ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	4.95629958
2	behavioral response to nicotine (GO:0035095)	4.95317419
3	base-excision repair, AP site formation (GO:0006285)	4.89878788
4	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.71916354
5	ubiquinone biosynthetic process (GO:0006744)	4.23058031
6	facial nerve structural organization (GO:0021612)	4.21804366
7	ATP synthesis coupled proton transport (GO:0015986)	4.13565069
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.13565069
9	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.12379233
10	NADH dehydrogenase complex assembly (GO:0010257)	4.12379233
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.12379233
12	chaperone mediated protein folding requiring cofactor (GO:0051085)	4.10314575
13	DNA deamination (GO:0045006)	4.09504012
14	polyamine biosynthetic process (GO:0006596)	4.09498285
15	protein complex biogenesis (GO:0070271)	3.98743997
16	interferon-gamma secretion (GO:0072643)	3.92713764
17	respiratory chain complex IV assembly (GO:0008535)	3.85251996
18	protein neddylation (GO:0045116)	3.82258994
19	positive regulation of prostaglandin secretion (GO:0032308)	3.80630492
20	ubiquinone metabolic process (GO:0006743)	3.75282737
21	cellular biogenic amine catabolic process (GO:0042402)	3.67750856
22	amine catabolic process (GO:0009310)	3.67750856
23	adaptation of signaling pathway (GO:0023058)	3.61210543
24	G-protein coupled receptor internalization (GO:0002031)	3.51232519
25	mitochondrial respiratory chain complex assembly (GO:0033108)	3.46248671
26	protein refolding (GO:0042026)	3.42633791
27	cytidine deamination (GO:0009972)	3.42323157
28	cytidine metabolic process (GO:0046087)	3.42323157
29	cytidine catabolic process (GO:0006216)	3.42323157
30	quinone biosynthetic process (GO:1901663)	3.41680391
31	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	3.38889334
32	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	3.38889334
33	mannosylation (GO:0097502)	3.38798474
34	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.35284180
35	regulation of autophagic vacuole assembly (GO:2000785)	3.30110786
36	preassembly of GPI anchor in ER membrane (GO:0016254)	3.27924141
37	peptidyl-histidine modification (GO:0018202)	3.26256608
38	retinal cone cell development (GO:0046549)	3.25050708
39	proteasome assembly (GO:0043248)	3.24489844
40	positive regulation of fatty acid transport (GO:2000193)	3.24318832
41	artery development (GO:0060840)	3.24271912
42	respiratory electron transport chain (GO:0022904)	3.23655466
43	electron transport chain (GO:0022900)	3.22311264
44	negative regulation of mast cell activation (GO:0033004)	3.21674443
45	arginine catabolic process (GO:0006527)	3.15165917
46	regulation of prostaglandin secretion (GO:0032306)	3.14338310
47	cranial nerve structural organization (GO:0021604)	3.12096285
48	intracellular protein transmembrane import (GO:0044743)	3.11904025
49	mitotic sister chromatid segregation (GO:0000070)	3.11243527
50	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.10667738
51	response to interferon-beta (GO:0035456)	3.09011656
52	protein polyglutamylation (GO:0018095)	3.03802772
53	oxygen transport (GO:0015671)	3.03331899
54	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.02094996
55	positive regulation of protein homooligomerization (GO:0032464)	3.00356773
56	chaperone-mediated protein transport (GO:0072321)	3.00053021
57	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.99526595
58	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.98822147
59	polyamine metabolic process (GO:0006595)	2.98364269
60	positive regulation of icosanoid secretion (GO:0032305)	2.95998120
61	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	2.93485515
62	cellular biogenic amine biosynthetic process (GO:0042401)	2.91053993
63	DNA damage response, detection of DNA damage (GO:0042769)	2.89159530
64	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.88845480
65	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.88845480
66	response to misfolded protein (GO:0051788)	2.88585219
67	icosanoid secretion (GO:0032309)	2.87693768
68	arachidonic acid secretion (GO:0050482)	2.87693768
69	cellular response to interferon-beta (GO:0035458)	2.86859109
70	response to dietary excess (GO:0002021)	2.85618346
71	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.83383188
