ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of somitogenesis (GO:0014807)	9.87152281
2	behavioral response to nicotine (GO:0035095)	6.12174312
3	response to pheromone (GO:0019236)	5.45116479
4	cellular ketone body metabolic process (GO:0046950)	5.37595598
5	acrosome reaction (GO:0007340)	5.33278664
6	maturation of 5.8S rRNA (GO:0000460)	5.31127691
7	fusion of sperm to egg plasma membrane (GO:0007342)	5.28094517
8	regulation of isotype switching to IgG isotypes (GO:0048302)	5.21901493
9	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	5.18431119
10	sperm motility (GO:0030317)	5.09787256
11	ketone body metabolic process (GO:1902224)	4.73908330
12	ribosomal large subunit biogenesis (GO:0042273)	4.69490465
13	positive regulation of triglyceride biosynthetic process (GO:0010867)	4.67219067
14	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	4.58104119
15	regulation of immunoglobulin secretion (GO:0051023)	4.44607000
16	positive regulation of embryonic development (GO:0040019)	4.42179951
17	plasma membrane fusion (GO:0045026)	4.36821002
18	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.26074089
19	protein polyglutamylation (GO:0018095)	4.17449971
20	multicellular organism reproduction (GO:0032504)	3.94025405
21	microtubule depolymerization (GO:0007019)	3.81560883
22	maturation of SSU-rRNA (GO:0030490)	3.81280165
23	calcium ion-dependent exocytosis (GO:0017156)	3.69605855
24	C4-dicarboxylate transport (GO:0015740)	3.64276499
25	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.61005183
26	sperm-egg recognition (GO:0035036)	3.58854853
27	positive regulation of action potential (GO:0045760)	3.55605395
28	negative regulation of mast cell activation (GO:0033004)	3.52224532
29	endoderm formation (GO:0001706)	3.51777877
30	alanine transport (GO:0032328)	3.41233109
31	regulation of triglyceride biosynthetic process (GO:0010866)	3.39819389
32	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.34339942
33	interferon-gamma production (GO:0032609)	3.24733011
34	peristalsis (GO:0030432)	3.24605698
35	adaptation of signaling pathway (GO:0023058)	3.22860436
36	chaperone-mediated protein transport (GO:0072321)	3.20484329
37	rRNA catabolic process (GO:0016075)	3.19341393
38	basic amino acid transport (GO:0015802)	3.16397234
39	regulation of action potential (GO:0098900)	3.14129260
40	mast cell activation involved in immune response (GO:0002279)	3.11600157
41	mast cell degranulation (GO:0043303)	3.11600157
42	positive regulation of gastrulation (GO:2000543)	3.10124262
43	protein-cofactor linkage (GO:0018065)	3.09557459
44	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.08740487
45	regulation of mitotic spindle checkpoint (GO:1903504)	3.08740487
46	male meiosis I (GO:0007141)	3.07983666
47	DNA methylation involved in gamete generation (GO:0043046)	3.07675014
48	cell-cell recognition (GO:0009988)	3.07092890
49	ubiquinone biosynthetic process (GO:0006744)	3.05102669
50	ubiquinone metabolic process (GO:0006743)	3.04285339
51	DNA deamination (GO:0045006)	3.01889188
52	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.01336469
53	reproduction (GO:0000003)	3.01081243
54	protein prenylation (GO:0018342)	2.98302566
55	prenylation (GO:0097354)	2.98302566
56	chaperone-mediated protein complex assembly (GO:0051131)	2.95614952
57	cerebral cortex neuron differentiation (GO:0021895)	2.92792073
58	gamma-aminobutyric acid transport (GO:0015812)	2.89382378
59	piRNA metabolic process (GO:0034587)	2.87245923
60	sperm capacitation (GO:0048240)	2.85437520
61	neuron fate determination (GO:0048664)	2.85404400
62	synaptic transmission, cholinergic (GO:0007271)	2.81821776
63	binding of sperm to zona pellucida (GO:0007339)	2.80661853
64	positive regulation of isotype switching (GO:0045830)	2.77705828
65	reciprocal meiotic recombination (GO:0007131)	2.72872157
