ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of glucose import (GO:0046325)	7.68346284
2	interleukin-6-mediated signaling pathway (GO:0070102)	6.27507969
3	negative regulation of glucose transport (GO:0010829)	6.26130765
4	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	6.22534242
5	cellular response to ethanol (GO:0071361)	5.86795995
6	spermatid nucleus differentiation (GO:0007289)	5.70029255
7	regulation of glucose import in response to insulin stimulus (GO:2001273)	5.29737174
8	acrosome assembly (GO:0001675)	5.29219922
9	endothelial cell morphogenesis (GO:0001886)	5.14182890
10	ER overload response (GO:0006983)	5.04176451
11	muscle organ morphogenesis (GO:0048644)	4.87566543
12	glyoxylate metabolic process (GO:0046487)	4.59702779
13	protein maturation by protein folding (GO:0022417)	4.48088912
14	histone H3-K4 trimethylation (GO:0080182)	4.35667543
15	aldehyde catabolic process (GO:0046185)	4.26023903
16	ear development (GO:0043583)	4.20817384
17	positive regulation of mitochondrial fission (GO:0090141)	4.17021296
18	positive regulation of protein homooligomerization (GO:0032464)	4.08594244
19	vascular smooth muscle contraction (GO:0014829)	4.07975225
20	signal peptide processing (GO:0006465)	4.06103998
21	regulation of cilium movement (GO:0003352)	3.92815932
22	rRNA methylation (GO:0031167)	3.91836009
23	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	3.70817333
24	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	3.64914583
25	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	3.64914583
26	proteasome assembly (GO:0043248)	3.59929454
27	fusion of sperm to egg plasma membrane (GO:0007342)	3.58827061
28	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.57867169
29	brain morphogenesis (GO:0048854)	3.56062817
30	positive regulation of phosphatase activity (GO:0010922)	3.54445096
31	sperm motility (GO:0030317)	3.44892236
32	endocrine hormone secretion (GO:0060986)	3.42421743
33	histone mRNA catabolic process (GO:0071044)	3.38009917
34	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.31543572
35	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.31543572
36	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.31543572
37	tyrosine phosphorylation of STAT protein (GO:0007260)	3.30599751
38	blood vessel maturation (GO:0001955)	3.29493221
39	regulation of cardiac muscle cell contraction (GO:0086004)	3.25900817
40	piRNA metabolic process (GO:0034587)	3.21535451
41	regulation of vasculogenesis (GO:2001212)	3.17874350
42	platelet dense granule organization (GO:0060155)	3.17529977
43	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.16611741
44	cellular response to interleukin-6 (GO:0071354)	3.16452599
45	labyrinthine layer development (GO:0060711)	3.15388333
46	ketone body metabolic process (GO:1902224)	3.13723461
47	regulation of sarcomere organization (GO:0060297)	3.07043334
48	lipopolysaccharide biosynthetic process (GO:0009103)	3.06444568
49	developmental pigmentation (GO:0048066)	3.05669476
50	transcription from mitochondrial promoter (GO:0006390)	3.03227044
51	regulation of Rac protein signal transduction (GO:0035020)	3.03196454
52	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.01995148
53	rRNA modification (GO:0000154)	3.01429452
54	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.01101694
55	cellular ketone body metabolic process (GO:0046950)	3.00567154
56	positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)	2.99885917
57	response to caffeine (GO:0031000)	2.97659313
58	plasma membrane fusion (GO:0045026)	2.97203229
59	response to redox state (GO:0051775)	2.96809656
60	regulation of MHC class I biosynthetic process (GO:0045343)	2.95778284
61	natural killer cell activation involved in immune response (GO:0002323)	2.94806361
62	positive regulation of steroid hormone secretion (GO:2000833)	2.93678045
