ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cornea development in camera-type eye (GO:0061303)	9.99236331
2	viral transcription (GO:0019083)	8.18783865
3	positive regulation of odontogenesis (GO:0042482)	7.97295500
4	translational termination (GO:0006415)	7.71428266
5	nephron tubule formation (GO:0072079)	7.31076976
6	ATP synthesis coupled proton transport (GO:0015986)	7.29264424
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	7.29264424
8	cotranslational protein targeting to membrane (GO:0006613)	6.43608307
9	translational elongation (GO:0006414)	6.41862967
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.38404131
11	protein targeting to ER (GO:0045047)	6.23003524
12	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.04082549
13	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.95623399
14	viral life cycle (GO:0019058)	5.91798220
15	cellular protein complex disassembly (GO:0043624)	5.91569134
16	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.91349346
17	protein localization to endoplasmic reticulum (GO:0070972)	5.90390250
18	protein neddylation (GO:0045116)	5.52350921
19	protein complex disassembly (GO:0043241)	5.14255762
20	macromolecular complex disassembly (GO:0032984)	4.96195538
21	translational initiation (GO:0006413)	4.93224397
22	GTP biosynthetic process (GO:0006183)	4.91416618
23	chaperone-mediated protein transport (GO:0072321)	4.90431509
24	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.73459868
25	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	4.71875279
26	oxidative phosphorylation (GO:0006119)	4.67143685
27	ATP biosynthetic process (GO:0006754)	4.65704329
28	purine nucleoside triphosphate biosynthetic process (GO:0009145)	4.59086723
29	ribonucleoside triphosphate biosynthetic process (GO:0009201)	4.49485141
30	UTP biosynthetic process (GO:0006228)	4.49011263
31	CTP biosynthetic process (GO:0006241)	4.43191551
32	CTP metabolic process (GO:0046036)	4.43191551
33	ribosomal large subunit biogenesis (GO:0042273)	4.35652661
34	protein targeting to membrane (GO:0006612)	4.30801999
35	ribosomal small subunit assembly (GO:0000028)	4.27651169
36	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.17025656
37	ribonucleoprotein complex biogenesis (GO:0022613)	4.16042922
38	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	4.15244631
39	UTP metabolic process (GO:0046051)	4.11269188
40	spinal cord association neuron differentiation (GO:0021527)	4.07303350
41	pyrimidine nucleotide catabolic process (GO:0006244)	4.00006206
42	respiratory electron transport chain (GO:0022904)	3.92786859
43	mRNA catabolic process (GO:0006402)	3.92747869
44	electron transport chain (GO:0022900)	3.91650629
45	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.89211872
46	myeloid cell homeostasis (GO:0002262)	3.86844673
47	peptidyl-histidine modification (GO:0018202)	3.83036004
48	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.81669208
49	base-excision repair, AP site formation (GO:0006285)	3.79919655
50	translation (GO:0006412)	3.78584700
51	cellular component biogenesis (GO:0044085)	3.75384406
52	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.69580682
53	nucleoside triphosphate biosynthetic process (GO:0009142)	3.67933965
54	protein complex biogenesis (GO:0070271)	3.66605356
55	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.64044051
56	substrate-independent telencephalic tangential migration (GO:0021826)	3.64044051
57	guanosine-containing compound biosynthetic process (GO:1901070)	3.61770960
58	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.58661628
59	NADH dehydrogenase complex assembly (GO:0010257)	3.58661628
60	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.58661628
61	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.57072470
62	RNA catabolic process (GO:0006401)	3.43301746
63	mitochondrion transport along microtubule (GO:0047497)	3.39279447
64	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	3.39279447
65	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.37125747
66	viral protein processing (GO:0019082)	3.35547538
67	establishment of mitochondrion localization (GO:0051654)	3.28276464
68	hydrogen ion transmembrane transport (GO:1902600)	3.25574796
69	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	3.25177772
70	regulation of cellular respiration (GO:0043457)	3.25049313
71	coenzyme catabolic process (GO:0009109)	3.23374575
