ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	signal peptide processing (GO:0006465)	6.70228070
2	ribosomal small subunit assembly (GO:0000028)	6.38710618
3	valine metabolic process (GO:0006573)	5.73551811
4	DNA deamination (GO:0045006)	5.67320452
5	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	5.62724133
6	mitochondrion transport along microtubule (GO:0047497)	5.62724133
7	establishment of mitochondrion localization (GO:0051654)	5.08387226
8	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	5.07695275
9	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.05913139
10	protein prenylation (GO:0018342)	4.60372171
11	prenylation (GO:0097354)	4.60372171
12	seminiferous tubule development (GO:0072520)	4.55392288
13	ribosomal small subunit biogenesis (GO:0042274)	4.45077896
14	cytidine deamination (GO:0009972)	4.42883639
15	cytidine metabolic process (GO:0046087)	4.42883639
16	cytidine catabolic process (GO:0006216)	4.42883639
17	L-methionine salvage (GO:0071267)	4.40822998
18	L-methionine biosynthetic process (GO:0071265)	4.40822998
19	amino acid salvage (GO:0043102)	4.40822998
20	viral transcription (GO:0019083)	4.35726775
21	branched-chain amino acid catabolic process (GO:0009083)	4.31285580
22	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.25215435
23	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.18476930
24	ATP synthesis coupled proton transport (GO:0015986)	4.18476930
25	translational termination (GO:0006415)	4.18407137
26	behavioral response to nicotine (GO:0035095)	4.16100600
27	cardiovascular system development (GO:0072358)	4.07534593
28	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.02113492
29	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.02113492
30	maturation of SSU-rRNA (GO:0030490)	4.01592121
31	macroautophagy (GO:0016236)	3.94785094
32	cellular response to interleukin-15 (GO:0071350)	3.92893359
33	GTP biosynthetic process (GO:0006183)	3.92642130
34	base-excision repair, AP site formation (GO:0006285)	3.89307207
35	adaptation of signaling pathway (GO:0023058)	3.78200831
36	translational elongation (GO:0006414)	3.77708268
37	protein targeting to ER (GO:0045047)	3.74439624
38	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.73449274
39	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.72631736
40	positive regulation of defense response to virus by host (GO:0002230)	3.68438490
41	cardiolipin metabolic process (GO:0032048)	3.67559031
42	phosphatidylglycerol biosynthetic process (GO:0006655)	3.66674180
43	cotranslational protein targeting to membrane (GO:0006613)	3.65071927
44	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.63845387
45	kynurenine metabolic process (GO:0070189)	3.55735876
46	protein localization to endoplasmic reticulum (GO:0070972)	3.52189645
47	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.50950250
48	tryptophan catabolic process (GO:0006569)	3.48383787
49	indole-containing compound catabolic process (GO:0042436)	3.48383787
50	indolalkylamine catabolic process (GO:0046218)	3.48383787
51	regulation of podosome assembly (GO:0071801)	3.45140924
52	indolalkylamine metabolic process (GO:0006586)	3.40127377
53	branched-chain amino acid metabolic process (GO:0009081)	3.35427575
54	fucose catabolic process (GO:0019317)	3.32842036
55	L-fucose metabolic process (GO:0042354)	3.32842036
56	L-fucose catabolic process (GO:0042355)	3.32842036
57	neuronal action potential propagation (GO:0019227)	3.31230549
58	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.30973575
59	ribosomal large subunit biogenesis (GO:0042273)	3.30854990
60	regulation of cGMP metabolic process (GO:0030823)	3.28133113
61	cytokinetic process (GO:0032506)	3.24313072
62	UTP biosynthetic process (GO:0006228)	3.18570089
63	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.18136654
64	cytochrome complex assembly (GO:0017004)	3.17524327
65	viral life cycle (GO:0019058)	3.05436686
66	cellular protein complex disassembly (GO:0043624)	3.04424735
67	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.02563039
68	multicellular organismal aging (GO:0010259)	2.99240789
69	protein complex biogenesis (GO:0070271)	2.97595850
70	regulation of isotype switching to IgG isotypes (GO:0048302)	2.96677305
71	respiratory chain complex IV assembly (GO:0008535)	2.96366273
72	tryptophan metabolic process (GO:0006568)	2.92475644
