RPS26P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)9.13914354
2cytidine metabolic process (GO:0046087)8.64175702
3cytidine catabolic process (GO:0006216)8.64175702
4cytidine deamination (GO:0009972)8.64175702
5pyrimidine ribonucleoside catabolic process (GO:0046133)7.66288839
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.38542177
7positive regulation of interleukin-8 secretion (GO:2000484)5.05127129
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.39137959
9Arp2/3 complex-mediated actin nucleation (GO:0034314)4.25133627
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.19070637
11ATP synthesis coupled proton transport (GO:0015986)4.19070637
12regulation of regulatory T cell differentiation (GO:0045589)4.03738058
13regulation of interleukin-8 secretion (GO:2000482)3.94701385
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.91852536
15actin nucleation (GO:0045010)3.87069722
16negative regulation of T cell apoptotic process (GO:0070233)3.82821371
17sequestering of actin monomers (GO:0042989)3.81466479
18pyrimidine nucleoside catabolic process (GO:0046135)3.78027907
19ribosomal small subunit assembly (GO:0000028)3.75698429
20respiratory electron transport chain (GO:0022904)3.61167513
21electron transport chain (GO:0022900)3.55978994
22regulation of activation of Janus kinase activity (GO:0010533)3.53994690
23T cell migration (GO:0072678)3.53931286
24eosinophil chemotaxis (GO:0048245)3.52865140
25regulation of chronic inflammatory response (GO:0002676)3.48815066
26positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.45373014
27protein neddylation (GO:0045116)3.41921017
28positive thymic T cell selection (GO:0045059)3.41749234
29positive T cell selection (GO:0043368)3.41286828
30negative regulation by host of viral transcription (GO:0043922)3.40349991
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.39434937
32positive regulation of natural killer cell mediated immunity (GO:0002717)3.38368950
33regulation of cellular amino acid metabolic process (GO:0006521)3.35798811
34positive regulation of defense response to virus by host (GO:0002230)3.34418612
35cellular response to interleukin-15 (GO:0071350)3.34089215
36positive regulation of calcium-mediated signaling (GO:0050850)3.30345938
37cytolysis (GO:0019835)3.27523539
38negative regulation of viral genome replication (GO:0045071)3.27058734
39metallo-sulfur cluster assembly (GO:0031163)3.26600089
40iron-sulfur cluster assembly (GO:0016226)3.26600089
41platelet dense granule organization (GO:0060155)3.24740979
42eosinophil migration (GO:0072677)3.20151471
43positive regulation of tolerance induction (GO:0002645)3.19615946
44protein complex biogenesis (GO:0070271)3.17869828
45proteasome assembly (GO:0043248)3.17461837
46positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.16877999
47negative regulation of lymphocyte apoptotic process (GO:0070229)3.16349363
48behavioral response to nicotine (GO:0035095)3.14368197
49transcription elongation from RNA polymerase III promoter (GO:0006385)3.14354405
50termination of RNA polymerase III transcription (GO:0006386)3.14354405
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.14252211
52negative T cell selection (GO:0043383)3.14211435
53positive regulation of lymphocyte migration (GO:2000403)3.13350371
54regulation of T cell tolerance induction (GO:0002664)3.07212633
55positive regulation of T cell chemotaxis (GO:0010820)3.06497043
56regulation of T cell chemotaxis (GO:0010819)3.06497043
57regulation of isotype switching to IgG isotypes (GO:0048302)3.05102644
58regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.02862041
59negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02153577
60intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.01998058
61signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.01998058
62signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.01740796
63signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.01740796
64signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.01740796
65positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.00554406
66regulation of lymphocyte chemotaxis (GO:1901623)2.99709637
67chaperone-mediated protein transport (GO:0072321)2.98289133
