ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maturation of SSU-rRNA (GO:0030490)	9.60124679
2	ribosomal small subunit assembly (GO:0000028)	7.09739191
3	chaperone-mediated protein transport (GO:0072321)	6.89416723
4	ribosomal small subunit biogenesis (GO:0042274)	6.43050166
5	viral transcription (GO:0019083)	6.36608916
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.29504769
7	ATP synthesis coupled proton transport (GO:0015986)	6.29504769
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.25196604
9	translational termination (GO:0006415)	6.23234174
10	DNA deamination (GO:0045006)	5.85498638
11	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.33222594
12	translational elongation (GO:0006414)	5.26626300
13	cotranslational protein targeting to membrane (GO:0006613)	5.24545595
14	protein targeting to ER (GO:0045047)	5.24153992
15	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.98936289
16	ribosomal large subunit biogenesis (GO:0042273)	4.98138413
17	protein localization to endoplasmic reticulum (GO:0070972)	4.88063846
18	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.78385046
19	cellular protein complex disassembly (GO:0043624)	4.61712161
20	protein neddylation (GO:0045116)	4.52676282
21	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.45153644
22	viral life cycle (GO:0019058)	4.44945426
23	respiratory electron transport chain (GO:0022904)	4.42270389
24	water-soluble vitamin biosynthetic process (GO:0042364)	4.39434005
25	electron transport chain (GO:0022900)	4.37904632
26	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.37057286
27	proteasome assembly (GO:0043248)	4.35576117
28	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.14083273
29	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.14083273
30	protein complex biogenesis (GO:0070271)	4.04992071
31	translational initiation (GO:0006413)	4.01062447
32	protein K6-linked ubiquitination (GO:0085020)	3.98691697
33	translation (GO:0006412)	3.97504487
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.93081749
35	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.93081749
36	NADH dehydrogenase complex assembly (GO:0010257)	3.93081749
37	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.91903009
38	termination of RNA polymerase III transcription (GO:0006386)	3.91903009
39	mitochondrial respiratory chain complex assembly (GO:0033108)	3.91538206
40	kynurenine metabolic process (GO:0070189)	3.88502100
41	protein complex disassembly (GO:0043241)	3.80436866
42	multicellular organism reproduction (GO:0032504)	3.75215263
43	macromolecular complex disassembly (GO:0032984)	3.68709816
44	negative regulation of mast cell activation (GO:0033004)	3.66375212
45	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.60940557
46	pseudouridine synthesis (GO:0001522)	3.57805085
47	ribonucleoprotein complex biogenesis (GO:0022613)	3.55697323
48	cellular component biogenesis (GO:0044085)	3.54342418
49	protein targeting to membrane (GO:0006612)	3.53452596
50	ATP biosynthetic process (GO:0006754)	3.52336789
51	hydrogen ion transmembrane transport (GO:1902600)	3.48907631
52	organelle disassembly (GO:1903008)	3.43226377
53	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.43042990
54	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.42841478
55	spindle assembly involved in mitosis (GO:0090307)	3.39576013
56	protein-cofactor linkage (GO:0018065)	3.34391818
57	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.34335882
58	indole-containing compound catabolic process (GO:0042436)	3.31789365
59	indolalkylamine catabolic process (GO:0046218)	3.31789365
60	tryptophan catabolic process (GO:0006569)	3.31789365
61	regulation of meiosis I (GO:0060631)	3.31577821
62	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.28734975
63	positive regulation of meiosis (GO:0045836)	3.18756781
64	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.18182899
65	indolalkylamine metabolic process (GO:0006586)	3.18083951
66	neuron fate determination (GO:0048664)	3.15997167
67	mRNA catabolic process (GO:0006402)	3.13615905
68	negative regulation of nitric-oxide synthase activity (GO:0051001)	3.11533709
69	L-methionine salvage (GO:0071267)	3.08475311
70	L-methionine biosynthetic process (GO:0071265)	3.08475311
71	amino acid salvage (GO:0043102)	3.08475311
72	positive regulation of meiotic cell cycle (GO:0051446)	3.07864211
