ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cytidine metabolic process (GO:0046087)	8.89765220
2	cytidine catabolic process (GO:0006216)	8.89765220
3	cytidine deamination (GO:0009972)	8.89765220
4	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	8.85753769
5	pyrimidine ribonucleoside catabolic process (GO:0046133)	8.00877974
6	Arp2/3 complex-mediated actin nucleation (GO:0034314)	4.23780784
7	pyrimidine nucleoside catabolic process (GO:0046135)	4.03937488
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.93774678
9	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.91771343
10	ATP synthesis coupled proton transport (GO:0015986)	3.91771343
11	actin nucleation (GO:0045010)	3.86466265
12	positive thymic T cell selection (GO:0045059)	3.72087987
13	negative T cell selection (GO:0043383)	3.68581308
14	positive T cell selection (GO:0043368)	3.68214538
15	behavioral response to nicotine (GO:0035095)	3.65962303
16	positive regulation of prostaglandin secretion (GO:0032308)	3.56474930
17	proteasome assembly (GO:0043248)	3.55381740
18	protein neddylation (GO:0045116)	3.53031395
19	ribosomal small subunit assembly (GO:0000028)	3.49656381
20	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.46893662
21	positive regulation of defense response to virus by host (GO:0002230)	3.40633347
22	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.34662698
23	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.34038331
24	negative regulation of T cell apoptotic process (GO:0070233)	3.33505631
25	regulation of regulatory T cell differentiation (GO:0045589)	3.29692921
26	negative regulation of viral genome replication (GO:0045071)	3.27839352
27	sequestering of actin monomers (GO:0042989)	3.24863592
28	T cell migration (GO:0072678)	3.24318520
29	positive regulation of interleukin-8 secretion (GO:2000484)	3.24228504
30	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.23019569
31	positive regulation of fatty acid transport (GO:2000193)	3.20872722
32	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.20192964
33	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.20192964
34	negative regulation of mast cell activation (GO:0033004)	3.19292116
35	cellular response to interleukin-15 (GO:0071350)	3.18817960
36	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.18778498
37	positive regulation of tolerance induction (GO:0002645)	3.14560558
38	regulation of T cell receptor signaling pathway (GO:0050856)	3.14530479
39	negative regulation by host of viral transcription (GO:0043922)	3.14063752
40	DNA demethylation (GO:0080111)	3.13137105
41	respiratory electron transport chain (GO:0022904)	3.10535003
42	electron transport chain (GO:0022900)	3.09325435
43	maturation of SSU-rRNA (GO:0030490)	3.09104648
44	negative thymic T cell selection (GO:0045060)	3.07526247
45	regulation of B cell receptor signaling pathway (GO:0050855)	3.06420740
46	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.06371731
47	positive regulation of calcium-mediated signaling (GO:0050850)	3.05463979
48	positive regulation of protein homodimerization activity (GO:0090073)	3.05081136
49	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.99155809
50	protein-cofactor linkage (GO:0018065)	2.97766083
51	regulation of chronic inflammatory response (GO:0002676)	2.96017752
52	platelet dense granule organization (GO:0060155)	2.95421120
53	negative regulation of telomere maintenance (GO:0032205)	2.94587711
54	positive regulation of cell killing (GO:0031343)	2.90144392
55	regulation of activation of Janus kinase activity (GO:0010533)	2.88740263
56	regulation of isotype switching to IgG isotypes (GO:0048302)	2.85988242
57	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.85718615
58	thymic T cell selection (GO:0045061)	2.84055826
59	regulation of cellular amino acid metabolic process (GO:0006521)	2.81810551
60	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.81650238
61	regulation of uterine smooth muscle contraction (GO:0070472)	2.81568564
62	positive regulation of icosanoid secretion (GO:0032305)	2.80512371
63	regulation of prostaglandin secretion (GO:0032306)	2.80207486
64	chaperone-mediated protein transport (GO:0072321)	2.79840533
65	regulation of natural killer cell mediated immunity (GO:0002715)	2.79555361
66	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	2.79555361
67	cytolysis (GO:0019835)	2.77838303
