RPS25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S25E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* ribosomal small subunit assembly (GO:0000028)6.76125465
2* viral transcription (GO:0019083)6.50023726
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.32254973
4* translational termination (GO:0006415)6.30632104
5ribosomal small subunit biogenesis (GO:0042274)5.81748929
6energy coupled proton transport, down electrochemical gradient (GO:0015985)5.81096935
7ATP synthesis coupled proton transport (GO:0015986)5.81096935
8* translational elongation (GO:0006414)5.56264279
9maturation of SSU-rRNA (GO:0030490)5.53176525
10* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.48894733
11* protein targeting to ER (GO:0045047)5.34331724
12* cotranslational protein targeting to membrane (GO:0006613)5.33950086
13* establishment of protein localization to endoplasmic reticulum (GO:0072599)5.07435502
14* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.06769759
15* translational initiation (GO:0006413)5.03033621
16ribosomal large subunit biogenesis (GO:0042273)5.02128794
17* protein localization to endoplasmic reticulum (GO:0070972)5.00075167
18* viral life cycle (GO:0019058)4.87991110
19* cellular protein complex disassembly (GO:0043624)4.86689757
20respiratory electron transport chain (GO:0022904)4.45757021
21* establishment of protein localization to membrane (GO:0090150)4.38698047
22electron transport chain (GO:0022900)4.36034160
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.34400343
24* protein complex disassembly (GO:0043241)4.33191421
25ribonucleoprotein complex biogenesis (GO:0022613)4.22569564
26formation of translation preinitiation complex (GO:0001731)4.18955712
27DNA strand elongation involved in DNA replication (GO:0006271)4.13992602
28establishment of protein localization to mitochondrial membrane (GO:0090151)4.13619180
29DNA deamination (GO:0045006)4.12893865
30telomere maintenance via semi-conservative replication (GO:0032201)4.09636605
31* macromolecular complex disassembly (GO:0032984)4.07926777
32* protein targeting (GO:0006605)4.04498556
33* establishment of protein localization to organelle (GO:0072594)3.96668418
34DNA strand elongation (GO:0022616)3.94617202
35* nuclear-transcribed mRNA catabolic process (GO:0000956)3.88960129
36chaperone-mediated protein transport (GO:0072321)3.86216751
37* translation (GO:0006412)3.82898747
38DNA replication initiation (GO:0006270)3.70469408
39* mRNA catabolic process (GO:0006402)3.69819056
40telomere maintenance via recombination (GO:0000722)3.68517652
41oxidative phosphorylation (GO:0006119)3.66543019
42IMP biosynthetic process (GO:0006188)3.57828877
43* RNA catabolic process (GO:0006401)3.54002912
44DNA unwinding involved in DNA replication (GO:0006268)3.52684774
45regulation of mitochondrial translation (GO:0070129)3.49440693
46mitotic recombination (GO:0006312)3.49419628
47rRNA processing (GO:0006364)3.47788183
48DNA replication checkpoint (GO:0000076)3.46390458
49kinetochore organization (GO:0051383)3.46382035
50CENP-A containing nucleosome assembly (GO:0034080)3.45886024
51* protein targeting to membrane (GO:0006612)3.44036556
52* protein localization to membrane (GO:0072657)3.43398785
53chromatin remodeling at centromere (GO:0031055)3.40330903
54ribosome biogenesis (GO:0042254)3.36673199
55protein localization to kinetochore (GO:0034501)3.36384056
56rRNA metabolic process (GO:0016072)3.34814182
57nucleobase biosynthetic process (GO:0046112)3.31132849
58ATP biosynthetic process (GO:0006754)3.27447327
59telomere maintenance via telomere lengthening (GO:0010833)3.26040825
60inner mitochondrial membrane organization (GO:0007007)3.23636758
61mitotic metaphase plate congression (GO:0007080)3.21912485
62protein complex biogenesis (GO:0070271)3.20391017
63IMP metabolic process (GO:0046040)3.20376424
64mitochondrial respiratory chain complex I assembly (GO:0032981)3.17482589
65NADH dehydrogenase complex assembly (GO:0010257)3.17482589
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.17482589
67mitotic nuclear envelope disassembly (GO:0007077)3.16627750
68kinetochore assembly (GO:0051382)3.15715006
69folic acid-containing compound biosynthetic process (GO:0009396)3.13627718
70spliceosomal snRNP assembly (GO:0000387)3.13520184
71protein localization to chromosome, centromeric region (GO:0071459)3.13172943
72nucleotide-excision repair, DNA gap filling (GO:0006297)3.12470095
73mitochondrial respiratory chain complex assembly (GO:0033108)3.11914514
74purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.11510058
75purine nucleobase biosynthetic process (GO:0009113)3.10665063
76ribosome assembly (GO:0042255)3.09970704
77purine nucleoside triphosphate biosynthetic process (GO:0009145)3.08957343
78cellular component biogenesis (GO:0044085)3.08691520
79DNA replication-independent nucleosome organization (GO:0034724)3.04880702
80DNA replication-independent nucleosome assembly (GO:0006336)3.04880702
81establishment of integrated proviral latency (GO:0075713)3.03846709
82pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.99313123
83nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97886356
84* protein localization to organelle (GO:0033365)2.97145997
85ribonucleoside triphosphate biosynthetic process (GO:0009201)2.90925454
86pseudouridine synthesis (GO:0001522)2.89499204
87membrane disassembly (GO:0030397)2.88892478
88nuclear envelope disassembly (GO:0051081)2.88892478
89regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.88104698
90nuclear pore organization (GO:0006999)2.87632195
91proteasome assembly (GO:0043248)2.86844051
92DNA replication-dependent nucleosome assembly (GO:0006335)2.86742634
93DNA replication-dependent nucleosome organization (GO:0034723)2.86742634
94aerobic respiration (GO:0009060)2.85320469
95spliceosomal complex assembly (GO:0000245)2.83340142
96protein targeting to mitochondrion (GO:0006626)2.82659408
97transcription-coupled nucleotide-excision repair (GO:0006283)2.82435078
98* gene expression (GO:0010467)2.82371692
99metaphase plate congression (GO:0051310)2.80471412
100protein neddylation (GO:0045116)2.80371929
101deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.79822044
102nuclear pore complex assembly (GO:0051292)2.72311650
103* ribonucleoprotein complex assembly (GO:0022618)2.71591941
104establishment of protein localization to mitochondrion (GO:0072655)2.70369130
105negative regulation of RNA splicing (GO:0033119)2.69677241
106purine nucleoside monophosphate biosynthetic process (GO:0009127)2.69618350
107purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.69618350
108negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.68841935
109histone exchange (GO:0043486)2.67976011
110viral mRNA export from host cell nucleus (GO:0046784)2.67170260
111regulation of spindle organization (GO:0090224)2.66590521
112establishment of chromosome localization (GO:0051303)2.63373280
113hydrogen ion transmembrane transport (GO:1902600)2.62154867
114GTP biosynthetic process (GO:0006183)2.61042040
115telomere maintenance (GO:0000723)2.60805289
116* cellular component disassembly (GO:0022411)2.60668729
117anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.59881589
118regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.59617860
119telomere organization (GO:0032200)2.59377459
120RNA splicing, via transesterification reactions (GO:0000375)2.58876846
121histone mRNA metabolic process (GO:0008334)2.58592805
122protein localization to mitochondrion (GO:0070585)2.57278834
123UTP biosynthetic process (GO:0006228)2.57207259
124termination of RNA polymerase II transcription (GO:0006369)2.56887339
125mRNA splicing, via spliceosome (GO:0000398)2.56679228
126RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.56679228
127* ribonucleoprotein complex subunit organization (GO:0071826)2.56487992
128positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.56183089
129pyrimidine nucleotide catabolic process (GO:0006244)2.55128487
130termination of RNA polymerase III transcription (GO:0006386)2.54698673
131transcription elongation from RNA polymerase III promoter (GO:0006385)2.54698673
132cell cycle G1/S phase transition (GO:0044843)2.53964893
133G1/S transition of mitotic cell cycle (GO:0000082)2.53964893
134nucleoside triphosphate biosynthetic process (GO:0009142)2.53509660
135negative regulation of ligase activity (GO:0051352)2.53398773
136negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.53398773
137ncRNA processing (GO:0034470)2.53206860
138exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.51807435
139attachment of spindle microtubules to kinetochore (GO:0008608)2.51744789
140rRNA modification (GO:0000154)2.49975970
141DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.48268332
142ncRNA 3-end processing (GO:0043628)2.48241630
143regulation of nuclear cell cycle DNA replication (GO:0033262)2.47408570
144nucleobase-containing small molecule interconversion (GO:0015949)2.46643594
145mitotic sister chromatid segregation (GO:0000070)2.45516686
146intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.45353285
147tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.44897797
148RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.44897797

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.69031560
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.37595695
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72609917
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30375175
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.28532476
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.04988415
7* EST1_17652178_ChIP-ChIP_JURKAT_Human2.90624064
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90220535
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.88106160
10* GABP_17652178_ChIP-ChIP_JURKAT_Human2.78850246
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74799886
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73137922
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.64535113
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53588865
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.50101856
16XRN2_22483619_ChIP-Seq_HELA_Human2.42457365
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.33284978
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32431317
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.32154649
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29992351
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24824595
22VDR_23849224_ChIP-Seq_CD4+_Human2.24093696
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18551007
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08978403
25DCP1A_22483619_ChIP-Seq_HELA_Human1.97625153
26FOXP3_21729870_ChIP-Seq_TREG_Human1.96002378
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.93074043
28TTF2_22483619_ChIP-Seq_HELA_Human1.92300031
29* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89933641
30ELK1_19687146_ChIP-ChIP_HELA_Human1.89009420
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88872574
32* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81676647
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.78039443
34MYC_22102868_ChIP-Seq_BL_Human1.73300331
35AR_21909140_ChIP-Seq_LNCAP_Human1.72863090
36* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68773416
37* GABP_19822575_ChIP-Seq_HepG2_Human1.65810819
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64984434
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58529689
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57540860
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56613947
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55524862
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55211368
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54566050
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.54513950
46CIITA_25753668_ChIP-Seq_RAJI_Human1.51714843
47* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48667110
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47559575
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46936528
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46048445
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45270320
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43032863
53* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38429635
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38285565
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33961376
56KDM5A_27292631_Chip-Seq_BREAST_Human1.31963624
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.30855484
58VDR_21846776_ChIP-Seq_THP-1_Human1.29427276
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.29157068
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27319313
61* SPI1_23547873_ChIP-Seq_NB4_Human1.26348276
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25300172
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22751401
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.18816252
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18120977
66* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15880595
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11551235
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08858113
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08567987
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.08478404
71TFEB_21752829_ChIP-Seq_HELA_Human1.08218130
72* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07836319
73* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06229447
74TP63_17297297_ChIP-ChIP_HaCaT_Human1.05890879
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.05701667
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04617197
77MYC_18940864_ChIP-ChIP_HL60_Human1.02838808
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02453951
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01446918
80SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00895823
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00799958
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00354090
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00097193
84* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99392727
85IRF8_22096565_ChIP-ChIP_GC-B_Human0.98792893
86SOX2_16153702_ChIP-ChIP_HESCs_Human0.98761395
87MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98276948
88CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98171359
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97946721
90MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97433122
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97023646
92* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96475432
93MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96418215
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96361846
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94820405
96SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93933607
97ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93920461
98* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92762023
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91770483
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91090361
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90459074
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89727843
103* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88981756
104PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87251823
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86467247
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86228559
107ZNF263_19887448_ChIP-Seq_K562_Human0.85370416
108* FOXP1_21924763_ChIP-Seq_HESCs_Human0.84223758
109SOX2_18692474_ChIP-Seq_MEFs_Mouse0.84122704
110MAF_26560356_Chip-Seq_TH1_Human0.81995014
111NANOG_16153702_ChIP-ChIP_HESCs_Human0.81964273
112KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.81150956
113KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.81150956
114KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.81150956
115MYB_26560356_Chip-Seq_TH1_Human0.80865419
116* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75675255
117ELF5_23300383_ChIP-Seq_T47D_Human0.72044420
118PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.71364765

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.53427068
2MP0006292_abnormal_olfactory_placode4.15342671
3MP0004957_abnormal_blastocyst_morpholog3.60799777
4MP0010094_abnormal_chromosome_stability3.51286467
5MP0003111_abnormal_nucleus_morphology3.24926511
6MP0003077_abnormal_cell_cycle3.22369453
7MP0008995_early_reproductive_senescence2.94200933
8MP0008057_abnormal_DNA_replication2.69979000
9MP0002396_abnormal_hematopoietic_system2.61720802
10MP0008007_abnormal_cellular_replicative2.58767405
11MP0008058_abnormal_DNA_repair2.49684082
12MP0009379_abnormal_foot_pigmentation2.30729310
13MP0003136_yellow_coat_color2.27812890
14MP0002938_white_spotting2.19619843
15MP0008932_abnormal_embryonic_tissue1.99681851
16MP0000490_abnormal_crypts_of1.94568595
17MP0004808_abnormal_hematopoietic_stem1.92680593
18MP0010352_gastrointestinal_tract_polyps1.89176525
19MP0000372_irregular_coat_pigmentation1.81940226
20MP0000350_abnormal_cell_proliferation1.81489473
21MP0003786_premature_aging1.78647225
22MP0003123_paternal_imprinting1.74702661
23MP0001835_abnormal_antigen_presentation1.72771955
24MP0003763_abnormal_thymus_physiology1.71846980
25MP0008789_abnormal_olfactory_epithelium1.68141217
26MP0001730_embryonic_growth_arrest1.66118378
27MP0009333_abnormal_splenocyte_physiolog1.62060439
28MP0006054_spinal_hemorrhage1.61974868
29MP0000566_synostosis1.56649699
30MP0004147_increased_porphyrin_level1.54402678
31MP0006036_abnormal_mitochondrial_physio1.52403359
32MP0002163_abnormal_gland_morphology1.50571495
33MP0005397_hematopoietic_system_phenotyp1.49011709
34MP0001545_abnormal_hematopoietic_system1.49011709
35MP0003186_abnormal_redox_activity1.48401401
36MP0001529_abnormal_vocalization1.47824570
37MP0010307_abnormal_tumor_latency1.45618017
38MP0002166_altered_tumor_susceptibility1.44046956
39MP0002398_abnormal_bone_marrow1.42944407
40MP0002019_abnormal_tumor_incidence1.41511467
41MP0003567_abnormal_fetal_cardiomyocyte1.40260886
42MP0000858_altered_metastatic_potential1.37989383
43MP0000313_abnormal_cell_death1.36274307
44MP0006072_abnormal_retinal_apoptosis1.36110199
45MP0002722_abnormal_immune_system1.32238590
46MP0001286_abnormal_eye_development1.31741185
47MP0006035_abnormal_mitochondrial_morpho1.30964731
48MP0002006_tumorigenesis1.29839398
49MP0000689_abnormal_spleen_morphology1.27558571
50MP0001697_abnormal_embryo_size1.27288737
51MP0005380_embryogenesis_phenotype1.26001590
52MP0001672_abnormal_embryogenesis/_devel1.26001590
53MP0000703_abnormal_thymus_morphology1.25493534
54MP0003436_decreased_susceptibility_to1.24479764
55MP0005499_abnormal_olfactory_system1.23565432
56MP0005394_taste/olfaction_phenotype1.23565432
57MP0003938_abnormal_ear_development1.23037320
58MP0001800_abnormal_humoral_immune1.22423535
59MP0002080_prenatal_lethality1.18942850
60MP0003011_delayed_dark_adaptation1.17259191
61MP0003984_embryonic_growth_retardation1.16449143
62MP0002277_abnormal_respiratory_mucosa1.16230790
63MP0009785_altered_susceptibility_to1.16035661
64MP0001853_heart_inflammation1.15642489
65MP0002452_abnormal_antigen_presenting1.15380135
66MP0002429_abnormal_blood_cell1.15374128
67MP0002088_abnormal_embryonic_growth/wei1.14518159
68MP0000685_abnormal_immune_system1.13677061
69MP0005671_abnormal_response_to1.13566518
70MP0002420_abnormal_adaptive_immunity1.12200239
71MP0000716_abnormal_immune_system1.11471801
72MP0002148_abnormal_hypersensitivity_rea1.10749108
73MP0001819_abnormal_immune_cell1.10477795
74MP0000631_abnormal_neuroendocrine_gland1.09027126
75MP0002653_abnormal_ependyma_morphology1.08425788
76MP0002086_abnormal_extraembryonic_tissu1.06373193
77MP0004197_abnormal_fetal_growth/weight/1.05261795
78MP0002132_abnormal_respiratory_system1.04081557
79MP0003315_abnormal_perineum_morphology1.03633530
80MP0002405_respiratory_system_inflammati1.02817379
81MP0010155_abnormal_intestine_physiology1.02702208
82MP0005174_abnormal_tail_pigmentation1.02448109
83MP0005025_abnormal_response_to1.01242645
84MP0004142_abnormal_muscle_tone1.00648283
85MP0003718_maternal_effect0.99973763
86MP0005000_abnormal_immune_tolerance0.99713851
87MP0009697_abnormal_copulation0.99571444
88MP0002723_abnormal_immune_serum0.98754625
89MP0000049_abnormal_middle_ear0.98459173
90MP0005076_abnormal_cell_differentiation0.98380696
91MP0002085_abnormal_embryonic_tissue0.97557183
92MP0009053_abnormal_anal_canal0.95790538
93MP0005023_abnormal_wound_healing0.95363483
94MP0002095_abnormal_skin_pigmentation0.95258099
95MP0003941_abnormal_skin_development0.94013656
96MP0002697_abnormal_eye_size0.93952340
97MP0001346_abnormal_lacrimal_gland0.92448332
98MP0010030_abnormal_orbit_morphology0.90079424
99MP0002160_abnormal_reproductive_system0.89623093
100MP0005075_abnormal_melanosome_morpholog0.88750985
101MP0002638_abnormal_pupillary_reflex0.88191302
102MP0003806_abnormal_nucleotide_metabolis0.88088528
103MP0001929_abnormal_gametogenesis0.87450544
104MP0001873_stomach_inflammation0.86571060
105MP0002084_abnormal_developmental_patter0.86563045
106MP0000465_gastrointestinal_hemorrhage0.84884695
107MP0008877_abnormal_DNA_methylation0.84868949
108MP0002009_preneoplasia0.84701303
109MP0003121_genomic_imprinting0.84383327
110MP0005377_hearing/vestibular/ear_phenot0.84205325
111MP0003878_abnormal_ear_physiology0.84205325
112MP0000653_abnormal_sex_gland0.83978647
113MP0003566_abnormal_cell_adhesion0.83020095
114MP0005389_reproductive_system_phenotype0.81912153
115MP0003448_altered_tumor_morphology0.81838695
116MP0003122_maternal_imprinting0.80841126
117MP0002877_abnormal_melanocyte_morpholog0.80776269
118MP0001293_anophthalmia0.79419647
119MP0001881_abnormal_mammary_gland0.77611446
120MP0002419_abnormal_innate_immunity0.76642909
121MP0009278_abnormal_bone_marrow0.75104135
122MP0005084_abnormal_gallbladder_morpholo0.71883688
123MP0001119_abnormal_female_reproductive0.71595667
124MP0001915_intracranial_hemorrhage0.71466836
125MP0005408_hypopigmentation0.71065858
126MP0002234_abnormal_pharynx_morphology0.70611863
127MP0002210_abnormal_sex_determination0.70511824
128MP0003937_abnormal_limbs/digits/tail_de0.69951982
129MP0005387_immune_system_phenotype0.69227717
130MP0001790_abnormal_immune_system0.69227717
131MP0001845_abnormal_inflammatory_respons0.68641702
132MP0000477_abnormal_intestine_morphology0.68420121
133MP0001764_abnormal_homeostasis0.67725070
134MP0002233_abnormal_nose_morphology0.67390255
135MP0005464_abnormal_platelet_physiology0.67232049
136MP0002092_abnormal_eye_morphology0.67171187
137MP0005379_endocrine/exocrine_gland_phen0.66146728
138MP0004145_abnormal_muscle_electrophysio0.65144869
139MP0000358_abnormal_cell_content/0.65130513
140MP0000343_altered_response_to0.65103002
141MP0001919_abnormal_reproductive_system0.63905202
142MP0002111_abnormal_tail_morphology0.63574365
143MP0005501_abnormal_skin_physiology0.62295214
144MP0005391_vision/eye_phenotype0.61838999
145MP0001145_abnormal_male_reproductive0.61290027
146MP0003890_abnormal_embryonic-extraembry0.61087344

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.20879561
2Abnormality of cells of the erythroid lineage (HP:0012130)6.06321701
3Abnormal number of erythroid precursors (HP:0012131)5.73734194
4Acute necrotizing encephalopathy (HP:0006965)5.04518453
5Abnormal mitochondria in muscle tissue (HP:0008316)4.66693044
6Increased hepatocellular lipid droplets (HP:0006565)4.61880810
7Acute encephalopathy (HP:0006846)4.40164270
8Mitochondrial inheritance (HP:0001427)4.39359950
9Macrocytic anemia (HP:0001972)4.12630514
10Lipid accumulation in hepatocytes (HP:0006561)4.07584872
11Progressive macrocephaly (HP:0004481)4.05216303
12Pallor (HP:0000980)3.98413838
13Increased CSF lactate (HP:0002490)3.83979370
14Thrombocytosis (HP:0001894)3.82274474
15Hepatocellular necrosis (HP:0001404)3.70019520
16Degeneration of anterior horn cells (HP:0002398)3.66248309
17Abnormality of the anterior horn cell (HP:0006802)3.66248309
18Aplastic anemia (HP:0001915)3.60117838
19Increased intramyocellular lipid droplets (HP:0012240)3.45959592
20Birth length less than 3rd percentile (HP:0003561)3.43463537
21Colon cancer (HP:0003003)3.33546632
22Hepatic necrosis (HP:0002605)3.33522106
23Oral leukoplakia (HP:0002745)3.30333993
24Cerebral edema (HP:0002181)3.28650776
2511 pairs of ribs (HP:0000878)3.21281898
26Renal Fanconi syndrome (HP:0001994)3.16331629
27Aplasia/Hypoplasia of the sacrum (HP:0008517)3.10201941
28Respiratory difficulties (HP:0002880)2.95820638
293-Methylglutaconic aciduria (HP:0003535)2.90072396
30Breast hypoplasia (HP:0003187)2.86087173
31Increased muscle lipid content (HP:0009058)2.86040513
32Carpal bone hypoplasia (HP:0001498)2.78519144
33Absent thumb (HP:0009777)2.67587125
34Exercise intolerance (HP:0003546)2.61676319
35Selective tooth agenesis (HP:0001592)2.60905842
36Stenosis of the external auditory canal (HP:0000402)2.60080403
37Lactic acidosis (HP:0003128)2.57382420
38Increased serum lactate (HP:0002151)2.55543926
39Multiple enchondromatosis (HP:0005701)2.54499781
40Chromsome breakage (HP:0040012)2.49038578
41Rough bone trabeculation (HP:0100670)2.48759425
42Microvesicular hepatic steatosis (HP:0001414)2.47897839
43IgM deficiency (HP:0002850)2.45415894
44Trismus (HP:0000211)2.44388811
45Myelodysplasia (HP:0002863)2.41702543
46Leukodystrophy (HP:0002415)2.40252299
47Septo-optic dysplasia (HP:0100842)2.38991716
48Respiratory failure (HP:0002878)2.33740394
49Patellar aplasia (HP:0006443)2.31448343
50Abnormal hemoglobin (HP:0011902)2.28423538
51Aplasia/Hypoplasia of the patella (HP:0006498)2.28280199
52Optic disc pallor (HP:0000543)2.26782121
53Meckel diverticulum (HP:0002245)2.24250499