72	cell proliferation in forebrain (GO:0021846)	3.21363136
73	mitochondrial respiratory chain complex assembly (GO:0033108)	3.13158241
74	establishment of protein localization to membrane (GO:0090150)	3.10799558
75	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.09350186
76	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.08268861
77	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.04539486
78	cofactor catabolic process (GO:0051187)	3.04350619
79	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.03663289
80	DNA replication checkpoint (GO:0000076)	3.03121298
81	transmission of nerve impulse (GO:0019226)	2.99400344
82	response to redox state (GO:0051775)	2.95179471
83	organelle disassembly (GO:1903008)	2.91880923
84	rRNA processing (GO:0006364)	2.87005253
85	regulation of odontogenesis (GO:0042481)	2.86526713
86	water-soluble vitamin biosynthetic process (GO:0042364)	2.85585297
87	regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)	2.78639857
88	nucleoside diphosphate phosphorylation (GO:0006165)	2.77607644
89	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.76912634
90	rRNA metabolic process (GO:0016072)	2.74713364
91	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.72823854
92	cell wall macromolecule catabolic process (GO:0016998)	2.72252016
93	protein targeting (GO:0006605)	2.72223082
94	proline transport (GO:0015824)	2.71011689
95	proton transport (GO:0015992)	2.69771158
96	cerebral cortex radially oriented cell migration (GO:0021799)	2.69139211
97	cytochrome complex assembly (GO:0017004)	2.66132292
98	deoxyribonucleotide catabolic process (GO:0009264)	2.65947906
99	maturation of SSU-rRNA (GO:0030490)	11.6553006
100	ribosomal small subunit biogenesis (GO:0042274)	11.0260234

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.75903339
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.33352035
3	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.48082626
4	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.82008215
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.67166547
6	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.60730638
7	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.38591257
8	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.20231083
9	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.17647878
10	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.16619067
11	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.16497683
12	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.06679223
13	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.05593712
14	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.03033249
15	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.02302575
16	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.01840324
17	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.01428916
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.00228697
19	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.97131125
20	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.94344950
21	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.93152900
22	TTF2_22483619_ChIP-Seq_HELA_Human	1.90025262
23	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.87395963
24	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.85225160
25	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.81789837
26	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.80956213
27	P68_20966046_ChIP-Seq_HELA_Human	1.80534826
28	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.79987850
29	XRN2_22483619_ChIP-Seq_HELA_Human	1.78438053
30	CTCF_27219007_Chip-Seq_Bcells_Human	1.76539227
31	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.75488014
32	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.66148210
33	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.66148210
34	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.63878831
35	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.63536459
36	ERA_21632823_ChIP-Seq_H3396_Human	1.62679482
37	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.54077056
38	LXR_22292898_ChIP-Seq_THP-1_Human	1.53914635
39	BCL6_27268052_Chip-Seq_Bcells_Human	1.50884215
40	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.50425011
41	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.48120066
42	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.45911757
