ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cytidine metabolic process (GO:0046087)	9.15479544
2	cytidine catabolic process (GO:0006216)	9.15479544
3	cytidine deamination (GO:0009972)	9.15479544
4	DNA deamination (GO:0045006)	8.29063884
5	pyrimidine ribonucleoside catabolic process (GO:0046133)	8.08953392
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	8.03346635
7	Arp2/3 complex-mediated actin nucleation (GO:0034314)	4.85470464
8	positive thymic T cell selection (GO:0045059)	4.56240961
9	ribosomal small subunit assembly (GO:0000028)	4.51267339
10	positive T cell selection (GO:0043368)	4.46106181
11	negative regulation by host of viral transcription (GO:0043922)	4.46055298
12	actin nucleation (GO:0045010)	4.42294205
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.35796702
14	regulation of activation of Janus kinase activity (GO:0010533)	4.31440674
15	positive regulation of interleukin-8 secretion (GO:2000484)	4.29311354
16	T cell migration (GO:0072678)	4.27451416
17	pyrimidine nucleoside catabolic process (GO:0046135)	4.24955808
18	sequestering of actin monomers (GO:0042989)	4.22184443
19	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	4.21981206
20	positive regulation of calcium-mediated signaling (GO:0050850)	4.20037193
21	positive regulation of natural killer cell mediated immunity (GO:0002717)	4.17108292
22	negative T cell selection (GO:0043383)	4.12784059
23	negative regulation of T cell apoptotic process (GO:0070233)	4.11550813
24	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.06192713
25	ATP synthesis coupled proton transport (GO:0015986)	4.06192713
26	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.02973935
27	negative regulation of viral genome replication (GO:0045071)	3.95565325
28	positive regulation of B cell differentiation (GO:0045579)	3.93864024
29	eosinophil chemotaxis (GO:0048245)	3.87743794
30	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.83769755
31	regulation of regulatory T cell differentiation (GO:0045589)	3.80591664
32	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.70370051
33	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.69047554
34	regulation of B cell receptor signaling pathway (GO:0050855)	3.65744691
35	cytolysis (GO:0019835)	3.64785524
36	regulation of natural killer cell mediated immunity (GO:0002715)	3.64159505
37	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	3.64159505
38	cellular response to interleukin-15 (GO:0071350)	3.60529171
39	macrophage chemotaxis (GO:0048246)	3.59990264
40	respiratory electron transport chain (GO:0022904)	3.57813597
41	eosinophil migration (GO:0072677)	3.52267530
42	protein neddylation (GO:0045116)	3.51884317
43	electron transport chain (GO:0022900)	3.50902333
44	thymic T cell selection (GO:0045061)	3.49407432
45	regulation of leukocyte mediated cytotoxicity (GO:0001910)	3.48086680
46	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.46967272
47	positive regulation of cell killing (GO:0031343)	3.46598363
48	response to interferon-beta (GO:0035456)	3.42169811
49	regulation of interleukin-8 secretion (GO:2000482)	3.36455859
50	positive regulation of T cell apoptotic process (GO:0070234)	3.36325017
51	negative regulation of lymphocyte apoptotic process (GO:0070229)	3.31030055
52	positive regulation of tolerance induction (GO:0002645)	3.30944218
53	negative thymic T cell selection (GO:0045060)	3.30079809
54	positive regulation of alpha-beta T cell proliferation (GO:0046641)	3.25729812
55	positive regulation of gamma-delta T cell activation (GO:0046645)	3.25238860
56	regulation of T cell mediated cytotoxicity (GO:0001914)	3.20434923
57	regulation of B cell differentiation (GO:0045577)	3.19642897
58	regulation of T cell tolerance induction (GO:0002664)	3.17477844
59	regulation of chronic inflammatory response (GO:0002676)	3.17051720
