RPS24P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)9.31053778
2viral transcription (GO:0019083)7.74841147
3ribosomal small subunit biogenesis (GO:0042274)7.52696917
4translational termination (GO:0006415)7.41001993
5maturation of SSU-rRNA (GO:0030490)7.19521655
6translational elongation (GO:0006414)6.38998069
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.33106504
8cotranslational protein targeting to membrane (GO:0006613)6.21740960
9protein targeting to ER (GO:0045047)6.21307385
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.90615037
11protein localization to endoplasmic reticulum (GO:0070972)5.86853050
12DNA deamination (GO:0045006)5.77901338
13viral life cycle (GO:0019058)5.61374496
14cellular protein complex disassembly (GO:0043624)5.59981532
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.43767742
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.41203927
17cytidine metabolic process (GO:0046087)5.25117670
18cytidine catabolic process (GO:0006216)5.25117670
19cytidine deamination (GO:0009972)5.25117670
20ATP synthesis coupled proton transport (GO:0015986)5.04322734
21energy coupled proton transport, down electrochemical gradient (GO:0015985)5.04322734
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.94975337
23translational initiation (GO:0006413)4.89961226
24protein complex disassembly (GO:0043241)4.63682781
25protein neddylation (GO:0045116)4.52788384
26macromolecular complex disassembly (GO:0032984)4.39421587
27ribosomal large subunit biogenesis (GO:0042273)4.38289631
28pyrimidine ribonucleoside catabolic process (GO:0046133)4.35469474
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.35390781
30behavioral response to nicotine (GO:0035095)4.27342589
31chaperone-mediated protein transport (GO:0072321)4.19582330
32translation (GO:0006412)4.19285245
33protein targeting to membrane (GO:0006612)4.10300609
34respiratory electron transport chain (GO:0022904)4.04485033
35electron transport chain (GO:0022900)3.99204863
36cornea development in camera-type eye (GO:0061303)3.79727950
37nuclear-transcribed mRNA catabolic process (GO:0000956)3.74576174
38pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.71913965
39tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.60086246
40RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.60086246
41protein complex biogenesis (GO:0070271)3.58344589
42ribonucleoprotein complex biogenesis (GO:0022613)3.57316566
43metallo-sulfur cluster assembly (GO:0031163)3.51065463
44iron-sulfur cluster assembly (GO:0016226)3.51065463
45mRNA catabolic process (GO:0006402)3.49767634
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.46568379
47cellular component biogenesis (GO:0044085)3.40999627
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40455995
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.40455995
50NADH dehydrogenase complex assembly (GO:0010257)3.40455995
51water-soluble vitamin biosynthetic process (GO:0042364)3.28511910
52axoneme assembly (GO:0035082)3.28415617
53sequestering of actin monomers (GO:0042989)3.18403952
54negative regulation by host of viral transcription (GO:0043922)3.15670483
55mitochondrial respiratory chain complex assembly (GO:0033108)3.15636384
56ncRNA 3-end processing (GO:0043628)3.14957789
57RNA catabolic process (GO:0006401)3.13137512
58positive regulation of T cell apoptotic process (GO:0070234)3.12835001
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94630118
60pyrimidine nucleotide catabolic process (GO:0006244)2.89327493
61ATP biosynthetic process (GO:0006754)2.88693298
62base-excision repair, AP site formation (GO:0006285)2.83914317
63exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79021811
64purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.74422570
65cell proliferation in forebrain (GO:0021846)2.72303920
66establishment of protein localization to membrane (GO:0090150)2.72043175
67mast cell degranulation (GO:0043303)2.71930125
68mast cell activation involved in immune response (GO:0002279)2.71930125
69platelet dense granule organization (GO:0060155)2.71677946
70purine nucleoside triphosphate biosynthetic process (GO:0009145)2.71101648