63	definitive hemopoiesis (GO:0060216)	2.93064124
64	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.92243164
65	positive regulation of glycolytic process (GO:0045821)	2.91883908
66	regulation of integrin-mediated signaling pathway (GO:2001044)	2.88240687
67	histone-serine phosphorylation (GO:0035404)	2.87482207
68	peptidyl-histidine modification (GO:0018202)	2.86069381
69	growth hormone receptor signaling pathway (GO:0060396)	2.85492963
70	ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)	2.83780220
71	endothelial cell proliferation (GO:0001935)	2.83664153
72	nonmotile primary cilium assembly (GO:0035058)	2.82597268
73	cellular response to BMP stimulus (GO:0071773)	2.82585333
74	response to BMP (GO:0071772)	2.82585333
75	multicellular organism reproduction (GO:0032504)	2.81237367
76	negative regulation of endothelial cell proliferation (GO:0001937)	2.80976869
77	chondrocyte proliferation (GO:0035988)	2.80212781
78	regulation of cytokine secretion involved in immune response (GO:0002739)	2.79076528
79	peptidyl-lysine trimethylation (GO:0018023)	2.76327145
80	regulation of sister chromatid cohesion (GO:0007063)	2.75655314
81	establishment of protein localization to Golgi (GO:0072600)	2.74059316
82	endothelium development (GO:0003158)	2.73862256
83	paraxial mesoderm development (GO:0048339)	2.71960250
84	intracellular pH reduction (GO:0051452)	2.71148319
85	muscle cell cellular homeostasis (GO:0046716)	2.70674756
86	negative regulation of cellular response to insulin stimulus (GO:1900077)	2.67165941
87	NIK/NF-kappaB signaling (GO:0038061)	2.66926242
88	establishment of epithelial cell polarity (GO:0090162)	2.66720680
89	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.64573948
90	response to hydroperoxide (GO:0033194)	2.64441491
91	axoneme assembly (GO:0035082)	2.64025594
92	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.63823025
93	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.63823025
94	epithelial cell morphogenesis (GO:0003382)	2.61773383
95	negative regulation of systemic arterial blood pressure (GO:0003085)	2.59963799
96	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	2.59925747
97	glycosylceramide metabolic process (GO:0006677)	2.59781682
98	secondary metabolite biosynthetic process (GO:0044550)	2.58918389
99	protein targeting to Golgi (GO:0000042)	2.58658983
100	snRNA transcription (GO:0009301)	2.57183591

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.62067374
2	SMAD_19615063_ChIP-ChIP_OVARY_Human	3.28521277
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.91109648
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.76552200
5	VDR_22108803_ChIP-Seq_LS180_Human	2.73733671
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.39189792
7	FUS_26573619_Chip-Seq_HEK293_Human	2.14173558
8	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.11769191
9	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.09838481
10	BCAT_22108803_ChIP-Seq_LS180_Human	2.01855667
11	ELK1_19687146_ChIP-ChIP_HELA_Human	1.98105981
12	P300_19829295_ChIP-Seq_ESCs_Human	1.96261637
13	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.94762387
14	ER_23166858_ChIP-Seq_MCF-7_Human	1.85667697
15	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.83882203
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.75722591
17	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.73925559
18	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.72471354
19	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.70911967
20	EWS_26573619_Chip-Seq_HEK293_Human	1.70019878
21	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.68773791
22	GBX2_23144817_ChIP-Seq_PC3_Human	1.66347859
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.65702705
24	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.64453144
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.63160952
