RPS26P31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)8.46613112
2cytidine catabolic process (GO:0006216)8.46613112
3cytidine deamination (GO:0009972)8.46613112
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.21481325
5DNA deamination (GO:0045006)8.10673167
6pyrimidine ribonucleoside catabolic process (GO:0046133)7.46759294
7Arp2/3 complex-mediated actin nucleation (GO:0034314)4.97647423
8positive T cell selection (GO:0043368)4.82271949
9positive thymic T cell selection (GO:0045059)4.69438236
10negative T cell selection (GO:0043383)4.63896665
11actin nucleation (GO:0045010)4.59279687
12regulation of regulatory T cell differentiation (GO:0045589)4.58761889
13negative regulation of T cell apoptotic process (GO:0070233)4.49586233
14cellular response to interleukin-15 (GO:0071350)4.46365492
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.29880061
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.16461163
17positive regulation of natural killer cell mediated immunity (GO:0002717)4.14760191
18positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.11619681
19regulation of activation of Janus kinase activity (GO:0010533)4.10111385
20positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.01528314
21positive regulation of interleukin-8 secretion (GO:2000484)3.92436319
22positive regulation of calcium-mediated signaling (GO:0050850)3.91588004
23T cell migration (GO:0072678)3.91022061
24regulation of B cell receptor signaling pathway (GO:0050855)3.87311047
25pyrimidine nucleoside catabolic process (GO:0046135)3.86354610
26negative regulation by host of viral transcription (GO:0043922)3.81806452
27regulation of chronic inflammatory response (GO:0002676)3.80982671
28negative regulation of viral genome replication (GO:0045071)3.80810218
29sequestering of actin monomers (GO:0042989)3.80274826
30cytolysis (GO:0019835)3.76095673
31regulation of leukocyte mediated cytotoxicity (GO:0001910)3.71938165
32regulation of T cell receptor signaling pathway (GO:0050856)3.71629249
33negative thymic T cell selection (GO:0045060)3.71121811
34thymic T cell selection (GO:0045061)3.71058895
35eosinophil chemotaxis (GO:0048245)3.70239593
36positive regulation of T cell mediated cytotoxicity (GO:0001916)3.68078602
37positive regulation of gamma-delta T cell activation (GO:0046645)3.67451484
38regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.66727512
39regulation of natural killer cell mediated immunity (GO:0002715)3.66727512
40regulation of gamma-delta T cell differentiation (GO:0045586)3.54060082
41positive regulation of cell killing (GO:0031343)3.52666474
42positive regulation of defense response to virus by host (GO:0002230)3.48442754
43regulation of T cell mediated cytotoxicity (GO:0001914)3.48130609
44positive regulation of tolerance induction (GO:0002645)3.47916023
45mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.44890718
46regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.42056518
47T cell receptor signaling pathway (GO:0050852)3.40317548
48eosinophil migration (GO:0072677)3.36666278
49response to interleukin-15 (GO:0070672)3.36097945
50T cell selection (GO:0045058)3.34718408
51negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.33467512
52negative regulation of lymphocyte apoptotic process (GO:0070229)3.33383985
53regulation of cell killing (GO:0031341)3.30342948
54regulation of interleukin-8 secretion (GO:2000482)3.29679342
55energy coupled proton transport, down electrochemical gradient (GO:0015985)3.27768499
56ATP synthesis coupled proton transport (GO:0015986)3.27768499
57response to interferon-beta (GO:0035456)3.27210143
58regulation of T cell tolerance induction (GO:0002664)3.22469775
59iron-sulfur cluster assembly (GO:0016226)3.18473064
60metallo-sulfur cluster assembly (GO:0031163)3.18473064
61positive regulation of B cell differentiation (GO:0045579)3.17134983
62regulation of isotype switching to IgG isotypes (GO:0048302)3.15576906
63macrophage chemotaxis (GO:0048246)3.14464416
64regulation of T cell apoptotic process (GO:0070232)3.13475811
65positive regulation of alpha-beta T cell proliferation (GO:0046641)3.08637292
66T cell costimulation (GO:0031295)3.08612917