68	response to interferon-beta (GO:0035456)	2.77645516
69	pyrimidine-containing compound catabolic process (GO:0072529)	2.77592592
70	negative regulation of B cell apoptotic process (GO:0002903)	2.76481355
71	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.76283283
72	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.75631485
73	regulation of T cell tolerance induction (GO:0002664)	2.74301846
74	rRNA modification (GO:0000154)	2.72301970
75	DNA dealkylation (GO:0035510)	2.71699766
76	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.71531101
77	T cell receptor signaling pathway (GO:0050852)	2.71265332
78	metallo-sulfur cluster assembly (GO:0031163)	2.69206609
79	iron-sulfur cluster assembly (GO:0016226)	2.69206609
80	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.66497131
81	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.64932105
82	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.63642308
83	regulation of T cell chemotaxis (GO:0010819)	2.63177082
84	positive regulation of T cell chemotaxis (GO:0010820)	2.63177082
85	regulation of cell killing (GO:0031341)	2.62728462
86	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.61592052
87	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.61592052
88	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.61592052
89	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.61262609
90	protein complex biogenesis (GO:0070271)	2.60653963
91	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.59460955
92	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.59460955
93	S-adenosylmethionine metabolic process (GO:0046500)	2.57555410
94	mast cell activation (GO:0045576)	2.57242259
95	mast cell activation involved in immune response (GO:0002279)	2.57200343
96	mast cell degranulation (GO:0043303)	2.57200343
97	sulfation (GO:0051923)	2.57155036
98	regulation of T cell mediated cytotoxicity (GO:0001914)	2.55622744
99	ubiquinone biosynthetic process (GO:0006744)	2.53242451
100	DNA deamination (GO:0045006)	10.0050396

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.84473980
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.36526419
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.34993898
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.31581935
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.98145833
6	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.91934558
7	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.86857287
8	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.72467964
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.63805292
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.61987801
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.51428687
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.47607860
13	VDR_22108803_ChIP-Seq_LS180_Human	2.46176587
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.39913467
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.39441326
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.35711535
17	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.19549169
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.07847531
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.06708556
20	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.99048102
21	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.98219754
22	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.94293386
23	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.93810299
24	EZH2_22144423_ChIP-Seq_EOC_Human	1.91660810
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.89706143
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.87810461
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.80794512
28	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.69165257
29	MYB_26560356_Chip-Seq_TH2_Human	1.64338299
30	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.63095341
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62747163
32	GATA3_26560356_Chip-Seq_TH2_Human	1.62287284
33	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.61180039
34	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.54252779
35	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.52638739
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.52247930
37	IGF1R_20145208_ChIP-Seq_DFB_Human	1.51543121
38	NCOR_22424771_ChIP-Seq_293T_Human	1.49948367
39	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.47632462
