ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.63013373
2	regulation of chronic inflammatory response (GO:0002676)	6.54532181
3	positive regulation of prostaglandin secretion (GO:0032308)	5.51970059
4	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.67582948
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.62579673
6	ATP synthesis coupled proton transport (GO:0015986)	4.62579673
7	regulation of prostaglandin secretion (GO:0032306)	4.49999947
8	purine-containing compound salvage (GO:0043101)	4.36616014
9	cytidine deamination (GO:0009972)	4.35482758
10	cytidine metabolic process (GO:0046087)	4.35482758
11	cytidine catabolic process (GO:0006216)	4.35482758
12	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	4.25553890
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.21605789
14	protein-cofactor linkage (GO:0018065)	4.04444185
15	regulation of fever generation (GO:0031620)	4.03819024
16	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.02446574
17	positive regulation of heat generation (GO:0031652)	4.02128914
18	positive regulation of defense response to virus by host (GO:0002230)	3.77805385
19	activated T cell proliferation (GO:0050798)	3.76599654
20	ribosomal small subunit assembly (GO:0000028)	3.76233752
21	purine nucleotide salvage (GO:0032261)	3.75959491
22	positive regulation of icosanoid secretion (GO:0032305)	3.72510296
23	chaperone-mediated protein transport (GO:0072321)	3.70330738
24	positive regulation of humoral immune response (GO:0002922)	3.69350806
25	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.65490739
26	positive regulation of fatty acid transport (GO:2000193)	3.65249033
27	ribosomal large subunit biogenesis (GO:0042273)	3.59559351
28	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.58942712
29	rRNA modification (GO:0000154)	3.57177166
30	electron transport chain (GO:0022900)	3.50591044
31	respiratory electron transport chain (GO:0022904)	3.49522478
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.42523283
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.42523283
34	NADH dehydrogenase complex assembly (GO:0010257)	3.42523283
35	positive regulation of osteoclast differentiation (GO:0045672)	3.38131354
36	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.35069357
37	GTP biosynthetic process (GO:0006183)	3.33532861
38	ribosomal small subunit biogenesis (GO:0042274)	3.30463400
39	pseudouridine synthesis (GO:0001522)	3.30228530
40	maturation of SSU-rRNA (GO:0030490)	3.29897233
41	viral transcription (GO:0019083)	3.28830951
42	proteasome assembly (GO:0043248)	3.27629363
43	protein complex biogenesis (GO:0070271)	3.27570558
44	regulation of inflammatory response to antigenic stimulus (GO:0002861)	3.24122020
45	inner mitochondrial membrane organization (GO:0007007)	3.22116825
46	rRNA processing (GO:0006364)	3.21059525
47	translational termination (GO:0006415)	3.20757371
48	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.18312529
49	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.18312529
50	rRNA metabolic process (GO:0016072)	3.18239496
51	rRNA methylation (GO:0031167)	3.17759323
52	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.16659523
53	urate metabolic process (GO:0046415)	3.15985472
54	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	3.15298999
55	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.14027158
56	ribonucleoprotein complex biogenesis (GO:0022613)	3.09619897
57	cotranslational protein targeting to membrane (GO:0006613)	3.08900289
58	protein targeting to ER (GO:0045047)	3.08021113
59	guanosine-containing compound biosynthetic process (GO:1901070)	3.06266122
60	cellular ketone body metabolic process (GO:0046950)	3.05119749
61	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.03012972
62	translation (GO:0006412)	3.02330373
63	translational elongation (GO:0006414)	3.02150319
64	water-soluble vitamin biosynthetic process (GO:0042364)	3.02040699
65	mitochondrial respiratory chain complex assembly (GO:0033108)	3.01242789
66	kynurenine metabolic process (GO:0070189)	3.01224445
67	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.98514529
68	GMP metabolic process (GO:0046037)	2.97135546
69	folic acid-containing compound biosynthetic process (GO:0009396)	2.96236591
70	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.95633573
71	regulation of cellular amino acid metabolic process (GO:0006521)	2.94272801
