RPS26P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)9.32779879
2pyrimidine ribonucleoside catabolic process (GO:0046133)9.19330173
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.42815087
4regulation of activation of Janus kinase activity (GO:0010533)5.55318668
5positive thymic T cell selection (GO:0045059)4.85841374
6positive T cell selection (GO:0043368)4.83934383
7negative regulation by host of viral transcription (GO:0043922)4.74054110
8pyrimidine nucleoside catabolic process (GO:0046135)4.65994547
9positive regulation of interleukin-8 secretion (GO:2000484)4.48593217
10eosinophil chemotaxis (GO:0048245)4.32299323
11maturation of SSU-rRNA (GO:0030490)4.17891778
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.02422478
13eosinophil migration (GO:0072677)3.91288861
14energy coupled proton transport, down electrochemical gradient (GO:0015985)3.85015944
15ATP synthesis coupled proton transport (GO:0015986)3.85015944
16positive regulation of calcium-mediated signaling (GO:0050850)3.83870553
17Arp2/3 complex-mediated actin nucleation (GO:0034314)3.77280027
18ribosomal small subunit assembly (GO:0000028)3.72279846
19negative T cell selection (GO:0043383)3.68920347
20T cell migration (GO:0072678)3.68522064
21negative regulation of T cell apoptotic process (GO:0070233)3.66882279
22DNA demethylation (GO:0080111)3.63811688
23regulation of interleukin-8 secretion (GO:2000482)3.61528020
24regulation of regulatory T cell differentiation (GO:0045589)3.59616035
25chaperone-mediated protein transport (GO:0072321)3.53227777
26negative regulation of viral genome replication (GO:0045071)3.52749762
27positive regulation of defense response to virus by host (GO:0002230)3.51957278
28negative regulation of mast cell activation (GO:0033004)3.51095171
29regulation of T cell receptor signaling pathway (GO:0050856)3.50339254
30actin nucleation (GO:0045010)3.50054831
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.49178486
32macrophage chemotaxis (GO:0048246)3.47600880
33regulation of B cell receptor signaling pathway (GO:0050855)3.43954753
34cellular response to interleukin-15 (GO:0071350)3.43748482
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.42768199
36regulation of lymphocyte chemotaxis (GO:1901623)3.37643979
37DNA dealkylation (GO:0035510)3.36469365
38thymic T cell selection (GO:0045061)3.32298779
39metallo-sulfur cluster assembly (GO:0031163)3.31089462
40iron-sulfur cluster assembly (GO:0016226)3.31089462
41cytolysis (GO:0019835)3.30237530
42regulation of chronic inflammatory response (GO:0002676)3.30185657
43protein neddylation (GO:0045116)3.28805946
44ribosomal small subunit biogenesis (GO:0042274)3.27992306
45pyrimidine-containing compound catabolic process (GO:0072529)3.23831929
46negative regulation of B cell proliferation (GO:0030889)3.23803393
47positive regulation of T cell apoptotic process (GO:0070234)3.23688532
48positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.23390051
49positive regulation of lymphocyte migration (GO:2000403)3.21877339
50respiratory electron transport chain (GO:0022904)3.18848372
51positive regulation of tolerance induction (GO:0002645)3.18354914
52sequestering of actin monomers (GO:0042989)3.15769922
53electron transport chain (GO:0022900)3.15122989
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.13461338
55pyrimidine ribonucleoside metabolic process (GO:0046131)3.05690083
56negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.05621324
57negative regulation of lymphocyte apoptotic process (GO:0070229)3.05019327
58positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.04277014
59positive regulation of T cell mediated cytotoxicity (GO:0001916)3.04011066
60regulation of T cell tolerance induction (GO:0002664)2.98656362
61regulation of T cell mediated cytotoxicity (GO:0001914)2.98537796
62T cell costimulation (GO:0031295)2.98146254
63positive regulation of natural killer cell mediated immunity (GO:0002717)2.96865667
64T cell selection (GO:0045058)2.96750053
65regulation of leukocyte mediated cytotoxicity (GO:0001910)2.95350260
66viral transcription (GO:0019083)2.95109838
67lymphocyte costimulation (GO:0031294)2.94500341
68positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.94437882
69positive regulation of B cell differentiation (GO:0045579)2.94244278
70regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.91242865
71T cell receptor signaling pathway (GO:0050852)2.88349877
72positive regulation of T cell chemotaxis (GO:0010820)2.85644022
73regulation of T cell chemotaxis (GO:0010819)2.85644022
74response to gravity (GO:0009629)2.85074406
75establishment of protein localization to mitochondrial membrane (GO:0090151)2.84825996
76protein complex biogenesis (GO:0070271)2.84587591
77regulation of natural killer cell mediated immunity (GO:0002715)2.83408188
78regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.83408188
79response to interleukin-15 (GO:0070672)2.80887113
80translational termination (GO:0006415)2.80862635
81positive regulation of gamma-delta T cell activation (GO:0046645)2.77491064
82proteasome assembly (GO:0043248)2.75101675
83positive regulation of cell killing (GO:0031343)2.73900162
84regulation of calcium-mediated signaling (GO:0050848)2.72982066
85translational elongation (GO:0006414)2.70852458
86regulation of cell killing (GO:0031341)2.70221462
87water-soluble vitamin biosynthetic process (GO:0042364)2.69398564
88negative thymic T cell selection (GO:0045060)2.69237084
89positive regulation of translational initiation (GO:0045948)2.65600359
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.62809699
91SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.62219601
92regulation of T cell apoptotic process (GO:0070232)2.61282763
93regulation of B cell differentiation (GO:0045577)2.59942685
94regulation of cellular amino acid metabolic process (GO:0006521)2.59673780
95platelet dense granule organization (GO:0060155)2.58748960
96negative regulation of cell killing (GO:0031342)2.58592448
97negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.58592448
98cytidine metabolic process (GO:0046087)10.4755584
99cytidine catabolic process (GO:0006216)10.4755584
100cytidine deamination (GO:0009972)10.4755584

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.66483659
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.19686352
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.24723234
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.52424980
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.17383696
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.16372394
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.99221399
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.78603610
9VDR_22108803_ChIP-Seq_LS180_Human2.73482476
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66369641
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57394901
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.25636457
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.24485326
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21835103
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19578451
16CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.18907151
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.18015626
18VDR_23849224_ChIP-Seq_CD4+_Human1.93497591
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88095045
20MYB_26560356_Chip-Seq_TH2_Human1.79464828
21IGF1R_20145208_ChIP-Seq_DFB_Human1.74432391
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72651713
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72212880
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70814806
25RUNX_20019798_ChIP-Seq_JUKART_Human1.69375078
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.65903068
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65698322
28FOXP3_21729870_ChIP-Seq_TREG_Human1.63448517
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61076729
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.60907800
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.60116702
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59082988
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.54655853
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51788245
35EZH2_22144423_ChIP-Seq_EOC_Human1.49294865
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48515412
37GATA3_26560356_Chip-Seq_TH2_Human1.45611744
