RPS26P28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)9.58069229
2cytidine metabolic process (GO:0046087)9.58069229
3cytidine catabolic process (GO:0006216)9.58069229
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.36611866
5DNA deamination (GO:0045006)8.32894933
6pyrimidine ribonucleoside catabolic process (GO:0046133)8.28378802
7Arp2/3 complex-mediated actin nucleation (GO:0034314)5.30656475
8actin nucleation (GO:0045010)4.94098861
9regulation of regulatory T cell differentiation (GO:0045589)4.90560230
10positive T cell selection (GO:0043368)4.90167351
11positive thymic T cell selection (GO:0045059)4.63453247
12positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.62186037
13negative regulation by host of viral transcription (GO:0043922)4.60927035
14eosinophil chemotaxis (GO:0048245)4.53848433
15positive regulation of natural killer cell mediated immunity (GO:0002717)4.53212381
16regulation of activation of Janus kinase activity (GO:0010533)4.48308500
17negative regulation of T cell apoptotic process (GO:0070233)4.46526792
18positive regulation of tolerance induction (GO:0002645)4.20510001
19positive regulation of interleukin-8 secretion (GO:2000484)4.19964304
20negative T cell selection (GO:0043383)4.17972888
21pyrimidine nucleoside catabolic process (GO:0046135)4.17628816
22cytolysis (GO:0019835)4.15394599
23positive regulation of calcium-mediated signaling (GO:0050850)4.14756611
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.14624418
25eosinophil migration (GO:0072677)4.11791166
26positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.09762759
27cellular response to interleukin-15 (GO:0071350)4.06322106
28negative regulation of viral genome replication (GO:0045071)3.97463153
29regulation of chronic inflammatory response (GO:0002676)3.96736945
30sequestering of actin monomers (GO:0042989)3.96234263
31regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.92611856
32regulation of natural killer cell mediated immunity (GO:0002715)3.92611856
33regulation of T cell tolerance induction (GO:0002664)3.87855485
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.80635925
35T cell migration (GO:0072678)3.78365223
36thymic T cell selection (GO:0045061)3.66644249
37protein neddylation (GO:0045116)3.65599303
38positive regulation of cell killing (GO:0031343)3.65301778
39regulation of leukocyte mediated cytotoxicity (GO:0001910)3.64808240
40positive regulation of defense response to virus by host (GO:0002230)3.63288152
41macrophage chemotaxis (GO:0048246)3.57257030
42regulation of B cell receptor signaling pathway (GO:0050855)3.56876451
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.54549312
44positive regulation of gamma-delta T cell activation (GO:0046645)3.53403661
45positive regulation of B cell differentiation (GO:0045579)3.44853638
46positive regulation of T cell mediated cytotoxicity (GO:0001916)3.39853868
47regulation of T cell receptor signaling pathway (GO:0050856)3.39303096
48regulation of isotype switching to IgG isotypes (GO:0048302)3.38267852
49regulation of lymphocyte chemotaxis (GO:1901623)3.37052126
50ribosomal small subunit assembly (GO:0000028)3.36947998
51positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.31525515
52ATP synthesis coupled proton transport (GO:0015986)3.31389914
53energy coupled proton transport, down electrochemical gradient (GO:0015985)3.31389914
54regulation of cellular amino acid metabolic process (GO:0006521)3.31249695
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.30545325
56regulation of cell killing (GO:0031341)3.30517152
57negative regulation of lymphocyte apoptotic process (GO:0070229)3.29762257
58regulation of T cell chemotaxis (GO:0010819)3.29683959
59positive regulation of T cell chemotaxis (GO:0010820)3.29683959
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.27803625
61respiratory electron transport chain (GO:0022904)3.25930759
62T cell selection (GO:0045058)3.24993886
63regulation of tolerance induction (GO:0002643)3.24656773
64regulation of interleukin-8 secretion (GO:2000482)3.24443829
65response to interleukin-15 (GO:0070672)3.23176097
66electron transport chain (GO:0022900)3.22168490
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.21561952
