RPS26P34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)9.25234937
2cytidine catabolic process (GO:0006216)9.25234937
3cytidine deamination (GO:0009972)9.25234937
4pyrimidine ribonucleoside catabolic process (GO:0046133)8.16236188
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.01443330
6DNA deamination (GO:0045006)7.63814576
7Arp2/3 complex-mediated actin nucleation (GO:0034314)6.03307459
8T cell migration (GO:0072678)5.70523257
9positive T cell selection (GO:0043368)5.65673390
10positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.54495635
11actin nucleation (GO:0045010)5.49940343
12positive regulation of natural killer cell mediated immunity (GO:0002717)5.44661112
13cytolysis (GO:0019835)5.38032645
14eosinophil chemotaxis (GO:0048245)5.33339882
15positive thymic T cell selection (GO:0045059)5.32334877
16negative regulation by host of viral transcription (GO:0043922)4.99571965
17regulation of activation of Janus kinase activity (GO:0010533)4.92018287
18positive regulation of calcium-mediated signaling (GO:0050850)4.89467785
19negative regulation of T cell apoptotic process (GO:0070233)4.87888589
20eosinophil migration (GO:0072677)4.84404566
21regulation of natural killer cell mediated immunity (GO:0002715)4.70692239
22regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.70692239
23sequestering of actin monomers (GO:0042989)4.60504355
24positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.56646225
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.52576167
26positive regulation of interleukin-8 secretion (GO:2000484)4.43583288
27regulation of B cell receptor signaling pathway (GO:0050855)4.40256248
28regulation of chronic inflammatory response (GO:0002676)4.39100535
29negative T cell selection (GO:0043383)4.18520433
30cellular response to interleukin-15 (GO:0071350)4.16076970
31regulation of leukocyte mediated cytotoxicity (GO:0001910)4.14590656
32pyrimidine nucleoside catabolic process (GO:0046135)4.08254336
33positive regulation of cell killing (GO:0031343)4.03984406
34negative regulation of viral genome replication (GO:0045071)3.97293635
35regulation of regulatory T cell differentiation (GO:0045589)3.94218659
36macrophage chemotaxis (GO:0048246)3.88816606
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.87821914
38thymic T cell selection (GO:0045061)3.87460265
39regulation of lymphocyte chemotaxis (GO:1901623)3.85838771
40positive regulation of gamma-delta T cell activation (GO:0046645)3.80266622
41positive regulation of monocyte chemotaxis (GO:0090026)3.79628399
42positive regulation of tolerance induction (GO:0002645)3.75706682
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.75079000
44regulation of cell killing (GO:0031341)3.71767009
45regulation of T cell tolerance induction (GO:0002664)3.65246577
46T cell receptor signaling pathway (GO:0050852)3.62293533
47T cell selection (GO:0045058)3.60914686
48negative regulation of stress fiber assembly (GO:0051497)3.59249472
49regulation of calcium-mediated signaling (GO:0050848)3.57382952
50lymphocyte costimulation (GO:0031294)3.55786296
51iron-sulfur cluster assembly (GO:0016226)3.52100232
52metallo-sulfur cluster assembly (GO:0031163)3.52100232
53T cell costimulation (GO:0031295)3.51302364
54positive regulation of T cell mediated cytotoxicity (GO:0001916)3.46949409
55regulation of T cell chemotaxis (GO:0010819)3.44443396
56positive regulation of T cell chemotaxis (GO:0010820)3.44443396
57regulation of interleukin-8 secretion (GO:2000482)3.35928564
58positive regulation of T cell apoptotic process (GO:0070234)3.33914029
59regulation of T cell apoptotic process (GO:0070232)3.33561325
60lymphocyte chemotaxis (GO:0048247)3.32893343
61ATP synthesis coupled proton transport (GO:0015986)3.31199144
62energy coupled proton transport, down electrochemical gradient (GO:0015985)3.31199144
63negative regulation of lymphocyte apoptotic process (GO:0070229)3.30301115
64negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.28621778
65regulation of T cell receptor signaling pathway (GO:0050856)3.28158701
66regulation of T cell mediated cytotoxicity (GO:0001914)3.27739742
67positive regulation of lymphocyte migration (GO:2000403)3.21996438