73	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.06830443
74	proton transport (GO:0015992)	3.05176440
75	synapsis (GO:0007129)	3.03224112
76	hydrogen transport (GO:0006818)	2.97853222
77	negative regulation of catenin import into nucleus (GO:0035414)	2.95580701
78	respiratory chain complex IV assembly (GO:0008535)	2.87804805
79	axonemal dynein complex assembly (GO:0070286)	2.87690823
80	protein localization to cilium (GO:0061512)	2.87029935
81	oxidative phosphorylation (GO:0006119)	2.83415899
82	RNA catabolic process (GO:0006401)	2.81698489
83	microtubule cytoskeleton organization involved in mitosis (GO:1902850)	2.80297845
84	rRNA processing (GO:0006364)	2.79101543
85	S-adenosylmethionine metabolic process (GO:0046500)	2.78971373
86	tryptophan metabolic process (GO:0006568)	2.74379877
87	intracellular protein transmembrane import (GO:0044743)	2.73486319
88	DNA replication checkpoint (GO:0000076)	2.72627470
89	rRNA metabolic process (GO:0016072)	2.72505769
90	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.68621942
91	behavioral response to nicotine (GO:0035095)	2.68302757
92	regulation of neurotransmitter uptake (GO:0051580)	2.66731082
93	somite development (GO:0061053)	2.63748851
94	lung lobe morphogenesis (GO:0060463)	2.59561745
95	nucleoside triphosphate biosynthetic process (GO:0009142)	2.58210681
96	platelet dense granule organization (GO:0060155)	2.57381677
97	regulation of transcription from RNA polymerase I promoter (GO:0006356)	2.57252113
98	aerobic respiration (GO:0009060)	2.53673928
99	protein targeting to mitochondrion (GO:0006626)	2.53267483
100	cytochrome complex assembly (GO:0017004)	2.49744274

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.27245013
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.83867336
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.58609089
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.57731566
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.45295245
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.09447842
7	VDR_22108803_ChIP-Seq_LS180_Human	2.91146677
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.86493983
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.57272164
10	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.48849681
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.31037628
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.29128778
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.26465524
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.21060929
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14845176
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.09098489
17	EWS_26573619_Chip-Seq_HEK293_Human	2.01988485
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.95233313
19	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.90687042
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.88203757
21	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.86264424
22	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.86230996
23	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.83327672
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.76239072
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.75459883
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.66713419
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.63136754
28	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.60125123
29	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.57373037
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.53299115
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.51051056
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.50759039
33	ZNF274_21170338_ChIP-Seq_K562_Hela	1.49020038
34	NCOR_22424771_ChIP-Seq_293T_Human	1.47009209
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43234860
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.42645759
37	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.42404001
38	TTF2_22483619_ChIP-Seq_HELA_Human	1.41946145
39	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.41928310
40	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.41796746
41	FOXP3_21729870_ChIP-Seq_TREG_Human	1.41699248
42	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.40071105
43	P300_19829295_ChIP-Seq_ESCs_Human	1.38726494
44	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.38438622
45	GBX2_23144817_ChIP-Seq_PC3_Human	1.36471952