71proteasome assembly (GO:0043248)2.67821854
72protein targeting (GO:0006605)2.67618299
73hydrogen ion transmembrane transport (GO:1902600)2.66947662
74deoxyribonucleotide catabolic process (GO:0009264)2.65846385
75regulation of activation of Janus kinase activity (GO:0010533)2.65538892
76pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.64211606
77deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.58676087
78rRNA processing (GO:0006364)2.56429746
79GPI anchor metabolic process (GO:0006505)2.51714244
80rRNA metabolic process (GO:0016072)2.51568887
81deoxyribose phosphate catabolic process (GO:0046386)2.50281654
82substrate-independent telencephalic tangential migration (GO:0021826)2.50081177
83substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.50081177
84male meiosis I (GO:0007141)2.49100622
85negative regulation of T cell differentiation in thymus (GO:0033085)2.48437045
86positive regulation of respiratory burst (GO:0060267)2.47312075
87DNA demethylation (GO:0080111)2.44665906
88establishment of protein localization to organelle (GO:0072594)2.43509094
89proton transport (GO:0015992)2.43302344
90cytolysis (GO:0019835)2.43046469
91pseudouridine synthesis (GO:0001522)2.41766050
92positive regulation of defense response to virus by host (GO:0002230)2.40913934
93positive regulation of calcium-mediated signaling (GO:0050850)2.40760284
94protein targeting to mitochondrion (GO:0006626)2.39568218
95regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.38885227
96transcription elongation from RNA polymerase III promoter (GO:0006385)2.38391238
97termination of RNA polymerase III transcription (GO:0006386)2.38391238
98GPI anchor biosynthetic process (GO:0006506)2.37933070
99nonmotile primary cilium assembly (GO:0035058)2.36762535
100forebrain morphogenesis (GO:0048853)2.36545010

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.73931267
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.53106161
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.46888466
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.37719881
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.30670661
6VDR_22108803_ChIP-Seq_LS180_Human2.84513818
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.76264019
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51572638
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45216646
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.42850407
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.32655863
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.25546641
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.22976540
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.16912353
15ZNF274_21170338_ChIP-Seq_K562_Hela1.98582866
16VDR_23849224_ChIP-Seq_CD4+_Human1.94473058
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.92045555
18IGF1R_20145208_ChIP-Seq_DFB_Human1.87563948
19MYC_18555785_ChIP-Seq_MESCs_Mouse1.77620165
20MYC_18940864_ChIP-ChIP_HL60_Human1.74763130
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.71777070
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69892426
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68107214
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67275847
25CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.60955471
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58133097
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.55586678
28TP53_22573176_ChIP-Seq_HFKS_Human1.53402008
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49832013
30FOXP3_21729870_ChIP-Seq_TREG_Human1.49076597
31NANOG_20526341_ChIP-Seq_ESCs_Human1.48310548
32CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.46851773
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42999349
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.42701602
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40360549
36RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.38559075
37TAF2_19829295_ChIP-Seq_ESCs_Human1.37023996
38ELK1_19687146_ChIP-ChIP_HELA_Human1.36279907
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35550256
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.34837813
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34723653