40	ELK1_19687146_ChIP-ChIP_HELA_Human	1.46162668
41	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.44658025
42	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.40611022
43	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.39470264
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35483595
45	MYC_18940864_ChIP-ChIP_HL60_Human	1.35482822
46	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.33541320
47	EWS_26573619_Chip-Seq_HEK293_Human	1.29978586
48	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.28562718
49	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.28494548
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.27986371
51	IRF1_19129219_ChIP-ChIP_H3396_Human	1.26241863
52	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.25253334
53	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.21983205
54	RUNX_20019798_ChIP-Seq_JUKART_Human	1.21870719
55	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.21507274
56	NANOG_20526341_ChIP-Seq_ESCs_Human	1.20387719
57	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19367253
58	* GATA3_27048872_Chip-Seq_THYMUS_Human	1.17839291
59	TAF2_19829295_ChIP-Seq_ESCs_Human	1.15426907
60	MYC_19829295_ChIP-Seq_ESCs_Human	1.14065861
61	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.12976786
62	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12857635
63	ERA_21632823_ChIP-Seq_H3396_Human	1.11695323
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11372622
65	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11372622
66	AR_20517297_ChIP-Seq_VCAP_Human	1.09728747
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09034258
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09034258
69	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.08072980
70	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.05371039
71	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04359973
72	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.04019194
73	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02343715
74	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01413864
75	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.99980962
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98391850
77	HOXB7_26014856_ChIP-Seq_BT474_Human	0.98334019
78	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.97642653
79	* BCL6_27268052_Chip-Seq_Bcells_Human	0.96839139
80	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.96746950
81	CBP_20019798_ChIP-Seq_JUKART_Human	0.96746950
82	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.96102232
83	GBX2_23144817_ChIP-Seq_PC3_Human	0.94876158
84	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.94727227
85	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.94712824
86	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.94501425
87	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.94113372
88	ER_23166858_ChIP-Seq_MCF-7_Human	0.94095279
89	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.93334776
90	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.92363290
91	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.90441820
92	OCT4_20526341_ChIP-Seq_ESCs_Human	0.90302729
93	MYB_26560356_Chip-Seq_TH1_Human	0.89838787
94	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.89779852
95	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.89645904
96	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.89005928
97	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.87879142
98	RBPJ_21746931_ChIP-Seq_IB4_Human	0.87566156
99	* CTCF_20526341_ChIP-Seq_ESCs_Human	0.87133823
100	CIITA_25753668_ChIP-Seq_RAJI_Human	0.85743041

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.76158082
2	MP0004147_increased_porphyrin_level	3.22776282
3	MP0001835_abnormal_antigen_presentation	2.78067029
4	MP0003646_muscle_fatigue	2.77771407
5	MP0003763_abnormal_thymus_physiology	2.68057670
6	MP0000685_abnormal_immune_system	2.66348501
7	MP0009785_altered_susceptibility_to	2.57741997
8	MP0002138_abnormal_hepatobiliary_system	2.08977231
9	MP0008877_abnormal_DNA_methylation	2.04744616
10	MP0001873_stomach_inflammation	2.02304543
11	MP0005000_abnormal_immune_tolerance	1.97394736
12	MP0003786_premature_aging	1.95444909
13	MP0001188_hyperpigmentation	1.88390558
14	MP0000569_abnormal_digit_pigmentation	1.86636127
15	MP0001800_abnormal_humoral_immune	1.85031945
16	MP0009333_abnormal_splenocyte_physiolog	1.83249534