43	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.44970524
44	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.43339708
45	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.41275721
46	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.40405489
47	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.38917990
48	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.38467992
49	SMC4_20622854_ChIP-Seq_HELA_Human	1.37509527
50	CTCF_20526341_ChIP-Seq_ESCs_Human	1.36778662
51	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.36643019
52	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.36258915
53	MYC_18940864_ChIP-ChIP_HL60_Human	1.36101040
54	SA1_27219007_Chip-Seq_Bcells_Human	1.35453199
55	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.34118528
56	REST_21632747_ChIP-Seq_MESCs_Mouse	1.33964583
57	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.33439810
58	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.31573018
59	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.29701337
60	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.29675914
61	VDR_21846776_ChIP-Seq_THP-1_Human	1.26789017
62	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.26568789
63	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.20601143
64	GABP_19822575_ChIP-Seq_HepG2_Human	1.19473585
65	E2F1_20622854_ChIP-Seq_HELA_Human	1.19058097
66	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.17198210
67	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.17067641
68	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.14745322
69	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.14607607
70	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.13410180
71	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.12505978
72	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.12420260
73	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.11007221
74	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.10246111
75	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.09656413
76	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.09065774
77	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.08961722
78	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.08419718
79	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.06506785
80	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.06477164
81	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.06426116
82	PHF8_20622854_ChIP-Seq_HELA_Human	1.05534270
83	RAC3_21632823_ChIP-Seq_H3396_Human	1.05241788
84	BCOR_27268052_Chip-Seq_Bcells_Human	1.04930153
85	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.02093558
86	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.00991179
87	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.00166604
88	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.00067380
89	NANOG_20526341_ChIP-Seq_ESCs_Human	0.98706968
90	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.98652890
91	P53_21459846_ChIP-Seq_SAOS-2_Human	0.98431057
92	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.98279240
93	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.98246485
94	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.97971516
95	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.96852216
96	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.96693931
97	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.96383117
98	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.96348808
99	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.96160454
100	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.95611210

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.99454861
2	MP0003787_abnormal_imprinting	4.09334857
3	MP0006292_abnormal_olfactory_placode	4.04523108
4	MP0010030_abnormal_orbit_morphology	3.19317477
5	MP0003123_paternal_imprinting	3.12786280
6	MP0000566_synostosis	2.91772482
7	MP0003122_maternal_imprinting	2.78501884
8	MP0004859_abnormal_synaptic_plasticity	2.65909323
9	MP0002163_abnormal_gland_morphology	2.63328484
10	MP0003879_abnormal_hair_cell	2.39855936
11	MP0003121_genomic_imprinting	2.38030996
12	MP0002234_abnormal_pharynx_morphology	2.29564218
13	MP0008789_abnormal_olfactory_epithelium	2.26090172
14	MP0002653_abnormal_ependyma_morphology	2.10083376
15	MP0000778_abnormal_nervous_system	2.00714692
16	MP0000049_abnormal_middle_ear	2.00232283
17	MP0004142_abnormal_muscle_tone	1.97448258
