ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	9.48550099
2	viral transcription (GO:0019083)	8.74728372
3	maturation of SSU-rRNA (GO:0030490)	8.62011313
4	translational termination (GO:0006415)	8.37647140
5	ribosomal small subunit biogenesis (GO:0042274)	8.17292661
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.13837372
7	translational elongation (GO:0006414)	7.04514977
8	cotranslational protein targeting to membrane (GO:0006613)	7.00337749
9	protein targeting to ER (GO:0045047)	6.97081416
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.74027807
11	protein localization to endoplasmic reticulum (GO:0070972)	6.54886645
12	cellular protein complex disassembly (GO:0043624)	6.44320903
13	viral life cycle (GO:0019058)	6.14298765
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.12852850
15	ATP synthesis coupled proton transport (GO:0015986)	5.65373553
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.65373553
17	translational initiation (GO:0006413)	5.41731079
18	protein complex disassembly (GO:0043241)	5.39459938
19	protein neddylation (GO:0045116)	5.37334955
20	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.24371995
21	macromolecular complex disassembly (GO:0032984)	5.19737842
22	chaperone-mediated protein transport (GO:0072321)	5.19171968
23	ribosomal large subunit biogenesis (GO:0042273)	4.68961137
24	protein targeting to membrane (GO:0006612)	4.66746460
25	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.59332761
26	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.56723680
27	respiratory electron transport chain (GO:0022904)	4.47014566
28	electron transport chain (GO:0022900)	4.45587641
29	GTP biosynthetic process (GO:0006183)	4.36983075
30	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.36949586
31	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.27903979
32	protein complex biogenesis (GO:0070271)	4.27050771
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.25093660
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.25093660
35	NADH dehydrogenase complex assembly (GO:0010257)	4.25093660
36	translation (GO:0006412)	4.24693283
37	mRNA catabolic process (GO:0006402)	4.06817181
38	UTP biosynthetic process (GO:0006228)	3.90702341
39	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.89997448
40	regulation of cilium movement (GO:0003352)	3.88464940
41	mitochondrial respiratory chain complex assembly (GO:0033108)	3.75484910
42	UTP metabolic process (GO:0046051)	3.61197095
43	RNA catabolic process (GO:0006401)	3.60973362
44	cellular component biogenesis (GO:0044085)	3.59775761
45	tongue development (GO:0043586)	3.59596304
46	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.53479784
47	ribonucleoprotein complex biogenesis (GO:0022613)	3.52540353
48	hydrogen ion transmembrane transport (GO:1902600)	3.52317308
49	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.50848729
50	negative regulation of telomere maintenance (GO:0032205)	3.45929824
51	protein polyglutamylation (GO:0018095)	3.45130156
52	positive regulation of respiratory burst (GO:0060267)	3.37468457
53	epithelial cilium movement (GO:0003351)	3.33174995
54	nonmotile primary cilium assembly (GO:0035058)	3.31710620
55	behavioral response to nicotine (GO:0035095)	3.30320516
56	pyrimidine nucleotide catabolic process (GO:0006244)	3.27412611
57	ATP biosynthetic process (GO:0006754)	3.27110324
58	regulation of microtubule-based movement (GO:0060632)	3.19840765
59	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.15814394
60	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.15814394
61	establishment of protein localization to membrane (GO:0090150)	3.15567976
62	proton transport (GO:0015992)	3.12650196
63	substrate-independent telencephalic tangential migration (GO:0021826)	3.09369520
64	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.09369520
65	cell proliferation in forebrain (GO:0021846)	3.08975630
66	hydrogen transport (GO:0006818)	3.05066183
67	protein targeting (GO:0006605)	3.03633242
68	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.01171638
69	hypothalamus development (GO:0021854)	2.87107355
70	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.84925697
71	DNA deamination (GO:0045006)	2.84281998
72	intracellular protein transmembrane import (GO:0044743)	2.83527537
73	establishment of protein localization to organelle (GO:0072594)	2.82420813