42EWS_26573619_Chip-Seq_HEK293_Human1.32344368
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29631055
44AR_20517297_ChIP-Seq_VCAP_Human1.28973329
45EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.28748969
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27239806
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27101978
48NCOR_22424771_ChIP-Seq_293T_Human1.25237345
49AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25159527
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.23605472
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.23327560
52TTF2_22483619_ChIP-Seq_HELA_Human1.23121165
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22885200
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22742745
55BCL6_27268052_Chip-Seq_Bcells_Human1.22568263
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22035532
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.21610062
58RNF2_27304074_Chip-Seq_NSC_Mouse1.21298568
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21123848
60MYC_19829295_ChIP-Seq_ESCs_Human1.19086372
61CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16869781
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14710366
63HTT_18923047_ChIP-ChIP_STHdh_Human1.14623758
64FUS_26573619_Chip-Seq_HEK293_Human1.13707787
65YY1_22570637_ChIP-Seq_MALME-3M_Human1.13422798
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.13344823
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13280823
68IRF1_19129219_ChIP-ChIP_H3396_Human1.13230447
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.12829116
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12829116
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.11449303
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10655653
73EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.10433588
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10124622
75ERA_21632823_ChIP-Seq_H3396_Human1.09707364
76TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08617669
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08586232
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.08373848
79PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07949541
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06723822
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.06351100
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02642321
83P300_19829295_ChIP-Seq_ESCs_Human1.01596549
84P53_21459846_ChIP-Seq_SAOS-2_Human0.99942811
85NANOG_19829295_ChIP-Seq_ESCs_Human0.99022035
86SOX2_19829295_ChIP-Seq_ESCs_Human0.99022035
87GATA6_21074721_ChIP-Seq_CACO-2_Human0.97213623
88XRN2_22483619_ChIP-Seq_HELA_Human0.96780775
89CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95047505
90ERG_20517297_ChIP-Seq_VCAP_Human0.95047181
91RBPJ_21746931_ChIP-Seq_IB4_Human0.94729757
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94025186
93TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93529682
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92745038
95CTCF_20526341_ChIP-Seq_ESCs_Human0.92014356
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91264315
97PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90540592
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88907473
99PHF8_20622853_ChIP-Seq_HELA_Human0.88864754
100CBP_20019798_ChIP-Seq_JUKART_Human0.88701712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.32430957
2MP0006292_abnormal_olfactory_placode5.24012256
3MP0005671_abnormal_response_to2.68876502
4MP0008789_abnormal_olfactory_epithelium2.60581732
5MP0002163_abnormal_gland_morphology2.34214984
6MP0003646_muscle_fatigue2.23264271
7MP0003787_abnormal_imprinting2.22763893
8MP0008877_abnormal_DNA_methylation2.03835197
9MP0002638_abnormal_pupillary_reflex1.94232607
10MP0005646_abnormal_pituitary_gland1.92302970
11MP0005645_abnormal_hypothalamus_physiol1.92234222
12MP0005499_abnormal_olfactory_system1.87110597
13MP0005394_taste/olfaction_phenotype1.87110597
14MP0003878_abnormal_ear_physiology1.79357496
15MP0005377_hearing/vestibular/ear_phenot1.79357496
16MP0000049_abnormal_middle_ear1.72863766
17MP0002653_abnormal_ependyma_morphology1.63690365