26	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.58741726
27	CBP_20019798_ChIP-Seq_JUKART_Human	1.58741726
28	GATA1_22025678_ChIP-Seq_K562_Human	1.57204419
29	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.55326459
30	CJUN_26792858_Chip-Seq_BT549_Human	1.54813984
31	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.54080301
32	TCF4_22108803_ChIP-Seq_LS180_Human	1.51908822
33	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.48525765
34	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.48091356
35	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.47074913
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.46004194
37	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.45725224
38	GATA3_26560356_Chip-Seq_TH2_Human	1.44994395
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41928091
40	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.41406290
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.40368898
42	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.40156091
43	GATA3_26560356_Chip-Seq_TH1_Human	1.36744356
44	AR_25329375_ChIP-Seq_VCAP_Human	1.36356683
45	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.35885055
46	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.35456788
47	TCF4_23295773_ChIP-Seq_U87_Human	1.34741165
48	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.34735576
49	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.33791049
50	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.33735157
51	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.33168629
52	RUNX2_22187159_ChIP-Seq_PCA_Human	1.32859131
53	CDX2_22108803_ChIP-Seq_LS180_Human	1.32558675
54	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.31993251
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.31923033
56	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.30458702
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30429374
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.29639068
59	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.29309163
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.29268688
61	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.28574768
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.27424957
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.27424957
64	SMAD4_21799915_ChIP-Seq_A2780_Human	1.26189975
65	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.25911098
66	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.25629638
67	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.24633343
68	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23224870
69	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.20407684
70	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.20292640
71	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.20116267
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19638539
73	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.19464688
74	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.18701231
75	STAT3_23295773_ChIP-Seq_U87_Human	1.18616147
76	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.18329095
77	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.18238885
78	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.16798031
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.16538407
80	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.16490919
81	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16490919
82	AR_21572438_ChIP-Seq_LNCaP_Human	1.16211325
83	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.14996864
84	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.14364679
85	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.13660635
86	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.12125089
87	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.11833128