68positive regulation of uterine smooth muscle contraction (GO:0070474)3.21933431
69regulation of gamma-delta T cell differentiation (GO:0045586)3.20710584
70response to interleukin-15 (GO:0070672)3.19321389
71mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.18665017
72lymphocyte migration (GO:0072676)3.17703977
73respiratory electron transport chain (GO:0022904)3.15773712
74positive regulation of B cell differentiation (GO:0045579)3.12431201
75electron transport chain (GO:0022900)3.10859578
76negative regulation of execution phase of apoptosis (GO:1900118)3.10309910
77respiratory burst (GO:0045730)3.09481877
78regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.08913362
79antigen receptor-mediated signaling pathway (GO:0050851)3.08122570
80monocyte chemotaxis (GO:0002548)3.07092502
81negative regulation of viral transcription (GO:0032897)3.07083311
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.06131719
83positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.05841646
84cellular defense response (GO:0006968)3.05412214
85positive regulation of interleukin-4 production (GO:0032753)3.03383123
86negative regulation of oxidoreductase activity (GO:0051354)3.02970380
87regulation of cellular amino acid metabolic process (GO:0006521)3.00978235
88regulation of tolerance induction (GO:0002643)2.99982935
89positive regulation of translational initiation (GO:0045948)2.98325959
90antigen processing and presentation via MHC class Ib (GO:0002475)2.92882720
91response to interferon-beta (GO:0035456)2.91464860
92negative regulation of actin filament bundle assembly (GO:0032232)2.91451918
93negative thymic T cell selection (GO:0045060)2.86607261
94regulation of B cell differentiation (GO:0045577)2.84882956
95positive regulation of defense response to virus by host (GO:0002230)2.84708494
96T cell mediated immunity (GO:0002456)2.83160100
97antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.82890212
98regulation of chemokine-mediated signaling pathway (GO:0070099)2.82650603
99regulation of viral genome replication (GO:0045069)2.82538222
100protein neddylation (GO:0045116)2.82203678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.06376611
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.74271589
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.26708834
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.85160054
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.41031546
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.17603667
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.02041176
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.83530903
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.79787166
10MYB_26560356_Chip-Seq_TH2_Human2.55804981
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.53988127
12EZH2_22144423_ChIP-Seq_EOC_Human2.43717019
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.30879003
14VDR_22108803_ChIP-Seq_LS180_Human2.25168105
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17425984
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.14001062
17GATA3_27048872_Chip-Seq_THYMUS_Human1.98305905
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.97366093
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.90464463
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.89562233
21RUNX_20019798_ChIP-Seq_JUKART_Human1.82070213
22HTT_18923047_ChIP-ChIP_STHdh_Human1.81188725
23UTX_26944678_Chip-Seq_JUKART_Human1.75093579
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73375501
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.70344561
26GATA3_26560356_Chip-Seq_TH2_Human1.70161516
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69774454
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.65999767
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.63131935
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62642493
31MYB_26560356_Chip-Seq_TH1_Human1.61666911
32RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.59909162
33IGF1R_20145208_ChIP-Seq_DFB_Human1.54400638
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.52887769
35VDR_23849224_ChIP-Seq_CD4+_Human1.52380435