72	regulation of heat generation (GO:0031650)	2.94071493
73	IMP biosynthetic process (GO:0006188)	2.94027305
74	UTP biosynthetic process (GO:0006228)	2.94026372
75	protein localization to endoplasmic reticulum (GO:0070972)	2.93786361
76	UTP metabolic process (GO:0046051)	2.92644082
77	cellular component biogenesis (GO:0044085)	2.92225052
78	protein deneddylation (GO:0000338)	2.91779018
79	purine nucleobase biosynthetic process (GO:0009113)	2.90303936
80	ribosome biogenesis (GO:0042254)	2.89686092
81	cellular response to interleukin-15 (GO:0071350)	2.86705218
82	replication fork processing (GO:0031297)	2.86645172
83	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.85127766
84	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.83628247
85	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.83627574
86	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.82974517
87	regulation of defense response to virus by host (GO:0050691)	2.82339293
88	protein neddylation (GO:0045116)	2.81963434
89	adaptation of signaling pathway (GO:0023058)	2.80187084
90	maturation of 5.8S rRNA (GO:0000460)	2.79995923
91	regulation of activation of Janus kinase activity (GO:0010533)	2.78078373
92	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.76631694
93	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.76631694
94	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.76631694
95	signal peptide processing (GO:0006465)	2.73949358
96	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.73440358
97	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.73440358
98	regulation of immunoglobulin secretion (GO:0051023)	2.72244673
99	cullin deneddylation (GO:0010388)	2.70439527
100	cellular response to exogenous dsRNA (GO:0071360)	2.70275700

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.26822573
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.25340314
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.16286924
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.12125364
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.79230840
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.71286838
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.48134414
8	VDR_22108803_ChIP-Seq_LS180_Human	3.03618358
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.01694555
10	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.99663876
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.97694639
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.60771299
13	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.48532711
14	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.37464362
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.24017223
16	FOXP3_21729870_ChIP-Seq_TREG_Human	2.22059222
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.13322113
18	ZNF274_21170338_ChIP-Seq_K562_Hela	2.10590052
19	EZH2_22144423_ChIP-Seq_EOC_Human	2.08572403
20	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.97591341
21	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.96061591
22	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.93264941
23	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.83610505
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.80797003
25	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.79736235
26	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.78840783
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.77530949
28	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.75169620
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.74570372
30	DCP1A_22483619_ChIP-Seq_HELA_Human	1.69481780
31	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.65731759
32	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.63374925
33	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.58601194
34	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.58312667
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.56229673
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.52997481
37	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.52685648
38	IGF1R_20145208_ChIP-Seq_DFB_Human	1.51113635
39	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.50183492
40	TTF2_22483619_ChIP-Seq_HELA_Human	1.44941274
41	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.43483545
42	XRN2_22483619_ChIP-Seq_HELA_Human	1.42231503