73	cellular response to nicotine (GO:0071316)	2.90453133
74	positive regulation of interleukin-8 secretion (GO:2000484)	2.89684224
75	detection of light stimulus involved in sensory perception (GO:0050962)	2.88765357
76	detection of light stimulus involved in visual perception (GO:0050908)	2.88765357
77	UTP metabolic process (GO:0046051)	2.88550629
78	respiratory electron transport chain (GO:0022904)	2.87897473
79	methionine biosynthetic process (GO:0009086)	2.84726198
80	electron transport chain (GO:0022900)	2.84647417
81	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.82755951
82	cellular ketone body metabolic process (GO:0046950)	2.79663135
83	response to interleukin-15 (GO:0070672)	2.78307521
84	regulation of translation in response to stress (GO:0043555)	2.78258534
85	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.77647060
86	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.74069497
87	protein neddylation (GO:0045116)	2.71278679
88	CTP metabolic process (GO:0046036)	2.70910666
89	CTP biosynthetic process (GO:0006241)	2.70910666
90	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.69938153
91	RNA destabilization (GO:0050779)	2.69724167
92	regulation of regulatory T cell differentiation (GO:0045589)	2.66197766
93	translational initiation (GO:0006413)	2.65809682
94	GPI anchor metabolic process (GO:0006505)	2.65475440
95	positive regulation of organelle assembly (GO:1902117)	2.65189751
96	mitochondrial respiratory chain complex assembly (GO:0033108)	2.65075542
97	chaperone-mediated protein transport (GO:0072321)	2.64217290
98	retina homeostasis (GO:0001895)	2.63803464
99	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.62923395
100	peptidyl-threonine dephosphorylation (GO:0035970)	2.61792163

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.19031017
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.51072402
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.53352326
4	VDR_22108803_ChIP-Seq_LS180_Human	3.41145857
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.15871335
6	EZH2_22144423_ChIP-Seq_EOC_Human	3.00047839
7	AR_21572438_ChIP-Seq_LNCaP_Human	2.89411990
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.79823181
9	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.68999608
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.52689525
11	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.42507735
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.39678444
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.19380519
14	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.14179981
15	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.98712743
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.90548669
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.88246800
18	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.72164211
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.71537136
20	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.67331778
21	RUNX_20019798_ChIP-Seq_JUKART_Human	1.64787775
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.63657020
23	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.62101234
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.60026034
25	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.57622766
26	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.51453386
27	VDR_23849224_ChIP-Seq_CD4+_Human	1.50930125
28	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.45341349
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.45014977
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.43874443
31	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.37894313
32	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.37190963
33	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.35866721
34	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.35385035
35	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.34890118
36	GBX2_23144817_ChIP-Seq_PC3_Human	1.34503538
37	BCL6_27268052_Chip-Seq_Bcells_Human	1.31919343
38	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.31092197
39	NANOG_20526341_ChIP-Seq_ESCs_Human	1.31063457
40	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.29581233
41	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.28063224