68regulation of gamma-delta T cell differentiation (GO:0045586)3.20316882
69positive regulation of T cell apoptotic process (GO:0070234)3.19313990
70negative thymic T cell selection (GO:0045060)3.18832998
71T cell receptor signaling pathway (GO:0050852)3.18810865
72regulation of B cell differentiation (GO:0045577)3.17811342
73intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.16426668
74signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.16426668
75signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.14816170
76signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.14816170
77signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.14816170
78T cell costimulation (GO:0031295)3.13713104
79negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.13518077
80lymphocyte costimulation (GO:0031294)3.13377839
81regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.07026657
82iron-sulfur cluster assembly (GO:0016226)3.06936129
83metallo-sulfur cluster assembly (GO:0031163)3.06936129
84regulation of T cell mediated cytotoxicity (GO:0001914)3.05737374
85positive regulation of lymphocyte migration (GO:2000403)3.04458740
86negative regulation of calcium ion transport into cytosol (GO:0010523)3.03253715
87positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.02825103
88regulation of calcium-mediated signaling (GO:0050848)3.01159253
89negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.99619608
90regulation of T cell apoptotic process (GO:0070232)2.98794477
91antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.98302760
92response to pheromone (GO:0019236)2.98069476
93signal transduction involved in DNA damage checkpoint (GO:0072422)2.97975512
94signal transduction involved in DNA integrity checkpoint (GO:0072401)2.97975512
95DNA demethylation (GO:0080111)2.97577612
96regulation of viral genome replication (GO:0045069)2.95273041
97regulation of interleukin-2 biosynthetic process (GO:0045076)2.94543950
98signal transduction involved in cell cycle checkpoint (GO:0072395)2.92769719
99pyrimidine-containing compound catabolic process (GO:0072529)2.88356347
100positive regulation of alpha-beta T cell proliferation (GO:0046641)2.85271724

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.23949762
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.14736040
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.11692440
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.53542615
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.30473562
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.21349127
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.97934505
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.97388861
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.96297362
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.76943237
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.72825325
12VDR_22108803_ChIP-Seq_LS180_Human2.67164698
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.61088981
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.51805007
15MYB_26560356_Chip-Seq_TH2_Human2.42357272
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.11103221
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.10994298
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06888250
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01574861
20IGF1R_20145208_ChIP-Seq_DFB_Human1.95471983
21VDR_23849224_ChIP-Seq_CD4+_Human1.91954086
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91904891
23RUNX_20019798_ChIP-Seq_JUKART_Human1.91483336
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.81549157
25GATA3_27048872_Chip-Seq_THYMUS_Human1.80490148
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75598294
27GATA3_26560356_Chip-Seq_TH2_Human1.75054767
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66403096
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62641499
30HTT_18923047_ChIP-ChIP_STHdh_Human1.56076122
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54933276
32ZNF274_21170338_ChIP-Seq_K562_Hela1.54841545
33MYB_26560356_Chip-Seq_TH1_Human1.53251925
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49792257
35EZH2_22144423_ChIP-Seq_EOC_Human1.49540619
