ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maturation of SSU-rRNA (GO:0030490)	9.40559139
2	viral transcription (GO:0019083)	8.97543426
3	ribosomal small subunit biogenesis (GO:0042274)	8.93390197
4	translational termination (GO:0006415)	8.54920266
5	ribosomal small subunit assembly (GO:0000028)	7.88584296
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.21133261
7	cotranslational protein targeting to membrane (GO:0006613)	7.15379120
8	protein targeting to ER (GO:0045047)	7.09254663
9	translational elongation (GO:0006414)	7.04561489
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.80030557
11	protein localization to endoplasmic reticulum (GO:0070972)	6.66201426
12	viral life cycle (GO:0019058)	6.64802276
13	cellular protein complex disassembly (GO:0043624)	6.54070168
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.27242341
15	ATP synthesis coupled proton transport (GO:0015986)	6.09420654
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.09420654
17	protein complex disassembly (GO:0043241)	5.59824353
18	chaperone-mediated protein transport (GO:0072321)	5.48950102
19	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.46973382
20	translational initiation (GO:0006413)	5.46200412
21	ribosomal large subunit biogenesis (GO:0042273)	5.43591181
22	macromolecular complex disassembly (GO:0032984)	5.35023278
23	protein neddylation (GO:0045116)	5.17176590
24	protein targeting to membrane (GO:0006612)	4.87705974
25	behavioral response to nicotine (GO:0035095)	4.43731981
26	nonmotile primary cilium assembly (GO:0035058)	4.42812402
27	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.36120256
28	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.33394906
29	translation (GO:0006412)	4.23059630
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.22457806
31	NADH dehydrogenase complex assembly (GO:0010257)	4.22457806
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.22457806
33	ribonucleoprotein complex biogenesis (GO:0022613)	4.16338670
34	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.11937685
35	mRNA catabolic process (GO:0006402)	4.09264691
36	respiratory electron transport chain (GO:0022904)	4.00095160
37	electron transport chain (GO:0022900)	3.96568266
38	protein complex biogenesis (GO:0070271)	3.91950127
39	cellular component biogenesis (GO:0044085)	3.90037809
40	cell proliferation in forebrain (GO:0021846)	3.87656056
41	substrate-independent telencephalic tangential migration (GO:0021826)	3.84399858
42	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.84399858
43	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.63360639
44	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.63360639
45	body morphogenesis (GO:0010171)	3.63163633
46	RNA catabolic process (GO:0006401)	3.61133495
47	ATP biosynthetic process (GO:0006754)	3.50976070
48	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.49985079
49	axon ensheathment in central nervous system (GO:0032291)	3.44559586
50	central nervous system myelination (GO:0022010)	3.44559586
51	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.40114333
52	mitochondrial respiratory chain complex assembly (GO:0033108)	3.39651979
53	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.36294336
54	establishment of protein localization to membrane (GO:0090150)	3.33343098
55	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.30663422
56	protein targeting (GO:0006605)	3.16861718
57	pattern specification involved in kidney development (GO:0061004)	3.12907085
58	somite development (GO:0061053)	3.11276204
59	embryonic body morphogenesis (GO:0010172)	3.09755462
60	GTP biosynthetic process (GO:0006183)	3.05718832
61	positive regulation of protein homooligomerization (GO:0032464)	3.02640258
62	hydrogen ion transmembrane transport (GO:1902600)	3.01997191
63	appendage development (GO:0048736)	3.00866142
64	limb development (GO:0060173)	3.00866142
65	pyrimidine nucleotide catabolic process (GO:0006244)	2.95221878
66	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.94190237
67	cardiovascular system development (GO:0072358)	2.92111301
68	establishment of protein localization to organelle (GO:0072594)	2.91435892
69	neuron fate determination (GO:0048664)	2.83891082
70	viral protein processing (GO:0019082)	2.81776562
71	genetic imprinting (GO:0071514)	2.79300782