66	reciprocal DNA recombination (GO:0035825)	2.72872157
67	positive regulation of DNA recombination (GO:0045911)	2.72141152
68	dopaminergic neuron differentiation (GO:0071542)	2.69978018
69	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.68144961
70	neuromuscular synaptic transmission (GO:0007274)	2.67078576
71	regulation of regulatory T cell differentiation (GO:0045589)	2.65965035
72	cellular response to pH (GO:0071467)	2.65049542
73	somite development (GO:0061053)	2.62597352
74	polyamine metabolic process (GO:0006595)	2.62212810
75	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.61344841
76	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.61344841
77	positive regulation of triglyceride metabolic process (GO:0090208)	2.59155393
78	protein K11-linked deubiquitination (GO:0035871)	2.58793034
79	pyrimidine nucleobase catabolic process (GO:0006208)	2.58504651
80	myoblast migration (GO:0051451)	2.58185718
81	meiosis I (GO:0007127)	2.52940993
82	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.51973642
83	spermatogenesis (GO:0007283)	2.48528436
84	male gamete generation (GO:0048232)	2.48255927
85	nephron tubule morphogenesis (GO:0072078)	2.47907950
86	nephron epithelium morphogenesis (GO:0072088)	2.47907950
87	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.47368993
88	seminiferous tubule development (GO:0072520)	2.44159910
89	amine catabolic process (GO:0009310)	2.43937892
90	cellular biogenic amine catabolic process (GO:0042402)	2.43937892
91	arginine catabolic process (GO:0006527)	2.42334730
92	regulation of cilium movement (GO:0003352)	2.42221339
93	spermatid development (GO:0007286)	2.40467144
94	quinone biosynthetic process (GO:1901663)	2.37769168
95	microtubule polymerization or depolymerization (GO:0031109)	2.36902713
96	intracellular protein transmembrane import (GO:0044743)	2.35708912
97	axonemal dynein complex assembly (GO:0070286)	2.35604794
98	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.34764169
99	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.34282907
100	protein targeting to Golgi (GO:0000042)	2.32357583

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.54435852
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.45423229
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.19286736
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.04729208
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.72459161
6	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.38668755
7	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.28303201
8	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.06771650
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.99995807
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.93349629
11	ERA_21632823_ChIP-Seq_H3396_Human	1.85658206
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.84341468
13	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.80942131
14	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.80022503
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.76986117
16	MYC_18940864_ChIP-ChIP_HL60_Human	1.74302854
17	VDR_22108803_ChIP-Seq_LS180_Human	1.72552742
18	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.70173048
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.65135051
20	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.63694079
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.62755122
22	FUS_26573619_Chip-Seq_HEK293_Human	1.62746214
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.59939216
24	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.59321773
25	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.58572166
26	REST_21632747_ChIP-Seq_MESCs_Mouse	1.56060356
27	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.52580691