68respiratory chain complex IV assembly (GO:0008535)2.97088905
69positive regulation of B cell differentiation (GO:0045579)2.96786695
70regulation of T cell receptor signaling pathway (GO:0050856)2.94285338
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.93545175
72DNA demethylation (GO:0080111)2.91271240
73mitochondrial respiratory chain complex assembly (GO:0033108)2.90758279
74regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.89767896
75regulation of natural killer cell mediated immunity (GO:0002715)2.89767896
76macrophage chemotaxis (GO:0048246)2.89634625
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.88975044
78response to interferon-beta (GO:0035456)2.88458370
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.86969773
80regulation of interleukin-2 biosynthetic process (GO:0045076)2.86928375
81positive regulation of cell killing (GO:0031343)2.86372270
82regulation of leukocyte mediated cytotoxicity (GO:0001910)2.84777468
83signal transduction involved in DNA integrity checkpoint (GO:0072401)2.84536837
84signal transduction involved in DNA damage checkpoint (GO:0072422)2.84536837
85pyrimidine ribonucleoside metabolic process (GO:0046131)2.83823391
86DNA dealkylation (GO:0035510)2.82150157
87signal transduction involved in cell cycle checkpoint (GO:0072395)2.81287081
88pyrimidine-containing compound catabolic process (GO:0072529)2.80662822
89positive regulation of T cell mediated cytotoxicity (GO:0001916)2.80280326
90positive regulation of T cell apoptotic process (GO:0070234)2.79548619
91T cell costimulation (GO:0031295)2.79108910
92nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78192550
93positive regulation of T cell migration (GO:2000406)2.76447437
94T cell receptor signaling pathway (GO:0050852)2.76242164
95positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.76118899
96positive regulation of monocyte chemotaxis (GO:0090026)2.75813310
97lymphocyte costimulation (GO:0031294)2.75812554
98mitochondrial respiratory chain complex I assembly (GO:0032981)2.74690588
99NADH dehydrogenase complex assembly (GO:0010257)2.74690588
100mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.74690588

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.04749622
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.28077500
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.90297926
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.67369700
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.47852889
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.12521514
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.08806399
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.93943934
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91868717
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.74919510
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.67810413
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67127836
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.65559031
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.39024652
15VDR_23849224_ChIP-Seq_CD4+_Human2.35058131
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.28405466
17VDR_22108803_ChIP-Seq_LS180_Human2.27137230
18ZNF274_21170338_ChIP-Seq_K562_Hela2.00250692
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96132302
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92570890
21FOXP3_21729870_ChIP-Seq_TREG_Human1.91349270
22MYB_26560356_Chip-Seq_TH2_Human1.90585343
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81965747
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.77367692
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73981371
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72856871
27YY1_21170310_ChIP-Seq_MESCs_Mouse1.69930695
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63996947
29IGF1R_20145208_ChIP-Seq_DFB_Human1.61910153
30RUNX_20019798_ChIP-Seq_JUKART_Human1.56449555
31GATA3_26560356_Chip-Seq_TH2_Human1.55521444
32EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.54727243
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52067649
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51025368
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50429468