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.44699867
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43084316
40TP53_22573176_ChIP-Seq_HFKS_Human1.42489810
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41303231
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39116341
43EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.38366807
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34980585
45GATA3_27048872_Chip-Seq_THYMUS_Human1.32086389
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30109801
47ZNF274_21170338_ChIP-Seq_K562_Hela1.28659064
48RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28537853
49TAF2_19829295_ChIP-Seq_ESCs_Human1.25535321
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23263227
51NANOG_20526341_ChIP-Seq_ESCs_Human1.20469876
52TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.20170527
53PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19676917
54BCL6_27268052_Chip-Seq_Bcells_Human1.18969089
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.18951198
56MYC_18940864_ChIP-ChIP_HL60_Human1.18370297
57NCOR_22424771_ChIP-Seq_293T_Human1.15244835
58AR_20517297_ChIP-Seq_VCAP_Human1.15156509
59MYB_26560356_Chip-Seq_TH1_Human1.14575259
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13711635
61PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.09426203
62UTX_26944678_Chip-Seq_JUKART_Human1.09300593
63ELK1_19687146_ChIP-ChIP_HELA_Human1.07361645
64MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03379103
65STAT1_20625510_ChIP-Seq_HELA_Human1.01167056
66HTT_18923047_ChIP-ChIP_STHdh_Human1.00481876
67P300_27268052_Chip-Seq_Bcells_Human1.00335319
68YY1_22570637_ChIP-Seq_MALME-3M_Human0.99669110
69IRF8_21731497_ChIP-ChIP_J774_Mouse0.98696607
70HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97328962
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96934025
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96652962
73PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96463249
74SOX2_19829295_ChIP-Seq_ESCs_Human0.95702051
75NANOG_19829295_ChIP-Seq_ESCs_Human0.95702051
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95084494
77MAF_26560356_Chip-Seq_TH2_Human0.95071740
78TAF15_26573619_Chip-Seq_HEK293_Human0.94884053
79CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93876306
80YY1_21170310_ChIP-Seq_MESCs_Mouse0.93855725
81EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.93815235
82BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.93648758
83FOXH1_21741376_ChIP-Seq_EPCs_Human0.92305629
84CTCF_20526341_ChIP-Seq_ESCs_Human0.91985145
85GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91204358
86FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90620051
87FOXA1_25329375_ChIP-Seq_VCAP_Human0.90620051
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90179781
89ERG_20517297_ChIP-Seq_VCAP_Human0.89147090
90MYC_19829295_ChIP-Seq_ESCs_Human0.88687867
91GATA3_21878914_ChIP-Seq_MCF-7_Human0.88373979
92AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88092259
93BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86789635
94ERA_21632823_ChIP-Seq_H3396_Human0.86561189
95FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85935303
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85599292
97MYC_18555785_ChIP-Seq_MESCs_Mouse0.85227809
98CIITA_25753668_ChIP-Seq_RAJI_Human0.85014192
99CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85013732
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.84545521

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.75686742
2MP0009333_abnormal_splenocyte_physiolog3.55556168
3MP0004145_abnormal_muscle_electrophysio3.14451780
4MP0003763_abnormal_thymus_physiology2.92247288
5MP0009379_abnormal_foot_pigmentation2.88737301
6MP0009785_altered_susceptibility_to2.74332225
7MP0001835_abnormal_antigen_presentation2.67930727
8MP0002148_abnormal_hypersensitivity_rea2.53859231
9MP0003786_premature_aging2.34375201
10MP0006082_CNS_inflammation2.28562141
11MP0005000_abnormal_immune_tolerance2.27905508
12MP0002723_abnormal_immune_serum2.12699014
13MP0002420_abnormal_adaptive_immunity2.11377147
14MP0001819_abnormal_immune_cell2.05995850