88	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.11466663
89	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.11466663
90	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.11466663
91	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.11166375
92	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.10397822
93	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09971551
94	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.09811438
95	IGF1R_20145208_ChIP-Seq_DFB_Human	1.08859451
96	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.07603307
97	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.05793060
98	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.05483083
99	VDR_23849224_ChIP-Seq_CD4+_Human	1.04453795
100	SMRT_27268052_Chip-Seq_Bcells_Human	1.04031914

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000015_abnormal_ear_pigmentation	4.89469449
2	MP0003950_abnormal_plasma_membrane	3.74990240
3	MP0000372_irregular_coat_pigmentation	3.57263805
4	MP0004036_abnormal_muscle_relaxation	2.83968637
5	MP0001879_abnormal_lymphatic_vessel	2.80406976
6	MP0005167_abnormal_blood-brain_barrier	2.73563168
7	MP0010368_abnormal_lymphatic_system	2.72706538
8	MP0004084_abnormal_cardiac_muscle	2.68936485
9	MP0006054_spinal_hemorrhage	2.62980729
10	MP0003941_abnormal_skin_development	2.44988443
11	MP0002095_abnormal_skin_pigmentation	2.43812446
12	MP0002736_abnormal_nociception_after	2.36099222
13	MP0005503_abnormal_tendon_morphology	2.30956885
14	MP0005551_abnormal_eye_electrophysiolog	2.25484681
15	MP0005174_abnormal_tail_pigmentation	2.17420534
16	MP0005075_abnormal_melanosome_morpholog	2.16840648
17	MP0001529_abnormal_vocalization	1.77698442
18	MP0003880_abnormal_central_pattern	1.74281361
19	MP0002254_reproductive_system_inflammat	1.73598368
20	MP0005410_abnormal_fertilization	1.73044095
21	MP0005310_abnormal_salivary_gland	1.70845396
22	MP0002102_abnormal_ear_morphology	1.65170531
23	MP0004808_abnormal_hematopoietic_stem	1.64116653
24	MP0005253_abnormal_eye_physiology	1.62761159
25	MP0004885_abnormal_endolymph	1.62084161
26	MP0001764_abnormal_homeostasis	1.55753711
27	MP0000371_diluted_coat_color	1.50568072
28	MP0006138_congestive_heart_failure	1.44806843
29	MP0003878_abnormal_ear_physiology	1.41139481
30	MP0005377_hearing/vestibular/ear_phenot	1.41139481
31	MP0005408_hypopigmentation	1.39374544
32	MP0003656_abnormal_erythrocyte_physiolo	1.35434717
33	MP0009697_abnormal_copulation	1.29517401
34	MP0000749_muscle_degeneration	1.28506394
35	MP0002653_abnormal_ependyma_morphology	1.28325394
36	MP0002138_abnormal_hepatobiliary_system	1.25938349
37	MP0000249_abnormal_blood_vessel	1.23939053
38	MP0001324_abnormal_eye_pigmentation	1.20970743
39	MP0008877_abnormal_DNA_methylation	1.19325413
40	MP0003385_abnormal_body_wall	1.17715877
41	MP0003718_maternal_effect	1.16825777
42	MP0005171_absent_coat_pigmentation	1.14707068
43	MP0005409_darkened_coat_color	1.14412940
44	MP0001501_abnormal_sleep_pattern	1.11381129
45	MP0005379_endocrine/exocrine_gland_phen	1.11268028
46	MP0005084_abnormal_gallbladder_morpholo	1.10786630
47	MP0003724_increased_susceptibility_to	1.09832802
48	MP0001485_abnormal_pinna_reflex	1.09766600
49	MP0003943_abnormal_hepatobiliary_system	1.07278451
50	MP0009840_abnormal_foam_cell	1.07189895
51	MP0002127_abnormal_cardiovascular_syste	1.03463693
52	MP0001915_intracranial_hemorrhage	1.02625494
53	MP0001968_abnormal_touch/_nociception	1.02075990
54	MP0001929_abnormal_gametogenesis	1.00223565
55	MP0002210_abnormal_sex_determination	0.99799046
56	MP0002177_abnormal_outer_ear	0.99757664
57	MP0000733_abnormal_muscle_development	0.99524518
58	MP0004215_abnormal_myocardial_fiber	0.98929696
59	MP0004134_abnormal_chest_morphology	0.98301409
60	MP0000569_abnormal_digit_pigmentation	0.98194216
61	MP0001853_heart_inflammation	0.92584941
62	MP0008260_abnormal_autophagy	0.90569337