28	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.52378939
29	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.48600381
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47527762
31	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.45541532
32	TAF2_19829295_ChIP-Seq_ESCs_Human	1.44546942
33	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.44315429
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43504715
35	TAF15_26573619_Chip-Seq_HEK293_Human	1.42275532
36	P300_19829295_ChIP-Seq_ESCs_Human	1.41759934
37	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.41732008
38	RAC3_21632823_ChIP-Seq_H3396_Human	1.41630430
39	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.40840544
40	GBX2_23144817_ChIP-Seq_PC3_Human	1.40823597
41	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.38899276
42	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.37768479
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37768479
44	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.36411241
45	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.35178382
46	MYC_19829295_ChIP-Seq_ESCs_Human	1.34383974
47	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.34224903
48	NCOR_22424771_ChIP-Seq_293T_Human	1.33113993
49	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.31900029
50	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.31847900
51	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.29191701
52	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.26281731
53	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.25590181
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.25102829
55	PHF8_20622854_ChIP-Seq_HELA_Human	1.24099825
56	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.22430300
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21456291
58	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21456291
59	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.19631501
60	P53_21459846_ChIP-Seq_SAOS-2_Human	1.16798904
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16373970
62	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.16007018
63	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.15939417
64	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.15272687
65	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.14824117
66	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.13634853
67	IRF1_19129219_ChIP-ChIP_H3396_Human	1.13362795
68	CTCF_20526341_ChIP-Seq_ESCs_Human	1.13316378
69	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.12955484
70	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.12955484
71	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.12920681
72	EWS_26573619_Chip-Seq_HEK293_Human	1.12839624
73	E2F1_20622854_ChIP-Seq_HELA_Human	1.12292532
74	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.12067394
75	CBP_20019798_ChIP-Seq_JUKART_Human	1.12067394
76	NANOG_20526341_ChIP-Seq_ESCs_Human	1.09988151
77	OCT4_20526341_ChIP-Seq_ESCs_Human	1.09078380
78	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08979651
79	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.07806634
80	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.06626684
81	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.04850933
82	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.03967360
83	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.03438106
84	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.02566808
85	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02087217
86	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.01345844
87	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.98893965
88	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98711312
89	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.97945962
90	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97842139