54Microretrognathia (HP:0000308)2.23490088
55Premature graying of hair (HP:0002216)2.20523463
56Agnosia (HP:0010524)2.18685403
57Abnormality of chromosome stability (HP:0003220)2.18439367
58Abnormality of reticulocytes (HP:0004312)2.13700366
59Abnormality of the preputium (HP:0100587)2.13312857
60Lymphoma (HP:0002665)2.11354163
61Abnormality of the ileum (HP:0001549)2.09435318
62Neoplasm of the pancreas (HP:0002894)2.08702062
63Type I transferrin isoform profile (HP:0003642)2.07792151
64Missing ribs (HP:0000921)2.05561606
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.05554751
66Chromosomal breakage induced by crosslinking agents (HP:0003221)2.03389321
67Abnormality of the parietal bone (HP:0002696)2.03308364
68Partial duplication of thumb phalanx (HP:0009944)1.98168362
69Amaurosis fugax (HP:0100576)1.95589122
70Cleft eyelid (HP:0000625)1.94934268
71Maternal diabetes (HP:0009800)1.94470800
72Basal cell carcinoma (HP:0002671)1.94433470
73Bone marrow hypocellularity (HP:0005528)1.92572738
74Petechiae (HP:0000967)1.92370524
75Hyperglycinemia (HP:0002154)1.91947416
76Abnormality of renal resorption (HP:0011038)1.90245014
77Medulloblastoma (HP:0002885)1.90213744
78Depressed nasal ridge (HP:0000457)1.90054378
79Poor head control (HP:0002421)1.88788863
80Partial duplication of the phalanx of hand (HP:0009999)1.87843895
81Abnormality of T cell physiology (HP:0011840)1.87758334
82Triphalangeal thumb (HP:0001199)1.87456241
83Pancytopenia (HP:0001876)1.86938100
84Lethargy (HP:0001254)1.86878006
85Cellular immunodeficiency (HP:0005374)1.86869062
86Absent septum pellucidum (HP:0001331)1.86464767
87Increased serum pyruvate (HP:0003542)1.84968317
88Migraine (HP:0002076)1.84411513
89Congenital, generalized hypertrichosis (HP:0004540)1.82102144
90Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81037601
91Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81037601
92Granulocytopenia (HP:0001913)1.80938976
93Tracheoesophageal fistula (HP:0002575)1.79778632
94Abnormal trabecular bone morphology (HP:0100671)1.78953346
95Glossoptosis (HP:0000162)1.77567293
96Atresia of the external auditory canal (HP:0000413)1.76125305
97Sparse eyelashes (HP:0000653)1.74721929
98Abnormality of T cells (HP:0002843)1.74258031
99Elevated erythrocyte sedimentation rate (HP:0003565)1.73985451
100Hyperphosphaturia (HP:0003109)1.73710372
101Hypoplasia of the radius (HP:0002984)1.73598440
102Squamous cell carcinoma (HP:0002860)1.73550210
103Abnormal lung lobation (HP:0002101)1.73547550
104Bilateral microphthalmos (HP:0007633)1.72530680
105Rib fusion (HP:0000902)1.71429728
106Neoplasm of the colon (HP:0100273)1.71268584
107Aplasia/Hypoplasia of the uvula (HP:0010293)1.70715004
108Asplenia (HP:0001746)1.70620202
109Pulmonary fibrosis (HP:0002206)1.69737269
110Abnormality of the septum pellucidum (HP:0007375)1.69613453
111Duplication of thumb phalanx (HP:0009942)1.69585758
112Duodenal stenosis (HP:0100867)1.69486501
113Small intestinal stenosis (HP:0012848)1.69486501
114Woolly hair (HP:0002224)1.68775574
115Horseshoe kidney (HP:0000085)1.67320326
116Optic nerve coloboma (HP:0000588)1.67017258
117Thick lower lip vermilion (HP:0000179)1.66487440
118Panhypogammaglobulinemia (HP:0003139)1.65927723
119Rhabdomyosarcoma (HP:0002859)1.65875611
120Irregular epiphyses (HP:0010582)1.65340379
121Neutropenia (HP:0001875)1.65034300
122Abnormal number of incisors (HP:0011064)1.64979198
123Abnormality of DNA repair (HP:0003254)1.63235000
124Exertional dyspnea (HP:0002875)1.63124238
125Poikiloderma (HP:0001029)1.62095611
126Abnormality of glycolysis (HP:0004366)1.61908557
127Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.61793209
128Secondary amenorrhea (HP:0000869)1.60239267
129Recurrent abscess formation (HP:0002722)1.60114404
130Impulsivity (HP:0100710)1.59035227
131Recurrent viral infections (HP:0004429)1.57975140
132Acute myeloid leukemia (HP:0004808)1.56457437
133Premature ovarian failure (HP:0008209)1.56425433
134Cellulitis (HP:0100658)1.56148023
135Aplasia/Hypoplasia of the spleen (HP:0010451)1.55625148
136IgG deficiency (HP:0004315)1.55420456
137Cutaneous melanoma (HP:0012056)1.55343201
138Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.54444614
139Aplasia/Hypoplasia of the thymus (HP:0010515)1.54327582
140Abnormality of urine glucose concentration (HP:0011016)1.53943153
141Glycosuria (HP:0003076)1.53943153
142Muscle fiber atrophy (HP:0100295)1.52564460
143Atrophy/Degeneration involving motor neurons (HP:0007373)1.52229584
144Syringomyelia (HP:0003396)1.52150822
145Spinal cord lesions (HP:0100561)1.52150822
146Reduced antithrombin III activity (HP:0001976)1.52041625
147Concave nail (HP:0001598)1.51578759
148Ependymoma (HP:0002888)1.51497821
149Clubbing of toes (HP:0100760)1.50881840
150Seborrheic dermatitis (HP:0001051)1.50208894
151Emotional lability (HP:0000712)1.48172301
152Pancreatic cysts (HP:0001737)1.43119393
153Anophthalmia (HP:0000528)1.41355973
154Short middle phalanx of the 5th finger (HP:0004220)1.39239619

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.44137587
2NME23.66794450
3EIF2AK13.36300567
4WEE13.29447302
5BUB13.19064205
6CDC72.87491238
7SRPK12.63913964
8TLK12.60162455
9CDK192.37767746