63	MP0005671_abnormal_response_to	0.89805901
64	MP0002734_abnormal_mechanical_nocicepti	0.89805250
65	MP0008775_abnormal_heart_ventricle	0.89378347
66	MP0004145_abnormal_muscle_electrophysio	0.88643325
67	MP0001486_abnormal_startle_reflex	0.88518604
68	MP0005332_abnormal_amino_acid	0.88171704
69	MP0002148_abnormal_hypersensitivity_rea	0.88139157
70	MP0003698_abnormal_male_reproductive	0.86092536
71	MP0000427_abnormal_hair_cycle	0.82026597
72	MP0004270_analgesia	0.81696018
73	MP0001919_abnormal_reproductive_system	0.79950769
74	MP0005595_abnormal_vascular_smooth	0.77944266
75	MP0009764_decreased_sensitivity_to	0.77502188
76	MP0002837_dystrophic_cardiac_calcinosis	0.76174644
77	MP0002277_abnormal_respiratory_mucosa	0.75191334
78	MP0006035_abnormal_mitochondrial_morpho	0.74996607
79	MP0004742_abnormal_vestibular_system	0.71694440
80	MP0002132_abnormal_respiratory_system	0.71660488
81	MP0002938_white_spotting	0.71408395
82	MP0001348_abnormal_lacrimal_gland	0.67650379
83	MP0008004_abnormal_stomach_pH	0.65931833
84	MP0002332_abnormal_exercise_endurance	0.65237552
85	MP0004142_abnormal_muscle_tone	0.65064761
86	MP0002075_abnormal_coat/hair_pigmentati	0.64277394
87	MP0005620_abnormal_muscle_contractility	0.63680275
88	MP0002972_abnormal_cardiac_muscle	0.61198847
89	MP0002090_abnormal_vision	0.60654856
90	MP0003633_abnormal_nervous_system	0.60515408
91	MP0005367_renal/urinary_system_phenotyp	0.58128352
92	MP0000516_abnormal_urinary_system	0.58128352
93	MP0005395_other_phenotype	0.57562026
94	MP0005195_abnormal_posterior_eye	0.56557922
95	MP0001727_abnormal_embryo_implantation	0.55927179
96	MP0001544_abnormal_cardiovascular_syste	0.55349641
97	MP0005385_cardiovascular_system_phenoty	0.55349641
98	MP0001849_ear_inflammation	0.55178258
99	MP0008872_abnormal_physiological_respon	0.54540441
100	MP0003868_abnormal_feces_composition	0.54446117

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	5.39035900
2	Nonimmune hydrops fetalis (HP:0001790)	4.79621312
3	Global brain atrophy (HP:0002283)	4.56992918
4	Type I transferrin isoform profile (HP:0003642)	4.37432863
5	Albinism (HP:0001022)	4.25552169
6	Cutaneous melanoma (HP:0012056)	3.52502764
7	Chronic hepatic failure (HP:0100626)	3.52227942
8	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.51371192
9	Abnormal protein N-linked glycosylation (HP:0012347)	3.51371192
10	Abnormal protein glycosylation (HP:0012346)	3.51371192
11	Abnormal glycosylation (HP:0012345)	3.51371192
12	Keratoconus (HP:0000563)	3.29549134
13	Increased corneal curvature (HP:0100692)	3.29549134
14	Nuclear cataract (HP:0100018)	3.27437920
15	Abnormality of the pons (HP:0007361)	3.24472699
16	Abnormal pupillary function (HP:0007686)	3.13825996
17	Hypoplasia of the pons (HP:0012110)	3.12456749
18	Spontaneous abortion (HP:0005268)	3.10296157
19	Pancreatic cysts (HP:0001737)	3.01788293
20	Spastic paraparesis (HP:0002313)	2.96436455
21	Curly hair (HP:0002212)	2.94466592
22	Abnormality of macular pigmentation (HP:0008002)	2.93314280
23	Congenital sensorineural hearing impairment (HP:0008527)	2.91246568
24	Thrombocytosis (HP:0001894)	2.91030346
25	Aortic aneurysm (HP:0004942)	2.88866262
26	Dyschromatopsia (HP:0007641)	2.88330711
27	Megaloblastic anemia (HP:0001889)	2.79505391
28	Reduced antithrombin III activity (HP:0001976)	2.78964840
29	Hyperglycinuria (HP:0003108)	2.76296807
30	Abnormality of the fovea (HP:0000493)	2.66917210
31	Glucose intolerance (HP:0000833)	2.58653416
32	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.58420991
33	Hypoplasia of the fovea (HP:0007750)	2.58420991
34	Acute hepatic failure (HP:0006554)	2.56459651
35	Aortic dissection (HP:0002647)	2.55418316
36	Portal hypertension (HP:0001409)	2.54989198
37	Vacuolated lymphocytes (HP:0001922)	2.50763263
38	Hyperventilation (HP:0002883)	2.48251036
39	Testicular atrophy (HP:0000029)	2.47991488