72	synaptic transmission, dopaminergic (GO:0001963)	2.83063421
73	regulation of MHC class I biosynthetic process (GO:0045343)	2.82105530
74	regulation of hippo signaling (GO:0035330)	2.81710190
75	protein-cofactor linkage (GO:0018065)	2.81265565
76	outer ear morphogenesis (GO:0042473)	2.81033474
77	regulation of proton transport (GO:0010155)	2.78411388
78	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.77214655
79	L-phenylalanine catabolic process (GO:0006559)	2.77214655
80	regulation of synaptic transmission, dopaminergic (GO:0032225)	2.74562612
81	platelet dense granule organization (GO:0060155)	2.73708641
82	cellular response to ATP (GO:0071318)	2.72436105
83	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.72301445
84	axoneme assembly (GO:0035082)	2.72004888
85	piRNA metabolic process (GO:0034587)	2.71720439
86	protein K6-linked ubiquitination (GO:0085020)	2.71346029
87	DNA catabolic process, exonucleolytic (GO:0000738)	2.71238292
88	ribosomal small subunit assembly (GO:0000028)	2.71178520
89	amine biosynthetic process (GO:0009309)	2.70464453
90	endoderm formation (GO:0001706)	2.68774640
91	regulation of neurotransmitter uptake (GO:0051580)	2.67014740
92	cytochrome complex assembly (GO:0017004)	2.65979757
93	response to amphetamine (GO:0001975)	2.64346590
94	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.63014828
95	regulation of vacuole organization (GO:0044088)	2.62781642
96	cornea development in camera-type eye (GO:0061303)	2.56538937
97	signal peptide processing (GO:0006465)	2.56321312
98	pyrimidine nucleotide catabolic process (GO:0006244)	2.55947313
99	purine deoxyribonucleotide catabolic process (GO:0009155)	2.54227793
100	prepulse inhibition (GO:0060134)	2.53591124

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.16256309
2	VDR_22108803_ChIP-Seq_LS180_Human	4.11447574
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.67527319
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.28010831
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.09568711
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.94116680
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.80910405
8	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.78935598
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.65384833
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.61839346
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.59916842
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.53888960
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.44310020
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.35555867
15	GATA3_21878914_ChIP-Seq_MCF-7_Human	2.20563255
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.20516689
17	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.11914931
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.10055827
19	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.02532183
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.90783770
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.89797426
22	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.83709000
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.81978411
24	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.80751741
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.76098859
26	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.75127634
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71205099
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.70451049
29	EWS_26573619_Chip-Seq_HEK293_Human	1.67309566
30	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.65022777
31	NANOG_19829295_ChIP-Seq_ESCs_Human	1.61886963
32	SOX2_19829295_ChIP-Seq_ESCs_Human	1.61886963
33	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.60060618
34	GATA3_26560356_Chip-Seq_TH2_Human	1.56109931
35	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.54663156
36	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.52253042
37	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.52176502
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.52176502
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.51857715
40	ERA_21632823_ChIP-Seq_H3396_Human	1.51580069
41	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.47879441
42	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.46023071
43	TAF2_19829295_ChIP-Seq_ESCs_Human	1.44858152
