ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cytidine metabolic process (GO:0046087)	7.97575475
2	cytidine catabolic process (GO:0006216)	7.97575475
3	cytidine deamination (GO:0009972)	7.97575475
4	DNA deamination (GO:0045006)	7.93571730
5	pyrimidine ribonucleoside catabolic process (GO:0046133)	7.15098282
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	7.11022230
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.88359582
8	ATP synthesis coupled proton transport (GO:0015986)	4.86203938
9	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.86203938
10	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.74460087
11	regulation of regulatory T cell differentiation (GO:0045589)	4.59105651
12	protein neddylation (GO:0045116)	4.49813008
13	respiratory electron transport chain (GO:0022904)	4.48527296
14	electron transport chain (GO:0022900)	4.44774634
15	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.33683075
16	negative regulation by host of viral transcription (GO:0043922)	4.27544703
17	chaperone-mediated protein transport (GO:0072321)	4.17929556
18	ribosomal small subunit assembly (GO:0000028)	4.16511997
19	eosinophil chemotaxis (GO:0048245)	4.12981717
20	positive thymic T cell selection (GO:0045059)	4.06048127
21	protein complex biogenesis (GO:0070271)	4.02543464
22	platelet dense granule organization (GO:0060155)	3.95590500
23	sequestering of actin monomers (GO:0042989)	3.94350970
24	termination of RNA polymerase III transcription (GO:0006386)	3.84843960
25	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.84843960
26	positive T cell selection (GO:0043368)	3.81129634
27	respiratory chain complex IV assembly (GO:0008535)	3.79315176
28	ribosomal small subunit biogenesis (GO:0042274)	3.75146255
29	eosinophil migration (GO:0072677)	3.73777702
30	mitochondrial respiratory chain complex assembly (GO:0033108)	3.68611551
31	cellular response to interleukin-15 (GO:0071350)	3.66136334
32	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.65987087
33	cytochrome complex assembly (GO:0017004)	3.65286159
34	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.61755112
35	metallo-sulfur cluster assembly (GO:0031163)	3.59820272
36	iron-sulfur cluster assembly (GO:0016226)	3.59820272
37	maturation of SSU-rRNA (GO:0030490)	3.58575691
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.54405925
39	NADH dehydrogenase complex assembly (GO:0010257)	3.54405925
40	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.54405925
41	protein-cofactor linkage (GO:0018065)	3.51231836
42	pyrimidine nucleoside catabolic process (GO:0046135)	3.46927345
43	positive regulation of T cell apoptotic process (GO:0070234)	3.44011711
44	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.40381823
45	negative regulation of T cell apoptotic process (GO:0070233)	3.38887572
46	positive regulation of calcium-mediated signaling (GO:0050850)	3.38110080
47	positive regulation of interleukin-8 secretion (GO:2000484)	3.35525077
48	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.27790018
49	hydrogen ion transmembrane transport (GO:1902600)	3.25769790
50	T cell migration (GO:0072678)	3.25389878
51	DNA demethylation (GO:0080111)	3.24730508
52	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.23304223
53	positive regulation of defense response to virus by host (GO:0002230)	3.22581825
54	viral transcription (GO:0019083)	3.21150915
55	cytolysis (GO:0019835)	3.17808980
56	positive regulation of gamma-delta T cell activation (GO:0046645)	3.10380326
57	translational termination (GO:0006415)	3.06724078
58	proton transport (GO:0015992)	3.06606004
59	translational elongation (GO:0006414)	3.06340429
60	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.03480030
61	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.03480030
62	hydrogen transport (GO:0006818)	3.01543363
63	regulation of leukocyte mediated cytotoxicity (GO:0001910)	3.00829460
64	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.98833406
65	response to interleukin-15 (GO:0070672)	2.98665439
66	negative regulation of T cell differentiation in thymus (GO:0033085)	2.96590734
67	regulation of mitochondrial translation (GO:0070129)	2.96238179
68	regulation of natural killer cell mediated immunity (GO:0002715)	2.95410514
69	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	2.95410514
70	positive regulation of cell killing (GO:0031343)	2.93423287