40	Molar tooth sign on MRI (HP:0002419)	2.41047843
41	Abnormality of midbrain morphology (HP:0002418)	2.41047843
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.38410692
43	Progressive sensorineural hearing impairment (HP:0000408)	2.36892120
44	Agammaglobulinemia (HP:0004432)	2.35355541
45	Cystic liver disease (HP:0006706)	2.35328960
46	Central scotoma (HP:0000603)	2.33603576
47	Median cleft lip (HP:0000161)	2.33127352
48	Ocular albinism (HP:0001107)	2.32816037
49	Abnormality of the hepatic vasculature (HP:0006707)	2.30720048
50	Abnormality of glycolysis (HP:0004366)	2.30563094
51	Abnormality of methionine metabolism (HP:0010901)	2.29650064
52	Decreased central vision (HP:0007663)	2.23595164
53	Pancreatic fibrosis (HP:0100732)	2.23491755
54	Generalized hypopigmentation (HP:0007513)	2.22857542
55	Occipital encephalocele (HP:0002085)	2.22379380
56	Chronic sinusitis (HP:0011109)	2.21830946
57	Hematochezia (HP:0002573)	2.21094662
58	Hypoalphalipoproteinemia (HP:0003233)	2.20352542
59	Abnormality of vision evoked potentials (HP:0000649)	2.19450672
60	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.18742436
61	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.16979655
62	True hermaphroditism (HP:0010459)	2.16286673
63	Abnormality of T cell physiology (HP:0011840)	2.16029295
64	Generalized aminoaciduria (HP:0002909)	2.15385843
65	Horizontal nystagmus (HP:0000666)	2.13699316
66	Recurrent pneumonia (HP:0006532)	2.08066545
67	Cystic hygroma (HP:0000476)	2.07928634
68	Abnormality of homocysteine metabolism (HP:0010919)	2.06831667
69	Homocystinuria (HP:0002156)	2.06831667
70	Peritonitis (HP:0002586)	2.05329282
71	Deep philtrum (HP:0002002)	2.03014939
72	Iris hypopigmentation (HP:0007730)	2.01734559
73	Increased serum pyruvate (HP:0003542)	2.00921798
74	Medial flaring of the eyebrow (HP:0010747)	2.00309774
75	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.99299357
76	Attenuation of retinal blood vessels (HP:0007843)	1.99111836
77	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.97826240
78	Proximal tubulopathy (HP:0000114)	1.97812981
79	Hyperlipoproteinemia (HP:0010980)	1.95822431
80	Congenital stationary night blindness (HP:0007642)	1.93744740
81	Hypoplastic ischia (HP:0003175)	1.91002225
82	Esotropia (HP:0000565)	1.90101484
83	Abnormal biliary tract physiology (HP:0012439)	1.88951561
84	Bile duct proliferation (HP:0001408)	1.88951561
85	Poor eye contact (HP:0000817)	1.87329876
86	Neutropenia (HP:0001875)	1.84987816
87	Dry hair (HP:0011359)	1.84608125
88	Cone-rod dystrophy (HP:0000548)	1.84179499
89	Hydroureter (HP:0000072)	1.81026211
90	Cerebral hemorrhage (HP:0001342)	1.81023335
91	Absent speech (HP:0001344)	1.80874169
92	Abnormality of glycine metabolism (HP:0010895)	1.79443952
93	Abnormality of serine family amino acid metabolism (HP:0010894)	1.79443952
94	Abnormality of liposaccharide metabolism (HP:0010968)	1.79332047
95	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.79332047
96	Abnormality of glycolipid metabolism (HP:0010969)	1.79332047
97	Aplasia/Hypoplasia of the macula (HP:0008059)	1.77810526
98	Prolonged partial thromboplastin time (HP:0003645)	1.75338997
99	Abnormality of vitamin B metabolism (HP:0004340)	1.74602957
100	Scotoma (HP:0000575)	1.73028764

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	5.72838748
2	BRSK2	4.71209780
3	CAMKK2	4.48390247
4	BMPR1B	3.69507829
5	FLT3	3.67254214
6	MAP3K12	3.13336368
7	PKN2	3.02812469
8	EIF2AK3	2.66447819
9	AKT3	2.61093274
10	CDK8	2.02974854
11	TEC	1.90952227
12	MUSK	1.88999497
13	INSRR	1.76844232
14	TGFBR1	1.76691049
15	IRAK2	1.73560672
16	GRK1	1.73019440
17	BRSK1	1.70538853
18	CAMKK1	1.66000521
19	IRAK1	1.60048636
20	FRK	1.58654036
21	IRAK4	1.53503155
22	MKNK2	1.49705048
23	PDK2	1.46342266
24	PAK3	1.45142839
25	MYLK	1.45091154
26	PIK3CG	1.40458813
27	TNIK	1.37239371
28	MET	1.36653138