46	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.30391033
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29477759
48	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.28502646
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.27037414
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27037414
51	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.26814818
52	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.22370749
53	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20232283
54	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.19000068
55	TAF2_19829295_ChIP-Seq_ESCs_Human	1.15421340
56	IRF1_19129219_ChIP-ChIP_H3396_Human	1.13722672
57	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12687587
58	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.12466451
59	ER_23166858_ChIP-Seq_MCF-7_Human	1.11945239
60	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.11655673
61	MYC_19829295_ChIP-Seq_ESCs_Human	1.10148998
62	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.09739870
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08993144
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08993144
65	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.08433114
66	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.08391592
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07899382
68	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06290830
69	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.05555466
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.05326419
71	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.03766446
72	FUS_26573619_Chip-Seq_HEK293_Human	1.03494666
73	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03195998
74	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.02986773
75	ERA_21632823_ChIP-Seq_H3396_Human	1.02514517
76	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.01820991
77	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.00053559
78	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.99822805
79	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.98545771
80	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98409749
81	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97805289
82	NANOG_20526341_ChIP-Seq_ESCs_Human	0.96988219
83	AR_20517297_ChIP-Seq_VCAP_Human	0.96480714
84	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.95917018
85	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.91319487
86	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.90224724
87	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.89389657
88	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.89013550
89	TAF15_26573619_Chip-Seq_HEK293_Human	0.88316716
90	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.87738106
91	AR_25329375_ChIP-Seq_VCAP_Human	0.87715833
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.87262996
93	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.87262563
94	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.86492720
95	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.86408242
96	HTT_18923047_ChIP-ChIP_STHdh_Human	0.86344272
97	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.86240393
98	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.85734937
99	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.85243146
100	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.82294071

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.78413466
2	MP0006292_abnormal_olfactory_placode	4.90360428
3	MP0003646_muscle_fatigue	3.12754549
4	MP0006072_abnormal_retinal_apoptosis	3.11171051
5	MP0008875_abnormal_xenobiotic_pharmacok	2.63355214
6	MP0002160_abnormal_reproductive_system	2.47913451
7	MP0004147_increased_porphyrin_level	2.30298400
8	MP0002163_abnormal_gland_morphology	2.29112762
9	MP0004145_abnormal_muscle_electrophysio	2.27407490
10	MP0004885_abnormal_endolymph	2.26052889
11	MP0008877_abnormal_DNA_methylation	2.20736455
12	MP0009053_abnormal_anal_canal	2.07942362
13	MP0003283_abnormal_digestive_organ	2.04776379
14	MP0005389_reproductive_system_phenotype	1.94701440
15	MP0005646_abnormal_pituitary_gland	1.94075862
16	MP0005423_abnormal_somatic_nervous	1.93583050
17	MP0002102_abnormal_ear_morphology	1.82779520
18	MP0002938_white_spotting	1.80378905
19	MP0008058_abnormal_DNA_repair	1.75446865
20	MP0005551_abnormal_eye_electrophysiolog	1.69868485