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43628383
37EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.36994668
38MAF_26560356_Chip-Seq_TH2_Human1.36346203
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34351584
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.30638858
41TAF2_19829295_ChIP-Seq_ESCs_Human1.29921741
42PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.29616209
43TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.27702135
44NANOG_20526341_ChIP-Seq_ESCs_Human1.26460440
45PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.26225861
46MAF_26560356_Chip-Seq_TH1_Human1.21857787
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21773254
48TP53_22573176_ChIP-Seq_HFKS_Human1.21519952
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19759125
50BCL6_27268052_Chip-Seq_Bcells_Human1.17751548
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17318855
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16283775
53ETS1_20019798_ChIP-Seq_JURKAT_Human1.11756787
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10320100
55FOXA1_25329375_ChIP-Seq_VCAP_Human1.10320100
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09349035
57AR_20517297_ChIP-Seq_VCAP_Human1.07504498
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.07241387
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05629839
60MYC_19829295_ChIP-Seq_ESCs_Human1.05453380
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04514052
62GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.02797211
63NCOR_22424771_ChIP-Seq_293T_Human1.02363927
64EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01721837
65GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99973684
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99700586
67GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99558624
68ERG_20517297_ChIP-Seq_VCAP_Human0.99274426
69CTCF_20526341_ChIP-Seq_ESCs_Human0.98108675
70YY1_22570637_ChIP-Seq_MALME-3M_Human0.97274314
71CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97140360
72ELF1_20517297_ChIP-Seq_JURKAT_Human0.96947165
73AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96164292
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95676234
75CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94437991
76FOXH1_21741376_ChIP-Seq_EPCs_Human0.94202631
77ZNF274_21170338_ChIP-Seq_K562_Hela0.93902383
78ERA_21632823_ChIP-Seq_H3396_Human0.93708512
79P300_27268052_Chip-Seq_Bcells_Human0.92969414
80GATA6_21074721_ChIP-Seq_CACO-2_Human0.90956005
81FOXP3_21729870_ChIP-Seq_TREG_Human0.89843542
82YY1_21170310_ChIP-Seq_MESCs_Mouse0.89316589
83ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89279822
84SA1_27219007_Chip-Seq_Bcells_Human0.89268410
85TAF15_26573619_Chip-Seq_HEK293_Human0.89263948
86NANOG_19829295_ChIP-Seq_ESCs_Human0.88290261
87SOX2_19829295_ChIP-Seq_ESCs_Human0.88290261
88BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87881711
89OCT4_20526341_ChIP-Seq_ESCs_Human0.87579635
90EGR1_23403033_ChIP-Seq_LIVER_Mouse0.87226416
91BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.87055030
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86454816
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85205731
94SPI1_23547873_ChIP-Seq_NB4_Human0.84816333
95CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84583423
96TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.84069091
97ER_23166858_ChIP-Seq_MCF-7_Human0.83749167
98BCAT_22108803_ChIP-Seq_LS180_Human0.83384603
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83303975
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82567741

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to7.16126153
2MP0009785_altered_susceptibility_to3.89568050
3MP0006082_CNS_inflammation3.18493647
4MP0003763_abnormal_thymus_physiology3.08362369
5MP0001835_abnormal_antigen_presentation2.94658951
6MP0009333_abnormal_splenocyte_physiolog2.87783307
7MP0002166_altered_tumor_susceptibility2.70501975
8MP0003866_abnormal_defecation2.57713130
9MP0005000_abnormal_immune_tolerance2.52533596
10MP0005025_abnormal_response_to2.46182770
11MP0001800_abnormal_humoral_immune2.23725188
12MP0002420_abnormal_adaptive_immunity2.21132692
13MP0001873_stomach_inflammation2.16544401