29	ACVR1B	1.36096231
30	BCKDK	1.34378694
31	FER	1.27089569
32	CASK	1.25939039
33	PLK2	1.08755891
34	FGFR1	1.05561559
35	SIK3	0.90812745
36	STK38L	0.90171994
37	KIT	0.89123301
38	TLK1	0.87220916
39	IGF1R	0.83658157
40	CCNB1	0.80594244
41	ITK	0.79628030
42	NUAK1	0.78245102
43	EIF2AK1	0.77313106
44	PASK	0.76360920
45	MAPK11	0.76249285
46	TBK1	0.75726471
47	OXSR1	0.75053503
48	JAK3	0.75007881
49	EPHA4	0.73613445
50	PTK2B	0.71167205
51	ERBB4	0.68028202
52	PKN1	0.67540286
53	PLK4	0.65370682
54	MAPK13	0.62171742
55	PDK1	0.59845601
56	HCK	0.59738290
57	YES1	0.58712193
58	FES	0.58120231
59	TRIM28	0.57206603
60	MKNK1	0.55991189
61	PRKCE	0.53674886
62	TYK2	0.51889889
63	ADRBK2	0.47692221
64	MINK1	0.47378829
65	IKBKE	0.46654997
66	ABL1	0.46347230
67	MARK3	0.43045987
68	STK39	0.42987949
69	EGFR	0.42599079
70	EIF2AK2	0.41883863
71	CDK9	0.40333486
72	TGFBR2	0.38044961
73	ROCK1	0.37629960
74	CSNK1G2	0.37247169
75	CHUK	0.36762488
76	BCR	0.35904090
77	IKBKB	0.35629347
78	NLK	0.35498318
79	MAPKAPK5	0.33359753
80	SYK	0.33063586
81	MAP3K9	0.31764863
82	CSNK1G1	0.31171278
83	OBSCN	0.30869197
84	PRKAA2	0.29913063
85	SGK2	0.27684421
86	PRKG2	0.27452777
87	PBK	0.26349891
88	TXK	0.25609652
89	JAK2	0.25451140
90	BTK	0.24151073
91	MAPKAPK3	0.23471930
92	PDPK1	0.22720374
93	BMX	0.21274062
94	ABL2	0.20978894
95	RET	0.20561320
96	CAMK2B	0.18648350
97	MAP3K14	0.18589832
98	TAOK2	0.18317713
99	ERBB3	0.16727689
100	CSNK1A1	0.16360237

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	6.06779301
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.35165278
3	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.73576442
4	Basal transcription factors_Homo sapiens_hsa03022	2.68990993
5	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.43060847
6	Propanoate metabolism_Homo sapiens_hsa00640	2.43011439
7	Regulation of autophagy_Homo sapiens_hsa04140	2.20717343
8	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.07246521
9	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.05923171
10	Butanoate metabolism_Homo sapiens_hsa00650	2.05755976
11	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	2.02016763
12	Olfactory transduction_Homo sapiens_hsa04740	1.91312208
13	RNA polymerase_Homo sapiens_hsa03020	1.81315794
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.73951825
15	Fatty acid degradation_Homo sapiens_hsa00071	1.73616474
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.67655196
17	Phototransduction_Homo sapiens_hsa04744	1.61798440
18	Nitrogen metabolism_Homo sapiens_hsa00910	1.60107410
19	RNA degradation_Homo sapiens_hsa03018	1.56111457
20	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.54269955
21	Other glycan degradation_Homo sapiens_hsa00511	1.50221445
22	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.46269867
23	Fatty acid metabolism_Homo sapiens_hsa01212	1.46019846
24	Proteasome_Homo sapiens_hsa03050	1.40922049
25	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.37902860
26	Primary immunodeficiency_Homo sapiens_hsa05340	1.36518637
27	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.29048305
28	Sulfur metabolism_Homo sapiens_hsa00920	1.26741929
29	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.23303870
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.19133028
31	Circadian rhythm_Homo sapiens_hsa04710	1.16700665
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13431753
33	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.09708569
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.06384260
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.06099290
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.97094240
37	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.96519728
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.94931149
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93891993