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.47684341
37ELK1_19687146_ChIP-ChIP_HELA_Human1.47136084
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.46088523
39RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.45955770
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45807479
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.44284313
42EZH2_22144423_ChIP-Seq_EOC_Human1.43637898
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42566701
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40456652
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.40437967
46GATA3_27048872_Chip-Seq_THYMUS_Human1.38493803
47MYC_18940864_ChIP-ChIP_HL60_Human1.34732131
48TAF2_19829295_ChIP-Seq_ESCs_Human1.29711914
49PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27705313
50NANOG_20526341_ChIP-Seq_ESCs_Human1.26203627
51TP53_22573176_ChIP-Seq_HFKS_Human1.25765259
52NCOR_22424771_ChIP-Seq_293T_Human1.24324084
53AR_20517297_ChIP-Seq_VCAP_Human1.23264716
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23143805
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22682218
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21744405
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21316901
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.21316901
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21228828
60BCL6_27268052_Chip-Seq_Bcells_Human1.20129730
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18471438
62HTT_18923047_ChIP-ChIP_STHdh_Human1.16544630
63PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15395391
64MYC_18555785_ChIP-Seq_MESCs_Mouse1.13679062
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12768596
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12548295
67CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09757736
68MYB_26560356_Chip-Seq_TH1_Human1.09716818
69FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08780195
70TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07547951
71SOX2_19829295_ChIP-Seq_ESCs_Human1.06253554
72NANOG_19829295_ChIP-Seq_ESCs_Human1.06253554
73ERA_21632823_ChIP-Seq_H3396_Human1.04098442
74EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04064401
75AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02650349
76FOXH1_21741376_ChIP-Seq_EPCs_Human1.02203495
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02017536
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01446779
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00201847
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99303154
81GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99185631
82FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99085239
83GATA6_21074721_ChIP-Seq_CACO-2_Human0.98037296
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97984462
85NFE2_27457419_Chip-Seq_LIVER_Mouse0.97159389
86MYC_19829295_ChIP-Seq_ESCs_Human0.95029348
87GATA3_21878914_ChIP-Seq_MCF-7_Human0.94755806
88ELF1_20517297_ChIP-Seq_JURKAT_Human0.94412496
89P300_27268052_Chip-Seq_Bcells_Human0.94248020
90CTCF_20526341_ChIP-Seq_ESCs_Human0.93849396
91CIITA_25753668_ChIP-Seq_RAJI_Human0.93104310
92RBPJ_21746931_ChIP-Seq_IB4_Human0.92510379
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91783563
94EWS_26573619_Chip-Seq_HEK293_Human0.91506289
95ERG_20517297_ChIP-Seq_VCAP_Human0.91294802
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89306721
97GABP_19822575_ChIP-Seq_HepG2_Human0.89257285
98YY1_22570637_ChIP-Seq_MALME-3M_Human0.88971140
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88795874
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.88288381

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.57740311
2MP0001835_abnormal_antigen_presentation3.65236329
3MP0009785_altered_susceptibility_to3.05770858
4MP0009333_abnormal_splenocyte_physiolog2.99039374
5MP0002148_abnormal_hypersensitivity_rea2.54032447
6MP0003763_abnormal_thymus_physiology2.42514555
7MP0004145_abnormal_muscle_electrophysio2.22024911
8MP0005000_abnormal_immune_tolerance2.18940210
9MP0001873_stomach_inflammation2.07684329
10MP0001800_abnormal_humoral_immune2.03454435
11MP0002420_abnormal_adaptive_immunity2.00519112
12MP0009379_abnormal_foot_pigmentation1.96863482
