ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrion distribution (GO:0048311)	4.86679222
2	response to gravity (GO:0009629)	4.66926408
3	regulation of T-helper 1 cell differentiation (GO:0045625)	4.65885096
4	cellular response to zinc ion (GO:0071294)	4.46109717
5	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	4.34268743
6	cellular response to vitamin D (GO:0071305)	4.27858895
7	NIK/NF-kappaB signaling (GO:0038061)	4.18824265
8	T cell lineage commitment (GO:0002360)	4.10214460
9	short-term memory (GO:0007614)	4.02291909
10	regulation of protein heterodimerization activity (GO:0043497)	3.98599971
11	cellular response to arsenic-containing substance (GO:0071243)	3.97980449
12	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.88714512
13	chemosensory behavior (GO:0007635)	3.80878797
14	mitotic G1 DNA damage checkpoint (GO:0031571)	3.68769182
15	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	3.63560733
16	mitotic G1/S transition checkpoint (GO:0044819)	3.60648085
17	nucleoside diphosphate catabolic process (GO:0009134)	3.59102312
18	purine ribonucleoside diphosphate metabolic process (GO:0009179)	3.57570376
19	purine nucleoside diphosphate metabolic process (GO:0009135)	3.57570376
20	activation of MAPKKK activity (GO:0000185)	3.56370694
21	cellular response to interferon-beta (GO:0035458)	3.55432227
22	positive regulation of lymphocyte apoptotic process (GO:0070230)	3.54145705
23	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	3.50987005
24	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	3.50987005
25	negative regulation of mast cell activation (GO:0033004)	3.48650119
26	positive regulation of interferon-gamma biosynthetic process (GO:0045078)	3.46798468
27	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.46000780
28	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042)	3.41940664
29	DNA deamination (GO:0045006)	3.41087483
30	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	3.38574707
31	release of cytochrome c from mitochondria (GO:0001836)	3.28973086
32	regulation of penile erection (GO:0060405)	3.25278896
33	DNA damage response, signal transduction resulting in transcription (GO:0042772)	3.22060090
34	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	3.21252148
35	G1 DNA damage checkpoint (GO:0044783)	3.20235416
36	regulation of autophagic vacuole assembly (GO:2000785)	3.19965225
37	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.17411205
38	regulation of interferon-gamma biosynthetic process (GO:0045072)	3.16982095
39	protein targeting to ER (GO:0045047)	3.15632547
40	kynurenine metabolic process (GO:0070189)	3.14941042
41	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling	3.14123243
42	adaptation of signaling pathway (GO:0023058)	3.12974827
43	cytidine metabolic process (GO:0046087)	3.10571115
44	cytidine catabolic process (GO:0006216)	3.10571115
45	cytidine deamination (GO:0009972)	3.10571115
46	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.08637880
47	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.07442665
48	cotranslational protein targeting to membrane (GO:0006613)	3.05332135
49	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.04350531
50	positive regulation of T cell apoptotic process (GO:0070234)	3.04339142
51	T cell apoptotic process (GO:0070231)	3.01858762
52	positive regulation of T-helper 1 type immune response (GO:0002827)	3.01626485
53	regulation of dendritic cell antigen processing and presentation (GO:0002604)	2.99553776
54	viral transcription (GO:0019083)	2.99381736
55	positive regulation of muscle cell apoptotic process (GO:0010661)	2.98646117
56	endoderm formation (GO:0001706)	2.98377049
57	tryptophan catabolic process (GO:0006569)	2.98113618
58	indole-containing compound catabolic process (GO:0042436)	2.98113618
59	indolalkylamine catabolic process (GO:0046218)	2.98113618