67lymphocyte costimulation (GO:0031294)3.06883591
68mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.06562145
69regulation of T cell chemotaxis (GO:0010819)3.06355688
70positive regulation of T cell chemotaxis (GO:0010820)3.06355688
71regulation of B cell differentiation (GO:0045577)2.96253928
72negative regulation of T cell receptor signaling pathway (GO:0050860)2.94476056
73mast cell activation (GO:0045576)2.92630181
74regulation of gamma-delta T cell activation (GO:0046643)2.89819635
75respiratory electron transport chain (GO:0022904)2.87812787
76regulation of calcium-mediated signaling (GO:0050848)2.87790398
77regulation of lymphocyte chemotaxis (GO:1901623)2.86779601
78antigen receptor-mediated signaling pathway (GO:0050851)2.86063023
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.85669837
80electron transport chain (GO:0022900)2.85456552
81regulation of alpha-beta T cell proliferation (GO:0046640)2.84832297
82regulation of viral genome replication (GO:0045069)2.83756203
83regulation of cellular amino acid metabolic process (GO:0006521)2.81804512
84negative regulation of cell killing (GO:0031342)2.79422879
85negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.79422879
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.77555135
87ribosomal small subunit assembly (GO:0000028)2.76156632
88platelet dense granule organization (GO:0060155)2.75128301
89positive regulation of uterine smooth muscle contraction (GO:0070474)2.73810558
90positive regulation of prostaglandin secretion (GO:0032308)2.72093479
91positive regulation of lymphocyte migration (GO:2000403)2.70256455
92positive regulation of monocyte chemotaxis (GO:0090026)2.68547829
93negative regulation of stress fiber assembly (GO:0051497)2.66943611
94regulation of tolerance induction (GO:0002643)2.66656950
95cellular defense response (GO:0006968)2.65907341
96positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.64265707
97regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.62971123
98positive regulation of T cell apoptotic process (GO:0070234)2.61504645
99lymphocyte migration (GO:0072676)2.60951413
100DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.60477139

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.41354087
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.20707461
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.06343616
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.91886043
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.42173348
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.30422821
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.26013933
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.01402958
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.74706160
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.73989283
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.62352783
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.61107267
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.58399591
14MYB_26560356_Chip-Seq_TH2_Human2.50754335
15VDR_22108803_ChIP-Seq_LS180_Human2.22278114
16RUNX_20019798_ChIP-Seq_JUKART_Human2.21109514
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.18637712
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.03627514
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00623475
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.97622914
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96274438
22VDR_23849224_ChIP-Seq_CD4+_Human1.95522715
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95312028
24GATA3_27048872_Chip-Seq_THYMUS_Human1.94045336
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.92992912
26GATA3_26560356_Chip-Seq_TH2_Human1.91827382
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84063085
28IGF1R_20145208_ChIP-Seq_DFB_Human1.82511414
29ZNF274_21170338_ChIP-Seq_K562_Hela1.74062287
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71591752
31MYB_26560356_Chip-Seq_TH1_Human1.62077760
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.61265345
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59123233
34EZH2_22144423_ChIP-Seq_EOC_Human1.55120931
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53038524