13MP0005025_abnormal_response_to1.95034198
14MP0001819_abnormal_immune_cell1.93813634
15MP0003866_abnormal_defecation1.92922711
16MP0002723_abnormal_immune_serum1.92678711
17MP0005387_immune_system_phenotype1.90675365
18MP0001790_abnormal_immune_system1.90675365
19MP0001905_abnormal_dopamine_level1.86251295
20MP0002163_abnormal_gland_morphology1.82918941
21MP0002166_altered_tumor_susceptibility1.81825151
22MP0006082_CNS_inflammation1.69502022
23MP0005646_abnormal_pituitary_gland1.64314456
24MP0003786_premature_aging1.63324223
25MP0000685_abnormal_immune_system1.62773334
26MP0003646_muscle_fatigue1.56971196
27MP0008872_abnormal_physiological_respon1.56636815
28MP0002452_abnormal_antigen_presenting1.56164193
29MP0010155_abnormal_intestine_physiology1.52781109
30MP0000716_abnormal_immune_system1.51284073
31MP0004147_increased_porphyrin_level1.48689520
32MP0002006_tumorigenesis1.48688343
33MP0001968_abnormal_touch/_nociception1.48175038
34MP0000372_irregular_coat_pigmentation1.48090042
35MP0002398_abnormal_bone_marrow1.45113447
36MP0002405_respiratory_system_inflammati1.43915599
37MP0002933_joint_inflammation1.41542215
38MP0001919_abnormal_reproductive_system1.41427933
39MP0002277_abnormal_respiratory_mucosa1.40152661
40MP0005645_abnormal_hypothalamus_physiol1.39425542
41MP0002736_abnormal_nociception_after1.34392050
42MP0006292_abnormal_olfactory_placode1.33396507
43MP0008875_abnormal_xenobiotic_pharmacok1.33360635
44MP0005075_abnormal_melanosome_morpholog1.33124415
45MP0002837_dystrophic_cardiac_calcinosis1.30025992
46MP0005389_reproductive_system_phenotype1.29946648
47MP0006072_abnormal_retinal_apoptosis1.29105460
48MP0002102_abnormal_ear_morphology1.28939546
49MP0000703_abnormal_thymus_morphology1.28844543
50MP0006036_abnormal_mitochondrial_physio1.25703652
51MP0002722_abnormal_immune_system1.24647282
52MP0002638_abnormal_pupillary_reflex1.20805490
53MP0002876_abnormal_thyroid_physiology1.20719799
54MP0002138_abnormal_hepatobiliary_system1.19534192
55MP0000689_abnormal_spleen_morphology1.18490765
56MP0002429_abnormal_blood_cell1.18188976
57MP0003806_abnormal_nucleotide_metabolis1.17563591
58MP0003045_fibrosis1.17388491
59MP0001188_hyperpigmentation1.16547092
60MP0001845_abnormal_inflammatory_respons1.15506453
61MP0006276_abnormal_autonomic_nervous1.14041287
62MP0002822_catalepsy1.13902693
63MP0002095_abnormal_skin_pigmentation1.13582171
64MP0001853_heart_inflammation1.11642325
65MP0005253_abnormal_eye_physiology1.10621214
66MP0005551_abnormal_eye_electrophysiolog1.08928645
67MP0003011_delayed_dark_adaptation1.08756718
68MP0003195_calcinosis1.07923798
69MP0005379_endocrine/exocrine_gland_phen1.07411219
70MP0005084_abnormal_gallbladder_morpholo1.01705642
71MP0001542_abnormal_bone_strength1.01640397
72MP0001764_abnormal_homeostasis1.01141290
73MP0002419_abnormal_innate_immunity1.00012370
74MP0005410_abnormal_fertilization0.99893711
75MP0003880_abnormal_central_pattern0.99081121
76MP0004142_abnormal_muscle_tone0.98129455
77MP0002733_abnormal_thermal_nociception0.95098274
78MP0003448_altered_tumor_morphology0.94758345
79MP0008873_increased_physiological_sensi0.93452876
80MP0008469_abnormal_protein_level0.92351083
81MP0001661_extended_life_span0.91960754
82MP0009764_decreased_sensitivity_to0.91189495
83MP0003436_decreased_susceptibility_to0.91094985
84MP0003137_abnormal_impulse_conducting0.89941877
85MP0002693_abnormal_pancreas_physiology0.88406247
86MP0008058_abnormal_DNA_repair0.87909613
87MP0009763_increased_sensitivity_to0.87867259
88MP0009745_abnormal_behavioral_response0.86174840
89MP0001529_abnormal_vocalization0.83562577
90MP0001970_abnormal_pain_threshold0.83172227
91MP0008789_abnormal_olfactory_epithelium0.82514761
92MP0009765_abnormal_xenobiotic_induced0.81644649
93MP0002160_abnormal_reproductive_system0.80458798
94MP0003878_abnormal_ear_physiology0.79520074
95MP0005377_hearing/vestibular/ear_phenot0.79520074
96MP0004742_abnormal_vestibular_system0.79370137
97MP0010386_abnormal_urinary_bladder0.78231328
98MP0002132_abnormal_respiratory_system0.77421554
99MP0005636_abnormal_mineral_homeostasis0.75751998
100MP0006035_abnormal_mitochondrial_morpho0.75480397

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.45268218