60	regulation of cell killing (GO:0031341)	3.16917722
61	regulation of T cell receptor signaling pathway (GO:0050856)	3.14001949
62	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.13771624
63	T cell receptor signaling pathway (GO:0050852)	3.12515187
64	DNA demethylation (GO:0080111)	3.10884522
65	positive regulation of monocyte chemotaxis (GO:0090026)	3.09322476
66	regulation of lymphocyte chemotaxis (GO:1901623)	3.07050425
67	regulation of T cell chemotaxis (GO:0010819)	3.06708372
68	positive regulation of T cell chemotaxis (GO:0010820)	3.06708372
69	DNA dealkylation (GO:0035510)	3.05522330
70	metallo-sulfur cluster assembly (GO:0031163)	3.05008753
71	iron-sulfur cluster assembly (GO:0016226)	3.05008753
72	T cell selection (GO:0045058)	3.03279300
73	regulation of calcium-mediated signaling (GO:0050848)	3.02641875
74	pyrimidine-containing compound catabolic process (GO:0072529)	3.00324300
75	positive regulation of defense response to virus by host (GO:0002230)	2.98610877
76	T cell costimulation (GO:0031295)	2.98065043
77	positive regulation of lymphocyte migration (GO:2000403)	2.97628176
78	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.97110749
79	regulation of T cell apoptotic process (GO:0070232)	2.97098335
80	regulation of alpha-beta T cell proliferation (GO:0046640)	2.95986676
81	lymphocyte costimulation (GO:0031294)	2.94523749
82	regulation of cellular amino acid metabolic process (GO:0006521)	2.94021502
83	protein complex biogenesis (GO:0070271)	2.93614837
84	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.91629745
85	proteasome assembly (GO:0043248)	2.90738499
86	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.88825914
87	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.83936811
88	maturation of SSU-rRNA (GO:0030490)	2.81673288
89	regulation of viral genome replication (GO:0045069)	2.81517609
90	response to interleukin-15 (GO:0070672)	2.80958048
91	regulation of gamma-delta T cell differentiation (GO:0045586)	2.80688385
92	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.76641364
93	negative regulation of mast cell activation (GO:0033004)	2.74263230
94	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.74063594
95	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.72747622
96	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.72747622
97	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.72260671
98	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.71227388
99	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.71227388
100	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.71227388

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.97243540
2	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.02737631
3	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.87090084
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.36339007
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.28843142
6	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.27022820
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.18198651
8	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.06973236
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.78008238
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.74198869
11	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.65875736
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.64504608
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.55279036
14	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.35325166
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.26160347
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.17309631
17	MYB_26560356_Chip-Seq_TH2_Human	2.13011830
18	VDR_22108803_ChIP-Seq_LS180_Human	2.11668051
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.10102845
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.08084488
21	EZH2_22144423_ChIP-Seq_EOC_Human	2.01200263