17	MP0003866_abnormal_defecation	1.81374541
18	MP0002148_abnormal_hypersensitivity_rea	1.79067420
19	MP0001905_abnormal_dopamine_level	1.79059710
20	MP0002420_abnormal_adaptive_immunity	1.75955827
21	MP0006072_abnormal_retinal_apoptosis	1.72981932
22	MP0002876_abnormal_thyroid_physiology	1.70433354
23	MP0005075_abnormal_melanosome_morpholog	1.70417493
24	MP0008872_abnormal_physiological_respon	1.70069149
25	MP0002736_abnormal_nociception_after	1.69317816
26	MP0001819_abnormal_immune_cell	1.68675271
27	MP0006292_abnormal_olfactory_placode	1.68523649
28	MP0001661_extended_life_span	1.68395442
29	MP0002723_abnormal_immune_serum	1.67270675
30	MP0005551_abnormal_eye_electrophysiolog	1.66636950
31	MP0005025_abnormal_response_to	1.61632714
32	MP0009379_abnormal_foot_pigmentation	1.61593138
33	MP0002822_catalepsy	1.60015404
34	MP0005387_immune_system_phenotype	1.58712665
35	MP0001790_abnormal_immune_system	1.58712665
36	MP0001968_abnormal_touch/_nociception	1.57580844
37	MP0004885_abnormal_endolymph	1.53952322
38	MP0002166_altered_tumor_susceptibility	1.53765499
39	MP0002006_tumorigenesis	1.52708233
40	MP0005645_abnormal_hypothalamus_physiol	1.50986225
41	MP0004145_abnormal_muscle_electrophysio	1.50701947
42	MP0003195_calcinosis	1.49285860
43	MP0001501_abnormal_sleep_pattern	1.49021024
44	MP0000703_abnormal_thymus_morphology	1.44627365
45	MP0002234_abnormal_pharynx_morphology	1.39847474
46	MP0003806_abnormal_nucleotide_metabolis	1.39391523
47	MP0001919_abnormal_reproductive_system	1.35753798
48	MP0003880_abnormal_central_pattern	1.35069468
49	MP0000716_abnormal_immune_system	1.34813647
50	MP0002398_abnormal_bone_marrow	1.34546361
51	MP0006082_CNS_inflammation	1.34473573
52	MP0008995_early_reproductive_senescence	1.33826534
53	MP0008875_abnormal_xenobiotic_pharmacok	1.29513515
54	MP0002452_abnormal_antigen_presenting	1.26909467
55	MP0002277_abnormal_respiratory_mucosa	1.26563063
56	MP0005389_reproductive_system_phenotype	1.25367476
57	MP0001542_abnormal_bone_strength	1.24819338
58	MP0002735_abnormal_chemical_nociception	1.24446285
59	MP0002405_respiratory_system_inflammati	1.23839469
60	MP0004142_abnormal_muscle_tone	1.22498497
61	MP0009745_abnormal_behavioral_response	1.21882954
62	MP0009764_decreased_sensitivity_to	1.20946921
63	MP0002722_abnormal_immune_system	1.19404798
64	MP0000372_irregular_coat_pigmentation	1.18990832
65	MP0009046_muscle_twitch	1.18925436
66	MP0000689_abnormal_spleen_morphology	1.17254320
67	MP0006276_abnormal_autonomic_nervous	1.15812916
68	MP0005084_abnormal_gallbladder_morpholo	1.15714872
69	MP0002272_abnormal_nervous_system	1.13933013
70	MP0003011_delayed_dark_adaptation	1.12320214
71	MP0002095_abnormal_skin_pigmentation	1.08297776
72	MP0008007_abnormal_cellular_replicative	1.04690856
73	MP0002163_abnormal_gland_morphology	1.04324328
74	MP0001845_abnormal_inflammatory_respons	1.03440045
75	MP0010155_abnormal_intestine_physiology	0.98290070
76	MP0002837_dystrophic_cardiac_calcinosis	0.97483250
77	MP0005253_abnormal_eye_physiology	0.97066369
78	MP0002429_abnormal_blood_cell	0.96888201
79	MP0002102_abnormal_ear_morphology	0.94474732
80	MP0002733_abnormal_thermal_nociception	0.93095260
81	MP0001970_abnormal_pain_threshold	0.85962317
82	MP0001986_abnormal_taste_sensitivity	0.85707462
83	MP0004043_abnormal_pH_regulation	0.82332776
84	MP0003436_decreased_susceptibility_to	0.80956102
85	MP0002160_abnormal_reproductive_system	0.76509944
86	MP0008789_abnormal_olfactory_epithelium	0.75493403
87	MP0002419_abnormal_innate_immunity	0.74684623
88	MP0005174_abnormal_tail_pigmentation	0.74404680
89	MP0000613_abnormal_salivary_gland	0.74210930
90	MP0002693_abnormal_pancreas_physiology	0.72869450
91	MP0008469_abnormal_protein_level	0.72308654
92	MP0005423_abnormal_somatic_nervous	0.72238618
93	MP0005646_abnormal_pituitary_gland	0.71249524
94	MP0008873_increased_physiological_sensi	0.70609515
95	MP0006036_abnormal_mitochondrial_physio	0.69642459
96	MP0001663_abnormal_digestive_system	0.65926992
97	MP0003448_altered_tumor_morphology	0.65524216
98	MP0001529_abnormal_vocalization	0.64577049
99	MP0005360_urolithiasis	0.64334512
100	MP0005410_abnormal_fertilization	0.63257633

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	4.24057217
2	Severe combined immunodeficiency (HP:0004430)	3.90121376
3	Pancreatic cysts (HP:0001737)	3.82578118
4	Mitochondrial inheritance (HP:0001427)	3.75234050