42	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27855479
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27855479
44	AR_20517297_ChIP-Seq_VCAP_Human	1.26545579
45	ER_23166858_ChIP-Seq_MCF-7_Human	1.26456314
46	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.24485234
47	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.24358712
48	ERA_21632823_ChIP-Seq_H3396_Human	1.24351692
49	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.23951741
50	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.22343736
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.22155185
52	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.21428063
53	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.20907356
54	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.19582670
55	TAF2_19829295_ChIP-Seq_ESCs_Human	1.18991172
56	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.18717523
57	SA1_27219007_Chip-Seq_Bcells_Human	1.18583972
58	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.18523653
59	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.18494006
60	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.17521276
61	IGF1R_20145208_ChIP-Seq_DFB_Human	1.16894003
62	MYC_18940864_ChIP-ChIP_HL60_Human	1.13833345
63	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.13679208
64	REST_21632747_ChIP-Seq_MESCs_Mouse	1.12999029
65	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.11620780
66	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.11230416
67	GATA3_26560356_Chip-Seq_TH2_Human	1.09151343
68	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.07191458
69	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.07039246
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06955041
71	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.06841971
72	SOX2_21211035_ChIP-Seq_LN229_Human	1.06366871
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06279637
74	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.05438783
75	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04919377
76	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.04047601
77	E2F1_20622854_ChIP-Seq_HELA_Human	1.03626087
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01800972
79	MYC_19829295_ChIP-Seq_ESCs_Human	1.00828686
80	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.00419212
81	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99591753
82	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.97939818
83	CTCF_20526341_ChIP-Seq_ESCs_Human	0.97710150
84	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.94379751
85	P300_27268052_Chip-Seq_Bcells_Human	0.93903270
86	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.93886153
87	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.93219529
88	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.91803836
89	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91667086
90	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91301966
91	NCOR_22424771_ChIP-Seq_293T_Human	0.90587173
92	NANOG_19829295_ChIP-Seq_ESCs_Human	0.90538196
93	SOX2_19829295_ChIP-Seq_ESCs_Human	0.90538196
94	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.90186485
95	MYB_26560356_Chip-Seq_TH2_Human	0.90113881
96	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.90030761
97	SMRT_27268052_Chip-Seq_Bcells_Human	0.88584644
98	EWS_26573619_Chip-Seq_HEK293_Human	0.87830705
99	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.87623416
100	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.87558342

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	7.78842665
2	MP0003646_muscle_fatigue	4.10179014
3	MP0005671_abnormal_response_to	3.56703194
4	MP0004145_abnormal_muscle_electrophysio	2.69711389
5	MP0001873_stomach_inflammation	2.62274310
6	MP0005397_hematopoietic_system_phenotyp	2.52097152
7	MP0001545_abnormal_hematopoietic_system	2.52097152
8	MP0008872_abnormal_physiological_respon	2.46016965
9	MP0008877_abnormal_DNA_methylation	2.36155939
10	MP0004885_abnormal_endolymph	2.12915405
11	MP0002638_abnormal_pupillary_reflex	2.11256317
12	MP0005360_urolithiasis	2.09496368
13	MP0000372_irregular_coat_pigmentation	2.02794916
14	MP0005551_abnormal_eye_electrophysiolog	1.88454339
15	MP0002163_abnormal_gland_morphology	1.81885843
16	MP0001835_abnormal_antigen_presentation	1.78575018
17	MP0005645_abnormal_hypothalamus_physiol	1.77998984