14MP0002723_abnormal_immune_serum2.14333543
15MP0003045_fibrosis2.13143237
16MP0001819_abnormal_immune_cell2.11674707
17MP0001790_abnormal_immune_system2.01226389
18MP0005387_immune_system_phenotype2.01226389
19MP0002006_tumorigenesis1.99142572
20MP0003878_abnormal_ear_physiology1.95619425
21MP0005377_hearing/vestibular/ear_phenot1.95619425
22MP0002148_abnormal_hypersensitivity_rea1.85425991
23MP0005645_abnormal_hypothalamus_physiol1.83009848
24MP0000685_abnormal_immune_system1.77347975
25MP0003448_altered_tumor_morphology1.71852053
26MP0002102_abnormal_ear_morphology1.69171399
27MP0002452_abnormal_antigen_presenting1.64366326
28MP0010155_abnormal_intestine_physiology1.63455487
29MP0000716_abnormal_immune_system1.61892435
30MP0001485_abnormal_pinna_reflex1.58359575
31MP0002933_joint_inflammation1.55423770
32MP0002398_abnormal_bone_marrow1.49048711
33MP0001905_abnormal_dopamine_level1.48320688
34MP0004145_abnormal_muscle_electrophysio1.44985472
35MP0004147_increased_porphyrin_level1.43524609
36MP0002405_respiratory_system_inflammati1.42868753
37MP0002638_abnormal_pupillary_reflex1.42063254
38MP0003646_muscle_fatigue1.40953824
39MP0001845_abnormal_inflammatory_respons1.39894359
40MP0000703_abnormal_thymus_morphology1.34155627
41MP0003787_abnormal_imprinting1.33416683
42MP0002722_abnormal_immune_system1.29108385
43MP0005166_decreased_susceptibility_to1.28258946
44MP0002419_abnormal_innate_immunity1.27896851
45MP0008872_abnormal_physiological_respon1.26725903
46MP0001919_abnormal_reproductive_system1.26121311
47MP0005646_abnormal_pituitary_gland1.24659321
48MP0002163_abnormal_gland_morphology1.23514764
49MP0000372_irregular_coat_pigmentation1.20846829
50MP0000689_abnormal_spleen_morphology1.20530060
51MP0002429_abnormal_blood_cell1.16231655
52MP0006072_abnormal_retinal_apoptosis1.16148465
53MP0008469_abnormal_protein_level1.14626020
54MP0003436_decreased_susceptibility_to1.12991312
55MP0003880_abnormal_central_pattern1.11761275
56MP0002693_abnormal_pancreas_physiology1.11389521
57MP0005379_endocrine/exocrine_gland_phen1.08889447
58MP0001661_extended_life_span1.08276653
59MP0004885_abnormal_endolymph1.07774512
60MP0005551_abnormal_eye_electrophysiolog1.07289326
61MP0002277_abnormal_respiratory_mucosa1.05226743
62MP0003011_delayed_dark_adaptation1.04927324
63MP0001764_abnormal_homeostasis1.03790787
64MP0001968_abnormal_touch/_nociception1.02462693
65MP0002837_dystrophic_cardiac_calcinosis0.99879551
66MP0008875_abnormal_xenobiotic_pharmacok0.99878496
67MP0004947_skin_inflammation0.99198712
68MP0005075_abnormal_melanosome_morpholog0.98593311
69MP0003786_premature_aging0.98221708
70MP0001188_hyperpigmentation0.97885713
71MP0005464_abnormal_platelet_physiology0.97779322
72MP0009763_increased_sensitivity_to0.94726770
73MP0002736_abnormal_nociception_after0.91263192
74MP0000639_abnormal_adrenal_gland0.88937584
75MP0005389_reproductive_system_phenotype0.87769552
76MP0001348_abnormal_lacrimal_gland0.87501672
77MP0009764_decreased_sensitivity_to0.87464576
78MP0004134_abnormal_chest_morphology0.87193007
79MP0001986_abnormal_taste_sensitivity0.86567206
80MP0000858_altered_metastatic_potential0.86463179
81MP0003137_abnormal_impulse_conducting0.83972146
82MP0003075_altered_response_to0.83111237
83MP0004742_abnormal_vestibular_system0.80436556
84MP0005253_abnormal_eye_physiology0.79394555
85MP0002909_abnormal_adrenal_gland0.78379604
86MP0001542_abnormal_bone_strength0.75991102
87MP0009643_abnormal_urine_homeostasis0.75164388
88MP0001984_abnormal_olfaction0.73179085
89MP0009745_abnormal_behavioral_response0.72351064
90MP0008873_increased_physiological_sensi0.71039041
91MP0001765_abnormal_ion_homeostasis0.70844265
92MP0002168_other_aberrant_phenotype0.69929978
93MP0005636_abnormal_mineral_homeostasis0.68152358
94MP0008789_abnormal_olfactory_epithelium0.67369505
95MP0008877_abnormal_DNA_methylation0.66032381
96MP0001970_abnormal_pain_threshold0.63916990
97MP0002733_abnormal_thermal_nociception0.63234794
98MP0002822_catalepsy0.60903136
99MP0002019_abnormal_tumor_incidence0.60381199
100MP0006276_abnormal_autonomic_nervous0.60096435

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.57541072