91	TCF4_22108803_ChIP-Seq_LS180_Human	0.97750345
92	NANOG_19829295_ChIP-Seq_ESCs_Human	0.94938949
93	SOX2_19829295_ChIP-Seq_ESCs_Human	0.94938949
94	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.94598067
95	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.94322808
96	TP53_22573176_ChIP-Seq_HFKS_Human	0.94263542
97	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.94068699
98	BCL6_27268052_Chip-Seq_Bcells_Human	0.93593184
99	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.93214243
100	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.92877199

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	3.80486449
2	MP0003646_muscle_fatigue	2.99032125
3	MP0003011_delayed_dark_adaptation	2.86669110
4	MP0003879_abnormal_hair_cell	2.72293618
5	MP0001905_abnormal_dopamine_level	2.56213963
6	MP0001529_abnormal_vocalization	2.48867181
7	MP0002102_abnormal_ear_morphology	2.32562121
8	MP0002876_abnormal_thyroid_physiology	2.32519209
9	MP0002234_abnormal_pharynx_morphology	2.29639380
10	MP0001986_abnormal_taste_sensitivity	2.21740543
11	MP0003283_abnormal_digestive_organ	2.21622301
12	MP0002735_abnormal_chemical_nociception	2.10422541
13	MP0008789_abnormal_olfactory_epithelium	2.02975733
14	MP0005084_abnormal_gallbladder_morpholo	2.02406300
15	MP0006292_abnormal_olfactory_placode	1.93877772
16	MP0002837_dystrophic_cardiac_calcinosis	1.88478526
17	MP0001727_abnormal_embryo_implantation	1.84983381
18	MP0006276_abnormal_autonomic_nervous	1.84831874
19	MP0002277_abnormal_respiratory_mucosa	1.82006716
20	MP0001177_atelectasis	1.78910956
21	MP0003878_abnormal_ear_physiology	1.77324872
22	MP0005377_hearing/vestibular/ear_phenot	1.77324872
23	MP0001853_heart_inflammation	1.71816797
24	MP0008875_abnormal_xenobiotic_pharmacok	1.70815846
25	MP0004142_abnormal_muscle_tone	1.68186518
26	MP0001348_abnormal_lacrimal_gland	1.64178673
27	MP0005423_abnormal_somatic_nervous	1.64087548
28	MP0003693_abnormal_embryo_hatching	1.63988719
29	MP0009745_abnormal_behavioral_response	1.63820163
30	MP0002272_abnormal_nervous_system	1.59675097
31	MP0002733_abnormal_thermal_nociception	1.59173290
32	MP0008775_abnormal_heart_ventricle	1.57050277
33	MP0002638_abnormal_pupillary_reflex	1.54947932
34	MP0003718_maternal_effect	1.52950591
35	MP0005394_taste/olfaction_phenotype	1.49374849
36	MP0005499_abnormal_olfactory_system	1.49374849
37	MP0002822_catalepsy	1.49022236
38	MP0004147_increased_porphyrin_level	1.45684651
39	MP0003136_yellow_coat_color	1.45419197
40	MP0003880_abnormal_central_pattern	1.44221619
41	MP0004133_heterotaxia	1.42431357
42	MP0001919_abnormal_reproductive_system	1.41263153
43	MP0002653_abnormal_ependyma_morphology	1.38620268
44	MP0001346_abnormal_lacrimal_gland	1.34048950
45	MP0002928_abnormal_bile_duct	1.32266053
46	MP0004043_abnormal_pH_regulation	1.31176070
47	MP0000631_abnormal_neuroendocrine_gland	1.30802015
48	MP0005646_abnormal_pituitary_gland	1.30331020
49	MP0002572_abnormal_emotion/affect_behav	1.28667818
50	MP0001835_abnormal_antigen_presentation	1.26359154
51	MP0001970_abnormal_pain_threshold	1.24619981
52	MP0003698_abnormal_male_reproductive	1.24563833
53	MP0002063_abnormal_learning/memory/cond	1.23955512
54	MP0000955_abnormal_spinal_cord	1.23649917
55	MP0003890_abnormal_embryonic-extraembry	1.23545272
56	MP0005167_abnormal_blood-brain_barrier	1.23116756
57	MP0002064_seizures	1.21784911
58	MP0001188_hyperpigmentation	1.18197952
59	MP0008872_abnormal_physiological_respon	1.16020711
60	MP0001984_abnormal_olfaction	1.15970404
61	MP0002282_abnormal_trachea_morphology	1.15094128
62	MP0001968_abnormal_touch/_nociception	1.14993352
63	MP0004782_abnormal_surfactant_physiolog	1.13982208
64	MP0010386_abnormal_urinary_bladder	1.13092784
65	MP0001485_abnormal_pinna_reflex	1.12554991
66	MP0005671_abnormal_response_to	1.08710079
