BRAF0.73392054
59CAMK1G0.73160899
60AURKA0.72852875
61SGK20.71876291
62PBK0.71875205
63PHKG10.71198668
64PHKG20.71198668
65DAPK30.68573223
66PRKACA0.67522518
67DAPK20.65263744
68CSNK1E0.63402332
69MAP3K90.62901999
70INSRR0.62191592
71TXK0.61081580
72PLK10.59214705
73LIMK10.56617409
74DYRK1A0.55657741
75CSNK2A20.53344998
76CHEK20.52668137
77PRKCZ0.52051092
78MAP3K40.51792046
79RPS6KA60.50672322
80ACVR1B0.50014504
81STK30.49415595
82NTRK10.48797795
83MARK20.48781644
84GRK70.48224812
85MKNK20.48020361
86RPS6KA50.44686279
87ATR0.43578163
88CAMK40.42887247
89PRKCD0.41818101
90OXSR10.41321623
91DMPK0.40706760
92CSNK2A10.39623782
93PRKG10.39235289
94MATK0.39209844
95OBSCN0.37715107
96CAMK2A0.37323201
97PAK60.36761022
98PRKACG0.36670980
99PRKDC0.35823961
100PRKCA0.35356043

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.77126520
2Oxidative phosphorylation_Homo sapiens_hsa001904.11929899
3Parkinsons disease_Homo sapiens_hsa050123.50243747
4Cardiac muscle contraction_Homo sapiens_hsa042602.87124622
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.83251115
6Huntingtons disease_Homo sapiens_hsa050162.65233623
7RNA polymerase_Homo sapiens_hsa030202.49248120
8Alzheimers disease_Homo sapiens_hsa050102.47639517
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.28877849
10Sulfur relay system_Homo sapiens_hsa041222.14623174
11Linoleic acid metabolism_Homo sapiens_hsa005912.05182933
12Nicotine addiction_Homo sapiens_hsa050332.01603954
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.99935976
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94959663
15Phototransduction_Homo sapiens_hsa047441.86645509
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59208673
17RNA degradation_Homo sapiens_hsa030181.57062439
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46067600
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33254440
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32135213
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30615403
22Butanoate metabolism_Homo sapiens_hsa006501.25666183
23Basal transcription factors_Homo sapiens_hsa030221.25613613
24Protein export_Homo sapiens_hsa030601.23003994
25Mismatch repair_Homo sapiens_hsa034301.13135921
26Folate biosynthesis_Homo sapiens_hsa007901.12328342
27Pyrimidine metabolism_Homo sapiens_hsa002401.09151861
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06854486
29Tryptophan metabolism_Homo sapiens_hsa003801.06789615
30Olfactory transduction_Homo sapiens_hsa047401.02655679
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02478058
32Fanconi anemia pathway_Homo sapiens_hsa034601.01210194
33Homologous recombination_Homo sapiens_hsa034400.98993364
34Ether lipid metabolism_Homo sapiens_hsa005650.98273041
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98126297
36Morphine addiction_Homo sapiens_hsa050320.97151295
37Fat digestion and absorption_Homo sapiens_hsa049750.97035252
38Propanoate metabolism_Homo sapiens_hsa006400.96773816
39Taste transduction_Homo sapiens_hsa047420.93686772
40beta-Alanine metabolism_Homo sapiens_hsa004100.91148681
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87216572
42Peroxisome_Homo sapiens_hsa041460.83873863
43Asthma_Homo sapiens_hsa053100.81753806
44Chemical carcinogenesis_Homo sapiens_hsa052040.80783045
45Steroid biosynthesis_Homo sapiens_hsa001000.80579087
46Insulin secretion_Homo sapiens_hsa049110.77967067
47Nitrogen metabolism_Homo sapiens_hsa009100.77751433
48Serotonergic synapse_Homo sapiens_hsa047260.77663476
49Glycerolipid metabolism_Homo sapiens_hsa005610.77621523
50Basal cell carcinoma_Homo sapiens_hsa052170.76859587
51Axon guidance_Homo sapiens_hsa043600.76198389
52Ovarian steroidogenesis_Homo sapiens_hsa049130.74233905
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74175957
54Fatty acid degradation_Homo sapiens_hsa000710.74123802
55Hedgehog signaling pathway_Homo sapiens_hsa043400.73951536
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73416414
57Retinol metabolism_Homo sapiens_hsa008300.70468748
58Glutamatergic synapse_Homo sapiens_hsa047240.70096077
59Arachidonic acid metabolism_Homo sapiens_hsa005900.68995866
60Metabolic pathways_Homo sapiens_hsa011000.68807567
61Purine metabolism_Homo sapiens_hsa002300.68034403
62Nucleotide excision repair_Homo sapiens_hsa034200.67472942
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66697176
64Arginine and proline metabolism_Homo sapiens_hsa003300.64840104
65Notch signaling pathway_Homo sapiens_hsa043300.64312046
66Caffeine metabolism_Homo sapiens_hsa002320.63053268
67RNA transport_Homo sapiens_hsa030130.62138701
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.59100214
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58916847
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58187146
71GABAergic synapse_Homo sapiens_hsa047270.57109825
72Proteasome_Homo sapiens_hsa030500.55431269
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53278262
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48137072
75DNA replication_Homo sapiens_hsa030300.48014765
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.47157789
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46976834
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44019357
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.43856366
80Base excision repair_Homo sapiens_hsa034100.43436193
81Pyruvate metabolism_Homo sapiens_hsa006200.41440355
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38489880
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.35656324
84Collecting duct acid secretion_Homo sapiens_hsa049660.34107259
85Cholinergic synapse_Homo sapiens_hsa047250.33848431
86Starch and sucrose metabolism_Homo sapiens_hsa005000.33363713
87p53 signaling pathway_Homo sapiens_hsa041150.33225059
88Mineral absorption_Homo sapiens_hsa049780.32208654
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31579860
90Hippo signaling pathway_Homo sapiens_hsa043900.31468679
91Spliceosome_Homo sapiens_hsa030400.29749817
92Vitamin B6 metabolism_Homo sapiens_hsa007500.29704144
93Salivary secretion_Homo sapiens_hsa049700.29301570
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27031049
95Cocaine addiction_Homo sapiens_hsa050300.26018888
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25542568
97Synaptic vesicle cycle_Homo sapiens_hsa047210.24988017
98Circadian entrainment_Homo sapiens_hsa047130.24827090
99Dopaminergic synapse_Homo sapiens_hsa047280.24560604
100Alcoholism_Homo sapiens_hsa050340.24486408

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