43	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.40611923
44	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.40371067
45	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.39667950
46	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.38760730
47	GATA3_26560356_Chip-Seq_TH2_Human	1.38521471
48	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.36812992
49	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.34911005
50	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34075485
51	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.33100551
52	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.32422947
53	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.32128682
54	GABP_19822575_ChIP-Seq_HepG2_Human	1.31286121
55	ER_23166858_ChIP-Seq_MCF-7_Human	1.30315675
56	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.26424283
57	EWS_26573619_Chip-Seq_HEK293_Human	1.19293790
58	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.18419393
59	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.17613655
60	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.16963505
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.15559873
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.15559873
63	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.15276394
64	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.14939408
65	TAF2_19829295_ChIP-Seq_ESCs_Human	1.14713598
66	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.10581897
67	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.10460657
68	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.09183578
69	AR_20517297_ChIP-Seq_VCAP_Human	1.08239946
70	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.07086360
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06857367
72	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.06113864
73	CIITA_25753668_ChIP-Seq_RAJI_Human	1.03943543
74	KDM5A_27292631_Chip-Seq_BREAST_Human	1.03409416
75	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.03061509
76	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.01154709
77	NCOR_22424771_ChIP-Seq_293T_Human	0.98512490
78	E2F7_22180533_ChIP-Seq_HELA_Human	0.96498140
79	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95756461
80	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.95098750
81	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.94839669
82	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94673267
83	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.93531871
84	STAT1_20625510_ChIP-Seq_HELA_Human	0.93399580
85	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.93314302
86	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.89754046
87	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.89412398
88	OCT4_20526341_ChIP-Seq_ESCs_Human	0.89208296
89	PHF8_20622853_ChIP-Seq_HELA_Human	0.88247430
90	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.87177684
91	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.86796344
92	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86140228
93	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.86096336
94	IRF1_19129219_ChIP-ChIP_H3396_Human	0.85939900
95	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.85935289
96	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.85838330
97	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.85080166
98	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.84791775
99	HOXB7_26014856_ChIP-Seq_BT474_Human	0.84743549
100	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.84604019

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.25911378
2	MP0000685_abnormal_immune_system	4.25671926
3	MP0003436_decreased_susceptibility_to	2.68680877
4	MP0008877_abnormal_DNA_methylation	2.65062352
5	MP0002102_abnormal_ear_morphology	2.55408413
6	MP0003195_calcinosis	2.36260625
7	MP0002148_abnormal_hypersensitivity_rea	2.34049037
8	MP0009379_abnormal_foot_pigmentation	2.30254812
9	MP0001835_abnormal_antigen_presentation	2.29039027
10	MP0008058_abnormal_DNA_repair	2.24641259
11	MP0002876_abnormal_thyroid_physiology	2.23768298
12	MP0006292_abnormal_olfactory_placode	2.22268208
13	MP0002163_abnormal_gland_morphology	2.15238169
14	MP0000372_irregular_coat_pigmentation	2.09038142
15	MP0004885_abnormal_endolymph	2.03163666
16	MP0004145_abnormal_muscle_electrophysio	2.02617927
17	MP0003646_muscle_fatigue	1.98465967