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.42988329
37PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.38837442
38UTX_26944678_Chip-Seq_JUKART_Human1.38323463
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.37214424
40FOXP3_21729870_ChIP-Seq_TREG_Human1.36993837
41TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.35230620
42RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.34924929
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.33992178
44AR_20517297_ChIP-Seq_VCAP_Human1.31498280
45EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.29732858
46PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.29083238
47BCL6_27268052_Chip-Seq_Bcells_Human1.25752411
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25702739
49TP53_22573176_ChIP-Seq_HFKS_Human1.24424283
50HTT_18923047_ChIP-ChIP_STHdh_Human1.23481525
51NANOG_20526341_ChIP-Seq_ESCs_Human1.23289771
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20607455
53MAF_26560356_Chip-Seq_TH2_Human1.19649997
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18859974
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17228156
56NCOR_22424771_ChIP-Seq_293T_Human1.15877886
57TAF2_19829295_ChIP-Seq_ESCs_Human1.15665959
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15445166
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.15445166
60MYC_18940864_ChIP-ChIP_HL60_Human1.14553701
61GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13223160
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11868360
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11236652
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09524883
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07954037
66GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07794047
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.06586666
68CTCF_20526341_ChIP-Seq_ESCs_Human1.05547154
69MAF_26560356_Chip-Seq_TH1_Human1.05008808
70RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04729431
71MYC_19829295_ChIP-Seq_ESCs_Human1.03556163
72P300_27268052_Chip-Seq_Bcells_Human1.03459910
73FOXH1_21741376_ChIP-Seq_EPCs_Human1.03016417
74ELK1_19687146_ChIP-ChIP_HELA_Human1.02075803
75FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00169499
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00029776
77CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99872085
78ER_23166858_ChIP-Seq_MCF-7_Human0.99698904
79YY1_22570637_ChIP-Seq_MALME-3M_Human0.98080735
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97468823
81SPI1_23547873_ChIP-Seq_NB4_Human0.97269591
82GATA6_21074721_ChIP-Seq_CACO-2_Human0.96912891
83SOX2_19829295_ChIP-Seq_ESCs_Human0.96891682
84NANOG_19829295_ChIP-Seq_ESCs_Human0.96891682
85EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96513485
86RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96026615
87NFE2_27457419_Chip-Seq_LIVER_Mouse0.95239242
88ERA_21632823_ChIP-Seq_H3396_Human0.94981206
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94691947
90FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94360507
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92506821
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92151323
93GATA3_26560356_Chip-Seq_TH1_Human0.90048715
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89762212
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89444997
96ERG_20517297_ChIP-Seq_VCAP_Human0.89393792
97GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.87195865
98FOXH1_21741376_ChIP-Seq_ESCs_Human0.86263418
99RBPJ_21746931_ChIP-Seq_IB4_Human0.85508285
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84184765

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.29600403
2MP0001835_abnormal_antigen_presentation3.34835509
3MP0003763_abnormal_thymus_physiology3.30010383
4MP0009785_altered_susceptibility_to3.19552763
5MP0009333_abnormal_splenocyte_physiolog2.81898075
6MP0005000_abnormal_immune_tolerance2.67901757
7MP0001800_abnormal_humoral_immune2.50548404
8MP0002166_altered_tumor_susceptibility2.46393768
9MP0002148_abnormal_hypersensitivity_rea2.35039993
10MP0002723_abnormal_immune_serum2.31164677
11MP0002420_abnormal_adaptive_immunity2.28785588
12MP0000685_abnormal_immune_system2.27191799