71	adaptation of signaling pathway (GO:0023058)	2.93089364
72	ATP biosynthetic process (GO:0006754)	2.88619667
73	monocyte chemotaxis (GO:0002548)	2.86191590
74	regulation of T cell tolerance induction (GO:0002664)	2.85935294
75	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	2.85156842
76	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.84508393
77	ncRNA 3-end processing (GO:0043628)	2.83311608
78	positive regulation of tolerance induction (GO:0002645)	2.81710388
79	positive regulation of T cell chemotaxis (GO:0010820)	2.80915347
80	regulation of T cell chemotaxis (GO:0010819)	2.80915347
81	intracellular protein transmembrane import (GO:0044743)	2.80535596
82	regulation of lymphocyte chemotaxis (GO:1901623)	2.79942162
83	cotranslational protein targeting to membrane (GO:0006613)	2.79556106
84	thymic T cell selection (GO:0045061)	2.78692991
85	inner mitochondrial membrane organization (GO:0007007)	2.77938002
86	protein targeting to ER (GO:0045047)	2.77175453
87	regulation of gamma-delta T cell differentiation (GO:0045586)	2.74228218
88	rRNA modification (GO:0000154)	2.72885695
89	regulation of T cell receptor signaling pathway (GO:0050856)	2.70599605
90	regulation of T cell mediated cytotoxicity (GO:0001914)	2.70596389
91	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.70531525
92	regulation of chronic inflammatory response (GO:0002676)	2.69771205
93	ubiquinone biosynthetic process (GO:0006744)	2.69393994
94	macrophage chemotaxis (GO:0048246)	2.68886714
95	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.68733046
96	negative regulation of interleukin-1 beta production (GO:0032691)	2.67222608
97	regulation of T cell apoptotic process (GO:0070232)	2.67201849
98	negative T cell selection (GO:0043383)	2.66262406
99	regulation of cell killing (GO:0031341)	2.64933282
100	behavioral response to nicotine (GO:0035095)	2.64899788

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.92246656
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.88472517
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.19412704
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.50407875
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.44960154
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.36290483
7	ZNF274_21170338_ChIP-Seq_K562_Hela	3.06149284
8	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.90944665
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.88409934
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.86888916
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.84030040
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.83384739
13	VDR_22108803_ChIP-Seq_LS180_Human	2.62316677
14	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.38029790
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.25683198
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.25209523
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.25163440
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.80570702
19	FOXP3_21729870_ChIP-Seq_TREG_Human	1.79022007
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.71673666
21	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.64983448
22	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.54791693
23	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.52916820
24	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.46359554
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.43555528
26	IGF1R_20145208_ChIP-Seq_DFB_Human	1.43163183
27	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.43159163
28	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.41015120
29	GATA3_26560356_Chip-Seq_TH2_Human	1.40841159
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.38947998
31	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.37965700
32	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.36861565
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.36619435
34	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.33298637
35	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.33041075
36	MYB_26560356_Chip-Seq_TH2_Human	1.31917380
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.30480546
38	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.30282337
39	CTCF_20526341_ChIP-Seq_ESCs_Human	1.28325039
40	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.28297578
41	HTT_18923047_ChIP-ChIP_STHdh_Human	1.28015735