18	MP0009785_altered_susceptibility_to	1.87763939
19	MP0005387_immune_system_phenotype	1.85270285
20	MP0001790_abnormal_immune_system	1.85270285
21	MP0005379_endocrine/exocrine_gland_phen	1.83182794
22	MP0008875_abnormal_xenobiotic_pharmacok	1.83062232
23	MP0002736_abnormal_nociception_after	1.73088273
24	MP0004147_increased_porphyrin_level	1.72572259
25	MP0001968_abnormal_touch/_nociception	1.72162729
26	MP0002006_tumorigenesis	1.71143057
27	MP0001348_abnormal_lacrimal_gland	1.66399164
28	MP0006035_abnormal_mitochondrial_morpho	1.65795455
29	MP0008789_abnormal_olfactory_epithelium	1.62876871
30	MP0001501_abnormal_sleep_pattern	1.61906798
31	MP0005377_hearing/vestibular/ear_phenot	1.59953898
32	MP0003878_abnormal_ear_physiology	1.59953898
33	MP0006036_abnormal_mitochondrial_physio	1.57306817
34	MP0001502_abnormal_circadian_rhythm	1.56502130
35	MP0010094_abnormal_chromosome_stability	1.55410027
36	MP0003806_abnormal_nucleotide_metabolis	1.53891486
37	MP0005000_abnormal_immune_tolerance	1.51591500
38	MP0003866_abnormal_defecation	1.48003721
39	MP0003879_abnormal_hair_cell	1.47366932
40	MP0002166_altered_tumor_susceptibility	1.46043249
41	MP0005551_abnormal_eye_electrophysiolog	1.42570778
42	MP0002160_abnormal_reproductive_system	1.42240217
43	MP0002090_abnormal_vision	1.41821579
44	MP0001919_abnormal_reproductive_system	1.41427351
45	MP0008872_abnormal_physiological_respon	1.39272578
46	MP0001800_abnormal_humoral_immune	1.38495876
47	MP0003786_premature_aging	1.37947088
48	MP0009764_decreased_sensitivity_to	1.37127971
49	MP0005389_reproductive_system_phenotype	1.34159546
50	MP0001984_abnormal_olfaction	1.30973141
51	MP0003763_abnormal_thymus_physiology	1.29215601
52	MP0002405_respiratory_system_inflammati	1.28388202
53	MP0003693_abnormal_embryo_hatching	1.27917742
54	MP0001986_abnormal_taste_sensitivity	1.23189932
55	MP0002234_abnormal_pharynx_morphology	1.20863939
56	MP0002254_reproductive_system_inflammat	1.20337784
57	MP0002723_abnormal_immune_serum	1.19960598
58	MP0002420_abnormal_adaptive_immunity	1.16099795
59	MP0001819_abnormal_immune_cell	1.15736636
60	MP0001873_stomach_inflammation	1.12826155
61	MP0001346_abnormal_lacrimal_gland	1.12079619
62	MP0006072_abnormal_retinal_apoptosis	1.10572040
63	MP0005646_abnormal_pituitary_gland	1.10417617
64	MP0002095_abnormal_skin_pigmentation	1.08593181
65	MP0000427_abnormal_hair_cycle	1.07839400
66	MP0004381_abnormal_hair_follicle	1.06216784
67	MP0005310_abnormal_salivary_gland	1.06071844
68	MP0002837_dystrophic_cardiac_calcinosis	1.05907772
69	MP0008057_abnormal_DNA_replication	1.03471466
70	MP0005645_abnormal_hypothalamus_physiol	1.02599202
71	MP0003111_abnormal_nucleus_morphology	1.01077613
72	MP0002277_abnormal_respiratory_mucosa	1.00606514
73	MP0000703_abnormal_thymus_morphology	0.99934682
74	MP0005075_abnormal_melanosome_morpholog	0.97893165
75	MP0002452_abnormal_antigen_presenting	0.97528659
76	MP0001881_abnormal_mammary_gland	0.96835759
77	MP0002138_abnormal_hepatobiliary_system	0.95428082
78	MP0002398_abnormal_bone_marrow	0.95337181
79	MP0005499_abnormal_olfactory_system	0.94988834
80	MP0005394_taste/olfaction_phenotype	0.94988834
81	MP0000716_abnormal_immune_system	0.93648844
82	MP0005025_abnormal_response_to	0.91555342
83	MP0002722_abnormal_immune_system	0.89563895
84	MP0002693_abnormal_pancreas_physiology	0.89560647
85	MP0005165_increased_susceptibility_to	0.85361977
86	MP0005448_abnormal_energy_balance	0.83337071
87	MP0005647_abnormal_sex_gland	0.82281250
88	MP0000647_abnormal_sebaceous_gland	0.81234434
89	MP0004142_abnormal_muscle_tone	0.80940826
90	MP0002938_white_spotting	0.80270852
91	MP0003950_abnormal_plasma_membrane	0.79821194
92	MP0005084_abnormal_gallbladder_morpholo	0.77488181
93	MP0001533_abnormal_skeleton_physiology	0.76157468
94	MP0001944_abnormal_pancreas_morphology	0.76153726
95	MP0001845_abnormal_inflammatory_respons	0.75364514
96	MP0002419_abnormal_innate_immunity	0.75245473
97	MP0003718_maternal_effect	0.75136572
98	MP0002429_abnormal_blood_cell	0.74439268
99	MP0001905_abnormal_dopamine_level	0.74167644
100	MP0000689_abnormal_spleen_morphology	0.72029152

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.61221488
2	Visual hallucinations (HP:0002367)	4.50832734
3	Autoimmune thrombocytopenia (HP:0001973)	4.23397877
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.15528644