60	protein localization to endoplasmic reticulum (GO:0070972)	2.96355999
61	negative regulation of JUN kinase activity (GO:0043508)	2.96314647
62	specification of organ identity (GO:0010092)	2.95300764
63	positive regulation of protein deacetylation (GO:0090312)	2.94743735
64	response to type I interferon (GO:0034340)	2.93313821
65	positive regulation of antigen processing and presentation (GO:0002579)	2.92756200
66	type I interferon signaling pathway (GO:0060337)	2.92312951
67	cellular response to type I interferon (GO:0071357)	2.92312951
68	translational termination (GO:0006415)	2.92144634
69	tachykinin receptor signaling pathway (GO:0007217)	2.91860423
70	positive regulation of neurotransmitter transport (GO:0051590)	2.90617306
71	ribosomal small subunit assembly (GO:0000028)	2.84101311
72	regulation of protein homodimerization activity (GO:0043496)	2.83872147
73	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	2.83833913
74	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.82156815
75	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.80631290
76	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	2.79661650
77	T cell migration (GO:0072678)	2.79215523
78	positive regulation of protein oligomerization (GO:0032461)	2.79135335
79	negative regulation of viral genome replication (GO:0045071)	2.78277243
80	ribonucleoside diphosphate metabolic process (GO:0009185)	2.77872016
81	cellular response to vitamin (GO:0071295)	2.75480072
82	response to histamine (GO:0034776)	2.70148327
83	myeloid dendritic cell differentiation (GO:0043011)	2.69724400
84	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.69022452
85	isotype switching (GO:0045190)	2.69022452
86	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.69022452
87	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.68074929
88	regulation of antigen processing and presentation (GO:0002577)	2.67053339
89	regulation of vacuole organization (GO:0044088)	2.66377851
90	tryptophan metabolic process (GO:0006568)	2.65586753
91	positive regulation of NF-kappaB import into nucleus (GO:0042346)	2.64756312
92	interferon-gamma-mediated signaling pathway (GO:0060333)	2.63844824
93	pyrimidine-containing compound salvage (GO:0008655)	2.62318150
94	pyrimidine nucleoside salvage (GO:0043097)	2.62318150
95	T-helper 1 type immune response (GO:0042088)	2.61127708
96	positive regulation of interleukin-2 production (GO:0032743)	2.61092034
97	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.60096399
98	positive regulation of DNA biosynthetic process (GO:2000573)	2.59693733
99	programmed necrotic cell death (GO:0097300)	2.57792200
100	lymphocyte apoptotic process (GO:0070227)	2.57597063

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.33181940
2	E2F7_22180533_ChIP-Seq_HELA_Human	3.16143511
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.97479386
4	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.85314711
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.77418659
6	MYC_22102868_ChIP-Seq_BL_Human	2.68301889
7	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.54436976
8	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.29750844
9	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.21975387
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.20937277
11	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	2.14012616
12	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.07562567
13	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.06185474
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.05272711
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.98535434
16	LXR_22292898_ChIP-Seq_THP-1_Human	1.98251642
17	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.91431437
18	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.81455564
19	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.81444601