5	Aplastic anemia (HP:0001915)	3.71399110
6	Pancreatic fibrosis (HP:0100732)	3.66304111
7	T lymphocytopenia (HP:0005403)	3.60088140
8	Abnormality of T cell number (HP:0011839)	3.58225515
9	Increased hepatocellular lipid droplets (HP:0006565)	3.57421542
10	Hepatocellular necrosis (HP:0001404)	3.41601099
11	Lipid accumulation in hepatocytes (HP:0006561)	3.37460192
12	Thyroiditis (HP:0100646)	3.32683272
13	Increased intramyocellular lipid droplets (HP:0012240)	3.30665183
14	Acute necrotizing encephalopathy (HP:0006965)	3.29344243
15	Increased CSF lactate (HP:0002490)	3.28413247
16	Renal Fanconi syndrome (HP:0001994)	3.27292565
17	Abnormality of eosinophils (HP:0001879)	3.26507917
18	Abnormality of midbrain morphology (HP:0002418)	3.24241445
19	Molar tooth sign on MRI (HP:0002419)	3.24241445
20	Increased IgM level (HP:0003496)	3.16396915
21	Hepatic necrosis (HP:0002605)	3.13819498
22	Abnormal mitochondria in muscle tissue (HP:0008316)	3.10486439
23	Congenital stationary night blindness (HP:0007642)	3.06090428
24	Autoimmune hemolytic anemia (HP:0001890)	2.97895674
25	Congenital, generalized hypertrichosis (HP:0004540)	2.97113763
26	Combined immunodeficiency (HP:0005387)	2.96041969
27	True hermaphroditism (HP:0010459)	2.89315980
28	Abnormality of B cell number (HP:0010975)	2.87997520
29	Hypoproteinemia (HP:0003075)	2.87318206
30	Abolished electroretinogram (ERG) (HP:0000550)	2.82550157
31	Increased muscle lipid content (HP:0009058)	2.80736780
32	Elevated erythrocyte sedimentation rate (HP:0003565)	2.78390233
33	Acute encephalopathy (HP:0006846)	2.72422324
34	Progressive macrocephaly (HP:0004481)	2.68664263
35	Eosinophilia (HP:0001880)	2.65467476
36	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.60092356
37	Abnormality of T cells (HP:0002843)	2.58747936
38	3-Methylglutaconic aciduria (HP:0003535)	2.57620654
39	Abnormality of the prostate (HP:0008775)	2.56959110
40	Increased serum lactate (HP:0002151)	2.54884581
41	Type 2 muscle fiber atrophy (HP:0003554)	2.45853678
42	Abnormality of the renal cortex (HP:0011035)	2.40726422
43	B lymphocytopenia (HP:0010976)	2.39759077
44	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.38653480
45	Generalized aminoaciduria (HP:0002909)	2.34163325
46	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.32153813
47	Cerebral edema (HP:0002181)	2.30331847
48	Attenuation of retinal blood vessels (HP:0007843)	2.27625686
49	Pancytopenia (HP:0001876)	2.25752229
50	Optic disc pallor (HP:0000543)	2.24293279
51	Renal cortical cysts (HP:0000803)	2.23481690
52	Exertional dyspnea (HP:0002875)	2.18614448
53	Cystic liver disease (HP:0006706)	2.18448570
54	Abnormal rod and cone electroretinograms (HP:0008323)	2.18116184
55	Hypoplasia of the pons (HP:0012110)	2.15569539
56	Muscle fiber atrophy (HP:0100295)	2.14634175
57	Stomatitis (HP:0010280)	2.12159536
58	Polydipsia (HP:0001959)	2.11512846
59	Abnormal drinking behavior (HP:0030082)	2.11512846
60	Chronic mucocutaneous candidiasis (HP:0002728)	2.10241979
61	Recurrent cutaneous fungal infections (HP:0011370)	2.10241979
62	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.08220929
63	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.08220929
64	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.07771467
65	Lactic acidosis (HP:0003128)	2.06813040
66	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.04974043
67	Abnormality of alanine metabolism (HP:0010916)	2.04974043
68	Hyperalaninemia (HP:0003348)	2.04974043
69	Polyuria (HP:0000103)	2.04672655
70	Chronic hepatic failure (HP:0100626)	2.03875296
71	Prostate neoplasm (HP:0100787)	2.01505637
72	Type I transferrin isoform profile (HP:0003642)	1.98048528
73	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.97194870
74	Abnormality of the pons (HP:0007361)	1.97156507
75	Chorioretinal atrophy (HP:0000533)	1.96647512
76	Sclerocornea (HP:0000647)	1.95780645
77	Hypoplasia of the thymus (HP:0000778)	1.95307734
78	Constricted visual fields (HP:0001133)	1.95068204
79	Absent thumb (HP:0009777)	1.94088701
80	Abnormality of renal resorption (HP:0011038)	1.93217877
81	Abnormality of urine glucose concentration (HP:0011016)	1.93125072
82	Glycosuria (HP:0003076)	1.93125072
83	Medial flaring of the eyebrow (HP:0010747)	1.90617017
84	Encephalitis (HP:0002383)	1.89964780
85	Nephronophthisis (HP:0000090)	1.88601594
86	Leukocytosis (HP:0001974)	1.88516302
87	Abnormal number of erythroid precursors (HP:0012131)	1.87888492