5	Increased neuronal autofluorescent lipopigment (HP:0002074)	4.10112645
6	Mitochondrial inheritance (HP:0001427)	4.01667521
7	Acute encephalopathy (HP:0006846)	3.95618050
8	Increased CSF lactate (HP:0002490)	3.88778931
9	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	3.81270253
10	Increased density of long bones (HP:0006392)	3.72691224
11	Progressive macrocephaly (HP:0004481)	3.70371511
12	Hepatocellular necrosis (HP:0001404)	3.67109788
13	Testicular atrophy (HP:0000029)	3.66432901
14	Autoimmune hemolytic anemia (HP:0001890)	3.55019245
15	3-Methylglutaconic aciduria (HP:0003535)	3.26560147
16	Hepatic necrosis (HP:0002605)	3.22330617
17	Increased cerebral lipofuscin (HP:0011813)	3.18442927
18	Increased hepatocellular lipid droplets (HP:0006565)	3.17445270
19	Cerebral edema (HP:0002181)	3.13910722
20	Congenital stationary night blindness (HP:0007642)	3.03474594
21	Abnormality of the renal cortex (HP:0011035)	3.03354199
22	Premature loss of primary teeth (HP:0006323)	3.01484581
23	Abnormality of T cell physiology (HP:0011840)	2.98854400
24	Increased serum lactate (HP:0002151)	2.96548394
25	Dyschromatopsia (HP:0007641)	2.95997370
26	Lipid accumulation in hepatocytes (HP:0006561)	2.94883115
27	Prostate neoplasm (HP:0100787)	2.85169675
28	Optic disc pallor (HP:0000543)	2.84705596
29	Abnormality of T cells (HP:0002843)	2.81584006
30	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.79550576
31	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.79550576
32	Optic neuritis (HP:0100653)	2.71583907
33	Retrobulbar optic neuritis (HP:0100654)	2.71583907
34	Tetraparesis (HP:0002273)	2.68475608
35	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.61259443
36	IgG deficiency (HP:0004315)	2.60414308
37	Abnormality of cells of the erythroid lineage (HP:0012130)	2.55225536
38	Asplenia (HP:0001746)	2.54801588
39	Abnormal number of erythroid precursors (HP:0012131)	2.53916328
40	Increased intramyocellular lipid droplets (HP:0012240)	2.48445710
41	Lactic acidosis (HP:0003128)	2.47836456
42	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.41495148
43	Aplasia/hypoplasia of the uterus (HP:0008684)	2.37417324
44	Rhinitis (HP:0012384)	2.36161845
45	Parakeratosis (HP:0001036)	2.32708019
46	Renal Fanconi syndrome (HP:0001994)	2.31828778
47	Abnormal rod and cone electroretinograms (HP:0008323)	2.26712565
48	Gout (HP:0001997)	2.26443165
49	Macrocytic anemia (HP:0001972)	2.25944075
50	Pancytopenia (HP:0001876)	2.24993958
51	Renal cortical cysts (HP:0000803)	2.24605439
52	Keratoconjunctivitis (HP:0001096)	2.18235436
53	Respiratory failure (HP:0002878)	2.14469807
54	Abnormality of alanine metabolism (HP:0010916)	2.14081295
55	Hyperalaninemia (HP:0003348)	2.14081295
56	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.14081295
57	Lethargy (HP:0001254)	2.13034519
58	Type II lissencephaly (HP:0007260)	2.07294669
59	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.05809260
60	Central scotoma (HP:0000603)	2.04018393
61	Pancreatic cysts (HP:0001737)	2.04006258
62	Exercise intolerance (HP:0003546)	2.03721362
63	Increased muscle lipid content (HP:0009058)	2.02436072
64	Hypoplasia of the uterus (HP:0000013)	2.01807325
65	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.00649876
66	Abnormal albumin level (HP:0012116)	2.00139012
67	Hypoalbuminemia (HP:0003073)	2.00139012
68	Orchitis (HP:0100796)	1.99841127
69	Colon cancer (HP:0003003)	1.98272853
70	Reticulocytopenia (HP:0001896)	1.96205534
71	Anorexia (HP:0002039)	1.96126847
72	Pallor (HP:0000980)	1.95237236
73	Abnormality of the prostate (HP:0008775)	1.93705877
74	Abnormality of T cell number (HP:0011839)	1.93008586
75	Vasculitis (HP:0002633)	1.92229963
76	Abnormality of purine metabolism (HP:0004352)	1.91610297
77	Attenuation of retinal blood vessels (HP:0007843)	1.87972734
78	Lymphopenia (HP:0001888)	1.87080715
79	Severe combined immunodeficiency (HP:0004430)	1.85164208
80	Exertional dyspnea (HP:0002875)	1.84749990
81	Opisthotonus (HP:0002179)	1.84363416
82	Recurrent viral infections (HP:0004429)	1.83346951
83	Hepatosplenomegaly (HP:0001433)	1.83221975
84	Hypoproteinemia (HP:0003075)	1.82961371
85	Neutropenia (HP:0001875)	1.79382141
86	Abolished electroretinogram (ERG) (HP:0000550)	1.78916553
87	T lymphocytopenia (HP:0005403)	1.78461174
88	Congenital, generalized hypertrichosis (HP:0004540)	1.77345043
89	Spastic diplegia (HP:0001264)	1.73862054
90	Septo-optic dysplasia (HP:0100842)	1.72581712