44	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.44743355
45	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.40926923
46	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.40552201
47	HOXB7_26014856_ChIP-Seq_BT474_Human	1.39022025
48	NANOG_20526341_ChIP-Seq_ESCs_Human	1.37874365
49	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.34638217
50	NCOR_22424771_ChIP-Seq_293T_Human	1.34193993
51	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.33138349
52	CTCF_20526341_ChIP-Seq_ESCs_Human	1.31075605
53	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.30492012
54	MYC_19829295_ChIP-Seq_ESCs_Human	1.29024350
55	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.28673617
56	FOXP3_21729870_ChIP-Seq_TREG_Human	1.27966709
57	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.25841870
58	GABP_19822575_ChIP-Seq_HepG2_Human	1.25347022
59	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.23913479
60	ELK1_19687146_ChIP-ChIP_HELA_Human	1.22231761
61	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.21220638
62	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.20697022
63	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.14968107
64	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.14190789
65	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.12321114
66	ZNF263_19887448_ChIP-Seq_K562_Human	1.11723448
67	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.10945083
68	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10013072
69	ER_23166858_ChIP-Seq_MCF-7_Human	1.09876791
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.09756759
71	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.09178870
72	REST_21632747_ChIP-Seq_MESCs_Mouse	1.09081393
73	GATA3_26560356_Chip-Seq_TH1_Human	1.07382349
74	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.06814245
75	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.06527275
76	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.06134524
77	P53_21459846_ChIP-Seq_SAOS-2_Human	1.05665293
78	AR_20517297_ChIP-Seq_VCAP_Human	1.04251394
79	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.03060752
80	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.03023517
81	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.02788605
82	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.02175531
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99471552
84	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.98523525
85	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98401389
86	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97934788
87	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.95704541
88	SMRT_27268052_Chip-Seq_Bcells_Human	0.94122394
89	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93731801
90	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.93498920
91	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.92905138
92	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.92746819
93	AR_21572438_ChIP-Seq_LNCaP_Human	0.90536341
94	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.90404146
95	BCAT_22108803_ChIP-Seq_LS180_Human	0.89394893
96	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.88498687
97	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.88277389
98	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87957086
99	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87586628
100	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.87526752

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005451_abnormal_body_composition	3.79196604
2	MP0009046_muscle_twitch	2.92177232
3	MP0004885_abnormal_endolymph	2.85287157
4	MP0003693_abnormal_embryo_hatching	2.81305956
5	MP0008872_abnormal_physiological_respon	2.80788415
6	MP0008875_abnormal_xenobiotic_pharmacok	2.79661418
7	MP0000372_irregular_coat_pigmentation	2.73366614
8	MP0006292_abnormal_olfactory_placode	2.50491012
9	MP0002653_abnormal_ependyma_morphology	2.29174415
10	MP0002735_abnormal_chemical_nociception	2.16294956
11	MP0002736_abnormal_nociception_after	2.15305367
12	MP0000678_abnormal_parathyroid_gland	2.02654241
13	MP0001968_abnormal_touch/_nociception	2.00164529
14	MP0004145_abnormal_muscle_electrophysio	1.99825968
15	MP0005410_abnormal_fertilization	1.99064439
16	MP0004147_increased_porphyrin_level	1.98691502
17	MP0008007_abnormal_cellular_replicative	1.96877530
18	MP0005075_abnormal_melanosome_morpholog	1.95740492