72	hypothalamus development (GO:0021854)	2.77848933
73	water-soluble vitamin biosynthetic process (GO:0042364)	2.76725885
74	tongue development (GO:0043586)	2.76278801
75	pyrimidine nucleobase catabolic process (GO:0006208)	2.74266164
76	protein localization to membrane (GO:0072657)	2.73612018
77	spinal cord association neuron differentiation (GO:0021527)	2.72603352
78	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.70569605
79	segment specification (GO:0007379)	2.69000219
80	UTP biosynthetic process (GO:0006228)	2.66671295
81	positive regulation of T cell apoptotic process (GO:0070234)	2.66054890
82	proton transport (GO:0015992)	2.63883780
83	nephron tubule morphogenesis (GO:0072078)	2.61746576
84	nephron epithelium morphogenesis (GO:0072088)	2.61746576
85	hydrogen transport (GO:0006818)	2.58109635
86	epithelial cilium movement (GO:0003351)	2.57556511
87	positive regulation of respiratory burst (GO:0060267)	2.55796726
88	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.55597013
89	axonal fasciculation (GO:0007413)	2.55544148
90	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.54031451
91	cell wall macromolecule metabolic process (GO:0044036)	2.53913575
92	rRNA processing (GO:0006364)	2.53579692
93	dendritic spine morphogenesis (GO:0060997)	2.53405850
94	response to redox state (GO:0051775)	2.51327218
95	UTP metabolic process (GO:0046051)	2.49273500
96	rRNA metabolic process (GO:0016072)	2.47298180
97	aldehyde catabolic process (GO:0046185)	2.46855069
98	regulation of cilium movement (GO:0003352)	2.46523219
99	head development (GO:0060322)	2.44653712
100	short-term memory (GO:0007614)	2.41102581

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.74991189
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.65565010
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.16568865
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.93076891
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.82258983
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.56970223
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.38358082
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.32650598
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.21504464
10	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.20396347
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.14536713
12	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.10271403
13	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.03849434
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.01726914
15	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.00148939
16	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.90232122
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.90097759
18	VDR_22108803_ChIP-Seq_LS180_Human	1.88546467
19	ZNF274_21170338_ChIP-Seq_K562_Hela	1.81704190
20	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.80998584
21	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.80926699
22	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.80081569
23	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.79992488
24	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.71096160
25	TTF2_22483619_ChIP-Seq_HELA_Human	1.64859638
26	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.62062886
27	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.61451365
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.57146964
29	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.56007451
30	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.53895333
31	REST_21632747_ChIP-Seq_MESCs_Mouse	1.53342745
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.53043851
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.52513716
34	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.49674944
35	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.49232794
36	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.48841251
37	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.48125037
38	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.45562441
39	XRN2_22483619_ChIP-Seq_HELA_Human	1.45068739
40	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.37509250
41	RNF2_27304074_Chip-Seq_NSC_Mouse	1.37380943
42	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.36306030
43	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.36127339