20	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.80006148
21	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.79201444
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.78918499
23	CIITA_25753668_ChIP-Seq_RAJI_Human	1.75957005
24	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.72510682
25	XRN2_22483619_ChIP-Seq_HELA_Human	1.70189290
26	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.67808828
27	TP53_22127205_ChIP-Seq_IMR90_Human	1.66923498
28	P68_20966046_ChIP-Seq_HELA_Human	1.65506528
29	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.65234896
30	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.64601195
31	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.63263134
32	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.60068379
33	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.59476097
34	BCL6_27268052_Chip-Seq_Bcells_Human	1.59422001
35	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.58488949
36	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.54303563
37	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.53914108
38	DCP1A_22483619_ChIP-Seq_HELA_Human	1.53598801
39	MAF_26560356_Chip-Seq_TH1_Human	1.50960351
40	VDR_21846776_ChIP-Seq_THP-1_Human	1.49428255
41	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.45240958
42	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.44016862
43	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.40858305
44	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.39219664
45	MAF_26560356_Chip-Seq_TH2_Human	1.38879470
46	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.37172371
47	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.34608577
48	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.34411657
49	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.34102341
50	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.33314148
51	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.31136937
52	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.29539985
53	TFEB_21752829_ChIP-Seq_HELA_Human	1.28056879
54	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.26889863
55	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.25936008
56	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.25428614
57	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.24738603
58	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.23842780
59	BCOR_27268052_Chip-Seq_Bcells_Human	1.16446884
60	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.16127152
61	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.15547379
62	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.13939753
63	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.13715373
64	GABP_19822575_ChIP-Seq_HepG2_Human	1.11937546
65	SPI1_23547873_ChIP-Seq_NB4_Human	1.11496718
66	FOXP3_21729870_ChIP-Seq_TREG_Human	1.10938971
67	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.10904914
68	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.09905509
69	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.08782820
70	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.08505447
71	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.08504804
72	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.08222621
73	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.08097282
74	PHF8_20622854_ChIP-Seq_HELA_Human	1.07719836
75	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.07709878
76	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.07498728
77	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.07061158
78	KDM5A_27292631_Chip-Seq_BREAST_Human	1.07027412
79	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.06333180
80	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.04945881
81	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.04828024
82	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.04043894