88	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.87073561
89	Hypomagnesemia (HP:0002917)	1.86447282
90	Pendular nystagmus (HP:0012043)	1.84959327
91	Recurrent bronchitis (HP:0002837)	1.83866442
92	Amyotrophic lateral sclerosis (HP:0007354)	1.83712112
93	Granulocytopenia (HP:0001913)	1.83228738
94	Hemiplegia (HP:0002301)	1.79691754
95	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.79540751
96	Decreased central vision (HP:0007663)	1.78194729
97	Asplenia (HP:0001746)	1.77799596
98	Abnormality of the renal medulla (HP:0100957)	1.76556494
99	Abnormality of magnesium homeostasis (HP:0004921)	1.76492009
100	Agammaglobulinemia (HP:0004432)	1.74124089

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	KDR	4.46238616
2	TXK	3.43980391
3	TESK2	3.17015931
4	TLK1	3.04653854
5	BCKDK	3.02938568
6	ZAK	2.97596297
7	VRK2	2.51495928
8	TAOK3	2.37314188
9	GRK1	2.23096823
10	LIMK1	2.16199302
11	MUSK	2.09575271
12	ADRBK2	1.98976620
13	ITK	1.88527943
14	MAP4K1	1.87927831
15	KIT	1.76102760
16	FRK	1.74550416
17	GRK6	1.66198199
18	NUAK1	1.65585935
19	VRK1	1.57888205
20	SYK	1.57701950
21	WNK4	1.56210599
22	PLK2	1.53916496
23	FES	1.53286415
24	MAPKAPK3	1.49686668
25	EIF2AK3	1.42661128
26	TAF1	1.40717226
27	TESK1	1.29455775
28	BUB1	1.28685165
29	NME1	1.24556461
30	BMPR1B	1.20331627
31	MAP3K12	1.18208427
32	CAMKK2	1.16463676
33	PRKCQ	1.13156802
34	LCK	1.08268789
35	IKBKB	1.07992525
36	PIM2	1.06263047
37	BTK	1.05504777
38	MAP3K11	1.05362855
39	TIE1	1.04600052
40	MAP4K2	1.02993406
41	ZAP70	1.02102086
42	NTRK2	1.00258068
43	TEC	0.99962895
44	PHKG2	0.96080802
45	PHKG1	0.96080802
46	MST4	0.95222042
47	MAPK13	0.92387103
48	OXSR1	0.90001666
49	LYN	0.81241197
50	CSK	0.79308949
51	IKBKE	0.74172167
52	WNK3	0.73714316
53	INSRR	0.72669945
54	MAPKAPK5	0.68440166
55	MAP2K7	0.68368082
56	DYRK2	0.67844400
57	PASK	0.66932061
58	RPS6KA5	0.65155828
59	CAMKK1	0.64873540
60	SCYL2	0.64650883
61	STK16	0.64051565
62	CSNK1G3	0.62637266
63	DAPK1	0.60342730
64	PRKCI	0.59543059
65	ADRBK1	0.59071838
66	NTRK1	0.58864446
67	CSF1R	0.56470755
68	CSNK1G2	0.56469952
69	OBSCN	0.49972453
70	IGF1R	0.49239675
71	PINK1	0.48631292
72	CAMK2A	0.47292413
73	MYLK	0.46626462
74	ATR	0.45962605
75	NTRK3	0.45778288
76	PRKD3	0.45712181
77	NEK1	0.45408214
78	TSSK6	0.44912863
79	DAPK2	0.44893608
80	PRKCA	0.44628468
81	PIM1	0.42312082
82	PRKACA	0.41967979
83	SRPK1	0.41743856
84	PRKCE	0.41296921
85	CSNK1G1	0.38383863
86	PRKCH	0.37564069
87	JAK3	0.36978165
88	DAPK3	0.35160585
89	CSNK1A1L	0.34564863
90	ACVR1B	0.34341575
91	EPHB2	0.34097960
92	GRK7	0.32038658
93	MATK	0.31426717
94	HCK	0.31354178
95	PRKCD	0.30786356
96	CSNK2A1	0.29949261
97	GRK5	0.29448275
98	PLK3	0.28940089
99	PIK3CA	0.27932113
100	TNK2	0.27615824

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	4.55152675
2	Proteasome_Homo sapiens_hsa03050	3.92748865
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.55876321
4	Parkinsons disease_Homo sapiens_hsa05012	3.15199638
5	Graft-versus-host disease_Homo sapiens_hsa05332	2.81680171
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.60938799
7	Allograft rejection_Homo sapiens_hsa05330	2.57653353
8	RNA polymerase_Homo sapiens_hsa03020	2.30336627
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.29219384
10	Antigen processing and presentation_Homo sapiens_hsa04612	2.25367160
11	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.17514120
12	Ribosome_Homo sapiens_hsa03010	2.14803942
13	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.12586369
14	Phototransduction_Homo sapiens_hsa04744	2.01930922
15	Alzheimers disease_Homo sapiens_hsa05010	1.95011357
16	Huntingtons disease_Homo sapiens_hsa05016	1.90818901
17	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.90732872
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.83586583
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.83260833
20	Asthma_Homo sapiens_hsa05310	1.77828694
21	Protein export_Homo sapiens_hsa03060	1.76320607
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.70186771
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.57418052
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.56681970
25	Homologous recombination_Homo sapiens_hsa03440	1.43924260
26	Rheumatoid arthritis_Homo sapiens_hsa05323	1.40607951
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.39807808
28	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.39314947
29	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.35151374