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34447174
45	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.31316715
46	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.31063970
47	GABP_19822575_ChIP-Seq_HepG2_Human	1.29723961
48	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.29269481
49	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.29269481
50	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.23644670
51	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.22387996
52	TP53_22573176_ChIP-Seq_HFKS_Human	1.21948824
53	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.21878278
54	NANOG_20526341_ChIP-Seq_ESCs_Human	1.21367056
55	FOXP3_21729870_ChIP-Seq_TREG_Human	1.21136103
56	CTCF_27219007_Chip-Seq_Bcells_Human	1.20526550
57	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.20399786
58	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.19954009
59	ERA_21632823_ChIP-Seq_H3396_Human	1.17393141
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16375061
61	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.14374378
62	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.13783651
63	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.13203838
64	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12783014
65	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.12304645
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11789671
67	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.11623699
68	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.10736361
69	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.10547408
70	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.09965543
71	NCOR_22424771_ChIP-Seq_293T_Human	1.08258317
72	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.07233240
73	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.07219636
74	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.05644684
75	VDR_23849224_ChIP-Seq_CD4+_Human	1.03784381
76	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.03120736
77	MYC_19829295_ChIP-Seq_ESCs_Human	1.02188475
78	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.01949209
79	TAF2_19829295_ChIP-Seq_ESCs_Human	1.01739472
80	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.99626765
81	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.99459361
82	ELK1_19687146_ChIP-ChIP_HELA_Human	0.98360665
83	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.97691191
84	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.97067346
85	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.96594449
86	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.96176512
87	BCL6_27268052_Chip-Seq_Bcells_Human	0.95638054
88	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.95571791
89	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.94189811
90	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.93604379
91	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.93544978
92	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.92871112
93	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.92690386
94	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.92437054
95	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.92331627
96	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.92315965
97	CTCF_20526341_ChIP-Seq_ESCs_Human	0.92059201
98	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.91326697
99	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.91052200
100	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.90461943

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.33483211
2	MP0006292_abnormal_olfactory_placode	4.88047867
3	MP0003787_abnormal_imprinting	3.57402658
4	MP0003878_abnormal_ear_physiology	2.82021041
5	MP0005377_hearing/vestibular/ear_phenot	2.82021041
6	MP0008789_abnormal_olfactory_epithelium	2.72529560
7	MP0002653_abnormal_ependyma_morphology	2.71578941
8	MP0003122_maternal_imprinting	2.67324744
9	MP0003123_paternal_imprinting	2.51767388
10	MP0004142_abnormal_muscle_tone	2.48729867
11	MP0005394_taste/olfaction_phenotype	2.38775803
12	MP0005499_abnormal_olfactory_system	2.38775803
13	MP0001293_anophthalmia	2.14154633
14	MP0002163_abnormal_gland_morphology	2.06092848
15	MP0003880_abnormal_central_pattern	2.04811757
16	MP0003646_muscle_fatigue	2.00742252
17	MP0006276_abnormal_autonomic_nervous	1.96634503