83	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.03508914
84	E2F1_20622854_ChIP-Seq_HELA_Human	1.02968672
85	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.99964436
86	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.99454709
87	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.98946377
88	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98621906
89	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.98112441
90	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.97636147
91	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.96314700
92	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.96072249
93	SA1_27219007_Chip-Seq_Bcells_Human	0.94336232
94	RACK7_27058665_Chip-Seq_MCF-7_Human	0.93630270
95	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.93398432
96	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.92705590
97	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.92366655
98	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.91884742
99	IRF1_19129219_ChIP-ChIP_H3396_Human	0.91759376
100	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.91552310

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002163_abnormal_gland_morphology	5.34888147
2	MP0005623_abnormal_meninges_morphology	4.16067347
3	MP0005379_endocrine/exocrine_gland_phen	3.60410728
4	MP0001348_abnormal_lacrimal_gland	3.59085912
5	MP0003806_abnormal_nucleotide_metabolis	3.55268837
6	MP0009333_abnormal_splenocyte_physiolog	3.31500103
7	MP0000685_abnormal_immune_system	3.28841031
8	MP0010368_abnormal_lymphatic_system	3.10152148
9	MP0002166_altered_tumor_susceptibility	3.03057437
10	MP0004885_abnormal_endolymph	2.80576732
11	MP0005671_abnormal_response_to	2.74571468
12	MP0005084_abnormal_gallbladder_morpholo	2.45093829
13	MP0002006_tumorigenesis	2.43043860
14	MP0001790_abnormal_immune_system	2.27363834
15	MP0005387_immune_system_phenotype	2.27363834
16	MP0004145_abnormal_muscle_electrophysio	2.22645877
17	MP0001835_abnormal_antigen_presentation	2.21451915
18	MP0005451_abnormal_body_composition	2.18800029
19	MP0009053_abnormal_anal_canal	2.06065844
20	MP0005000_abnormal_immune_tolerance	2.02938484
21	MP0001800_abnormal_humoral_immune	1.94117373
22	MP0004185_abnormal_adipocyte_glucose	1.79226817
23	MP0002138_abnormal_hepatobiliary_system	1.74242774
24	MP0002928_abnormal_bile_duct	1.70644357
25	MP0005220_abnormal_exocrine_pancreas	1.68462147
26	MP0002723_abnormal_immune_serum	1.65429604
27	MP0005423_abnormal_somatic_nervous	1.62869538
28	MP0002452_abnormal_antigen_presenting	1.52844623
29	MP0002148_abnormal_hypersensitivity_rea	1.50880265
30	MP0001944_abnormal_pancreas_morphology	1.46985760
31	MP0001542_abnormal_bone_strength	1.45173938
32	MP0002693_abnormal_pancreas_physiology	1.44330216
33	MP0002420_abnormal_adaptive_immunity	1.36990276
34	MP0001819_abnormal_immune_cell	1.35609769
35	MP0003186_abnormal_redox_activity	1.33679448
36	MP0003787_abnormal_imprinting	1.31248225
37	MP0002398_abnormal_bone_marrow	1.30778541
38	MP0001905_abnormal_dopamine_level	1.30453004
39	MP0001853_heart_inflammation	1.29099413
40	MP0000613_abnormal_salivary_gland	1.26953125
41	MP0000716_abnormal_immune_system	1.24516022
42	MP0000358_abnormal_cell_content/	1.21835383
43	MP0009785_altered_susceptibility_to	1.21579198
44	MP0009379_abnormal_foot_pigmentation	1.20988412
45	MP0002429_abnormal_blood_cell	1.19950291
46	MP0000858_altered_metastatic_potential	1.14478152
47	MP0003950_abnormal_plasma_membrane	1.13293812
48	MP0005025_abnormal_response_to	1.11240994
49	MP0003786_premature_aging	1.09071853
50	MP0002405_respiratory_system_inflammati	1.07372256
51	MP0003868_abnormal_feces_composition	1.07337442
52	MP0003045_fibrosis	1.03253189
53	MP0005193_abnormal_anterior_eye	1.01054905
54	MP0006035_abnormal_mitochondrial_morpho	1.00547609
55	MP0001845_abnormal_inflammatory_respons	0.99095818