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.49476381
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.46050163
38RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.38982292
39FOXP3_21729870_ChIP-Seq_TREG_Human1.37381216
40TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.37347093
41PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.34266180
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32971232
43PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.31363531
44NANOG_20526341_ChIP-Seq_ESCs_Human1.28313628
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28226894
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28177510
47UTX_26944678_Chip-Seq_JUKART_Human1.26587292
48AR_20517297_ChIP-Seq_VCAP_Human1.26270005
49EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.22709191
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22522914
51TP53_22573176_ChIP-Seq_HFKS_Human1.20541012
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19643721
53NCOR_22424771_ChIP-Seq_293T_Human1.19158964
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.17073641
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16667559
56MYC_18940864_ChIP-ChIP_HL60_Human1.16511007
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16015594
58TAF2_19829295_ChIP-Seq_ESCs_Human1.13064716
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.12620755
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12620755
61GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.11992151
62MAF_26560356_Chip-Seq_TH2_Human1.10883196
63ER_23166858_ChIP-Seq_MCF-7_Human1.09774973
64ELK1_19687146_ChIP-ChIP_HELA_Human1.09253178
65GATA6_21074721_ChIP-Seq_CACO-2_Human1.05240723
66BCL6_27268052_Chip-Seq_Bcells_Human1.04081650
67SOX2_19829295_ChIP-Seq_ESCs_Human1.03877732
68NANOG_19829295_ChIP-Seq_ESCs_Human1.03877732
69CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03481106
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03120051
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01774227
72CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00395337
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00215351
74CTCF_20526341_ChIP-Seq_ESCs_Human1.00000044
75NFE2_27457419_Chip-Seq_LIVER_Mouse0.99812125
76PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99771299
77POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99543362
78GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99535150
79FOXH1_21741376_ChIP-Seq_EPCs_Human0.99469437
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99443997
81AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98589453
82ERG_20517297_ChIP-Seq_VCAP_Human0.98392764
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96809669
84YY1_22570637_ChIP-Seq_MALME-3M_Human0.96370367
85GATA3_21878914_ChIP-Seq_MCF-7_Human0.95388866
86FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94091227
87ERA_21632823_ChIP-Seq_H3396_Human0.92891037
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91978435
89ELF1_20517297_ChIP-Seq_JURKAT_Human0.91913733
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91790104
91BCAT_22108803_ChIP-Seq_LS180_Human0.91737153
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90677926
93RBPJ_21746931_ChIP-Seq_IB4_Human0.90598396
94MAF_26560356_Chip-Seq_TH1_Human0.90424188
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89297118
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88834711
97CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88426037
98P300_27268052_Chip-Seq_Bcells_Human0.87966707
99MYC_19829295_ChIP-Seq_ESCs_Human0.87461076
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87350437

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.26844700
2MP0009785_altered_susceptibility_to3.58888105
3MP0009333_abnormal_splenocyte_physiolog3.25945323
4MP0001835_abnormal_antigen_presentation3.15202883
5MP0003763_abnormal_thymus_physiology3.11021735
6MP0001873_stomach_inflammation2.57087341
7MP0002102_abnormal_ear_morphology2.54817864
8MP0005000_abnormal_immune_tolerance2.46695584
9MP0002166_altered_tumor_susceptibility2.30652206
10MP0006082_CNS_inflammation2.30144113
11MP0000372_irregular_coat_pigmentation2.28328204