13MP0005025_abnormal_response_to2.27133958
14MP0001819_abnormal_immune_cell2.22797640
15MP0006082_CNS_inflammation2.22139804
16MP0001873_stomach_inflammation2.14677899
17MP0003866_abnormal_defecation2.14454512
18MP0005387_immune_system_phenotype2.08528050
19MP0001790_abnormal_immune_system2.08528050
20MP0006072_abnormal_retinal_apoptosis1.91427541
21MP0002452_abnormal_antigen_presenting1.90183997
22MP0002006_tumorigenesis1.88999785
23MP0002933_joint_inflammation1.79501181
24MP0002405_respiratory_system_inflammati1.75164457
25MP0000716_abnormal_immune_system1.73685188
26MP0002138_abnormal_hepatobiliary_system1.72938647
27MP0010155_abnormal_intestine_physiology1.69565208
28MP0002398_abnormal_bone_marrow1.67530960
29MP0003436_decreased_susceptibility_to1.66919548
30MP0004147_increased_porphyrin_level1.65339966
31MP0000372_irregular_coat_pigmentation1.61074281
32MP0005645_abnormal_hypothalamus_physiol1.59529513
33MP0001919_abnormal_reproductive_system1.53213168
34MP0008872_abnormal_physiological_respon1.52161698
35MP0001845_abnormal_inflammatory_respons1.52052266
36MP0000703_abnormal_thymus_morphology1.51376828
37MP0004145_abnormal_muscle_electrophysio1.43605486
38MP0000689_abnormal_spleen_morphology1.42749476
39MP0003646_muscle_fatigue1.40469300
40MP0002722_abnormal_immune_system1.40212995
41MP0002419_abnormal_innate_immunity1.39910845
42MP0005075_abnormal_melanosome_morpholog1.35928780
43MP0005377_hearing/vestibular/ear_phenot1.35811498
44MP0003878_abnormal_ear_physiology1.35811498
45MP0001968_abnormal_touch/_nociception1.34600784
46MP0001905_abnormal_dopamine_level1.30777056
47MP0005551_abnormal_eye_electrophysiolog1.29816477
48MP0001853_heart_inflammation1.29381356
49MP0002102_abnormal_ear_morphology1.28392044
50MP0008875_abnormal_xenobiotic_pharmacok1.28288948
51MP0002429_abnormal_blood_cell1.28027221
52MP0003195_calcinosis1.26342362
53MP0005646_abnormal_pituitary_gland1.25694632
54MP0003724_increased_susceptibility_to1.24441144
55MP0005360_urolithiasis1.24212581
56MP0005389_reproductive_system_phenotype1.20011060
57MP0004947_skin_inflammation1.18350659
58MP0002277_abnormal_respiratory_mucosa1.14814840
59MP0008469_abnormal_protein_level1.12562408
60MP0002876_abnormal_thyroid_physiology1.12303580
61MP0002837_dystrophic_cardiac_calcinosis1.12159579
62MP0005253_abnormal_eye_physiology1.11764908
63MP0002736_abnormal_nociception_after1.11460452
64MP0002163_abnormal_gland_morphology1.11227055
65MP0003011_delayed_dark_adaptation1.08741914
66MP0003786_premature_aging1.06362497
67MP0002693_abnormal_pancreas_physiology1.04540770
68MP0009764_decreased_sensitivity_to1.03517140
69MP0003045_fibrosis0.98063826
70MP0001986_abnormal_taste_sensitivity0.97065450
71MP0003806_abnormal_nucleotide_metabolis0.96511424
72MP0003448_altered_tumor_morphology0.96109821
73MP0009379_abnormal_foot_pigmentation0.92434492
74MP0004885_abnormal_endolymph0.91584019
75MP0005464_abnormal_platelet_physiology0.91065163
76MP0005410_abnormal_fertilization0.90549078
77MP0009763_increased_sensitivity_to0.90089262
78MP0001765_abnormal_ion_homeostasis0.87818806
79MP0003880_abnormal_central_pattern0.87244291
80MP0001501_abnormal_sleep_pattern0.86537024
81MP0001533_abnormal_skeleton_physiology0.86240903
82MP0008877_abnormal_DNA_methylation0.79931182
83MP0010386_abnormal_urinary_bladder0.79095368
84MP0005636_abnormal_mineral_homeostasis0.78634890
85MP0009643_abnormal_urine_homeostasis0.77844687
86MP0003137_abnormal_impulse_conducting0.77463446
87MP0005379_endocrine/exocrine_gland_phen0.74633858
88MP0002095_abnormal_skin_pigmentation0.73306483
89MP0006036_abnormal_mitochondrial_physio0.71336311
90MP0005083_abnormal_biliary_tract0.70918811
91MP0002638_abnormal_pupillary_reflex0.69590824
92MP0009745_abnormal_behavioral_response0.68550207
93MP0002019_abnormal_tumor_incidence0.67458916
94MP0001542_abnormal_bone_strength0.64938445
95MP0005166_decreased_susceptibility_to0.64690679
96MP0001764_abnormal_homeostasis0.64298888
97MP0006276_abnormal_autonomic_nervous0.63786710
98MP0005084_abnormal_gallbladder_morpholo0.63671719
99MP0002136_abnormal_kidney_physiology0.63257344
100MP0000465_gastrointestinal_hemorrhage0.62468474

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.37346056