18	MP0001348_abnormal_lacrimal_gland	1.77605503
19	MP0001800_abnormal_humoral_immune	1.64636800
20	MP0008875_abnormal_xenobiotic_pharmacok	1.60703393
21	MP0006072_abnormal_retinal_apoptosis	1.53941291
22	MP0008058_abnormal_DNA_repair	1.51693733
23	MP0001790_abnormal_immune_system	1.50428775
24	MP0005387_immune_system_phenotype	1.50428775
25	MP0003011_delayed_dark_adaptation	1.47413761
26	MP0002736_abnormal_nociception_after	1.47303391
27	MP0009785_altered_susceptibility_to	1.45004410
28	MP0001968_abnormal_touch/_nociception	1.43192076
29	MP0006276_abnormal_autonomic_nervous	1.40850176
30	MP0001663_abnormal_digestive_system	1.38869722
31	MP0001919_abnormal_reproductive_system	1.37072770
32	MP0005085_abnormal_gallbladder_physiolo	1.35105464
33	MP0006292_abnormal_olfactory_placode	1.33864227
34	MP0003787_abnormal_imprinting	1.33629659
35	MP0004742_abnormal_vestibular_system	1.33311914
36	MP0004858_abnormal_nervous_system	1.30484272
37	MP0002723_abnormal_immune_serum	1.26132660
38	MP0005000_abnormal_immune_tolerance	1.24829612
39	MP0002148_abnormal_hypersensitivity_rea	1.21282719
40	MP0005389_reproductive_system_phenotype	1.17978419
41	MP0001905_abnormal_dopamine_level	1.14993074
42	MP0002272_abnormal_nervous_system	1.12386928
43	MP0004043_abnormal_pH_regulation	1.11972193
44	MP0002420_abnormal_adaptive_immunity	1.11825858
45	MP0004142_abnormal_muscle_tone	1.09194231
46	MP0003136_yellow_coat_color	1.08532851
47	MP0001819_abnormal_immune_cell	1.08281267
48	MP0006036_abnormal_mitochondrial_physio	1.07698974
49	MP0009046_muscle_twitch	1.07160047
50	MP0001501_abnormal_sleep_pattern	1.05780196
51	MP0000685_abnormal_immune_system	1.05773913
52	MP0002452_abnormal_antigen_presenting	1.05201333
53	MP0003866_abnormal_defecation	1.04064262
54	MP0009333_abnormal_splenocyte_physiolog	1.03413058
55	MP0003724_increased_susceptibility_to	0.99893905
56	MP0001845_abnormal_inflammatory_respons	0.98963427
57	MP0003195_calcinosis	0.98921388
58	MP0002933_joint_inflammation	0.98770073
59	MP0005410_abnormal_fertilization	0.98604458
60	MP0005365_abnormal_bile_salt	0.98520238
61	MP0008789_abnormal_olfactory_epithelium	0.98506553
62	MP0005025_abnormal_response_to	0.97548093
63	MP0003186_abnormal_redox_activity	0.96550500
64	MP0003786_premature_aging	0.95314404
65	MP0001765_abnormal_ion_homeostasis	0.92890628
66	MP0008569_lethality_at_weaning	0.92712491
67	MP0003436_decreased_susceptibility_to	0.92156591
68	MP0008775_abnormal_heart_ventricle	0.91177154
69	MP0010155_abnormal_intestine_physiology	0.90665321
70	MP0002102_abnormal_ear_morphology	0.89966330
71	MP0001485_abnormal_pinna_reflex	0.89384680
72	MP0005646_abnormal_pituitary_gland	0.88833863
73	MP0009745_abnormal_behavioral_response	0.87366117
74	MP0005379_endocrine/exocrine_gland_phen	0.86677795
75	MP0002557_abnormal_social/conspecific_i	0.86074575
76	MP0005253_abnormal_eye_physiology	0.85095321
77	MP0008995_early_reproductive_senescence	0.83676459
78	MP0000230_abnormal_systemic_arterial	0.83255192
79	MP0001986_abnormal_taste_sensitivity	0.82242982
80	MP0002095_abnormal_skin_pigmentation	0.81361565
81	MP0002733_abnormal_thermal_nociception	0.81262502
82	MP0005636_abnormal_mineral_homeostasis	0.81118163
83	MP0005381_digestive/alimentary_phenotyp	0.80786422
84	MP0000716_abnormal_immune_system	0.80402273
85	MP0003718_maternal_effect	0.78084701
86	MP0001970_abnormal_pain_threshold	0.76914039
87	MP0002405_respiratory_system_inflammati	0.74090241
88	MP0002837_dystrophic_cardiac_calcinosis	0.73157286
89	MP0005195_abnormal_posterior_eye	0.71319244
90	MP0002234_abnormal_pharynx_morphology	0.71206212
91	MP0002229_neurodegeneration	0.67950274
92	MP0003879_abnormal_hair_cell	0.67784428
93	MP0003693_abnormal_embryo_hatching	0.66993019
94	MP0010329_abnormal_lipoprotein_level	0.66101978
95	MP0003635_abnormal_synaptic_transmissio	0.65809585
96	MP0005174_abnormal_tail_pigmentation	0.65265641
97	MP0000631_abnormal_neuroendocrine_gland	0.63379724
98	MP0002160_abnormal_reproductive_system	0.62713802
99	MP0004782_abnormal_surfactant_physiolog	0.62346105
100	MP0002735_abnormal_chemical_nociception	0.62258067

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	7.85851744
2	Pendular nystagmus (HP:0012043)	5.90856809
3	Abnormal rod and cone electroretinograms (HP:0008323)	5.54062497
4	Decreased central vision (HP:0007663)	5.40117141
