ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	9.68027748
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	9.07683180
3	cytidine deamination (GO:0009972)	7.80698716
4	cytidine metabolic process (GO:0046087)	7.80698716
5	cytidine catabolic process (GO:0006216)	7.80698716
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	6.57390448
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.71627964
8	cellular response to interleukin-15 (GO:0071350)	4.46266345
9	response to pheromone (GO:0019236)	4.19160065
10	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.13385243
11	base-excision repair, AP site formation (GO:0006285)	4.10717594
12	axonemal dynein complex assembly (GO:0070286)	4.02586827
13	positive regulation of prostaglandin secretion (GO:0032308)	3.89191829
14	behavioral response to nicotine (GO:0035095)	3.83730023
15	ribosomal small subunit assembly (GO:0000028)	3.73854868
16	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	3.58379878
17	ATP synthesis coupled proton transport (GO:0015986)	3.55139864
18	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.55139864
19	chaperone mediated protein folding requiring cofactor (GO:0051085)	3.47710047
20	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.47137014
21	response to interleukin-15 (GO:0070672)	3.39416907
22	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.36231506
23	rRNA modification (GO:0000154)	3.30702804
24	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.28986275
25	protein complex biogenesis (GO:0070271)	3.25883840
26	GTP biosynthetic process (GO:0006183)	3.25455653
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.24468862
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.24468862
29	NADH dehydrogenase complex assembly (GO:0010257)	3.24468862
30	pyrimidine nucleoside catabolic process (GO:0046135)	3.19373530
31	chaperone-mediated protein transport (GO:0072321)	3.15874971
32	regulation of prostaglandin secretion (GO:0032306)	3.14581851
33	negative regulation of reactive oxygen species metabolic process (GO:2000378)	3.14132286
34	protein-cofactor linkage (GO:0018065)	3.13898079
35	positive regulation of fatty acid transport (GO:2000193)	3.13131981
36	positive regulation of T cell differentiation in thymus (GO:0033089)	3.09234790
37	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.09221076
38	piRNA metabolic process (GO:0034587)	3.07462671
39	pyrimidine ribonucleoside metabolic process (GO:0046131)	3.04454193
40	estrogen biosynthetic process (GO:0006703)	3.03073029
41	UTP biosynthetic process (GO:0006228)	3.01379284
42	respiratory chain complex IV assembly (GO:0008535)	3.00933439
43	immunoglobulin mediated immune response (GO:0016064)	2.97679377
44	actin nucleation (GO:0045010)	2.96939848
45	water-soluble vitamin biosynthetic process (GO:0042364)	2.96414224
46	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.96205647
47	mitochondrial respiratory chain complex assembly (GO:0033108)	2.91376853
48	respiratory electron transport chain (GO:0022904)	2.90667348
49	mannosylation (GO:0097502)	2.88356065
50	electron transport chain (GO:0022900)	2.87911506
51	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.87906541
52	positive regulation of icosanoid secretion (GO:0032305)	2.87452114
53	preassembly of GPI anchor in ER membrane (GO:0016254)	2.85553175
54	cellular ketone body metabolic process (GO:0046950)	2.85101035
55	UTP metabolic process (GO:0046051)	2.79650633
56	T cell migration (GO:0072678)	2.78557787
57	pyrimidine-containing compound catabolic process (GO:0072529)	2.78068138
58	positive regulation of defense response to virus by host (GO:0002230)	2.77647836
59	rRNA methylation (GO:0031167)	2.77449594
60	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.77110517
61	negative regulation of viral genome replication (GO:0045071)	2.71865964