2Mitochondrial inheritance (HP:0001427)4.49712825
3Acute necrotizing encephalopathy (HP:0006965)4.04321294
4T lymphocytopenia (HP:0005403)4.03153176
5Hepatocellular necrosis (HP:0001404)3.98501012
6Hypoproteinemia (HP:0003075)3.94872302
7Abnormality of T cell number (HP:0011839)3.91967275
8Increased hepatocellular lipid droplets (HP:0006565)3.90351098
9Increased CSF lactate (HP:0002490)3.90131930
10Increased intramyocellular lipid droplets (HP:0012240)3.84653713
11Abnormal mitochondria in muscle tissue (HP:0008316)3.81894763
12IgG deficiency (HP:0004315)3.77929072
13Renal Fanconi syndrome (HP:0001994)3.67436879
14Lipid accumulation in hepatocytes (HP:0006561)3.60427644
15Hepatic necrosis (HP:0002605)3.49083818
163-Methylglutaconic aciduria (HP:0003535)3.47474600
17Acute encephalopathy (HP:0006846)3.37362907
18Elevated erythrocyte sedimentation rate (HP:0003565)3.29389112
19Absent rod-and cone-mediated responses on ERG (HP:0007688)3.28331052
20Increased muscle lipid content (HP:0009058)3.26684031
21Progressive macrocephaly (HP:0004481)3.24598739
22Severe combined immunodeficiency (HP:0004430)3.23331486
23Autoimmune hemolytic anemia (HP:0001890)3.09627654
24Abnormality of the prostate (HP:0008775)3.08384012
25Cerebral edema (HP:0002181)2.92263761
26Increased serum lactate (HP:0002151)2.91895516
27Abnormality of T cells (HP:0002843)2.90767691
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.86782097
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.86782097
30Pancreatic cysts (HP:0001737)2.85933554
31Molar tooth sign on MRI (HP:0002419)2.82091911
32Abnormality of midbrain morphology (HP:0002418)2.82091911
33Congenital stationary night blindness (HP:0007642)2.72844560
34Exertional dyspnea (HP:0002875)2.68876966
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.68358428
36Abnormality of eosinophils (HP:0001879)2.68140007
37Lactic acidosis (HP:0003128)2.61862208
38Increased IgM level (HP:0003496)2.59479375
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.55343374
40Optic disc pallor (HP:0000543)2.54343499
41Decreased central vision (HP:0007663)2.52823266
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.49341479
43Thyroiditis (HP:0100646)2.48074674
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.46807169
45Pancytopenia (HP:0001876)2.45521048
46Abolished electroretinogram (ERG) (HP:0000550)2.41376148
47Abnormal rod and cone electroretinograms (HP:0008323)2.39710361
48Combined immunodeficiency (HP:0005387)2.38936149
49Hypoalbuminemia (HP:0003073)2.36432117
50Abnormal albumin level (HP:0012116)2.36432117
51Attenuation of retinal blood vessels (HP:0007843)2.33363017
52Methylmalonic acidemia (HP:0002912)2.31614477
53Constricted visual fields (HP:0001133)2.30268582
54Chronic mucocutaneous candidiasis (HP:0002728)2.28058961
55Recurrent cutaneous fungal infections (HP:0011370)2.28058961
56True hermaphroditism (HP:0010459)2.27501065
57Encephalitis (HP:0002383)2.26419373
58Chronic diarrhea (HP:0002028)2.22982934
59Hyperalaninemia (HP:0003348)2.19284664
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19284664
61Abnormality of alanine metabolism (HP:0010916)2.19284664
62Exercise intolerance (HP:0003546)2.18720465
63Eosinophilia (HP:0001880)2.15964508
64Generalized aminoaciduria (HP:0002909)2.15794241
65Pancreatic fibrosis (HP:0100732)2.14533736
66Type 2 muscle fiber atrophy (HP:0003554)2.14253614
67Chronic obstructive pulmonary disease (HP:0006510)2.12079131
68Obstructive lung disease (HP:0006536)2.12079131
69Respiratory failure (HP:0002878)2.11383804
70Lethargy (HP:0001254)2.11117955
71Panhypogammaglobulinemia (HP:0003139)2.08289495
72Stomatitis (HP:0010280)2.07571051
73Abnormality of renal resorption (HP:0011038)2.06476315
74Respiratory difficulties (HP:0002880)2.03811595
75Microretrognathia (HP:0000308)2.01121336
76Agammaglobulinemia (HP:0004432)2.00191166
77Pendular nystagmus (HP:0012043)1.99886875
78Ureteral stenosis (HP:0000071)1.99770481
79Methylmalonic aciduria (HP:0012120)1.97613889
80Oral leukoplakia (HP:0002745)1.93663712
81Meningitis (HP:0001287)1.89291929
82Aplasia/hypoplasia of the uterus (HP:0008684)1.88372659
83Pulmonary fibrosis (HP:0002206)1.87821002
84Muscle fiber atrophy (HP:0100295)1.87058248