91	Abnormality of cells of the lymphoid lineage (HP:0012140)	1.70427479
92	Pendular nystagmus (HP:0012043)	1.69858321
93	Tubulointerstitial fibrosis (HP:0005576)	1.68894711
94	Keratoconjunctivitis sicca (HP:0001097)	1.67996914
95	Constricted visual fields (HP:0001133)	1.67670770
96	Methylmalonic acidemia (HP:0002912)	1.66500481
97	Polyuria (HP:0000103)	1.65707533
98	Hemoptysis (HP:0002105)	1.62561549
99	Myositis (HP:0100614)	1.61523879
100	Hypomagnesemia (HP:0002917)	1.60341656

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.97580875
2	EIF2AK1	3.58979683
3	BCKDK	3.54564410
4	VRK2	3.37250607
5	NEK1	3.30446717
6	TAOK3	2.78816978
7	BMPR2	2.51140676
8	EIF2AK3	2.31575748
9	BUB1	2.29023660
10	TSSK6	2.25741577
11	MAP4K1	2.25110310
12	TLK1	2.21890880
13	ADRBK2	2.06357390
14	NUAK1	1.96332225
15	ZAK	1.89152371
16	GRK1	1.83193321
17	IKBKB	1.77973933
18	STK16	1.75235132
19	MAP2K6	1.68306286
20	NME2	1.63058429
21	WNK4	1.36821668
22	SRPK1	1.35918063
23	VRK1	1.35911650
24	PASK	1.35168746
25	DAPK1	1.29345188
26	EIF2AK2	1.26526558
27	FRK	1.26329910
28	MAP3K14	1.25811327
29	MAPKAPK3	1.23552449
30	MST4	1.21734712
31	PDK2	1.11151135
32	MAP3K13	1.10614597
33	GRK6	1.09075399
34	TAF1	1.05717282
35	OXSR1	1.04450776
36	PHKG2	1.01383388
37	PHKG1	1.01383388
38	CSNK1G3	1.01019777
39	KDR	0.99532471
40	PLK3	0.97867620
41	INSRR	0.97006217
42	FES	0.91242540
43	PRKCQ	0.90804431
44	CSNK1A1L	0.88582710
45	STK39	0.87048738
46	MAP3K12	0.86722331
47	CAMKK2	0.86550886
48	CDC7	0.86528902
49	NME1	0.78940902
50	AKT3	0.78409974
51	PRKCG	0.77083381
52	MAP2K2	0.75442235
53	CSNK1G2	0.73975313
54	CSNK1G1	0.70001384
55	CSNK1A1	0.67806220
56	PLK1	0.66382265
57	GRK7	0.65169699
58	CDC42BPA	0.64362097
59	ATR	0.64226682
60	CSNK2A2	0.64101415
61	CAMK2D	0.63194253
62	PAK3	0.61805029
63	ALK	0.60636793
64	SYK	0.60397511
65	CAMK2G	0.60277450
66	MYLK	0.59824790
67	PLK2	0.59749223
68	ADRBK1	0.59574022
69	TRIM28	0.59292401
70	PRKCI	0.58800334
71	PIK3CA	0.55843024
72	MUSK	0.55634826
73	CSNK2A1	0.54598154
74	WEE1	0.52455595
75	PLK4	0.51840755
76	KIT	0.51432518
77	ACVR1B	0.50519389
78	ITK	0.50420232
79	MAP4K2	0.48984575
80	GRK5	0.48361883
81	JAK3	0.46878351
82	RPS6KB1	0.46091897
83	MAPKAPK5	0.45506041
84	DYRK2	0.44950393
85	TIE1	0.43927963
86	CHEK2	0.42665614
87	AURKB	0.42194899
88	STK4	0.41708385
89	RPS6KB2	0.41321428
90	WNK1	0.40373488
91	CSNK1E	0.39599783
92	SMG1	0.39590301
93	AURKA	0.38545642
94	PRKCD	0.38519840
95	BRAF	0.37721296
96	LCK	0.37409143
97	IGF1R	0.36947611
98	PNCK	0.36657326
99	CAMK2A	0.35329298
100	LRRK2	0.35124871

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.99538436
2	Proteasome_Homo sapiens_hsa03050	3.95021828
3	Ribosome_Homo sapiens_hsa03010	3.60358831
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.29452310
5	Parkinsons disease_Homo sapiens_hsa05012	2.76452689
6	One carbon pool by folate_Homo sapiens_hsa00670	2.71964523
7	RNA polymerase_Homo sapiens_hsa03020	2.52832998
8	Mismatch repair_Homo sapiens_hsa03430	2.32735843
9	Homologous recombination_Homo sapiens_hsa03440	2.26674592
10	Primary immunodeficiency_Homo sapiens_hsa05340	2.00263343
11	Protein export_Homo sapiens_hsa03060	2.00133862
12	Huntingtons disease_Homo sapiens_hsa05016	1.93951049
13	Alzheimers disease_Homo sapiens_hsa05010	1.92073240
14	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.90647164
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.85279660
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.83851598
17	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.80435117
18	Asthma_Homo sapiens_hsa05310	1.74324436
19	DNA replication_Homo sapiens_hsa03030	1.69760690
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.68438975
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.65168744
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.62333286
23	RNA degradation_Homo sapiens_hsa03018	1.59306332
24	Pyrimidine metabolism_Homo sapiens_hsa00240	1.57498840
25	Type I diabetes mellitus_Homo sapiens_hsa04940	1.51412374
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.49944903
27	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.39494341
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.38915128
29	Purine metabolism_Homo sapiens_hsa00230	1.37042058
30	Cardiac muscle contraction_Homo sapiens_hsa04260	1.36339081
31	Caffeine metabolism_Homo sapiens_hsa00232	1.35355244
32	Basal transcription factors_Homo sapiens_hsa03022	1.33754211