2Abnormality of T cell number (HP:0011839)5.18410896
3IgG deficiency (HP:0004315)4.96614639
4Aplastic anemia (HP:0001915)4.88067331
5Severe combined immunodeficiency (HP:0004430)4.65235254
6Elevated erythrocyte sedimentation rate (HP:0003565)4.32769359
7Hypoproteinemia (HP:0003075)4.06957897
8Increased IgM level (HP:0003496)3.86610918
9Abnormality of T cells (HP:0002843)3.83380560
10Autoimmune hemolytic anemia (HP:0001890)3.81532426
11Thyroiditis (HP:0100646)3.78152264
12Combined immunodeficiency (HP:0005387)3.62950143
13Mitochondrial inheritance (HP:0001427)3.46094547
14Abnormality of eosinophils (HP:0001879)3.44826048
15Absent rod-and cone-mediated responses on ERG (HP:0007688)3.38904073
16Congenital stationary night blindness (HP:0007642)3.29981801
17Abnormality of B cell number (HP:0010975)3.29465557
18Acute necrotizing encephalopathy (HP:0006965)3.12480275
19Abnormality of the prostate (HP:0008775)3.06981893
20Chronic diarrhea (HP:0002028)3.04785792
21Increased intramyocellular lipid droplets (HP:0012240)3.03886007
22Renal Fanconi syndrome (HP:0001994)2.98023158
23Stomatitis (HP:0010280)2.93797408
24Abnormal mitochondria in muscle tissue (HP:0008316)2.93375033
253-Methylglutaconic aciduria (HP:0003535)2.93038983
26Increased CSF lactate (HP:0002490)2.87494721
27Increased hepatocellular lipid droplets (HP:0006565)2.83270796
28B lymphocytopenia (HP:0010976)2.81383622
29Eosinophilia (HP:0001880)2.78654576
30Hepatocellular necrosis (HP:0001404)2.73902909
31Abnormal rod and cone electroretinograms (HP:0008323)2.68657675
32Pancreatic cysts (HP:0001737)2.68351902
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.67180529
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.67180529
35Encephalitis (HP:0002383)2.67133788
36Progressive macrocephaly (HP:0004481)2.59952845
37Acute encephalopathy (HP:0006846)2.56893714
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.55363834
39Attenuation of retinal blood vessels (HP:0007843)2.54223764
40Pancytopenia (HP:0001876)2.54121813
41Increased muscle lipid content (HP:0009058)2.48010108
42Lipid accumulation in hepatocytes (HP:0006561)2.47578192
43Hepatic necrosis (HP:0002605)2.46941532
44Leukocytosis (HP:0001974)2.43084118
45Chronic mucocutaneous candidiasis (HP:0002728)2.42649830
46Recurrent cutaneous fungal infections (HP:0011370)2.42649830
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.41092684
48Abolished electroretinogram (ERG) (HP:0000550)2.36863012
49Abnormality of T cell physiology (HP:0011840)2.36500898
50IgM deficiency (HP:0002850)2.30681858
51Cerebral edema (HP:0002181)2.29024663
52Hypoalbuminemia (HP:0003073)2.27576611
53Abnormal albumin level (HP:0012116)2.27576611
54Generalized aminoaciduria (HP:0002909)2.21365586
55Lymphopenia (HP:0001888)2.20468444
56Autoimmune thrombocytopenia (HP:0001973)2.20071618
57Panhypogammaglobulinemia (HP:0003139)2.19710068
58Pancreatic fibrosis (HP:0100732)2.18119454
59Recurrent bronchitis (HP:0002837)2.15835312
60Optic disc pallor (HP:0000543)2.15674450
61Amyotrophic lateral sclerosis (HP:0007354)2.15126513
62Pustule (HP:0200039)2.13390772
63Granulocytopenia (HP:0001913)2.12718831
64Abnormality of cells of the lymphoid lineage (HP:0012140)2.11294395
65Decreased central vision (HP:0007663)2.07196327
66Renal cortical cysts (HP:0000803)2.06755488
67Hypoplasia of the thymus (HP:0000778)2.06422905
68Lactic acidosis (HP:0003128)2.05937715
69True hermaphroditism (HP:0010459)2.05436643
70Meningitis (HP:0001287)2.03907344
71Hypergammaglobulinemia (HP:0010702)1.99927373
72Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98727934
73Pulmonary infiltrates (HP:0002113)1.97293003
74Recurrent fungal infections (HP:0002841)1.95508056
75Agammaglobulinemia (HP:0004432)1.94744102
76Increased serum lactate (HP:0002151)1.93295143
77Myositis (HP:0100614)1.92892880
78Abnormality of macrophages (HP:0004311)1.92658993
79Joint swelling (HP:0001386)1.91848235
80Abnormality of the renal cortex (HP:0011035)1.91509838
81Lymphoma (HP:0002665)1.90797259
82Exertional dyspnea (HP:0002875)1.89532266
83Aplasia/hypoplasia of the uterus (HP:0008684)1.89514405
84Type 2 muscle fiber atrophy (HP:0003554)1.89454467
85Abnormal drinking behavior (HP:0030082)1.88695106
86Polydipsia (HP:0001959)1.88695106
87Congenital, generalized hypertrichosis (HP:0004540)1.86511903
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.85312585
89Abnormality of midbrain morphology (HP:0002418)1.85208438
90Molar tooth sign on MRI (HP:0002419)1.85208438
91Lethargy (HP:0001254)1.83084332
92Constricted visual fields (HP:0001133)1.82524374
93Stomach cancer (HP:0012126)1.82336401
94Vasculitis (HP:0002633)1.81974250
95Obstructive lung disease (HP:0006536)1.79311263
96Chronic obstructive pulmonary disease (HP:0006510)1.79311263
97Gangrene (HP:0100758)1.78897595
98Oral leukoplakia (HP:0002745)1.78459749
99Cerebral palsy (HP:0100021)1.78190075
100Ketosis (HP:0001946)1.76978602

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.66260510
2KDR5.43172722
3TESK25.02770298
4BCKDK3.11602889
5TAOK32.56017964
6ADRBK22.43630771
7MAP4K12.42788545
8ITK2.40706482
9TLK12.38288921
10ZAK2.28872900
11VRK22.13972401
12MAP4K22.12150395
13LIMK12.02244632
14FES2.01408294
15TESK11.90174317
16GRK61.82253381
17SCYL21.80524632
18MUSK1.54628080
19GRK11.52119525
20FRK1.48709021
21SYK1.48432292
22TEC1.47987883
23ZAP701.33534574
24VRK11.33495290
25MAP3K121.31321697
26MAP3K111.25299846
27PASK1.23688583
28MAPKAPK31.22626971
29PRKCQ1.22220132
30LCK1.21397256
31CSK1.18518913
32BTK1.17483493
33NUAK11.17085935
34IKBKE1.12244785
35CAMKK21.10407049
36GRK71.08036211
37MST41.07293991
38KIT1.06295875
39WNK41.05463935
40IKBKB0.98390265
41PINK10.98200404
42BUB10.97442534
43CSF1R0.94641058
44LYN0.93441267
45TNK20.87430496
46BMPR1B0.76854057
47MYLK0.75059042
48STK160.72197977
49DAPK10.72111146
50INSRR0.72095055
51OXSR10.69493471
52TBK10.67549840
53ERBB30.64895121
54JAK30.63313530
55TIE10.61962799
56CAMKK10.61649590
57RPS6KA50.60665699
58PIM10.60625148
59EIF2AK30.60329948
60ADRBK10.56551519
61IGF1R0.55462590
62CDK190.52688291
63MAP2K60.50698833
64OBSCN0.50263065
65MATK0.46458637
66FYN0.46112434
67MAP2K70.45972052
68HCK0.43491728
69BMPR20.42755902
70PIM20.42591935
71FLT30.42546999
72GRK50.42052599
73CSNK1G30.41768122
74BLK0.41136562
75NME10.40813155
76DAPK20.40127406
77PRKCA0.38833203
78RIPK40.37688696
79ROCK10.36408718
80MAPK130.35851672
81PIK3CA0.35448611
82PIK3CG0.34597687
83WNK30.34096750
84MAPKAPK50.32804196
85PRKACA0.32511423
86INSR0.31569608
87RPS6KA40.29634876
88ABL10.28250440
89PHKG10.28055970
90PHKG20.28055970
91STK390.27039508
92TRPM70.26350961
93AURKA0.24746097
94CAMK2A0.24652540
95MAP3K50.24167833
96PRKCH0.21163853
97CLK10.20858533
98CSNK1G10.19878680
99JAK10.19525543
100CSNK1A1L0.19077053

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.60852724
2Proteasome_Homo sapiens_hsa030503.96729003
3Oxidative phosphorylation_Homo sapiens_hsa001903.12306249
4Graft-versus-host disease_Homo sapiens_hsa053323.10201336
5Autoimmune thyroid disease_Homo sapiens_hsa053202.98879687
6Allograft rejection_Homo sapiens_hsa053302.82859062
7Antigen processing and presentation_Homo sapiens_hsa046122.78351344
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.61629533
9Parkinsons disease_Homo sapiens_hsa050122.59217163
10Hematopoietic cell lineage_Homo sapiens_hsa046402.44546905
11Type I diabetes mellitus_Homo sapiens_hsa049402.30641917
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.19787560
13T cell receptor signaling pathway_Homo sapiens_hsa046602.14286038
14RNA polymerase_Homo sapiens_hsa030202.08846579
15Ribosome_Homo sapiens_hsa030102.01662395
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.90291172
17Alzheimers disease_Homo sapiens_hsa050101.73881099
18Rheumatoid arthritis_Homo sapiens_hsa053231.69419465
19Phototransduction_Homo sapiens_hsa047441.65447518
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.58123540
21Asthma_Homo sapiens_hsa053101.57911621
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54302346
23Protein export_Homo sapiens_hsa030601.49532123
24Huntingtons disease_Homo sapiens_hsa050161.45267085
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.43033338
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.39329842
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35261473
28Nitrogen metabolism_Homo sapiens_hsa009101.34620407
29Cardiac muscle contraction_Homo sapiens_hsa042601.33484935