15MP0001800_abnormal_humoral_immune2.05947983
16MP0003646_muscle_fatigue2.02994495
17MP0005025_abnormal_response_to2.01557886
18MP0002163_abnormal_gland_morphology2.01525465
19MP0002138_abnormal_hepatobiliary_system1.95131109
20MP0003806_abnormal_nucleotide_metabolis1.88679174
21MP0001790_abnormal_immune_system1.81722846
22MP0005387_immune_system_phenotype1.81722846
23MP0003866_abnormal_defecation1.72227344
24MP0000372_irregular_coat_pigmentation1.71091561
25MP0002452_abnormal_antigen_presenting1.68022215
26MP0005389_reproductive_system_phenotype1.62672138
27MP0000716_abnormal_immune_system1.62345408
28MP0002102_abnormal_ear_morphology1.59698130
29MP0001919_abnormal_reproductive_system1.58689318
30MP0001661_extended_life_span1.49455809
31MP0002398_abnormal_bone_marrow1.48428859
32MP0000703_abnormal_thymus_morphology1.44620597
33MP0002876_abnormal_thyroid_physiology1.44367860
34MP0000685_abnormal_immune_system1.43606216
35MP0001905_abnormal_dopamine_level1.41938645
36MP0001873_stomach_inflammation1.40221160
37MP0005645_abnormal_hypothalamus_physiol1.39622529
38MP0008872_abnormal_physiological_respon1.35698006
39MP0005083_abnormal_biliary_tract1.34544112
40MP0005379_endocrine/exocrine_gland_phen1.33455654
41MP0002166_altered_tumor_susceptibility1.32763345
42MP0001485_abnormal_pinna_reflex1.32423843
43MP0002722_abnormal_immune_system1.31298947
44MP0001968_abnormal_touch/_nociception1.29696391
45MP0003878_abnormal_ear_physiology1.28693739
46MP0005377_hearing/vestibular/ear_phenot1.28693739
47MP0006036_abnormal_mitochondrial_physio1.28212433
48MP0001188_hyperpigmentation1.26205248
49MP0002419_abnormal_innate_immunity1.25526536
50MP0002160_abnormal_reproductive_system1.23560379
51MP0010155_abnormal_intestine_physiology1.22755320
52MP0002405_respiratory_system_inflammati1.22230160
53MP0002277_abnormal_respiratory_mucosa1.20596640
54MP0002429_abnormal_blood_cell1.20561876
55MP0010307_abnormal_tumor_latency1.20350568
56MP0005075_abnormal_melanosome_morpholog1.20072955
57MP0004036_abnormal_muscle_relaxation1.18838284
58MP0005646_abnormal_pituitary_gland1.18107194
59MP0002837_dystrophic_cardiac_calcinosis1.18037399
60MP0002095_abnormal_skin_pigmentation1.16673551
61MP0005410_abnormal_fertilization1.16267185
62MP0006072_abnormal_retinal_apoptosis1.13748980
63MP0001845_abnormal_inflammatory_respons1.13127088
64MP0000689_abnormal_spleen_morphology1.10462627
65MP0003045_fibrosis1.09921169
66MP0002006_tumorigenesis1.03153367
67MP0008469_abnormal_protein_level0.99380300
68MP0009764_decreased_sensitivity_to0.99010655
69MP0006276_abnormal_autonomic_nervous0.98784956
70MP0004147_increased_porphyrin_level0.98659467
71MP0002736_abnormal_nociception_after0.93523922
72MP0005551_abnormal_eye_electrophysiolog0.93153861
73MP0002269_muscular_atrophy0.92404979
74MP0008873_increased_physiological_sensi0.91881321
75MP0003137_abnormal_impulse_conducting0.90891423
76MP0008875_abnormal_xenobiotic_pharmacok0.88766324
77MP0003448_altered_tumor_morphology0.87704419
78MP0000749_muscle_degeneration0.87500252
79MP0005084_abnormal_gallbladder_morpholo0.86998390
80MP0009763_increased_sensitivity_to0.85751629
81MP0003252_abnormal_bile_duct0.82464864
82MP0009765_abnormal_xenobiotic_induced0.82318096
83MP0005166_decreased_susceptibility_to0.80998262
84MP0009745_abnormal_behavioral_response0.80530493
85MP0002693_abnormal_pancreas_physiology0.79680537
86MP0005174_abnormal_tail_pigmentation0.77815480
87MP0002933_joint_inflammation0.77367612
88MP0001765_abnormal_ion_homeostasis0.76812291
89MP0004043_abnormal_pH_regulation0.76612835
90MP0003436_decreased_susceptibility_to0.74885058
91MP0005636_abnormal_mineral_homeostasis0.74330661
92MP0004381_abnormal_hair_follicle0.72803950
93MP0008007_abnormal_cellular_replicative0.72800697
94MP0002733_abnormal_thermal_nociception0.72401688
95MP0006292_abnormal_olfactory_placode0.71545098
96MP0005253_abnormal_eye_physiology0.70653474
97MP0002638_abnormal_pupillary_reflex0.67908840
98MP0004142_abnormal_muscle_tone0.67814870
99MP0003011_delayed_dark_adaptation0.66378079
100MP0003195_calcinosis0.64975440

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)5.27257878
2Acute necrotizing encephalopathy (HP:0006965)4.24632044