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.31646554
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.31091954
35	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.27682485
36	Phototransduction_Homo sapiens_hsa04744	1.20289181
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.18145609
38	Allograft rejection_Homo sapiens_hsa05330	1.17903576
39	Propanoate metabolism_Homo sapiens_hsa00640	1.17836420
40	Antigen processing and presentation_Homo sapiens_hsa04612	1.14849049
41	Spliceosome_Homo sapiens_hsa03040	1.14423723
42	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.14029009
43	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.08741552
44	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.05347250
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.03077868
46	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.99325505
47	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.94910951
48	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.91643536
49	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.91311488
50	Butanoate metabolism_Homo sapiens_hsa00650	0.91037033
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.90057910
52	Graft-versus-host disease_Homo sapiens_hsa05332	0.86893871
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.84652784
54	RNA transport_Homo sapiens_hsa03013	0.84228374
55	Linoleic acid metabolism_Homo sapiens_hsa00591	0.83894448
56	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.83770125
57	Base excision repair_Homo sapiens_hsa03410	0.78161828
58	Phenylalanine metabolism_Homo sapiens_hsa00360	0.77391186
59	Non-homologous end-joining_Homo sapiens_hsa03450	0.75446580
60	Sulfur metabolism_Homo sapiens_hsa00920	0.71671846
61	Metabolic pathways_Homo sapiens_hsa01100	0.69121770
62	Rheumatoid arthritis_Homo sapiens_hsa05323	0.68512044
63	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.68278509
64	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.67238333
65	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.64582877
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.60313726
67	Peroxisome_Homo sapiens_hsa04146	0.58658195
68	Steroid biosynthesis_Homo sapiens_hsa00100	0.56756901
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.56324250
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.55678880
71	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.53565177
72	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.52677513
73	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.51332694
74	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.50698421
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49353131
76	Selenocompound metabolism_Homo sapiens_hsa00450	0.48341915
77	Tyrosine metabolism_Homo sapiens_hsa00350	0.47177937
78	Herpes simplex infection_Homo sapiens_hsa05168	0.47142361
79	Ether lipid metabolism_Homo sapiens_hsa00565	0.46098934
80	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.45023493
81	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.43089916
82	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.40614766
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.36756374
84	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.36024121
85	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.31079112
86	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.30721485
87	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.30192672
88	Folate biosynthesis_Homo sapiens_hsa00790	0.29480197
89	Chemical carcinogenesis_Homo sapiens_hsa05204	0.28477153
90	Retinol metabolism_Homo sapiens_hsa00830	0.27479393
91	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.26989689
92	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.26474019
93	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.25801003
94	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.25517251
95	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.23152022
96	Mineral absorption_Homo sapiens_hsa04978	0.22738739
97	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.22527681
98	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.20514018
99	Taste transduction_Homo sapiens_hsa04742	0.19624395
100	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.18391272

RPS26P55

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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