40	Selenocompound metabolism_Homo sapiens_hsa00450	0.85299954
41	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.82597520
42	FoxO signaling pathway_Homo sapiens_hsa04068	0.82544279
43	Ether lipid metabolism_Homo sapiens_hsa00565	0.75289371
44	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.73501554
45	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.72540334
46	Homologous recombination_Homo sapiens_hsa03440	0.72069633
47	Pyruvate metabolism_Homo sapiens_hsa00620	0.67958894
48	Caffeine metabolism_Homo sapiens_hsa00232	0.66996067
49	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.66501055
50	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.65737519
51	Arginine and proline metabolism_Homo sapiens_hsa00330	0.65555099
52	PPAR signaling pathway_Homo sapiens_hsa03320	0.63481595
53	Renin-angiotensin system_Homo sapiens_hsa04614	0.62846290
54	One carbon pool by folate_Homo sapiens_hsa00670	0.62787364
55	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.61980457
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.61289335
57	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.59077178
58	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.58772545
59	African trypanosomiasis_Homo sapiens_hsa05143	0.58734649
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.58399207
61	Legionellosis_Homo sapiens_hsa05134	0.58049583
62	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.55095413
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.51983837
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.51890136
65	Prostate cancer_Homo sapiens_hsa05215	0.51583026
66	Complement and coagulation cascades_Homo sapiens_hsa04610	0.48945657
67	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.47906556
68	RNA transport_Homo sapiens_hsa03013	0.47412108
69	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.46626458
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43850949
71	Rheumatoid arthritis_Homo sapiens_hsa05323	0.43769775
72	Huntingtons disease_Homo sapiens_hsa05016	0.41986251
73	Steroid biosynthesis_Homo sapiens_hsa00100	0.41911558
74	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.41465714
75	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.41102999
76	Tyrosine metabolism_Homo sapiens_hsa00350	0.40438493
77	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.39293818
78	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.38938462
79	Purine metabolism_Homo sapiens_hsa00230	0.38702132
80	Calcium signaling pathway_Homo sapiens_hsa04020	0.38306303
81	Glutathione metabolism_Homo sapiens_hsa00480	0.37727311
82	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.36822645
83	Linoleic acid metabolism_Homo sapiens_hsa00591	0.36127092
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.35755421
85	TNF signaling pathway_Homo sapiens_hsa04668	0.34555132
86	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.33123406
87	Retinol metabolism_Homo sapiens_hsa00830	0.33112788
88	Collecting duct acid secretion_Homo sapiens_hsa04966	0.32777404
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.32154725
90	Fat digestion and absorption_Homo sapiens_hsa04975	0.31229675
91	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.30617969
92	Sphingolipid metabolism_Homo sapiens_hsa00600	0.30547547
93	Serotonergic synapse_Homo sapiens_hsa04726	0.30482269
94	Adherens junction_Homo sapiens_hsa04520	0.26770399
95	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.26339779
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.26034075
97	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.25076156
98	Nucleotide excision repair_Homo sapiens_hsa03420	0.24360086
99	Melanogenesis_Homo sapiens_hsa04916	0.22529273
100	Peroxisome_Homo sapiens_hsa04146	0.22181461

RPS26P21

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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