22	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.88316228
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.87836885
24	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.85697653
25	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.79972883
26	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.77482153
27	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.74904973
28	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.70739094
29	GATA3_27048872_Chip-Seq_THYMUS_Human	1.68497509
30	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.68275460
31	RUNX_20019798_ChIP-Seq_JUKART_Human	1.67270495
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.58418168
33	FOXP3_21729870_ChIP-Seq_TREG_Human	1.56120296
34	ZNF274_21170338_ChIP-Seq_K562_Hela	1.53447156
35	GATA3_26560356_Chip-Seq_TH2_Human	1.53187437
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.50773763
37	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.49080684
38	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.48721361
39	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.46044835
40	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.44877896
41	UTX_26944678_Chip-Seq_JUKART_Human	1.38448575
42	MYB_26560356_Chip-Seq_TH1_Human	1.37374429
43	IGF1R_20145208_ChIP-Seq_DFB_Human	1.36547039
44	NANOG_20526341_ChIP-Seq_ESCs_Human	1.35584220
45	BCL6_27268052_Chip-Seq_Bcells_Human	1.33961632
46	HTT_18923047_ChIP-ChIP_STHdh_Human	1.28689503
47	MYC_18940864_ChIP-ChIP_HL60_Human	1.27523646
48	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.25118649
49	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.25077046
50	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.21764094
51	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.20024553
52	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.19733807
53	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.19474870
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.18772210
55	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.17993387
56	AR_20517297_ChIP-Seq_VCAP_Human	1.17127910
57	TAF2_19829295_ChIP-Seq_ESCs_Human	1.16981714
58	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.15233006
59	MAF_26560356_Chip-Seq_TH2_Human	1.14406402
60	ELK1_19687146_ChIP-ChIP_HELA_Human	1.13809164
61	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13080103
62	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.12175516
63	NCOR_22424771_ChIP-Seq_293T_Human	1.11478809
64	CIITA_25753668_ChIP-Seq_RAJI_Human	1.07357177
65	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06992043
66	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.06507868
67	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.06415562
68	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.03200270
69	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02746606
70	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.02708906
71	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.02599946
72	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.02410582
73	MAF_26560356_Chip-Seq_TH1_Human	1.01402281
74	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.00611131
75	P300_27268052_Chip-Seq_Bcells_Human	0.99979821
76	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.99650938
77	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.99508876
78	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99486475
79	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99486475
80	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99119583
81	CTCF_20526341_ChIP-Seq_ESCs_Human	0.98382930
82	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.97542587
83	MYC_19829295_ChIP-Seq_ESCs_Human	0.97486208
84	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	0.97063477
85	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.96052855