19	MP0005671_abnormal_response_to	1.93178996
20	MP0001486_abnormal_startle_reflex	1.89987820
21	MP0001905_abnormal_dopamine_level	1.87165529
22	MP0002163_abnormal_gland_morphology	1.84585362
23	MP0002638_abnormal_pupillary_reflex	1.80731150
24	MP0000569_abnormal_digit_pigmentation	1.80409030
25	MP0003011_delayed_dark_adaptation	1.78764686
26	MP0005551_abnormal_eye_electrophysiolog	1.70562755
27	MP0002095_abnormal_skin_pigmentation	1.70543416
28	MP0005377_hearing/vestibular/ear_phenot	1.70020304
29	MP0003878_abnormal_ear_physiology	1.70020304
30	MP0002160_abnormal_reproductive_system	1.68467045
31	MP0006072_abnormal_retinal_apoptosis	1.67621111
32	MP0000647_abnormal_sebaceous_gland	1.65882364
33	MP0002733_abnormal_thermal_nociception	1.56856641
34	MP0002837_dystrophic_cardiac_calcinosis	1.54884859
35	MP0001440_abnormal_grooming_behavior	1.50746943
36	MP0000015_abnormal_ear_pigmentation	1.47269669
37	MP0001970_abnormal_pain_threshold	1.44421546
38	MP0006276_abnormal_autonomic_nervous	1.39951465
39	MP0003646_muscle_fatigue	1.39764692
40	MP0009745_abnormal_behavioral_response	1.39700596
41	MP0008877_abnormal_DNA_methylation	1.37298003
42	MP0004742_abnormal_vestibular_system	1.36651056
43	MP0002277_abnormal_respiratory_mucosa	1.36504379
44	MP0009765_abnormal_xenobiotic_induced	1.34970378
45	MP0000427_abnormal_hair_cycle	1.34189814
46	MP0003806_abnormal_nucleotide_metabolis	1.33552617
47	MP0005389_reproductive_system_phenotype	1.29189067
48	MP0001188_hyperpigmentation	1.27149526
49	MP0003786_premature_aging	1.23910989
50	MP0001501_abnormal_sleep_pattern	1.21501443
51	MP0003718_maternal_effect	1.19822186
52	MP0005408_hypopigmentation	1.17951035
53	MP0005253_abnormal_eye_physiology	1.17550126
54	MP0001986_abnormal_taste_sensitivity	1.15438195
55	MP0008789_abnormal_olfactory_epithelium	1.14733503
56	MP0001502_abnormal_circadian_rhythm	1.13977140
57	MP0004142_abnormal_muscle_tone	1.10232404
58	MP0002148_abnormal_hypersensitivity_rea	1.09521835
59	MP0005379_endocrine/exocrine_gland_phen	1.00190625
60	MP0002272_abnormal_nervous_system	0.98026496
61	MP0003950_abnormal_plasma_membrane	0.96906958
62	MP0009764_decreased_sensitivity_to	0.96893354
63	MP0000631_abnormal_neuroendocrine_gland	0.96288106
64	MP0005645_abnormal_hypothalamus_physiol	0.96178655
65	MP0002067_abnormal_sensory_capabilities	0.93075936
66	MP0003186_abnormal_redox_activity	0.91480686
67	MP0001984_abnormal_olfaction	0.91351897
68	MP0009785_altered_susceptibility_to	0.89974459
69	MP0002572_abnormal_emotion/affect_behav	0.89790300
70	MP0003195_calcinosis	0.89592010
71	MP0002132_abnormal_respiratory_system	0.87845164
72	MP0002557_abnormal_social/conspecific_i	0.87107746
73	MP0001929_abnormal_gametogenesis	0.85786124
74	MP0006036_abnormal_mitochondrial_physio	0.85373330
75	MP0000230_abnormal_systemic_arterial	0.84805565
76	MP0003635_abnormal_synaptic_transmissio	0.82045775
77	MP0003787_abnormal_imprinting	0.81920614
78	MP0002064_seizures	0.81617566
79	MP0008775_abnormal_heart_ventricle	0.81614636
80	MP0005423_abnormal_somatic_nervous	0.81082211
81	MP0002210_abnormal_sex_determination	0.80366129
82	MP0003638_abnormal_response/metabolism_	0.79753556
83	MP0008995_early_reproductive_senescence	0.78694109
84	MP0001919_abnormal_reproductive_system	0.76682048
85	MP0000049_abnormal_middle_ear	0.75837423
86	MP0005646_abnormal_pituitary_gland	0.75042924
87	MP0003698_abnormal_male_reproductive	0.74807100
88	MP0000604_amyloidosis	0.74270967
89	MP0002876_abnormal_thyroid_physiology	0.73785106
90	MP0002166_altered_tumor_susceptibility	0.73115681
91	MP0002938_white_spotting	0.72818696
92	MP0003136_yellow_coat_color	0.72546681
93	MP0004133_heterotaxia	0.71762189
94	MP0002063_abnormal_learning/memory/cond	0.71552772
95	MP0005670_abnormal_white_adipose	0.70022647
96	MP0004134_abnormal_chest_morphology	0.67466459
97	MP0004381_abnormal_hair_follicle	0.67451664
98	MP0000653_abnormal_sex_gland	0.65708074
99	MP0010094_abnormal_chromosome_stability	0.65012062
100	MP0002006_tumorigenesis	0.64296580

Predicted human phenotypes

Rank	Gene Set	Z-score
1	11 pairs of ribs (HP:0000878)	4.76540548
2	Molar tooth sign on MRI (HP:0002419)	4.42820943
3	Abnormality of midbrain morphology (HP:0002418)	4.42820943
4	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.16314775
5	Abnormality of alanine metabolism (HP:0010916)	4.16314775