12MP0005025_abnormal_response_to2.25091015
13MP0001800_abnormal_humoral_immune2.24515537
14MP0003866_abnormal_defecation2.16085509
15MP0005387_immune_system_phenotype2.15592118
16MP0001790_abnormal_immune_system2.15592118
17MP0003878_abnormal_ear_physiology2.12175648
18MP0005377_hearing/vestibular/ear_phenot2.12175648
19MP0002420_abnormal_adaptive_immunity2.10343130
20MP0002148_abnormal_hypersensitivity_rea2.09479639
21MP0002723_abnormal_immune_serum2.08278908
22MP0003646_muscle_fatigue2.04438777
23MP0001819_abnormal_immune_cell2.01705847
24MP0005645_abnormal_hypothalamus_physiol1.93528721
25MP0002006_tumorigenesis1.81209523
26MP0000685_abnormal_immune_system1.80827690
27MP0009379_abnormal_foot_pigmentation1.66615837
28MP0000716_abnormal_immune_system1.64218833
29MP0001919_abnormal_reproductive_system1.64212454
30MP0002452_abnormal_antigen_presenting1.62548951
31MP0002405_respiratory_system_inflammati1.62497361
32MP0005075_abnormal_melanosome_morpholog1.58516557
33MP0002398_abnormal_bone_marrow1.57433545
34MP0000703_abnormal_thymus_morphology1.50168701
35MP0001905_abnormal_dopamine_level1.49268884
36MP0010155_abnormal_intestine_physiology1.49015458
37MP0008872_abnormal_physiological_respon1.43633172
38MP0006072_abnormal_retinal_apoptosis1.42228552
39MP0002933_joint_inflammation1.42187733
40MP0003786_premature_aging1.38625774
41MP0005551_abnormal_eye_electrophysiolog1.36092285
42MP0001845_abnormal_inflammatory_respons1.35269464
43MP0002722_abnormal_immune_system1.33622182
44MP0000689_abnormal_spleen_morphology1.33579296
45MP0004145_abnormal_muscle_electrophysio1.33161220
46MP0005389_reproductive_system_phenotype1.33006294
47MP0001485_abnormal_pinna_reflex1.32751212
48MP0001853_heart_inflammation1.30364121
49MP0002277_abnormal_respiratory_mucosa1.30085783
50MP0003448_altered_tumor_morphology1.27298238
51MP0002429_abnormal_blood_cell1.21087935
52MP0003045_fibrosis1.19513961
53MP0002163_abnormal_gland_morphology1.18874813
54MP0003806_abnormal_nucleotide_metabolis1.15956262
55MP0005646_abnormal_pituitary_gland1.15506720
56MP0002095_abnormal_skin_pigmentation1.14542180
57MP0002638_abnormal_pupillary_reflex1.12866712
58MP0002837_dystrophic_cardiac_calcinosis1.12704553
59MP0002419_abnormal_innate_immunity1.08271637
60MP0001968_abnormal_touch/_nociception1.03299970
61MP0002138_abnormal_hepatobiliary_system1.02896608
62MP0005253_abnormal_eye_physiology1.02659270
63MP0003011_delayed_dark_adaptation1.01848232
64MP0008469_abnormal_protein_level1.00691214
65MP0002693_abnormal_pancreas_physiology1.00553453
66MP0006036_abnormal_mitochondrial_physio0.97223585
67MP0003436_decreased_susceptibility_to0.95098326
68MP0004381_abnormal_hair_follicle0.90573157
69MP0004742_abnormal_vestibular_system0.87508269
70MP0002876_abnormal_thyroid_physiology0.84687637
71MP0009764_decreased_sensitivity_to0.84686923
72MP0008875_abnormal_xenobiotic_pharmacok0.84247356
73MP0010386_abnormal_urinary_bladder0.83526807
74MP0004885_abnormal_endolymph0.83477341
75MP0005379_endocrine/exocrine_gland_phen0.82399011
76MP0004147_increased_porphyrin_level0.82030614
77MP0005166_decreased_susceptibility_to0.81485245
78MP0001188_hyperpigmentation0.81225874
79MP0005636_abnormal_mineral_homeostasis0.80361651
80MP0009763_increased_sensitivity_to0.80033183
81MP0008995_early_reproductive_senescence0.78646324
82MP0002234_abnormal_pharynx_morphology0.78036218
83MP0001765_abnormal_ion_homeostasis0.76713166
84MP0009745_abnormal_behavioral_response0.76170605
85MP0002019_abnormal_tumor_incidence0.75313388
86MP0000678_abnormal_parathyroid_gland0.74855534
87MP0005410_abnormal_fertilization0.74192084
88MP0001984_abnormal_olfaction0.73993111
89MP0001986_abnormal_taste_sensitivity0.73857407
90MP0003137_abnormal_impulse_conducting0.73451365
91MP0005174_abnormal_tail_pigmentation0.73444711
92MP0004947_skin_inflammation0.70348911
93MP0002160_abnormal_reproductive_system0.70268360
94MP0005464_abnormal_platelet_physiology0.69673425
95MP0001661_extended_life_span0.69315629
96MP0003195_calcinosis0.68865174
97MP0002736_abnormal_nociception_after0.66139848
98MP0001119_abnormal_female_reproductive0.63524723
99MP0009643_abnormal_urine_homeostasis0.62877158
100MP0003880_abnormal_central_pattern0.59137819