3Abnormality of T cell number (HP:0011839)4.22765472
4T lymphocytopenia (HP:0005403)4.21095429
5Abnormal mitochondria in muscle tissue (HP:0008316)4.04365116
6Aplastic anemia (HP:0001915)3.84647170
7Mitochondrial inheritance (HP:0001427)3.80363081
8Hypoproteinemia (HP:0003075)3.74015051
9Autoimmune hemolytic anemia (HP:0001890)3.72818954
10Progressive macrocephaly (HP:0004481)3.51777005
11Absent rod-and cone-mediated responses on ERG (HP:0007688)3.39390429
12IgG deficiency (HP:0004315)3.30807146
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.30398856
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.30398856
15Increased CSF lactate (HP:0002490)3.28912739
16Severe combined immunodeficiency (HP:0004430)3.27297716
17Acute encephalopathy (HP:0006846)3.26841837
18Hepatocellular necrosis (HP:0001404)3.03224742
19Abnormality of the prostate (HP:0008775)3.02081071
20Abnormality of T cells (HP:0002843)3.01416991
21Elevated erythrocyte sedimentation rate (HP:0003565)2.92751057
22Abolished electroretinogram (ERG) (HP:0000550)2.88906556
23Congenital stationary night blindness (HP:0007642)2.84398555
24Hepatic necrosis (HP:0002605)2.82744943
25Abnormality of eosinophils (HP:0001879)2.78612207
26Cerebral edema (HP:0002181)2.70160825
27Abnormality of B cell number (HP:0010975)2.65593519
28Absent phalangeal crease (HP:0006109)2.63826264
29Fibular aplasia (HP:0002990)2.61139046
30Decreased electroretinogram (ERG) amplitude (HP:0000654)2.60273208
31Abnormal rod and cone electroretinograms (HP:0008323)2.54077428
32Eosinophilia (HP:0001880)2.53368458
33Thyroiditis (HP:0100646)2.51699844
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.50738235
35Abnormality of alanine metabolism (HP:0010916)2.50738235
36Hyperalaninemia (HP:0003348)2.50738235
37Ureteral stenosis (HP:0000071)2.50516971
38Renal cortical cysts (HP:0000803)2.48780050
39Palpebral edema (HP:0100540)2.48736775
40Severe visual impairment (HP:0001141)2.45939376
41Increased serum lactate (HP:0002151)2.45699032
42Gastrointestinal infarctions (HP:0005244)2.45459284
43Combined immunodeficiency (HP:0005387)2.43456867
44Pancreatic cysts (HP:0001737)2.42296185
45Increased intramyocellular lipid droplets (HP:0012240)2.41610565
46Periorbital edema (HP:0100539)2.38568925
47Colon cancer (HP:0003003)2.35684493
48Optic disc pallor (HP:0000543)2.33168013
49Pendular nystagmus (HP:0012043)2.33110849
50Ureteral obstruction (HP:0006000)2.32932746
51Abnormal albumin level (HP:0012116)2.29831394
52Hypoalbuminemia (HP:0003073)2.29831394
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.29631620
54Chronic diarrhea (HP:0002028)2.28238678
55Abnormality of the renal cortex (HP:0011035)2.25030808
56Radial bowing (HP:0002986)2.23950267
57Facial edema (HP:0000282)2.23041458
58B lymphocytopenia (HP:0010976)2.22003906
59Attenuation of retinal blood vessels (HP:0007843)2.20661746
60Lactic acidosis (HP:0003128)2.20231116
61Symphalangism affecting the phalanges of the hand (HP:0009773)2.19474848
62Abnormality of the phalanges of the 2nd finger (HP:0009541)2.14960202
63Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.13764989
64Abnormal finger flexion creases (HP:0006143)2.12631741
65Nemaline bodies (HP:0003798)2.12283532
66Distal arthrogryposis (HP:0005684)2.12196123
67Autoimmune thrombocytopenia (HP:0001973)2.09556552
68Microretrognathia (HP:0000308)2.07047644
69Exercise intolerance (HP:0003546)2.02307704
70Increased muscle lipid content (HP:0009058)2.01632644
71Respiratory failure (HP:0002878)2.01594011
72Abnormality of the phalanges of the 5th finger (HP:0004213)1.97580840
73Leukocytosis (HP:0001974)1.96721449
74Stomatitis (HP:0010280)1.95983373
75Constricted visual fields (HP:0001133)1.92953547
76Granulocytopenia (HP:0001913)1.92101439
77Gangrene (HP:0100758)1.90648207
78Abnormality of midbrain morphology (HP:0002418)1.90212695
79Molar tooth sign on MRI (HP:0002419)1.90212695
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.89495675
81Increased IgM level (HP:0003496)1.88571527
82Encephalitis (HP:0002383)1.87585406
83Chest pain (HP:0100749)1.86772741
84Delayed CNS myelination (HP:0002188)1.85561143
85Recurrent bronchitis (HP:0002837)1.84424120
86Carpal bone hypoplasia (HP:0001498)1.83366215