2Aplastic anemia (HP:0001915)6.24546769
3Abnormality of T cell number (HP:0011839)5.89153823
4Hypoproteinemia (HP:0003075)4.79197975
5Severe combined immunodeficiency (HP:0004430)4.71828543
6IgG deficiency (HP:0004315)4.61543703
7Elevated erythrocyte sedimentation rate (HP:0003565)4.50324138
8Absent rod-and cone-mediated responses on ERG (HP:0007688)4.17814596
9Autoimmune hemolytic anemia (HP:0001890)4.10195148
10Abnormality of T cells (HP:0002843)3.81526591
11Combined immunodeficiency (HP:0005387)3.74089281
12Thyroiditis (HP:0100646)3.73338574
13Mitochondrial inheritance (HP:0001427)3.71291074
14Increased IgM level (HP:0003496)3.68724659
15Renal Fanconi syndrome (HP:0001994)3.55037189
16Increased intramyocellular lipid droplets (HP:0012240)3.49239920
17Increased hepatocellular lipid droplets (HP:0006565)3.34341239
18Abnormal rod and cone electroretinograms (HP:0008323)3.25331175
19Acute necrotizing encephalopathy (HP:0006965)3.23800887
20Chronic diarrhea (HP:0002028)3.10061477
21Abnormal mitochondria in muscle tissue (HP:0008316)3.03280538
22Recurrent bronchitis (HP:0002837)2.98598362
23Abnormality of macrophages (HP:0004311)2.92903564
24Abnormality of eosinophils (HP:0001879)2.91937876
25Increased CSF lactate (HP:0002490)2.91777884
26Congenital stationary night blindness (HP:0007642)2.88652144
27Hepatocellular necrosis (HP:0001404)2.87987119
28Decreased activity of mitochondrial respiratory chain (HP:0008972)2.84490360
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.84490360
30B lymphocytopenia (HP:0010976)2.82954839
313-Methylglutaconic aciduria (HP:0003535)2.82942544
32Hypoalbuminemia (HP:0003073)2.79334745
33Abnormal albumin level (HP:0012116)2.79334745
34Increased muscle lipid content (HP:0009058)2.75550834
35Abnormality of B cell number (HP:0010975)2.75320960
36Progressive macrocephaly (HP:0004481)2.69230048
37Recurrent cutaneous fungal infections (HP:0011370)2.68051989
38Chronic mucocutaneous candidiasis (HP:0002728)2.68051989
39Lipid accumulation in hepatocytes (HP:0006561)2.68036808
40Encephalitis (HP:0002383)2.64991529
41Stomatitis (HP:0010280)2.64772347
42Attenuation of retinal blood vessels (HP:0007843)2.63723300
43Lymphopenia (HP:0001888)2.61580790
44Hypoplasia of the thymus (HP:0000778)2.58487995
45Bronchitis (HP:0012387)2.58007571
46Acute encephalopathy (HP:0006846)2.57661270
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.57652484
48Generalized aminoaciduria (HP:0002909)2.56268790
49Pancreatic cysts (HP:0001737)2.51057737
50Hepatic necrosis (HP:0002605)2.50690864
51Abnormality of the prostate (HP:0008775)2.45658716
52Decreased central vision (HP:0007663)2.43089900
53Exertional dyspnea (HP:0002875)2.42005551
54Severe visual impairment (HP:0001141)2.39825173
55Amyotrophic lateral sclerosis (HP:0007354)2.39739731
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.38692622
57Abnormality of cells of the lymphoid lineage (HP:0012140)2.35693206
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34995065
59Leukocytosis (HP:0001974)2.33055920
60Gastrointestinal infarctions (HP:0005244)2.32165211
61Recurrent otitis media (HP:0000403)2.30455959
62Acute hepatic failure (HP:0006554)2.29442737
63Cerebral edema (HP:0002181)2.28872252
64Meningitis (HP:0001287)2.26681802
65Hemiplegia (HP:0002301)2.25794798
66Pancreatic fibrosis (HP:0100732)2.24295931
67Abolished electroretinogram (ERG) (HP:0000550)2.20972978
68Hyponatremia (HP:0002902)2.20584566
69Cerebral palsy (HP:0100021)2.13598183
70Pancytopenia (HP:0001876)2.13237757
71True hermaphroditism (HP:0010459)2.09561956
72Abnormality of renal resorption (HP:0011038)2.05012397
73Obstructive lung disease (HP:0006536)2.04511725
74Chronic obstructive pulmonary disease (HP:0006510)2.04511725
75Lymphoma (HP:0002665)2.03582991
76Bronchiectasis (HP:0002110)2.03465228
77Increased serum lactate (HP:0002151)2.02867865
78Joint swelling (HP:0001386)2.01511450
79Abnormal delayed hypersensitivity skin test (HP:0002963)2.00631941
80Hypergammaglobulinemia (HP:0010702)2.00319187
81Chronic bronchitis (HP:0004469)1.98966420
82Pendular nystagmus (HP:0012043)1.98210423
83Optic disc pallor (HP:0000543)1.97522302
84Abnormality of midbrain morphology (HP:0002418)1.95667210