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.58991503
2Abnormality of T cell number (HP:0011839)5.51408675
3Aplastic anemia (HP:0001915)5.03650197
4Autoimmune hemolytic anemia (HP:0001890)4.54829509
5IgG deficiency (HP:0004315)4.28389620
6Severe combined immunodeficiency (HP:0004430)4.16794055
7Elevated erythrocyte sedimentation rate (HP:0003565)4.16412385
8Hypoproteinemia (HP:0003075)4.11788718
9Mitochondrial inheritance (HP:0001427)4.00770829
10Renal Fanconi syndrome (HP:0001994)3.87804018
11Congenital stationary night blindness (HP:0007642)3.87645390
12Increased IgM level (HP:0003496)3.81687901
13Abnormality of B cell number (HP:0010975)3.80910585
14Abnormality of T cells (HP:0002843)3.73678516
15Increased intramyocellular lipid droplets (HP:0012240)3.73537005
16Acute necrotizing encephalopathy (HP:0006965)3.73080430
17Abnormal mitochondria in muscle tissue (HP:0008316)3.54130930
18Thyroiditis (HP:0100646)3.53413567
19Absent rod-and cone-mediated responses on ERG (HP:0007688)3.31374709
20Increased CSF lactate (HP:0002490)3.31200093
21Combined immunodeficiency (HP:0005387)3.26654821
22Increased hepatocellular lipid droplets (HP:0006565)3.24850579
23Hepatocellular necrosis (HP:0001404)3.20626667
243-Methylglutaconic aciduria (HP:0003535)3.18325238
25Abnormality of eosinophils (HP:0001879)3.14179301
26Generalized aminoaciduria (HP:0002909)3.13848655
27Chronic diarrhea (HP:0002028)3.09022125
28Increased muscle lipid content (HP:0009058)3.07272568
29B lymphocytopenia (HP:0010976)3.07211166
30Progressive macrocephaly (HP:0004481)3.07129854
31Acute encephalopathy (HP:0006846)2.94458539
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.91841320
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.91841320
34Hepatic necrosis (HP:0002605)2.88694117
35Autoimmune thrombocytopenia (HP:0001973)2.83703742
36Abnormality of the prostate (HP:0008775)2.80182087
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.76932316
38Abnormal rod and cone electroretinograms (HP:0008323)2.75984162
39Lipid accumulation in hepatocytes (HP:0006561)2.75667788
40Eosinophilia (HP:0001880)2.63498634
41Encephalitis (HP:0002383)2.55318543
42Stomatitis (HP:0010280)2.52905776
43Lymphopenia (HP:0001888)2.52449665
44Abnormality of cells of the lymphoid lineage (HP:0012140)2.49327278
45Cerebral edema (HP:0002181)2.49324214
46Optic disc pallor (HP:0000543)2.48835771
47Attenuation of retinal blood vessels (HP:0007843)2.48295528
48Decreased electroretinogram (ERG) amplitude (HP:0000654)2.42941958
49Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40057056
50Recurrent bronchitis (HP:0002837)2.38321333
51Pancreatic cysts (HP:0001737)2.36546510
52Exertional dyspnea (HP:0002875)2.33644220
53Leukocytosis (HP:0001974)2.32614396
54Hypoalbuminemia (HP:0003073)2.31225045
55Abnormal albumin level (HP:0012116)2.31225045
56Increased serum lactate (HP:0002151)2.21333977
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.19489681
58Recurrent cutaneous fungal infections (HP:0011370)2.19076461
59Chronic mucocutaneous candidiasis (HP:0002728)2.19076461
60Renal cortical cysts (HP:0000803)2.19020962
61Abnormality of renal resorption (HP:0011038)2.16236608
62Pancytopenia (HP:0001876)2.12900996
63Decreased central vision (HP:0007663)2.12260228
64Abnormality of T cell physiology (HP:0011840)2.09529309
65Lactic acidosis (HP:0003128)2.05930464
66Glycosuria (HP:0003076)2.05130361
67Abnormality of urine glucose concentration (HP:0011016)2.05130361
68Meningitis (HP:0001287)2.02276936
69Gastrointestinal infarctions (HP:0005244)2.02253168
70Abolished electroretinogram (ERG) (HP:0000550)2.01410984
71Severe visual impairment (HP:0001141)2.00694244
72Lymphoma (HP:0002665)1.99560083
73Abnormality of alanine metabolism (HP:0010916)1.99454288
74Hyperalaninemia (HP:0003348)1.99454288
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99454288
76IgM deficiency (HP:0002850)1.98260554
77Respiratory failure (HP:0002878)1.92875254
78Exercise intolerance (HP:0003546)1.92430757
79Recurrent otitis media (HP:0000403)1.91035683
80Granulocytopenia (HP:0001913)1.90889055
81Abnormal drinking behavior (HP:0030082)1.90373551
82Polydipsia (HP:0001959)1.90373551
83Gangrene (HP:0100758)1.90105129