5	Acanthocytosis (HP:0001927)	5.06667280
6	Keratoconus (HP:0000563)	4.39611901
7	Increased corneal curvature (HP:0100692)	4.39611901
8	Attenuation of retinal blood vessels (HP:0007843)	4.31765683
9	Self-mutilation (HP:0000742)	3.78177067
10	Agitation (HP:0000713)	3.72058966
11	Disinhibition (HP:0000734)	3.63690897
12	Cerebral hypomyelination (HP:0006808)	3.38589858
13	Congenital stationary night blindness (HP:0007642)	3.37640333
14	Personality changes (HP:0000751)	3.16510385
15	Carpal bone hypoplasia (HP:0001498)	3.16393918
16	Dyskinesia (HP:0100660)	3.10341557
17	Acute necrotizing encephalopathy (HP:0006965)	3.08575400
18	Stomach cancer (HP:0012126)	2.96479547
19	Reticulocytopenia (HP:0001896)	2.93698812
20	Pallor (HP:0000980)	2.76076590
21	Optic disc pallor (HP:0000543)	2.75579416
22	Increased hepatocellular lipid droplets (HP:0006565)	2.75563574
23	Abnormal mitochondria in muscle tissue (HP:0008316)	2.72084796
24	Acute hepatic failure (HP:0006554)	2.71864821
25	Inappropriate behavior (HP:0000719)	2.71167137
26	Mitochondrial inheritance (HP:0001427)	2.68009461
27	IgG deficiency (HP:0004315)	2.59630712
28	Abolished electroretinogram (ERG) (HP:0000550)	2.57045686
29	Delayed CNS myelination (HP:0002188)	2.55504583
30	Lipid accumulation in hepatocytes (HP:0006561)	2.52767019
31	Acute encephalopathy (HP:0006846)	2.47287912
32	Increased CSF lactate (HP:0002490)	2.45734302
33	Abnormality of T cell number (HP:0011839)	2.44098252
34	Progressive macrocephaly (HP:0004481)	2.42517190
35	Psychosis (HP:0000709)	2.41817929
36	Macular degeneration (HP:0000608)	2.40633644
37	CNS hypomyelination (HP:0003429)	2.39539430
38	Elevated erythrocyte sedimentation rate (HP:0003565)	2.37358597
39	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.34822694
40	Asplenia (HP:0001746)	2.33045650
41	Drooling (HP:0002307)	2.32734159
42	Irregular epiphyses (HP:0010582)	2.29045413
43	Gaze-evoked nystagmus (HP:0000640)	2.21664997
44	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.20113922
45	Oligomenorrhea (HP:0000876)	2.19183193
46	Abnormality of cells of the erythroid lineage (HP:0012130)	2.18611586
47	Excessive salivation (HP:0003781)	2.18330951
48	Vasculitis (HP:0002633)	2.17595776
49	Abnormality of fatty-acid metabolism (HP:0004359)	2.15385368
50	Optic neuritis (HP:0100653)	2.14613343
51	Retrobulbar optic neuritis (HP:0100654)	2.14613343
52	Renal cortical cysts (HP:0000803)	2.14342959
53	Poikilocytosis (HP:0004447)	2.13920532
54	Abnormality of the renal cortex (HP:0011035)	2.11932131
55	Hepatocellular necrosis (HP:0001404)	2.11710162
56	Abnormal number of erythroid precursors (HP:0012131)	2.09051193
57	Constricted visual fields (HP:0001133)	2.06826714
58	Synostosis of carpal bones (HP:0005048)	2.04705061
59	T lymphocytopenia (HP:0005403)	2.04392681
60	Renal Fanconi syndrome (HP:0001994)	2.03111375
61	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.02077769
62	Anxiety (HP:0000739)	2.00414118
63	Hypoplasia of the uterus (HP:0000013)	1.99886782
64	Pancreatic cysts (HP:0001737)	1.95539335
65	CNS demyelination (HP:0007305)	1.92422798
66	Pancreatic fibrosis (HP:0100732)	1.91275652
67	Delusions (HP:0000746)	1.89050710
68	True hermaphroditism (HP:0010459)	1.88391754
69	Increased intramyocellular lipid droplets (HP:0012240)	1.88142706
70	Unsteady gait (HP:0002317)	1.88022951
71	Aplasia/hypoplasia of the uterus (HP:0008684)	1.87880853
72	Medial flaring of the eyebrow (HP:0010747)	1.87123929
73	Choreoathetosis (HP:0001266)	1.85822588
74	Anencephaly (HP:0002323)	1.85527138
75	Myositis (HP:0100614)	1.85098757
76	Alkalosis (HP:0001948)	1.84819716
77	Colon cancer (HP:0003003)	1.84677500
78	Premature ovarian failure (HP:0008209)	1.84633207
79	Exertional dyspnea (HP:0002875)	1.81312708
80	Abnormality of the costochondral junction (HP:0000919)	1.79652774
81	Cerebral palsy (HP:0100021)	1.76615397
82	3-Methylglutaconic aciduria (HP:0003535)	1.75581648
83	Abnormality of T cells (HP:0002843)	1.74123351
84	Emotional lability (HP:0000712)	1.74105264
85	Cerebral edema (HP:0002181)	1.73726046
86	Hepatic necrosis (HP:0002605)	1.72991685
87	Restlessness (HP:0000711)	1.72849501
88	Abnormality of DNA repair (HP:0003254)	1.72784595
89	Hypochromic anemia (HP:0001931)	1.72341150
90	Abnormality of alanine metabolism (HP:0010916)	1.71808906
91	Hyperalaninemia (HP:0003348)	1.71808906
