RPS26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.56302043
2ribosomal small subunit assembly (GO:0000028)8.02743441
3* viral transcription (GO:0019083)7.88946180
4* translational termination (GO:0006415)7.60102885
5energy coupled proton transport, down electrochemical gradient (GO:0015985)7.54423856
6ATP synthesis coupled proton transport (GO:0015986)7.54423856
7ribosomal small subunit biogenesis (GO:0042274)7.03764947
8* translational elongation (GO:0006414)6.61318619
9* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.40608352
10maturation of SSU-rRNA (GO:0030490)6.27336873
11* protein targeting to ER (GO:0045047)6.25642607
12* cotranslational protein targeting to membrane (GO:0006613)6.25067522
13* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.08388627
14* establishment of protein localization to endoplasmic reticulum (GO:0072599)5.95890778
15* translational initiation (GO:0006413)5.90809554
16* viral life cycle (GO:0019058)5.90774768
17* cellular protein complex disassembly (GO:0043624)5.89965545
18* protein localization to endoplasmic reticulum (GO:0070972)5.84511100
19chaperone-mediated protein transport (GO:0072321)5.76846444
20respiratory electron transport chain (GO:0022904)5.76834623
21electron transport chain (GO:0022900)5.63220968
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.58331883
23establishment of protein localization to mitochondrial membrane (GO:0090151)5.58056283
24* protein complex disassembly (GO:0043241)5.28225680
25ribosomal large subunit biogenesis (GO:0042273)5.25720551
26* macromolecular complex disassembly (GO:0032984)4.92906849
27protein complex biogenesis (GO:0070271)4.64134899
28formation of translation preinitiation complex (GO:0001731)4.53222663
29* nuclear-transcribed mRNA catabolic process (GO:0000956)4.47154140
30mitochondrial respiratory chain complex assembly (GO:0033108)4.44295070
31ribonucleoprotein complex biogenesis (GO:0022613)4.43300574
32mitochondrial respiratory chain complex I assembly (GO:0032981)4.33013271
33NADH dehydrogenase complex assembly (GO:0010257)4.33013271
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.33013271
35* translation (GO:0006412)4.27199546
36regulation of mitochondrial translation (GO:0070129)4.26903245
37* mRNA catabolic process (GO:0006402)4.24038969
38DNA deamination (GO:0045006)4.23998342
39DNA strand elongation involved in DNA replication (GO:0006271)4.19083089
40ATP biosynthetic process (GO:0006754)4.12985388
41* protein targeting to membrane (GO:0006612)4.11567640
42* RNA catabolic process (GO:0006401)4.04028426
43telomere maintenance via semi-conservative replication (GO:0032201)4.02546966
44DNA strand elongation (GO:0022616)3.97900624
45oxidative phosphorylation (GO:0006119)3.91911446
46DNA unwinding involved in DNA replication (GO:0006268)3.88040539
47purine nucleoside triphosphate biosynthetic process (GO:0009145)3.85012113
48purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.84997334
49protein targeting to mitochondrion (GO:0006626)3.72792692
50rRNA processing (GO:0006364)3.63156715
51DNA replication initiation (GO:0006270)3.62658802
52hydrogen ion transmembrane transport (GO:1902600)3.60922339
53establishment of protein localization to mitochondrion (GO:0072655)3.56998625
54pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.54887104
55rRNA metabolic process (GO:0016072)3.50177843
56telomere maintenance via recombination (GO:0000722)3.49696271
57ribonucleoside triphosphate biosynthetic process (GO:0009201)3.48906139
58protein neddylation (GO:0045116)3.47120242
59inner mitochondrial membrane organization (GO:0007007)3.40006129
60protein localization to mitochondrion (GO:0070585)3.39505801
61cytochrome complex assembly (GO:0017004)3.38372448
62mitotic recombination (GO:0006312)3.37869280
63protein localization to kinetochore (GO:0034501)3.34871237
64cellular component biogenesis (GO:0044085)3.23898006
65mitochondrial transport (GO:0006839)3.22117534
66folic acid-containing compound biosynthetic process (GO:0009396)3.21758432
67telomere maintenance via telomere lengthening (GO:0010833)3.20952278
68ribosome biogenesis (GO:0042254)3.18934447
69respiratory chain complex IV assembly (GO:0008535)3.16269032
70DNA replication checkpoint (GO:0000076)3.16224580
71spliceosomal snRNP assembly (GO:0000387)3.15882601
72nucleobase biosynthetic process (GO:0046112)3.15560097
73rRNA methylation (GO:0031167)3.11186566
74* protein localization to membrane (GO:0072657)3.07394019
75nucleotide-excision repair, DNA gap filling (GO:0006297)3.07009158
76purine nucleoside monophosphate biosynthetic process (GO:0009127)3.06400470
77purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.06400470
78proton transport (GO:0015992)3.05600121
79nucleoside triphosphate biosynthetic process (GO:0009142)3.04639406
80ribosome assembly (GO:0042255)3.03885196
81establishment of integrated proviral latency (GO:0075713)3.02575467
82aerobic respiration (GO:0009060)3.00948307
83mitotic nuclear envelope disassembly (GO:0007077)3.00900446
84spliceosomal complex assembly (GO:0000245)2.99624011
85hydrogen transport (GO:0006818)2.98334417
86IMP biosynthetic process (GO:0006188)2.98049784
87chromatin remodeling at centromere (GO:0031055)2.97489598
88GTP biosynthetic process (GO:0006183)2.96368498
89sequestering of actin monomers (GO:0042989)2.94329345