6	Hyperalaninemia (HP:0003348)	4.16314775
7	Pancreatic cysts (HP:0001737)	3.97705704
8	True hermaphroditism (HP:0010459)	3.65007796
9	Broad distal phalanx of finger (HP:0009836)	3.59453142
10	Conical tooth (HP:0000698)	3.59234999
11	Pancreatic fibrosis (HP:0100732)	3.46378210
12	Large for gestational age (HP:0001520)	3.12881859
13	Pendular nystagmus (HP:0012043)	3.01181911
14	Mitochondrial inheritance (HP:0001427)	2.94925709
15	Renal Fanconi syndrome (HP:0001994)	2.94814548
16	Acute necrotizing encephalopathy (HP:0006965)	2.90886980
17	Abnormal mitochondria in muscle tissue (HP:0008316)	2.88220317
18	Progressive microcephaly (HP:0000253)	2.83271018
19	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.82269071
20	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.82269071
21	Hepatocellular necrosis (HP:0001404)	2.80034938
22	Increased CSF lactate (HP:0002490)	2.78720816
23	Radial bowing (HP:0002986)	2.77281592
24	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.74694796
25	Short nail (HP:0001799)	2.71952304
26	3-Methylglutaconic aciduria (HP:0003535)	2.71891903
27	Stomach cancer (HP:0012126)	2.70176754
28	Congenital, generalized hypertrichosis (HP:0004540)	2.64138218
29	Congenital stationary night blindness (HP:0007642)	2.64005423
30	Cystic liver disease (HP:0006706)	2.63759583
31	Hypoplasia of the uterus (HP:0000013)	2.60209304
32	Hepatic necrosis (HP:0002605)	2.60123092
33	Acute encephalopathy (HP:0006846)	2.55781716
34	Type II lissencephaly (HP:0007260)	2.51424542
35	Nephronophthisis (HP:0000090)	2.43817759
36	Microretrognathia (HP:0000308)	2.40144244
37	Duplicated collecting system (HP:0000081)	2.39074741
38	Increased intramyocellular lipid droplets (HP:0012240)	2.38025887
39	Increased serum lactate (HP:0002151)	2.36941256
40	Abnormality of the renal collecting system (HP:0004742)	2.34582114
41	Flared iliac wings (HP:0002869)	2.33983900
42	Cerebral hypomyelination (HP:0006808)	2.30860703
43	Furrowed tongue (HP:0000221)	2.29277290
44	Stomatitis (HP:0010280)	2.27141748
45	Aplasia/hypoplasia of the uterus (HP:0008684)	2.26837066
46	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.25534901
47	Chronic hepatic failure (HP:0100626)	2.23368446
48	Abnormal hemoglobin (HP:0011902)	2.21024702
49	Elevated erythrocyte sedimentation rate (HP:0003565)	2.19262704
50	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.18251267
51	Progressive macrocephaly (HP:0004481)	2.17196519
52	Decreased central vision (HP:0007663)	2.14619152
53	Lipid accumulation in hepatocytes (HP:0006561)	2.13960172
54	Irregular vertebral endplates (HP:0003301)	2.13186182
55	Increased hepatocellular lipid droplets (HP:0006565)	2.11509151
56	Sclerocornea (HP:0000647)	2.11500506
57	Spinal cord compression (HP:0002176)	2.10263166
58	X-linked dominant inheritance (HP:0001423)	2.10217193
59	Anencephaly (HP:0002323)	2.08314041
60	Abnormality of renal resorption (HP:0011038)	2.08258582
61	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.04980434
62	IgG deficiency (HP:0004315)	2.04075732
63	Broad alveolar ridges (HP:0000187)	2.03197519
64	Increased muscle lipid content (HP:0009058)	2.02646251
65	Delayed CNS myelination (HP:0002188)	2.01827601
66	Median cleft lip (HP:0000161)	2.00975288
67	Male pseudohermaphroditism (HP:0000037)	2.00965163
68	Ileus (HP:0002595)	1.99242819
69	Abnormality of the renal medulla (HP:0100957)	1.97165678
70	Myokymia (HP:0002411)	1.95608475
71	Concave nail (HP:0001598)	1.95282307
72	Abnormal rod and cone electroretinograms (HP:0008323)	1.94788466
73	Oculomotor apraxia (HP:0000657)	1.91069904
74	Limb dystonia (HP:0002451)	1.90741174
75	Abnormality of lateral ventricle (HP:0030047)	1.89865496
76	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.89047436
77	Lactic acidosis (HP:0003128)	1.88035140
78	Progressive cerebellar ataxia (HP:0002073)	1.85324976
79	Hyperventilation (HP:0002883)	1.83991764
80	Pancreatic islet-cell hyperplasia (HP:0004510)	1.82843691
81	Constricted visual fields (HP:0001133)	1.82344576
82	Increased IgM level (HP:0003496)	1.82095911
83	Breast hypoplasia (HP:0003187)	1.80905306
84	Nonprogressive disorder (HP:0003680)	1.80509589
85	Ectopic kidney (HP:0000086)	1.79014715
86	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.78372590
87	Short femoral neck (HP:0100864)	1.76848141
88	Inability to walk (HP:0002540)	1.76203850
89	Supernumerary bones of the axial skeleton (HP:0009144)	1.75797607