86	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.95989942
87	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.95179897
88	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.95081004
89	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.94670850
90	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.94007584
91	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.94007584
92	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.93160915
93	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.92519659
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.91578116
95	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.91323712
96	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.91052249
97	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.90659570
98	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.90624554
99	ERG_20517297_ChIP-Seq_VCAP_Human	0.90478030
100	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.90226012

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	6.27965633
2	MP0009785_altered_susceptibility_to	3.28652385
3	MP0003763_abnormal_thymus_physiology	2.93140214
4	MP0001835_abnormal_antigen_presentation	2.79529926
5	MP0005645_abnormal_hypothalamus_physiol	2.72492074
6	MP0009379_abnormal_foot_pigmentation	2.68032444
7	MP0009333_abnormal_splenocyte_physiolog	2.62247206
8	MP0005000_abnormal_immune_tolerance	2.45246165
9	MP0001800_abnormal_humoral_immune	2.30080944
10	MP0005025_abnormal_response_to	2.28744486
11	MP0002148_abnormal_hypersensitivity_rea	2.23491247
12	MP0000685_abnormal_immune_system	2.18026636
13	MP0002420_abnormal_adaptive_immunity	2.17006029
14	MP0006082_CNS_inflammation	2.12822977
15	MP0002723_abnormal_immune_serum	2.12068432
16	MP0001819_abnormal_immune_cell	2.08819431
17	MP0003866_abnormal_defecation	2.02027885
18	MP0001873_stomach_inflammation	1.98150540
19	MP0001790_abnormal_immune_system	1.97601025
20	MP0005387_immune_system_phenotype	1.97601025
21	MP0000372_irregular_coat_pigmentation	1.89977917
22	MP0008872_abnormal_physiological_respon	1.82516256
23	MP0004145_abnormal_muscle_electrophysio	1.78349858
24	MP0000716_abnormal_immune_system	1.72160935
25	MP0002452_abnormal_antigen_presenting	1.70666426
26	MP0002398_abnormal_bone_marrow	1.68449617
27	MP0010155_abnormal_intestine_physiology	1.67648482
28	MP0003646_muscle_fatigue	1.66008449
29	MP0002166_altered_tumor_susceptibility	1.61884182
30	MP0001919_abnormal_reproductive_system	1.56823893
31	MP0000703_abnormal_thymus_morphology	1.45888756
32	MP0002138_abnormal_hepatobiliary_system	1.43101473
33	MP0002405_respiratory_system_inflammati	1.39218547
34	MP0001845_abnormal_inflammatory_respons	1.38291653
35	MP0001905_abnormal_dopamine_level	1.37255282
36	MP0004147_increased_porphyrin_level	1.35754361
37	MP0002722_abnormal_immune_system	1.34721085
38	MP0003786_premature_aging	1.34538441
39	MP0003011_delayed_dark_adaptation	1.34366375
40	MP0002163_abnormal_gland_morphology	1.34071396
41	MP0005646_abnormal_pituitary_gland	1.31505428
42	MP0005389_reproductive_system_phenotype	1.31500785
43	MP0002102_abnormal_ear_morphology	1.31198199
44	MP0001968_abnormal_touch/_nociception	1.30522515
45	MP0002277_abnormal_respiratory_mucosa	1.30237483
46	MP0002429_abnormal_blood_cell	1.30228310
47	MP0002736_abnormal_nociception_after	1.29637549
48	MP0000689_abnormal_spleen_morphology	1.28882859
49	MP0002006_tumorigenesis	1.28280020
50	MP0002933_joint_inflammation	1.25946097
51	MP0002419_abnormal_innate_immunity	1.22360648
52	MP0005377_hearing/vestibular/ear_phenot	1.19731251
53	MP0003878_abnormal_ear_physiology	1.19731251
54	MP0005551_abnormal_eye_electrophysiolog	1.17977634
55	MP0003045_fibrosis	1.13064347
56	MP0006072_abnormal_retinal_apoptosis	1.07935668
57	MP0008875_abnormal_xenobiotic_pharmacok	1.07737560
58	MP0001853_heart_inflammation	1.06512967
59	MP0002638_abnormal_pupillary_reflex	1.05670502