84Pulmonary infiltrates (HP:0002113)1.89448019
85Constricted visual fields (HP:0001133)1.87643919
86Bronchitis (HP:0012387)1.86239762
87Vasculitis (HP:0002633)1.83648815
88Abnormality of macrophages (HP:0004311)1.79294784
89Hypergammaglobulinemia (HP:0010702)1.79132688
90Abnormality of midbrain morphology (HP:0002418)1.79107637
91Molar tooth sign on MRI (HP:0002419)1.79107637
92Obstructive lung disease (HP:0006536)1.78469421
93Chronic obstructive pulmonary disease (HP:0006510)1.78469421
94Agammaglobulinemia (HP:0004432)1.78276298
95Pancreatic fibrosis (HP:0100732)1.77816325
96Pendular nystagmus (HP:0012043)1.77734787
97Myositis (HP:0100614)1.77720729
98Recurrent viral infections (HP:0004429)1.76923227
99True hermaphroditism (HP:0010459)1.73636140
100Hemiplegia (HP:0002301)1.73003514

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.02635115
2TXK5.84172915
3TESK25.36733383
4ZAK2.82402641
5BCKDK2.69198717
6ITK2.59830709
7VRK22.31816526
8TLK12.25945182
9MAP4K12.24267190
10ADRBK22.11821662
11SCYL22.08686004
12BUB12.02695814
13GRK11.97756893
14TESK11.87318084
15MAP3K121.82138400
16LIMK11.80300911
17VRK11.78229300
18TAOK31.74483391
19MUSK1.69976303
20MST41.48214501
21TEC1.37442458
22FRK1.33064454
23PRKCQ1.30615571
24MAP3K111.28882739
25SYK1.26970495
26FES1.26689714
27CSK1.25829398
28PASK1.17962505
29GRK61.13987272
30LCK1.13891576
31STK161.10755871
32ZAP701.03784416
33PINK11.02992579
34EIF2AK31.02620835
35WNK41.01827082
36MAPKAPK30.99882942
37NUAK10.99881866
38GRK70.99547747
39BTK0.98331612
40MAP4K20.94687482
41IKBKE0.90044301
42KIT0.84566678
43CAMKK20.79670427
44NME10.78504379
45MYLK0.78485070
46LYN0.75862354
47INSRR0.74107323
48TRIM280.73904495
49CAMKK10.73468596
50IKBKB0.72426432
51TNK20.69892046
52DAPK10.68631103
53WNK30.67852455
54PIK3CA0.66565463
55PIM10.66488559
56TIE10.66004901
57MAP2K60.64311289
58TBK10.57080988
59ROCK10.56393900
60ADRBK10.55045597
61OBSCN0.53147589
62MAPK150.52566295
63FYN0.52493126
64TYRO30.52224332
65CSF1R0.52101645
66IGF1R0.51062094
67PLK40.50435880
68RPS6KA50.49622972
69PRKCH0.49109969
70CSNK1G30.48721116
71BMPR1B0.48150796
72JAK30.47333263
73MAP3K50.47145648
74WEE10.45022397
75DAPK30.42981096
76EIF2AK10.42584758
77MAPKAPK50.39358311
78PRKCA0.39338795
79OXSR10.39212324
80GRK50.38147797
81AURKA0.37872894
82MAP2K70.34394039
83PRKACA0.34358840
84CAMK2A0.34316552
85PIK3CG0.34257672
86INSR0.32867539
87CSNK1A1L0.31240094
88MATK0.31041056
89CSNK1G20.30050257
90CSNK1G10.29462172
91PDK20.29099495
92STK390.28452062
93BLK0.25901861
94PAK10.25831915
95CSNK2A10.25437906
96PRKCB0.22649015
97ATR0.22200199
98MARK30.21355424
99PLK20.21144807
100DAPK20.20909584

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.81249456
2Proteasome_Homo sapiens_hsa030504.83650927
3Oxidative phosphorylation_Homo sapiens_hsa001903.43314735
4Graft-versus-host disease_Homo sapiens_hsa053322.95149017
5Parkinsons disease_Homo sapiens_hsa050122.92644350
6Antigen processing and presentation_Homo sapiens_hsa046122.92401091
7Autoimmune thyroid disease_Homo sapiens_hsa053202.73529800
8Hematopoietic cell lineage_Homo sapiens_hsa046402.66144196
9Allograft rejection_Homo sapiens_hsa053302.52588683
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.51479989
11Ribosome_Homo sapiens_hsa030102.34775305
12T cell receptor signaling pathway_Homo sapiens_hsa046602.33167766
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.32417894
14Type I diabetes mellitus_Homo sapiens_hsa049402.09920644
15Alzheimers disease_Homo sapiens_hsa050101.96577499
16RNA polymerase_Homo sapiens_hsa030201.91813007
17Protein export_Homo sapiens_hsa030601.87808226
18Phototransduction_Homo sapiens_hsa047441.82961235
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.80155546
20Huntingtons disease_Homo sapiens_hsa050161.66186144
21Rheumatoid arthritis_Homo sapiens_hsa053231.64737282
22Cardiac muscle contraction_Homo sapiens_hsa042601.56620889
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40197260
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34634784
25Measles_Homo sapiens_hsa051621.34288704
26Nitrogen metabolism_Homo sapiens_hsa009101.26019035
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.16377790
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15491205