74	aldehyde catabolic process (GO:0046185)	2.81639009
75	protein-cofactor linkage (GO:0018065)	2.81144437
76	dendritic spine morphogenesis (GO:0060997)	2.78304204
77	neuron fate determination (GO:0048664)	2.73232822
78	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.71844113
79	regulation of action potential (GO:0098900)	2.71388047
80	platelet dense granule organization (GO:0060155)	2.71309032
81	CTP metabolic process (GO:0046036)	2.70593288
82	CTP biosynthetic process (GO:0006241)	2.70593288
83	cytochrome complex assembly (GO:0017004)	2.69056098
84	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.68999285
85	respiratory chain complex IV assembly (GO:0008535)	2.67485073
86	base-excision repair, AP site formation (GO:0006285)	2.66386237
87	somite development (GO:0061053)	2.64601001
88	cilium movement (GO:0003341)	2.63614478
89	positive regulation of T cell apoptotic process (GO:0070234)	2.63194372
90	guanosine-containing compound biosynthetic process (GO:1901070)	2.62817018
91	ribonucleoprotein complex disassembly (GO:0032988)	2.61378385
92	cardiovascular system development (GO:0072358)	2.59227765
93	rRNA metabolic process (GO:0016072)	2.54869978
94	short-term memory (GO:0007614)	2.54589888
95	protein localization to membrane (GO:0072657)	2.54529805
96	nucleoside triphosphate biosynthetic process (GO:0009142)	2.54526758
97	rRNA processing (GO:0006364)	2.53720927
98	regulation of mitochondrial translation (GO:0070129)	2.52417427
99	maturation of 5.8S rRNA (GO:0000460)	2.51773703
100	deoxyribonucleotide catabolic process (GO:0009264)	2.51143777

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.93836418
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.63696718
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.33666133
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.22979831
5	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.11063781
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.66264793
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.63319703
8	VDR_22108803_ChIP-Seq_LS180_Human	2.47157622
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.27141178
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.25568326
11	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.20950667
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.13334285
13	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.87940141
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.85562976
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.81982246
16	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.75054750
17	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.74307140
18	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.72121917
19	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.69683079
20	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.64234826
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.60588459
22	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.58063174
23	TP53_22573176_ChIP-Seq_HFKS_Human	1.57526543
24	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.57339383
25	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.55426312
26	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.53667571
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.53255196
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.52817135
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.52688848
30	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.49174631
31	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.46235996
32	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.44204606
33	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.43593194
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41038499
35	TTF2_22483619_ChIP-Seq_HELA_Human	1.37204979
36	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.37147848
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37136868
38	XRN2_22483619_ChIP-Seq_HELA_Human	1.33885310
39	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.33571194
40	REST_21632747_ChIP-Seq_MESCs_Mouse	1.33545039
41	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.31639904
42	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.31036570
43	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30774766
44	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.29719806