21	MP0000631_abnormal_neuroendocrine_gland	1.67798931
22	MP0003186_abnormal_redox_activity	1.64759931
23	MP0006276_abnormal_autonomic_nervous	1.63931915
24	MP0003195_calcinosis	1.60597540
25	MP0003011_delayed_dark_adaptation	1.58175812
26	MP0002837_dystrophic_cardiac_calcinosis	1.54264724
27	MP0005379_endocrine/exocrine_gland_phen	1.51101145
28	MP0006036_abnormal_mitochondrial_physio	1.50414405
29	MP0001293_anophthalmia	1.46301879
30	MP0004142_abnormal_muscle_tone	1.43114869
31	MP0003950_abnormal_plasma_membrane	1.41139666
32	MP0001440_abnormal_grooming_behavior	1.39682790
33	MP0003880_abnormal_central_pattern	1.31568413
34	MP0005253_abnormal_eye_physiology	1.30349506
35	MP0000049_abnormal_middle_ear	1.28841166
36	MP0005645_abnormal_hypothalamus_physiol	1.25499272
37	MP0000026_abnormal_inner_ear	1.24011021
38	MP0004043_abnormal_pH_regulation	1.23427224
39	MP0009745_abnormal_behavioral_response	1.22629764
40	MP0002095_abnormal_skin_pigmentation	1.21596631
41	MP0005410_abnormal_fertilization	1.19317237
42	MP0005360_urolithiasis	1.18795996
43	MP0005084_abnormal_gallbladder_morpholo	1.17858542
44	MP0002272_abnormal_nervous_system	1.16222328
45	MP0008260_abnormal_autophagy	1.14705672
46	MP0008872_abnormal_physiological_respon	1.14334039
47	MP0002751_abnormal_autonomic_nervous	1.14284726
48	MP0001119_abnormal_female_reproductive	1.11900641
49	MP0001968_abnormal_touch/_nociception	1.11063281
50	MP0003119_abnormal_digestive_system	1.10176014
51	MP0003938_abnormal_ear_development	1.07568257
52	MP0002234_abnormal_pharynx_morphology	1.07239870
53	MP0003879_abnormal_hair_cell	1.06805963
54	MP0002210_abnormal_sex_determination	1.06051931
55	MP0005671_abnormal_response_to	1.05871701
56	MP0009046_muscle_twitch	1.04733619
57	MP0006035_abnormal_mitochondrial_morpho	1.03478003
58	MP0002928_abnormal_bile_duct	1.02106696
59	MP0001905_abnormal_dopamine_level	1.01580338
60	MP0008775_abnormal_heart_ventricle	1.00439926
61	MP0001986_abnormal_taste_sensitivity	0.98763715
62	MP0003866_abnormal_defecation	0.96514626
63	MP0009764_decreased_sensitivity_to	0.96006688
64	MP0001919_abnormal_reproductive_system	0.95424458
65	MP0005408_hypopigmentation	0.95013669
66	MP0003718_maternal_effect	0.93931102
67	MP0001929_abnormal_gametogenesis	0.93701703
68	MP0008789_abnormal_olfactory_epithelium	0.91967433
69	MP0001963_abnormal_hearing_physiology	0.89649073
70	MP0003806_abnormal_nucleotide_metabolis	0.89635690
71	MP0001286_abnormal_eye_development	0.89437906
72	MP0004742_abnormal_vestibular_system	0.88394805
73	MP0005195_abnormal_posterior_eye	0.87425846
74	MP0002282_abnormal_trachea_morphology	0.85367213
75	MP0002752_abnormal_somatic_nervous	0.82884851
76	MP0000778_abnormal_nervous_system	0.80647580
77	MP0002184_abnormal_innervation	0.78321707
78	MP0000653_abnormal_sex_gland	0.77917534
79	MP0002557_abnormal_social/conspecific_i	0.77578330
80	MP0005391_vision/eye_phenotype	0.74908730
81	MP0001542_abnormal_bone_strength	0.72280430
82	MP0005332_abnormal_amino_acid	0.71597651
83	MP0001764_abnormal_homeostasis	0.71471294
84	MP0002733_abnormal_thermal_nociception	0.70943848
85	MP0001502_abnormal_circadian_rhythm	0.70667628
86	MP0000428_abnormal_craniofacial_morphol	0.69479189
87	MP0003698_abnormal_male_reproductive	0.69329226
88	MP0000678_abnormal_parathyroid_gland	0.68160369
89	MP0002736_abnormal_nociception_after	0.68135892
90	MP0000647_abnormal_sebaceous_gland	0.67616010
91	MP0000427_abnormal_hair_cycle	0.67346832
92	MP0004215_abnormal_myocardial_fiber	0.67322356
93	MP0010094_abnormal_chromosome_stability	0.67181655
94	MP0001145_abnormal_male_reproductive	0.66894838
95	MP0005075_abnormal_melanosome_morpholog	0.66408942
96	MP0000537_abnormal_urethra_morphology	0.65919570
97	MP0003638_abnormal_response/metabolism_	0.65874349
98	MP0000639_abnormal_adrenal_gland	0.65805029
99	MP0005167_abnormal_blood-brain_barrier	0.65599436
100	MP0004133_heterotaxia	0.64612853

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	4.56389467
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.26234542
3	Reticulocytopenia (HP:0001896)	4.18332547
4	Lipid accumulation in hepatocytes (HP:0006561)	4.15355846
5	Mitochondrial inheritance (HP:0001427)	4.10882774
6	Renal Fanconi syndrome (HP:0001994)	4.02890628
7	Acute necrotizing encephalopathy (HP:0006965)	3.81876425
8	Macrocytic anemia (HP:0001972)	3.75600319
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.65407608