67	MP0000026_abnormal_inner_ear	1.07312570
68	MP0001929_abnormal_gametogenesis	1.06792560
69	MP0005551_abnormal_eye_electrophysiolog	1.06747360
70	MP0002557_abnormal_social/conspecific_i	1.06075459
71	MP0003635_abnormal_synaptic_transmissio	1.02811558
72	MP0002160_abnormal_reproductive_system	1.02184390
73	MP0005085_abnormal_gallbladder_physiolo	1.01884355
74	MP0001486_abnormal_startle_reflex	1.01351367
75	MP0003656_abnormal_erythrocyte_physiolo	0.99414752
76	MP0009053_abnormal_anal_canal	0.97465928
77	MP0005389_reproductive_system_phenotype	0.96494616
78	MP0002693_abnormal_pancreas_physiology	0.95563607
79	MP0008877_abnormal_DNA_methylation	0.95534456
80	MP0000465_gastrointestinal_hemorrhage	0.95409961
81	MP0002734_abnormal_mechanical_nocicepti	0.94645275
82	MP0000230_abnormal_systemic_arterial	0.92503631
83	MP0000778_abnormal_nervous_system	0.92360603
84	MP0004924_abnormal_behavior	0.89835162
85	MP0005386_behavior/neurological_phenoty	0.89835162
86	MP0004130_abnormal_muscle_cell	0.89677350
87	MP0002184_abnormal_innervation	0.88962521
88	MP0002909_abnormal_adrenal_gland	0.88132107
89	MP0009379_abnormal_foot_pigmentation	0.87216673
90	MP0003119_abnormal_digestive_system	0.86490918
91	MP0002229_neurodegeneration	0.85113895
92	MP0004742_abnormal_vestibular_system	0.84884597
93	MP0009046_muscle_twitch	0.84251837
94	MP0009697_abnormal_copulation	0.84066294
95	MP0001963_abnormal_hearing_physiology	0.80132399
96	MP0004885_abnormal_endolymph	0.79809991
97	MP0001440_abnormal_grooming_behavior	0.79772635
98	MP0002938_white_spotting	0.78906579
99	MP0000733_abnormal_muscle_development	0.78341045
100	MP0002932_abnormal_joint_morphology	0.77963348

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Retinal dysplasia (HP:0007973)	4.20095339
2	Abnormal rod and cone electroretinograms (HP:0008323)	4.05894688
3	Type II lissencephaly (HP:0007260)	3.84381455
4	Decreased central vision (HP:0007663)	3.78166055
5	Neonatal respiratory distress (HP:0002643)	3.63426893
6	Cerebellar dysplasia (HP:0007033)	3.51555542
7	Anterior segment dysgenesis (HP:0007700)	3.50603504
8	Pendular nystagmus (HP:0012043)	3.47501437
9	Absent thumb (HP:0009777)	3.41086544
10	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.28500806
11	Male pseudohermaphroditism (HP:0000037)	3.19232340
12	Increased corneal curvature (HP:0100692)	3.07637524
13	Keratoconus (HP:0000563)	3.07637524
14	Agitation (HP:0000713)	3.00513160
15	Bony spicule pigmentary retinopathy (HP:0007737)	2.96510310
16	Birth length less than 3rd percentile (HP:0003561)	2.90472640
17	Septo-optic dysplasia (HP:0100842)	2.81866454
18	Sclerocornea (HP:0000647)	2.81760273
19	Pancreatic cysts (HP:0001737)	2.64486802
20	True hermaphroditism (HP:0010459)	2.64348815
21	Pancreatic fibrosis (HP:0100732)	2.62814121
22	Reticulocytopenia (HP:0001896)	2.53555268
23	Nephronophthisis (HP:0000090)	2.48687182
24	Status epilepticus (HP:0002133)	2.47217802
25	Inability to walk (HP:0002540)	2.47113823
26	Optic nerve hypoplasia (HP:0000609)	2.45033895
27	Congenital stationary night blindness (HP:0007642)	2.41053116
28	Lissencephaly (HP:0001339)	2.39896021
29	Limb dystonia (HP:0002451)	2.38865859
30	Abnormal ciliary motility (HP:0012262)	2.38434146
31	Attenuation of retinal blood vessels (HP:0007843)	2.38248318
32	Chronic hepatic failure (HP:0100626)	2.35942117
33	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.31157770
34	Maternal diabetes (HP:0009800)	2.28679901
35	Abolished electroretinogram (ERG) (HP:0000550)	2.28031536
36	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.25816860
37	Abnormality of the labia minora (HP:0012880)	2.23741607
38	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.23103254
39	3-Methylglutaconic aciduria (HP:0003535)	2.22676726
40	Acute necrotizing encephalopathy (HP:0006965)	2.21894585