56	MP0010094_abnormal_chromosome_stability	0.98768752
57	MP0003693_abnormal_embryo_hatching	0.97863894
58	MP0003303_peritoneal_inflammation	0.97260887
59	MP0006036_abnormal_mitochondrial_physio	0.94554549
60	MP0003763_abnormal_thymus_physiology	0.93569165
61	MP0010234_abnormal_vibrissa_follicle	0.92731455
62	MP0005310_abnormal_salivary_gland	0.92653395
63	MP0000689_abnormal_spleen_morphology	0.89522965
64	MP0005501_abnormal_skin_physiology	0.89330926
65	MP0001440_abnormal_grooming_behavior	0.89009743
66	MP0003943_abnormal_hepatobiliary_system	0.87976461
67	MP0001879_abnormal_lymphatic_vessel	0.87530235
68	MP0003091_abnormal_cell_migration	0.85963088
69	MP0004947_skin_inflammation	0.84330541
70	MP0005666_abnormal_adipose_tissue	0.83331866
71	MP0002722_abnormal_immune_system	0.81460049
72	MP0003111_abnormal_nucleus_morphology	0.79124886
73	MP0002132_abnormal_respiratory_system	0.78482577
74	MP0001485_abnormal_pinna_reflex	0.78451260
75	MP0002136_abnormal_kidney_physiology	0.77216621
76	MP0008007_abnormal_cellular_replicative	0.76849143
77	MP0002089_abnormal_postnatal_growth/wei	0.75960245
78	MP0003123_paternal_imprinting	0.74643792
79	MP0001661_extended_life_span	0.73956288
80	MP0009764_decreased_sensitivity_to	0.71999096
81	MP0000462_abnormal_digestive_system	0.70681566
82	MP0003436_decreased_susceptibility_to	0.69844346
83	MP0002796_impaired_skin_barrier	0.68435322
84	MP0001216_abnormal_epidermal_layer	0.66597237
85	MP0000343_altered_response_to	0.66498469
86	MP0009643_abnormal_urine_homeostasis	0.66432085
87	MP0005381_digestive/alimentary_phenotyp	0.65470141
88	MP0009115_abnormal_fat_cell	0.61303934
89	MP0002653_abnormal_ependyma_morphology	0.61216173
90	MP0010307_abnormal_tumor_latency	0.60139665
91	MP0003011_delayed_dark_adaptation	0.59926854
92	MP0005448_abnormal_energy_balance	0.59175819
93	MP0000703_abnormal_thymus_morphology	0.57868965
94	MP0003453_abnormal_keratinocyte_physiol	0.56460891
95	MP0002060_abnormal_skin_morphology	0.54988556
96	MP0004957_abnormal_blastocyst_morpholog	0.54155268
97	MP0002638_abnormal_pupillary_reflex	0.54037687
98	MP0005375_adipose_tissue_phenotype	0.53970273
99	MP0003879_abnormal_hair_cell	0.53596200
100	MP0002419_abnormal_innate_immunity	0.53004436

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Papilledema (HP:0001085)	4.89245759
2	Abnormal pancreas size (HP:0012094)	4.52809680
3	Neoplasm of the adrenal cortex (HP:0100641)	4.03745626
4	Abnormality of cochlea (HP:0000375)	3.96336958
5	Poikiloderma (HP:0001029)	3.66869930
6	Agammaglobulinemia (HP:0004432)	3.45260919
7	IgA deficiency (HP:0002720)	3.38215632
8	Exertional dyspnea (HP:0002875)	3.31282961
9	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.30613164
10	Gastrointestinal stroma tumor (HP:0100723)	3.16244624
11	Diastasis recti (HP:0001540)	3.14359382
12	Renal Fanconi syndrome (HP:0001994)	3.13933682
13	Congenital stationary night blindness (HP:0007642)	3.10788123
14	Squamous cell carcinoma (HP:0002860)	3.09687751
15	Onycholysis (HP:0001806)	3.06931115
16	Lipid accumulation in hepatocytes (HP:0006561)	3.06706270
17	Pustule (HP:0200039)	2.98578067
18	Lymphopenia (HP:0001888)	2.95181000
19	Premature loss of primary teeth (HP:0006323)	2.91227583
20	Panhypogammaglobulinemia (HP:0003139)	2.90646611
21	Hypertensive crisis (HP:0100735)	2.86360562
22	Increased hepatocellular lipid droplets (HP:0006565)	2.81853020
23	Increased density of long bones (HP:0006392)	2.75331055
24	Abnormality of cells of the lymphoid lineage (HP:0012140)	2.74974787
25	Recurrent viral infections (HP:0004429)	2.73145508
26	Persistence of primary teeth (HP:0006335)	2.71488070
27	Morphological abnormality of the inner ear (HP:0011390)	2.69208519
28	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.67147859
29	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.66261686
30	Aplasia/Hypoplasia of the thymus (HP:0010515)	2.58537843