90protein localization to chromosome, centromeric region (GO:0071459)2.93006204
91pseudouridine synthesis (GO:0001522)2.93005636
92CENP-A containing nucleosome assembly (GO:0034080)2.92882907
93pyrimidine nucleotide catabolic process (GO:0006244)2.91784999
94mitotic metaphase plate congression (GO:0007080)2.89701153
957-methylguanosine mRNA capping (GO:0006370)2.88965131
96ncRNA 3-end processing (GO:0043628)2.87557945
97intracellular protein transmembrane import (GO:0044743)2.86381905
98DNA replication-dependent nucleosome assembly (GO:0006335)2.83496603
99DNA replication-dependent nucleosome organization (GO:0034723)2.83496603
100protein-cofactor linkage (GO:0018065)2.82183789
101signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.81844238
102signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.81844238
103signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.81844238
1047-methylguanosine RNA capping (GO:0009452)2.81715769
105purine nucleobase biosynthetic process (GO:0009113)2.81371451
106regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.81011737
107deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.80662289
108DNA replication-independent nucleosome assembly (GO:0006336)2.78671875
109DNA replication-independent nucleosome organization (GO:0034724)2.78671875
110kinetochore organization (GO:0051383)2.77773721
111transcription-coupled nucleotide-excision repair (GO:0006283)2.77216892
112negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.76960388
113* establishment of protein localization to membrane (GO:0090150)2.75902728
114RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.73945958
115mRNA splicing, via spliceosome (GO:0000398)2.73945958
116RNA splicing, via transesterification reactions (GO:0000375)2.73630255
117membrane disassembly (GO:0030397)2.72948349
118nuclear envelope disassembly (GO:0051081)2.72948349
119negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.70904146
120* negative regulation of RNA splicing (GO:0033119)2.70319632
121proteasome assembly (GO:0043248)2.69435550
122regulation of protein heterodimerization activity (GO:0043497)2.69327905
123termination of RNA polymerase II transcription (GO:0006369)2.67460088
124* establishment of protein localization to organelle (GO:0072594)2.64095839
125IMP metabolic process (GO:0046040)2.62610147
126kinetochore assembly (GO:0051382)2.61604098
127termination of RNA polymerase III transcription (GO:0006386)2.59401167
128transcription elongation from RNA polymerase III promoter (GO:0006385)2.59401167
129anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.58696682
130exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.57674556
131ncRNA processing (GO:0034470)2.56135083
132regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.55143037
133* protein targeting (GO:0006605)2.55088825
134* gene expression (GO:0010467)2.54783093
135metaphase plate congression (GO:0051310)2.54389815
136positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.52935760
137ribonucleoprotein complex assembly (GO:0022618)2.52596259
138negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.52225128
139negative regulation of ligase activity (GO:0051352)2.52225128
140rRNA modification (GO:0000154)2.47901064
141heterochromatin organization (GO:0070828)2.44985356
142DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.44218048
143T cell apoptotic process (GO:0070231)2.42954589
144nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.42755954
145DNA-templated transcription, termination (GO:0006353)2.42716514
146ncRNA metabolic process (GO:0034660)2.41662532
147DNA duplex unwinding (GO:0032508)2.41583630

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.91647123
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.43328979
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.03833898
4* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.23062339
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.22225166
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.99516131
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.83384806
8* EST1_17652178_ChIP-ChIP_JURKAT_Human2.81258150
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80410291
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74088074
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.70714711
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70459447
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.68464521
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61924394
15* XRN2_22483619_ChIP-Seq_HELA_Human2.55383072
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53142874
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46297919
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44778911
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36866795
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13869301
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.13426144
22* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12274024
23* VDR_23849224_ChIP-Seq_CD4+_Human2.09242521
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08319187
25MYC_22102868_ChIP-Seq_BL_Human2.08282618
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02996996
27* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.95759218