41	Occipital encephalocele (HP:0002085)	2.14727282
42	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.13900916
43	Abnormal respiratory motile cilium morphology (HP:0005938)	2.12013792
44	Abnormal respiratory epithelium morphology (HP:0012253)	2.12013792
45	Molar tooth sign on MRI (HP:0002419)	2.11150187
46	Abnormality of midbrain morphology (HP:0002418)	2.11150187
47	Optic neuritis (HP:0100653)	2.10581823
48	Retrobulbar optic neuritis (HP:0100654)	2.10581823
49	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.08695796
50	Retinal atrophy (HP:0001105)	2.08225469
51	Type 2 muscle fiber atrophy (HP:0003554)	2.07856645
52	Adrenal hypoplasia (HP:0000835)	2.06085516
53	Increased serum lactate (HP:0002151)	2.04415905
54	Biliary tract neoplasm (HP:0100574)	2.04156841
55	Delayed CNS myelination (HP:0002188)	2.03215245
56	Tetany (HP:0001281)	2.01453453
57	Cortical visual impairment (HP:0100704)	2.01064031
58	Abnormal respiratory motile cilium physiology (HP:0012261)	2.01034805
59	Medial flaring of the eyebrow (HP:0010747)	2.00313072
60	Prostate neoplasm (HP:0100787)	1.97572500
61	Progressive inability to walk (HP:0002505)	1.96698706
62	Cone-rod dystrophy (HP:0000548)	1.96288753
63	Muscle fiber atrophy (HP:0100295)	1.91307432
64	Abnormality of the corticospinal tract (HP:0002492)	1.90073495
65	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.89721772
66	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.89721772
67	Gait imbalance (HP:0002141)	1.89326556
68	Bilateral microphthalmos (HP:0007633)	1.87696116
69	Polycystic ovaries (HP:0000147)	1.87446020
70	Meckel diverticulum (HP:0002245)	1.86535368
71	Pachygyria (HP:0001302)	1.86346339
72	Vaginal atresia (HP:0000148)	1.85327402
73	Thyroid-stimulating hormone excess (HP:0002925)	1.84684539
74	Genital tract atresia (HP:0001827)	1.84525075
75	Abdominal situs inversus (HP:0003363)	1.83556161
76	Abnormality of abdominal situs (HP:0011620)	1.83556161
77	Abnormal mitochondria in muscle tissue (HP:0008316)	1.83223354
78	Stomatitis (HP:0010280)	1.83217833
79	Anophthalmia (HP:0000528)	1.81470806
80	Abnormality of the carotid arteries (HP:0005344)	1.80772666
81	Congenital primary aphakia (HP:0007707)	1.79131871
82	Severe visual impairment (HP:0001141)	1.77703347
83	Specific learning disability (HP:0001328)	1.77693195
84	Bicornuate uterus (HP:0000813)	1.77317124
85	Abnormality of the ileum (HP:0001549)	1.75698124
86	Abnormality of the renal medulla (HP:0100957)	1.75313735
87	Upper motor neuron abnormality (HP:0002127)	1.74335095
88	Bile duct proliferation (HP:0001408)	1.74026176
89	Abnormal biliary tract physiology (HP:0012439)	1.74026176
90	Unilateral renal agenesis (HP:0000122)	1.73624111
91	Progressive macrocephaly (HP:0004481)	1.73569281
92	Failure to thrive in infancy (HP:0001531)	1.73325017
93	Hypoalbuminemia (HP:0003073)	1.73183364
94	Abnormal albumin level (HP:0012116)	1.73183364
95	Aplasia/Hypoplasia of the patella (HP:0006498)	1.72438675
96	Microvesicular hepatic steatosis (HP:0001414)	1.72203381
97	Hypoplasia of the radius (HP:0002984)	1.71583813
98	Retinitis pigmentosa (HP:0000510)	1.71154605
99	Sensory axonal neuropathy (HP:0003390)	1.70922755
100	Patellar aplasia (HP:0006443)	1.68963042

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	7.04033498
2	WNK3	3.73618274
3	MAP4K2	3.26388665
4	PNCK	2.94671541
5	PLK2	2.65728821
6	TIE1	2.40407706
7	GRK1	2.26183023
8	CAMKK2	2.08938911
9	TXK	2.08152882
10	MAP2K2	1.88545057
11	WNK4	1.71852221
12	MAP2K6	1.69205674
13	PLK4	1.68847008
14	TAOK3	1.68424030
15	CCNB1	1.57250982
16	MAP3K4	1.56899853
17	DYRK2	1.51708498
18	DDR2	1.41772306
19	TEC	1.41359847
20	WNK1	1.40081010
21	MARK1	1.39298275
22	MAP2K7	1.38508691
23	ADRBK2	1.37952415
24	BRAF	1.37335463
25	PRKCH	1.33847290
26	MAPK13	1.22100649
27	PRKCG	1.19871958
28	TESK1	1.17812780