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12519277
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.11638388
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08840145
32Salmonella infection_Homo sapiens_hsa051321.05043420
33Linoleic acid metabolism_Homo sapiens_hsa005911.00330623
34Malaria_Homo sapiens_hsa051440.98166713
35Asthma_Homo sapiens_hsa053100.97693267
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96161935
37Viral myocarditis_Homo sapiens_hsa054160.92745788
38One carbon pool by folate_Homo sapiens_hsa006700.90472429
39Homologous recombination_Homo sapiens_hsa034400.87520840
40Caffeine metabolism_Homo sapiens_hsa002320.87159280
41Peroxisome_Homo sapiens_hsa041460.82556751
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81458194
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78712151
44Systemic lupus erythematosus_Homo sapiens_hsa053220.76415830
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74556833
46Olfactory transduction_Homo sapiens_hsa047400.73438064
47Pyrimidine metabolism_Homo sapiens_hsa002400.72464796
48RNA degradation_Homo sapiens_hsa030180.69990530
49Butanoate metabolism_Homo sapiens_hsa006500.68627461
50Shigellosis_Homo sapiens_hsa051310.67607488
51Purine metabolism_Homo sapiens_hsa002300.65972148
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.65765726
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64601697
54Retinol metabolism_Homo sapiens_hsa008300.63724962
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59724604
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58212183
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55157610
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.54955777
59Collecting duct acid secretion_Homo sapiens_hsa049660.53931344
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52416786
61Chemical carcinogenesis_Homo sapiens_hsa052040.50717236
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49012213
63Nucleotide excision repair_Homo sapiens_hsa034200.48187746
64Propanoate metabolism_Homo sapiens_hsa006400.45222248
65Sulfur metabolism_Homo sapiens_hsa009200.42162822
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.41097406
67Taste transduction_Homo sapiens_hsa047420.40820998
68Herpes simplex infection_Homo sapiens_hsa051680.40231457
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.39461152
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.38516373
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38388730
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35588419
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35086230
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34112549
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33779612
76Epstein-Barr virus infection_Homo sapiens_hsa051690.33403488
77Basal transcription factors_Homo sapiens_hsa030220.33168248
78Chemokine signaling pathway_Homo sapiens_hsa040620.32956430
79DNA replication_Homo sapiens_hsa030300.32925300
80Metabolic pathways_Homo sapiens_hsa011000.32815300
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.32390420
82Mismatch repair_Homo sapiens_hsa034300.31042718
83Nicotine addiction_Homo sapiens_hsa050330.30827194
84Fanconi anemia pathway_Homo sapiens_hsa034600.29915980
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29053442
86Tryptophan metabolism_Homo sapiens_hsa003800.27367020
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26186239
88Morphine addiction_Homo sapiens_hsa050320.23292780
89Arachidonic acid metabolism_Homo sapiens_hsa005900.22398103
90HTLV-I infection_Homo sapiens_hsa051660.21983080
91African trypanosomiasis_Homo sapiens_hsa051430.21805313
92Ether lipid metabolism_Homo sapiens_hsa005650.20833338
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20290359
94Base excision repair_Homo sapiens_hsa034100.19343170
95Staphylococcus aureus infection_Homo sapiens_hsa051500.17925202
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17406503
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.15325790
98Fat digestion and absorption_Homo sapiens_hsa049750.15267760
99Apoptosis_Homo sapiens_hsa042100.14914991
100Alcoholism_Homo sapiens_hsa050340.14034653

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