87Lethargy (HP:0001254)1.81142966
88Pulmonary fibrosis (HP:0002206)1.79954997
89Abnormality of the middle phalanges of the toes (HP:0010183)1.78168540
90Abnormality of T cell physiology (HP:0011840)1.76717761
91Lymphopenia (HP:0001888)1.76709927
92Adactyly (HP:0009776)1.75603468
93Pigmentary retinal degeneration (HP:0001146)1.75182521
94Chronic obstructive pulmonary disease (HP:0006510)1.74546563
95Obstructive lung disease (HP:0006536)1.74546563
96Abnormality of the proximal phalanges of the hand (HP:0009834)1.74480269
97Abnormality of cells of the lymphoid lineage (HP:0012140)1.74295340
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72600618
99Aplasia/hypoplasia of the uterus (HP:0008684)1.71237455
100Type I transferrin isoform profile (HP:0003642)1.70751695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.37191171
2KDR4.97687153
3TESK23.54530065
4BUB13.39164756
5BCKDK2.80757099
6LIMK12.51253494
7MAP4K12.46572695
8STK162.43900011
9TLK12.43882261
10ADRBK22.41561907
11VRK22.17903330
12TIE12.17342287
13SCYL22.15760443
14ITK2.01501587
15TAOK31.98785702
16MAP4K21.94073740
17MUSK1.92142627
18ZAK1.86867456
19NUAK11.77760844
20FES1.69990017
21MAP3K121.61996028
22GRK11.59706062
23PIK3CA1.54064228
24WNK41.52505407
25PRKCQ1.40370049
26OBSCN1.36127716
27GRK61.31696337
28MST41.29295911
29SYK1.26350924
30PHKG21.19667291
31PHKG11.19667291
32CSK1.18321528
33FRK1.11829443
34IKBKB1.07797675
35TESK11.07140120
36JAK31.05082521
37LCK1.04341715
38PIK3CG1.04148073
39SRPK11.00975359
40MAP3K110.99242174
41VRK10.96825744
42IKBKE0.94314934
43ZAP700.89136240
44BMPR1B0.86128378
45RIPK40.83239566
46BTK0.82545581
47EIF2AK30.81838137
48GRK70.80971514
49PASK0.79526146
50DAPK10.79358404
51TEC0.78539326
52LYN0.78483008
53PIM20.76687643
54BLK0.72843736
55MYLK0.70656043
56INSRR0.70497131
57RPS6KA50.67946212
58AURKA0.66871320
59CAMKK20.66784724
60TYRO30.65296111
61MATK0.65266387
62DAPK20.64753101
63TBK10.62942836
64PINK10.61022542
65ADRBK10.57510643
66DYRK20.52695629
67CSF1R0.50426578
68BMPR20.49996144
69NEK10.49137464
70OXSR10.47425677
71CCNB10.46528936
72ARAF0.44239712
73TAF10.42766605
74MAPK130.41231827
75ATR0.40270453
76CSNK1G30.40161670
77FYN0.39792909
78PRKCA0.39354034
79CAMKK10.39028900
80IGF1R0.38989166
81PLK40.38715017
82PIM10.38293706
83MARK30.36693871
84PRKACA0.35886348
85CHEK20.35174462
86CDK40.35157815
87KIT0.34000413
88CSNK2A10.32041967
89TNK20.31608507
90DAPK30.31389821
91ABL20.31224055
92GRK50.30823238
93ROCK10.29901472
94CDK80.29486871
95CSNK2A20.29206134
96MAP2K60.27612455
97CAMK2G0.26888048
98CLK10.26125608
99PDK20.25904629
100ILK0.24340905

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.31731533
2Graft-versus-host disease_Homo sapiens_hsa053323.87299866
3Proteasome_Homo sapiens_hsa030503.67685242
4Ribosome_Homo sapiens_hsa030103.66447174
5Autoimmune thyroid disease_Homo sapiens_hsa053203.36442097
6Allograft rejection_Homo sapiens_hsa053303.35173140
7Oxidative phosphorylation_Homo sapiens_hsa001903.30957163
8Antigen processing and presentation_Homo sapiens_hsa046123.00575653
9Parkinsons disease_Homo sapiens_hsa050122.84961604
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.68352842
11Type I diabetes mellitus_Homo sapiens_hsa049402.64122787
12RNA polymerase_Homo sapiens_hsa030202.27968261
13Asthma_Homo sapiens_hsa053102.20689542
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.14927215
15Hematopoietic cell lineage_Homo sapiens_hsa046402.11313472
16Alzheimers disease_Homo sapiens_hsa050101.93651429
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.87410817
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79610193
19Rheumatoid arthritis_Homo sapiens_hsa053231.77439952
20Huntingtons disease_Homo sapiens_hsa050161.76422991
21T cell receptor signaling pathway_Homo sapiens_hsa046601.64882546
22Cardiac muscle contraction_Homo sapiens_hsa042601.52754865
23Viral myocarditis_Homo sapiens_hsa054161.39852121
24Nitrogen metabolism_Homo sapiens_hsa009101.37917391
25Protein export_Homo sapiens_hsa030601.34241020
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34068289
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33966791
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.21021626