62	epithelial cilium movement (GO:0003351)	2.70230545
63	regulation of B cell receptor signaling pathway (GO:0050855)	2.69927192
64	deoxyribonucleotide catabolic process (GO:0009264)	2.69462540
65	positive regulation of interleukin-8 secretion (GO:2000484)	2.67146841
66	regulation of T cell mediated cytotoxicity (GO:0001914)	2.64407429
67	GPI anchor biosynthetic process (GO:0006506)	2.64392057
68	deoxyribose phosphate catabolic process (GO:0046386)	2.63663242
69	sperm motility (GO:0030317)	2.62104306
70	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.60875985
71	regulation of T cell receptor signaling pathway (GO:0050856)	2.59055242
72	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.58948048
73	pyrimidine nucleotide catabolic process (GO:0006244)	2.58301350
74	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.58253199
75	positive regulation of T cell apoptotic process (GO:0070234)	2.57396279
76	GPI anchor metabolic process (GO:0006505)	2.56821229
77	positive regulation of calcium-mediated signaling (GO:0050850)	2.55606749
78	indolalkylamine metabolic process (GO:0006586)	2.55221302
79	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.54289328
80	DNA methylation involved in gamete generation (GO:0043046)	2.53391469
81	C4-dicarboxylate transport (GO:0015740)	2.53131758
82	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.52951303
83	negative regulation of B cell proliferation (GO:0030889)	2.52202001
84	indole-containing compound catabolic process (GO:0042436)	2.50799762
85	indolalkylamine catabolic process (GO:0046218)	2.50799762
86	tryptophan catabolic process (GO:0006569)	2.50799762
87	ketone body metabolic process (GO:1902224)	2.50295936
88	neuron fate determination (GO:0048664)	2.50102875
89	cytochrome complex assembly (GO:0017004)	2.49410741
90	cilium or flagellum-dependent cell motility (GO:0001539)	2.48886281
91	negative regulation of telomere maintenance (GO:0032205)	2.48360349
92	protein polyglutamylation (GO:0018095)	2.47928632
93	multicellular organism reproduction (GO:0032504)	2.47666149
94	cilium movement (GO:0003341)	2.45858056
95	iron-sulfur cluster assembly (GO:0016226)	2.43137295
96	metallo-sulfur cluster assembly (GO:0031163)	2.43137295
97	protein peptidyl-prolyl isomerization (GO:0000413)	2.43003268
98	B cell mediated immunity (GO:0019724)	2.42966928
99	negative T cell selection (GO:0043383)	2.39795505
100	platelet dense granule organization (GO:0060155)	2.39570920

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.99145816
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.39042946
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.32360560
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.57002235
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.73257117
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.69583984
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.69150589
8	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.65074061
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.56095200
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.44778777
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.33150051
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.32254165
13	VDR_22108803_ChIP-Seq_LS180_Human	2.30432097
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.20763763
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.20707709
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.14660145
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.13101285
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.08186613
19	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.03400521
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.94179234
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.89577759
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.86386040