29	WEE1	1.17141209
30	TLK1	1.12561746
31	DAPK2	1.06426526
32	PIK3CG	1.00938218
33	MAPK15	0.95489840
34	FRK	0.89441013
35	TNIK	0.88629903
36	STK39	0.86633880
37	PAK3	0.86271877
38	PRKAA2	0.85039754
39	MAPKAPK5	0.82104841
40	MAP3K11	0.80736322
41	MINK1	0.78921447
42	ITK	0.77878057
43	RPS6KA4	0.75556928
44	PRKCE	0.72542534
45	CDK7	0.72377191
46	BRD4	0.71210863
47	PRKAA1	0.70751030
48	RPS6KA2	0.69091418
49	BRSK2	0.68249918
50	OXSR1	0.66138886
51	ERBB2	0.63859106
52	CDK3	0.63543153
53	CHUK	0.63305977
54	VRK2	0.62383728
55	BMPR1B	0.61786846
56	RPS6KA6	0.61070469
57	PIK3CA	0.60769373
58	LIMK1	0.60148671
59	MAPKAPK3	0.58418396
60	PHKG1	0.57169219
61	PHKG2	0.57169219
62	STK16	0.57018251
63	PRKCI	0.56758286
64	CDK11A	0.53513223
65	EIF2AK1	0.53426388
66	NEK6	0.52903248
67	VRK1	0.52757972
68	NUAK1	0.52372439
69	GRK6	0.52061337
70	PRKACA	0.49911809
71	PAK6	0.49795647
72	CAMKK1	0.49569110
73	NTRK3	0.49329712
74	CDK19	0.49008904
75	FES	0.47891609
76	MAPK11	0.47873172
77	CSNK1G2	0.47504010
78	SYK	0.46356262
79	PRKCQ	0.45580536
80	RPS6KA5	0.45185672
81	PLK3	0.44008413
82	STK11	0.42143489
83	ZAK	0.42046865
84	PTK2B	0.41158520
85	CAMK2A	0.41127721
86	SGK494	0.40717232
87	SGK223	0.40717232
88	CDK14	0.40713470
89	IGF1R	0.40539993
90	PRKD2	0.40286838
91	IKBKB	0.38343037
92	RPS6KA1	0.38217781
93	DYRK3	0.36915597
94	RPS6KL1	0.36631541
95	RPS6KC1	0.36631541
96	DYRK1A	0.35359915
97	PRKCA	0.33640218
98	PASK	0.33095047
99	NME1	0.32337528
100	PIM1	0.31738059

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.50148067
2	Allograft rejection_Homo sapiens_hsa05330	2.69376145
3	RNA polymerase_Homo sapiens_hsa03020	2.61201532
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.54488219
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.52729090
6	Butanoate metabolism_Homo sapiens_hsa00650	2.52564402
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.51304641
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.42272350
9	Asthma_Homo sapiens_hsa05310	2.38714201
10	Parkinsons disease_Homo sapiens_hsa05012	2.19396286
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.12502821
12	Basal transcription factors_Homo sapiens_hsa03022	2.12125709
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.07514322
14	Linoleic acid metabolism_Homo sapiens_hsa00591	2.01585577
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.91356427
16	Type I diabetes mellitus_Homo sapiens_hsa04940	1.76468059
17	Nicotine addiction_Homo sapiens_hsa05033	1.75356544
18	Protein export_Homo sapiens_hsa03060	1.74015550
19	Phototransduction_Homo sapiens_hsa04744	1.71781938
20	Homologous recombination_Homo sapiens_hsa03440	1.62868457
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.62072190
22	Olfactory transduction_Homo sapiens_hsa04740	1.57233385
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.51158781
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.47373330
25	Ribosome_Homo sapiens_hsa03010	1.45998972
26	Caffeine metabolism_Homo sapiens_hsa00232	1.44564928
27	Graft-versus-host disease_Homo sapiens_hsa05332	1.43866360
28	Taste transduction_Homo sapiens_hsa04742	1.41292748
29	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.36564818
30	Huntingtons disease_Homo sapiens_hsa05016	1.35572163
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.33508556
32	Arginine and proline metabolism_Homo sapiens_hsa00330	1.33308159
33	Proteasome_Homo sapiens_hsa03050	1.33211117
34	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.27622025
35	Fatty acid degradation_Homo sapiens_hsa00071	1.25196861
36	Alzheimers disease_Homo sapiens_hsa05010	1.24128398
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.22340550
38	Steroid biosynthesis_Homo sapiens_hsa00100	1.22094163
39	Fat digestion and absorption_Homo sapiens_hsa04975	1.17606472
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.10905141