92	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.71808906
93	Parakeratosis (HP:0001036)	1.71279070
94	Hyperphosphaturia (HP:0003109)	1.70603822
95	Oral leukoplakia (HP:0002745)	1.67741728
96	Increased serum lactate (HP:0002151)	1.67044306
97	Postaxial foot polydactyly (HP:0001830)	1.66996880
98	Infantile muscular hypotonia (HP:0008947)	1.66977424
99	Orchitis (HP:0100796)	1.66647198
100	Abnormality of eosinophils (HP:0001879)	1.64004996

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	5.33833007
2	MAP4K1	3.32740304
3	TXK	3.17941310
4	PINK1	3.04977024
5	ZAK	2.94046999
6	TLK1	2.87487958
7	ADRBK2	2.37655425
8	GRK6	2.35138162
9	NME1	2.23910819
10	WNK4	2.20837834
11	TAOK3	2.18663694
12	BMPR2	2.15233105
13	WNK3	2.08046905
14	KDR	2.06237426
15	RIPK4	2.04838829
16	GRK1	1.95066742
17	VRK2	1.94431192
18	PASK	1.79284374
19	BCKDK	1.70915890
20	ITK	1.68123586
21	CAMKK1	1.65206201
22	MAP2K6	1.45510830
23	NUAK1	1.42797921
24	CAMKK2	1.37262687
25	MAP3K11	1.30217532
26	VRK1	1.23244218
27	MUSK	1.20315090
28	PRKCQ	1.18516119
29	MAP3K4	1.18274886
30	FRK	1.16972699
31	PLK2	1.13539785
32	TNK2	1.11183078
33	INSRR	1.03275137
34	KIT	1.00420972
35	MST4	0.99953809
36	LRRK2	0.98917214
37	SYK	0.95608396
38	BMPR1B	0.92448811
39	PDK2	0.90801308
40	IKBKB	0.88095567
41	TIE1	0.87643596
42	PRKCG	0.86158126
43	MAPKAPK5	0.84672464
44	MAP4K2	0.84371653
45	ADRBK1	0.81027300
46	MATK	0.80023149
47	PRKACA	0.79646022
48	PIM1	0.78227951
49	CAMK1	0.77142049
50	PLK4	0.75006153
51	PKN1	0.72497112
52	GRK7	0.70612945
53	AURKA	0.70505875
54	LCK	0.68279122
55	TEC	0.65166234
56	OBSCN	0.64887415
57	FLT3	0.62045507
58	MAP3K12	0.60830218
59	RPS6KA5	0.60237246
60	PRKCA	0.59243101
61	PNCK	0.55781216
62	PHKG1	0.55025261
63	PHKG2	0.55025261
64	CAMK2A	0.54911836
65	MYLK	0.54615588
66	MAPK13	0.54588004
67	ERBB2	0.54576016
68	OXSR1	0.53703755
69	STK39	0.53221700
70	PRKCH	0.52959110
71	FES	0.50421201
72	CSNK2A1	0.48990758
73	PRKCI	0.48227135
74	PIK3CA	0.47932116
75	RPS6KA6	0.46331356
76	DYRK2	0.45851627
77	EPHB2	0.45289891
78	PRKACG	0.44628842
79	TESK2	0.43183178
80	CSNK1D	0.42449102
81	IGF1R	0.41665858
82	ERBB3	0.40720286
83	CSNK2A2	0.40588917
84	BTK	0.40341834
85	MKNK2	0.39846265
86	MAPK15	0.39422758
87	GRK5	0.38719205
88	CSNK1G3	0.38308447
89	ABL2	0.36855685
90	ROCK1	0.36415876
91	PIM2	0.35532965
92	CSF1R	0.35057645
93	MAP2K2	0.34441780
94	PLK3	0.34347945
95	STK10	0.33894467
96	NTRK2	0.32464153
97	CSK	0.32329714
98	PRKCB	0.31551189
99	RPS6KA3	0.30601387
100	MAP2K1	0.29855110

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.02550268
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.14011443
3	Primary immunodeficiency_Homo sapiens_hsa05340	3.05299369
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.95769590
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.66768956
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.39697178
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.37297352
8	Parkinsons disease_Homo sapiens_hsa05012	2.35936392
9	Allograft rejection_Homo sapiens_hsa05330	2.31795147
10	Asthma_Homo sapiens_hsa05310	2.15940550
11	Proteasome_Homo sapiens_hsa03050	2.12544604
12	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.08186485
13	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.07807796
14	RNA polymerase_Homo sapiens_hsa03020	2.01353340
15	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.95687927
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.87866914
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.87285499
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.86883740
19	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.72260115
20	Alzheimers disease_Homo sapiens_hsa05010	1.65119604
21	Protein export_Homo sapiens_hsa03060	1.57983100
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.56650020
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.51279629
24	Huntingtons disease_Homo sapiens_hsa05016	1.48568092
25	Type I diabetes mellitus_Homo sapiens_hsa04940	1.44978409
26	Homologous recombination_Homo sapiens_hsa03440	1.38061823
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.36628155
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.36007982
29	RNA degradation_Homo sapiens_hsa03018	1.35766098
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.24834501
31	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.22799170