42	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.26762370
43	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.26728342
44	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.25805275
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.25750583
46	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.24551920
47	MYC_18940864_ChIP-ChIP_HL60_Human	1.24285578
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.20040062
49	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.16241737
50	TAF2_19829295_ChIP-Seq_ESCs_Human	1.16170363
51	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.15534338
52	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.14567762
53	BCL6_27268052_Chip-Seq_Bcells_Human	1.13721617
54	NANOG_20526341_ChIP-Seq_ESCs_Human	1.13414476
55	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.13389182
56	NCOR_22424771_ChIP-Seq_293T_Human	1.09978061
57	AR_20517297_ChIP-Seq_VCAP_Human	1.09931858
58	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.09930913
59	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.09426131
60	ER_23166858_ChIP-Seq_MCF-7_Human	1.08590083
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.08531558
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.08531558
63	GATA3_27048872_Chip-Seq_THYMUS_Human	1.08494050
64	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.07844166
65	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07194032
66	P300_27268052_Chip-Seq_Bcells_Human	1.05755516
67	CIITA_25753668_ChIP-Seq_RAJI_Human	1.02833917
68	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.02172024
69	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.01806314
70	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.00391684
71	GBX2_23144817_ChIP-Seq_PC3_Human	0.99905514
72	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.99737520
73	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99496745
74	RUNX_20019798_ChIP-Seq_JUKART_Human	0.98923722
75	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.98729565
76	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.97852339
77	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.97195205
78	ELK1_19687146_ChIP-ChIP_HELA_Human	0.97108131
79	ERA_21632823_ChIP-Seq_H3396_Human	0.94681088
80	MAF_26560356_Chip-Seq_TH2_Human	0.94295035
81	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.94125251
82	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.93656695
83	TTF2_22483619_ChIP-Seq_HELA_Human	0.93103915
84	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.92520764
85	GABP_19822575_ChIP-Seq_HepG2_Human	0.91637054
86	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.91450458
87	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.90857364
88	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.90316371
89	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.88301870
90	STAT1_20625510_ChIP-Seq_HELA_Human	0.87969564
91	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.87271772
92	UTX_26944678_Chip-Seq_JUKART_Human	0.86726065
93	MYC_19829295_ChIP-Seq_ESCs_Human	0.86368806
94	P53_21459846_ChIP-Seq_SAOS-2_Human	0.86237621
95	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.85946335
96	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.85513060
97	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.85461145
98	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.85141263
99	AR_21572438_ChIP-Seq_LNCaP_Human	0.83664960
100	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.83546634

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	5.53165370
2	MP0003866_abnormal_defecation	2.63896652
3	MP0005075_abnormal_melanosome_morpholog	2.43352708
4	MP0004145_abnormal_muscle_electrophysio	2.38388152
5	MP0009785_altered_susceptibility_to	2.33221846
6	MP0008872_abnormal_physiological_respon	2.17618784
7	MP0003763_abnormal_thymus_physiology	2.11917388
8	MP0000372_irregular_coat_pigmentation	2.11066457
9	MP0009379_abnormal_foot_pigmentation	2.07620077
10	MP0000569_abnormal_digit_pigmentation	1.97364102
11	MP0003011_delayed_dark_adaptation	1.97022180
12	MP0002163_abnormal_gland_morphology	1.93990213
13	MP0003786_premature_aging	1.87869347
14	MP0009333_abnormal_splenocyte_physiolog	1.81051779
15	MP0001919_abnormal_reproductive_system	1.80404659
16	MP0001800_abnormal_humoral_immune	1.79114116
17	MP0002638_abnormal_pupillary_reflex	1.76046221
18	MP0004147_increased_porphyrin_level	1.75165206