90	Partial agenesis of the corpus callosum (HP:0001338)	1.75306448
91	Broad-based gait (HP:0002136)	1.74523332
92	Methylmalonic acidemia (HP:0002912)	1.74119630
93	Occipital encephalocele (HP:0002085)	1.73372918
94	Abnormality of the renal cortex (HP:0011035)	1.73274865
95	Absent eyebrow (HP:0002223)	1.72223404
96	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.71899396
97	Medial flaring of the eyebrow (HP:0010747)	1.71033662
98	Abnormal finger flexion creases (HP:0006143)	1.70535515
99	Fair hair (HP:0002286)	1.70529179
100	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.70050980

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MUSK	4.76233142
2	MAP4K2	3.59721033
3	AKT3	3.53971195
4	BCKDK	3.47225197
5	MAPKAPK5	3.30248538
6	TRIM28	3.18548199
7	GRK1	3.17508261
8	PDK2	3.13856171
9	NUAK1	2.89303496
10	TIE1	2.79675250
11	PINK1	2.79010696
12	TLK1	2.73101128
13	ADRBK2	2.59648896
14	NTRK3	1.94590986
15	ZAK	1.76544145
16	NEK1	1.74881008
17	EPHA3	1.69826776
18	BMPR1B	1.60433555
19	GRK5	1.59631623
20	KDR	1.59299339
21	MAP3K2	1.58640174
22	DYRK2	1.51847888
23	IKBKB	1.45459010
24	BRAF	1.38386199
25	PLK4	1.26140494
26	WNK3	1.24647256
27	PNCK	1.11849880
28	WNK4	1.07666835
29	MAP3K13	1.02079020
30	VRK1	1.01602402
31	ACVR1B	0.98630852
32	KSR1	0.97766515
33	VRK2	0.92333487
34	PIK3CA	0.89850660
35	EIF2AK3	0.87302799
36	FRK	0.84410485
37	MARK3	0.83555882
38	MAPK13	0.81593145
39	MAP3K9	0.81024271
40	PKN1	0.80807143
41	BRSK2	0.79926340
42	MARK1	0.78440063
43	MAP2K2	0.78288797
44	MAPKAPK3	0.73887308
45	TEC	0.73174988
46	NTRK1	0.72433713
47	EIF2AK2	0.72426182
48	PHKG2	0.70598122
49	PHKG1	0.70598122
50	RAF1	0.68540400
51	KSR2	0.68362264
52	BUB1	0.68345602
53	WEE1	0.66643605
54	NEK6	0.65986705
55	OXSR1	0.65450692
56	PRKCG	0.65057285
57	INSRR	0.64753411
58	PRKD3	0.62828512
59	TGFBR1	0.60709106
60	MAP2K1	0.59344556
61	ATR	0.59341459
62	RPS6KA5	0.54982652
63	CHUK	0.54505206
64	MKNK2	0.53128329
65	CAMKK2	0.51260940
66	PRKCI	0.50132736
67	MAP3K3	0.49315929
68	ADRBK1	0.46977370
69	MAP3K12	0.46371846
70	SGK2	0.45593649
71	PAK1	0.45564247
72	WNK1	0.45496566
73	TXK	0.45209975
74	DAPK2	0.45090316
75	CDK4	0.44794304
76	AURKA	0.44032846
77	BRSK1	0.43931847
78	FER	0.43900136
79	ARAF	0.42558444
80	PAK3	0.40813513
81	PRKCQ	0.40678085
82	PLK2	0.40551496
83	MAP3K4	0.39807031
84	SGK223	0.37928507
85	SGK494	0.37928507
86	ABL2	0.37361108
87	TSSK6	0.36090339
88	DAPK1	0.35803225
89	CSNK1G3	0.35709782
90	GRK6	0.35686580
91	IKBKE	0.34861800
92	TNIK	0.32542500
93	MATK	0.32268694
94	GSK3A	0.31326818
95	ITK	0.30948352
96	CAMK1	0.30375109
97	RPS6KA1	0.29685889
98	PLK3	0.28736282
99	NEK2	0.28009447
100	MAPK15	0.26661958

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.77659263
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.65276113
3	Selenocompound metabolism_Homo sapiens_hsa00450	3.41561738
4	Parkinsons disease_Homo sapiens_hsa05012	3.38859652
5	Proteasome_Homo sapiens_hsa03050	2.90627449
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.60547734
7	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.47546528
8	Protein export_Homo sapiens_hsa03060	2.31621816
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.30696678
10	Huntingtons disease_Homo sapiens_hsa05016	2.00323029
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.95499382
12	Alzheimers disease_Homo sapiens_hsa05010	1.92236416
13	Butanoate metabolism_Homo sapiens_hsa00650	1.87778207
14	Ribosome_Homo sapiens_hsa03010	1.86329381
15	RNA polymerase_Homo sapiens_hsa03020	1.85973796
16	Cardiac muscle contraction_Homo sapiens_hsa04260	1.85614482
17	Primary immunodeficiency_Homo sapiens_hsa05340	1.78879073
18	Fatty acid elongation_Homo sapiens_hsa00062	1.76870331
19	Sulfur metabolism_Homo sapiens_hsa00920	1.76372584
20	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.71322257
21	Phototransduction_Homo sapiens_hsa04744	1.69586394
22	Regulation of autophagy_Homo sapiens_hsa04140	1.64259629
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.61390707
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.61177590
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.54318016
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.53034441
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.52925886
28	Propanoate metabolism_Homo sapiens_hsa00640	1.43192206
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.42648156