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.30723687
31	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.29416174
32	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.21438195
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.21365917
34	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.19548348
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.17938281
36	RNA degradation_Homo sapiens_hsa03018	1.11115978
37	Fanconi anemia pathway_Homo sapiens_hsa03460	1.10399044
38	Basal transcription factors_Homo sapiens_hsa03022	1.06520640
39	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.03799913
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.00374524
41	Nicotine addiction_Homo sapiens_hsa05033	0.94569015
42	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.93274390
43	Caffeine metabolism_Homo sapiens_hsa00232	0.91737234
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.89899420
45	Purine metabolism_Homo sapiens_hsa00230	0.89184042
46	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.88328315
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.84655829
48	Viral myocarditis_Homo sapiens_hsa05416	0.83095691
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.82169743
50	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.82134665
51	Butanoate metabolism_Homo sapiens_hsa00650	0.80902388
52	Peroxisome_Homo sapiens_hsa04146	0.73419409
53	Propanoate metabolism_Homo sapiens_hsa00640	0.71786116
54	Olfactory transduction_Homo sapiens_hsa04740	0.68553193
55	Shigellosis_Homo sapiens_hsa05131	0.67049208
56	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.65771357
57	Nucleotide excision repair_Homo sapiens_hsa03420	0.64882894
58	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.63954633
59	Spliceosome_Homo sapiens_hsa03040	0.62898945
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61472126
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.60480467
62	Measles_Homo sapiens_hsa05162	0.59970655
63	Mismatch repair_Homo sapiens_hsa03430	0.59126249
64	Morphine addiction_Homo sapiens_hsa05032	0.58092147
65	DNA replication_Homo sapiens_hsa03030	0.55206300
66	Tryptophan metabolism_Homo sapiens_hsa00380	0.54922689
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54604524
68	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.51852513
69	Regulation of autophagy_Homo sapiens_hsa04140	0.51610638
70	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.51305418
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.51227948
72	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50452897
73	Salmonella infection_Homo sapiens_hsa05132	0.48416587
74	ABC transporters_Homo sapiens_hsa02010	0.47767686
75	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.46931505
76	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.45613874
77	Retinol metabolism_Homo sapiens_hsa00830	0.43877664
78	Metabolic pathways_Homo sapiens_hsa01100	0.43411537
79	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.41738259
80	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.40901474
81	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.40080520
82	Sulfur metabolism_Homo sapiens_hsa00920	0.38994801
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.38926860
84	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.37788299
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.36998393
86	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.33904933
87	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.33709346
88	One carbon pool by folate_Homo sapiens_hsa00670	0.32660890
89	GABAergic synapse_Homo sapiens_hsa04727	0.30613271
90	Taste transduction_Homo sapiens_hsa04742	0.29269004
91	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.28310894
92	beta-Alanine metabolism_Homo sapiens_hsa00410	0.27254808
93	Herpes simplex infection_Homo sapiens_hsa05168	0.25915032
94	Base excision repair_Homo sapiens_hsa03410	0.25653836
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.24822128
96	Sulfur relay system_Homo sapiens_hsa04122	0.24443842
97	Malaria_Homo sapiens_hsa05144	0.23510535
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.19869755
99	RNA transport_Homo sapiens_hsa03013	0.19613279
100	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.16568039

RPS26P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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