45	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.29327119
46	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.29277111
47	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.29277111
48	EWS_26573619_Chip-Seq_HEK293_Human	1.25904669
49	ERA_21632823_ChIP-Seq_H3396_Human	1.24955874
50	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.23034533
51	TAF2_19829295_ChIP-Seq_ESCs_Human	1.21826593
52	NANOG_20526341_ChIP-Seq_ESCs_Human	1.21231795
53	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19771913
54	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.16004725
55	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.15670677
56	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.13837198
57	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.13788059
58	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.13470191
59	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.12536179
60	FUS_26573619_Chip-Seq_HEK293_Human	1.11802496
61	ELK1_19687146_ChIP-ChIP_HELA_Human	1.11286410
62	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.10360660
63	GABP_19822575_ChIP-Seq_HepG2_Human	1.08697239
64	AR_20517297_ChIP-Seq_VCAP_Human	1.08555808
65	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.07486127
66	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.06968408
67	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.05836937
68	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.04569383
69	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.03811043
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03609165
71	CIITA_25753668_ChIP-Seq_RAJI_Human	1.03296513
72	FOXP3_21729870_ChIP-Seq_TREG_Human	1.02864107
73	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.01445622
74	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.00790477
75	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.00359400
76	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.99235107
77	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.99129866
78	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.97582850
79	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.97170921
80	NCOR_22424771_ChIP-Seq_293T_Human	0.96162724
81	CTCF_20526341_ChIP-Seq_ESCs_Human	0.95140824
82	P300_27268052_Chip-Seq_Bcells_Human	0.95138462
83	SOX2_21211035_ChIP-Seq_LN229_Human	0.94645009
84	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.92746422
85	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.91989657
86	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.91989657
87	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.91067327
88	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.90646420
89	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.90226309
90	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.89306284
91	BCL6_27268052_Chip-Seq_Bcells_Human	0.88601179
92	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.88548450
93	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.87889432
94	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.87826134
95	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.87363450
96	P300_19829295_ChIP-Seq_ESCs_Human	0.87104632
97	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.87000953
98	MYC_19829295_ChIP-Seq_ESCs_Human	0.86880130
99	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.86806154
100	E2F1_20622854_ChIP-Seq_HELA_Human	0.86619795

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.92933841
2	MP0006292_abnormal_olfactory_placode	4.33248333
3	MP0003646_muscle_fatigue	2.51355577
4	MP0002653_abnormal_ependyma_morphology	2.42412628
5	MP0004142_abnormal_muscle_tone	2.32278878
6	MP0008789_abnormal_olfactory_epithelium	2.23948934
7	MP0003122_maternal_imprinting	2.21860705
8	MP0001485_abnormal_pinna_reflex	2.18127005
9	MP0003878_abnormal_ear_physiology	2.17138021
10	MP0005377_hearing/vestibular/ear_phenot	2.17138021
11	MP0001529_abnormal_vocalization	2.16899662
12	MP0003136_yellow_coat_color	2.11433863
13	MP0003183_abnormal_peptide_metabolism	2.07973868
14	MP0001984_abnormal_olfaction	2.06158474
15	MP0003123_paternal_imprinting	2.05172133
16	MP0008877_abnormal_DNA_methylation	2.00251735
17	MP0003787_abnormal_imprinting	1.98664390
18	MP0005499_abnormal_olfactory_system	1.92650340
19	MP0005394_taste/olfaction_phenotype	1.92650340
20	MP0001293_anophthalmia	1.89930289