18MP0002837_dystrophic_cardiac_calcinosis1.61574072
19MP0005389_reproductive_system_phenotype1.57689755
20MP0002160_abnormal_reproductive_system1.57504288
21MP0001485_abnormal_pinna_reflex1.56582313
22MP0001873_stomach_inflammation1.54982815
23MP0005084_abnormal_gallbladder_morpholo1.54860442
24MP0004147_increased_porphyrin_level1.52223557
25MP0002102_abnormal_ear_morphology1.49344200
26MP0004885_abnormal_endolymph1.46457981
27MP0002234_abnormal_pharynx_morphology1.46048774
28MP0009333_abnormal_splenocyte_physiolog1.45733514
29MP0003880_abnormal_central_pattern1.45276482
30MP0008872_abnormal_physiological_respon1.43546280
31MP0004142_abnormal_muscle_tone1.42982575
32MP0005379_endocrine/exocrine_gland_phen1.42962147
33MP0001919_abnormal_reproductive_system1.42731010
34MP0005551_abnormal_eye_electrophysiolog1.41691025
35MP0000372_irregular_coat_pigmentation1.41690225
36MP0003136_yellow_coat_color1.40380228
37MP0002876_abnormal_thyroid_physiology1.39940175
38MP0006072_abnormal_retinal_apoptosis1.37712920
39MP0006276_abnormal_autonomic_nervous1.36308958
40MP0000678_abnormal_parathyroid_gland1.33231372
41MP0000631_abnormal_neuroendocrine_gland1.30308436
42MP0001968_abnormal_touch/_nociception1.29749069
43MP0009785_altered_susceptibility_to1.27193106
44MP0001293_anophthalmia1.26731897
45MP0003763_abnormal_thymus_physiology1.25491363
46MP0001905_abnormal_dopamine_level1.24415704
47MP0003567_abnormal_fetal_cardiomyocyte1.23104931
48MP0002095_abnormal_skin_pigmentation1.20278713
49MP0002138_abnormal_hepatobiliary_system1.17441013
50MP0002736_abnormal_nociception_after1.15800508
51MP0003123_paternal_imprinting1.15147878
52MP0008995_early_reproductive_senescence1.12039827
53MP0002277_abnormal_respiratory_mucosa1.11220834
54MP0003122_maternal_imprinting1.09424105
55MP0008875_abnormal_xenobiotic_pharmacok1.06125269
56MP0004145_abnormal_muscle_electrophysio1.05880569
57MP0002132_abnormal_respiratory_system1.05049114
58MP0004742_abnormal_vestibular_system1.01946198
59MP0001188_hyperpigmentation1.01840744
60MP0003938_abnormal_ear_development1.01797739
61MP0005083_abnormal_biliary_tract1.00958288
62MP0001764_abnormal_homeostasis1.00320011
63MP0009745_abnormal_behavioral_response0.97947046
64MP0003121_genomic_imprinting0.97117757
65MP0002148_abnormal_hypersensitivity_rea0.95440798
66MP0001800_abnormal_humoral_immune0.94984857
67MP0001529_abnormal_vocalization0.94876874
68MP0001986_abnormal_taste_sensitivity0.94701462
69MP0005257_abnormal_intraocular_pressure0.89646591
70MP0003786_premature_aging0.88968560
71MP0002272_abnormal_nervous_system0.86654252
72MP0005025_abnormal_response_to0.86084666
73MP0002733_abnormal_thermal_nociception0.85849168
74MP0005195_abnormal_posterior_eye0.85848501
75MP0005000_abnormal_immune_tolerance0.84475680
76MP0000026_abnormal_inner_ear0.82342669
77MP0002723_abnormal_immune_serum0.81424345
78MP0002735_abnormal_chemical_nociception0.80709374
79MP0005253_abnormal_eye_physiology0.80219554
80MP0002938_white_spotting0.80091648
81MP0002420_abnormal_adaptive_immunity0.79452571
82MP0005387_immune_system_phenotype0.79016743
83MP0001790_abnormal_immune_system0.79016743
84MP0001963_abnormal_hearing_physiology0.78870556
85MP0001819_abnormal_immune_cell0.77143247
86MP0004133_heterotaxia0.76239050
87MP0001835_abnormal_antigen_presentation0.75362791
88MP0001970_abnormal_pain_threshold0.74467870
89MP0005174_abnormal_tail_pigmentation0.74362863
90MP0001348_abnormal_lacrimal_gland0.72927106
91MP0002210_abnormal_sex_determination0.72426486
92MP0000613_abnormal_salivary_gland0.71432128
93MP0002752_abnormal_somatic_nervous0.71311085
94MP0003866_abnormal_defecation0.71043285
95MP0003186_abnormal_redox_activity0.70197580
96MP0002822_catalepsy0.66797973
97MP0005410_abnormal_fertilization0.66643510
98MP0003283_abnormal_digestive_organ0.66442858
99MP0000716_abnormal_immune_system0.66424391
100MP0001663_abnormal_digestive_system0.64678900

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.34125194
2Abnormality of cells of the erythroid lineage (HP:0012130)4.68169372
3Acute necrotizing encephalopathy (HP:0006965)4.23262067
4Mitochondrial inheritance (HP:0001427)4.04761967
5Absent rod-and cone-mediated responses on ERG (HP:0007688)3.98733815