19	MP0006082_CNS_inflammation	1.73799003
20	MP0002876_abnormal_thyroid_physiology	1.67370085
21	MP0003045_fibrosis	1.63940546
22	MP0002102_abnormal_ear_morphology	1.62784921
23	MP0002736_abnormal_nociception_after	1.61102635
24	MP0002277_abnormal_respiratory_mucosa	1.60352588
25	MP0002723_abnormal_immune_serum	1.59026517
26	MP0005646_abnormal_pituitary_gland	1.57166529
27	MP0002822_catalepsy	1.56190411
28	MP0005000_abnormal_immune_tolerance	1.55725443
29	MP0001905_abnormal_dopamine_level	1.53551455
30	MP0002148_abnormal_hypersensitivity_rea	1.52726631
31	MP0006036_abnormal_mitochondrial_physio	1.51464542
32	MP0003787_abnormal_imprinting	1.50075052
33	MP0010155_abnormal_intestine_physiology	1.49474804
34	MP0005379_endocrine/exocrine_gland_phen	1.47376012
35	MP0002420_abnormal_adaptive_immunity	1.47319127
36	MP0005025_abnormal_response_to	1.45782070
37	MP0002933_joint_inflammation	1.45584966
38	MP0001819_abnormal_immune_cell	1.42221049
39	MP0009745_abnormal_behavioral_response	1.36808923
40	MP0002837_dystrophic_cardiac_calcinosis	1.36381041
41	MP0005645_abnormal_hypothalamus_physiol	1.35975582
42	MP0004142_abnormal_muscle_tone	1.33969789
43	MP0002234_abnormal_pharynx_morphology	1.33807831
44	MP0005389_reproductive_system_phenotype	1.32890590
45	MP0001968_abnormal_touch/_nociception	1.30670136
46	MP0001835_abnormal_antigen_presentation	1.27522828
47	MP0001873_stomach_inflammation	1.25759765
48	MP0006072_abnormal_retinal_apoptosis	1.24948394
49	MP0006035_abnormal_mitochondrial_morpho	1.24630075
50	MP0005387_immune_system_phenotype	1.23833224
51	MP0001790_abnormal_immune_system	1.23833224
52	MP0001984_abnormal_olfaction	1.21901839
53	MP0006276_abnormal_autonomic_nervous	1.19195518
54	MP0008875_abnormal_xenobiotic_pharmacok	1.16961346
55	MP0005377_hearing/vestibular/ear_phenot	1.16909646
56	MP0003878_abnormal_ear_physiology	1.16909646
57	MP0000703_abnormal_thymus_morphology	1.15051376
58	MP0008789_abnormal_olfactory_epithelium	1.14603896
59	MP0000716_abnormal_immune_system	1.14191988
60	MP0005551_abnormal_eye_electrophysiolog	1.13699174
61	MP0004742_abnormal_vestibular_system	1.12589873
62	MP0002452_abnormal_antigen_presenting	1.11586591
63	MP0001986_abnormal_taste_sensitivity	1.09649813
64	MP0005670_abnormal_white_adipose	1.09190000
65	MP0003646_muscle_fatigue	1.08993550
66	MP0005394_taste/olfaction_phenotype	1.08311027
67	MP0005499_abnormal_olfactory_system	1.08311027
68	MP0002095_abnormal_skin_pigmentation	1.07181169
69	MP0002398_abnormal_bone_marrow	1.05139343
70	MP0000685_abnormal_immune_system	1.03667900
71	MP0002405_respiratory_system_inflammati	0.98119223
72	MP0001845_abnormal_inflammatory_respons	0.95936696
73	MP0003195_calcinosis	0.94951341
74	MP0001529_abnormal_vocalization	0.94317906
75	MP0000689_abnormal_spleen_morphology	0.92958581
76	MP0003123_paternal_imprinting	0.91441555
77	MP0002722_abnormal_immune_system	0.90785349
78	MP0002160_abnormal_reproductive_system	0.90202003
79	MP0005253_abnormal_eye_physiology	0.89613177
80	MP0005174_abnormal_tail_pigmentation	0.89389784
81	MP0006292_abnormal_olfactory_placode	0.86723861
82	MP0001485_abnormal_pinna_reflex	0.85259457
83	MP0002735_abnormal_chemical_nociception	0.84455350
84	MP0005636_abnormal_mineral_homeostasis	0.81877728
85	MP0002429_abnormal_blood_cell	0.79984515
86	MP0002272_abnormal_nervous_system	0.79810594
87	MP0005623_abnormal_meninges_morphology	0.77145159
88	MP0001501_abnormal_sleep_pattern	0.74673321
89	MP0009765_abnormal_xenobiotic_induced	0.73119533
90	MP0008469_abnormal_protein_level	0.72882576
91	MP0003724_increased_susceptibility_to	0.72637339
92	MP0009763_increased_sensitivity_to	0.72630913
93	MP0002733_abnormal_thermal_nociception	0.72048920
94	MP0001765_abnormal_ion_homeostasis	0.71848456
95	MP0003567_abnormal_fetal_cardiomyocyte	0.70092383
96	MP0001348_abnormal_lacrimal_gland	0.69905430
97	MP0004885_abnormal_endolymph	0.69142765
98	MP0009046_muscle_twitch	0.68825989
99	MP0005310_abnormal_salivary_gland	0.67787307
100	MP0001663_abnormal_digestive_system	0.67253710

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of T cell number (HP:0011839)	4.59663997
2	Mitochondrial inheritance (HP:0001427)	4.51698948
3	Acute necrotizing encephalopathy (HP:0006965)	4.50495757
4	T lymphocytopenia (HP:0005403)	4.35561673
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.93501306
6	Congenital stationary night blindness (HP:0007642)	3.92833839