18	MP0005499_abnormal_olfactory_system	1.90735843
19	MP0005394_taste/olfaction_phenotype	1.90735843
20	MP0006276_abnormal_autonomic_nervous	1.80399633
21	MP0001348_abnormal_lacrimal_gland	1.77488863
22	MP0004742_abnormal_vestibular_system	1.75651056
23	MP0008877_abnormal_DNA_methylation	1.74290514
24	MP0001905_abnormal_dopamine_level	1.74027905
25	MP0005423_abnormal_somatic_nervous	1.62245054
26	MP0000955_abnormal_spinal_cord	1.55153340
27	MP0003567_abnormal_fetal_cardiomyocyte	1.52796610
28	MP0003880_abnormal_central_pattern	1.51064328
29	MP0006072_abnormal_retinal_apoptosis	1.48400251
30	MP0005379_endocrine/exocrine_gland_phen	1.47966052
31	MP0003635_abnormal_synaptic_transmissio	1.47228332
32	MP0002184_abnormal_innervation	1.43031087
33	MP0002909_abnormal_adrenal_gland	1.42365669
34	MP0003186_abnormal_redox_activity	1.42040438
35	MP0004130_abnormal_muscle_cell	1.41684262
36	MP0004885_abnormal_endolymph	1.40635073
37	MP0005645_abnormal_hypothalamus_physiol	1.38976830
38	MP0009745_abnormal_behavioral_response	1.36455893
39	MP0002752_abnormal_somatic_nervous	1.32415721
40	MP0002160_abnormal_reproductive_system	1.32024917
41	MP0001986_abnormal_taste_sensitivity	1.31199374
42	MP0002272_abnormal_nervous_system	1.29121303
43	MP0005551_abnormal_eye_electrophysiolog	1.28976288
44	MP0002557_abnormal_social/conspecific_i	1.26794506
45	MP0006036_abnormal_mitochondrial_physio	1.25407010
46	MP0001968_abnormal_touch/_nociception	1.20742000
47	MP0000631_abnormal_neuroendocrine_gland	1.20174923
48	MP0001188_hyperpigmentation	1.19735619
49	MP0002733_abnormal_thermal_nociception	1.19598201
50	MP0002734_abnormal_mechanical_nocicepti	1.17931312
51	MP0002882_abnormal_neuron_morphology	1.16717402
52	MP0001485_abnormal_pinna_reflex	1.11167331
53	MP0002138_abnormal_hepatobiliary_system	1.10009931
54	MP0002572_abnormal_emotion/affect_behav	1.09766592
55	MP0000678_abnormal_parathyroid_gland	1.09577313
56	MP0005195_abnormal_posterior_eye	1.09574985
57	MP0001970_abnormal_pain_threshold	1.08067038
58	MP0005389_reproductive_system_phenotype	1.07086651
59	MP0002063_abnormal_learning/memory/cond	1.05653147
60	MP0000750_abnormal_muscle_regeneration	1.04589862
61	MP0001529_abnormal_vocalization	1.04074231
62	MP0002067_abnormal_sensory_capabilities	1.02762702
63	MP0003890_abnormal_embryonic-extraembry	1.00584808
64	MP0003942_abnormal_urinary_system	0.98321635
65	MP0000026_abnormal_inner_ear	0.97526452
66	MP0009053_abnormal_anal_canal	0.96788837
67	MP0001919_abnormal_reproductive_system	0.93873785
68	MP0001963_abnormal_hearing_physiology	0.93400896
69	MP0002938_white_spotting	0.92213879
70	MP0002064_seizures	0.91622211
71	MP0001664_abnormal_digestion	0.91290786
72	MP0009046_muscle_twitch	0.91046491
73	MP0002152_abnormal_brain_morphology	0.90647764
74	MP0003119_abnormal_digestive_system	0.89045020
75	MP0001293_anophthalmia	0.88721353
76	MP0001727_abnormal_embryo_implantation	0.87856049
77	MP0008775_abnormal_heart_ventricle	0.87099044
78	MP0004811_abnormal_neuron_physiology	0.86239594
79	MP0003315_abnormal_perineum_morphology	0.85923952
80	MP0003878_abnormal_ear_physiology	0.85155600
81	MP0005377_hearing/vestibular/ear_phenot	0.85155600
82	MP0008875_abnormal_xenobiotic_pharmacok	0.83129902
83	MP0004147_increased_porphyrin_level	0.82615315
84	MP0002735_abnormal_chemical_nociception	0.80514609
85	MP0005386_behavior/neurological_phenoty	0.80357508
86	MP0004924_abnormal_behavior	0.80357508
87	MP0001663_abnormal_digestive_system	0.79738514
88	MP0004133_heterotaxia	0.79617065
89	MP0001440_abnormal_grooming_behavior	0.78316805
90	MP0003646_muscle_fatigue	0.77413922
91	MP0002229_neurodegeneration	0.77166200
92	MP0008995_early_reproductive_senescence	0.74535471
93	MP0003861_abnormal_nervous_system	0.73347121
94	MP0003698_abnormal_male_reproductive	0.72426110
95	MP0003938_abnormal_ear_development	0.71756962
96	MP0002210_abnormal_sex_determination	0.71543675
97	MP0005332_abnormal_amino_acid	0.71538924
98	MP0009250_abnormal_appendicular_skeleto	0.70517774
99	MP0002736_abnormal_nociception_after	0.68019899
100	MP0002837_dystrophic_cardiac_calcinosis	0.67239078

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	9.86223841
2	Macrocytic anemia (HP:0001972)	5.43911796
3	Abnormal hemoglobin (HP:0011902)	5.16502463
4	Abnormality of cells of the erythroid lineage (HP:0012130)	5.06010319
5	Hyperglycinemia (HP:0002154)	4.94153867
6	Acute encephalopathy (HP:0006846)	4.42499955