6Macrocytic anemia (HP:0001972)3.87304829
7Abnormal number of erythroid precursors (HP:0012131)3.86039694
8Increased intramyocellular lipid droplets (HP:0012240)3.85443253
9Abnormal mitochondria in muscle tissue (HP:0008316)3.84518134
10Increased hepatocellular lipid droplets (HP:0006565)3.77095166
11Pallor (HP:0000980)3.62302778
12Acute encephalopathy (HP:0006846)3.57035868
13Increased CSF lactate (HP:0002490)3.41462990
14Lipid accumulation in hepatocytes (HP:0006561)3.37022446
15Progressive macrocephaly (HP:0004481)3.35754078
16Increased muscle lipid content (HP:0009058)3.24232084
17Congenital stationary night blindness (HP:0007642)3.16779989
183-Methylglutaconic aciduria (HP:0003535)3.05587982
19Renal Fanconi syndrome (HP:0001994)3.05209860
20Cerebral edema (HP:0002181)3.04738334
21Abnormality of midbrain morphology (HP:0002418)3.01776510
22Molar tooth sign on MRI (HP:0002419)3.01776510
23Hepatocellular necrosis (HP:0001404)2.96988599
24Abnormal rod and cone electroretinograms (HP:0008323)2.96846910
25Stenosis of the external auditory canal (HP:0000402)2.95393674
26Aplasia/Hypoplasia of the sacrum (HP:0008517)2.86789498
27Pancreatic cysts (HP:0001737)2.86755425
28Pancreatic fibrosis (HP:0100732)2.86262352
29True hermaphroditism (HP:0010459)2.72522089
30Aplastic anemia (HP:0001915)2.72314184
31Septo-optic dysplasia (HP:0100842)2.71529538
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.70774234
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.70774234
34Abnormal hemoglobin (HP:0011902)2.67672471
35Absent thumb (HP:0009777)2.65623454
36Hepatic necrosis (HP:0002605)2.62336371
37Optic disc pallor (HP:0000543)2.55035788
38Abnormal ciliary motility (HP:0012262)2.49745561
39Exertional dyspnea (HP:0002875)2.49115674
40Methylmalonic acidemia (HP:0002912)2.46592527
41Pendular nystagmus (HP:0012043)2.45909156
42Hyperglycinemia (HP:0002154)2.39720758
43Abnormality of B cell number (HP:0010975)2.31853130
44Severe combined immunodeficiency (HP:0004430)2.31651648
45Abnormal respiratory epithelium morphology (HP:0012253)2.31248142
46Abnormal respiratory motile cilium morphology (HP:0005938)2.31248142
47Asplenia (HP:0001746)2.30902683
48Aplasia/Hypoplasia of the spleen (HP:0010451)2.30638898
49IgG deficiency (HP:0004315)2.30544602
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.29599802
51Abnormality of DNA repair (HP:0003254)2.27089911
52Abnormal respiratory motile cilium physiology (HP:0012261)2.24936342
53Elevated erythrocyte sedimentation rate (HP:0003565)2.22155798
54Decreased central vision (HP:0007663)2.20198021
55Abolished electroretinogram (ERG) (HP:0000550)2.19404335
56Methylmalonic aciduria (HP:0012120)2.19108920
57Increased serum lactate (HP:0002151)2.18423831
58Nephronophthisis (HP:0000090)2.18412970
59Lethargy (HP:0001254)2.15640843
60Medial flaring of the eyebrow (HP:0010747)2.15498621
61B lymphocytopenia (HP:0010976)2.15177005
62Rib fusion (HP:0000902)2.13591686
63Lactic acidosis (HP:0003128)2.11017657
64Abnormality of renal resorption (HP:0011038)2.10203250
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.06295251
66Respiratory difficulties (HP:0002880)2.04756905
67Attenuation of retinal blood vessels (HP:0007843)2.04606304
68Depressed nasal ridge (HP:0000457)2.00218875
69Exercise intolerance (HP:0003546)1.98759781
70Abnormality of the phalanges of the 5th finger (HP:0004213)1.97579730
71Abnormality of macular pigmentation (HP:0008002)1.97012934
72Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.96896844
73Maternal diabetes (HP:0009800)1.95301465
74Optic nerve hypoplasia (HP:0000609)1.92146615
75Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89793991
76Colon cancer (HP:0003003)1.89057785
77Sclerocornea (HP:0000647)1.88025770
78Abnormality of the renal collecting system (HP:0004742)1.87946814
79Triphalangeal thumb (HP:0001199)1.84984018
80Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80523478
81Hypoproteinemia (HP:0003075)1.80391600
82Respiratory failure (HP:0002878)1.79893632
83Glycosuria (HP:0003076)1.79726650
84Abnormality of urine glucose concentration (HP:0011016)1.79726650
85Abnormality of T cell number (HP:0011839)1.79718507