23	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.80464293
24	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.71582294
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.69332950
26	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.68848258
27	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.67543558
28	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.61098820
29	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.59851606
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.55327475
31	CIITA_25753668_ChIP-Seq_RAJI_Human	1.52566718
32	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.51527939
33	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.50328883
34	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.50101004
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.48345863
36	AR_20517297_ChIP-Seq_VCAP_Human	1.47149292
37	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.44079783
38	FOXP3_21729870_ChIP-Seq_TREG_Human	1.41918653
39	EWS_26573619_Chip-Seq_HEK293_Human	1.41191023
40	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.40406309
41	SOX2_19829295_ChIP-Seq_ESCs_Human	1.40377384
42	NANOG_19829295_ChIP-Seq_ESCs_Human	1.40377384
43	RUNX_20019798_ChIP-Seq_JUKART_Human	1.39304520
44	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.39033458
45	TAF2_19829295_ChIP-Seq_ESCs_Human	1.38554001
46	ERA_21632823_ChIP-Seq_H3396_Human	1.36964833
47	NANOG_20526341_ChIP-Seq_ESCs_Human	1.36506191
48	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.35647134
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33308307
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33308307
51	ELK1_19687146_ChIP-ChIP_HELA_Human	1.32963744
52	MYB_26560356_Chip-Seq_TH2_Human	1.32582988
53	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.32388410
54	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.31860906
55	GATA3_26560356_Chip-Seq_TH2_Human	1.30950834
56	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.30844416
57	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.28781420
58	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.23664783
59	TP53_22573176_ChIP-Seq_HFKS_Human	1.22775360
60	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.22389082
61	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20186129
62	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.18488189
63	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.18479970
64	BCL6_27268052_Chip-Seq_Bcells_Human	1.15171976
65	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.14106346
66	ER_23166858_ChIP-Seq_MCF-7_Human	1.12833064
67	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.12017042
68	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.11861752
69	ERG_20517297_ChIP-Seq_VCAP_Human	1.11609722
70	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.09946591
71	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09913610
72	BCAT_22108803_ChIP-Seq_LS180_Human	1.08252675
73	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.08093372
74	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.05955810
75	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.05463302
76	MYC_19829295_ChIP-Seq_ESCs_Human	1.04821433
77	FUS_26573619_Chip-Seq_HEK293_Human	1.02023092
78	CTCF_20526341_ChIP-Seq_ESCs_Human	1.00624407
79	P300_27268052_Chip-Seq_Bcells_Human	1.00271506
80	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.98616497
81	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.98241276
82	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.97931962
83	P53_21459846_ChIP-Seq_SAOS-2_Human	0.95220112
84	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.95026881
85	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.94912859
86	NCOR_22424771_ChIP-Seq_293T_Human	0.94904884
87	P300_19829295_ChIP-Seq_ESCs_Human	0.93992954