7	Acute necrotizing encephalopathy (HP:0006965)	4.41104628
8	Pallor (HP:0000980)	4.38408596
9	Myokymia (HP:0002411)	4.28478515
10	Abnormality of alanine metabolism (HP:0010916)	4.21329994
11	Hyperalaninemia (HP:0003348)	4.21329994
12	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.21329994
13	Abnormal mitochondria in muscle tissue (HP:0008316)	3.98389065
14	Absent/shortened dynein arms (HP:0200106)	3.92304681
15	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.92304681
16	3-Methylglutaconic aciduria (HP:0003535)	3.83313719
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.76525419
18	Progressive macrocephaly (HP:0004481)	3.57512854
19	Abnormal number of erythroid precursors (HP:0012131)	3.48484650
20	Stenosis of the external auditory canal (HP:0000402)	3.31743494
21	Cerebral edema (HP:0002181)	3.29574465
22	Mitochondrial inheritance (HP:0001427)	3.28781472
23	Abnormality of midbrain morphology (HP:0002418)	3.07487457
24	Molar tooth sign on MRI (HP:0002419)	3.07487457
25	Abnormality of reticulocytes (HP:0004312)	3.07402903
26	Agitation (HP:0000713)	3.05203976
27	Increased CSF lactate (HP:0002490)	2.99557104
28	Abnormal ciliary motility (HP:0012262)	2.94758405
29	Abnormal respiratory motile cilium morphology (HP:0005938)	2.87397574
30	Abnormal respiratory epithelium morphology (HP:0012253)	2.87397574
31	Polyphagia (HP:0002591)	2.77424213
32	Respiratory difficulties (HP:0002880)	2.75784732
33	Abnormal respiratory motile cilium physiology (HP:0012261)	2.72883294
34	Progressive muscle weakness (HP:0003323)	2.72629106
35	Depressed nasal ridge (HP:0000457)	2.71535147
36	Hyperthyroidism (HP:0000836)	2.65611934
37	Abnormality of serine family amino acid metabolism (HP:0010894)	2.61803825
38	Abnormality of glycine metabolism (HP:0010895)	2.61803825
39	Abnormality of serum amino acid levels (HP:0003112)	2.60344176
40	Septo-optic dysplasia (HP:0100842)	2.59515434
41	Pancreatic fibrosis (HP:0100732)	2.57711624
42	Renal Fanconi syndrome (HP:0001994)	2.48181925
43	Fetal akinesia sequence (HP:0001989)	2.47692208
44	Increased serum lactate (HP:0002151)	2.36884360
45	Abnormal rod and cone electroretinograms (HP:0008323)	2.35737453
46	Oligodactyly (hands) (HP:0001180)	2.35058871
47	Lactic acidosis (HP:0003128)	2.31672765
48	Lethargy (HP:0001254)	2.30635989
49	Pendular nystagmus (HP:0012043)	2.30040550
50	Microvesicular hepatic steatosis (HP:0001414)	2.27951416
51	Lipid accumulation in hepatocytes (HP:0006561)	2.26810673
52	Calcaneovalgus deformity (HP:0001848)	2.23495203
53	Hyperglycinuria (HP:0003108)	2.20034508
54	Hepatocellular necrosis (HP:0001404)	2.19547422
55	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.19334766
56	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.18164362
57	Abnormality of the aortic arch (HP:0012303)	2.14011478
58	Poor suck (HP:0002033)	2.11089948
59	X-linked dominant inheritance (HP:0001423)	2.10131274
60	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.08142511
61	Optic disc pallor (HP:0000543)	2.07221184
62	Asplenia (HP:0001746)	2.06412308
63	Hepatic necrosis (HP:0002605)	2.06182255
64	Myotonia (HP:0002486)	2.05507909
65	Thick lower lip vermilion (HP:0000179)	2.04988964
66	Increased hepatocellular lipid droplets (HP:0006565)	2.04644556
67	Deformed tarsal bones (HP:0008119)	2.03943493
68	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.03256152
69	Exercise intolerance (HP:0003546)	1.99951720
70	Hypoplasia of the thymus (HP:0000778)	1.99948736
71	Migraine (HP:0002076)	1.99170281
72	Type II lissencephaly (HP:0007260)	1.95916015
73	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.95863791
74	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.95863791
75	Increased intramyocellular lipid droplets (HP:0012240)	1.93341853
76	Anomalous pulmonary venous return (HP:0010772)	1.91911052
77	Leukodystrophy (HP:0002415)	1.86943417
78	Testicular atrophy (HP:0000029)	1.84323469
79	Abnormal eating behavior (HP:0100738)	1.81144788
80	Increased muscle lipid content (HP:0009058)	1.80563803
81	Abnormal number of incisors (HP:0011064)	1.80423475
82	Increased serum pyruvate (HP:0003542)	1.78684602
83	Colon cancer (HP:0003003)	1.78662392
84	Bony spicule pigmentary retinopathy (HP:0007737)	1.77106063
85	Microretrognathia (HP:0000308)	1.76528465
86	Neonatal onset (HP:0003623)	1.75322706
87	Restlessness (HP:0000711)	1.75032317
88	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.71645050