86Hypoplasia of the fovea (HP:0007750)1.79193881
87Aplasia/Hypoplasia of the fovea (HP:0008060)1.79193881
88Anencephaly (HP:0002323)1.78685322
89T lymphocytopenia (HP:0005403)1.78542482
90Ketosis (HP:0001946)1.77320219
91Abnormality of the fovea (HP:0000493)1.77194672
92Thyroiditis (HP:0100646)1.76854526
93Hyperphosphaturia (HP:0003109)1.74074643
94Type II lissencephaly (HP:0007260)1.73042353
95Pancytopenia (HP:0001876)1.73023747
96Abnormality of the renal cortex (HP:0011035)1.69542995
97Abnormality of the phalanges of the 2nd finger (HP:0009541)1.69050173
98Concave nail (HP:0001598)1.67739384
99Abnormality of the renal medulla (HP:0100957)1.67066867
100Combined immunodeficiency (HP:0005387)1.65471900

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.16234088
2KDR3.68595843
3TXK3.36440239
4CDK193.02442740
5ADRBK22.79852364
6VRK22.57295741
7WNK42.46768474
8TESK22.44101008
9GRK12.43756048
10STK162.36610098
11ZAK2.26455320
12TLK12.19850972
13PINK11.88204803
14MAP4K21.74412233
15TAOK31.69057950
16DYRK21.57072974
17NUAK11.49159449
18VRK11.42225674
19ITK1.41838573
20MAP3K111.25474928
21LIMK11.23682772
22WNK31.22411061
23MUSK1.19592006
24NME21.15206657
25PRKCQ1.13523078
26BUB11.12584278
27GRK71.11496020
28TIE11.10743000
29MAPK131.10499038
30MAP4K11.09708351
31TNK21.09037269
32PLK41.07218042
33PIK3CA1.04072371
34TEC1.02083328
35FRK1.01426978
36EPHB20.98239658
37BMPR1B0.97281122
38INSRR0.97016094
39ADRBK10.94282318
40LRRK20.93402670
41IKBKE0.92248474
42PASK0.89954224
43AURKA0.88040562
44STK390.84697418
45MAP3K40.84482169
46BTK0.84406135
47MAP2K70.84302907
48SYK0.82282440
49OBSCN0.81207154
50PIK3CG0.78940643
51TRIM280.77489585
52RPS6KA50.76332825
53KIT0.75644933
54CAMK10.74835304
55RPS6KA60.67243003
56NME10.66744511
57GRK60.66724442
58CSNK1G10.65311500
59ABL20.64682288
60EPHA40.63735320
61CDC70.63641676
62LCK0.61243888
63PRKACA0.60707767
64PRKCH0.59207804
65CSNK2A20.58964567
66CSNK1G20.57901123
67RPS6KA40.57800729
68NTRK20.57507276
69DAPK30.57318351
70CSNK1G30.56874537
71MAP2K60.56817959
72CSNK2A10.55240604
73DYRK1A0.54562487
74CAMKK20.52924078
75IKBKB0.50606732
76DAPK20.50479588
77PIM10.49848230
78RPS6KL10.49523636
79RPS6KC10.49523636
80PRKCG0.45934977
81RPS6KB20.45909773
82FES0.45553984
83EIF2AK30.45102725
84LYN0.45038551
85PRKCA0.44691116
86TESK10.43831630
87PLK20.43054304
88BRSK10.42550160
89OXSR10.42341622
90AURKB0.39180923
91PTK2B0.36808573
92PKN10.36078600
93CSNK1A10.35381996
94GRK50.35165004
95CAMK2A0.35008710
96PRKCD0.33077789
97CDK30.32989336
98TRPM70.31676051
99CSK0.29941549
100NEK20.29815339

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.70464397
2Oxidative phosphorylation_Homo sapiens_hsa001904.21889264
3Parkinsons disease_Homo sapiens_hsa050123.61283892
4Primary immunodeficiency_Homo sapiens_hsa053403.08222209
5Proteasome_Homo sapiens_hsa030502.73143140
6Huntingtons disease_Homo sapiens_hsa050162.46244244
7Alzheimers disease_Homo sapiens_hsa050102.44539920
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.38089344
9Cardiac muscle contraction_Homo sapiens_hsa042602.29055339
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05654758
11Allograft rejection_Homo sapiens_hsa053301.98202020
12Graft-versus-host disease_Homo sapiens_hsa053321.96501741
13RNA polymerase_Homo sapiens_hsa030201.95004171
14Autoimmune thyroid disease_Homo sapiens_hsa053201.92866325
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87497635
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77625986
17Asthma_Homo sapiens_hsa053101.65413528
18Phototransduction_Homo sapiens_hsa047441.56004453
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55548285
20Protein export_Homo sapiens_hsa030601.55185203
21Antigen processing and presentation_Homo sapiens_hsa046121.54510513
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.43114788
23Type I diabetes mellitus_Homo sapiens_hsa049401.42956115
24Linoleic acid metabolism_Homo sapiens_hsa005911.42767140
25Hematopoietic cell lineage_Homo sapiens_hsa046401.34353546
26RNA degradation_Homo sapiens_hsa030181.26397346
27Homologous recombination_Homo sapiens_hsa034401.24607801
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23001752
29Fanconi anemia pathway_Homo sapiens_hsa034601.20878154