32	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.19350007
33	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.16759210
34	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.15928691
35	Olfactory transduction_Homo sapiens_hsa04740	1.15606022
36	Antigen processing and presentation_Homo sapiens_hsa04612	1.15416137
37	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.15290055
38	Linoleic acid metabolism_Homo sapiens_hsa00591	1.14692038
39	Peroxisome_Homo sapiens_hsa04146	1.13930238
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.12873200
41	Phototransduction_Homo sapiens_hsa04744	1.10099900
42	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.05995318
43	Sulfur relay system_Homo sapiens_hsa04122	1.02625496
44	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.98627718
45	Pyrimidine metabolism_Homo sapiens_hsa00240	0.97131923
46	Caffeine metabolism_Homo sapiens_hsa00232	0.95484277
47	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.93478995
48	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.92693426
49	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.90633497
50	Retinol metabolism_Homo sapiens_hsa00830	0.89665126
51	Nicotine addiction_Homo sapiens_hsa05033	0.89491958
52	Salivary secretion_Homo sapiens_hsa04970	0.88358605
53	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.82564948
54	Morphine addiction_Homo sapiens_hsa05032	0.82320399
55	Propanoate metabolism_Homo sapiens_hsa00640	0.82314421
56	Rheumatoid arthritis_Homo sapiens_hsa05323	0.77714831
57	ABC transporters_Homo sapiens_hsa02010	0.75453262
58	Non-homologous end-joining_Homo sapiens_hsa03450	0.74382590
59	Butanoate metabolism_Homo sapiens_hsa00650	0.73570232
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73471001
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.71043518
62	Selenocompound metabolism_Homo sapiens_hsa00450	0.66480269
63	Purine metabolism_Homo sapiens_hsa00230	0.66330023
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62732479
65	African trypanosomiasis_Homo sapiens_hsa05143	0.62621938
66	Pyruvate metabolism_Homo sapiens_hsa00620	0.60431822
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59965957
68	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.59639394
69	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.59423835
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59359247
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.57746477
72	Basal transcription factors_Homo sapiens_hsa03022	0.57433034
73	Metabolic pathways_Homo sapiens_hsa01100	0.56937656
74	Taste transduction_Homo sapiens_hsa04742	0.56680347
75	Insulin secretion_Homo sapiens_hsa04911	0.55956883
76	Circadian entrainment_Homo sapiens_hsa04713	0.52210480
77	One carbon pool by folate_Homo sapiens_hsa00670	0.50939817
78	Steroid biosynthesis_Homo sapiens_hsa00100	0.49671422
79	Pancreatic secretion_Homo sapiens_hsa04972	0.48575433
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.48158993
81	Base excision repair_Homo sapiens_hsa03410	0.46901257
82	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.46833988
83	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.43521983
84	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.40282781
85	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.40164854
86	Tyrosine metabolism_Homo sapiens_hsa00350	0.39448575
87	GABAergic synapse_Homo sapiens_hsa04727	0.38391141
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.37550397
89	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.37463106
90	Mismatch repair_Homo sapiens_hsa03430	0.37183188
91	Fanconi anemia pathway_Homo sapiens_hsa03460	0.36433683
92	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.36028505
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.35958876
94	Serotonergic synapse_Homo sapiens_hsa04726	0.34270492
95	Viral myocarditis_Homo sapiens_hsa05416	0.34153888
96	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.32088573
97	Mineral absorption_Homo sapiens_hsa04978	0.32061499
98	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.29524078
99	Collecting duct acid secretion_Homo sapiens_hsa04966	0.29136685
100	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.27711553

RPS26P13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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