21	MP0000566_synostosis	1.88805604
22	MP0006276_abnormal_autonomic_nervous	1.86302300
23	MP0001986_abnormal_taste_sensitivity	1.83646691
24	MP0003880_abnormal_central_pattern	1.78391210
25	MP0004885_abnormal_endolymph	1.76140857
26	MP0002876_abnormal_thyroid_physiology	1.71206538
27	MP0002102_abnormal_ear_morphology	1.60206401
28	MP0002837_dystrophic_cardiac_calcinosis	1.56461742
29	MP0002272_abnormal_nervous_system	1.55411496
30	MP0001968_abnormal_touch/_nociception	1.55290824
31	MP0000049_abnormal_middle_ear	1.52700516
32	MP0002638_abnormal_pupillary_reflex	1.52513777
33	MP0005551_abnormal_eye_electrophysiolog	1.51861805
34	MP0000778_abnormal_nervous_system	1.45474792
35	MP0004742_abnormal_vestibular_system	1.41989766
36	MP0001486_abnormal_startle_reflex	1.41820724
37	MP0003121_genomic_imprinting	1.40304587
38	MP0008872_abnormal_physiological_respon	1.37209962
39	MP0002938_white_spotting	1.29285244
40	MP0008058_abnormal_DNA_repair	1.26365045
41	MP0002138_abnormal_hepatobiliary_system	1.26336432
42	MP0008875_abnormal_xenobiotic_pharmacok	1.23114799
43	MP0010030_abnormal_orbit_morphology	1.22934008
44	MP0000026_abnormal_inner_ear	1.22832701
45	MP0003186_abnormal_redox_activity	1.21941607
46	MP0000631_abnormal_neuroendocrine_gland	1.21379376
47	MP0005389_reproductive_system_phenotype	1.20557778
48	MP0001970_abnormal_pain_threshold	1.20162312
49	MP0002557_abnormal_social/conspecific_i	1.19283154
50	MP0002160_abnormal_reproductive_system	1.19114172
51	MP0001440_abnormal_grooming_behavior	1.17946430
52	MP0005646_abnormal_pituitary_gland	1.17012174
53	MP0001905_abnormal_dopamine_level	1.16609089
54	MP0001919_abnormal_reproductive_system	1.15997541
55	MP0004147_increased_porphyrin_level	1.15731290
56	MP0005195_abnormal_posterior_eye	1.14595048
57	MP0002736_abnormal_nociception_after	1.11875865
58	MP0005174_abnormal_tail_pigmentation	1.10585111
59	MP0003938_abnormal_ear_development	1.10048178
60	MP0005645_abnormal_hypothalamus_physiol	1.09976497
61	MP0008775_abnormal_heart_ventricle	1.09066475
62	MP0000955_abnormal_spinal_cord	1.06964793
63	MP0002095_abnormal_skin_pigmentation	1.06726728
64	MP0009745_abnormal_behavioral_response	1.05007993
65	MP0002734_abnormal_mechanical_nocicepti	1.03912960
66	MP0000569_abnormal_digit_pigmentation	1.02392653
67	MP0001963_abnormal_hearing_physiology	1.02352032
68	MP0002733_abnormal_thermal_nociception	1.02337140
69	MP0002277_abnormal_respiratory_mucosa	1.02167715
70	MP0002234_abnormal_pharynx_morphology	1.00779028
71	MP0004133_heterotaxia	1.00466242
72	MP0002752_abnormal_somatic_nervous	0.99643534
73	MP0002572_abnormal_emotion/affect_behav	0.99576008
74	MP0009046_muscle_twitch	0.98609498
75	MP0006072_abnormal_retinal_apoptosis	0.97984108
76	MP0002063_abnormal_learning/memory/cond	0.95924963
77	MP0004145_abnormal_muscle_electrophysio	0.95434118
78	MP0003635_abnormal_synaptic_transmissio	0.92842620
79	MP0002735_abnormal_chemical_nociception	0.91000050
80	MP0004043_abnormal_pH_regulation	0.90803522
81	MP0002233_abnormal_nose_morphology	0.88345070
82	MP0002249_abnormal_larynx_morphology	0.87808850
83	MP0002184_abnormal_innervation	0.86874948
84	MP0005084_abnormal_gallbladder_morpholo	0.84026825
85	MP0000230_abnormal_systemic_arterial	0.79237222
86	MP0002163_abnormal_gland_morphology	0.78997549
87	MP0000427_abnormal_hair_cycle	0.77651825
88	MP0009780_abnormal_chondrocyte_physiolo	0.76986528
89	MP0003567_abnormal_fetal_cardiomyocyte	0.76776402
90	MP0002064_seizures	0.73386482
91	MP0002882_abnormal_neuron_morphology	0.69991240
92	MP0008995_early_reproductive_senescence	0.69525097
93	MP0003937_abnormal_limbs/digits/tail_de	0.68438613
94	MP0004924_abnormal_behavior	0.64982939
95	MP0005386_behavior/neurological_phenoty	0.64982939
96	MP0002067_abnormal_sensory_capabilities	0.64958532
97	MP0002152_abnormal_brain_morphology	0.63742569
98	MP0003119_abnormal_digestive_system	0.62665165
99	MP0005253_abnormal_eye_physiology	0.61578758
100	MP0005391_vision/eye_phenotype	0.61060732

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.84148895
2	Acute necrotizing encephalopathy (HP:0006965)	5.27466765
3	Abnormality of cells of the erythroid lineage (HP:0012130)	5.26468172
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.73328290
5	Acute encephalopathy (HP:0006846)	4.37878116
6	Progressive macrocephaly (HP:0004481)	4.33052306