10	Increased CSF lactate (HP:0002490)	3.64835602
11	Acute encephalopathy (HP:0006846)	3.53172128
12	Pancreatic fibrosis (HP:0100732)	3.48283005
13	Hepatocellular necrosis (HP:0001404)	3.48159593
14	Pancreatic cysts (HP:0001737)	3.37863639
15	Abnormality of cells of the erythroid lineage (HP:0012130)	3.30620645
16	Increased serum lactate (HP:0002151)	3.17525911
17	Exertional dyspnea (HP:0002875)	3.17380403
18	Hepatic necrosis (HP:0002605)	3.16740328
19	Colon cancer (HP:0003003)	3.12979857
20	Progressive macrocephaly (HP:0004481)	3.07749876
21	True hermaphroditism (HP:0010459)	3.02701965
22	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.01982964
23	Abnormal number of erythroid precursors (HP:0012131)	3.01472553
24	Increased intramyocellular lipid droplets (HP:0012240)	2.99137469
25	Stenosis of the external auditory canal (HP:0000402)	2.96649386
26	Septo-optic dysplasia (HP:0100842)	2.88039384
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.87417129
28	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.83145673
29	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.80806615
30	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.80806615
31	Pallor (HP:0000980)	2.78558985
32	Occipital encephalocele (HP:0002085)	2.77484753
33	Constricted visual fields (HP:0001133)	2.75169649
34	Pendular nystagmus (HP:0012043)	2.73504575
35	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.71652818
36	Nephronophthisis (HP:0000090)	2.60858595
37	Lactic acidosis (HP:0003128)	2.52142774
38	Abnormality of urine glucose concentration (HP:0011016)	2.51733703
39	Glycosuria (HP:0003076)	2.51733703
40	Asplenia (HP:0001746)	2.51582026
41	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.44264577
42	Cerebral edema (HP:0002181)	2.43489717
43	Abnormality of renal resorption (HP:0011038)	2.42764135
44	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.42585605
45	Increased muscle lipid content (HP:0009058)	2.41584958
46	Microvesicular hepatic steatosis (HP:0001414)	2.36328044
47	3-Methylglutaconic aciduria (HP:0003535)	2.35407403
48	Abnormality of the renal medulla (HP:0100957)	2.33349741
49	Abnormal respiratory motile cilium physiology (HP:0012261)	2.31846751
50	Bilateral microphthalmos (HP:0007633)	2.29540035
51	Short tibia (HP:0005736)	2.20493993
52	Respiratory failure (HP:0002878)	2.20294857
53	Methylmalonic acidemia (HP:0002912)	2.19194251
54	Abnormality of the anterior horn cell (HP:0006802)	2.16083924
55	Degeneration of anterior horn cells (HP:0002398)	2.16083924
56	Medial flaring of the eyebrow (HP:0010747)	2.11706716
57	Optic disc pallor (HP:0000543)	2.11110613
58	Amelogenesis imperfecta (HP:0000705)	2.07009475
59	Genital tract atresia (HP:0001827)	2.06764172
60	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.06534243
61	Abnormality of lateral ventricle (HP:0030047)	2.04355627
62	Decreased central vision (HP:0007663)	2.03520520
63	Abnormality of the renal cortex (HP:0011035)	2.01146728
64	Bony spicule pigmentary retinopathy (HP:0007737)	2.00378221
65	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.99523141
66	Postaxial foot polydactyly (HP:0001830)	1.99067359
67	Adrenal hypoplasia (HP:0000835)	1.97608832
68	Maternal diabetes (HP:0009800)	1.97564723
69	Confusion (HP:0001289)	1.95752591
70	CNS demyelination (HP:0007305)	1.94202517
71	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.94088712
72	Renal cortical cysts (HP:0000803)	1.94075482
73	Abnormality of midbrain morphology (HP:0002418)	1.93789096
74	Molar tooth sign on MRI (HP:0002419)	1.93789096
75	Supernumerary spleens (HP:0009799)	1.92343757
76	Abnormal ciliary motility (HP:0012262)	1.91486823
77	Respiratory difficulties (HP:0002880)	1.91041444
78	Abnormality of the labia minora (HP:0012880)	1.88243789
79	Abnormality of serum amino acid levels (HP:0003112)	1.87953289
80	Absent thumb (HP:0009777)	1.87902210
81	Hyperventilation (HP:0002883)	1.87741910
82	Abnormality of macular pigmentation (HP:0008002)	1.85819417
83	Triphalangeal thumb (HP:0001199)	1.85393979
84	Morphological abnormality of the middle ear (HP:0008609)	1.84799885
85	Congenital stationary night blindness (HP:0007642)	1.84659008
86	Lethargy (HP:0001254)	1.83160519
87	Leukodystrophy (HP:0002415)	1.83065888
88	Sclerocornea (HP:0000647)	1.82840346
89	Premature ovarian failure (HP:0008209)	1.81427992
90	Cystic liver disease (HP:0006706)	1.80864395