18	MP0003121_genomic_imprinting	1.92872680
19	MP0008877_abnormal_DNA_methylation	1.92391040
20	MP0000778_abnormal_nervous_system	1.85752275
21	MP0010030_abnormal_orbit_morphology	1.81614096
22	MP0004885_abnormal_endolymph	1.77866110
23	MP0001529_abnormal_vocalization	1.69965516
24	MP0003136_yellow_coat_color	1.65374218
25	MP0005646_abnormal_pituitary_gland	1.61448258
26	MP0001485_abnormal_pinna_reflex	1.57060678
27	MP0002095_abnormal_skin_pigmentation	1.47742737
28	MP0000631_abnormal_neuroendocrine_gland	1.47050492
29	MP0000049_abnormal_middle_ear	1.46841268
30	MP0003879_abnormal_hair_cell	1.43459482
31	MP0003186_abnormal_redox_activity	1.39487238
32	MP0005551_abnormal_eye_electrophysiolog	1.38671138
33	MP0002557_abnormal_social/conspecific_i	1.37655979
34	MP0004147_increased_porphyrin_level	1.36487521
35	MP0001440_abnormal_grooming_behavior	1.36070709
36	MP0002938_white_spotting	1.34579151
37	MP0001968_abnormal_touch/_nociception	1.34234414
38	MP0002272_abnormal_nervous_system	1.32160040
39	MP0004742_abnormal_vestibular_system	1.30924094
40	MP0001905_abnormal_dopamine_level	1.29564484
41	MP0005195_abnormal_posterior_eye	1.26273904
42	MP0005645_abnormal_hypothalamus_physiol	1.24284282
43	MP0008872_abnormal_physiological_respon	1.24017496
44	MP0005379_endocrine/exocrine_gland_phen	1.20594380
45	MP0000955_abnormal_spinal_cord	1.20430298
46	MP0001986_abnormal_taste_sensitivity	1.13433070
47	MP0002102_abnormal_ear_morphology	1.13278559
48	MP0002160_abnormal_reproductive_system	1.12335272
49	MP0002752_abnormal_somatic_nervous	1.12258060
50	MP0004133_heterotaxia	1.11932524
51	MP0005423_abnormal_somatic_nervous	1.09176409
52	MP0002736_abnormal_nociception_after	1.09052703
53	MP0005389_reproductive_system_phenotype	1.08345040
54	MP0009745_abnormal_behavioral_response	1.07087672
55	MP0000015_abnormal_ear_pigmentation	1.07043457
56	MP0008875_abnormal_xenobiotic_pharmacok	1.06683721
57	MP0001919_abnormal_reproductive_system	1.06048659
58	MP0000026_abnormal_inner_ear	1.04089184
59	MP0002734_abnormal_mechanical_nocicepti	1.03208002
60	MP0002184_abnormal_innervation	1.02512410
61	MP0001286_abnormal_eye_development	1.00482536
62	MP0009046_muscle_twitch	0.99415769
63	MP0002638_abnormal_pupillary_reflex	0.99030557
64	MP0001970_abnormal_pain_threshold	0.98523106
65	MP0001984_abnormal_olfaction	0.95800729
66	MP0004145_abnormal_muscle_electrophysio	0.93871580
67	MP0002876_abnormal_thyroid_physiology	0.92931405
68	MP0003635_abnormal_synaptic_transmissio	0.92771133
69	MP0002233_abnormal_nose_morphology	0.91127710
70	MP0002837_dystrophic_cardiac_calcinosis	0.90172403
71	MP0001486_abnormal_startle_reflex	0.89291720
72	MP0002882_abnormal_neuron_morphology	0.88928864
73	MP0002572_abnormal_emotion/affect_behav	0.88359335
74	MP0002138_abnormal_hepatobiliary_system	0.86537391
75	MP0001324_abnormal_eye_pigmentation	0.85609176
76	MP0004043_abnormal_pH_regulation	0.85563369
77	MP0002733_abnormal_thermal_nociception	0.84419809
78	MP0002063_abnormal_learning/memory/cond	0.84170974
79	MP0001963_abnormal_hearing_physiology	0.83729201
80	MP0001663_abnormal_digestive_system	0.83723386
81	MP0005083_abnormal_biliary_tract	0.82977078
82	MP0001348_abnormal_lacrimal_gland	0.82601753
83	MP0003011_delayed_dark_adaptation	0.82033514
84	MP0002152_abnormal_brain_morphology	0.81714155
85	MP0003942_abnormal_urinary_system	0.80214766
86	MP0002210_abnormal_sex_determination	0.80045406
87	MP0003937_abnormal_limbs/digits/tail_de	0.79989640
88	MP0003938_abnormal_ear_development	0.77372898
89	MP0002067_abnormal_sensory_capabilities	0.77103196
90	MP0005084_abnormal_gallbladder_morpholo	0.76111210
91	MP0006072_abnormal_retinal_apoptosis	0.74878531
92	MP0001502_abnormal_circadian_rhythm	0.74668746
93	MP0002234_abnormal_pharynx_morphology	0.73294166
94	MP0008775_abnormal_heart_ventricle	0.72728127
95	MP0003861_abnormal_nervous_system	0.71527334
96	MP0004130_abnormal_muscle_cell	0.71366620
97	MP0005174_abnormal_tail_pigmentation	0.70644887
98	MP0002064_seizures	0.69681191
99	MP0004924_abnormal_behavior	0.67717508
100	MP0005386_behavior/neurological_phenoty	0.67717508

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.69334455
2	Abnormality of cells of the erythroid lineage (HP:0012130)	5.16639385
3	Abnormal hemoglobin (HP:0011902)	4.71946851
4	Acute necrotizing encephalopathy (HP:0006965)	4.53207576