7	Mitochondrial inheritance (HP:0001427)	3.99922897
8	Macrocytic anemia (HP:0001972)	3.87551837
9	Absent/shortened dynein arms (HP:0200106)	3.84743455
10	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.84743455
11	Abnormal number of erythroid precursors (HP:0012131)	3.81445081
12	Abnormality of midbrain morphology (HP:0002418)	3.64360959
13	Molar tooth sign on MRI (HP:0002419)	3.64360959
14	Hepatocellular necrosis (HP:0001404)	3.61583146
15	Increased CSF lactate (HP:0002490)	3.61122657
16	Absent thumb (HP:0009777)	3.41766428
17	Pancreatic fibrosis (HP:0100732)	3.41046322
18	Hepatic necrosis (HP:0002605)	3.35289686
19	Septo-optic dysplasia (HP:0100842)	3.33358221
20	Pallor (HP:0000980)	3.25119188
21	3-Methylglutaconic aciduria (HP:0003535)	3.12978563
22	Cerebral edema (HP:0002181)	3.10369938
23	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.07136575
24	Partial duplication of thumb phalanx (HP:0009944)	2.92394387
25	Pancreatic cysts (HP:0001737)	2.90853292
26	Optic disc pallor (HP:0000543)	2.82989093
27	Abnormal respiratory epithelium morphology (HP:0012253)	2.80114960
28	Abnormal respiratory motile cilium morphology (HP:0005938)	2.80114960
29	Abnormality of DNA repair (HP:0003254)	2.76288587
30	Abnormal ciliary motility (HP:0012262)	2.66266212
31	Deep palmar crease (HP:0006191)	2.59418916
32	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.56473700
33	Colon cancer (HP:0003003)	2.55943622
34	Hypoplasia of the radius (HP:0002984)	2.53604123
35	Supernumerary spleens (HP:0009799)	2.51655855
36	Postaxial foot polydactyly (HP:0001830)	2.51045778
37	Nephronophthisis (HP:0000090)	2.50643648
38	Rib fusion (HP:0000902)	2.48187761
39	Asplenia (HP:0001746)	2.46695996
40	Stenosis of the external auditory canal (HP:0000402)	2.41184437
41	Medial flaring of the eyebrow (HP:0010747)	2.40991810
42	True hermaphroditism (HP:0010459)	2.40889248
43	Sclerocornea (HP:0000647)	2.40292196
44	Leukodystrophy (HP:0002415)	2.38436608
45	Partial duplication of the phalanx of hand (HP:0009999)	2.38011717
46	Myokymia (HP:0002411)	2.37489698
47	Abnormal respiratory motile cilium physiology (HP:0012261)	2.37014244
48	Increased serum lactate (HP:0002151)	2.35798954
49	Cystic liver disease (HP:0006706)	2.30053622
50	Hyperthyroidism (HP:0000836)	2.24280653
51	Forearm undergrowth (HP:0009821)	2.22301400
52	Congenital stationary night blindness (HP:0007642)	2.18130535
53	Lipid accumulation in hepatocytes (HP:0006561)	2.15101677
54	Duplication of thumb phalanx (HP:0009942)	2.14273496
55	Respiratory failure (HP:0002878)	2.14007277
56	Lactic acidosis (HP:0003128)	2.09684384
57	Abnormal hemoglobin (HP:0011902)	2.06451473
58	11 pairs of ribs (HP:0000878)	2.06030875
59	Type II lissencephaly (HP:0007260)	2.06013818
60	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.05745232
61	Abnormality of the renal medulla (HP:0100957)	2.04537258
62	Thyroid-stimulating hormone excess (HP:0002925)	2.03624620
63	Anencephaly (HP:0002323)	2.03621107
64	Abnormality of the diencephalon (HP:0010662)	2.02872522
65	Increased hepatocellular lipid droplets (HP:0006565)	2.02456372
66	Hypoplasia of the ulna (HP:0003022)	2.01487316
67	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.00519405
68	Tubular atrophy (HP:0000092)	1.99275163
69	Tubulointerstitial nephritis (HP:0001970)	1.96207582
70	Depressed nasal ridge (HP:0000457)	1.96166272
71	Abnormality of the labia minora (HP:0012880)	1.93708927
72	Pachygyria (HP:0001302)	1.92575159
73	Pendular nystagmus (HP:0012043)	1.89306484
74	Triphalangeal thumb (HP:0001199)	1.88690967
75	Gait imbalance (HP:0002141)	1.87582705
76	Constricted visual fields (HP:0001133)	1.87485130
77	Maternal diabetes (HP:0009800)	1.87265139
78	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.87093277
79	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.87093277
80	Exercise intolerance (HP:0003546)	1.85916664
81	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.84286406
82	Polyphagia (HP:0002591)	1.83847786
83	Lethargy (HP:0001254)	1.82884161
84	Ectopic kidney (HP:0000086)	1.81619948
85	Abnormality of reticulocytes (HP:0004312)	1.80768020
86	Abnormal rod and cone electroretinograms (HP:0008323)	1.77595673
87	Facial hemangioma (HP:0000329)	1.74182006
88	Agitation (HP:0000713)	1.72744458
89	Congenital primary aphakia (HP:0007707)	1.71833147
90	Optic nerve hypoplasia (HP:0000609)	1.71012309