88	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92751473
89	GATA3_27048872_Chip-Seq_THYMUS_Human	0.91982074
90	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.91889662
91	STAT1_20625510_ChIP-Seq_HELA_Human	0.91205356
92	HOXB7_26014856_ChIP-Seq_BT474_Human	0.89142125
93	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.88133780
94	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.87114337
95	OCT4_20526341_ChIP-Seq_ESCs_Human	0.86392283
96	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.85967986
97	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.85868851
98	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.85834006
99	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.85422161
100	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.85117357

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.47797452
2	MP0002138_abnormal_hepatobiliary_system	3.69166290
3	MP0005645_abnormal_hypothalamus_physiol	3.45614518
4	MP0002638_abnormal_pupillary_reflex	2.98927023
5	MP0006072_abnormal_retinal_apoptosis	2.81673849
6	MP0005377_hearing/vestibular/ear_phenot	2.60371697
7	MP0003878_abnormal_ear_physiology	2.60371697
8	MP0001835_abnormal_antigen_presentation	2.56458142
9	MP0004885_abnormal_endolymph	2.53133434
10	MP0000685_abnormal_immune_system	2.47835502
11	MP0003011_delayed_dark_adaptation	2.36789159
12	MP0005084_abnormal_gallbladder_morpholo	2.25955587
13	MP0005253_abnormal_eye_physiology	2.21556142
14	MP0000372_irregular_coat_pigmentation	2.06031798
15	MP0004145_abnormal_muscle_electrophysio	2.03070411
16	MP0001968_abnormal_touch/_nociception	1.98186311
17	MP0005410_abnormal_fertilization	1.89717993
18	MP0009333_abnormal_splenocyte_physiolog	1.85261525
19	MP0001800_abnormal_humoral_immune	1.83268867
20	MP0001485_abnormal_pinna_reflex	1.72056607
21	MP0009785_altered_susceptibility_to	1.65749530
22	MP0008872_abnormal_physiological_respon	1.62375241
23	MP0002102_abnormal_ear_morphology	1.59881370
24	MP0008877_abnormal_DNA_methylation	1.59126724
25	MP0005551_abnormal_eye_electrophysiolog	1.57260049
26	MP0003763_abnormal_thymus_physiology	1.54998751
27	MP0004742_abnormal_vestibular_system	1.53677482
28	MP0002736_abnormal_nociception_after	1.53645956
29	MP0009379_abnormal_foot_pigmentation	1.53393524
30	MP0005379_endocrine/exocrine_gland_phen	1.53125169
31	MP0008875_abnormal_xenobiotic_pharmacok	1.51277009
32	MP0005387_immune_system_phenotype	1.48293809
33	MP0001790_abnormal_immune_system	1.48293809
34	MP0002723_abnormal_immune_serum	1.46814983
35	MP0003806_abnormal_nucleotide_metabolis	1.46786647
36	MP0005000_abnormal_immune_tolerance	1.40690973
37	MP0009046_muscle_twitch	1.38401094
38	MP0002148_abnormal_hypersensitivity_rea	1.35114416
39	MP0001819_abnormal_immune_cell	1.34647875
40	MP0005083_abnormal_biliary_tract	1.34351664
41	MP0002420_abnormal_adaptive_immunity	1.33442006
42	MP0001986_abnormal_taste_sensitivity	1.32980758
43	MP0003693_abnormal_embryo_hatching	1.32669159
44	MP0001348_abnormal_lacrimal_gland	1.31017253
45	MP0001919_abnormal_reproductive_system	1.29276034
46	MP0000538_abnormal_urinary_bladder	1.27428888
47	MP0002277_abnormal_respiratory_mucosa	1.26503414
48	MP0002452_abnormal_antigen_presenting	1.26175657
49	MP0003866_abnormal_defecation	1.25325465
50	MP0002876_abnormal_thyroid_physiology	1.18647483
51	MP0001905_abnormal_dopamine_level	1.17365974
52	MP0002163_abnormal_gland_morphology	1.16493747
53	MP0003045_fibrosis	1.15221763
54	MP0010386_abnormal_urinary_bladder	1.14338369
55	MP0001727_abnormal_embryo_implantation	1.12508057
56	MP0000026_abnormal_inner_ear	1.10607302
57	MP0003880_abnormal_central_pattern	1.10008249
58	MP0005025_abnormal_response_to	1.09849757
59	MP0001984_abnormal_olfaction	1.09571284
60	MP0001873_stomach_inflammation	1.07296627
61	MP0005085_abnormal_gallbladder_physiolo	1.07052884
62	MP0006292_abnormal_olfactory_placode	1.06583034
63	MP0001486_abnormal_startle_reflex	1.06263480
64	MP0003136_yellow_coat_color	1.03232154
65	MP0002282_abnormal_trachea_morphology	1.01205702
66	MP0002928_abnormal_bile_duct	1.01002032
67	MP0008058_abnormal_DNA_repair	0.98621718
68	MP0002733_abnormal_thermal_nociception	0.98443389
69	MP0002234_abnormal_pharynx_morphology	0.98302510
70	MP0000703_abnormal_thymus_morphology	0.97864939
71	MP0001529_abnormal_vocalization	0.97773541
72	MP0000716_abnormal_immune_system	0.97764491
73	MP0002398_abnormal_bone_marrow	0.97428303
74	MP0004142_abnormal_muscle_tone	0.95815771
75	MP0003646_muscle_fatigue	0.93750604
76	MP0003252_abnormal_bile_duct	0.92643544
77	MP0009745_abnormal_behavioral_response	0.91931406
78	MP0009764_decreased_sensitivity_to	0.91714585
79	MP0006036_abnormal_mitochondrial_physio	0.90414374
80	MP0002272_abnormal_nervous_system	0.90401873
81	MP0005310_abnormal_salivary_gland	0.90387372
82	MP0005365_abnormal_bile_salt	0.86899718
83	MP0005195_abnormal_posterior_eye	0.85930710
84	MP0001929_abnormal_gametogenesis	0.83954603
85	MP0005391_vision/eye_phenotype	0.83503731
86	MP0001970_abnormal_pain_threshold	0.83050305
87	MP0001963_abnormal_hearing_physiology	0.82625561
88	MP0001764_abnormal_homeostasis	0.81064559
89	MP0002095_abnormal_skin_pigmentation	0.78358127
90	MP0002249_abnormal_larynx_morphology	0.78216306
91	MP0005389_reproductive_system_phenotype	0.77719205
92	MP0008789_abnormal_olfactory_epithelium	0.77491664
93	MP0003137_abnormal_impulse_conducting	0.77471368
94	MP0008995_early_reproductive_senescence	0.76642827
95	MP0006035_abnormal_mitochondrial_morpho	0.74975339
96	MP0002254_reproductive_system_inflammat	0.74903185
97	MP0002166_altered_tumor_susceptibility	0.74775369
98	MP0000049_abnormal_middle_ear	0.71042151
99	MP0002429_abnormal_blood_cell	0.69237172
100	MP0006276_abnormal_autonomic_nervous	0.68351447

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent/shortened dynein arms (HP:0200106)	5.86837460
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.86837460
3	Abnormal respiratory motile cilium morphology (HP:0005938)	4.45140810
4	Abnormal respiratory epithelium morphology (HP:0012253)	4.45140810
5	Abnormal ciliary motility (HP:0012262)	4.29385674
6	IgG deficiency (HP:0004315)	3.95010292
7	Abnormal respiratory motile cilium physiology (HP:0012261)	3.65863066
8	Colon cancer (HP:0003003)	3.61625625
9	Elevated erythrocyte sedimentation rate (HP:0003565)	3.27049594
10	Abnormality of midbrain morphology (HP:0002418)	3.15779503
11	Molar tooth sign on MRI (HP:0002419)	3.15779503
12	Mitochondrial inheritance (HP:0001427)	3.15760489
13	Abnormality of the prostate (HP:0008775)	3.10633881
14	Acute necrotizing encephalopathy (HP:0006965)	3.09545894
15	Supernumerary spleens (HP:0009799)	3.07518731
16	Congenital stationary night blindness (HP:0007642)	3.03156792
17	Increased hepatocellular lipid droplets (HP:0006565)	2.93552689
18	Prostate neoplasm (HP:0100787)	2.90618249
19	Pancreatic cysts (HP:0001737)	2.87599131
20	Abnormal mitochondria in muscle tissue (HP:0008316)	2.87366439
21	True hermaphroditism (HP:0010459)	2.80631359
22	Renal Fanconi syndrome (HP:0001994)	2.77192712
23	Acute encephalopathy (HP:0006846)	2.74328789
24	Increased CSF lactate (HP:0002490)	2.66930681
25	Short tibia (HP:0005736)	2.55749059
26	Volvulus (HP:0002580)	2.55529274
27	Lipid accumulation in hepatocytes (HP:0006561)	2.54663337
28	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.49002857
29	Abnormality of T cells (HP:0002843)	2.48904688
30	Abnormality of T cell physiology (HP:0011840)	2.48100441
31	IgM deficiency (HP:0002850)	2.46773548
32	Abnormal drinking behavior (HP:0030082)	2.46724033
33	Polydipsia (HP:0001959)	2.46724033
34	Recurrent sinusitis (HP:0011108)	2.46163359
35	Conical tooth (HP:0000698)	2.44250134
36	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.42532297
37	Progressive macrocephaly (HP:0004481)	2.42067101
38	Bronchiectasis (HP:0002110)	2.41471521
39	Hepatocellular necrosis (HP:0001404)	2.39627973
40	Sclerocornea (HP:0000647)	2.37490003
41	Chronic sinusitis (HP:0011109)	2.35554118
42	Obstructive lung disease (HP:0006536)	2.35008142
43	Chronic obstructive pulmonary disease (HP:0006510)	2.35008142
44	Abnormality of male internal genitalia (HP:0000022)	2.34933299
45	Pancreatic fibrosis (HP:0100732)	2.32479133
46	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.32290664
47	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.31761702
48	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.31761702
49	Severe combined immunodeficiency (HP:0004430)	2.22537785
50	Abnormal albumin level (HP:0012116)	2.21991838
51	Hypoalbuminemia (HP:0003073)	2.21991838
52	Type 2 muscle fiber atrophy (HP:0003554)	2.21713480
53	Rhinitis (HP:0012384)	2.20689171
54	Abnormal rod and cone electroretinograms (HP:0008323)	2.19510559
55	B lymphocytopenia (HP:0010976)	2.19425083
56	Tetany (HP:0001281)	2.19154750
57	Cerebral edema (HP:0002181)	2.16592652
58	Abnormality of the pleura (HP:0002103)	2.15723302
59	Increased intramyocellular lipid droplets (HP:0012240)	2.15334763
60	Hyperglycinemia (HP:0002154)	2.13552309
61	T lymphocytopenia (HP:0005403)	2.08845504
62	Abnormality of B cell number (HP:0010975)	2.08748581
63	Chronic mucocutaneous candidiasis (HP:0002728)	2.08425744
64	Recurrent cutaneous fungal infections (HP:0011370)	2.08425744
65	Agammaglobulinemia (HP:0004432)	2.07904022
66	Meningitis (HP:0001287)	2.06801128
67	Muscle fiber atrophy (HP:0100295)	2.06659537
68	Hepatic necrosis (HP:0002605)	2.04811346
69	Vasculitis (HP:0002633)	2.01875505
70	Abnormality of T cell number (HP:0011839)	2.00570547
71	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.99581304
72	Progressive microcephaly (HP:0000253)	1.99043631
73	Hypoplasia of the thymus (HP:0000778)	1.97712945
74	Aplastic anemia (HP:0001915)	1.97269769
75	Optic disc pallor (HP:0000543)	1.97258150
76	Abolished electroretinogram (ERG) (HP:0000550)	1.96950982
77	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.95741258
78	Nephronophthisis (HP:0000090)	1.93563336
79	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.93453148
80	3-Methylglutaconic aciduria (HP:0003535)	1.91919609
81	Cleft eyelid (HP:0000625)	1.90632646
82	Hypoproteinemia (HP:0003075)	1.89855373
83	Increased serum lactate (HP:0002151)	1.89723540
84	Increased IgM level (HP:0003496)	1.88068996
85	Chronic bronchitis (HP:0004469)	1.87406915
86	Abnormality of urine glucose concentration (HP:0011016)	1.86271886
87	Glycosuria (HP:0003076)	1.86271886
88	Polyuria (HP:0000103)	1.83493873
89	Hemiparesis (HP:0001269)	1.81787936
90	Thyroiditis (HP:0100646)	1.80379957
91	Pancytopenia (HP:0001876)	1.79844846
92	Panhypogammaglobulinemia (HP:0003139)	1.79068160
93	Pigmentary retinal degeneration (HP:0001146)	1.78932066
94	Dry hair (HP:0011359)	1.77957550
95	Stomach cancer (HP:0012126)	1.77353385
96	Bronchitis (HP:0012387)	1.76943696
97	Bile duct proliferation (HP:0001408)	1.75684824
98	Abnormal biliary tract physiology (HP:0012439)	1.75684824
99	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.71098241
100	Lactic acidosis (HP:0003128)	1.70800458

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	4.86001951
2	TLK1	3.61689181
3	VRK2	3.43741004
4	TXK	3.27098796
5	VRK1	3.24592056
6	ZAK	3.24577777
7	BUB1	2.56758109
8	TAF1	2.55147705
9	MAP3K12	2.46255587
10	NUAK1	2.44241420
11	KDR	2.31347815
12	MAPK15	2.22949131
13	ADRBK2	2.00604807
14	MAP4K2	1.97667889
15	IKBKB	1.76651618
16	TESK2	1.69060906
17	ARAF	1.63359053
18	DYRK2	1.59119882
19	MAPKAPK5	1.56467737
20	MST4	1.53934614
21	MAP3K13	1.51746698
22	MAP3K9	1.50158397
23	INSRR	1.35651334
24	GRK6	1.31411309
25	FRK	1.30961805
26	ITK	1.30554067
27	PINK1	1.29613006
28	MAP4K1	1.29467016
29	TAOK3	1.19083615
30	GRK1	1.19065694
31	DAPK3	1.17574137
32	PNCK	1.17467871
33	BMPR1B	1.13050179
34	RPS6KA5	1.12703400
35	CSNK1G3	1.11147266
36	PKN1	1.10061068
37	WEE1	1.02566816
38	CSNK1G2	0.96259810
39	SYK	0.96104638
40	OXSR1	0.95096586
41	CSNK1A1L	0.94018825
42	TESK1	0.90784884
43	CCNB1	0.89430523
44	PRKCQ	0.89151929
45	TEC	0.88888398
46	BTK	0.86565140
47	PLK4	0.83076294
48	STK39	0.82655355
49	MAPKAPK3	0.81399632
50	GRK5	0.81321175
51	DAPK1	0.81168178
52	CSNK1G1	0.81155235
53	EPHA3	0.75542324
54	WNK4	0.75061156
55	BMPR2	0.73625762
56	LMTK2	0.73233911
57	CSF1R	0.71768079
58	PLK2	0.70029560
59	ROCK1	0.69652250
60	MAPK13	0.69239253
61	LYN	0.67943756
62	MYLK	0.66724067
63	CASK	0.65559607
64	TRIM28	0.63857076
65	AURKA	0.62917118
66	MAP3K11	0.62079480
67	FES	0.61681613
68	TSSK6	0.61555094
69	MAP2K2	0.57802024
70	MAP2K6	0.53460495
71	SMG1	0.53350700
72	PRKG2	0.53085007
73	WNK3	0.53027937
74	LIMK1	0.51404315
75	LCK	0.50612259
76	PLK3	0.48783546
77	SCYL2	0.47659505
78	TIE1	0.45760635
79	IKBKE	0.42535315
80	NME1	0.39596790
81	PTK2B	0.38381069
82	EPHA4	0.38140902
83	AURKB	0.37845023
84	PHKG2	0.35814681
85	PHKG1	0.35814681
86	NTRK3	0.35257367
87	ADRBK1	0.34898904
88	PRKACA	0.33998165
89	BRSK2	0.32353239
90	JAK3	0.31873182
91	EIF2AK3	0.31796057
92	CHEK2	0.31422082
93	PRKCG	0.30867689
94	PRKCE	0.30461993
95	CDC7	0.30033530
96	PRKCD	0.28525217
97	PIK3CG	0.26597291
98	CHUK	0.26404673
99	MAPKAPK2	0.26067628
100	PIM2	0.25860933

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Allograft rejection_Homo sapiens_hsa05330	3.84461990
2	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.79431235
3	Graft-versus-host disease_Homo sapiens_hsa05332	3.57352253
4	Asthma_Homo sapiens_hsa05310	3.40520938
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.29475519
6	Primary immunodeficiency_Homo sapiens_hsa05340	3.26709719
7	Systemic lupus erythematosus_Homo sapiens_hsa05322	3.17766828
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.83578460
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.78727123
10	Antigen processing and presentation_Homo sapiens_hsa04612	2.45101079
11	Parkinsons disease_Homo sapiens_hsa05012	2.36825807
12	Ribosome_Homo sapiens_hsa03010	2.28535477
13	Proteasome_Homo sapiens_hsa03050	2.22561344
14	RNA polymerase_Homo sapiens_hsa03020	2.01690735
15	Viral myocarditis_Homo sapiens_hsa05416	1.92566783
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.85902068
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.80986662
18	Rheumatoid arthritis_Homo sapiens_hsa05323	1.67196303
19	Alcoholism_Homo sapiens_hsa05034	1.59555213
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.56713024
21	Huntingtons disease_Homo sapiens_hsa05016	1.55789947
22	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.51911582
23	Alzheimers disease_Homo sapiens_hsa05010	1.45953869
24	Protein export_Homo sapiens_hsa03060	1.44918241
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.38936728
26	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.32433397
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.31961353
28	Phototransduction_Homo sapiens_hsa04744	1.28001501
29	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.13869766
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.12693196
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03207547
32	Homologous recombination_Homo sapiens_hsa03440	1.01532716
33	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.01469104
34	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.01387442
35	Linoleic acid metabolism_Homo sapiens_hsa00591	0.97507380
36	Nicotine addiction_Homo sapiens_hsa05033	0.96036177
37	Sulfur relay system_Homo sapiens_hsa04122	0.93181019
38	Tryptophan metabolism_Homo sapiens_hsa00380	0.92001879
39	Nitrogen metabolism_Homo sapiens_hsa00910	0.91865745
40	Butanoate metabolism_Homo sapiens_hsa00650	0.91128585
41	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.90529876
42	Propanoate metabolism_Homo sapiens_hsa00640	0.86681272
43	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.86640873
44	Fanconi anemia pathway_Homo sapiens_hsa03460	0.85373711
45	Peroxisome_Homo sapiens_hsa04146	0.84724931
46	Basal transcription factors_Homo sapiens_hsa03022	0.82907765
47	Olfactory transduction_Homo sapiens_hsa04740	0.81929767
48	Base excision repair_Homo sapiens_hsa03410	0.80207855
49	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.79996485
50	Retinol metabolism_Homo sapiens_hsa00830	0.79809722
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.79022160
52	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.74835312
53	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.72443575
54	Pyrimidine metabolism_Homo sapiens_hsa00240	0.71481925
55	Leishmaniasis_Homo sapiens_hsa05140	0.71447346
56	RNA degradation_Homo sapiens_hsa03018	0.70614577
57	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.68786303
58	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.65739962
59	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.64722849
60	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.61399198
61	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.60177039
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58172503
63	Purine metabolism_Homo sapiens_hsa00230	0.57113978
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.56626630
65	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.53625226
66	Herpes simplex infection_Homo sapiens_hsa05168	0.53399698
67	Morphine addiction_Homo sapiens_hsa05032	0.53182615
68	Steroid biosynthesis_Homo sapiens_hsa00100	0.48653625
69	Spliceosome_Homo sapiens_hsa03040	0.48065267
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.39935224
71	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.39699612
72	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.38840396
73	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38367519
74	Sulfur metabolism_Homo sapiens_hsa00920	0.37220506
75	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.37166294
76	Metabolic pathways_Homo sapiens_hsa01100	0.36695098
77	Nucleotide excision repair_Homo sapiens_hsa03420	0.36391591
78	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.34713052
79	Ether lipid metabolism_Homo sapiens_hsa00565	0.34020843
80	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.31515922
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.29147424
82	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.28746769
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.28573810
84	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.28247352
85	Regulation of autophagy_Homo sapiens_hsa04140	0.28141904
86	Folate biosynthesis_Homo sapiens_hsa00790	0.27940514
87	Salivary secretion_Homo sapiens_hsa04970	0.27828197
88	Selenocompound metabolism_Homo sapiens_hsa00450	0.26201032
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.25845946
90	Caffeine metabolism_Homo sapiens_hsa00232	0.25735008
91	One carbon pool by folate_Homo sapiens_hsa00670	0.24485263
92	Taste transduction_Homo sapiens_hsa04742	0.24350629
93	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.22214042
94	Measles_Homo sapiens_hsa05162	0.21143536
95	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.18925927
96	Fat digestion and absorption_Homo sapiens_hsa04975	0.17625634
97	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.17322381
98	Toxoplasmosis_Homo sapiens_hsa05145	0.16546939
99	Collecting duct acid secretion_Homo sapiens_hsa04966	0.15193155
100	Renin-angiotensin system_Homo sapiens_hsa04614	0.15140693

RPS26P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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