41	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.09785474
42	Ether lipid metabolism_Homo sapiens_hsa00565	1.09665611
43	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.04881607
44	Glycerolipid metabolism_Homo sapiens_hsa00561	0.98326796
45	Collecting duct acid secretion_Homo sapiens_hsa04966	0.97885904
46	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.97610535
47	Serotonergic synapse_Homo sapiens_hsa04726	0.94698987
48	Nitrogen metabolism_Homo sapiens_hsa00910	0.92252189
49	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.91686859
50	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.89006529
51	Morphine addiction_Homo sapiens_hsa05032	0.88445079
52	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.86444279
53	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.85264791
54	RNA degradation_Homo sapiens_hsa03018	0.84988483
55	GABAergic synapse_Homo sapiens_hsa04727	0.84801457
56	Pyrimidine metabolism_Homo sapiens_hsa00240	0.83676965
57	ABC transporters_Homo sapiens_hsa02010	0.83195403
58	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.78332188
59	Retinol metabolism_Homo sapiens_hsa00830	0.76472635
60	Sulfur relay system_Homo sapiens_hsa04122	0.75816272
61	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.74870370
62	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74842823
63	Histidine metabolism_Homo sapiens_hsa00340	0.74747890
64	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.74113017
65	Pyruvate metabolism_Homo sapiens_hsa00620	0.72840353
66	Purine metabolism_Homo sapiens_hsa00230	0.72017770
67	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.71374948
68	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.67110543
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61997840
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60633406
71	Peroxisome_Homo sapiens_hsa04146	0.59789445
72	Circadian entrainment_Homo sapiens_hsa04713	0.59715545
73	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.58378492
74	Salivary secretion_Homo sapiens_hsa04970	0.57883413
75	Fatty acid metabolism_Homo sapiens_hsa01212	0.57572963
76	Selenocompound metabolism_Homo sapiens_hsa00450	0.57022552
77	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.56330020
78	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.56261429
79	Phenylalanine metabolism_Homo sapiens_hsa00360	0.53213434
80	Type II diabetes mellitus_Homo sapiens_hsa04930	0.52966636
81	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.52185149
82	Metabolic pathways_Homo sapiens_hsa01100	0.51983546
83	Glutamatergic synapse_Homo sapiens_hsa04724	0.51078406
84	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.50074722
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.49334229
86	Insulin secretion_Homo sapiens_hsa04911	0.48420444
87	Regulation of autophagy_Homo sapiens_hsa04140	0.47442808
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.44808011
89	RNA transport_Homo sapiens_hsa03013	0.38062454
90	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.37852810
91	Antigen processing and presentation_Homo sapiens_hsa04612	0.36863744
92	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.34594459
93	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.34200952
94	Mineral absorption_Homo sapiens_hsa04978	0.32818933
95	Circadian rhythm_Homo sapiens_hsa04710	0.32196684
96	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.30679133
97	Viral myocarditis_Homo sapiens_hsa05416	0.30468610
98	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.28879467
99	Rheumatoid arthritis_Homo sapiens_hsa05323	0.25949224
100	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.23410199

RPS26P52

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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