30Sulfur relay system_Homo sapiens_hsa041221.16286354
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14418986
32Propanoate metabolism_Homo sapiens_hsa006401.09470623
33Butanoate metabolism_Homo sapiens_hsa006501.04816138
34Nitrogen metabolism_Homo sapiens_hsa009101.03472948
35Pyrimidine metabolism_Homo sapiens_hsa002401.03356442
36Peroxisome_Homo sapiens_hsa041460.98684859
37Olfactory transduction_Homo sapiens_hsa047400.97131023
38Retinol metabolism_Homo sapiens_hsa008300.95781111
39Steroid hormone biosynthesis_Homo sapiens_hsa001400.94715834
40Caffeine metabolism_Homo sapiens_hsa002320.92660374
41Chemical carcinogenesis_Homo sapiens_hsa052040.89543593
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89023489
43Nicotine addiction_Homo sapiens_hsa050330.85195375
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84063980
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83744941
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81508759
47Rheumatoid arthritis_Homo sapiens_hsa053230.81183442
48Nucleotide excision repair_Homo sapiens_hsa034200.80982286
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80720790
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79915892
51Basal transcription factors_Homo sapiens_hsa030220.79048479
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.78781687
53DNA replication_Homo sapiens_hsa030300.78106722
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77775535
55Tryptophan metabolism_Homo sapiens_hsa003800.77302773
56Base excision repair_Homo sapiens_hsa034100.77071361
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75100115
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71813083
59Arachidonic acid metabolism_Homo sapiens_hsa005900.70918576
60T cell receptor signaling pathway_Homo sapiens_hsa046600.70703637
61Purine metabolism_Homo sapiens_hsa002300.70377179
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66869487
63Spliceosome_Homo sapiens_hsa030400.66570867
64Systemic lupus erythematosus_Homo sapiens_hsa053220.65124881
65Malaria_Homo sapiens_hsa051440.62354499
66Fat digestion and absorption_Homo sapiens_hsa049750.60876533
67Mismatch repair_Homo sapiens_hsa034300.60291653
68Metabolic pathways_Homo sapiens_hsa011000.60152921
69Ether lipid metabolism_Homo sapiens_hsa005650.59444910
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57321506
71Taste transduction_Homo sapiens_hsa047420.56372860
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55998138
73Viral myocarditis_Homo sapiens_hsa054160.53388497
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50520247
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48778816
76Folate biosynthesis_Homo sapiens_hsa007900.43444031
77One carbon pool by folate_Homo sapiens_hsa006700.41498947
78Morphine addiction_Homo sapiens_hsa050320.39772165
79Basal cell carcinoma_Homo sapiens_hsa052170.38332625
80RNA transport_Homo sapiens_hsa030130.38304853
81Hedgehog signaling pathway_Homo sapiens_hsa043400.36384276
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.35069395
83Steroid biosynthesis_Homo sapiens_hsa001000.31438295
84Ovarian steroidogenesis_Homo sapiens_hsa049130.31054937
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30432547
86Sulfur metabolism_Homo sapiens_hsa009200.30223298
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.29544094
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28647669
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.26781051
90Serotonergic synapse_Homo sapiens_hsa047260.24313324
91Salivary secretion_Homo sapiens_hsa049700.23439774
92Measles_Homo sapiens_hsa051620.23293569
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21843340
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20230598
95African trypanosomiasis_Homo sapiens_hsa051430.20175322
96Tyrosine metabolism_Homo sapiens_hsa003500.17448254
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.17383048
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16817312
99Staphylococcus aureus infection_Homo sapiens_hsa051500.16325381
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.14759543

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