91	Abnormality of the aortic arch (HP:0012303)	1.67872206
92	Oligodactyly (HP:0012165)	1.67493600
93	Narrow forehead (HP:0000341)	1.66492871
94	Preaxial hand polydactyly (HP:0001177)	1.64283692
95	Abnormality of magnesium homeostasis (HP:0004921)	1.62680211
96	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.62304674
97	Keratoconus (HP:0000563)	1.60388917
98	Increased corneal curvature (HP:0100692)	1.60388917
99	Anophthalmia (HP:0000528)	1.59397295
100	Hypomagnesemia (HP:0002917)	1.58957338

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	4.29920012
2	MAP4K2	3.91148046
3	FRK	2.65810983
4	STK16	2.61129329
5	PINK1	2.55424258
6	LRRK2	2.47549532
7	TXK	2.41113673
8	ADRBK2	2.37021627
9	DYRK2	2.17694143
10	STK39	2.14898465
11	CDK8	2.03135063
12	PIK3CA	1.96568680
13	GRK1	1.95322124
14	BRAF	1.62184345
15	BCKDK	1.59900775
16	CDK19	1.55702177
17	PDK2	1.54549934
18	TIE1	1.51127355
19	MAP3K11	1.49160422
20	MARK1	1.47758306
21	EPHB2	1.46923132
22	TAOK3	1.42942411
23	WNK1	1.28942794
24	DAPK2	1.28527576
25	TLK1	1.27015986
26	MAP2K2	1.25610879
27	CAMK1	1.25337383
28	NME2	1.20951310
29	DAPK3	1.12497508
30	PRKCG	1.12359066
31	PASK	1.11642684
32	MAP3K12	1.11402053
33	NEK1	1.08440382
34	MAP3K13	1.08288272
35	BMPR1B	1.07864803
36	MAP3K9	1.06659528
37	NTRK2	1.03321823
38	NUAK1	1.02073847
39	ADRBK1	1.01432258
40	VRK2	0.99610520
41	LIMK1	0.96415186
42	CAMKK1	0.96342054
43	BTK	0.94990029
44	OXSR1	0.93736943
45	TEC	0.93590763
46	MAP2K7	0.93383592
47	PAK3	0.90051628
48	INSRR	0.89454451
49	CASK	0.89447338
50	CDC7	0.88144574
51	WNK3	0.86703459
52	ABL2	0.84279251
53	ARAF	0.80736569
54	TYRO3	0.78266760
55	PRKCI	0.77374549
56	PRKACA	0.75539226
57	CSNK2A2	0.73280919
58	PRKCQ	0.72693748
59	PRKCZ	0.71015011
60	MAPK13	0.70383845
61	CSNK1E	0.69582717
62	ZAK	0.67985728
63	KIT	0.66853572
64	EPHA4	0.64996777
65	CAMKK2	0.63954675
66	DYRK1B	0.62544442
67	AURKB	0.62087737
68	MINK1	0.61929310
69	MOS	0.58754414
70	NME1	0.58172175
71	MST4	0.58025908
72	PHKG2	0.57670611
73	PHKG1	0.57670611
74	OBSCN	0.56543964
75	AURKA	0.55029747
76	MAP3K4	0.54353897
77	RPS6KA6	0.54053799
78	CAMK2A	0.53553439
79	PRKCA	0.51855351
80	ITK	0.50647694
81	FGFR2	0.50484677
82	DYRK1A	0.50225401
83	STK11	0.49591351
84	CSNK2A1	0.47237674
85	MAPK15	0.47066409
86	PRKCE	0.45778101
87	SGK1	0.45602308
88	SYK	0.44979151
89	NEK2	0.43079300
90	PLK1	0.41442342
91	CDC42BPA	0.38407777
92	ATR	0.37415364
93	SGK494	0.37030105
94	SGK223	0.37030105
95	PRKCD	0.36821793
96	PLK2	0.35783060
97	CSNK1A1	0.34998805
98	ILK	0.34063476
99	RPS6KA3	0.33914580
100	PAK2	0.33290910

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.17373594
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.88010246
3	Parkinsons disease_Homo sapiens_hsa05012	4.03125583
4	Cardiac muscle contraction_Homo sapiens_hsa04260	3.35173217
5	Alzheimers disease_Homo sapiens_hsa05010	2.93356824
6	Huntingtons disease_Homo sapiens_hsa05016	2.89088287
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.64271885
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.49246219
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.31126706
10	Protein export_Homo sapiens_hsa03060	1.99797470
11	Asthma_Homo sapiens_hsa05310	1.91983465
12	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.81277563
13	Proteasome_Homo sapiens_hsa03050	1.80052018
14	RNA polymerase_Homo sapiens_hsa03020	1.75833600
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.67023896
16	RNA degradation_Homo sapiens_hsa03018	1.58194039
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.49053530
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.47220335
19	Phototransduction_Homo sapiens_hsa04744	1.37375068
20	Peroxisome_Homo sapiens_hsa04146	1.33340054
21	Basal transcription factors_Homo sapiens_hsa03022	1.25618446
22	Nicotine addiction_Homo sapiens_hsa05033	1.16415361
23	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.15059362
24	Olfactory transduction_Homo sapiens_hsa04740	1.11533522
25	Homologous recombination_Homo sapiens_hsa03440	1.10478184
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.08014470
27	Butanoate metabolism_Homo sapiens_hsa00650	1.07607291
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.05167060
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.02442220
30	Sulfur relay system_Homo sapiens_hsa04122	1.00368027
31	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.99732534