60	MP0008469_abnormal_protein_level	1.05505358
61	MP0003448_altered_tumor_morphology	1.05145634
62	MP0010386_abnormal_urinary_bladder	1.04824826
63	MP0001485_abnormal_pinna_reflex	1.04582007
64	MP0005075_abnormal_melanosome_morpholog	1.03757397
65	MP0001764_abnormal_homeostasis	1.02647939
66	MP0005084_abnormal_gallbladder_morpholo	1.00992116
67	MP0008995_early_reproductive_senescence	1.00143030
68	MP0009763_increased_sensitivity_to	0.99876479
69	MP0005464_abnormal_platelet_physiology	0.98069782
70	MP0003806_abnormal_nucleotide_metabolis	0.97550559
71	MP0002837_dystrophic_cardiac_calcinosis	0.97297666
72	MP0006036_abnormal_mitochondrial_physio	0.96251573
73	MP0002876_abnormal_thyroid_physiology	0.95690167
74	MP0003436_decreased_susceptibility_to	0.94828512
75	MP0005636_abnormal_mineral_homeostasis	0.92204560
76	MP0002095_abnormal_skin_pigmentation	0.91992323
77	MP0002693_abnormal_pancreas_physiology	0.90701358
78	MP0005410_abnormal_fertilization	0.90357092
79	MP0003880_abnormal_central_pattern	0.89350511
80	MP0002019_abnormal_tumor_incidence	0.85190281
81	MP0008877_abnormal_DNA_methylation	0.83023272
82	MP0006276_abnormal_autonomic_nervous	0.81366928
83	MP0002733_abnormal_thermal_nociception	0.80204231
84	MP0009745_abnormal_behavioral_response	0.79862366
85	MP0003137_abnormal_impulse_conducting	0.79358984
86	MP0005379_endocrine/exocrine_gland_phen	0.79164578
87	MP0005253_abnormal_eye_physiology	0.78466678
88	MP0001765_abnormal_ion_homeostasis	0.78045616
89	MP0005166_decreased_susceptibility_to	0.77671752
90	MP0004742_abnormal_vestibular_system	0.77665027
91	MP0002160_abnormal_reproductive_system	0.77001286
92	MP0009643_abnormal_urine_homeostasis	0.76759581
93	MP0009765_abnormal_xenobiotic_induced	0.76395105
94	MP0003195_calcinosis	0.74575507
95	MP0006292_abnormal_olfactory_placode	0.74574572
96	MP0009764_decreased_sensitivity_to	0.74403992
97	MP0001986_abnormal_taste_sensitivity	0.73151052
98	MP0001542_abnormal_bone_strength	0.72669613
99	MP0000631_abnormal_neuroendocrine_gland	0.70657269
100	MP0001970_abnormal_pain_threshold	0.69728738

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	5.89373162
2	T lymphocytopenia (HP:0005403)	5.01777067
3	Abnormality of T cell number (HP:0011839)	4.91377993
4	IgG deficiency (HP:0004315)	4.27425734
5	Hypoproteinemia (HP:0003075)	4.16888667
6	Mitochondrial inheritance (HP:0001427)	3.94538271
7	Severe combined immunodeficiency (HP:0004430)	3.91510776
8	Autoimmune hemolytic anemia (HP:0001890)	3.77867414
9	Acute necrotizing encephalopathy (HP:0006965)	3.76438390
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.62897864
11	3-Methylglutaconic aciduria (HP:0003535)	3.59387324
12	Abnormality of T cells (HP:0002843)	3.46321600
13	Increased intramyocellular lipid droplets (HP:0012240)	3.44394967
14	Increased IgM level (HP:0003496)	3.42280158
15	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.39947685
16	Hepatocellular necrosis (HP:0001404)	3.39344193
17	Elevated erythrocyte sedimentation rate (HP:0003565)	3.29146444
18	Increased CSF lactate (HP:0002490)	3.26252537
19	Increased hepatocellular lipid droplets (HP:0006565)	3.17247780
20	Congenital stationary night blindness (HP:0007642)	3.13112944
21	Abnormality of B cell number (HP:0010975)	3.11128203
22	Acute encephalopathy (HP:0006846)	3.10230261
23	Progressive macrocephaly (HP:0004481)	3.08825860
24	Renal Fanconi syndrome (HP:0001994)	3.06152544
25	Thyroiditis (HP:0100646)	3.04284061
26	Combined immunodeficiency (HP:0005387)	3.03572221
27	Abnormality of eosinophils (HP:0001879)	3.01042318
28	Hepatic necrosis (HP:0002605)	2.94674942
29	Increased muscle lipid content (HP:0009058)	2.92661290
30	Lipid accumulation in hepatocytes (HP:0006561)	2.91989917
31	Abnormality of the prostate (HP:0008775)	2.87154835
32	Chronic diarrhea (HP:0002028)	2.73795890
33	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.70140499
34	Cerebral edema (HP:0002181)	2.65702223
35	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.65477636
36	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.65477636
37	Abnormal rod and cone electroretinograms (HP:0008323)	2.63833433
38	Pancytopenia (HP:0001876)	2.58090438
39	Attenuation of retinal blood vessels (HP:0007843)	2.57577605
40	B lymphocytopenia (HP:0010976)	2.50430254
41	Lymphopenia (HP:0001888)	2.50047307
42	Eosinophilia (HP:0001880)	2.49699871
43	Pancreatic cysts (HP:0001737)	2.49660884
44	Constricted visual fields (HP:0001133)	2.44819410
45	Encephalitis (HP:0002383)	2.44264364
46	Abnormal albumin level (HP:0012116)	2.40697582
47	Hypoalbuminemia (HP:0003073)	2.40697582
48	Optic disc pallor (HP:0000543)	2.40140024
49	Abnormality of cells of the lymphoid lineage (HP:0012140)	2.38755760
50	Agammaglobulinemia (HP:0004432)	2.35793060
51	Oral leukoplakia (HP:0002745)	2.35702889
52	Recurrent cutaneous fungal infections (HP:0011370)	2.29292166
53	Chronic mucocutaneous candidiasis (HP:0002728)	2.29292166
54	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.28362860
55	Recurrent bronchitis (HP:0002837)	2.25213750
56	Meningitis (HP:0001287)	2.24498098
57	Abnormal number of erythroid precursors (HP:0012131)	2.23227038
58	Stomatitis (HP:0010280)	2.22994094
59	Panhypogammaglobulinemia (HP:0003139)	2.17862873
60	Abnormality of cells of the erythroid lineage (HP:0012130)	2.17087059
61	Leukocytosis (HP:0001974)	2.16153280
62	True hermaphroditism (HP:0010459)	2.15811658
63	Autoimmune thrombocytopenia (HP:0001973)	2.15106362
64	Obstructive lung disease (HP:0006536)	2.13433723
65	Chronic obstructive pulmonary disease (HP:0006510)	2.13433723
66	Increased serum lactate (HP:0002151)	2.13090881
67	IgM deficiency (HP:0002850)	2.12145906
68	Lactic acidosis (HP:0003128)	2.12093204
69	Severe visual impairment (HP:0001141)	2.10744630
70	Exertional dyspnea (HP:0002875)	2.09209972
71	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.07439585
72	Pancreatic fibrosis (HP:0100732)	2.06403158
73	Colon cancer (HP:0003003)	2.04622734
74	Reticulocytopenia (HP:0001896)	2.04167419
75	Hypoplasia of the thymus (HP:0000778)	2.02163003
76	Ureteral stenosis (HP:0000071)	1.99003896
77	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.98586399
78	Granulocytopenia (HP:0001913)	1.98566488
79	Absent thumb (HP:0009777)	1.97313308
80	Decreased central vision (HP:0007663)	1.95362796
81	Abnormality of T cell physiology (HP:0011840)	1.94941576
82	Abolished electroretinogram (ERG) (HP:0000550)	1.92579361
83	Methylmalonic aciduria (HP:0012120)	1.91540045
84	Respiratory failure (HP:0002878)	1.90693553
85	Generalized aminoaciduria (HP:0002909)	1.90667906
86	Lethargy (HP:0001254)	1.89862059
87	Molar tooth sign on MRI (HP:0002419)	1.89473668
88	Abnormality of midbrain morphology (HP:0002418)	1.89473668
89	Type I transferrin isoform profile (HP:0003642)	1.88470003
90	Abnormality of macrophages (HP:0004311)	1.87242739
91	Bronchitis (HP:0012387)	1.85104011
92	Lymphoma (HP:0002665)	1.84951799
93	Abnormality of renal resorption (HP:0011038)	1.84650045
94	Conical tooth (HP:0000698)	1.82594370
95	Methylmalonic acidemia (HP:0002912)	1.81564008
96	Exercise intolerance (HP:0003546)	1.80170230
97	Ureteral obstruction (HP:0006000)	1.79621416
98	Renal cortical cysts (HP:0000803)	1.79342551
99	Recurrent viral infections (HP:0004429)	1.76853929
100	Respiratory difficulties (HP:0002880)	1.75324616

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	KDR	5.80618963
2	TXK	5.31988269
3	TESK2	4.48941416
4	BCKDK	3.54846331
5	VRK2	3.45002727
6	TLK1	2.70668131
7	ZAK	2.62819734
8	MAP4K1	2.52776239
9	ITK	2.42382319
10	VRK1	2.30926123
11	ADRBK2	1.96570169
12	MUSK	1.94052763
13	TAOK3	1.87316738
14	TESK1	1.63113649
15	MAP3K12	1.53793674
16	MAP3K11	1.53776294
17	NUAK1	1.52530590
18	LIMK1	1.52512764
19	GRK1	1.47917131
20	SYK	1.47404607
21	PRKCQ	1.40146762
22	TEC	1.40096263
23	BUB1	1.34753645
24	PASK	1.32516026
25	GRK6	1.30752861
26	FES	1.27832673
27	SCYL2	1.27120371
28	TNK2	1.18765702
29	MAP4K2	1.18522847
30	LCK	1.17659267
31	BTK	1.15978846
32	CSK	1.15377449
33	STK16	1.11085955
34	MST4	1.00742050
35	GRK7	0.98000119
36	FRK	0.94403912
37	PINK1	0.91672901
38	IKBKB	0.91012483
39	CAMKK2	0.89110870
40	NME1	0.87059284
41	RPS6KA5	0.87017841
42	LYN	0.86772942
43	IKBKE	0.83724630
44	WNK4	0.82399029
45	INSRR	0.81688246
46	CAMKK1	0.81648264
47	ZAP70	0.78490028
48	TRPM7	0.78345664
49	KIT	0.77370683
50	DAPK1	0.76422565
51	CDK19	0.76183665
52	DAPK3	0.71774137
53	PIM2	0.70933602
54	TIE1	0.68856471
55	MATK	0.68843158
56	AURKA	0.68512029
57	MYLK	0.66282786
58	ADRBK1	0.63296298
59	EIF2AK3	0.61261410
60	WNK3	0.60896024
61	CSF1R	0.58848074
62	OBSCN	0.56092269
63	PIK3CA	0.56052175
64	DAPK2	0.54183866
65	PIM1	0.53946398
66	DYRK2	0.53370050
67	PIK3CG	0.52454299
68	IGF1R	0.50464425
69	MAPK15	0.50416366
70	JAK3	0.49955137
71	ROCK1	0.49595741
72	TBK1	0.47343310
73	CSNK1G3	0.47315031
74	PLK4	0.47248269
75	FYN	0.46931619
76	OXSR1	0.45217232
77	MAPKAPK5	0.44790725
78	PRKCA	0.43614824
79	INSR	0.41988694
80	HCK	0.40676577
81	PRKACA	0.38846563
82	GRK5	0.37259269
83	MAPKAPK3	0.35498975
84	CAMK2A	0.35353702
85	ATR	0.33627054
86	LRRK2	0.33530998
87	MAP2K7	0.33027832
88	CSNK2A1	0.32427558
89	ABL1	0.31622750
90	TYRO3	0.31441749
91	PRKCD	0.31224752
92	CAMK1	0.30116485
93	CSNK1G2	0.29839878
94	RIPK4	0.28431168
95	PKN1	0.27230518
96	RPS6KA4	0.27061314
97	CSNK1G1	0.26756572
98	CSNK2A2	0.25987179
99	PDK2	0.24679841
100	CSNK1A1L	0.24425375

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	5.41208311
2	Proteasome_Homo sapiens_hsa03050	3.95074802
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.66540323
4	Graft-versus-host disease_Homo sapiens_hsa05332	3.29378103
5	Parkinsons disease_Homo sapiens_hsa05012	3.07837088
6	Ribosome_Homo sapiens_hsa03010	3.03709445
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.99558400
8	Allograft rejection_Homo sapiens_hsa05330	2.93831309
9	Antigen processing and presentation_Homo sapiens_hsa04612	2.92236333
10	Hematopoietic cell lineage_Homo sapiens_hsa04640	2.44600085
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.36629993
12	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.34329755
13	Alzheimers disease_Homo sapiens_hsa05010	2.01809460
14	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.95100114
15	RNA polymerase_Homo sapiens_hsa03020	1.91020336
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.89203487
17	Huntingtons disease_Homo sapiens_hsa05016	1.85251341
18	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.76262360
19	Asthma_Homo sapiens_hsa05310	1.69161530
20	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.68426623
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.61481689
22	Rheumatoid arthritis_Homo sapiens_hsa05323	1.61392137
23	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.50231096
24	Phototransduction_Homo sapiens_hsa04744	1.41651158
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.39659544
26	Protein export_Homo sapiens_hsa03060	1.32687327
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.23775422
28	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.19140666
29	Viral myocarditis_Homo sapiens_hsa05416	1.17882296
30	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.17642765
31	Homologous recombination_Homo sapiens_hsa03440	1.17149814
32	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.13840672
33	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.03007038
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.00543011
35	Nitrogen metabolism_Homo sapiens_hsa00910	0.98662773
36	Measles_Homo sapiens_hsa05162	0.98482658
37	Pyrimidine metabolism_Homo sapiens_hsa00240	0.93727840
38	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.92176182