91	Optic nerve hypoplasia (HP:0000609)	1.80713859
92	Abolished electroretinogram (ERG) (HP:0000550)	1.80021490
93	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.79852049
94	Absent/shortened dynein arms (HP:0200106)	1.79852049
95	Absent phalangeal crease (HP:0006109)	1.79843517
96	Congenital sensorineural hearing impairment (HP:0008527)	1.79531469
97	Fair hair (HP:0002286)	1.79309110
98	Congenital, generalized hypertrichosis (HP:0004540)	1.79024499
99	Vaginal atresia (HP:0000148)	1.77959072
100	Generalized tonic-clonic seizures (HP:0002069)	1.77412567

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	4.57010861
2	STK16	4.05306924
3	STK38L	2.74393948
4	GRK1	2.69802609
5	NTRK3	2.45833797
6	VRK2	2.36726913
7	ZAK	2.15560941
8	BUB1	2.07163858
9	CDC7	2.07106199
10	PIK3CA	2.02500962
11	VRK1	1.97121633
12	TXK	1.96340372
13	KDR	1.64158797
14	STK24	1.59617620
15	BMPR1B	1.54968961
16	PLK2	1.48295152
17	TYRO3	1.37918271
18	TEC	1.36502957
19	FRK	1.34287708
20	AURKA	1.32605689
21	ADRBK2	1.30043239
22	TAOK3	1.29745828
23	OXSR1	1.28093244
24	WNK1	1.27501396
25	ACVR1B	1.24834346
26	WNK4	1.19698629
27	WNK3	1.15549173
28	NEK1	1.15028449
29	MST4	1.06742174
30	CDK19	1.05273134
31	INSRR	1.05221717
32	LIMK1	1.03804867
33	MAPK13	1.00515345
34	CAMK1D	1.00074756
35	CHEK2	0.97300187
36	CAMKK2	0.91099266
37	NUAK1	0.90864359
38	ERBB2	0.90161658
39	PHKG2	0.89815993
40	PHKG1	0.89815993
41	CAMK1	0.89414954
42	PLK1	0.88952693
43	ATR	0.87478752
44	RPS6KA6	0.84916479
45	CSNK1G2	0.83248386
46	RPS6KA5	0.82822966
47	MAPKAPK5	0.82772765
48	MARK3	0.81372711
49	GRK6	0.81159937
50	PLK4	0.81155190
51	MKNK1	0.79567378
52	PLK3	0.78367919
53	STK39	0.76421410
54	NME1	0.73883948
55	ERBB4	0.71143790
56	SIK2	0.70352926
57	IKBKB	0.69719200
58	CDK8	0.69594454
59	ITK	0.69264553
60	AURKB	0.68221726
61	CAMK2A	0.66915070
62	TESK2	0.66660429
63	CSNK1G3	0.65105685
64	MYLK	0.64195915
65	IGF1R	0.63299436
66	OBSCN	0.63039019
67	RPS6KL1	0.62497419
68	RPS6KC1	0.62497419
69	GRK7	0.60615979
70	RPS6KA4	0.60345157
71	PIM1	0.58832605
72	PRKCG	0.55695894
73	PAK6	0.55016081
74	CDK3	0.54326077
75	DYRK2	0.54148733
76	PRKACA	0.53490070
77	SYK	0.52980523
78	CDK14	0.52911181
79	MAP4K2	0.52593298
80	EIF2AK1	0.52476697
81	CAMK4	0.52436745
82	SIK3	0.52018135
83	PKN1	0.50979042
84	EIF2AK3	0.50183114
85	CSNK2A1	0.49429062
86	CSNK1A1	0.48571832
87	CSNK1G1	0.48306686
88	STK3	0.47927486
89	BTK	0.47375593
90	CSNK2A2	0.45936832
91	RPS6KB2	0.45759990
92	TNIK	0.44916919
93	PRKCQ	0.44413507
94	PRKCA	0.43924510
95	DAPK2	0.43468328
96	SRPK1	0.41353875
97	MAP2K2	0.41239975
98	CDK9	0.39660360
99	LCK	0.38932314
100	DYRK3	0.38778726

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.92266663
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.40533787
3	Parkinsons disease_Homo sapiens_hsa05012	3.48818874
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.55665024
5	Huntingtons disease_Homo sapiens_hsa05016	2.54178626
6	Alzheimers disease_Homo sapiens_hsa05010	2.52717369
7	RNA polymerase_Homo sapiens_hsa03020	2.51116711
8	Proteasome_Homo sapiens_hsa03050	2.32555027
9	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.28313391
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.11991363
11	Mismatch repair_Homo sapiens_hsa03430	2.11937267
12	One carbon pool by folate_Homo sapiens_hsa00670	2.10279533
13	Cardiac muscle contraction_Homo sapiens_hsa04260	2.09339522
14	Homologous recombination_Homo sapiens_hsa03440	2.05524655
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.99793309
16	Protein export_Homo sapiens_hsa03060	1.88432021
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.78974818
18	DNA replication_Homo sapiens_hsa03030	1.74474853
19	Fatty acid elongation_Homo sapiens_hsa00062	1.65674692
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.63796840
21	Asthma_Homo sapiens_hsa05310	1.59451855
22	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.53555916
23	Nucleotide excision repair_Homo sapiens_hsa03420	1.45140217
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.43951515
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.39804413
26	Collecting duct acid secretion_Homo sapiens_hsa04966	1.37872446
27	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.34892642
28	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.33865857
29	RNA degradation_Homo sapiens_hsa03018	1.22435567
30	Sulfur relay system_Homo sapiens_hsa04122	1.14212871
31	Graft-versus-host disease_Homo sapiens_hsa05332	1.13852992