7	Hepatocellular necrosis (HP:0001404)	3.81428446
8	Increased CSF lactate (HP:0002490)	3.79040622
9	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.76728042
10	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.76728042
11	3-Methylglutaconic aciduria (HP:0003535)	3.69357487
12	Progressive macrocephaly (HP:0004481)	3.62858268
13	IgG deficiency (HP:0004315)	3.56292108
14	Acute encephalopathy (HP:0006846)	3.52098704
15	Hepatic necrosis (HP:0002605)	3.41699079
16	Aplastic anemia (HP:0001915)	3.31785078
17	Abnormality of T cells (HP:0002843)	3.14614181
18	Abnormal number of erythroid precursors (HP:0012131)	3.06411726
19	Increased hepatocellular lipid droplets (HP:0006565)	3.04399425
20	Increased intramyocellular lipid droplets (HP:0012240)	3.04013202
21	Severe combined immunodeficiency (HP:0004430)	2.97393067
22	Renal Fanconi syndrome (HP:0001994)	2.94043951
23	Abnormality of cells of the erythroid lineage (HP:0012130)	2.85965475
24	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.85720584
25	Cerebral edema (HP:0002181)	2.83489629
26	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.73042028
27	Hypoproteinemia (HP:0003075)	2.72166314
28	Pancreatic fibrosis (HP:0100732)	2.68853069
29	Autoimmune hemolytic anemia (HP:0001890)	2.67370175
30	Optic disc pallor (HP:0000543)	2.66709365
31	Type II lissencephaly (HP:0007260)	2.61374232
32	Pancreatic cysts (HP:0001737)	2.58737621
33	Abnormality of eosinophils (HP:0001879)	2.56656328
34	Renal cortical cysts (HP:0000803)	2.56594517
35	Abnormality of midbrain morphology (HP:0002418)	2.56259259
36	Molar tooth sign on MRI (HP:0002419)	2.56259259
37	Pendular nystagmus (HP:0012043)	2.53553031
38	Lipid accumulation in hepatocytes (HP:0006561)	2.48205807
39	Stomach cancer (HP:0012126)	2.45549296
40	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.38531897
41	Abnormality of the labia minora (HP:0012880)	2.36608608
42	Respiratory failure (HP:0002878)	2.35377171
43	Increased serum lactate (HP:0002151)	2.33890531
44	Lactic acidosis (HP:0003128)	2.33006844
45	Attenuation of retinal blood vessels (HP:0007843)	2.32893982
46	True hermaphroditism (HP:0010459)	2.32560598
47	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.30975687
48	Abnormality of the renal cortex (HP:0011035)	2.29587312
49	Increased muscle lipid content (HP:0009058)	2.27370167
50	Abnormality of B cell number (HP:0010975)	2.25860661
51	Abnormal rod and cone electroretinograms (HP:0008323)	2.25731946
52	Chronic diarrhea (HP:0002028)	2.23623965
53	Increased IgM level (HP:0003496)	2.23536308
54	Thyroiditis (HP:0100646)	2.22559486
55	Sclerocornea (HP:0000647)	2.16234412
56	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.15465443
57	Anencephaly (HP:0002323)	2.09178504
58	Combined immunodeficiency (HP:0005387)	2.06433759
59	Absent thumb (HP:0009777)	2.06199881
60	Medial flaring of the eyebrow (HP:0010747)	2.04850362
61	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.04503359
62	Amyotrophic lateral sclerosis (HP:0007354)	2.01640899
63	Abnormal protein glycosylation (HP:0012346)	2.00077464
64	Abnormal glycosylation (HP:0012345)	2.00077464
65	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.00077464
66	Abnormal protein N-linked glycosylation (HP:0012347)	2.00077464
67	Eosinophilia (HP:0001880)	1.98933720
68	Abnormality of T cell physiology (HP:0011840)	1.98925446
69	Retinal dysplasia (HP:0007973)	1.97100424
70	Ureteral stenosis (HP:0000071)	1.97034985
71	Macrocytic anemia (HP:0001972)	1.96262833
72	IgM deficiency (HP:0002850)	1.92065565
73	Elevated erythrocyte sedimentation rate (HP:0003565)	1.91806859
74	Hypoalbuminemia (HP:0003073)	1.91765341
75	Abnormal albumin level (HP:0012116)	1.91765341
76	Methylmalonic aciduria (HP:0012120)	1.90029541
77	Exercise intolerance (HP:0003546)	1.89754746
78	Type I transferrin isoform profile (HP:0003642)	1.89053373
79	Abnormality of magnesium homeostasis (HP:0004921)	1.84695943
80	Generalized aminoaciduria (HP:0002909)	1.84189307
81	Ureteral obstruction (HP:0006000)	1.83381405
82	Autoimmune thrombocytopenia (HP:0001973)	1.83030089
83	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.82892300
84	Pancytopenia (HP:0001876)	1.82109633
85	Lethargy (HP:0001254)	1.81877307
86	Bile duct proliferation (HP:0001408)	1.81738871
87	Abnormal biliary tract physiology (HP:0012439)	1.81738871
88	Hypochromic anemia (HP:0001931)	1.80030500
89	Emotional lability (HP:0000712)	1.77134216