39	Peroxisome_Homo sapiens_hsa04146	0.87451361
40	Linoleic acid metabolism_Homo sapiens_hsa00591	0.86721222
41	Malaria_Homo sapiens_hsa05144	0.78290314
42	Caffeine metabolism_Homo sapiens_hsa00232	0.74069117
43	Salmonella infection_Homo sapiens_hsa05132	0.71828319
44	Fanconi anemia pathway_Homo sapiens_hsa03460	0.70460872
45	Purine metabolism_Homo sapiens_hsa00230	0.70094387
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.67476409
47	Olfactory transduction_Homo sapiens_hsa04740	0.67156594
48	Retinol metabolism_Homo sapiens_hsa00830	0.66841828
49	DNA replication_Homo sapiens_hsa03030	0.66594649
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66301035
51	Butanoate metabolism_Homo sapiens_hsa00650	0.65774492
52	RNA degradation_Homo sapiens_hsa03018	0.61894894
53	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.61526070
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61492318
55	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.60724147
56	Shigellosis_Homo sapiens_hsa05131	0.59412119
57	Nucleotide excision repair_Homo sapiens_hsa03420	0.55041014
58	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.53154189
59	Mismatch repair_Homo sapiens_hsa03430	0.51754760
60	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.51754331
61	Alcoholism_Homo sapiens_hsa05034	0.51522033
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.51509677
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.51146868
64	Taste transduction_Homo sapiens_hsa04742	0.49202048
65	One carbon pool by folate_Homo sapiens_hsa00670	0.47506116
66	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.46067924
67	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.45995270
68	Propanoate metabolism_Homo sapiens_hsa00640	0.45638003
69	Nicotine addiction_Homo sapiens_hsa05033	0.45389719
70	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.45153710
71	Base excision repair_Homo sapiens_hsa03410	0.42874306
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42167816
73	Spliceosome_Homo sapiens_hsa03040	0.38889120
74	Metabolic pathways_Homo sapiens_hsa01100	0.38794565
75	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38378578
76	Herpes simplex infection_Homo sapiens_hsa05168	0.38213480
77	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.37854302
78	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.37199499
79	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34941003
80	Basal transcription factors_Homo sapiens_hsa03022	0.34459197
81	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.34023968
82	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.33644692
83	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.33449087
84	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.33271160
85	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.33165757
86	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.32329619
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.30842864
88	Tryptophan metabolism_Homo sapiens_hsa00380	0.30427618
89	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.30347641
90	Regulation of autophagy_Homo sapiens_hsa04140	0.29208555
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.28817067
92	Morphine addiction_Homo sapiens_hsa05032	0.24559698
93	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.23940074
94	Chemokine signaling pathway_Homo sapiens_hsa04062	0.23766248
95	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.23577858
96	HTLV-I infection_Homo sapiens_hsa05166	0.23250173
97	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.22880508
98	Leishmaniasis_Homo sapiens_hsa05140	0.21245905
99	Ether lipid metabolism_Homo sapiens_hsa00565	0.19161731
100	African trypanosomiasis_Homo sapiens_hsa05143	0.16296267

RPS26P15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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