10EIF2AK32.19399384
11MKNK12.19348402
12NEK22.00828195
13PIM21.93385576
14RPS6KB21.93091244
15RPS6KA41.77498029
16VRK11.76052297
17PASK1.72330456
18STK161.69171180
19PLK41.68267135
20BRSK21.67659012
21TGFBR11.63436336
22MAP4K11.63358820
23TESK21.60338870
24ACVR1B1.58908405
25MKNK21.57130437
26LRRK21.54125326
27NEK11.51846717
28TSSK61.50401231
29CDK71.49923838
30AURKB1.46668986
31EEF2K1.43766241
32ZAK1.43272495
33PIM11.42904510
34PLK11.41950383
35TAF11.34086297
36FLT31.30705795
37ATR1.28968950
38STK101.28715608
39TTK1.28200956
40NUAK11.26305919
41SCYL21.21906409
42STK41.19622031
43PAK41.18202359
44DYRK31.17730773
45MST41.16217911
46EIF2AK21.11432073
47TEC1.10594306
48PKN21.09309624
49CDK41.08572137
50MAP3K81.07737978
51TESK11.07411324
52NEK91.06411794
53DYRK21.05817093
54IRAK41.05662695
55PLK31.04801566
56BTK1.00238631
57IRAK30.99292625
58MAP2K30.95626250
59KDR0.88600988
60AURKA0.87689598
61EPHA20.86923263
62JAK30.85786189
63MAP3K110.82149924
64ZAP700.82121584
65ITK0.82069845
66CHEK20.80537558
67IKBKB0.78935227
68BLK0.77368518
69CDK60.77025925
70PBK0.75252371
71WNK40.74891970
72CHEK10.73766543
73SMG10.71471414
74DAPK30.69590167
75CCNB10.69027306
76BRSK10.68893225
77TXK0.68141334
78TAOK30.67934168
79MAPKAPK30.67269815
80ILK0.67144304
81CDK80.66000321
82CSNK2A10.65831931
83CSNK2A20.64557651
84TYK20.62886852
85MAP3K100.61713226
86MAP3K30.61191723
87MUSK0.59856502
88KIT0.59734847
89MAPK150.58868462
90NME10.58393111
91ATM0.57841898
92BRAF0.56822869
93RPS6KA50.56641942
94CLK10.56188675
95BMPR20.55039042
96CDK20.54186800
97MAP2K20.53919421
98MAPKAPK50.53483122
99CDK120.53403550
100MAP3K140.50847114
101STK240.50786301
102BCKDK0.47770738
103NLK0.47592896
104ALK0.46403009
105CSNK1E0.45205508
106PAK10.45134000
107DYRK1B0.44785783
108CHUK0.44568104
109RPS6KL10.44416309
110RPS6KC10.44416309
111RPS6KA60.42479670
112PRKCI0.42327182
113GRK60.41827907
114CDK10.41199655
115LYN0.40970642
116CDK30.40602262
117PDK20.40082653
118MAP4K20.39901109
119IKBKE0.39525021
120SYK0.37800946
121TBK10.36371148
122STK30.35948325
123CSF1R0.35760449
124FGFR20.35715227
125TYRO30.32044235
126INSRR0.30819352
127MAP3K120.30422616
128ARAF0.28740994
129FGFR10.28601117
130PIK3CA0.27728381
131MARK30.26780910

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030105.40227024
2DNA replication_Homo sapiens_hsa030304.42600036
3Mismatch repair_Homo sapiens_hsa034303.65351849
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.09762986
5Proteasome_Homo sapiens_hsa030503.08060688
6Spliceosome_Homo sapiens_hsa030403.03002556
7RNA polymerase_Homo sapiens_hsa030202.93326195
8Homologous recombination_Homo sapiens_hsa034402.77873290
9Base excision repair_Homo sapiens_hsa034102.69190480
10RNA transport_Homo sapiens_hsa030132.55951109
11Nucleotide excision repair_Homo sapiens_hsa034202.51979036
12One carbon pool by folate_Homo sapiens_hsa006702.50334129
13Alzheimers disease_Homo sapiens_hsa050102.31148153
14Pyrimidine metabolism_Homo sapiens_hsa002402.27815520
15Cell cycle_Homo sapiens_hsa041102.12251030
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94937390
17Fanconi anemia pathway_Homo sapiens_hsa034601.87381439
18Non-homologous end-joining_Homo sapiens_hsa034501.77150100
19Cardiac muscle contraction_Homo sapiens_hsa042601.73914901
20RNA degradation_Homo sapiens_hsa030181.70554203
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59364717
22p53 signaling pathway_Homo sapiens_hsa041151.57575611
23Basal transcription factors_Homo sapiens_hsa030221.53670885
24Protein export_Homo sapiens_hsa030601.33329841
25mRNA surveillance pathway_Homo sapiens_hsa030151.32992552
26Antigen processing and presentation_Homo sapiens_hsa046121.25599325
27Herpes simplex infection_Homo sapiens_hsa051681.22345717
28Systemic lupus erythematosus_Homo sapiens_hsa053221.18156032
29Epstein-Barr virus infection_Homo sapiens_hsa051691.17305074
30Purine metabolism_Homo sapiens_hsa002301.10315988
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08056101
32Primary immunodeficiency_Homo sapiens_hsa053401.04929528
33Legionellosis_Homo sapiens_hsa051340.93682335
34Viral carcinogenesis_Homo sapiens_hsa052030.89069123
35Pyruvate metabolism_Homo sapiens_hsa006200.84664307
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82375817
37Measles_Homo sapiens_hsa051620.81728861
38Sulfur relay system_Homo sapiens_hsa041220.79965190
39Pentose phosphate pathway_Homo sapiens_hsa000300.79156852
40NF-kappa B signaling pathway_Homo sapiens_hsa040640.78112512
41Folate biosynthesis_Homo sapiens_hsa007900.77760547
42Propanoate metabolism_Homo sapiens_hsa006400.76757209
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75837101
44Thyroid cancer_Homo sapiens_hsa052160.75317978
45HTLV-I infection_Homo sapiens_hsa051660.75138464
46Huntingtons disease_Homo sapiens_hsa050160.74059800
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71876550
48Parkinsons disease_Homo sapiens_hsa050120.70913047
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.69606342
50Selenocompound metabolism_Homo sapiens_hsa004500.67778631
51Apoptosis_Homo sapiens_hsa042100.66983173
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66596248
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66054063