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93137933
29* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93021188
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92295860
31TTF2_22483619_ChIP-Seq_HELA_Human1.91917258
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.88710150
33* DCP1A_22483619_ChIP-Seq_HELA_Human1.86531212
34* FOXP3_21729870_ChIP-Seq_TREG_Human1.84483799
35* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74453141
36GABP_19822575_ChIP-Seq_HepG2_Human1.68265403
37VDR_21846776_ChIP-Seq_THP-1_Human1.63729296
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.60724064
39* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60663903
40CIITA_25753668_ChIP-Seq_RAJI_Human1.60467655
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59066279
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57553617
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56144991
44ELK1_19687146_ChIP-ChIP_HELA_Human1.56108485
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.54773192
46* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52186046
47AR_21909140_ChIP-Seq_LNCAP_Human1.52154968
48* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50008390
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48544404
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47531866
51* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41488322
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.40257133
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38946503
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38073983
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38044723
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38028840
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36445740
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35962918
59* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35555555
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35495295
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31150731
62KDM5A_27292631_Chip-Seq_BREAST_Human1.31004641
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30635866
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28315249
65* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.27446709
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25302565
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24028063
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22724752
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22448579
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18839413
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18474343
72* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17691677
73* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17446626
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16687515
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16165586
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16165030
77* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15037722
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.14607334
79SPI1_23547873_ChIP-Seq_NB4_Human1.11653633
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11315001
81* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10036825
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09764601
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.06636791
84ELK1_22589737_ChIP-Seq_MCF10A_Human1.06202784
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05921127
86TFEB_21752829_ChIP-Seq_HELA_Human1.04821162
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02996441
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02758215
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00372815
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97388622
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96826445
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96802502
93NOTCH1_21737748_ChIP-Seq_TLL_Human0.96353475
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95667232
95* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94775326
96MYC_18940864_ChIP-ChIP_HL60_Human0.93424210
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93357988
98* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92688423
99* UTX_26944678_Chip-Seq_JUKART_Human0.91610138
100* TET1_21451524_ChIP-Seq_MESCs_Mouse0.90616496
101CTCF_26484167_Chip-Seq_Bcells_Mouse0.90169613
102* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90057714
103MAF_26560356_Chip-Seq_TH1_Human0.89651890
104* FOXP1_21924763_ChIP-Seq_HESCs_Human0.89114870
105KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.87987978
106* MAF_26560356_Chip-Seq_TH2_Human0.87276029
107* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.87088250
108* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85403472
109GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85378558
110RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84345551
111* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83808801
112PADI4_21655091_ChIP-ChIP_MCF-7_Human0.82596673
113* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82528211
114MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.81852367
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80493414
116* SOX2_16153702_ChIP-ChIP_HESCs_Human0.79799167
117BP1_19119308_ChIP-ChIP_Hs578T_Human0.79485706
118EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78662455
119ZNF263_19887448_ChIP-Seq_K562_Human0.78484187
120ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76977690
121ELF5_23300383_ChIP-Seq_T47D_Human0.74806231
122YY1_22570637_ChIP-Seq_MALME-3M_Human0.74507785

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.67710653
2MP0004957_abnormal_blastocyst_morpholog3.89615950
3MP0003111_abnormal_nucleus_morphology3.45382129
4MP0010094_abnormal_chromosome_stability3.38442015
5MP0003077_abnormal_cell_cycle3.28956881
6MP0006292_abnormal_olfactory_placode2.76305283
7MP0009379_abnormal_foot_pigmentation2.75408143
8MP0002277_abnormal_respiratory_mucosa2.66889049
9MP0002396_abnormal_hematopoietic_system2.58149045
10MP0008007_abnormal_cellular_replicative2.50041967
11MP0008057_abnormal_DNA_replication2.49034964
12MP0010352_gastrointestinal_tract_polyps2.45350989
13MP0006036_abnormal_mitochondrial_physio2.43651925
14MP0008058_abnormal_DNA_repair2.33453898
15MP0000490_abnormal_crypts_of2.16555499
16MP0008932_abnormal_embryonic_tissue2.14507179
17MP0000350_abnormal_cell_proliferation1.92861527
18MP0003136_yellow_coat_color1.87354058
19MP0001730_embryonic_growth_arrest1.84927644
20MP0009333_abnormal_splenocyte_physiolog1.80688894
21MP0003123_paternal_imprinting1.74812071
22MP0004808_abnormal_hematopoietic_stem1.72893414
23MP0003763_abnormal_thymus_physiology1.71465287
24MP0003786_premature_aging1.70523217
25MP0005397_hematopoietic_system_phenotyp1.57857256
26MP0001545_abnormal_hematopoietic_system1.57857256
27MP0003567_abnormal_fetal_cardiomyocyte1.52849648
28MP0006035_abnormal_mitochondrial_morpho1.52369802
29MP0006072_abnormal_retinal_apoptosis1.50683361
30MP0002160_abnormal_reproductive_system1.46355357
31MP0002019_abnormal_tumor_incidence1.45835260
32MP0010307_abnormal_tumor_latency1.44015761
33MP0002398_abnormal_bone_marrow1.41368682
34MP0010030_abnormal_orbit_morphology1.40272137
35MP0000313_abnormal_cell_death1.39531350
36MP0002163_abnormal_gland_morphology1.38465076
37MP0008995_early_reproductive_senescence1.37380393
38MP0001697_abnormal_embryo_size1.36794395
39MP0000703_abnormal_thymus_morphology1.36777485
40MP0006054_spinal_hemorrhage1.36594406
41MP0002722_abnormal_immune_system1.35336156
42MP0000372_irregular_coat_pigmentation1.34710924
43MP0002234_abnormal_pharynx_morphology1.34378931
44MP0002080_prenatal_lethality1.34264427
45MP0005084_abnormal_gallbladder_morpholo1.33868235
46MP0000685_abnormal_immune_system1.33338744
47MP0001764_abnormal_homeostasis1.32380376
48MP0003011_delayed_dark_adaptation1.32309916
49MP0001672_abnormal_embryogenesis/_devel1.31348461
50MP0005380_embryogenesis_phenotype1.31348461
51MP0003283_abnormal_digestive_organ1.29141239
52MP0000049_abnormal_middle_ear1.26204354
53MP0001905_abnormal_dopamine_level1.26038162
54MP0000689_abnormal_spleen_morphology1.24365486
55MP0004197_abnormal_fetal_growth/weight/1.24325832
56MP0000858_altered_metastatic_potential1.23942161
57MP0009278_abnormal_bone_marrow1.22829036
58MP0003984_embryonic_growth_retardation1.21975480
59MP0002085_abnormal_embryonic_tissue1.20223829
60MP0002088_abnormal_embryonic_growth/wei1.19686479
61MP0005389_reproductive_system_phenotype1.18314834
62MP0001835_abnormal_antigen_presentation1.16566154
63MP0002086_abnormal_extraembryonic_tissu1.16030233
64MP0002429_abnormal_blood_cell1.12552748
65MP0009697_abnormal_copulation1.12495038
66MP0002132_abnormal_respiratory_system1.12477813
67MP0005076_abnormal_cell_differentiation1.12221818
68MP0001800_abnormal_humoral_immune1.11876395
69MP0002084_abnormal_developmental_patter1.09860117
70MP0001919_abnormal_reproductive_system1.09795457
71MP0010155_abnormal_intestine_physiology1.06175455
72MP0005023_abnormal_wound_healing1.05846299
73MP0000566_synostosis1.05378746
74MP0000716_abnormal_immune_system1.04985207
75MP0004142_abnormal_muscle_tone1.02130875
76MP0001881_abnormal_mammary_gland1.00979812
77MP0005501_abnormal_skin_physiology0.99907435
78MP0003436_decreased_susceptibility_to0.98577815
79MP0002452_abnormal_antigen_presenting0.98549234
80MP0002420_abnormal_adaptive_immunity0.98536823
81MP0003938_abnormal_ear_development0.98356328
82MP0003941_abnormal_skin_development0.98166936
83MP0003315_abnormal_perineum_morphology0.97629928
84MP0001853_heart_inflammation0.97350614
85MP0001819_abnormal_immune_cell0.96983875
86MP0003705_abnormal_hypodermis_morpholog0.96905018
87MP0002405_respiratory_system_inflammati0.96009817
88MP0001293_anophthalmia0.95978030
89MP0000477_abnormal_intestine_morphology0.95027690
90MP0005174_abnormal_tail_pigmentation0.93328947
91MP0002166_altered_tumor_susceptibility0.92841128
92MP0000537_abnormal_urethra_morphology0.92137954
93MP0003186_abnormal_redox_activity0.91285928
94MP0001873_stomach_inflammation0.90853805
95MP0003566_abnormal_cell_adhesion0.90536260
96MP0005671_abnormal_response_to0.90023787
97MP0001346_abnormal_lacrimal_gland0.87519930
98MP0003718_maternal_effect0.86987522
99MP0009250_abnormal_appendicular_skeleto0.86504764
100MP0002723_abnormal_immune_serum0.85702163
101MP0000465_gastrointestinal_hemorrhage0.85070754
102MP0005025_abnormal_response_to0.84540072
103MP0002006_tumorigenesis0.84365174
104MP0009785_altered_susceptibility_to0.83571838
105MP0005000_abnormal_immune_tolerance0.82981127
106MP0004147_increased_porphyrin_level0.82537337
107MP0009053_abnormal_anal_canal0.81949087
108MP0004133_heterotaxia0.81029857
109MP0005408_hypopigmentation0.80764299
110MP0003806_abnormal_nucleotide_metabolis0.78690697
111MP0001849_ear_inflammation0.78104060
112MP0003866_abnormal_defecation0.77950205
113MP0001485_abnormal_pinna_reflex0.77632380
114MP0000358_abnormal_cell_content/0.77146929
115MP0002736_abnormal_nociception_after0.76642467
116MP0005645_abnormal_hypothalamus_physiol0.76495370
117MP0002111_abnormal_tail_morphology0.76249798
118MP0001529_abnormal_vocalization0.75506766
119MP0000631_abnormal_neuroendocrine_gland0.75339866
120MP0002653_abnormal_ependyma_morphology0.74227190
121MP0000762_abnormal_tongue_morphology0.73881826
122MP0000750_abnormal_muscle_regeneration0.73034227
123MP0002095_abnormal_skin_pigmentation0.71527319
124MP0005332_abnormal_amino_acid0.69890866
125MP0004947_skin_inflammation0.69717977
126MP0001286_abnormal_eye_development0.69560901
127MP0005377_hearing/vestibular/ear_phenot0.69333987
128MP0003878_abnormal_ear_physiology0.69333987
129MP0008789_abnormal_olfactory_epithelium0.67978011
130MP0003119_abnormal_digestive_system0.67695432
131MP0002210_abnormal_sex_determination0.67256809
132MP0002697_abnormal_eye_size0.67249860
133MP0005075_abnormal_melanosome_morpholog0.66782317
134MP0004019_abnormal_vitamin_homeostasis0.66740208
135MP0002938_white_spotting0.65767131
136MP0003448_altered_tumor_morphology0.64883465
137MP0000733_abnormal_muscle_development0.64542622
138MP0002148_abnormal_hypersensitivity_rea0.62614357
139MP0008872_abnormal_physiological_respon0.61857716
140MP0002638_abnormal_pupillary_reflex0.61640335
141MP0004742_abnormal_vestibular_system0.61537909
142MP0002837_dystrophic_cardiac_calcinosis0.60824799
143MP0001145_abnormal_male_reproductive0.60763088
144MP0009931_abnormal_skin_appearance0.59825735
145MP0001915_intracranial_hemorrhage0.59590319
146MP0003638_abnormal_response/metabolism_0.59136749
147MP0001663_abnormal_digestive_system0.59107316
148MP0000653_abnormal_sex_gland0.59088404
149MP0001216_abnormal_epidermal_layer0.58828740
150MP0005636_abnormal_mineral_homeostasis0.57373941

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.82715401
2Abnormal number of erythroid precursors (HP:0012131)7.25439345
3Reticulocytopenia (HP:0001896)7.17141126
4Acute necrotizing encephalopathy (HP:0006965)5.87763633
5Mitochondrial inheritance (HP:0001427)5.61420720
6Abnormal mitochondria in muscle tissue (HP:0008316)5.50874008
7Acute encephalopathy (HP:0006846)4.94707763
8Increased CSF lactate (HP:0002490)4.82731256
9* Macrocytic anemia (HP:0001972)4.73840559
10Renal Fanconi syndrome (HP:0001994)4.72933384
11Progressive macrocephaly (HP:0004481)4.67851960
12Hepatocellular necrosis (HP:0001404)4.60711888
13* Pallor (HP:0000980)4.51220274
14Hepatic necrosis (HP:0002605)4.13624566
153-Methylglutaconic aciduria (HP:0003535)4.08579194
16Cerebral edema (HP:0002181)3.94392231
17Increased muscle lipid content (HP:0009058)3.88918874
18Colon cancer (HP:0003003)3.64878103
19Thrombocytosis (HP:0001894)3.59297455
20Aplastic anemia (HP:0001915)3.33377187
21Oral leukoplakia (HP:0002745)3.28309089
22Lactic acidosis (HP:0003128)3.23620431
23Selective tooth agenesis (HP:0001592)3.19957188
24Increased serum lactate (HP:0002151)3.19807153
25Exercise intolerance (HP:0003546)3.14321411
26Birth length less than 3rd percentile (HP:0003561)3.06289725
27Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.02990401
28Respiratory failure (HP:0002878)2.99381240
29Multiple enchondromatosis (HP:0005701)2.98555381
30Trismus (HP:0000211)2.98280367
31Abnormality of renal resorption (HP:0011038)2.97173812
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.93985202
3311 pairs of ribs (HP:0000878)2.88298701
34Abnormality of reticulocytes (HP:0004312)2.81749725
35Absent thumb (HP:0009777)2.77804944
36Leukodystrophy (HP:0002415)2.75361367
37Breast hypoplasia (HP:0003187)2.68377161
38IgM deficiency (HP:0002850)2.58345158
39Rough bone trabeculation (HP:0100670)2.57668366
40Optic disc pallor (HP:0000543)2.47780734
41Patellar aplasia (HP:0006443)2.46863315
42Abnormal hemoglobin (HP:0011902)2.44420780
43Carpal bone hypoplasia (HP:0001498)2.40662498
44Lethargy (HP:0001254)2.38003529
45Aplasia/Hypoplasia of the patella (HP:0006498)2.36839565
46Microretrognathia (HP:0000308)2.36795639
47Glycosuria (HP:0003076)2.36611691
48Abnormality of urine glucose concentration (HP:0011016)2.36611691
49Hyperphosphaturia (HP:0003109)2.35220729
50Abnormality of the anterior horn cell (HP:0006802)2.29515315
51Degeneration of anterior horn cells (HP:0002398)2.29515315
52Neoplasm of the pancreas (HP:0002894)2.24545657
53Myelodysplasia (HP:0002863)2.21898659
54Microvesicular hepatic steatosis (HP:0001414)2.20102406
55Abnormal number of incisors (HP:0011064)2.19967844
56Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.19656881
57Basal cell carcinoma (HP:0002671)2.17191898
58Missing ribs (HP:0000921)2.15811273
59Decreased activity of mitochondrial respiratory chain (HP:0008972)2.15601089
60Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.15601089
61Methylmalonic aciduria (HP:0012120)2.15515104
62Abnormality of placental membranes (HP:0011409)2.13450446
63Amniotic constriction ring (HP:0009775)2.13450446
64Methylmalonic acidemia (HP:0002912)2.11108334
65Medulloblastoma (HP:0002885)2.10909050
66Petechiae (HP:0000967)2.07825609
67Premature graying of hair (HP:0002216)2.04631776
68Ependymoma (HP:0002888)2.03952612
69* Depressed nasal ridge (HP:0000457)2.03508755
70Atresia of the external auditory canal (HP:0000413)2.02981739
71Asplenia (HP:0001746)2.02564190
72Abnormality of the preputium (HP:0100587)2.01276336
73Chromsome breakage (HP:0040012)2.00635082
74Generalized aminoaciduria (HP:0002909)1.99625052
75Partial duplication of the phalanx of hand (HP:0009999)1.99509709
76Glossoptosis (HP:0000162)1.98753855
77Aplasia/Hypoplasia of the spleen (HP:0010451)1.97864329
78Meckel diverticulum (HP:0002245)1.95797613
79Abnormality of methionine metabolism (HP:0010901)1.95390400
80Triphalangeal thumb (HP:0001199)1.95329424
81Hypoplasia of the radius (HP:0002984)1.95242201
82Poikiloderma (HP:0001029)1.95208868
83Exertional dyspnea (HP:0002875)1.94935612
84Progressive muscle weakness (HP:0003323)1.94645894
85Abnormal urine phosphate concentration (HP:0012599)1.92442654
86Cellular immunodeficiency (HP:0005374)1.92363108
87Tracheoesophageal fistula (HP:0002575)1.90877181
88Abnormality of dicarboxylic acid metabolism (HP:0010995)1.90560054
89Dicarboxylic aciduria (HP:0003215)1.90560054
90Cleft eyelid (HP:0000625)1.89467218
91Renal tubular dysfunction (HP:0000124)1.87932047
92Increased hepatocellular lipid droplets (HP:0006565)1.87814012
93Lymphoma (HP:0002665)1.87027136
94Partial duplication of thumb phalanx (HP:0009944)1.86216164
95Abnormality of the ileum (HP:0001549)1.85965084
96Reduced antithrombin III activity (HP:0001976)1.85766532
97Elevated erythrocyte sedimentation rate (HP:0003565)1.85587673
98Septo-optic dysplasia (HP:0100842)1.83980191
99Hypoplasia of the pons (HP:0012110)1.82989983
100Agnosia (HP:0010524)1.82260358
101Megaloblastic anemia (HP:0001889)1.81775959
102Stenosis of the external auditory canal (HP:0000402)1.81570154
103Nasolacrimal duct obstruction (HP:0000579)1.80994190
104Abnormal trabecular bone morphology (HP:0100671)1.79782269
105Abnormality of T cell physiology (HP:0011840)1.78672062
106Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78255679
107* Thick lower lip vermilion (HP:0000179)1.77628803
108Abnormality of chromosome stability (HP:0003220)1.77071934
109Horseshoe kidney (HP:0000085)1.76789677
110Squamous cell carcinoma (HP:0002860)1.76707714
111Premature ovarian failure (HP:0008209)1.76423591
112CNS demyelination (HP:0007305)1.76337473
113Sparse eyelashes (HP:0000653)1.75518894
114Proximal placement of thumb (HP:0009623)1.75372464
115Bone marrow hypocellularity (HP:0005528)1.73648432
116Abnormality of the pons (HP:0007361)1.72518348
117Slender long bone (HP:0003100)1.72408178
118Amaurosis fugax (HP:0100576)1.72125187
119Absent radius (HP:0003974)1.71537975
120Rhabdomyosarcoma (HP:0002859)1.71329504
121Abnormality of aspartate family amino acid metabolism (HP:0010899)1.69477095
122Abnormality of serum amino acid levels (HP:0003112)1.69161375
123Type I transferrin isoform profile (HP:0003642)1.69126845
124Deviation of the thumb (HP:0009603)1.68016766
125Chromosomal breakage induced by crosslinking agents (HP:0003221)1.67811010
126Abnormality of T cells (HP:0002843)1.66639789
127Abnormality of the parietal bone (HP:0002696)1.66512591
128Pancytopenia (HP:0001876)1.65941460
129Maternal diabetes (HP:0009800)1.65550145
130IgG deficiency (HP:0004315)1.64092053
131Emotional lability (HP:0000712)1.63816058
132Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.63434558
133Abnormal protein N-linked glycosylation (HP:0012347)1.63434558
134Abnormal protein glycosylation (HP:0012346)1.63434558
135Abnormal glycosylation (HP:0012345)1.63434558
136Small intestinal stenosis (HP:0012848)1.62949500
137Duodenal stenosis (HP:0100867)1.62949500
138Aplasia/Hypoplasia of the thymus (HP:0010515)1.62891766
139Testicular atrophy (HP:0000029)1.62530272
140Cerebral hypomyelination (HP:0006808)1.61781368
141Neoplasm of the colon (HP:0100273)1.60811257
142Congenital ichthyosiform erythroderma (HP:0007431)1.59621247
143Lipid accumulation in hepatocytes (HP:0006561)1.59576748
144Overlapping toe (HP:0001845)1.59493198
145Redundant skin (HP:0001582)1.59061022
146Bilateral microphthalmos (HP:0007633)1.58165073
147X-linked dominant inheritance (HP:0001423)1.57487760
148Increased intramyocellular lipid droplets (HP:0012240)1.56576829
149Congenital, generalized hypertrichosis (HP:0004540)1.56545029
150Muscle fiber atrophy (HP:0100295)1.55949551
151Acute lymphatic leukemia (HP:0006721)1.55440207
152Abnormality of the heme biosynthetic pathway (HP:0010472)1.55234307
153Aplasia involving forearm bones (HP:0009822)1.55207973
154Absent forearm bone (HP:0003953)1.55207973
155Optic nerve coloboma (HP:0000588)1.54838829
156Rib fusion (HP:0000902)1.54807052
157Aplasia/Hypoplasia of the uvula (HP:0010293)1.54744253
158Neutropenia (HP:0001875)1.54558333
159Homocystinuria (HP:0002156)1.54441466
160Abnormality of homocysteine metabolism (HP:0010919)1.54441466
161Respiratory difficulties (HP:0002880)1.54332315
162* Migraine (HP:0002076)1.53430233
163Woolly hair (HP:0002224)1.52599193
164Rectal prolapse (HP:0002035)1.52256447
165Short thumb (HP:0009778)1.51588597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK27.08047709
2NME23.97099944
3BUB13.61592056
4WEE13.29893811
5EEF2K2.92005913
6CDC72.84165223
7TAF12.62199644
8ZAK2.52221923
9RPS6KB22.51974119
10EIF2AK12.40063220
11NEK22.29512329
12TESK22.23130147
13LRRK22.12210539
14MAP4K11.98088233
15TLK11.98052306
16PIM21.90722438
17SRPK11.84941030
18MAP3K101.83220362
19CDK71.70092655
20PKN21.68554207
21VRK11.66995180
22PASK1.65963126
23STK161.64723986
24RPS6KA41.58808170
25DYRK31.58764930
26NUAK11.56271111
27PBK1.55871606
28AURKB1.50155722
29PAK41.49142967
30TGFBR11.44506120
31TSSK61.42830725
32TTK1.41708464
33STK101.41625603
34SCYL21.35675912
35PLK11.35234768
36BRSK21.34741524
37MAP3K81.34323378
38EIF2AK31.33345969
39EPHA21.33078669
40SMG11.30179604
41MAP3K121.26990950
42PLK41.25901634
43MKNK11.25114096
44CDK41.24860289
45CDK121.23987231
46ATR1.22701401
47FLT31.18481893
48KDR1.17144243
49PDK21.16019343
50ACVR1B1.14863105
51ILK1.12113317
52ERN11.11692691
53DYRK21.11277376
54TRIB31.11163480
55PIM11.09947200
56MAPK151.09319600
57BTK1.08535772
58NEK11.06962035
59AURKA1.00098859
60TESK10.98613064
61MAPKAPK30.96836167
62TXK0.93038205
63MST40.92829367
64STK40.92499670
65MAP3K110.82993851
66CHEK10.81435093
67CHEK20.79753390
68BLK0.75461275
69PAK10.74966300
70TYK20.73508512
71ZAP700.72990756
72CSNK2A20.72190845
73CDK190.71624377
74MAP2K30.71260289
75MKNK20.70710149
76NME10.70474447
77GRK60.69961623
78MAPKAPK50.68365717
79ADRBK20.68326143
80TEC0.67803558
81CCNB10.66680467
82CDK60.65419586
83IKBKB0.64262546
84BRSK10.63925104
85LIMK10.60293326
86RPS6KA50.59502673
87CDK20.58849700
88CSNK2A10.58138487
89CSF1R0.58100897
90ALK0.57612795
91PRKCI0.55430102
92PLK30.55316546
93MAP2K20.55104696
94MYLK0.54835641
95KIT0.53831619
96TBK10.52347427
97JAK30.51412832
98EPHB20.50425947
99ATM0.50240556
100CDK80.49534256
101BRD40.49157275
102AKT20.46404055
103BCKDK0.46058135
104PAK20.44665425
105TAOK20.43493928
106TAOK30.43437343
107DAPK10.42209261
108RPS6KC10.41911273
109RPS6KL10.41911273
110EIF2AK20.41730131
111RPS6KA60.41259322
112MTOR0.40119989
113CHUK0.40097037
114SYK0.39585730
115BMPR1B0.38001655
116ARAF0.37517190
117DAPK30.37015034
118MAPKAPK20.36893038
119CLK10.36783578
120RPS6KA10.36441121
121PNCK0.36075329
122NLK0.36010784
123ABL20.35539005
124GRK10.33673955
125GRK50.32820058
126PRKCD0.32770881
127INSRR0.30925858
128MUSK0.28032655
129IKBKE0.26536313
130OXSR10.25671769
131CDK90.25489600
132ADRBK10.24779596
133ITK0.23329733
134LYN0.21525778
135CSNK1E0.21257044

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030106.32264994
2DNA replication_Homo sapiens_hsa030304.41950056
3Mismatch repair_Homo sapiens_hsa034303.66012821
4Spliceosome_Homo sapiens_hsa030403.19898877
5RNA polymerase_Homo sapiens_hsa030203.04287179
6Proteasome_Homo sapiens_hsa030503.02899789
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.85540863
8Base excision repair_Homo sapiens_hsa034102.68049061
9Homologous recombination_Homo sapiens_hsa034402.66423606
10RNA transport_Homo sapiens_hsa030132.54741657
11Nucleotide excision repair_Homo sapiens_hsa034202.52793160
12Pyrimidine metabolism_Homo sapiens_hsa002402.36217365
13One carbon pool by folate_Homo sapiens_hsa006702.20713210
14Cell cycle_Homo sapiens_hsa041102.00904289
15Cardiac muscle contraction_Homo sapiens_hsa042601.99925878
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93398945
17Fanconi anemia pathway_Homo sapiens_hsa034601.70461626
18RNA degradation_Homo sapiens_hsa030181.56104544
19Non-homologous end-joining_Homo sapiens_hsa034501.55418526
20p53 signaling pathway_Homo sapiens_hsa041151.48372141
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47345845
22mRNA surveillance pathway_Homo sapiens_hsa030151.29105001
23Basal transcription factors_Homo sapiens_hsa030221.28748482
24Epstein-Barr virus infection_Homo sapiens_hsa051691.14085092
25Sulfur relay system_Homo sapiens_hsa041221.11905728
26Systemic lupus erythematosus_Homo sapiens_hsa053221.11461918
27Primary immunodeficiency_Homo sapiens_hsa053401.08200183
28Antigen processing and presentation_Homo sapiens_hsa046121.07864428
29Parkinsons disease_Homo sapiens_hsa050121.05841443
30Purine metabolism_Homo sapiens_hsa002301.04408457
31Protein export_Homo sapiens_hsa030601.02943111
32Pentose phosphate pathway_Homo sapiens_hsa000301.02306589
33Herpes simplex infection_Homo sapiens_hsa051681.00627275
34Huntingtons disease_Homo sapiens_hsa050160.95054696
35Oxidative phosphorylation_Homo sapiens_hsa001900.89759324
36Viral carcinogenesis_Homo sapiens_hsa052030.86207323
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84780411
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81353545
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79780650
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78408634
41Folate biosynthesis_Homo sapiens_hsa007900.77126246
42HTLV-I infection_Homo sapiens_hsa051660.76636976
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73162155
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.72646574
45Vitamin digestion and absorption_Homo sapiens_hsa049770.72064455
46Legionellosis_Homo sapiens_hsa051340.71013202
47Small cell lung cancer_Homo sapiens_hsa052220.68394807
48Thyroid cancer_Homo sapiens_hsa052160.66150181
49Pyruvate metabolism_Homo sapiens_hsa006200.65359028
50Apoptosis_Homo sapiens_hsa042100.63656244
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.63320632
52Measles_Homo sapiens_hsa051620.62111262
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60230539
54Sulfur metabolism_Homo sapiens_hsa009200.60087537
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.59123919
56Shigellosis_Homo sapiens_hsa051310.58985844
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57709486
58Acute myeloid leukemia_Homo sapiens_hsa052210.57641620
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56914250
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.55858465
61Glutathione metabolism_Homo sapiens_hsa004800.55532751
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54711061
63Hematopoietic cell lineage_Homo sapiens_hsa046400.54427076
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53811797
65Autoimmune thyroid disease_Homo sapiens_hsa053200.53591494
66Notch signaling pathway_Homo sapiens_hsa043300.52145470
67Chronic myeloid leukemia_Homo sapiens_hsa052200.51554981
68Bladder cancer_Homo sapiens_hsa052190.51118903
69N-Glycan biosynthesis_Homo sapiens_hsa005100.50799264
70Biosynthesis of amino acids_Homo sapiens_hsa012300.50768759
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50613921
72MicroRNAs in cancer_Homo sapiens_hsa052060.50182973
73Leishmaniasis_Homo sapiens_hsa051400.48921789
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48706177
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.48145700
76Graft-versus-host disease_Homo sapiens_hsa053320.47934766
77Chemical carcinogenesis_Homo sapiens_hsa052040.47197842
78Alzheimers disease_Homo sapiens_hsa050100.47023492
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45998887
80Hepatitis B_Homo sapiens_hsa051610.44753037
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44150135
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42789500
83Tyrosine metabolism_Homo sapiens_hsa003500.42239091
84Basal cell carcinoma_Homo sapiens_hsa052170.41800898
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40021094
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.39165582
87B cell receptor signaling pathway_Homo sapiens_hsa046620.38629096
88Peroxisome_Homo sapiens_hsa041460.38307491
89Selenocompound metabolism_Homo sapiens_hsa004500.38171885
90Collecting duct acid secretion_Homo sapiens_hsa049660.37800912
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37508979
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35542261
93Influenza A_Homo sapiens_hsa051640.35233769
94Viral myocarditis_Homo sapiens_hsa054160.34307260
95HIF-1 signaling pathway_Homo sapiens_hsa040660.33703978
96Colorectal cancer_Homo sapiens_hsa052100.33108922
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33026965
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.31042756
99TGF-beta signaling pathway_Homo sapiens_hsa043500.30638081
100Carbon metabolism_Homo sapiens_hsa012000.30628477
101Fatty acid elongation_Homo sapiens_hsa000620.30572359
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.30422137
103Retinol metabolism_Homo sapiens_hsa008300.29525330
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28936175
105Oocyte meiosis_Homo sapiens_hsa041140.28872744
106Arachidonic acid metabolism_Homo sapiens_hsa005900.28251945
107Toxoplasmosis_Homo sapiens_hsa051450.27982189
108Pathways in cancer_Homo sapiens_hsa052000.27925592
109Caffeine metabolism_Homo sapiens_hsa002320.27613706
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27579987
111Fructose and mannose metabolism_Homo sapiens_hsa000510.27457081
112Asthma_Homo sapiens_hsa053100.26708250
113Rheumatoid arthritis_Homo sapiens_hsa053230.25698219
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.24558552
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23983176
116Hippo signaling pathway_Homo sapiens_hsa043900.23950833
117Alcoholism_Homo sapiens_hsa050340.23442446
118Galactose metabolism_Homo sapiens_hsa000520.23344114
119Allograft rejection_Homo sapiens_hsa053300.21908797
120Type I diabetes mellitus_Homo sapiens_hsa049400.21330463
121Tryptophan metabolism_Homo sapiens_hsa003800.21050875
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20336936
123Linoleic acid metabolism_Homo sapiens_hsa005910.19493686
124T cell receptor signaling pathway_Homo sapiens_hsa046600.19050713
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18542553
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18535594
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18401189
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.18339431
129Phenylalanine metabolism_Homo sapiens_hsa003600.17937701
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.17855950
131Metabolic pathways_Homo sapiens_hsa011000.17368307
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16622687
133Fat digestion and absorption_Homo sapiens_hsa049750.14488755
134Propanoate metabolism_Homo sapiens_hsa006400.14109227
135Hedgehog signaling pathway_Homo sapiens_hsa043400.14012510
136Regulation of autophagy_Homo sapiens_hsa041400.12155843
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12055172
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11979717
139Phototransduction_Homo sapiens_hsa047440.10831294
140Fatty acid degradation_Homo sapiens_hsa000710.10523194
141Mineral absorption_Homo sapiens_hsa049780.09682225
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.08081220
143Nitrogen metabolism_Homo sapiens_hsa009100.06315142
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.05804135

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