85Molar tooth sign on MRI (HP:0002419)1.95667210
86Agammaglobulinemia (HP:0004432)1.95283604
87Eosinophilia (HP:0001880)1.95039104
88Glycosuria (HP:0003076)1.91125000
89Abnormality of urine glucose concentration (HP:0011016)1.91125000
90Recurrent viral infections (HP:0004429)1.88217479
91Recurrent fungal infections (HP:0002841)1.88202769
92Constricted visual fields (HP:0001133)1.87059949
93Oral leukoplakia (HP:0002745)1.85173773
94Lactic acidosis (HP:0003128)1.84510644
95Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80427192
96Radial bowing (HP:0002986)1.80294139
97IgM deficiency (HP:0002850)1.78242789
98Alkalosis (HP:0001948)1.76463916
99Gangrene (HP:0100758)1.74154968
100Abnormal respiratory motile cilium physiology (HP:0012261)1.72146957

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR7.10765718
2TESK25.57330482
3TXK4.82284309
4BCKDK3.63180823
5MAP4K12.91781013
6TESK12.77719853
7ZAK2.60443813
8ITK2.37265894
9VRK22.36907145
10TAOK32.32385286
11LIMK12.23739460
12ADRBK22.05721730
13BUB12.01141766
14TLK11.88958603
15MAP3K121.85687260
16VRK11.70065269
17GRK71.64513919
18TEC1.63070605
19MAP3K111.55828572
20MUSK1.37734296
21SYK1.37370464
22PRKCQ1.36600300
23BTK1.31818816
24FES1.28970009
25GRK11.28609490
26EIF2AK31.26544178
27PIK3CA1.25784313
28GRK61.19442901
29CSK1.18176770
30LCK1.17578109
31ZAP701.15671832
32TNK21.15046108
33MYLK1.02542026
34SCYL20.98018831
35FRK0.93487282
36LYN0.91831326
37CDK190.87855839
38TIE10.86925660
39INSRR0.80491107
40MAPKAPK30.76449225
41WNK40.75335572
42ROCK10.70856121
43DAPK10.69794039
44NUAK10.64761854
45CSNK1G30.63991389
46RPS6KA50.63815978
47MST40.61517466
48NME10.59731154
49TYRO30.59036051
50FYN0.58860678
51RPS6KA40.58026649
52TBK10.57675040
53WNK30.57481845
54OBSCN0.55812325
55MAP4K20.55764232
56JAK30.53010227
57PASK0.51482458
58PIM10.50891335
59AURKA0.49140416
60INSR0.48597831
61IKBKE0.48082253
62PIK3CG0.47073253
63IGF1R0.46841888
64KIT0.46704428
65PRKCA0.44867962
66PRKCH0.44644110
67CSF1R0.43886347
68PAK10.43643705
69CSNK1G20.42584721
70LRRK20.41880809
71BLK0.41071923
72ADRBK10.41034435
73GRK50.37794958
74CSNK1A1L0.37337182
75PRKACA0.36672888
76DAPK30.36004734
77MATK0.35704690
78TRIM280.34884226
79HCK0.34683048
80MAP3K50.34613244
81PINK10.34286353
82CSNK1G10.33948226
83MAPK130.31616892
84RIPK40.30024681
85CAMK2A0.29887996
86IKBKB0.29804718
87MAP2K70.29668979
88MAP2K60.29297379
89CLK10.28646986
90NTRK20.26650481
91LMTK20.26365908
92CSNK1A10.25876316
93MAPK150.25791027
94PIM20.24089039
95SRC0.23470138
96ERBB20.22659267
97CSNK2A10.21772756
98OXSR10.21511673
99PRKCB0.20483438
100ABL10.18704994

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.42809418
2Proteasome_Homo sapiens_hsa030504.15321710
3Oxidative phosphorylation_Homo sapiens_hsa001903.39789558
4Antigen processing and presentation_Homo sapiens_hsa046123.23682425
5Graft-versus-host disease_Homo sapiens_hsa053323.00059308
6Hematopoietic cell lineage_Homo sapiens_hsa046402.95873302
7Parkinsons disease_Homo sapiens_hsa050122.88889403
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.75851675
9Autoimmune thyroid disease_Homo sapiens_hsa053202.73450098
10Allograft rejection_Homo sapiens_hsa053302.61150359
11T cell receptor signaling pathway_Homo sapiens_hsa046602.56950262
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.47818080
13Type I diabetes mellitus_Homo sapiens_hsa049402.10609373
14Alzheimers disease_Homo sapiens_hsa050101.95937092
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.83654821
16Huntingtons disease_Homo sapiens_hsa050161.73148308
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70334685
18Cardiac muscle contraction_Homo sapiens_hsa042601.67473353
19Ribosome_Homo sapiens_hsa030101.62887931
20Rheumatoid arthritis_Homo sapiens_hsa053231.61239216
21Phototransduction_Homo sapiens_hsa047441.59708833
22RNA polymerase_Homo sapiens_hsa030201.59164080
23Salmonella infection_Homo sapiens_hsa051321.55286534
24Protein export_Homo sapiens_hsa030601.43457237
25Measles_Homo sapiens_hsa051621.41810732
26Malaria_Homo sapiens_hsa051441.37253831
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36008284
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32820215
29Caffeine metabolism_Homo sapiens_hsa002321.30250610