5	Aplasia/Hypoplasia of the sacrum (HP:0008517)	4.24471146
6	Macrocytic anemia (HP:0001972)	4.24308955
7	Pallor (HP:0000980)	4.20270245
8	Abnormal mitochondria in muscle tissue (HP:0008316)	4.12412015
9	Acute encephalopathy (HP:0006846)	4.01097309
10	Molar tooth sign on MRI (HP:0002419)	3.73825254
11	Abnormality of midbrain morphology (HP:0002418)	3.73825254
12	Progressive macrocephaly (HP:0004481)	3.55571727
13	Mitochondrial inheritance (HP:0001427)	3.48180664
14	Abnormal number of erythroid precursors (HP:0012131)	3.45359616
15	Pancreatic fibrosis (HP:0100732)	3.35986698
16	Nephronophthisis (HP:0000090)	3.14155156
17	Increased CSF lactate (HP:0002490)	3.12130092
18	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.09411564
19	Septo-optic dysplasia (HP:0100842)	2.98075720
20	Abnormality of alanine metabolism (HP:0010916)	2.97623839
21	Hyperalaninemia (HP:0003348)	2.97623839
22	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.97623839
23	Cerebral edema (HP:0002181)	2.93546758
24	3-Methylglutaconic aciduria (HP:0003535)	2.91850556
25	Hepatocellular necrosis (HP:0001404)	2.86506409
26	Pancreatic cysts (HP:0001737)	2.83437623
27	Medial flaring of the eyebrow (HP:0010747)	2.80598255
28	Rib fusion (HP:0000902)	2.74899492
29	Absent thumb (HP:0009777)	2.74308680
30	Anophthalmia (HP:0000528)	2.70274481
31	Optic disc pallor (HP:0000543)	2.70106164
32	Hyperthyroidism (HP:0000836)	2.69280754
33	Myokymia (HP:0002411)	2.66222033
34	Stenosis of the external auditory canal (HP:0000402)	2.61400035
35	Colon cancer (HP:0003003)	2.57874932
36	Pendular nystagmus (HP:0012043)	2.52491457
37	Abnormality of the renal medulla (HP:0100957)	2.49313620
38	Agitation (HP:0000713)	2.45970346
39	Lipid accumulation in hepatocytes (HP:0006561)	2.45889979
40	Abnormality of reticulocytes (HP:0004312)	2.45628070
41	Maternal diabetes (HP:0009800)	2.45125025
42	True hermaphroditism (HP:0010459)	2.43370742
43	Anencephaly (HP:0002323)	2.42041885
44	Increased hepatocellular lipid droplets (HP:0006565)	2.40390362
45	Adrenal hypoplasia (HP:0000835)	2.39881330
46	Hepatic necrosis (HP:0002605)	2.39244201
47	Type II lissencephaly (HP:0007260)	2.31952445
48	Sclerocornea (HP:0000647)	2.30243368
49	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.27667260
50	Depressed nasal ridge (HP:0000457)	2.24564798
51	Renal Fanconi syndrome (HP:0001994)	2.23764783
52	Abnormal drinking behavior (HP:0030082)	2.19685825
53	Polydipsia (HP:0001959)	2.19685825
54	Gait imbalance (HP:0002141)	2.19180244
55	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.18387328
56	Leukodystrophy (HP:0002415)	2.18095724
57	Cystic liver disease (HP:0006706)	2.16530337
58	Abnormality of DNA repair (HP:0003254)	2.14221137
59	Abnormal rod and cone electroretinograms (HP:0008323)	2.14060618
60	Cerebellar dysplasia (HP:0007033)	2.10232909
61	Increased serum lactate (HP:0002151)	2.08975329
62	Tubular atrophy (HP:0000092)	2.08242135
63	Asplenia (HP:0001746)	2.06073734
64	Congenital primary aphakia (HP:0007707)	2.04127139
65	Increased intramyocellular lipid droplets (HP:0012240)	1.99153242
66	Nephrogenic diabetes insipidus (HP:0009806)	1.97718064
67	Enlarged kidneys (HP:0000105)	1.97261244
68	Poor suck (HP:0002033)	1.92292044
69	Hyperglycinemia (HP:0002154)	1.92211537
70	Lactic acidosis (HP:0003128)	1.90344285
71	Hypoplasia of the ulna (HP:0003022)	1.85726183
72	Abnormality of renal resorption (HP:0011038)	1.85611226
73	Oligodactyly (hands) (HP:0001180)	1.85120676
74	Polyuria (HP:0000103)	1.83817377
75	Holoprosencephaly (HP:0001360)	1.83805703
76	Abolished electroretinogram (ERG) (HP:0000550)	1.83641598
77	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.80266602
78	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.80266602
79	Abnormality of the labia minora (HP:0012880)	1.80155374
80	Anterior segment dysgenesis (HP:0007700)	1.79070657
81	Optic nerve hypoplasia (HP:0000609)	1.78661140
82	Growth hormone deficiency (HP:0000824)	1.76833299
83	Congenital hepatic fibrosis (HP:0002612)	1.75878781
84	Postaxial foot polydactyly (HP:0001830)	1.75834561
85	Oligodactyly (HP:0012165)	1.75571387
86	Partial duplication of thumb phalanx (HP:0009944)	1.75324524
87	Increased muscle lipid content (HP:0009058)	1.75221839
88	Hypoplasia of the radius (HP:0002984)	1.73962290
89	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.73549556
90	Lethargy (HP:0001254)	1.72892297
91	11 pairs of ribs (HP:0000878)	1.72120276
92	X-linked dominant inheritance (HP:0001423)	1.71588880
93	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.71441480
94	Congenital stationary night blindness (HP:0007642)	1.69245686
95	Absent septum pellucidum (HP:0001331)	1.67462492
96	Chronic hepatic failure (HP:0100626)	1.66237195
97	Exercise intolerance (HP:0003546)	1.66165720
98	Polyphagia (HP:0002591)	1.65453209
99	Decreased central vision (HP:0007663)	1.63725418
100	Abnormality of the renal cortex (HP:0011035)	1.63132286

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	4.61273700
2	PDK2	3.28861866
3	PIK3CA	2.62721207
4	PINK1	2.59090440
5	DYRK2	2.57774774
6	STK16	2.48332417
7	EPHB2	2.16125625
8	TIE1	2.08465184
9	CDK19	2.06181903
10	EPHA4	2.05107885
11	CDC7	2.04111095
12	STK39	1.93332984
13	CASK	1.88225619
14	ADRBK2	1.80809398
15	GRK1	1.78388396
16	BCKDK	1.76668699
17	ZAK	1.75947744
18	LRRK2	1.72887926
19	NEK1	1.71761155
20	NME2	1.63677160
21	NTRK2	1.50029408
22	WNK3	1.48472819
23	OXSR1	1.46409423
24	TLK1	1.42863022
25	MAP3K11	1.40788515
26	CAMKK2	1.33131472
27	ABL2	1.23859336
28	STK11	1.17903486
29	MAP2K7	1.17283075
30	PRKCG	1.14116403
31	BMPR1B	1.11122886
32	CAMKK1	1.08583328
33	MAPK13	1.07591370
34	ADRBK1	1.06082140
35	CAMK1	1.05136075
36	NUAK1	0.98272838
37	TNIK	0.95602944
38	TYRO3	0.92732106
39	MARK1	0.91809654
40	RPS6KA6	0.89994190
41	RPS6KA2	0.89271098
42	WNK1	0.89192782
43	CHEK2	0.87498096
44	PRKCQ	0.86875114
45	MINK1	0.86804020
46	BRSK1	0.85614255
47	FRK	0.84908433
48	PRKCH	0.84083385
49	CAMK1D	0.83627742
50	DAPK3	0.82592638
51	CSNK1E	0.80557452
52	NME1	0.79587099
53	LIMK1	0.77985388
54	TXK	0.77892407
55	DYRK1B	0.77716457
56	CSNK2A2	0.75986092
57	PRKACA	0.73846202
58	PAK3	0.73601284
59	RPS6KC1	0.72213046
60	RPS6KL1	0.72213046
61	TRIM28	0.71940778
62	MAP3K4	0.71793722
63	INSRR	0.71632357
64	MAP3K9	0.68889879
65	DYRK3	0.68688489
66	AURKA	0.68112410
67	SGK223	0.67914849
68	SGK494	0.67914849
69	NTRK3	0.66815789
70	BRAF	0.65113881
71	PRKD3	0.64689626
72	AURKB	0.61589486
73	NEK2	0.60641589
74	PLK2	0.60298289
75	RPS6KA5	0.58743925
76	PRKCZ	0.57759753
77	PLK1	0.56285169
78	CSNK1G2	0.56158644
79	ILK	0.53156519
80	ATR	0.52191986
81	CSNK2A1	0.49935380
82	PLK4	0.49668321
83	CAMK2A	0.49153025
84	TAOK3	0.48085724
85	DMPK	0.47711606
86	PRKDC	0.47406568
87	MAP2K2	0.47016505
88	PRKCA	0.44197441
89	SGK1	0.44061542
90	NTRK1	0.43900857
91	OBSCN	0.43819185
92	CSNK1G3	0.43594896
93	PLK3	0.42508374
94	PIM2	0.42482459
95	PRKCI	0.41972075
96	CAMK1G	0.41941655
97	ERBB2	0.41322680
98	PRKCD	0.40871532
99	PHKG2	0.40243726
100	PHKG1	0.40243726

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.49208427
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.62676914
3	Parkinsons disease_Homo sapiens_hsa05012	4.01227216
4	Cardiac muscle contraction_Homo sapiens_hsa04260	3.02974841
5	Huntingtons disease_Homo sapiens_hsa05016	2.89490809
6	Alzheimers disease_Homo sapiens_hsa05010	2.66625766
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.58171189
8	RNA polymerase_Homo sapiens_hsa03020	2.06719856
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.98068261
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.95164034
11	Protein export_Homo sapiens_hsa03060	1.91459415
12	Sulfur relay system_Homo sapiens_hsa04122	1.87467792
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.67328050
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.66822463
15	Proteasome_Homo sapiens_hsa03050	1.61846267
16	Folate biosynthesis_Homo sapiens_hsa00790	1.49358658
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.46147430
18	Nicotine addiction_Homo sapiens_hsa05033	1.43360066
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.41421315
20	Phototransduction_Homo sapiens_hsa04744	1.41321601
21	Fat digestion and absorption_Homo sapiens_hsa04975	1.41020587
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.21896056
23	RNA degradation_Homo sapiens_hsa03018	1.19839257
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.17671960
25	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.09855130
26	Morphine addiction_Homo sapiens_hsa05032	1.08096605
27	Basal transcription factors_Homo sapiens_hsa03022	1.06197623
28	Steroid biosynthesis_Homo sapiens_hsa00100	1.05638282
29	One carbon pool by folate_Homo sapiens_hsa00670	1.03240219
30	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.01986877
31	Homologous recombination_Homo sapiens_hsa03440	0.97995197
32	Propanoate metabolism_Homo sapiens_hsa00640	0.97271213
33	Mismatch repair_Homo sapiens_hsa03430	0.96256134
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.94987144
35	Basal cell carcinoma_Homo sapiens_hsa05217	0.94719032
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.93996350
37	Nucleotide excision repair_Homo sapiens_hsa03420	0.91438399
38	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.90653311
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.90455983
40	Pyrimidine metabolism_Homo sapiens_hsa00240	0.89954122
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.88736132
42	Asthma_Homo sapiens_hsa05310	0.88065693
43	Ether lipid metabolism_Homo sapiens_hsa00565	0.85568054
44	Peroxisome_Homo sapiens_hsa04146	0.83531803
45	Butanoate metabolism_Homo sapiens_hsa00650	0.80320394
46	Insulin secretion_Homo sapiens_hsa04911	0.75769193
47	Metabolic pathways_Homo sapiens_hsa01100	0.70892904
48	Pyruvate metabolism_Homo sapiens_hsa00620	0.70618731
49	Olfactory transduction_Homo sapiens_hsa04740	0.66987834
50	GABAergic synapse_Homo sapiens_hsa04727	0.66424592
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.64090916
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.62547168
53	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62207174
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.62012393
55	Caffeine metabolism_Homo sapiens_hsa00232	0.62011061
56	Purine metabolism_Homo sapiens_hsa00230	0.61762562
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.57116821
58	Base excision repair_Homo sapiens_hsa03410	0.56542452
59	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.56194165
60	Regulation of autophagy_Homo sapiens_hsa04140	0.55889741
61	Fatty acid degradation_Homo sapiens_hsa00071	0.55297394
62	Allograft rejection_Homo sapiens_hsa05330	0.54593995
63	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.54056207
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.53887193
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.53337523
66	Spliceosome_Homo sapiens_hsa03040	0.51972107
67	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.51409428
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50585744
69	Sulfur metabolism_Homo sapiens_hsa00920	0.50295499
70	Axon guidance_Homo sapiens_hsa04360	0.50106947
71	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.48671308
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48293554
73	Type I diabetes mellitus_Homo sapiens_hsa04940	0.47027198
74	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46796057
75	Retinol metabolism_Homo sapiens_hsa00830	0.46296941
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45936972
77	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.45060832
78	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.44829135
79	Notch signaling pathway_Homo sapiens_hsa04330	0.44672122
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44326078
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.44137824
82	Graft-versus-host disease_Homo sapiens_hsa05332	0.41613594
83	RNA transport_Homo sapiens_hsa03013	0.39115779
84	Hippo signaling pathway_Homo sapiens_hsa04390	0.38864610
85	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.37553641
86	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.37190409
87	Glutamatergic synapse_Homo sapiens_hsa04724	0.35936729
88	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.33425321
89	Taste transduction_Homo sapiens_hsa04742	0.32844425
90	DNA replication_Homo sapiens_hsa03030	0.31393714
91	Serotonergic synapse_Homo sapiens_hsa04726	0.30386137
92	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.30076785
93	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.26779771
94	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.25376370
95	Circadian entrainment_Homo sapiens_hsa04713	0.25370934
96	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.23707630
97	Mineral absorption_Homo sapiens_hsa04978	0.22864606
98	beta-Alanine metabolism_Homo sapiens_hsa00410	0.20575114
99	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.20035236
100	p53 signaling pathway_Homo sapiens_hsa04115	0.19521116

RPS24P17

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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