90	Exertional dyspnea (HP:0002875)	1.76806039
91	Constricted visual fields (HP:0001133)	1.76352662
92	Hypomagnesemia (HP:0002917)	1.76249838
93	Progressive microcephaly (HP:0000253)	1.75394699
94	Abnormality of the prostate (HP:0008775)	1.75295023
95	Reticulocytopenia (HP:0001896)	1.74051918
96	Gastrointestinal infarctions (HP:0005244)	1.74013950
97	Abolished electroretinogram (ERG) (HP:0000550)	1.73866266
98	Severe visual impairment (HP:0001141)	1.73270719
99	Abnormality of renal resorption (HP:0011038)	1.70960774
100	Abnormality of macular pigmentation (HP:0008002)	1.68928745

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	5.60527939
2	PINK1	3.94379112
3	MAP4K2	3.91753217
4	KDR	3.89778041
5	TLK1	3.88329608
6	ZAK	3.56578431
7	BCKDK	2.78357205
8	INSRR	2.49915005
9	ITK	2.42947920
10	ADRBK2	2.41481229
11	TESK2	2.41170314
12	VRK2	1.98496640
13	LIMK1	1.93665216
14	VRK1	1.80856447
15	BUB1	1.66966283
16	MAP4K1	1.56984310
17	PIK3CA	1.44425379
18	NUAK1	1.40866139
19	WNK4	1.38695181
20	RPS6KA4	1.38222824
21	GRK6	1.37497369
22	GRK1	1.33160033
23	PDK2	1.28868963
24	ACVR1B	1.24437468
25	SYK	1.22981594
26	NME2	1.20269370
27	MST4	1.19405632
28	RPS6KA5	1.19019195
29	GRK7	1.18662762
30	CAMKK2	1.13378883
31	PASK	1.11335422
32	MAPK13	1.04941933
33	TNK2	1.00997521
34	PRKCQ	0.99758023
35	TEC	0.99533438
36	TRIM28	0.97891165
37	MAP3K12	0.97150750
38	CAMKK1	0.94445822
39	MAP3K11	0.93150418
40	FES	0.92988319
41	NME1	0.92822252
42	TAOK3	0.91898330
43	LCK	0.86927262
44	IKBKB	0.86883346
45	PIM1	0.83751435
46	MAPKAPK3	0.82703299
47	MATK	0.82075862
48	BMPR1B	0.80059477
49	BTK	0.77846640
50	TESK1	0.76860846
51	CSK	0.74262687
52	LYN	0.73402184
53	ZAP70	0.72401744
54	DAPK2	0.67413229
55	IRAK4	0.65518670
56	MARK1	0.64636621
57	ABL2	0.63355057
58	FRK	0.61401540
59	STK16	0.58251443
60	MAP2K2	0.56129882
61	DYRK2	0.53551219
62	BCR	0.52127725
63	OBSCN	0.50493893
64	CAMK1	0.48771298
65	CSNK1G2	0.47887999
66	MYLK	0.46384453
67	FYN	0.46211371
68	PRKCA	0.46076875
69	ADRBK1	0.45263884
70	PRKACA	0.44261818
71	JAK3	0.42639568
72	PIK3CG	0.41672568
73	DAPK1	0.40779646
74	PRKCG	0.39447704
75	WNK3	0.39107123
76	CSNK1A1	0.38996972
77	CSNK2A1	0.38087355
78	MARK3	0.37355913
79	NTRK2	0.36943137
80	CSNK1G3	0.35720560
81	MAPKAPK5	0.35590375
82	AURKA	0.35484235
83	TAOK2	0.34502304
84	NTRK1	0.33786002
85	IGF1R	0.33337736
86	TAOK1	0.33017807
87	KIT	0.32843877
88	STK39	0.32513693
89	IKBKE	0.31855606
90	TIE1	0.31295851
91	PRKCE	0.30259345
92	ILK	0.30129576
93	INSR	0.30014862
94	MAPK15	0.28793704
95	CAMK2A	0.28308092
96	ABL1	0.26242792
97	PRKCD	0.26150072
98	PRKCI	0.26114214
99	CSNK2A2	0.25342338
100	STK11	0.24863697

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.53571819
2	Primary immunodeficiency_Homo sapiens_hsa05340	4.19359324
3	Parkinsons disease_Homo sapiens_hsa05012	3.89301908
4	Ribosome_Homo sapiens_hsa03010	3.61305337
5	Proteasome_Homo sapiens_hsa03050	3.48150354
6	RNA polymerase_Homo sapiens_hsa03020	3.17149379
7	Alzheimers disease_Homo sapiens_hsa05010	2.57482709
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.47498898
9	Huntingtons disease_Homo sapiens_hsa05016	2.41962436
10	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.38762821
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.38559573
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.14489629
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.98284133
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.94582954
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.93922817
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.90421375
17	Allograft rejection_Homo sapiens_hsa05330	1.89179141
18	Protein export_Homo sapiens_hsa03060	1.78635938
19	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.64072394
20	Homologous recombination_Homo sapiens_hsa03440	1.60941270
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.59506912
22	Type I diabetes mellitus_Homo sapiens_hsa04940	1.58198059
23	Rheumatoid arthritis_Homo sapiens_hsa05323	1.57219649
24	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.56127410
25	Butanoate metabolism_Homo sapiens_hsa00650	1.37962656
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.33513075
27	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.30178754
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.25686555
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.24438400