30Linoleic acid metabolism_Homo sapiens_hsa005911.33128631
31Caffeine metabolism_Homo sapiens_hsa002321.20376953
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18406769
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16179239
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15810222
35Measles_Homo sapiens_hsa051621.10301651
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07828678
37Viral myocarditis_Homo sapiens_hsa054161.05444598
38Peroxisome_Homo sapiens_hsa041460.98606374
39Malaria_Homo sapiens_hsa051440.90454043
40Homologous recombination_Homo sapiens_hsa034400.84925208
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80606966
42Primary bile acid biosynthesis_Homo sapiens_hsa001200.79435786
43Shigellosis_Homo sapiens_hsa051310.78051228
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76178673
45Pyrimidine metabolism_Homo sapiens_hsa002400.76090510
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75233254
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75036962
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74816598
49Olfactory transduction_Homo sapiens_hsa047400.74445476
50Salmonella infection_Homo sapiens_hsa051320.73056617
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71799604
52Purine metabolism_Homo sapiens_hsa002300.68316338
53RNA degradation_Homo sapiens_hsa030180.67068507
54Chemical carcinogenesis_Homo sapiens_hsa052040.66604295
55Retinol metabolism_Homo sapiens_hsa008300.63242675
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.62346342
57Propanoate metabolism_Homo sapiens_hsa006400.59845271
58Systemic lupus erythematosus_Homo sapiens_hsa053220.58638890
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.58288889
60Butanoate metabolism_Homo sapiens_hsa006500.57348431
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57316273
62Regulation of autophagy_Homo sapiens_hsa041400.54666734
63Collecting duct acid secretion_Homo sapiens_hsa049660.53838627
64Tryptophan metabolism_Homo sapiens_hsa003800.53442754
65Fanconi anemia pathway_Homo sapiens_hsa034600.52652119
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51623724
67Arachidonic acid metabolism_Homo sapiens_hsa005900.50487659
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49329086
69Staphylococcus aureus infection_Homo sapiens_hsa051500.48725746
70Sulfur metabolism_Homo sapiens_hsa009200.47682706
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44887176
72Ether lipid metabolism_Homo sapiens_hsa005650.43042687
73One carbon pool by folate_Homo sapiens_hsa006700.42381374
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41874771
75Basal transcription factors_Homo sapiens_hsa030220.39911732
76Herpes simplex infection_Homo sapiens_hsa051680.39768067
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39305298
78Nicotine addiction_Homo sapiens_hsa050330.38180554
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37254898
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.37241607
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.36634085
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35528309
83Taste transduction_Homo sapiens_hsa047420.34899381
84Metabolic pathways_Homo sapiens_hsa011000.34581017
85Salivary secretion_Homo sapiens_hsa049700.34342126
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32675122
87Morphine addiction_Homo sapiens_hsa050320.29154031
88Chemokine signaling pathway_Homo sapiens_hsa040620.28858769
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27886932
90Epstein-Barr virus infection_Homo sapiens_hsa051690.26902752
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25063373
92Nucleotide excision repair_Homo sapiens_hsa034200.24419670
93Fat digestion and absorption_Homo sapiens_hsa049750.22757469
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22382125
95Leishmaniasis_Homo sapiens_hsa051400.19526075
96ABC transporters_Homo sapiens_hsa020100.17994835
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17246011
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16345116
99Legionellosis_Homo sapiens_hsa051340.16333152
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.15847654

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