29Phototransduction_Homo sapiens_hsa047441.18346168
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13970130
31Pyrimidine metabolism_Homo sapiens_hsa002401.09892627
32Systemic lupus erythematosus_Homo sapiens_hsa053221.05496512
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.04261135
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03322279
35RNA degradation_Homo sapiens_hsa030180.99289823
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97775262
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92410238
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86245386
39Regulation of autophagy_Homo sapiens_hsa041400.84964872
40One carbon pool by folate_Homo sapiens_hsa006700.83571829
41Measles_Homo sapiens_hsa051620.82573417
42Purine metabolism_Homo sapiens_hsa002300.81064255
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79091068
44Staphylococcus aureus infection_Homo sapiens_hsa051500.78696681
45Linoleic acid metabolism_Homo sapiens_hsa005910.74021826
46Homologous recombination_Homo sapiens_hsa034400.73021467
47Peroxisome_Homo sapiens_hsa041460.72374441
48Caffeine metabolism_Homo sapiens_hsa002320.68166924
49Salmonella infection_Homo sapiens_hsa051320.66823009
50Spliceosome_Homo sapiens_hsa030400.62369806
51Herpes simplex infection_Homo sapiens_hsa051680.60374587
52Malaria_Homo sapiens_hsa051440.59349690
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58448139
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56223699
55Nucleotide excision repair_Homo sapiens_hsa034200.55037522
56Olfactory transduction_Homo sapiens_hsa047400.53780668
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53236843
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52775220
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52355779
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51270725
61Butanoate metabolism_Homo sapiens_hsa006500.50261084
62Tryptophan metabolism_Homo sapiens_hsa003800.47501346
63DNA replication_Homo sapiens_hsa030300.46661247
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45540973
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.45178962
66Epstein-Barr virus infection_Homo sapiens_hsa051690.44804161
67Leishmaniasis_Homo sapiens_hsa051400.43839964
68Retinol metabolism_Homo sapiens_hsa008300.43304364
69Base excision repair_Homo sapiens_hsa034100.41469618
70Shigellosis_Homo sapiens_hsa051310.40790363
71Nicotine addiction_Homo sapiens_hsa050330.40182345
72Propanoate metabolism_Homo sapiens_hsa006400.39086537
73Chemical carcinogenesis_Homo sapiens_hsa052040.38985325
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38498781
75Arachidonic acid metabolism_Homo sapiens_hsa005900.36429323
76Legionellosis_Homo sapiens_hsa051340.36314509
77Fanconi anemia pathway_Homo sapiens_hsa034600.35301653
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.35275232
79Metabolic pathways_Homo sapiens_hsa011000.32673947
80HTLV-I infection_Homo sapiens_hsa051660.32153215
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31686502
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30482838
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29909024
84Sulfur metabolism_Homo sapiens_hsa009200.29170468
85Morphine addiction_Homo sapiens_hsa050320.27008311
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26735358
87Basal transcription factors_Homo sapiens_hsa030220.23745617
88Calcium signaling pathway_Homo sapiens_hsa040200.23653433
89Chemokine signaling pathway_Homo sapiens_hsa040620.22681609
90Fat digestion and absorption_Homo sapiens_hsa049750.22629493
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.20915284
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19548786
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19164599
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18942412
95RNA transport_Homo sapiens_hsa030130.18617500
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17214583
97Collecting duct acid secretion_Homo sapiens_hsa049660.16811549
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14700015
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.14041729
100Salivary secretion_Homo sapiens_hsa049700.14028510

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