54Small cell lung cancer_Homo sapiens_hsa052220.63567327
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63494550
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63428738
57Leishmaniasis_Homo sapiens_hsa051400.62115631
58Hematopoietic cell lineage_Homo sapiens_hsa046400.61843863
59Metabolic pathways_Homo sapiens_hsa011000.60072601
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59088782
61N-Glycan biosynthesis_Homo sapiens_hsa005100.57168357
62Glutathione metabolism_Homo sapiens_hsa004800.56016681
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.55371848
64Basal cell carcinoma_Homo sapiens_hsa052170.54566557
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53879478
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53593332
67Fatty acid elongation_Homo sapiens_hsa000620.53344478
68Influenza A_Homo sapiens_hsa051640.53122482
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52083531
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.51793459
71Hepatitis B_Homo sapiens_hsa051610.51295462
72MicroRNAs in cancer_Homo sapiens_hsa052060.51233333
73Shigellosis_Homo sapiens_hsa051310.48165129
74Allograft rejection_Homo sapiens_hsa053300.47719272
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47281224
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47095396
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.45571750
78Oxidative phosphorylation_Homo sapiens_hsa001900.45353717
79Acute myeloid leukemia_Homo sapiens_hsa052210.45034746
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45005706
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41369850
82Asthma_Homo sapiens_hsa053100.41057242
83Biosynthesis of amino acids_Homo sapiens_hsa012300.40727821
84Viral myocarditis_Homo sapiens_hsa054160.40467902
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40308806
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.39257894
87Autoimmune thyroid disease_Homo sapiens_hsa053200.39213062
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38616193
89Chronic myeloid leukemia_Homo sapiens_hsa052200.38595874
90Graft-versus-host disease_Homo sapiens_hsa053320.38350412
91Vitamin digestion and absorption_Homo sapiens_hsa049770.37644293
92Galactose metabolism_Homo sapiens_hsa000520.37355170
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36773147
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36706686
95Peroxisome_Homo sapiens_hsa041460.36202076
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36129073
97Oocyte meiosis_Homo sapiens_hsa041140.36051970
98Steroid biosynthesis_Homo sapiens_hsa001000.35228625
99HIF-1 signaling pathway_Homo sapiens_hsa040660.35012634
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.32675187
101B cell receptor signaling pathway_Homo sapiens_hsa046620.32584411
102Other glycan degradation_Homo sapiens_hsa005110.31939328
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31933302
104TGF-beta signaling pathway_Homo sapiens_hsa043500.31380836
105Bladder cancer_Homo sapiens_hsa052190.31307028
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31222375
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30330073
108Notch signaling pathway_Homo sapiens_hsa043300.29682790
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.27820917
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27368719
111Linoleic acid metabolism_Homo sapiens_hsa005910.27268572
112Toxoplasmosis_Homo sapiens_hsa051450.26913134
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26875606
114Arachidonic acid metabolism_Homo sapiens_hsa005900.26827950
115Fat digestion and absorption_Homo sapiens_hsa049750.26752071
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24719550
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23032261
118Carbon metabolism_Homo sapiens_hsa012000.22669723
119Pertussis_Homo sapiens_hsa051330.22322838
120Pathways in cancer_Homo sapiens_hsa052000.21716625
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.20994949
122Butanoate metabolism_Homo sapiens_hsa006500.20552367
123Malaria_Homo sapiens_hsa051440.20330525
124Renin-angiotensin system_Homo sapiens_hsa046140.20168549
125Nitrogen metabolism_Homo sapiens_hsa009100.19774148
126Colorectal cancer_Homo sapiens_hsa052100.19527048
127Tyrosine metabolism_Homo sapiens_hsa003500.18308536
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17510018
129Alcoholism_Homo sapiens_hsa050340.16744250
130Hedgehog signaling pathway_Homo sapiens_hsa043400.16616787
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11560420
132Type I diabetes mellitus_Homo sapiens_hsa049400.11091926
133Wnt signaling pathway_Homo sapiens_hsa043100.10590343
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.09233120
135Fructose and mannose metabolism_Homo sapiens_hsa000510.08960394
136Arginine and proline metabolism_Homo sapiens_hsa003300.06059229
137Chemical carcinogenesis_Homo sapiens_hsa052040.05105396
138SNARE interactions in vesicular transport_Homo sapiens_hsa041300.04787251
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.04108045
140Fatty acid metabolism_Homo sapiens_hsa012120.00435857

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