85Leukocytosis (HP:0001974)1.86197969
86Gangrene (HP:0100758)1.84085363
87Hyperphosphaturia (HP:0003109)1.84025769
88Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81410288
89Dicarboxylic aciduria (HP:0003215)1.81410288
90Ureteral obstruction (HP:0006000)1.80991866
91Type I transferrin isoform profile (HP:0003642)1.80641125
92Abnormality of B cell number (HP:0010975)1.80357735
93Recurrent bronchitis (HP:0002837)1.79835147
94Ketosis (HP:0001946)1.78931094
95Hemiplegia (HP:0002301)1.76755643
96Glycosuria (HP:0003076)1.76147640
97Abnormality of urine glucose concentration (HP:0011016)1.76147640
98Chest pain (HP:0100749)1.74786139
99Abnormality of T cell physiology (HP:0011840)1.72860246
100Pulmonary infiltrates (HP:0002113)1.70750823

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.73735390
2KDR4.60187512
3TESK24.20616760
4BCKDK3.65735701
5VRK23.46069656
6MAP4K12.40953979
7NUAK12.26178515
8ITK2.22500333
9ADRBK21.99864124
10BUB11.96632062
11FES1.88999514
12TLK11.84015162
13ZAK1.83410519
14MAP3K121.77166141
15TESK11.69418521
16STK161.69362773
17LIMK11.66844569
18GRK11.66023489
19VRK11.65319211
20EIF2AK31.53031854
21MUSK1.42424750
22TRIM281.37529761
23PRKCQ1.36454090
24MAP3K111.32843916
25SYK1.28107832
26MAPKAPK31.17432830
27LCK1.15687509
28MAP4K21.15608432
29MST41.11821635
30BMPR1B1.11715167
31TEC1.10720325
32IKBKB1.08267470
33WNK41.06027710
34CSK1.03852690
35IKBKE0.98418011
36CSNK1G30.98177227
37DAPK10.97629063
38SCYL20.95992416
39DYRK20.95882131
40GRK70.94832161
41GRK60.94469752
42MAPKAPK50.93465944
43TAOK30.91773571
44BTK0.90864324
45TIE10.89243487
46CAMKK20.88833233
47PIK3CG0.87037235
48INSRR0.84441996
49NME10.84269397
50CSF1R0.82486743
51OXSR10.82237420
52MYLK0.78840259
53LYN0.77700755
54FRK0.75865331
55CSNK1G20.73392529
56TAF10.71648999
57KIT0.71498420
58CSNK1A1L0.67306034
59ADRBK10.64458312
60CSNK1G10.63467491
61JAK30.62807956
62TYRO30.60948073
63MAP2K70.60671359
64PIM20.60307639
65PINK10.60139535
66PIK3CA0.59935662
67TBK10.56070173
68RPS6KA50.55620070
69TNK20.52550469
70BCR0.52521403
71GRK50.51261128
72IGF1R0.51188946
73OBSCN0.50013951
74CAMK2A0.49143850
75WNK30.49022159
76NEK10.45862917
77ERBB30.45732680
78MAPK130.44934429
79PDK20.44844938
80ATR0.44347212
81PHKG20.44078166
82PHKG10.44078166
83PRKCG0.43242545
84PRKCA0.42928409
85AURKA0.42862454
86FYN0.42750975
87PRKACA0.41190055
88STK390.38797473
89MAP2K60.37995182
90PIM10.37326818
91MAP3K50.37163771
92NME20.35737493
93EIF2AK20.35377696
94CSNK2A10.34305865
95PRKCE0.33079030
96CDK190.31069746
97CSNK2A20.30602955
98MKNK10.29595995
99MINK10.29572275
100DAPK30.28733865

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.47186502
2Primary immunodeficiency_Homo sapiens_hsa053404.20301602
3Oxidative phosphorylation_Homo sapiens_hsa001903.68603736
4Parkinsons disease_Homo sapiens_hsa050123.18491435
5Graft-versus-host disease_Homo sapiens_hsa053323.04867807
6Autoimmune thyroid disease_Homo sapiens_hsa053202.99837095
7Allograft rejection_Homo sapiens_hsa053302.90267480
8Ribosome_Homo sapiens_hsa030102.76117127
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.70199109
10Antigen processing and presentation_Homo sapiens_hsa046122.55390572
11RNA polymerase_Homo sapiens_hsa030202.43790313
12Type I diabetes mellitus_Homo sapiens_hsa049402.39068167
13Hematopoietic cell lineage_Homo sapiens_hsa046401.99367769
14Alzheimers disease_Homo sapiens_hsa050101.98521990
15Protein export_Homo sapiens_hsa030601.98252603
16Rheumatoid arthritis_Homo sapiens_hsa053231.89220442
17Huntingtons disease_Homo sapiens_hsa050161.86439743
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.82228433
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.74723510
20Asthma_Homo sapiens_hsa053101.69659906
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65120748
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.60262265
23Cardiac muscle contraction_Homo sapiens_hsa042601.58498277
24T cell receptor signaling pathway_Homo sapiens_hsa046601.52308327
25Phototransduction_Homo sapiens_hsa047441.36002367
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24893598
27Linoleic acid metabolism_Homo sapiens_hsa005911.19006816
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17351067