32	Allograft rejection_Homo sapiens_hsa05330	1.13780756
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.03328401
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.99863165
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.98734561
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.97578831
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.97197214
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.95059685
39	Non-homologous end-joining_Homo sapiens_hsa03450	0.94333838
40	Rheumatoid arthritis_Homo sapiens_hsa05323	0.89807972
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.87928841
42	Phototransduction_Homo sapiens_hsa04744	0.85583371
43	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84151060
44	Retinol metabolism_Homo sapiens_hsa00830	0.82966463
45	Basal transcription factors_Homo sapiens_hsa03022	0.79803042
46	Olfactory transduction_Homo sapiens_hsa04740	0.76089681
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.74861388
48	Spliceosome_Homo sapiens_hsa03040	0.74252693
49	Peroxisome_Homo sapiens_hsa04146	0.73612608
50	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.73586962
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.72272681
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.70432496
53	Type I diabetes mellitus_Homo sapiens_hsa04940	0.70406284
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69095321
55	Nicotine addiction_Homo sapiens_hsa05033	0.67249126
56	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.67182760
57	Primary immunodeficiency_Homo sapiens_hsa05340	0.66888119
58	Purine metabolism_Homo sapiens_hsa00230	0.66601578
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65835025
60	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65009090
61	RNA transport_Homo sapiens_hsa03013	0.64616380
62	Metabolic pathways_Homo sapiens_hsa01100	0.61371806
63	Base excision repair_Homo sapiens_hsa03410	0.60963777
64	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.59975777
65	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.58866899
66	Propanoate metabolism_Homo sapiens_hsa00640	0.57581241
67	Antigen processing and presentation_Homo sapiens_hsa04612	0.55790253
68	Fatty acid degradation_Homo sapiens_hsa00071	0.54982199
69	Basal cell carcinoma_Homo sapiens_hsa05217	0.51889970
70	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.51738522
71	Circadian entrainment_Homo sapiens_hsa04713	0.51319110
72	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.51027453
73	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.51016386
74	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.50053014
75	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.49842091
76	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.49667884
77	Serotonergic synapse_Homo sapiens_hsa04726	0.46254035
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.44088061
79	Renin-angiotensin system_Homo sapiens_hsa04614	0.40199542
80	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.39654587
81	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.39483889
82	Cocaine addiction_Homo sapiens_hsa05030	0.38310388
83	Morphine addiction_Homo sapiens_hsa05032	0.37507389
84	Glutathione metabolism_Homo sapiens_hsa00480	0.37505636
85	Caffeine metabolism_Homo sapiens_hsa00232	0.37360424
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.37281288
87	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.37151145
88	Glutamatergic synapse_Homo sapiens_hsa04724	0.37045398
89	Sulfur metabolism_Homo sapiens_hsa00920	0.31298546
90	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.30148855
91	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.27900294
92	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.25523724
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.25187215
94	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.24706491
95	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.23436193
96	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.22860671
97	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.21759692
98	Regulation of autophagy_Homo sapiens_hsa04140	0.21753175
99	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.17743413
100	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.16977032

RPS26P54

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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