31	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.58417557
32	Neonatal hypoglycemia (HP:0001998)	2.57053226
33	Shawl scrotum (HP:0000049)	2.55029395
34	Fetal akinesia sequence (HP:0001989)	2.54029142
35	Abnormality of placental membranes (HP:0011409)	2.52009503
36	Amniotic constriction ring (HP:0009775)	2.52009503
37	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.46479083
38	Metaphyseal dysplasia (HP:0100255)	2.45784046
39	Porencephaly (HP:0002132)	2.39236853
40	Ridged nail (HP:0001807)	2.38036746
41	Turricephaly (HP:0000262)	2.33287010
42	Fragile nails (HP:0001808)	2.32523781
43	Adrenal hypoplasia (HP:0000835)	2.30428573
44	Hyperparathyroidism (HP:0000843)	2.30111078
45	Parakeratosis (HP:0001036)	2.22917363
46	Increased intramyocellular lipid droplets (HP:0012240)	2.22044345
47	Amaurosis fugax (HP:0100576)	2.19944502
48	Increased muscle lipid content (HP:0009058)	2.18682281
49	Horseshoe kidney (HP:0000085)	2.18012252
50	Tongue fasciculations (HP:0001308)	2.17998958
51	Chronic hepatic failure (HP:0100626)	2.17285301
52	Abnormality of T cell physiology (HP:0011840)	2.15280088
53	Prolonged neonatal jaundice (HP:0006579)	2.15173744
54	Reticulocytopenia (HP:0001896)	2.12285136
55	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.11462959
56	Viral hepatitis (HP:0006562)	2.11192332
57	Acrocyanosis (HP:0001063)	2.11034473
58	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.08361257
59	Asplenia (HP:0001746)	2.06467116
60	Abnormal rod and cone electroretinograms (HP:0008323)	2.05871034
61	Recurrent bronchitis (HP:0002837)	2.05106050
62	Prominent metopic ridge (HP:0005487)	2.03140673
63	Plagiocephaly (HP:0001357)	2.00983447
64	Lissencephaly (HP:0001339)	1.99805542
65	IgG deficiency (HP:0004315)	1.99525682
66	Thrombocytosis (HP:0001894)	1.97491147
67	Colitis (HP:0002583)	1.97035586
68	Recurrent lower respiratory tract infections (HP:0002783)	1.96466820
69	Rectovaginal fistula (HP:0000143)	1.95883153
70	Rectal fistula (HP:0100590)	1.95883153
71	Spinal muscular atrophy (HP:0007269)	1.94960184
72	Recurrent sinusitis (HP:0011108)	1.94378491
73	Hyperthyroidism (HP:0000836)	1.94037579
74	Severe muscular hypotonia (HP:0006829)	1.92355131
75	Abnormality of the preputium (HP:0100587)	1.91111727
76	Elevated erythrocyte sedimentation rate (HP:0003565)	1.91043914
77	Abnormality of the thymus (HP:0000777)	1.90798072
78	Impaired platelet aggregation (HP:0003540)	1.89133919
79	Abnormal platelet function (HP:0011869)	1.89133919
80	Macrocytic anemia (HP:0001972)	1.88842225
81	Vasculitis (HP:0002633)	1.88146913
82	Abnormality of renal resorption (HP:0011038)	1.87186325
83	Increased CSF lactate (HP:0002490)	1.86270907
84	Nasal polyposis (HP:0100582)	1.86243640
85	Ankyloglossia (HP:0010296)	1.86192582
86	Meningitis (HP:0001287)	1.86009051
87	Emphysema (HP:0002097)	1.85727778
88	Xerostomia (HP:0000217)	1.84283277
89	Recurrent bacterial skin infections (HP:0005406)	1.82116431
90	Prominent occiput (HP:0000269)	1.81367561
91	Pallor (HP:0000980)	1.80880720
92	Leukopenia (HP:0001882)	1.80513915
93	Neutropenia (HP:0001875)	1.80076706
94	Abnormality of oral frenula (HP:0000190)	1.80012413
95	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.78118429
96	Abnormality of cells of the erythroid lineage (HP:0012130)	1.75924857
97	Pigmentary retinal degeneration (HP:0001146)	1.73718631
98	Absent thumb (HP:0009777)	1.73512338
99	Papilloma (HP:0012740)	1.73318725
100	Verrucae (HP:0200043)	1.73318725

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PRPF4B	6.70032483
2	VRK2	4.63354653
3	SMG1	4.57854004
4	TAF1	4.24965769
5	TAOK2	4.06855672
6	NME2	3.32471186
7	IRAK3	3.06207595
8	SIK2	2.79896435
9	STK24	2.09932177
10	NUAK1	2.04853630
11	EPHB2	2.02560969
12	MAP3K9	1.96006709
13	ERBB4	1.84176732
14	LIMK1	1.63305693
15	MAP2K6	1.59138401
16	CDK19	1.44253281
17	PRKCI	1.37867995
18	PHKG1	1.36290573