30	Homologous recombination_Homo sapiens_hsa03440	1.39408539
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.34965349
32	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.33431691
33	Peroxisome_Homo sapiens_hsa04146	1.28475672
34	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.24367859
35	Steroid biosynthesis_Homo sapiens_hsa00100	1.23090065
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.22795863
37	Nicotine addiction_Homo sapiens_hsa05033	1.22646953
38	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.22370922
39	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.17503730
40	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.14855074
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.13015879
42	Fanconi anemia pathway_Homo sapiens_hsa03460	1.11474765
43	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.10655179
44	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.07872635
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.05333686
46	Caffeine metabolism_Homo sapiens_hsa00232	1.04493222
47	Ether lipid metabolism_Homo sapiens_hsa00565	1.02303646
48	Tyrosine metabolism_Homo sapiens_hsa00350	0.95107450
49	Fat digestion and absorption_Homo sapiens_hsa04975	0.93388670
50	Sulfur relay system_Homo sapiens_hsa04122	0.93125369
51	Antigen processing and presentation_Homo sapiens_hsa04612	0.89633238
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.85435680
53	RNA degradation_Homo sapiens_hsa03018	0.81084172
54	Morphine addiction_Homo sapiens_hsa05032	0.79226679
55	Pyrimidine metabolism_Homo sapiens_hsa00240	0.78163831
56	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.72016368
57	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.67125372
58	Olfactory transduction_Homo sapiens_hsa04740	0.67040821
59	Metabolic pathways_Homo sapiens_hsa01100	0.66926632
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66777091
61	Retinol metabolism_Homo sapiens_hsa00830	0.66139600
62	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.65656681
63	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.63917150
64	Basal transcription factors_Homo sapiens_hsa03022	0.63097841
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61932674
66	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.60232026
67	Purine metabolism_Homo sapiens_hsa00230	0.60009521
68	Mineral absorption_Homo sapiens_hsa04978	0.57476779
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.56745605
70	Spliceosome_Homo sapiens_hsa03040	0.55680297
71	Circadian rhythm_Homo sapiens_hsa04710	0.51749625
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48597008
73	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.45921310
74	Glutathione metabolism_Homo sapiens_hsa00480	0.45268985
75	Taste transduction_Homo sapiens_hsa04742	0.44330841
76	Fatty acid metabolism_Homo sapiens_hsa01212	0.43284556
77	One carbon pool by folate_Homo sapiens_hsa00670	0.42250447
78	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.41355479
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.41322891
80	Asthma_Homo sapiens_hsa05310	0.40255179
81	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.39879532
82	RNA transport_Homo sapiens_hsa03013	0.39486037
83	Allograft rejection_Homo sapiens_hsa05330	0.37995168
84	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.37705076
85	Other glycan degradation_Homo sapiens_hsa00511	0.36991655
86	Tryptophan metabolism_Homo sapiens_hsa00380	0.36439047
87	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.32504080
88	Circadian entrainment_Homo sapiens_hsa04713	0.32259372
89	Phenylalanine metabolism_Homo sapiens_hsa00360	0.31317509
90	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.30887406
91	Legionellosis_Homo sapiens_hsa05134	0.30184193
92	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.30068352
93	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.28681619
94	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.27573268
95	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.27322432
96	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.26733193
97	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.26206945
98	Base excision repair_Homo sapiens_hsa03410	0.25664782
99	Salivary secretion_Homo sapiens_hsa04970	0.24090813
100	Measles_Homo sapiens_hsa05162	0.22827606

RPS26P43

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »