RPS26P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)7.41504801
2cytidine metabolic process (GO:0046087)7.41504801
3cytidine catabolic process (GO:0006216)7.41504801
4DNA deamination (GO:0045006)7.04462147
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.35609331
6ribosomal small subunit assembly (GO:0000028)6.26532024
7pyrimidine ribonucleoside catabolic process (GO:0046133)6.25978166
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.80700674
9energy coupled proton transport, down electrochemical gradient (GO:0015985)5.21729821
10ATP synthesis coupled proton transport (GO:0015986)5.21729821
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.29384112
12respiratory electron transport chain (GO:0022904)4.18696557
13electron transport chain (GO:0022900)4.11568569
14proteasome assembly (GO:0043248)4.01768566
15positive regulation of calcium-mediated signaling (GO:0050850)3.92028105
16viral transcription (GO:0019083)3.87604576
17negative regulation of calcium ion transport into cytosol (GO:0010523)3.83744103
18ncRNA 3-end processing (GO:0043628)3.75108645
19pyrimidine nucleoside catabolic process (GO:0046135)3.69802868
20translational termination (GO:0006415)3.65240497
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.61876626
22T cell migration (GO:0072678)3.53313294
23protein targeting to ER (GO:0045047)3.52773654
24chaperone-mediated protein transport (GO:0072321)3.52385587
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.51781124
26cotranslational protein targeting to membrane (GO:0006613)3.46166279
27protein complex biogenesis (GO:0070271)3.44521444
28positive regulation of lamellipodium assembly (GO:0010592)3.44272520
29immunoglobulin mediated immune response (GO:0016064)3.42368797
30protein neddylation (GO:0045116)3.40802344
31protein localization to endoplasmic reticulum (GO:0070972)3.40190203
32establishment of protein localization to endoplasmic reticulum (GO:0072599)3.34307104
33Arp2/3 complex-mediated actin nucleation (GO:0034314)3.34211302
34eosinophil chemotaxis (GO:0048245)3.31917837
35translational elongation (GO:0006414)3.31705962
36positive thymic T cell selection (GO:0045059)3.28030264
37ribosomal small subunit biogenesis (GO:0042274)3.24681220
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.18454092
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.15348325
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.15348325
41NADH dehydrogenase complex assembly (GO:0010257)3.15348325
42regulation of interleukin-8 secretion (GO:2000482)3.13305912
43ATP biosynthetic process (GO:0006754)3.12694031
44activated T cell proliferation (GO:0050798)3.08476444
45cytolysis (GO:0019835)3.08216944
46positive regulation of T cell mediated cytotoxicity (GO:0001916)3.05189906
47actin nucleation (GO:0045010)3.04676382
48eosinophil migration (GO:0072677)3.03161291
49translation (GO:0006412)2.98533660
50regulation of calcium-mediated signaling (GO:0050848)2.97725820
51sequestering of actin monomers (GO:0042989)2.97412434
52response to pheromone (GO:0019236)2.96911650
53mitochondrial respiratory chain complex assembly (GO:0033108)2.95733029
54GPI anchor biosynthetic process (GO:0006506)2.93809130
55positive T cell selection (GO:0043368)2.90166252
56positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.84620460
57viral life cycle (GO:0019058)2.83620291
58GPI anchor metabolic process (GO:0006505)2.82554277
59negative regulation of mast cell activation (GO:0033004)2.82280382
60platelet dense granule organization (GO:0060155)2.79215062
61B cell mediated immunity (GO:0019724)2.75685225
62purine nucleoside triphosphate biosynthetic process (GO:0009145)2.72967781
63regulation of cellular amino acid metabolic process (GO:0006521)2.72563494
64translational initiation (GO:0006413)2.72469024
65purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.72201241
66negative regulation of viral genome replication (GO:0045071)2.70998272
672-deoxyribonucleotide biosynthetic process (GO:0009265)2.69371624
68deoxyribose phosphate biosynthetic process (GO:0046385)2.69371624
69cellular protein complex disassembly (GO:0043624)2.69323267
70negative regulation of T cell apoptotic process (GO:0070233)2.68929550
71activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.68508189
72regulation of activation of Janus kinase activity (GO:0010533)2.66612044
73response to interferon-beta (GO:0035456)2.66346742
74hydrogen ion transmembrane transport (GO:1902600)2.66313472
75regulation of T cell mediated cytotoxicity (GO:0001914)2.65822641
76T cell costimulation (GO:0031295)2.63281766
77deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.63221017
78autophagic vacuole fusion (GO:0000046)2.63199634
79icosanoid secretion (GO:0032309)2.61467286
80arachidonic acid secretion (GO:0050482)2.61467286
81positive regulation of T cell apoptotic process (GO:0070234)2.60340951
82lymphocyte costimulation (GO:0031294)2.60328177
83regulation of hypersensitivity (GO:0002883)2.60326484
84positive regulation of cell killing (GO:0031343)2.60208555
85protein polyglutamylation (GO:0018095)2.58748673
86protein peptidyl-prolyl isomerization (GO:0000413)2.58038337
87regulation of protein glycosylation (GO:0060049)2.57932195
88positive regulation of lamellipodium organization (GO:1902745)2.57567564
89negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.56458864
90oxidative phosphorylation (GO:0006119)2.56054196
91proton transport (GO:0015992)2.55804998
92protein-cofactor linkage (GO:0018065)2.52960400
93hydrogen transport (GO:0006818)2.52845597
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.52783225
95behavioral response to nicotine (GO:0035095)2.51756602
96positive regulation of interleukin-8 secretion (GO:2000484)2.51502626
97T cell receptor signaling pathway (GO:0050852)2.51123034
98DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.50322406
99regulation of leukocyte mediated cytotoxicity (GO:0001910)2.50125216
100organelle membrane fusion (GO:0090174)2.49459603

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.94143877
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.92350628
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.71940836
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.52599823
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.29412019
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.27638123
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.16195241
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.83220061
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.77424250
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.71604191
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.67045421
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.57735410
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.54983386
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.19938330
15VDR_23849224_ChIP-Seq_CD4+_Human2.16843829
16VDR_22108803_ChIP-Seq_LS180_Human2.10764307
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00390971
18ETS1_20019798_ChIP-Seq_JURKAT_Human1.95197942
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.94339535
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93835187
21IRF8_21731497_ChIP-ChIP_J774_Mouse1.88768820
22ZNF274_21170338_ChIP-Seq_K562_Hela1.80062695
23MYB_26560356_Chip-Seq_TH2_Human1.78077988
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77483632
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63041967
26EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.58465997
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53432857
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50365512
29GATA3_26560356_Chip-Seq_TH2_Human1.49690007
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48542545
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47702655
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.43587961
33FOXP3_21729870_ChIP-Seq_TREG_Human1.40359421
34PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.38870611
35CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36194762
36BCL6_27268052_Chip-Seq_Bcells_Human1.35615617
37CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34239657
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31068604
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.29529021
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27464624
41PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.27245961
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.26780604
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26515071
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.25967697
45TAF2_19829295_ChIP-Seq_ESCs_Human1.25949216
46MYC_18940864_ChIP-ChIP_HL60_Human1.25159336
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.24619006
48EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23194209
49EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.21160915
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19737808
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.19737808
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18609213
53CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17883425
54NANOG_19829295_ChIP-Seq_ESCs_Human1.17411630
55SOX2_19829295_ChIP-Seq_ESCs_Human1.17411630
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.17389719
57RUNX_20019798_ChIP-Seq_JUKART_Human1.16594359
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16367658
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.15981474
60GATA3_27048872_Chip-Seq_THYMUS_Human1.14626247
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13541787
62TP53_22573176_ChIP-Seq_HFKS_Human1.11465638
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10223153
64NANOG_20526341_ChIP-Seq_ESCs_Human1.09436313
65RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09040363
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08968091
67NCOR_22424771_ChIP-Seq_293T_Human1.08929873
68AR_20517297_ChIP-Seq_VCAP_Human1.08653741
69CIITA_25753668_ChIP-Seq_RAJI_Human1.06948148
70ELK1_19687146_ChIP-ChIP_HELA_Human1.06943548
71ERG_20517297_ChIP-Seq_VCAP_Human1.06109503
72HTT_18923047_ChIP-ChIP_STHdh_Human1.05629512
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04880870
74MYC_19829295_ChIP-Seq_ESCs_Human1.04669640
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04192861
76MYB_26560356_Chip-Seq_TH1_Human1.03902572
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03405191
78UTX_26944678_Chip-Seq_JUKART_Human1.01818659
79ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01789553
80FOXH1_21741376_ChIP-Seq_EPCs_Human1.01755170
81TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.00420856
82BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99430572
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98761285
84IGF1R_20145208_ChIP-Seq_DFB_Human0.97031339
85SPI1_23547873_ChIP-Seq_NB4_Human0.96435405
86IRF1_19129219_ChIP-ChIP_H3396_Human0.96410587
87ERA_21632823_ChIP-Seq_H3396_Human0.96307910
88CTCF_20526341_ChIP-Seq_ESCs_Human0.95558393
89FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94245069
90PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93204977
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93053795
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92667520
93BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91465276
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90613129
95CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90524964
96EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90436752
97GATA3_21867929_ChIP-Seq_TH1_Mouse0.89859057
98FLI1_27457419_Chip-Seq_LIVER_Mouse0.88829515
99SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88475671
100SA1_27219007_Chip-Seq_Bcells_Human0.88473379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.80639486
2MP0001835_abnormal_antigen_presentation3.04025581
3MP0009379_abnormal_foot_pigmentation2.87537251
4MP0009333_abnormal_splenocyte_physiolog2.85680210
5MP0005645_abnormal_hypothalamus_physiol2.75721539
6MP0009785_altered_susceptibility_to2.66693954
7MP0003646_muscle_fatigue2.44432310
8MP0006082_CNS_inflammation2.36294695
9MP0001800_abnormal_humoral_immune2.33825383
10MP0005000_abnormal_immune_tolerance2.30275194
11MP0003763_abnormal_thymus_physiology2.26027229
12MP0003806_abnormal_nucleotide_metabolis2.24760813
13MP0002933_joint_inflammation2.14474411
14MP0000372_irregular_coat_pigmentation2.13093557
15MP0002148_abnormal_hypersensitivity_rea2.07810915
16MP0002723_abnormal_immune_serum1.97679420
17MP0005025_abnormal_response_to1.97473660
18MP0005084_abnormal_gallbladder_morpholo1.95528430
19MP0001905_abnormal_dopamine_level1.92350868
20MP0008872_abnormal_physiological_respon1.88956272
21MP0002420_abnormal_adaptive_immunity1.84468994
22MP0002138_abnormal_hepatobiliary_system1.83595237
23MP0006292_abnormal_olfactory_placode1.78366586
24MP0001819_abnormal_immune_cell1.77690077
25MP0010386_abnormal_urinary_bladder1.77188828
26MP0002277_abnormal_respiratory_mucosa1.77168425
27MP0002452_abnormal_antigen_presenting1.75986002
28MP0003724_increased_susceptibility_to1.63008370
29MP0006036_abnormal_mitochondrial_physio1.62331541
30MP0005387_immune_system_phenotype1.58795876
31MP0001790_abnormal_immune_system1.58795876
32MP0004145_abnormal_muscle_electrophysio1.58644283
33MP0002166_altered_tumor_susceptibility1.58109369
34MP0003866_abnormal_defecation1.53094062
35MP0003787_abnormal_imprinting1.52625346
36MP0004147_increased_porphyrin_level1.51302291
37MP0000685_abnormal_immune_system1.50191196
38MP0000716_abnormal_immune_system1.43164292
39MP0002163_abnormal_gland_morphology1.38508652
40MP0005253_abnormal_eye_physiology1.36311985
41MP0008875_abnormal_xenobiotic_pharmacok1.35809212
42MP0002398_abnormal_bone_marrow1.34610484
43MP0002419_abnormal_innate_immunity1.33251505
44MP0001873_stomach_inflammation1.31199653
45MP0001845_abnormal_inflammatory_respons1.26261097
46MP0008995_early_reproductive_senescence1.23142329
47MP0003011_delayed_dark_adaptation1.21411933
48MP0010155_abnormal_intestine_physiology1.20620415
49MP0006072_abnormal_retinal_apoptosis1.18297054
50MP0008469_abnormal_protein_level1.16920112
51MP0003786_premature_aging1.16593860
52MP0002822_catalepsy1.16136276
53MP0002006_tumorigenesis1.16006593
54MP0005075_abnormal_melanosome_morpholog1.13811865
55MP0004142_abnormal_muscle_tone1.12410720
56MP0001919_abnormal_reproductive_system1.11656355
57MP0006276_abnormal_autonomic_nervous1.09356644
58MP0002638_abnormal_pupillary_reflex1.07021068
59MP0002429_abnormal_blood_cell1.06496301
60MP0001485_abnormal_pinna_reflex1.06088497
61MP0004885_abnormal_endolymph1.05470581
62MP0003878_abnormal_ear_physiology1.05214574
63MP0005377_hearing/vestibular/ear_phenot1.05214574
64MP0002837_dystrophic_cardiac_calcinosis1.03634963
65MP0002722_abnormal_immune_system1.00641722
66MP0001764_abnormal_homeostasis1.00565136
67MP0000703_abnormal_thymus_morphology0.99342757
68MP0000689_abnormal_spleen_morphology0.99288399
69MP0001968_abnormal_touch/_nociception0.99283006
70MP0005551_abnormal_eye_electrophysiolog0.98863472
71MP0002102_abnormal_ear_morphology0.98576089
72MP0004742_abnormal_vestibular_system0.96735843
73MP0005389_reproductive_system_phenotype0.96008422
74MP0005166_decreased_susceptibility_to0.95899430
75MP0005646_abnormal_pituitary_gland0.95823457
76MP0009763_increased_sensitivity_to0.95222219
77MP0005464_abnormal_platelet_physiology0.95204688
78MP0001529_abnormal_vocalization0.95052567
79MP0005379_endocrine/exocrine_gland_phen0.94568981
80MP0003195_calcinosis0.93973782
81MP0005410_abnormal_fertilization0.93418660
82MP0003186_abnormal_redox_activity0.91716931
83MP0002909_abnormal_adrenal_gland0.91066900
84MP0008873_increased_physiological_sensi0.88145661
85MP0009764_decreased_sensitivity_to0.87812131
86MP0002139_abnormal_hepatobiliary_system0.85974027
87MP0005670_abnormal_white_adipose0.83163790
88MP0002736_abnormal_nociception_after0.82068736
89MP0003638_abnormal_response/metabolism_0.81231788
90MP0001970_abnormal_pain_threshold0.79858709
91MP0002876_abnormal_thyroid_physiology0.77825853
92MP0005085_abnormal_gallbladder_physiolo0.76522283
93MP0008007_abnormal_cellular_replicative0.76246631
94MP0009046_muscle_twitch0.76037465
95MP0000343_altered_response_to0.75143327
96MP0003075_altered_response_to0.74967827
97MP0006035_abnormal_mitochondrial_morpho0.74028052
98MP0002733_abnormal_thermal_nociception0.72877324
99MP0002095_abnormal_skin_pigmentation0.72621437
100MP0000230_abnormal_systemic_arterial0.71613958

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.36552679
2Mitochondrial inheritance (HP:0001427)4.16552446
3Aplastic anemia (HP:0001915)4.16423162
4Absent rod-and cone-mediated responses on ERG (HP:0007688)4.13054756
5Abnormal mitochondria in muscle tissue (HP:0008316)4.13013236
6Increased hepatocellular lipid droplets (HP:0006565)3.98683985
7Lipid accumulation in hepatocytes (HP:0006561)3.74879591
8Increased intramyocellular lipid droplets (HP:0012240)3.72630661
9Increased CSF lactate (HP:0002490)3.68062146
10Progressive macrocephaly (HP:0004481)3.65628169
11Renal Fanconi syndrome (HP:0001994)3.64332982
123-Methylglutaconic aciduria (HP:0003535)3.60511865
13Acute encephalopathy (HP:0006846)3.60144374
14Recurrent gram-negative bacterial infections (HP:0005420)3.56032597
15IgG deficiency (HP:0004315)3.38503985
16Abnormality of T cell number (HP:0011839)3.38101404
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.34233175
18Hypoproteinemia (HP:0003075)3.30553669
19Cerebral edema (HP:0002181)3.27677476
20Increased muscle lipid content (HP:0009058)3.25550192
21Increased IgM level (HP:0003496)3.24116572
22Absent/shortened dynein arms (HP:0200106)3.24022001
23Dynein arm defect of respiratory motile cilia (HP:0012255)3.24022001
24Exertional dyspnea (HP:0002875)3.14819241
25Autoimmune hemolytic anemia (HP:0001890)3.09338545
26Abnormal rod and cone electroretinograms (HP:0008323)3.08005460
27T lymphocytopenia (HP:0005403)3.05491816
28Abnormal respiratory motile cilium physiology (HP:0012261)3.03567861
29Decreased activity of mitochondrial respiratory chain (HP:0008972)3.01084121
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.01084121
31Elevated erythrocyte sedimentation rate (HP:0003565)2.89167243
32Chronic bronchitis (HP:0004469)2.88407457
33Hepatocellular necrosis (HP:0001404)2.86013777
34Congenital stationary night blindness (HP:0007642)2.85281463
35Leukocytosis (HP:0001974)2.83955879
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.78250106
37Aplasia/hypoplasia of the uterus (HP:0008684)2.69489385
38Constricted visual fields (HP:0001133)2.69031414
39Attenuation of retinal blood vessels (HP:0007843)2.64328194
40Abnormality of macular pigmentation (HP:0008002)2.62533010
41B lymphocytopenia (HP:0010976)2.59035758
42Respiratory difficulties (HP:0002880)2.57662875
43Recurrent abscess formation (HP:0002722)2.55665252
44Decreased electroretinogram (ERG) amplitude (HP:0000654)2.54204641
45Hypoplasia of the uterus (HP:0000013)2.52517992
46Hyperglycinemia (HP:0002154)2.50359065
47Optic disc pallor (HP:0000543)2.48691801
48Abnormality of eosinophils (HP:0001879)2.46763998
49Abnormality of T cells (HP:0002843)2.44708374
50Eosinophilia (HP:0001880)2.41140593
51Chronic sinusitis (HP:0011109)2.35121201
52Abolished electroretinogram (ERG) (HP:0000550)2.34926319
53Abnormality of B cell number (HP:0010975)2.34448373
54Hepatic necrosis (HP:0002605)2.31952972
55Abnormal respiratory epithelium morphology (HP:0012253)2.31692471
56Abnormal respiratory motile cilium morphology (HP:0005938)2.31692471
57Severe combined immunodeficiency (HP:0004430)2.29952371
58Periodontitis (HP:0000704)2.23320814
59Increased serum lactate (HP:0002151)2.22723284
60Abnormality of the prostate (HP:0008775)2.22599948
61Abnormality of renal resorption (HP:0011038)2.20259352
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.19813755
63Lactic acidosis (HP:0003128)2.19290174
64Abnormal ciliary motility (HP:0012262)2.16917535
65Abnormal delayed hypersensitivity skin test (HP:0002963)2.16875848
66Abnormality of urine glucose concentration (HP:0011016)2.15251382
67Glycosuria (HP:0003076)2.15251382
68Lethargy (HP:0001254)2.13392239
69Type I transferrin isoform profile (HP:0003642)2.12564441
70Supernumerary spleens (HP:0009799)2.12302250
71Abnormality of cells of the erythroid lineage (HP:0012130)2.09417161
72Hyperphosphaturia (HP:0003109)2.02101639
73Exercise intolerance (HP:0003546)2.00750754
74Pancytopenia (HP:0001876)1.99825291
75Respiratory failure (HP:0002878)1.94346572
76Dicarboxylic aciduria (HP:0003215)1.94152822
77Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94152822
78Abnormal number of erythroid precursors (HP:0012131)1.93290838
79Thyroiditis (HP:0100646)1.93137405
80Stenosis of the external auditory canal (HP:0000402)1.92067019
81Bronchiectasis (HP:0002110)1.90213568
82Bronchitis (HP:0012387)1.89726506
83Meningitis (HP:0001287)1.89582682
84Chronic diarrhea (HP:0002028)1.89464567
85Rhinitis (HP:0012384)1.87925644
86Autoimmune thrombocytopenia (HP:0001973)1.87491861
87Encephalitis (HP:0002383)1.87111003
88Cerebral palsy (HP:0100021)1.81496305
89IgM deficiency (HP:0002850)1.80271331
90Abnormality of serine family amino acid metabolism (HP:0010894)1.79852616
91Abnormality of glycine metabolism (HP:0010895)1.79852616
92Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79717527
93Bony spicule pigmentary retinopathy (HP:0007737)1.79046875
94Aplasia/Hypoplasia of the spleen (HP:0010451)1.74832699
95Abnormality of cells of the lymphoid lineage (HP:0012140)1.73716381
96Agammaglobulinemia (HP:0004432)1.72907978
97Type 2 muscle fiber atrophy (HP:0003554)1.72270011
98Combined immunodeficiency (HP:0005387)1.72024233
99Stomatitis (HP:0010280)1.70940229
100Asplenia (HP:0001746)1.70624115

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.37211945
2MAP3K123.76565294
3MAP4K23.70694774
4VRK23.62685177
5BCKDK3.30875639
6TLK13.09368901
7TESK22.85692184
8TXK2.73993918
9ZAK2.73378007
10TAOK32.59902901
11VRK12.58763790
12ADRBK22.13649319
13FES2.02525165
14SCYL21.99826326
15MAP4K11.96638529
16CDK191.91296350
17MYLK1.87603072
18TIE11.85458544
19DAPK11.80160172
20BUB11.79667167
21GRK11.70813614
22PRKCH1.68750211
23GRK61.45995785
24TESK11.32217228
25NUAK11.32114574
26GRK71.30193510
27PRKCQ1.20018894
28ILK1.17706517
29TAF11.17087783
30DAPK31.15904618
31EIF2AK31.08392626
32CSK1.07646084
33SYK1.05920090
34KIT1.02932068
35MST41.00780437
36BMPR1B1.00588649
37PBK1.00294131
38BMPR20.99717023
39LIMK10.98244506
40JAK30.97121463
41ITK0.94516728
42FRK0.92494034
43MAPK150.91199438
44LCK0.91099616
45INSRR0.90303585
46MATK0.87964283
47ADRBK10.85787321
48MAP3K110.83573991
49NEK10.79857064
50PKN10.79487086
51TEC0.79063806
52ERBB30.78861031
53BTK0.76908837
54CSF1R0.75990175
55GRK50.73545221
56PINK10.71213061
57LYN0.69051615
58PIK3CG0.68905640
59OXSR10.64872204
60PRKCD0.59664218
61IKBKB0.59111950
62TNK20.57912419
63MAPKAPK50.57212390
64AURKA0.56859663
65RIPK40.56664070
66ZAP700.55124443
67MUSK0.53530402
68OBSCN0.53465479
69WNK40.51872079
70DYRK20.51460800
71RPS6KA50.51346032
72ROCK10.51284841
73TRPM70.49429897
74CSNK1G30.48998858
75PRKCA0.40697118
76IGF1R0.38218968
77PRKACA0.37490287
78TYRO30.37422267
79PIM10.37386727
80CSNK1A1L0.36719047
81CSNK1G20.36596866
82AURKB0.35684024
83NEK20.33909215
84STK38L0.33737580
85WNK30.33447242
86CSNK1G10.32703456
87PIM20.32251560
88WEE10.32188553
89NME20.31638586
90CAMK2A0.30669797
91FLT30.30057242
92LRRK20.30038926
93PRKCB0.28935624
94PAK10.28780517
95CSNK2A10.28684163
96TBK10.28569757
97CSNK2A20.27944646
98PRKCE0.27722632
99ABL20.27679442
100PLK40.27158078

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.62602829
2Oxidative phosphorylation_Homo sapiens_hsa001903.55923521
3Graft-versus-host disease_Homo sapiens_hsa053323.46109979
4Ribosome_Homo sapiens_hsa030103.44191616
5Allograft rejection_Homo sapiens_hsa053303.35539423
6Autoimmune thyroid disease_Homo sapiens_hsa053203.32983181
7Parkinsons disease_Homo sapiens_hsa050123.26242922
8Proteasome_Homo sapiens_hsa030503.21467674
9Asthma_Homo sapiens_hsa053103.14488035
10Type I diabetes mellitus_Homo sapiens_hsa049402.77145028
11Antigen processing and presentation_Homo sapiens_hsa046122.52077785
12RNA polymerase_Homo sapiens_hsa030202.51373897
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.47868554
14Viral myocarditis_Homo sapiens_hsa054162.26224783
15Alzheimers disease_Homo sapiens_hsa050102.01106492
16Huntingtons disease_Homo sapiens_hsa050161.96082464
17Rheumatoid arthritis_Homo sapiens_hsa053231.95300075
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.89196515
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.80561473
20Staphylococcus aureus infection_Homo sapiens_hsa051501.75088248
21Protein export_Homo sapiens_hsa030601.66377557
22Hematopoietic cell lineage_Homo sapiens_hsa046401.54266010
23Systemic lupus erythematosus_Homo sapiens_hsa053221.50561264
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49192012
25Cardiac muscle contraction_Homo sapiens_hsa042601.48050366
26Leishmaniasis_Homo sapiens_hsa051401.34739353
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33686983
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.25310076
29Malaria_Homo sapiens_hsa051441.21609304
30Phototransduction_Homo sapiens_hsa047441.14665940
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11766722
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09949083
33Homologous recombination_Homo sapiens_hsa034401.03352625
34Linoleic acid metabolism_Homo sapiens_hsa005911.00330464
35Sulfur metabolism_Homo sapiens_hsa009200.98663363
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97427670
37Pyrimidine metabolism_Homo sapiens_hsa002400.94704904
38Legionellosis_Homo sapiens_hsa051340.90389250
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88534034
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85089163
41Basal transcription factors_Homo sapiens_hsa030220.84182355
42Chemical carcinogenesis_Homo sapiens_hsa052040.81103984
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79875190
44Arachidonic acid metabolism_Homo sapiens_hsa005900.76898406
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76573808
46Nitrogen metabolism_Homo sapiens_hsa009100.74026385
47T cell receptor signaling pathway_Homo sapiens_hsa046600.73420397
48Purine metabolism_Homo sapiens_hsa002300.71971268
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70710384
50Peroxisome_Homo sapiens_hsa041460.69914311
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69699761
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69553831
53Olfactory transduction_Homo sapiens_hsa047400.66961370
54Retinol metabolism_Homo sapiens_hsa008300.65343094
55Glutathione metabolism_Homo sapiens_hsa004800.64937240
56Measles_Homo sapiens_hsa051620.59761153
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.57436150
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57156743
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57053460
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55623694
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.50702748
62Herpes simplex infection_Homo sapiens_hsa051680.50598698
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50116526
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.49884573
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48899992
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.47429901
67Alcoholism_Homo sapiens_hsa050340.46549279
68Collecting duct acid secretion_Homo sapiens_hsa049660.45543248
69Pertussis_Homo sapiens_hsa051330.43868811
70Spliceosome_Homo sapiens_hsa030400.39237305
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38985498
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.38788743
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38562610
74One carbon pool by folate_Homo sapiens_hsa006700.36473014
75Metabolic pathways_Homo sapiens_hsa011000.36321859
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34445040
77Fat digestion and absorption_Homo sapiens_hsa049750.34276993
78Tuberculosis_Homo sapiens_hsa051520.34255859
79Epstein-Barr virus infection_Homo sapiens_hsa051690.33672526
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33484606
81RNA degradation_Homo sapiens_hsa030180.33001172
82Nicotine addiction_Homo sapiens_hsa050330.32303230
83Butanoate metabolism_Homo sapiens_hsa006500.30991433
84Propanoate metabolism_Homo sapiens_hsa006400.30002935
85Phagosome_Homo sapiens_hsa041450.29708323
86Nucleotide excision repair_Homo sapiens_hsa034200.29074512
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.26688727
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.26453479
89Salmonella infection_Homo sapiens_hsa051320.26020647
90Caffeine metabolism_Homo sapiens_hsa002320.25712641
91Sulfur relay system_Homo sapiens_hsa041220.24814245
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24343835
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22808416
94Base excision repair_Homo sapiens_hsa034100.22341558
95African trypanosomiasis_Homo sapiens_hsa051430.21420501
96Fanconi anemia pathway_Homo sapiens_hsa034600.21395556
97Complement and coagulation cascades_Homo sapiens_hsa046100.20627591
98Taste transduction_Homo sapiens_hsa047420.18536474
99Influenza A_Homo sapiens_hsa051640.16158690
100RNA transport_Homo sapiens_hsa030130.15994119

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