19	PHKG2	1.36290573
20	CLK1	1.33530470
21	MAP4K1	1.23703007
22	CDC7	1.19277274
23	ARAF	1.16153442
24	MAPKAPK5	1.15348366
25	ILK	1.13331072
26	BUB1	1.11844476
27	SIK3	1.08840936
28	STK3	1.05869059
29	PASK	1.05480591
30	TESK1	1.03985588
31	WEE1	1.00766757
32	STK38L	0.99851299
33	IKBKB	0.96469445
34	IRAK4	0.95383414
35	PIM2	0.92790365
36	VRK1	0.89006964
37	MAP3K13	0.87970959
38	STK4	0.86675012
39	TYRO3	0.85555583
40	DAPK3	0.85464943
41	TBK1	0.84236613
42	DAPK1	0.83313821
43	MAP3K14	0.81399531
44	FLT3	0.80689363
45	RIPK4	0.76586402
46	STK11	0.75344996
47	MARK2	0.74182033
48	PLK3	0.68910251
49	JAK3	0.65894693
50	PTK2B	0.65501379
51	TYK2	0.64638563
52	ZAP70	0.61817513
53	RIPK1	0.61670963
54	PTK2	0.60104960
55	IKBKE	0.60033179
56	CSK	0.58712159
57	NEK1	0.56976163
58	PLK2	0.56455020
59	ABL2	0.55738279
60	MAPK11	0.55080544
61	CDK9	0.54753469
62	PRKCQ	0.53684748
63	PRKCH	0.53632895
64	EEF2K	0.53574208
65	SYK	0.52423156
66	NTRK1	0.51785916
67	MAP2K3	0.49539202
68	DMPK	0.48419014
69	DAPK2	0.47395149
70	CHEK2	0.45807988
71	NEK2	0.44968114
72	CDK8	0.44744920
73	CDK14	0.43917601
74	RPS6KA2	0.42601982
75	MAP3K6	0.42188237
76	MARK3	0.40822208
77	OXSR1	0.40545122
78	MAP3K11	0.37766381
79	PRKAA1	0.36152268
80	EIF2AK2	0.35621209
81	CSF1R	0.34800926
82	HIPK2	0.33802197
83	CSNK1G3	0.31273736
84	MAP3K12	0.30810865
85	CAMKK1	0.29985605
86	PTK6	0.29923045
87	PAK4	0.28123369
88	GRK5	0.27859402
89	CDK15	0.26658941
90	RPS6KA4	0.26129086
91	NEK9	0.25435092
92	IRAK1	0.24861212
93	EPHB1	0.24362010
94	CDK11A	0.24220016
95	LCK	0.24147494
96	PRKCD	0.23033208
97	PRKCZ	0.22836024
98	DYRK2	0.22674864
99	TTK	0.22530678
100	CSNK1A1L	0.22460827

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Intestinal immune network for IgA production_Homo sapiens_hsa04672	4.06466628
2	Protein export_Homo sapiens_hsa03060	3.66076420
3	Allograft rejection_Homo sapiens_hsa05330	3.47904359
4	Type I diabetes mellitus_Homo sapiens_hsa04940	3.08619376
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.88153943
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.80789781
7	Ribosome_Homo sapiens_hsa03010	2.53278440
8	Asthma_Homo sapiens_hsa05310	2.52028901
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.37093236
10	Proteasome_Homo sapiens_hsa03050	2.19541943
11	Viral myocarditis_Homo sapiens_hsa05416	2.11332565
12	NF-kappa B signaling pathway_Homo sapiens_hsa04064	2.04594187
13	Rheumatoid arthritis_Homo sapiens_hsa05323	1.94047826
14	Leishmaniasis_Homo sapiens_hsa05140	1.91555053
15	Sulfur relay system_Homo sapiens_hsa04122	1.90312718
16	One carbon pool by folate_Homo sapiens_hsa00670	1.81920539
17	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.80144664
18	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.56595260
19	p53 signaling pathway_Homo sapiens_hsa04115	1.54978400
20	Antigen processing and presentation_Homo sapiens_hsa04612	1.53087386
21	Shigellosis_Homo sapiens_hsa05131	1.45361095
22	DNA replication_Homo sapiens_hsa03030	1.41606405
23	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.39381985
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.35852414
25	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.28662078
26	Apoptosis_Homo sapiens_hsa04210	1.26902852
27	Measles_Homo sapiens_hsa05162	1.24980362
28	Bladder cancer_Homo sapiens_hsa05219	1.23272381
29	Influenza A_Homo sapiens_hsa05164	1.22765907
30	Herpes simplex infection_Homo sapiens_hsa05168	1.22126225
31	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.22090043
32	Salmonella infection_Homo sapiens_hsa05132	1.21724191
33	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.17431877
34	Vibrio cholerae infection_Homo sapiens_hsa05110	1.17394363
35	Pyrimidine metabolism_Homo sapiens_hsa00240	1.10114446
36	TNF signaling pathway_Homo sapiens_hsa04668	1.09434537
37	Phagosome_Homo sapiens_hsa04145	1.09395997
38	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.08459061