89	Abnormality of renal resorption (HP:0011038)	1.71439069
90	Decreased central vision (HP:0007663)	1.70444881
91	Renal duplication (HP:0000075)	1.68869072
92	Infertility (HP:0000789)	1.68008356
93	Zonular cataract (HP:0010920)	1.63353515
94	Absent thumb (HP:0009777)	1.62339404
95	Esotropia (HP:0000565)	1.60855236
96	Menstrual irregularities (HP:0000858)	1.60232943
97	Impulsivity (HP:0100710)	1.60134511
98	Respiratory failure (HP:0002878)	1.59399786
99	Abnormality of the pulmonary veins (HP:0011718)	1.59377663
100	Prolonged neonatal jaundice (HP:0006579)	1.59302062

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	8.05748257
2	PDK2	6.49475604
3	TLK1	4.48494518
4	STK16	4.44157509
5	CDK19	2.96589365
6	VRK2	2.30617112
7	DYRK2	1.84588920
8	ABL2	1.62982979
9	MARK1	1.60874432
10	ADRBK2	1.56976259
11	PRKD3	1.56268592
12	BCKDK	1.53357463
13	ICK	1.46883563
14	PINK1	1.38377296
15	EPHB2	1.30559074
16	CSNK1G3	1.26912715
17	TAF1	1.23632816
18	NUAK1	1.19987850
19	GRK5	1.18610760
20	WNK3	1.15805588
21	CSNK1G2	1.13290124
22	CSNK1A1L	1.08852354
23	NEK2	1.03965446
24	STK11	0.99162772
25	ILK	0.94368174
26	PRKCG	0.94207296
27	PRKCI	0.93688512
28	AURKA	0.92298386
29	TNIK	0.91851682
30	SGK494	0.90793054
31	SGK223	0.90793054
32	MAP3K11	0.90469289
33	CSNK1G1	0.90460247
34	STK38	0.87282879
35	UHMK1	0.86318073
36	PRKCZ	0.85362749
37	DAPK3	0.83627844
38	CASK	0.80573184
39	FRK	0.77614117
40	MAP3K4	0.76393323
41	PDPK1	0.75867287
42	MAP2K4	0.74282362
43	MAP2K7	0.73443791
44	CHEK2	0.72251502
45	MAPK13	0.69287238
46	WNK4	0.68312975
47	CSNK1E	0.65156510
48	SGK2	0.63001115
49	PHKG1	0.60909536
50	PHKG2	0.60909536
51	LIMK1	0.59847387
52	CDK7	0.59675129
53	MAPK12	0.58482001
54	EPHA4	0.57229367
55	OXSR1	0.56266943
56	ZAK	0.54818768
57	GRK1	0.54561583
58	VRK1	0.53732736
59	JAK3	0.52605118
60	PRKD2	0.51903607
61	PRKCH	0.51326405
62	TYRO3	0.50534509
63	CAMK1	0.48313276
64	ADRBK1	0.47006335
65	TRIM28	0.46892470
66	EEF2K	0.45467187
67	CSNK2A2	0.44760873
68	MAPK15	0.44277524
69	MINK1	0.43226435
70	SGK3	0.43046155
71	NTRK2	0.41938399
72	CDC7	0.41658584
73	PRKACA	0.41555330
74	PRKCD	0.41082410
75	PRKCA	0.40564028
76	WEE1	0.40457531
77	LRRK2	0.40301795
78	DAPK2	0.38393548
79	KIT	0.37808240
80	SGK1	0.37293136
81	SMG1	0.36998486
82	PRKG2	0.36964488
83	CSNK1A1	0.35508842
84	CDK14	0.35298943
85	MARK2	0.34129481
86	CDK5	0.33642411
87	CAMK1D	0.33314131
88	ATR	0.32534827
89	DAPK1	0.32521075
90	RPS6KA2	0.30819895
91	CDK11A	0.30544313
92	PAK3	0.30278138
93	PRKG1	0.30164180
94	CDK2	0.29746172
95	MAP2K3	0.29574182
96	CAMK4	0.29467594
97	RPS6KA3	0.28873247
98	PAK1	0.27891072
99	MAPK8	0.27364655
100	INSRR	0.27228976

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.82558398
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.62617287
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	4.53834922
4	Parkinsons disease_Homo sapiens_hsa05012	3.70622463
5	Cardiac muscle contraction_Homo sapiens_hsa04260	3.17891170
6	Alzheimers disease_Homo sapiens_hsa05010	2.74545729
7	Huntingtons disease_Homo sapiens_hsa05016	2.53670448
8	Sulfur relay system_Homo sapiens_hsa04122	2.32953855
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.28918927
10	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.11655070
11	Fatty acid degradation_Homo sapiens_hsa00071	2.04399460
12	Basal cell carcinoma_Homo sapiens_hsa05217	1.99681998
13	Pyruvate metabolism_Homo sapiens_hsa00620	1.87019943
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.74777148
15	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.55450092
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.52463018
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.46518730
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.45551497
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.39529080
20	RNA polymerase_Homo sapiens_hsa03020	1.32893666
21	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.26968684
22	Arginine and proline metabolism_Homo sapiens_hsa00330	1.26883944
23	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.22958215
24	Fat digestion and absorption_Homo sapiens_hsa04975	1.18172736
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.14966129
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.09233304
27	beta-Alanine metabolism_Homo sapiens_hsa00410	1.06671514
28	Propanoate metabolism_Homo sapiens_hsa00640	1.06588573
29	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.05918457