32	Allograft rejection_Homo sapiens_hsa05330	0.99152281
33	Morphine addiction_Homo sapiens_hsa05032	0.94272326
34	Nucleotide excision repair_Homo sapiens_hsa03420	0.94096915
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.92825861
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.90120934
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.88031999
38	Graft-versus-host disease_Homo sapiens_hsa05332	0.85909493
39	Nitrogen metabolism_Homo sapiens_hsa00910	0.85079305
40	Pyrimidine metabolism_Homo sapiens_hsa00240	0.81509687
41	One carbon pool by folate_Homo sapiens_hsa00670	0.81286534
42	Insulin secretion_Homo sapiens_hsa04911	0.77642030
43	Collecting duct acid secretion_Homo sapiens_hsa04966	0.73884867
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.73833437
45	Retinol metabolism_Homo sapiens_hsa00830	0.70476616
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.68869060
47	Metabolic pathways_Homo sapiens_hsa01100	0.67918582
48	Type I diabetes mellitus_Homo sapiens_hsa04940	0.67635944
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.67505852
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67101623
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.65894452
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.64767782
53	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.63906242
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63528713
55	Basal cell carcinoma_Homo sapiens_hsa05217	0.61434963
56	Base excision repair_Homo sapiens_hsa03410	0.61281272
57	Non-homologous end-joining_Homo sapiens_hsa03450	0.59715564
58	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.58806390
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.57634359
60	GABAergic synapse_Homo sapiens_hsa04727	0.55821807
61	Purine metabolism_Homo sapiens_hsa00230	0.51738944
62	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.51101598
63	Steroid biosynthesis_Homo sapiens_hsa00100	0.50809553
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.50807662
65	Serotonergic synapse_Homo sapiens_hsa04726	0.49797974
66	Rheumatoid arthritis_Homo sapiens_hsa05323	0.49177143
67	Fatty acid degradation_Homo sapiens_hsa00071	0.48422626
68	Ether lipid metabolism_Homo sapiens_hsa00565	0.48170062
69	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.47098823
70	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.44819934
71	Notch signaling pathway_Homo sapiens_hsa04330	0.43919336
72	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.43896660
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43890940
74	Caffeine metabolism_Homo sapiens_hsa00232	0.41203786
75	Primary immunodeficiency_Homo sapiens_hsa05340	0.40812984
76	Propanoate metabolism_Homo sapiens_hsa00640	0.40405404
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.39694833
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.39364196
79	Arginine and proline metabolism_Homo sapiens_hsa00330	0.38906380
80	Glutamatergic synapse_Homo sapiens_hsa04724	0.36582331
81	Salivary secretion_Homo sapiens_hsa04970	0.35272889
82	Taste transduction_Homo sapiens_hsa04742	0.35114772
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.34509308
84	Circadian entrainment_Homo sapiens_hsa04713	0.34396727
85	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.33388702
86	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.33203582
87	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.32620205
88	Axon guidance_Homo sapiens_hsa04360	0.31662423
89	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.31099255
90	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.29876859
91	RNA transport_Homo sapiens_hsa03013	0.28233387
92	Spliceosome_Homo sapiens_hsa03040	0.25493911
93	Folate biosynthesis_Homo sapiens_hsa00790	0.24534455
94	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.24181293
95	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.22205689
96	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.22194403
97	Dopaminergic synapse_Homo sapiens_hsa04728	0.21636502
98	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.21089444
99	Antigen processing and presentation_Homo sapiens_hsa04612	0.20694269
100	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.19649800

RPS24P18

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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