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.17433254
31	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.13550194
32	Phototransduction_Homo sapiens_hsa04744	1.12106487
33	Caffeine metabolism_Homo sapiens_hsa00232	1.06199325
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.04871562
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02960597
36	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.95361893
37	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.95262189
38	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.93114784
39	Fanconi anemia pathway_Homo sapiens_hsa03460	0.92450736
40	Peroxisome_Homo sapiens_hsa04146	0.92360707
41	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.88988955
42	One carbon pool by folate_Homo sapiens_hsa00670	0.88709804
43	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.85029218
44	Purine metabolism_Homo sapiens_hsa00230	0.84401057
45	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.83824094
46	Retinol metabolism_Homo sapiens_hsa00830	0.83040950
47	Spliceosome_Homo sapiens_hsa03040	0.80191265
48	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.79290813
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.78522093
50	RNA degradation_Homo sapiens_hsa03018	0.78267117
51	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.77679408
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.75035567
53	Nicotine addiction_Homo sapiens_hsa05033	0.69018838
54	Basal transcription factors_Homo sapiens_hsa03022	0.68764410
55	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.68711319
56	Metabolic pathways_Homo sapiens_hsa01100	0.65993333
57	DNA replication_Homo sapiens_hsa03030	0.62481749
58	Sulfur relay system_Homo sapiens_hsa04122	0.62358368
59	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.62148463
60	Propanoate metabolism_Homo sapiens_hsa00640	0.61226680
61	Ether lipid metabolism_Homo sapiens_hsa00565	0.60751677
62	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.57831811
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.57431909
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.57338387
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57198995
66	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.53500948
67	Olfactory transduction_Homo sapiens_hsa04740	0.52719884
68	Mismatch repair_Homo sapiens_hsa03430	0.51921501
69	Viral myocarditis_Homo sapiens_hsa05416	0.48052923
70	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.47973009
71	Folate biosynthesis_Homo sapiens_hsa00790	0.47858025
72	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.46912386
73	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.46414054
74	Measles_Homo sapiens_hsa05162	0.43709487
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42438999
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.41731295
77	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.37623708
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.37615501
79	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.36836993
80	Asthma_Homo sapiens_hsa05310	0.36187056
81	Taste transduction_Homo sapiens_hsa04742	0.34103339
82	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.31765910
83	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.29668326
84	Base excision repair_Homo sapiens_hsa03410	0.28950809
85	Salmonella infection_Homo sapiens_hsa05132	0.28452251
86	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.26538282
87	Tyrosine metabolism_Homo sapiens_hsa00350	0.25602364
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.24183782
89	Salivary secretion_Homo sapiens_hsa04970	0.23613582
90	Fat digestion and absorption_Homo sapiens_hsa04975	0.22965852
91	Amphetamine addiction_Homo sapiens_hsa05031	0.16045778
92	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.15610484
93	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.15398205
94	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.15086733
95	RNA transport_Homo sapiens_hsa03013	0.14759115
96	Chemokine signaling pathway_Homo sapiens_hsa04062	0.14699582
97	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.13320035
98	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.12712614
99	Sulfur metabolism_Homo sapiens_hsa00920	0.12512697
100	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.12057956

RPS26P56

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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