39	Collecting duct acid secretion_Homo sapiens_hsa04966	1.08044887
40	Base excision repair_Homo sapiens_hsa03410	1.06851805
41	Toxoplasmosis_Homo sapiens_hsa05145	1.06443282
42	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.02876268
43	Folate biosynthesis_Homo sapiens_hsa00790	1.01231555
44	Nucleotide excision repair_Homo sapiens_hsa03420	1.00753003
45	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.00367853
46	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.97469175
47	Tuberculosis_Homo sapiens_hsa05152	0.96860605
48	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.91408217
49	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.88599191
50	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.87217996
51	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.86594597
52	VEGF signaling pathway_Homo sapiens_hsa04370	0.86516329
53	Oxidative phosphorylation_Homo sapiens_hsa00190	0.85387638
54	Hepatitis B_Homo sapiens_hsa05161	0.83957082
55	Prion diseases_Homo sapiens_hsa05020	0.81043700
56	Small cell lung cancer_Homo sapiens_hsa05222	0.80574541
57	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.78720068
58	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.78450239
59	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.74947661
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.74782136
61	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.73493721
62	RNA degradation_Homo sapiens_hsa03018	0.70293605
63	Other glycan degradation_Homo sapiens_hsa00511	0.69722364
64	Cell cycle_Homo sapiens_hsa04110	0.68246069
65	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.67906751
66	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.66362535
67	HTLV-I infection_Homo sapiens_hsa05166	0.66190846
68	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.66180674
69	Osteoclast differentiation_Homo sapiens_hsa04380	0.63900287
70	Prolactin signaling pathway_Homo sapiens_hsa04917	0.60151514
71	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.57563220
72	ErbB signaling pathway_Homo sapiens_hsa04012	0.56542427
73	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.55479826
74	Hepatitis C_Homo sapiens_hsa05160	0.55466352
75	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.55425979
76	Tryptophan metabolism_Homo sapiens_hsa00380	0.53355790
77	Alzheimers disease_Homo sapiens_hsa05010	0.48463799
78	Endocytosis_Homo sapiens_hsa04144	0.47848963
79	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.47357748
80	Renal cell carcinoma_Homo sapiens_hsa05211	0.44323979
81	Proteoglycans in cancer_Homo sapiens_hsa05205	0.43379769
82	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.42727439
83	Focal adhesion_Homo sapiens_hsa04510	0.41214460
84	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.40506988
85	Parkinsons disease_Homo sapiens_hsa05012	0.39825207
86	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.39206103
87	Pancreatic cancer_Homo sapiens_hsa05212	0.38731800
88	Malaria_Homo sapiens_hsa05144	0.38129657
89	MAPK signaling pathway_Homo sapiens_hsa04010	0.34830783
90	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.34490590
91	Chemokine signaling pathway_Homo sapiens_hsa04062	0.34333181
92	mRNA surveillance pathway_Homo sapiens_hsa03015	0.32780878
93	Fanconi anemia pathway_Homo sapiens_hsa03460	0.32571675
94	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.31298571
95	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.31205597
96	Renin-angiotensin system_Homo sapiens_hsa04614	0.29461605
97	Pertussis_Homo sapiens_hsa05133	0.29363681
98	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.29001496
99	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.27860105
100	Melanoma_Homo sapiens_hsa05218	0.27047596

RPS26P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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