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.16570329
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05655418
32Peroxisome_Homo sapiens_hsa041461.05268338
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.03670846
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02509938
35Nitrogen metabolism_Homo sapiens_hsa009100.99675185
36Viral myocarditis_Homo sapiens_hsa054160.99503180
37Asthma_Homo sapiens_hsa053100.93493966
38Shigellosis_Homo sapiens_hsa051310.92686989
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88578118
40SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83985180
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81379833
42Primary bile acid biosynthesis_Homo sapiens_hsa001200.80798546
43Olfactory transduction_Homo sapiens_hsa047400.78471110
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76358192
45Butanoate metabolism_Homo sapiens_hsa006500.75846932
46Linoleic acid metabolism_Homo sapiens_hsa005910.75721022
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72661554
48Retinol metabolism_Homo sapiens_hsa008300.71854366
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.64463566
50Systemic lupus erythematosus_Homo sapiens_hsa053220.64344090
51Collecting duct acid secretion_Homo sapiens_hsa049660.63721768
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61272507
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58677683
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57734658
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.57622809
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57562949
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56787696
58Chemokine signaling pathway_Homo sapiens_hsa040620.56649074
59Chemical carcinogenesis_Homo sapiens_hsa052040.53425353
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52823906
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46621001
62Purine metabolism_Homo sapiens_hsa002300.45565859
63One carbon pool by folate_Homo sapiens_hsa006700.45145801
64ABC transporters_Homo sapiens_hsa020100.42726255
65Nicotine addiction_Homo sapiens_hsa050330.42680870
66Staphylococcus aureus infection_Homo sapiens_hsa051500.41281534
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40791516
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39865651
69Pyrimidine metabolism_Homo sapiens_hsa002400.39742582
70Taste transduction_Homo sapiens_hsa047420.39574484
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37844599
72Prion diseases_Homo sapiens_hsa050200.36370793
73Morphine addiction_Homo sapiens_hsa050320.33921268
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32482330
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.32384764
76Herpes simplex infection_Homo sapiens_hsa051680.32082793
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29649268
78HTLV-I infection_Homo sapiens_hsa051660.26850732
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26768283
80RNA degradation_Homo sapiens_hsa030180.24165958
81Metabolic pathways_Homo sapiens_hsa011000.23798902
82Regulation of autophagy_Homo sapiens_hsa041400.23372742
83Alcoholism_Homo sapiens_hsa050340.23225861
84Epstein-Barr virus infection_Homo sapiens_hsa051690.21220422
85Pertussis_Homo sapiens_hsa051330.20201950
86GABAergic synapse_Homo sapiens_hsa047270.20000225
87Legionellosis_Homo sapiens_hsa051340.19764432
88Endocytosis_Homo sapiens_hsa041440.19455939
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.19352622
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.19256803
91Leishmaniasis_Homo sapiens_hsa051400.15953210
92Mineral absorption_Homo sapiens_hsa049780.15634230
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.15452359
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14884593
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.13625839
96Homologous recombination_Homo sapiens_hsa034400.12870169
97Tyrosine metabolism_Homo sapiens_hsa003500.12224764
98Arachidonic acid metabolism_Homo sapiens_hsa005900.11668165
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.11563942
100Tryptophan metabolism_Homo sapiens_hsa003800.11538564

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