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.02965292
31	Morphine addiction_Homo sapiens_hsa05032	0.99896023
32	Folate biosynthesis_Homo sapiens_hsa00790	0.94275347
33	Tryptophan metabolism_Homo sapiens_hsa00380	0.94017056
34	RNA degradation_Homo sapiens_hsa03018	0.93546835
35	Nicotine addiction_Homo sapiens_hsa05033	0.86205702
36	Peroxisome_Homo sapiens_hsa04146	0.82882947
37	Metabolic pathways_Homo sapiens_hsa01100	0.81492295
38	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.80928486
39	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.80626720
40	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.79959279
41	Phenylalanine metabolism_Homo sapiens_hsa00360	0.75672704
42	Steroid biosynthesis_Homo sapiens_hsa00100	0.72094115
43	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.70988270
44	Homologous recombination_Homo sapiens_hsa03440	0.70016360
45	Fatty acid metabolism_Homo sapiens_hsa01212	0.67826498
46	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.67694820
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.66777107
48	Glycerolipid metabolism_Homo sapiens_hsa00561	0.66607414
49	Butanoate metabolism_Homo sapiens_hsa00650	0.63178076
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62577656
51	Melanogenesis_Homo sapiens_hsa04916	0.59684401
52	Caffeine metabolism_Homo sapiens_hsa00232	0.58538114
53	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.57566496
54	Sulfur metabolism_Homo sapiens_hsa00920	0.57345465
55	GABAergic synapse_Homo sapiens_hsa04727	0.54241590
56	Purine metabolism_Homo sapiens_hsa00230	0.52797265
57	Hippo signaling pathway_Homo sapiens_hsa04390	0.52492949
58	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.52395161
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.52129760
60	Insulin secretion_Homo sapiens_hsa04911	0.51139642
61	Phototransduction_Homo sapiens_hsa04744	0.50991567
62	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.50255725
63	Wnt signaling pathway_Homo sapiens_hsa04310	0.49688398
64	Fatty acid elongation_Homo sapiens_hsa00062	0.49066269
65	Olfactory transduction_Homo sapiens_hsa04740	0.48672562
66	DNA replication_Homo sapiens_hsa03030	0.47562713
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.47183809
68	Basal transcription factors_Homo sapiens_hsa03022	0.46093751
69	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.45234082
70	Fanconi anemia pathway_Homo sapiens_hsa03460	0.45031463
71	Galactose metabolism_Homo sapiens_hsa00052	0.44221392
72	Pentose phosphate pathway_Homo sapiens_hsa00030	0.43184054
73	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.42915313
74	Retinol metabolism_Homo sapiens_hsa00830	0.42348832
75	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.41430913
76	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.40450368
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.39276403
78	Tyrosine metabolism_Homo sapiens_hsa00350	0.38927556
79	Axon guidance_Homo sapiens_hsa04360	0.35092710
80	Histidine metabolism_Homo sapiens_hsa00340	0.33694597
81	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.33494114
82	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.32919985
83	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.32316482
84	Nucleotide excision repair_Homo sapiens_hsa03420	0.31910196
85	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.31897835
86	Regulation of autophagy_Homo sapiens_hsa04140	0.29677937
87	Arginine biosynthesis_Homo sapiens_hsa00220	0.28938059
88	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.28916913
89	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.27226067
90	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.26972324
91	RNA transport_Homo sapiens_hsa03013	0.26788396
92	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.26035943
93	Chemical carcinogenesis_Homo sapiens_hsa05204	0.25664858
94	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.24925754
95	Glutamatergic synapse_Homo sapiens_hsa04724	0.24623801
96	Mismatch repair_Homo sapiens_hsa03430	0.23971898
97	Serotonergic synapse_Homo sapiens_hsa04726	0.23773700
98	Circadian entrainment_Homo sapiens_hsa04713	0.23194537
99	Spliceosome_Homo sapiens_hsa03040	0.21739449
100	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.21565698

RPS24P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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