29Nitrogen metabolism_Homo sapiens_hsa009101.13215164
30Pyrimidine metabolism_Homo sapiens_hsa002401.08016059
31Viral myocarditis_Homo sapiens_hsa054161.05586908
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04403098
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99381134
34Propanoate metabolism_Homo sapiens_hsa006400.97559574
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97208537
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96945569
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92290635
38Caffeine metabolism_Homo sapiens_hsa002320.91913759
39RNA degradation_Homo sapiens_hsa030180.89557470
40SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84328943
41Homologous recombination_Homo sapiens_hsa034400.83784248
42Measles_Homo sapiens_hsa051620.82530294
43NF-kappa B signaling pathway_Homo sapiens_hsa040640.82048112
44Purine metabolism_Homo sapiens_hsa002300.81652383
45Peroxisome_Homo sapiens_hsa041460.81008483
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79174057
47Collecting duct acid secretion_Homo sapiens_hsa049660.77473963
48Fanconi anemia pathway_Homo sapiens_hsa034600.76592085
49One carbon pool by folate_Homo sapiens_hsa006700.74631201
50Sulfur metabolism_Homo sapiens_hsa009200.73891022
51Salmonella infection_Homo sapiens_hsa051320.72567896
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72021368
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69429337
54Spliceosome_Homo sapiens_hsa030400.66680085
55Folate biosynthesis_Homo sapiens_hsa007900.65513876
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65463763
57Butanoate metabolism_Homo sapiens_hsa006500.64095417
58Mismatch repair_Homo sapiens_hsa034300.61872378
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60723891
60Basal transcription factors_Homo sapiens_hsa030220.60679488
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60552219
62DNA replication_Homo sapiens_hsa030300.59765212
63Systemic lupus erythematosus_Homo sapiens_hsa053220.57555878
64Nucleotide excision repair_Homo sapiens_hsa034200.56167019
65Olfactory transduction_Homo sapiens_hsa047400.55265040
66Nicotine addiction_Homo sapiens_hsa050330.54704616
67Base excision repair_Homo sapiens_hsa034100.53510975
68Regulation of autophagy_Homo sapiens_hsa041400.52863968
69RNA transport_Homo sapiens_hsa030130.52429940
70Retinol metabolism_Homo sapiens_hsa008300.52255807
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49657477
72Fatty acid elongation_Homo sapiens_hsa000620.48959684
73Sulfur relay system_Homo sapiens_hsa041220.48729141
74Ether lipid metabolism_Homo sapiens_hsa005650.48172411
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.48166536
76Metabolic pathways_Homo sapiens_hsa011000.47402886
77Shigellosis_Homo sapiens_hsa051310.46536610
78Chemical carcinogenesis_Homo sapiens_hsa052040.45951109
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42549203
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42251459
81Epstein-Barr virus infection_Homo sapiens_hsa051690.41954306
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40208231
83Malaria_Homo sapiens_hsa051440.40162254
84Arachidonic acid metabolism_Homo sapiens_hsa005900.39147876
85Herpes simplex infection_Homo sapiens_hsa051680.38325935
86Staphylococcus aureus infection_Homo sapiens_hsa051500.38003537
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36982247
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.35841164
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31667153
90Tryptophan metabolism_Homo sapiens_hsa003800.30158093
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.27337758
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25429697
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.24888318
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22586760
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.21390059
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20147811
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19671472
98Steroid biosynthesis_Homo sapiens_hsa001000.19205180
99Taste transduction_Homo sapiens_hsa047420.17586177
100Tyrosine metabolism_Homo sapiens_hsa003500.16626543

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